Mubarak Oloduowo Ameen
@unilorin.edu.ng
Reader, Chemistry, Physical Sciences
University of Ilorin
Prof. AMEEN Oloduowo Mubarak (FCSN) had his B. Sc. from Bayero University Kano (BUK, 1997), M. Sc. and PhD from University of Ilorin in 2004 and 2015 respectively. He participated in the National University Commission of Nigeria’s Virtual Institute for Higher Education Pedagogy (NUC - VIHEP) from December, 2003 to May, 2004 where he obtained certificates on the various programmes mounted by the institute during this period. He was awarded a Fulbright JSD scholarship tenable at the University of South Florida, USA, between 2011 and 2012.
He joined the service of the Department of Chemistry, University of Ilorin in 1999 as a Graduate Assistant. He is currently a Reader in the Organic Unit of the Department where he Lectures and supervises both graduate and undergraduate research projects. His research interest is in the Medicinal, Natural Products and Synthetic Chemistry.
He has spread publications in home based, national and international journals.
EDUCATION
Doctor of Philosophy ( in Chemistry, University of Ilorin, 2015; Master of Chemistry (M.Sc.) in Chemistry, University of Ilorin, Ilorin, 2004; B.Sc. (Hons.) Chemistry, Bayero University Kano, 1997
RESEARCH INTERESTS
Isolation, characterization and evaluation of Therapeutic potentials of secondary metabolite from Nigerian Flora; Evaluation of nutritional quality of lesser known oil seeds.
Scopus Publications
Scholar Citations
Scholar h-index
Scholar i10-index
Scopus Publications
Adelaja Akinlolu, Adeoye Oyewopo, Risikat Kadir, Mubarak Ameen, Victor Owoniyi, Fauzeeyah Adam, and Shukrat Okeleye
Loki & Dimas
Arsenic-induced carcinogenesis can result in cancers of the liver in exposed organisms. This study evaluated anticancer potentials of MLF1 and AMF1 extracted from Morinda lucida and Annona muicata leaves respectively in Sodium arsenite (SA)-induced toxicity in rats. Sixty adult female rats were randomly divided into 12 groups (n = 5). Group 1 was control. Group 2 received 5-weeks administrations of 10 mg/kg bodyweight of SA. Groups 3-6 received SA-dose for 2 weeks followed by 3-weeks posttreatments with MLF1-doses and AMF1-doses respectively. Groups 7-10 received only 5-weeks administrations of MLF1-doses and AMF1- doses respectively. Groups 11 and 12 received 5-weeks co-administrations of SA-dose with highdoses of MLF1 and AMF1 respectively. Drugs/ extracts were administered orally. Liver histopathology (Heamatoxylin and Eosin) and ELISA concentrations of sera Melatonin and TNF-alpha were evaluated. Malondialdehyde (thiobarbituricacid assay) and p53 (ELISA) levels were evaluated in liver homogenates. Data were statistically analysed. Results showed normal liver histology in Groups 1-12. Post-treatments of SA-induced toxicity with MLF1 and AMF1 resulted in significant (P≤0.05) and non-significant decreased levels (P≥0.05) of Malondialdehyde, TNF-alpha and p53, but significant (P≤0.05) and non-significant increased Melatonin levels (P≥0.05) in Groups 3-12 compared with Group 2. MLF1 and AMF1 possess anticancer, antioxidant, pro-Melatonin, anti-inflammatory and hepato-protective potentials.
