enass najem oubaid
@uobabylon.edu.iq
college of pharmacy/university of babylon
lecturer
RESEARCH INTERESTS
pharmacology, pharmaceutical
Scopus Publications
Scopus Publications
Fatima Adnan Alzubaidi, , Enass Najem Oubaid, Zahraa I. J. Shubber, Hussam Wahab Al-Humadi, Rafal J. Al-Saigh, , , , and
PHARMAKON-Press
Reinfection with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that causes coronavirus disease 2019 (COVID-19) has been documented all over the world. Currently, limited evidence exists concerning the protec¬tion afforded by the COVID-19 vaccination against reinfection with SARS-CoV-2. This case-control study was per¬formed in order to assess the association between COVID-19 vaccination and SARS-CoV-2 reinfection in the Babil Province; the study used an electronic questionnaire. The infected patients were 115 (aged ≥18 years) and were confirmed by a positive PCR and/or a CT scan, they were either fully vaccinated or not with a second dose of a (Pfizer, AstraZeneca, or Sinopharm) vaccine before the reinfection date, and they were compared with 300 control partici¬pants. The study’s findings revealed that the unvaccinated individuals had 4.5 times the odds of reinfection compared to those who were fully vaccinated, without preference for the manufacturer of the vaccine. The conclusion suggests that getting fully vaccinated against COVID-19 can significantly reduce the likelihood of reinfection, can enhance overall protection, and can minimize the risk of future infections.
E. Oubaid, Ahmed R. Abu-raghif and I. Al-Sudani
Background: Uncaria tomentosa is a traditional medicinal herb with antiviral, antioxidant, immunostimulating, anti-inflammatory, and anticancer effects. Objective: The present study was conducted to evaluate the antioxidant capacity in vitro and in vivo and the phytochemical analysis of Uncaria tomentosa. Materials and Methods: The plant extract was screened for phytochemical compounds and antioxidant capacity in vitro using the 1,1-diphenyl-2-picrylhydrazyl (DPPH) method and in vivo using acetic acid-induced colitis. Colitis was induced in rats by transrectal administration (5 mL/kg) of 4% (v/v) acetic acid. Forty adult albino rats were divided into four groups: control group, acetic acid group, acetic acid + sulfasalazine (100 mg/kg/day) group, and acetic acid + Uncaria tomentosa extract (250 mg/kg/day) group. After inducing colitis, sulfasalazine and Uncaria tomentosa extract were given orally for 10 days. Data were statistically analyzed, and P < 0.05 was considered statistically significant throughout the study. Results: Preliminary phytochemical study showed that Uncaria tomentosa extract contains flavonoids, phenols alkaloids, saponin, and terpenoids. In the DPPH assay, the extract exhibited considerable antioxidant capacity in a dose-dependent manner. Also, Uncaria tomentosa extract dramatically decreased oxidative stress parameters, such as myeloperoxidase enzyme activity and malondialdehyde in colonic tissue. Moreover, Uncaria tomentosa treatment attenuated macroscopic colonic scores and histopathological changes induced by acetic acid. Conclusion: The findings of this study show that Uncaria tomentosa extract could be a source of natural antioxidants and may have a therapeutic effect on ulcerative colitis.
Enass Najem Oubaid, Ahmed Abu-Raghif, and Israa Mahdi Al-Sudani
Pensoft Publishers
Objectives: This study was carried out to explore the possible anti-inflammatory effect of ibudilast on acetic acid-induced colitis in rats. Methods: Fifty adult Wistar rats were separated into 5 groups, including the control group, acetic acid group, acetic acid + vehicle, acetic acid + sulfasalazine (100 mg/kg/day)group, and acetic acid + ibudilast (30 mg/kg/day) group. Colitis was induced in rats by the inter-rectal installation of 2 ml of 4% (v/v) acetic acid. Sulfasalazine and ibudilast were administered orally for ten days after 2 hours of induction. Results: The treatment with ibudilast significantly reduced disease activity index (DAI), macroscopic colonic scores (MAC), and histopathological changes induced by acetic acid. Also, ibudilast markedly decreased the expression of proinflammatory markers (TNF-α and IL-1β) in colonic tissue. Moreover, ibudilast inhibited myeloperoxidase (MPO) enzyme activity that was increased by acetic acid. Conclusion: Therefore, ibudilast may have a therapeutic effect in the management of ulcerative colitis.
