Sahabudeen Sheik Mohideen

Scopus Publications

Inhalation of 1-bromopropane alters hippocampal expression of pathways related to immune system/inflammation and insulin signaling in experimental rats
Fen Huang, Sahoko Ichihara, Ying Cheng, Wataru Fujibuchi, Emiko Kitagawa, Satomi Mizukami, Hitoshi Iwahashi, Sahabudeen Sheik Mohideen, Junzoh Kitoh, Seiichiroh Ohsako, Yousra Reda, Cai Zong, Gaku Ichihara
Scientific Reports, 2026
1-Bromopropane, an alternative to ozone-depleting solvents, exhibits neurotoxicity in humans and rats. The aim of the present study was to identify the genes or signaling pathways involved in the neurotoxicity and hepatotoxicity of 1-bomopropane in two inbred strains of rats. F344 rats and WNA/NUM rats were exposed to 1-bromopropane or filtered air by inhalation for either a single 8-hour session, or 8 h daily for 4 weeks. Motor nerve conduction velocity and distal latency were measured in the tail. At the end of the experiment, the animals were decapitated, and the hippocampus, liver, and blood were collected. Exposure to 1-bromopropane for 4 weeks increased distal latency in the tail nerve significantly in F344 and marginally in WNA/NUM. It also increased total and direct bilirubin in both rat strains. Eight-hour exposure increased metallothionein 2A, metallothionein 1 and NAD(P)H quinone dehydrogenase 1 expression in the liver of both rat strains, whereas 4-week exposure upregulated glutathione S-transferase alpha 3 and CD36 molecule in the liver of both strains. KEGG analysis showed that 8-hr 1-bromopropane upregulated pathways of apoptosis, NOD-like receptor signaling and colorectal cancer, in both the hippocampus and liver, whereas 4-week exposure upregulated NOD-like receptor signaling pathway both in the hippocampus and liver of the two rat strains. Insulin signaling pathway was upregulated persistently in the hippocampus of the two rat strains. Our results suggest the involvement of immune system/inflammation-related pathway in the neuro- and hepato-toxicity of 1-bromopropane and the involvement of insulin signaling pathway in the neurotoxicity of 1-brromopropane.
In vivo toxicity and safety evaluation of Calcium-Ion functionalized silica nanocomposites in Drosophila melanogaster for biomedical applications
M. S. Marvaan, Anisha Saha, Sahabudeen Sheik Mohideen, Balashanmugan Pannerselvam, G. Devanand Venkatasubbu
Chemical Papers, 2026
Encapsulation of L. fermentum with chitosan-alginate enhances its bioactivity against acrylamide toxicity in D.mel
Swetha Senthil Kumar, Sahabudeen Sheik Mohideen
Scientific Reports, 2025
Acrylamide (ACR), a neurotoxin typically present in thermally processed foods, is a substantial risk to people. The objective of this research is to develop synbiotic capsules with natural substances such as chitosan, alginate, and L. fermentum. Encapsulation is a significant tool in medicine, helping to improve targeted medication delivery and bioavailability. The chitosan/alginate-encapsulated probiotic (CAP) beads increase the bioavailability of probiotics in the gut, allowing for a more effective response to ACR-induced toxicity. The combination of prebiotic and probiotic activity improves stability, viability, and gastrointestinal delivery. We developed CAP beads and assessed their survivability under simulated gastrointestinal conditions, encapsulating efficiency, and release profile. The efficacy of these beads in reducing the harmful effects of ACR was subsequently investigated using a Drosophila melanogaster model. Under co-exposure and pre-treatment settings, in vivo studies revealed restoration of locomotor activities, redox balance, and ovarian mitochondrial membrane potential in flies treated with CAP beads. Furthermore, implying the indirect impact of CAP beads on gut microbiota and xenobiotic metabolism, pre-treatment with CAP more successfully restored the expression of important antioxidant and stress-related genes, including sod, cat, InR, rpr, and p53.