Adelaja Akinlolu, Mubarak Ameen, Gabriel Ebito, Nnaemeka Asogwa, Raheem Akindele, Bamidele Fagbounka, Temitope Akintunde, Fatimah Odunola, Simisola Osibowale, and Muhideen Adepeju
Loki & Dimas
Cadmium is a neurotoxin, carcinogen and a suspected agent in aetiology of Parkinson’s disease and Alzheimer’s disease (AD). Furthermore, upregulations of Caspase-3 and p53 were reported in brains of AD patients. This study evaluated the neuroprotective potentials of MO11 (isolated from Moringa oleifera leaves) and MS06 (isolated from Musa sapientum suckers) in Cadmium Chloride (CdCl)-induced neurotoxicity in the cerebrum of rats. Twenty-eight adult male wistar rats (average weight of 155 g) were randomly divided into 7 groups (n = 4). Group 1 received physiological saline. Groups 2-4 and 7 received single 1.5 mg/Kg bodyweight of CdCl (i.p.) (Day 1). Groups 3-4 and 7 were post-treated with 15 mg/Kg bodyweight of MO11, 15 mg/Kg bodyweight of MO11 + 7 mg/Kg bodyweight of MSF1 and 3.35 mg/Kg bodyweight of Doxorubicin respectively (Days 1-17). Groups 5-6 received only MO11 and Vegetable Oil (vehicle) respectively (Days 1-17). Cerebral histopathology (Cresyl Fast Violet method) was evaluated in rats. ELISA evaluations of biomarkers of pro-inflammation (IL-1β, IL-6, IL-8 and NF-kB), anti-inflammation (IL-4 and IL- 10), apoptosis (Caspase-3 and p53), proliferation (Ki67) and angiogenesis (sVEGFR) in cerebral homogenates of rats were also conducted. Histopathological evaluations showed a high number of chromatolytic cells in Group 2, compared with Groups 1 and 3-7. Post-treatments of CdCl-induced neurotoxicity with MO11 and MS06 resulted in decreased levels of IL-1β, IL-6, IL-8, NF-kB, Caspase-3, Ki67, p53 and sVEGFR, but increased levels of IL-4 and IL-10 in Groups 3-4, compared with Group 2. Therefore, MO11 and MS06 possess neuroprotective, neuroregenerative, anti-AD, anti-inflammatory and anticancer potentials. Key words: Cadmium – Neurotoxicity – Alzheimer’s disease – Moringa oleifera – Musa sapientum – Neuroprotection – Neuroregeneration
Adelaja A. Akinlolu, Temitope Omohimoria, Adeoye Oyewopo, Risikat E. Kadir, Mubarak O. Ameen, Olivia Ahialaka, and Simisola Ogunfowora
Acta Pharmaceutica Sciencia
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David A. Animasaun, Mubarak O. Ameen, and Moshood A. Belewu
Springer US
Adelaja Akinlolu, Mubarak Ameen, Tobilola Quadri, Kayode Odubela, Gabriel Omotoso, Rahmat Yahya, Sikiru Biliaminu, Muinat Adeyanju, Gabriel Ebito, and Jubril Otulana
African Journals Online (AJOL)
This study evaluated the neuroprotective effects of MOF6 (isolated from Moringa oleifera leaves) and Trimyristin (isolated from Myristica fragrans seeds) on Acetylcholinesterase concentrations in cerebral cortices of rats with Sodium arsenite-induced neurotoxicity. Sixty-five adult male rats (150 g-250 g) were randomly divided into thirteen groups comprising of five rats per group. Groups 1 and 3 received physiological saline and 1 ml/200 g bodyweight of Olive oil respectively for 9 weeks. Group 2 received 20 mg/kg bodyweight of Sodium arsenite (SA) for 6 weeks and left untreated for another 3 weeks. Groups 4-5 received 20 mg/kg bodyweight of SA for 3 weeks followed by treatments with 5.0 and 7.5 mg/kg bodyweight of MOF6 respectively for 6 weeks. Groups 6-7 received 20 mg/kg bodyweight of SA for 3 weeks followed by treatments with 15 and 30 mg/kg bodyweight of Trimyristin respectively for 6 weeks. Groups 8-11 received 5.0 and 7.5 mg/kg bodyweight of MOF6; 15 and 30 mg/kg bodyweight of Trimyristin respectively for 9 weeks. Groups 12-13 received 7.5 mg/kg bodyweight of MOF6 and 30 mg/kg bodyweight of Trimyristin respectively for 6 weeks followed by co-administration of each extract dose with 20 mg/kg bodyweight of SA for another 3 weeks. Histological examination of cerebral cortices and biochemical analyses of Acetylcholinesterase concentrations were carried out in all rats. Computed data were analyzed using Microsoft Excel 2016 with statistical significance at p≤0.05. Histo-pathological evaluations revealed normal histo-architecture of cerebral cortices of all rats. Results showed statistically significant (p≤0.05) increases in Acetylcholinesterase concentrations in rats of Groups 1-10 and 12 compared with Group 2 (2.78±1.76 𝜇mole/min/g). 7.5 mg/kg bodyweight of MOF6 showed the best therapeutic and neuro-regenerative potential against SA-induced neurotoxicity.Conclusions: Our findings implied that MOF6 and Trimyristin reversed downregulation of Acetylcholinesterase concentrations in SA-induced neurotoxicity in rats; and possess neuro-protective and neuro-regenerative potentials.
