Exploring the antimicrobial potential of Leukocyte- and Platelet-Rich Fibrin – an in vitro study António Melo‐Ferraz, Paulo Miller, Maria Begoña Criado, Maria Céu Monteiro, Cristina Coelho APMIS, 2024 This study investigates the antimicrobial properties of leukocyte‐ and platelet‐rich fibrin (L‐PRF) against Enterococcus faecalis (ATCC 29212), Pseudomonas aeruginosa (ATCC 27853), and Candida albicans (ATCC 90028). Infections can hinder wound healing posing challenges. L‐PRF's potential for regeneration and antimicrobial action has been studied. Considering the increasing concern about antibiotic resistance, assessing the antimicrobial properties of L‐PRF provides valuable insights into its potential as a therapeutic agent in postoperative infections. Twenty volunteers were enrolled in the study, following ethical guidelines, and obtaining informed consent. Blood samples were collected and L‐PRF was prepared. Microbial suspensions were prepared, and susceptibility testing was performed using the Kirby‐Bauer agar diffusion method. The study revealed significant heterogeneity in the susceptibility to L‐PRF. All L‐PRF membrane samples exhibited antimicrobial activity against P. aeruginosa, with inhibition zones of 13 mm ± 3.85 SD. Enterococcus faecalis displayed inhibition diameter of 7.25 mm ± 5.15 SD. Candida albicans susceptibility to L‐PRF varied among samples, with both inhibitory and non‐inhibitory results. Results showed varying degrees of antimicrobial activity, particularly against P. aeruginosa, and highlight the complexity of the L‐PRF‐microorganism interaction. Further investigations are needed to elucidate the clinical implications and optimize the use of L‐PRF.
Análise das publicações científicas indexadas (JCR) no âmbito da endodontia (1998-2008) PMC Miller Universitat de València, Facultat de Medicina i Odontologia, Departament d … , 2013 2013 Citations: 2
Análise das publicações científicas indexadas (JCR) no âmbito da endodontia (1998-2008)= Análisis de las publicaciones científicas indexadas (JCR) en el ámbito de la endodoncia … P Cruz Miller Análise das publicações científicas indexadas (JCR) no âmbito da endodontia … , 2013 2013 Citations: 1
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Análise das publicações científicas indexadas (JCR) no âmbito da endodontia (1998-2008) PMC Miller Universitat de València, Facultat de Medicina i Odontologia, Departament d … , 2013 2013 Citations: 2
Análise das publicações científicas indexadas (JCR) no âmbito da endodontia (1998-2008)= Análisis de las publicaciones científicas indexadas (JCR) en el ámbito de la endodoncia … P Cruz Miller Análise das publicações científicas indexadas (JCR) no âmbito da endodontia … , 2013 2013 Citations: 1