Polyethylene microplastics induce behavioural and developmental deficits in the Drosophila model
Sharine Priscilla, Ryo Nagasawa, Swetha Senthil Kumar, Sai Charan Kasavaraju, Chirayu Chandrakanth, Premkumar Sivakumar, Hamsini Bharat, Iyeswaran Muthulingam, Masakazu Umezawa, Sahabudeen Sheik Mohideen
Toxicology and Environmental Health Sciences, 2025
Introduction Polyethylene (PE) is a common plastic used in a variety of applications such as bottles, carry bags, and packaging materials. The extensive use and improper disposal of PE MPs have severe environmental impacts. PE MPs infiltrate ecosystems via wastewater discharge and landfill runoff, getting consumed by organisms and causing harmful bioaccumulation. These microplastics also absorb toxins and transport them up the food chain, posing health risks to humans. Objectives and methods We generated PE MPs with sizes between 2 and 10 μm and assessed their toxicity on the Drosophila model. The study included an evaluation of the survival patterns of adult flies and behavioural and biochemical parameters in larvae and adults. Results Our in vivo toxicological assessment revealed a severe decline in the longevity of flies and locomotory function in the larvae and adults. In addition, we also noticed a decrease in the fly eclosion rate and a substantial increase in the antioxidant enzyme activity. This result was further supported by the alterations observed in the transcriptional activation of stress response genes like Hsp70Bc, rpr, cat, p53 and sod. Conclusion The findings from the study reveal perspectives on the harmful impacts of PE MPs on flies’ growth and development, as well as the rising threat to our environment posed by these microplastics. Graphical abstract
“The role of long non-coding RNAs in mediating epigenetic changes induced by bisphenol A Exposure: Focus on reproductive and neurodevelopmental outcomes”
Yash Banabakode, Sharine Priscilla, Kunka Mohanram Ramkumar, Satish Ramalingam, Sahabudeen Sheik Mohideen
Biochemical and Biophysical Research Communications, 2025
Low molecular weight chitosan attenuates acrylamide-induced toxicity in Drosophila melanogaster
Swetha Senthil Kumar, Sahabudeen Sheik Mohideen
Toxicology Reports, 2025
Acrylamide (ACR), a toxic by-product of high-temperature food processing, poses significant health risks due to its oxidative, neurotoxic, and genotoxic properties. Regulatory measures focus on limiting ACR in commercial food products, yet daily cooking practices often result in unnoticed exposure, threatening vulnerable populations such as children. This study evaluates the protective role of low and medium molecular-weight (MW) chitosan against ACR-induced toxicity using Drosophila melanogaster . Chitosan, a natural polysaccharide with antioxidant and prebiotic properties, was supplemented alongside ACR exposure in larvae and adult flies. Developmental metrics such as pupation rates, fecundity, and adult emergence were assessed, alongside oxidative stress markers and neurobehavioral outcomes. ACR exposure impaired development, increased oxidative stress, and reduced locomotor activity. Supplementation with low and medium MW chitosan alleviated these effects, with low MW chitosan demonstrating greater efficacy. These findings reveal the potential of low MW chitosan as a dietary intervention to counteract the toxic effects of contaminants like ACR. By reducing oxidative stress, preserving mitochondrial function, and supporting developmental processes, chitosan offers a promising avenue for mitigating the overall toxicity of heat-processed toxins. These findings further highlight chitosan's molecular weight-dependent protective potential against ACR toxicity, offering insights into its application as a dietary mitigator of heat-processed toxins. • Low MW chitosan (LC) mitigates acrylamide (ACR) toxicity, restoring survival, behaviour, and development in flies. • Medium molecular weight (MW) chitosan (MC) shows limited recovery, with oxidative stress at higher concentrations. • ACR+LC reverses mitochondrial depolarization and improves fecundity in flies. • ACR-induced deficits in redox and AChE activity are attenuated by LC co-treatment. • LC's therapeutic efficacy outperforms MC, highlighting its potential in toxicology.