Alafara Abdullahi Baba, Joshua S. Ayodele, Oloduowo M. Ameen, Abdulrasaq Jimoh, Folahan A. Adekola, Abdul G. F. Alabi, Marili F. Zubair, Kuranga I. Ayinla, Abdullah S. Ibrahim, Mustapha A. Raji,et al.
Springer International Publishing
Alafara A. Baba, Joshua S. Ayodele, Oloduowo M. Ameen, Abdulrasaq Jimoh, Uduakobong Johnson, Bilikisu A. Jimoh, and Amudat Lawal
Informa UK Limited
ABSTRACT The characterisation of spent transformer oil to determine its fitness for re-refining as well as the recovery of metals by hydrometallurgical treatment in chloride medium has been investigated. The leaching experiments on the spent material showed that its dissolution increases with leachant concentration performed at 75°C. Leaching studies showed that at optimal conditions, the dissolution reached 93% by 1.0 mol L−1 HCl solution within 120 min at 75°C. The solvent extraction of copper by bis(2,2,4-trimethylpentyl) phosphinic acid (CYANEX®272) in kerosene from a pregnant solution of aqueous spent deposited sludge of transformer oil containing 1243.4 mg L−1 Cu++, 389.2 mg L−1 Fe++/+++, 110.7 mg L−1 Ca++ and 235 mg L−1 Al+++ was studied. The results for the solvent extraction give an extraction efficiency of 91.77% total copper acquired via 0.2 mol L−1 CYANEX®272 in kerosene at 27 ± 2°C within 25 min at pH 4.0. A 0.1 mol L−1 HCl solution was found to be sufficient for the stripping of about 94.77% copper from the loaded organic phase. The Fourier transform–infrared spectroscopic analysis of the loaded organic phase supports the stripping experiment as there was no Cu metal ion present in the separated organic phase.
A. C. Tella, J. A. Obaleye, U. B. Eke, A. Y. Isaac, and O. M. Ameen
Springer Science and Business Media LLC
A. Akinlolu, K. Ghazali, O. Ameen, and A. Odewabi
The Brazilian Society of Anatomy (SBA)
Abstract Introduction: Spondias mombin has been reported to possess medicinal properties. Material and Methods: This study evaluated the anti-ulcer properties of Spondias mombin. Rats of Group I received physiological saline only while 40mg/kg/bodyweight of Indomethacin (an ulcerogen) was administered to rats of Groups II - VI. Four hours after administrations of the ulcerogen; rats of Groups III - VI were treated daily with oral administrations of 250, 500 and 1000mg/kg/bodyweight of Spondias mombin bark extract and 40mg/kg/bodyweight of Omeprazole respectively for four days. Rats were euthanized on Days 1 (Group II) and 5 (Groups I and III - VI); stomach and liver samples were removed for evaluations of gastric acidity, histo-pathological and lipid profile status. Results: AAnalyses of gastric acidity and lipid profile status in the stomach and liver samples of rats of Group II showed statistically significant higher levels (P≤0.05) of gastric acidity, total cholesterol, low density lipoprotein-cholesterol and triglycerides but lower high density lipoprotein-cholesterol levels (P≤0.05) when compared to rats of Groups I, and III - VI. Histo-pathological evaluations showed dose-dependent restorations of stomach and liver histology to pre-ulceration states in rats of Groups III - VI. Conclusions: This study concluded that Spondias mombin administrations promoted histo-pathological restorations of the stomach and liver; and lipid profile status of male wistar rats in Indomethacin - induced gastric ulceration.
