A Comprehensive Review Highlighting the Prospects of Phytonutrient Berberine as an Anticancer Agent Shafiul Haque, Darin Mansor Mathkor, Sajad Ahmad Bhat, Abdugani Musayev, Lidiya Khituova, Seema Ramniwas, Enosh Phillips, Nitin Swamy, Suneel Kumar, Mukerrem Betul Yerer, Hardeep Singh Tuli, Vikas Yadav Journal of Biochemical and Molecular Toxicology, 2025 Berberine, an isoquinoline alkaloid derived from various medicinal plants, emerges as a potential therapeutic agent against diverse human diseases. It has particularly shown notable anticancer efficacy against breast, colorectal, lung, prostate, and liver cancer. Berberine results in inhibition of cancer cell proliferation, induction of apoptosis, and suppressing angiogenesis, positioning it as a versatile, multitargeted therapeutic tool against cancer. Notably, berberine enhances the effectiveness of conventional chemotherapeutic drugs, mitigating associated drug resistance. Mechanistically, it has been shown to exert its efficacy by targeting molecules like nuclear factor‐kappa B (NF‐κB), mitogen‐activated protein kinases (MAPKs), and phosphoinositide 3‐kinase (PI3K)/Akt, thereby inhibiting survival pathways and promoting apoptosis of cancer cells. Moreover, berberine influences the expression of tumor suppressor genes, curtails cancer cell migration and invasion, and modulates the tumour microenvironment. Despite promising preclinical evidence, further research is essential to comprehensively elucidate its mechanisms of action and evaluate its safety and efficacy in clinical settings. In the present review, we have highlighted the pharmacokinetics, biosynthesis, and recent research work done pertaining to berberine's strong anticancer activity. We have also emphasised on the research being done on nanoformulations of berberine, which aim to improve its stability and bioavailability.
Biochar Application for Removal of Heavy Metals and Organic Pollutants from Soil Snehal Narkhede, Enosh Phillips, Akansha Singhai, Ashish Dadsena, Reecha Sahu, Tanvir Arfin, Amita Shakya, Piyush Parkhey ACS Symposium Series, 2024 The increasing population raises the demand for products, increasing industrialization, modernization and energy utilization. Due to this, heavy metal contamination in the environment has paced up. Heavy metals are toxic to life forms and are non-biodegradable. Several methods, such as adsorption, ion exchange, chemical precipitation, and reverse osmosis, have been adopted for its removal. Adsorption is most favored; however, its usage is limited, given non-eco-friendly adsorbents. Regarding this, biochar is one of the promising, biodegradable, and non-toxic adsorbents available. Biochar is a porous material primarily prepared from bio-waste. Thermochemical processes produce the biochar for biomass conversion into biofuels and other bio-based products such as carbonization, pyrolysis and gasification. Due to its excellent surface area, porous structure, ample surface operational groups and large cation exchange capacities, biochar is an effective adsorbent for pollutants. It has been widely used to remove organic pollutants and heavy metals. Recently, a study reported using AI (Artificial Intelligence) with biochar to remove heavy metals. In the case of organic pollutants, biochar has been extensively studied for wastewater remediation. Therefore, this review presents comprehensive data focusing on using biochar for bioremediate organic pollutants and heavy metals.
Microbial fuel cells: Whole-cell system for MFC, current trends, and future prospects for the green energy Whole Cell Biocatalysis Next Generation Technology for Green Synthesis of Pharmaceutical Chemicals and Biofuels, 2024
Biobutanol Production and Advancement Enosh Phillips Bioenergy Research Evaluating Strategies for Commercialization and Sustainability, 2021 The present economy depends upon petroleum fuel. The concerns are rising worldwide with the depletion of fossil fuels, which includes petroleum. Moreover, combustion of petroleum has continuously affected the environment by raising the concentration of greenhouse gases like CO, CO2, and N2O. Biofuels are the alternative fuels developed from biomass. Biofuels have oxygen levels up to 45%, whereas petroleum has none. Although biodiesel and bioethanol dominate the biofuel market, they have several disadvantages. These are overcome by biobutanol. Clostridium sp. has been vital in biobutanol production. It produces butanol via the ABE method. Annually, biomass is produced in millions of tons by photosynthetic organisms, mainly by plants. Biomass may contain different amounts of polysaccharide useful for biobutanol production. Pretreatment plays an important role in increasing the yield. Since the inception of the idea for the bioproduction of butanol as an alternative fuel, many developments have taken place to enhance production and make the process efficient.