Chitosan-coated titanium dioxide nanoparticles: fabrication, characterisation and toxicological evaluation in Drosophila melanogaster
Sharine Priscilla, G. Devanand Venkatasubbu, Sahabudeen Sheik Mohideen
Nanotechnology for Environmental Engineering, 2025
Correction: Chitosan-coated titanium dioxide nanoparticles: fabrication, characterisation and toxicological evaluation in Drosophila melanogaster (Nanotechnology for Environmental Engineering, (2025), 10, 2, (20), 10.1007/s41204-025-00422-y)
Sharine Priscilla, G. Devanand Venkatasubbu, Sahabudeen Sheik Mohideen
Nanotechnology for Environmental Engineering, 2025
Toxicity of Yttrium-Doped Cerium Nanocomposite in Drosophila Melanogaster
Anisha Saha, G. Devanand Venkatasubbu, Sahabudeen Sheik Mohideen
Nano, 2025
Cerium oxide (CeO[Formula: see text] and yttrium oxide (Y2O[Formula: see text] nanoparticles possess interesting surface properties and interfacial interactions that make them attractive candidates for various applications. This study presents a comprehensive investigation into the synthesis and toxicity assessment of yttrium-doped cerium oxide (Ce-Y) nanocomposite using a combination of analytical techniques and biological assays. The nanocomposite was characterized using UV–Vis spectroscopy, X-ray diffraction (XRD), Fourier-transform infrared spectroscopy (FTIR), electron microscopy imaging, dynamic light scattering (DLS), and zeta potential measurements to elucidate their structural, optical and physicochemical properties. The synthesized nanocomposite exhibited distinctive absorption spectra and precise alignment of diffraction peaks, confirming the successful incorporation of yttrium ions into the cerium oxide lattice. Electron microscopy images revealed well-dispersed yttrium particles within the ceria matrix, indicating uniform distribution and morphology. DLS and zeta potential analysis provided insights into the size distribution and stability of the nanocomposite. Furthermore, in vivo toxicity assessment using Drosophila melanogaster model revealed no significant toxicity of Ce:Y nanocomposite, as evidenced by survival assay and behavioral assays. Superoxide dismutase (SOD) activity and reactive oxygen species (ROS) levels were also evaluated, demonstrating no discernible nanoparticle-induced toxicity. Overall, this study highlights the potential applications of Ce:Y nanocomposite and underscores the importance of comprehensive toxicity evaluation in nanomaterial development.
Chitosan-Coated Titanium Dioxide Nanoparticles for Antimicrobial Applications
Sharine Priscilla, G. Devanand Venkatasubbu, Sahabudeen Sheik Mohideen
Nano, 2025
Modern cosmetic products, with rich formulations of components, have become an ideal breeding ground for microorganisms. Implementing effective preservative systems is crucial to prevent microbial growth and contamination. Titanium dioxide nanoparticles, a familiar ingredient in cosmetics, can decompose the outer membrane of microbial cells by producing free radicals. Chitosan has shown antimicrobial activities by impairing cell wall integrity by binding to it aiding in the release of cytosolic contents. In line with this, this work was centered on evaluating the antimicrobial efficiency of chitosan-coated titanium dioxide (CS-TiO[Formula: see text] nanoparticles against three bacterial species viz. Pseudomonas aeruginosa (P. aeruginosa), Staphylococcus aureus (S. aureus) and Escherichia coli (E. coli) and use them as a self-preservative agent in cosmetic formulations. The growth curve analysis exhibited a dose-dependent delay in bacterial growth. The minimum inhibitory concentration (MIC[Formula: see text] results revealed that the nanoparticles were effective at 31.25[Formula: see text][Formula: see text]g/ml and 62.5[Formula: see text][Formula: see text]g/ml concentrations in suppressing S. aureus, P. aeruginosa and E. coli, respectively. The redox imbalance, membrane lipid peroxidation, DNA damage and cell viability analyses showed that the CS-TiO2 nanoparticles could disrupt the membrane leading to reactive oxygen species (ROS) formation and altering the genetic material. Therefore, the conclusions drawn from this research highlight the proficient microbial performance of CS-TiO2, proposing its suitability for incorporation into consumer products, especially cosmetics. As far as the authors are aware, this study is believed to be the first to investigate the potential of CS-TiO2 nanoparticles as a self-preservative.