Enass Oubaid, Zainab Chabuck, Rafal Al-Saigh, Nada Hindi, and Samah Kadhum
Science Alert
Fakhir M Alzubaidy, Fatima Adnan Alzubaidi2, Enass Najem Oubaid, and Jasem Hanoon Hashim
Dr. Yashwant Research Labs Pvt. Ltd.
Prednisolone and prednisone are synthetic corticosteroids used to treat different diseases. They are well known to be used for treating many conditions like asthma, autoimmune diseases, many skin conditions, and may help to prevent or at least to suppress inflammations and immune responses. It was proved previously the correlation between prednisolone and the function of liver in patients having liver problems. In patients with alcoholic hepatitis, for example, prednisolone was accompanied with a short-term reduction in the rates of mortality, but this effect was not clear after 2 years. This research was performed to study the possible effects of prednisolone on the histology and the enzyme histochemistry of the liver and kidney in healthy rabbits. Twelve females adult rabbits (Six animals considered as treated group and other six animals as control group) were used in this experiment. After two weeks of adaptation time, treatment by the drug began. Animals treated by prednisolone oral dose 20 mg daily by gavage. Animals sacrificed under anesthesia, then ordinary histological sections (stained with hematoxylin-eosin) and frozen sections (by freezing microtome for Alp activity) of liver and kidney were prepared. The histological results and the ALP activity in both liver and kidney were found to be normal in treated group in compare with the control group. Prednisolone has many various effects on the physiology, psychology, immunology, even the molecular and genetics, varied from beneficial effects to undesired side effects. In the field of hepatology, prednisolone treatment was found to ameliorate many symptoms and enhance many biochemical and histologic abnormal changes in many types of liver diseases like autoimmune hepatitis, liver cirrhosis, septic shock patients, and cases of liver transplantation. In conclusion; according to the results of this research there no any effects of prednisolone on histology of liver and kidney and the ALP activity in these organs.
Fatima Adnan Alzubaidi, Radhwan M. Hussein, Zainab Sajid Mohammed, and Enass Najem Oubaid
Dr. Yashwant Research Labs Pvt. Ltd.
Introduction: Gentamicin is a member of antibiotic group (aminoglycosides), it's very effective in the management of many gram negative bacterial infections but its nephrotoxic effect is considered the major limiting factor. The protective role of Atorvastatin against this adverse effect in male rats was investigated in this study. Materials and methods: thirty adult Wistar male rats were included in the study, they were divided into 3 groups randomly with ten rats in each one, rats in group (1) were given normal standard diet and considered as control. Rats in group (2) were given gentamicin in a dose of 100 mg per kg per day, intraperitoneally for four weeks, while rats in group (3) were given gentamicin in a dose of 100 mg per kg per day, intraperitoneally together with atorvastatin 10 mg per kg per day orally for four weeks. Results: treatment with Gentamicin elevated the level of serum urea, cystatin C, creatinine, total oxidant status and tissue malondialdehyde (MDA) significantly while decreased total antioxidant status significantly. Treatment with Atorvastatin decreased the level of serum urea, creatinine, total oxidant status and tissue MDA significantly while increased total antioxidant status significantly. Renal damage in gentamicin treated rats was determined markedly with histopathological studies in the glomeruli and renal tubules. Conclusion: coadministration of statins with gentamicincan can reduce the nephrotoxicity induced by gentamicin treatment.