Abdulazeez Adelaja Akinlolu, Olaide Kamal Ghazali, Oloduowo Mubarak Ameen, Seunayo Comfort Oyebanji, Gabriel Olaiya Omotoso, and Bernard Ufuoma Enaibe
SciELO Agencia Nacional de Investigacion y Desarrollo (ANID)
Se puso a prueba la hipotesis que Moringa oleifera altera la morfologia y funcion del rinon en ratas. Fueron utilizadas 24 ratas Wistar macho adultas. El grupo control recibio suero fisiologico mientras que los Grupos II a IV recibieron 250, 500 y 750 mg/kg peso corporal del extracto metanolico de Moringa oleifera respectivamente, durante 21 dias. No se observaron anomalias en el comportamiento en ratas de los Grupos I - IV. En las ratas del grupo de control se registro un aumento de peso corporal estadisticamente significativo, mientras que las ratas de los grupos II - IV experimentaron una disminucion no significativa de peso corporal durante el procedimiento experimental (P0,05). No se observaron diferencias estadisticamente significativas (P0,05) en el analisis de los pesos relativos en rinones de las ratas de los grupos I - IV. Los examenes histologicos mostraron citoarquitectura normal de los rinones de las ratas del grupo I, mientras que en ratas de los grupos II IV los espacios capsulares de los rinones aparecian mas amplios que los del Grupo I. Los analisis estadisticos mostraron niveles superiores significativos ( P 0,05 ) de la alanina y aspartato aminotransferasa, y de urea en suero en ratas de los Grupos II - IV no dependiente de la dosis, en comparacion con las ratas del Grupo I. Estos resultados coinciden con la hipotesis planteada.
O.F. Okeola, E.O. Odebunmi, and O.M. Ameen
African Journals Online (AJOL)
Activated carbons were prepared from fruit pericarp and seed coat of Jatropha curcas using KOH and NaCl as activating agents leading to the production of four samples of activated carbons JPS, JPP, JCS and JCP. The adsorption capacity based on adsorption of methylene blue was determined for each sample. A further study of adsorptive properties of the most efficient activated carbon (JPS) was made by contacting it with standard solutions of methylene blue, acetic acid and potassium permanganate. The effects of mass of active carbon used, initial concentration of the solute and the pH of the solution on adsorption performance were investigated. Ash content and percentage fixed carbon were determined for two of the activated carbons (JPS and JCS) with the highest adsorptive capacity. Equilibrium study on adsorption was carried out and the adsorption data were analyzed using the Langmuir isotherm. The results obtained indicate that activated carbons from the fruit pericarp and the seed coat of J. curcas can be used as high performance adsorbents with the fruit pericarp activated carbon showing the higher adsorption capacity. The adsorption data fitted well to the Langmuir model and adsorptive area of 824-910 m 2 /g was obtained for the activated carbon.
Usman, A L, Ameen, M O, A Lawal, Awolola, and V G
Academic Journals
Jatropha curcas seeds were processed and defatted to obtain the seed cake. 60 g of them were separately moistened in 0.1 – 0.5 M NaOH and Ca(OH)2 solutions and autoclaved. Each of the autoclaved samples was separately divided into three portions. A portion was washed with ethanol, another with water and the third was left unwashed. Prolamin, albumin, globulin and glutelin fractions were extracted from the treated and untreated seed cakes and subsequently quantified. Untreated seed cake sample express 0.11 g/Kg prolamin, 4.06 g/Kg albumin, 4.23 g/Kg globulin and 10.91 g/Kg glutelin of seed proteins. In Ca(OH)2 treated cake, albumin and globulin had their maximum yield in ethanol washed cake samples. The quantities obtained were 3.95 and 5.11 g/Kg of the seed protein, respectively. Prolamin and glutelin had their maximum yield in unwashed and water washed cake samples. The yields were 4.84 and 9.27 g/Kg of the seed protein, respectively. In NaOH treated seed cake, the four fractions had their maximum yield in water washed cake. The quantities were 3.37, and 3.64 g/Kg of seed protein for prolamin and albumin. The quantities of globulin and glutelin were 4.90 and 9.26 g/Kg of seed proteins. Quantity of prolamin increased in all the treated cake while the quantities of albumin, globulin and glutelin were reduced by the treatments.