Chitosan-coated probiotic nanoparticles mitigate acrylamide-induced toxicity in the Drosophila model
Swetha Senthil Kumar, Sahabudeen Sheik Mohideen
Scientific Reports, 2024
Synthesis and antimicrobial activity of yttrium-doped cerium oxide nano-composite against wound pathogen
Anisha Saha, G Devanand Venkatasubbu, Sahabudeen Sheik Mohideen
Materials Research Express, 2024
Polyethylene microplastics affect behavioural, oxidative stress, and molecular responses in the Drosophila model
Himanshu Ranjan, Swetha Senthil Kumar, Sharine Priscilla, Subhashini Swaminathan, Masakazu Umezawa, Sahabudeen Sheik Mohideen
Environmental Science Processes and Impacts, 2024
Significance of microbial genome in environmental remediation
Vaidhegi Kugarajah, Kamaldeen Nasrin Nisha, R. Jayakumar, S. Sahabudeen, P. Ramakrishnan, S.B. Mohamed
Microbiological Research, 2023
Influence of probiotics, synbiotics, and heat-killed Lactobacillus fermentum on ageing using Drosophila model – A preliminary study
Swetha Senthil Kumar, Sharine Priscilla, Pranjali Srivastava, Teresa Cherian, Jesal Movani, Urmisha Banerjee, Pallavi Dan, Sahabudeen Sheik Mohideen
Journal of Applied Pharmaceutical Science, 2023
Exosomes Derived from Metastatic Colon Cancer Cells Induced Oncogenic Transformation and Migratory Potential of Immortalized Human Cells
Yasodha Kesavan, Sheik Mohideen Sahabudeen, Satish Ramalingam
International Journal of Experimental Research and Review, 2023
Influence of fruits and vegetables waste pre-treatment on black soldier fly larval growth
Bulla Humpy, Swetha Kumar, Sahabudeen Mohideen
Journal of Advanced Biotechnology and Experimental Therapeutics, 2023
A systematic review on the effects of acrylamide and bisphenol A on the development of Drosophila melanogaster
Swetha Senthil Kumar, Abhinaya Swaminathan, Mohamed M. Abdel-Daim, Sahabudeen Sheik Mohideen
Molecular Biology Reports, 2022
Controlled decoration of nanoceria on the surface of MoS2nanoflowers to improve the biodegradability and biocompatibility in Drosophila melanogaster model
Chandran Murugan, Vignesh Sundararajan, Sahabudeen Sheik Mohideen, Anandhakumar Sundaramurthy
Nanotechnology, 2022
Safety studies of polyethylene glycol–hydroxyapatite nanocomposites on Drosophila melanogaster: an in vivo model
Pallavi Dan, Swetha Senthilkumar, Devanand Venkatsubbu Gopinath, Sahabudeen Sheik Mohideen
Applied Nanoscience Switzerland, 2022
To comprehend the influence of annealing temperature on cerium oxide nanoparticles and its subsequent toxic effects using Drosophila melanogaster model
Ajay S Kumar, Vignesh Sundararajan, Devanand G Venkatasubbu, Sahabudeen Sheik Mohideen
Materials Today Proceedings, 2022
Intestinal microbial dysbiosis induced tau accumulation establishes a gut-brain correlation for pathology Alzheimer's disease in Drosophila melanogaster
Ankita Srivastav, Sahabudeen Sheik Mohideen
Alzheimer S Dementia the Journal of the Alzheimer S Association, 2021
Pathogenic tauR406W induced neurodegeneration and memory deficits rescued by HDAC6 null mutation in Drosophila melanogaster
Arkajyoti Sarkar, Sahabudeen Sheik Mohideen
Alzheimer S Dementia the Journal of the Alzheimer S Association, 2021
Role of cerium oxide nanoparticles in improving oxidative stress and developmental delays in Drosophila melanogaster as an in-vivo model for bisphenol a toxicity