Biohydrogen Production from Cellulosic Waste Biomass Enosh Phillips Bioenergy Research Evaluating Strategies for Commercialization and Sustainability, 2021 Hydrogen is the most abundant element present on earth. It is a promising fuel of the future, as its production is the solution for environmental problems developed due to the use of fossil-based fuel. Sir William Robert Groove of Wales is credited for the invention of the first hydrogen-based fuel cell. In terms of energy content, H2 has the maximum energy value as compared to methane, ethanol, and methanol, as well as other biofuels. The energy value of H2 is 142 KJ g−1. Thus, it can be used for direct combustion in internal combustion engines and as fuel in fuel cells. Cellulose is found abundantly in nature and is synthesized by a wide range of living organisms, from bacterias to trees. It is a polymer, composed of D-anhydroglucose rings joined together by β-1,4 glycosidic oxygen linkages. It can be used for hydrogen production. Billions of tons of cellulosic waste are produced every year and if enacted properly, they then can be used for efficient bio-H2 production. The biological approach for biohydrogen production is much more acceptable than conventional methods like thermochemical and electrochemical, as the former requires less energy input and is environmentally friendly. Pretreatment plays a vital role in bio-H2 production along with temperature and pH. Wheat and rice bran, straw, de-oiled jatropha, and rice bran leaves can all be used for hydrogen production. From cellulosic waste, an estimated amount of 3–4.5 mol of H2/glucose molecule is reported. Bio-H2 is the future fuel and much of its production depends on finding cellulosic waste, as it is easy to collect and is inexpensive, decreasing the production cost and supporting its use to replace fossil fuel.
In-process synthesis of sulfur-free nano-lignin during organosolv extraction from rice husk and straw: process optimization, functionality, and valorization potential E Phillips, R Sahu, P Parkhey, V Kolla, LK Pandey, PK Pandey, ... 2026.0
Isolation and enumeration of bacteria from fresh flowers of the religious city of Ayodhya in the state of Uttar Pradesh in India AT Ranjan Singh, Prashant Singh, Ajad Patel, Vinay Singh Baghel, Vijay Kumar ... Acta Scientific Microbiology 8 (3), 52-57 , 2025 2025.0
Agro-Waste based Antibacterial Cellulosic Nanogel for Heavy Metal Adsorption from Contaminated Water S Narkhede, P Parkhey, E Phillips, A Dadsena, A Singhai, V Kolla, ... Journal of Chemical Health Risks 15 (2), 577-596 , 2025 2025.0 Citations: 1
Development of Lignin–PVA Hydrogel and Its Application in Lead Removal for Waste Water Treatment. E Phillips, R Sahu, P Parkhey, V Kolla, LK Pandey, PK Pandey, ... Journal of Chemical Health Risks 15 (2), 567-576 , 2025 2025.0 Citations: 1
A Comprehensive Review Highlighting the Prospects of Phytonutrient Berberine as an Anticancer Agent VY Shafiul Haque, Darin Mansor Mathkor, Sajad Ahmad Bhat, Abdugani Musayev ... Journal of Biochemical and Molecular Toxicology 39 (1) , 2024 2024.0 Citations: 10
Green Synthesis of Silver Nanoparticles for Arsenic (III) Removal from Contaminated Water RS Snehal Narkhede, Piyush Parkhey, Ashish Dadsena, Akansha Singhai, Enosh ... Journal of Chemical Health Risks 14 (6) , 2024 2024.0 Citations: 5
Analysis Of The Anti-Oxidant And Cell Cytotoxicity Properties Of Stevia Rebaudiana Extract By Using In-Vitro Model. LK Pandey, N Varshney, P Joshi, N Swamy, E Phillips, R Singh, Z Baksh Journal of Advanced Zoology 45 (5) , 2024 2024.0
Microbial Fuel Cells: Whole-Cell System for MFC, Current Trends, and Future Prospects for the Green Energy E Phillips, M Bharadwaj, R Sahu, P Parkhey Whole-Cell Biocatalysis 1, 377-392 , 2024 2024.0
Utilization of Agro-Waste for Lignin Production and Assessment of Its Antibacterial Activity E Phillips, P Parkhey, S Narkhede, A Dadsena, A Singhai, M Bhardwaj, ... Journal of Chemical Health Risks 14 (6), 2465-2471 , 2024 2024.0
Removal of Inorganic and Organic Pollutants from Soil by Biochar Application: A Sustainable Approach to Improve Soil Health S Narkhede, E Phillips, A Singhai, A Dadsena, R Sahu, T Arfin, A Shakya, ... Catalytic Applications of Biochar for Environmental Remediation: Sustainable … , 2024 2024.0 Citations: 6
Nanotechnological interventions in biofuel production E Phillips Handbook of Biofuels, 593-604 , 2022 2022.0 Citations: 6
Biohydrogen production from cellulosic waste biomass E Phillips Bioenergy Research: Evaluating Strategies for Commercialization and … , 2021 2021.0 Citations: 3
Biobutanol production and advancement E Phillips Bioenergy Research: Evaluating Strategies for Commercialization and … , 2021 2021.0 Citations: 3
Algal butanol production E Phillips Substrate analysis for effective biofuels production, 33-50 , 2020 2020.0 Citations: 4
Algal nanotech for biofuel production E Phillips AGRICA Учредители: Diva Enterprises Private Limited 9 (1), 1 , 2020 2020.0 Citations: 3
Genetic engineering applications to improve cellulase production and efficiency: Part I E Phillips New and future developments in microbial biotechnology and bioengineering … , 2019 2019.0 Citations: 10
Evaluating the Efficacy of Moringa oleifera-Mediated Zinc Oxide Nanoparticles for Antifouling and Wound Healing Applications A Singhai, S Narkhede, E Phillips, A Dadsena, R Sahu Citations: 1
Synthesis and Characterization of" Keratin-Alginate/ZnO Nanogel: An Innovative Antimicrobial System for Enhanced Wound Healing A Singhai, S Narkhede, E Phillips, A Dadsena, R Sahu, A Sur
MOST CITED SCHOLAR PUBLICATIONS
A Comprehensive Review Highlighting the Prospects of Phytonutrient Berberine as an Anticancer Agent VY Shafiul Haque, Darin Mansor Mathkor, Sajad Ahmad Bhat, Abdugani Musayev ... Journal of Biochemical and Molecular Toxicology 39 (1) , 2024 2024.0 Citations: 10
Genetic engineering applications to improve cellulase production and efficiency: Part I E Phillips New and future developments in microbial biotechnology and bioengineering … , 2019 2019.0 Citations: 10
Removal of Inorganic and Organic Pollutants from Soil by Biochar Application: A Sustainable Approach to Improve Soil Health S Narkhede, E Phillips, A Singhai, A Dadsena, R Sahu, T Arfin, A Shakya, ... Catalytic Applications of Biochar for Environmental Remediation: Sustainable … , 2024 2024.0 Citations: 6
Nanotechnological interventions in biofuel production E Phillips Handbook of Biofuels, 593-604 , 2022 2022.0 Citations: 6
Green Synthesis of Silver Nanoparticles for Arsenic (III) Removal from Contaminated Water RS Snehal Narkhede, Piyush Parkhey, Ashish Dadsena, Akansha Singhai, Enosh ... Journal of Chemical Health Risks 14 (6) , 2024 2024.0 Citations: 5
Algal butanol production E Phillips Substrate analysis for effective biofuels production, 33-50 , 2020 2020.0 Citations: 4
Biohydrogen production from cellulosic waste biomass E Phillips Bioenergy Research: Evaluating Strategies for Commercialization and … , 2021 2021.0 Citations: 3
Biobutanol production and advancement E Phillips Bioenergy Research: Evaluating Strategies for Commercialization and … , 2021 2021.0 Citations: 3
Algal nanotech for biofuel production E Phillips AGRICA Учредители: Diva Enterprises Private Limited 9 (1), 1 , 2020 2020.0 Citations: 3
Agro-Waste based Antibacterial Cellulosic Nanogel for Heavy Metal Adsorption from Contaminated Water S Narkhede, P Parkhey, E Phillips, A Dadsena, A Singhai, V Kolla, ... Journal of Chemical Health Risks 15 (2), 577-596 , 2025 2025.0 Citations: 1
Development of Lignin–PVA Hydrogel and Its Application in Lead Removal for Waste Water Treatment. E Phillips, R Sahu, P Parkhey, V Kolla, LK Pandey, PK Pandey, ... Journal of Chemical Health Risks 15 (2), 567-576 , 2025 2025.0 Citations: 1
Evaluating the Efficacy of Moringa oleifera-Mediated Zinc Oxide Nanoparticles for Antifouling and Wound Healing Applications A Singhai, S Narkhede, E Phillips, A Dadsena, R Sahu Citations: 1
In-process synthesis of sulfur-free nano-lignin during organosolv extraction from rice husk and straw: process optimization, functionality, and valorization potential E Phillips, R Sahu, P Parkhey, V Kolla, LK Pandey, PK Pandey, ... 2026.0
Isolation and enumeration of bacteria from fresh flowers of the religious city of Ayodhya in the state of Uttar Pradesh in India AT Ranjan Singh, Prashant Singh, Ajad Patel, Vinay Singh Baghel, Vijay Kumar ... Acta Scientific Microbiology 8 (3), 52-57 , 2025 2025.0
Analysis Of The Anti-Oxidant And Cell Cytotoxicity Properties Of Stevia Rebaudiana Extract By Using In-Vitro Model. LK Pandey, N Varshney, P Joshi, N Swamy, E Phillips, R Singh, Z Baksh Journal of Advanced Zoology 45 (5) , 2024 2024.0
Microbial Fuel Cells: Whole-Cell System for MFC, Current Trends, and Future Prospects for the Green Energy E Phillips, M Bharadwaj, R Sahu, P Parkhey Whole-Cell Biocatalysis 1, 377-392 , 2024 2024.0
Utilization of Agro-Waste for Lignin Production and Assessment of Its Antibacterial Activity E Phillips, P Parkhey, S Narkhede, A Dadsena, A Singhai, M Bhardwaj, ... Journal of Chemical Health Risks 14 (6), 2465-2471 , 2024 2024.0
Synthesis and Characterization of" Keratin-Alginate/ZnO Nanogel: An Innovative Antimicrobial System for Enhanced Wound Healing A Singhai, S Narkhede, E Phillips, A Dadsena, R Sahu, A Sur