Arkajyoti Sarkar, Tharun Selvam Mahendran, Aasha Meenakshisundaram, Rushenka Vashti Christopher, Pallavi Dan, Vignesh Sundararajan, Nishant Jana, Devanand Venkatasubbu, Sahabudeen Sheik Mohideen
Chemosphere, 2021
Investigation of therapeutic potential of cerium oxide nanoparticles in Alzheimer’s disease using transgenic Drosophila
Vignesh Sundararajan, G. Devanand Venkatasubbu, Sahabudeen Sheik Mohideen
3 Biotech, 2021
Exosomes isolated from two different cell lines using three different isolation techniques show variation in physical and molecular characteristics
Manish Dash, Kanagaraj Palaniyandi, Satish Ramalingam, S. Sahabudeen, N.S. Raja
Biochimica Et Biophysica Acta Biomembranes, 2021
Thymoquinone as a potential therapeutic for Alzheimer’s disease in transgenic Drosophila melanogaster model
NARAYANAN NAMPOOTHIRI V. P., VIGNESH SUNDARARAJAN, PALLAVI DAN, G. DEVANAND VENKATASUBBU, SAHABUDEEN SHEIK MOHIDEEN
Biocell, 2021
Investigation on photo-induced mechanistic activity of GO/TiO2 hybrid nanocomposite against wound pathogens
Jayabal Prakash, Kannan Sampath Kumar Venkataprasanna, Darmalingam Prema, Sheik Mohideen Sahabudeen, Samal Debashree Banita, Gopinath Devanand Venkatasubbu
Toxicology Mechanisms and Methods, 2020
Developmental and behavioural toxicity induced by acrylamide exposure and amelioration using phytochemicals in Drosophila melanogaster
Swetha Senthilkumar, Rakshika Raveendran, Sayooj Madhusoodanan, Malini Sundar, Siddhi Shree Shankar, Suyash Sharma, Vignesh Sundararajan, Pallavi Dan, Sahabudeen Sheik Mohideen
Journal of Hazardous Materials, 2020
Mechanism of inhibition of graphene oxide/zinc oxide nanocomposite against wound infection causing pathogens
D. Prema, J. Prakash, S. Vignesh, Pandiyarasan Veluchamy, C. Ramachandran, Debashree Banita Samal, Deog-Hwan Oh, S. Sahabudeen, G. Devanand Venkatasubbu
Applied Nanoscience Switzerland, 2020
Fabrication of Chitosan/PVA/GO/CuO patch for potential wound healing application
K.S. Venkataprasanna, J. Prakash, S. Vignesh, G. Bharath, Manigandan Venkatesan, Fawzi Banat, S. Sahabudeen, Saravanan Ramachandran, G. Devanand Venkatasubbu
International Journal of Biological Macromolecules, 2020
Drosophila melanogaster as an in vivo model to study the potential toxicity of cerium oxide nanoparticles
Vignesh Sundararajan, Pallavi Dan, Ajay Kumar, G. Devanand Venkatasubbu, Sahoko Ichihara, Gaku Ichihara, Sahabudeen Sheik Mohideen
Applied Surface Science, 2019
Evaluation of hydroxyapatite nanoparticles - induced in vivo toxicity in Drosophila melanogaster
Pallavi Dan, Vignesh Sundararajan, Harsana Ganeshkumar, Barathan Gnanabarathi, Arun Kumar Subramanian, G. Devanand Venkatasubu, Sahoko Ichihara, Gaku Ichihara, Sahabudeen Sheik Mohideen
Applied Surface Science, 2019
Synthesis of Positively and Negatively Charged CeO2 Nanoparticles: Investigation of the Role of Surface Charge on Growth and Development of Drosophila melanogaster
Divya Parimi, Vignesh Sundararajan, Omer Sadak, Sundaram Gunasekaran, Sahabudeen Sheik Mohideen, Anandhakumar Sundaramurthy
ACS Omega, 2019
Poly herbal formulation with anti-elastase and anti-oxidant properties for skin anti-aging
Induja Kalyana Sundaram, Deepika Deeptirekha Sarangi, Vignesh Sundararajan, Shinomol George, Sahabudeen Sheik Mohideen
BMC Complementary and Alternative Medicine, 2018
Investigation of cytotoxicity induced by Nigella sativa and Azadirachta indica using MDA-MB-231, HCT 116 and SHSY5Y cell lines
Sayani Banerjee, Shefali Pandey, Purbasha Mukherjee, Afia Sayeed, Apoorva Vasant Pandurangi, Shinomol George, Sahabudeen Sheik Mohideen
Pharmacognosy Journal, 2017
Nontoxic singlet oxygen generator as a therapeutic candidate for treating tauopathies
Sahabudeen Sheik Mohideen, Yasutoyo Yamasaki, Yasuhiro Omata, Leo Tsuda, Yuji Yoshiike
Scientific Reports, 2015
Rats with metabolic syndrome resist the protective effects of N-acetyl l-cystein against impaired spermatogenesis induced by high-phosphorus/zinc-free diet
Yuka Suzuki, Gaku Ichihara, Sheik Mohideen Sahabudeen, Ai Kato, Takanori Yamaguchi, Kyoko Imanaka-Yoshida, Toshimichi Yoshida, Yoshiji Yamada, Sahoko Ichihara
Experimental and Toxicologic Pathology, 2013
Effects of sub-acute and sub-chronic inhalation of 1-bromopropane on neurogenesis in adult rats
Lingyi Zhang, Taku Nagai, Kiyofumi Yamada, Daisuke Ibi, Sahoko Ichihara, Kaviarasan Subramanian, Zhenlie Huang, Sahabudeen Sheik Mohideen, Hisao Naito, Gaku Ichihara
Toxicology, 2013
Effects of exposure to 1-bromopropane on astrocytes and oligodendrocytes in rat brain
Sahabudeen Sheik Mohideen, Sahoko Ichihara, Kaviarasan Subramanian, Zhenlie Huang, Hisao Naito, Junzoh Kitoh, Gaku Ichihara
Journal of Occupational Health, 2013
Exposure to 1-bromopropane induces microglial changes and oxidative stress in the rat cerebellum
Kaviarasan Subramanian, Sahabudeen Sheik Mohideen, Akio Suzumura, Naoya Asai, Yoshiki Murakumo, Masahide Takahashi, Shijie Jin, Lingyi Zhang, Zhenlie Huang, Sahoko Ichihara, Junzoh Kitoh, Gaku Ichihara
Toxicology, 2012
Proteomic identification of carbonylated proteins in F344 rat hippocampus after 1-bromopropane exposure
Zhenlie Huang, Sahoko Ichihara, Shinji Oikawa, Jie Chang, Lingyi Zhang, Kaviarasan Subramanian, Sahabudeen Sheik Mohideen, Gaku Ichihara
Toxicology and Applied Pharmacology, 2012
Proteomic analysis of hippocampal proteins of F344 rats exposed to 1-bromopropane
Zhenlie Huang, Sahoko Ichihara, Shinji Oikawa, Jie Chang, Lingyi Zhang, Masahide Takahashi, Kaviarasan Subramanian, Sahabudeen Sheik Mohideen, Yun Wang, Gaku Ichihara
Toxicology and Applied Pharmacology, 2011
Exposure to 1-bromopropane causes degeneration of noradrenergic axons in the rat brain
Sahabudeen Sheik Mohideen, Gaku Ichihara, Sahoko Ichihara, Shoji Nakamura
Toxicology, 2011
Increased susceptibility of Nrf2-Null Mice to 1-bromopropane-induced hepatotoxicity
Fang Liu, Sahoko Ichihara, William M. Valentine, Ken Itoh, Masayuki Yamamoto, Sahabudeen Sheik Mohideen, Junzoh Kitoh, Gaku Ichihara
Toxicological Sciences, 2010
Comparative study on susceptibility to 1-bromopropane in three mice strains
Fang Liu, Sahoko Ichihara, Sahabudeen Sheik Mohideen, Uka Sai, Junzoh Kitoh, Gaku Ichihara
Toxicological Sciences, 2009
Changes in neurotransmitter receptor expression levels in rat brain after 4-week exposure to 1-bromopropane
Sahabudeen Sheik Mohideen, Sahoko Ichihara, Shameema Banu, Fang Liu, Junzoh Kitoh, Gaku Ichihara
Neurotoxicology, 2009
Spermatotoxic effect of aflatoxin B1 in rat: Extrusion of outer dense fibres and associated axonemal microtubule doublets of sperm flagellum
K Faisal, V S Periasamy, S Sahabudeen, A Radha, R Anandhi, M A Akbarsha
Reproduction, 2008

Sahabudeen Sheik Mohideen

RESEARCH INTERESTS

Scopus Publications