Patricia Nivoloni Tannure
@uva.br
Professor
Universidade Veiga de Almeida
EDUCATION
PhD in Dentistry - Pediatric Dentistry
RESEARCH INTERESTS
dental caries, satisfaction, cleft lip and palate, genetics
Scopus Publications
Scholar Citations
Scholar h-index
Scholar i10-index
Scopus Publications
PATRICIA NIVOLONI TANNURE and DANIEL DEMÉTRIO FAUSTINO-SILVA
Elsevier BV
Marceli de França, Caroline Uemoto, Dennis de Carvalho Ferreira, Maíra do Prado, and Patricia Nivoloni Tannure
Universidade Estadual de Campinas
An aesthetic smile is usually associated with healthy appearance and success in many areas of life. Currently, individuals access the internet and social media in search of health information. The aim of this study was to analyse the quality and reliability of information in videos available on the YouTubeTM platform about ultra-thin ceramic laminates. Methods: YouTubeTM was searched using the therms “dental ceramic laminates” and “dental contact lens” for videos uploaded on ultra-thin ceramic laminates. The first 100 videos in Portuguese were selected and rated for quality and reliability. The content and source of videos were also noted. The quality of the videos was determined by evaluating the presence or absence of reliable information and distributed into seven domains. To compare the distributions of quantitative variables between the classifications of source, content, and quality, the Kruskal-Wallis and Dunn’s post-hoc tests were performed. Results: Seventy-two videos were included for qualitative analysis. Regarding quality rating, most videos were rated with poor quality. The reliability of the evaluated videos was low. Conclusion: YouTubeTM showed a large number of videos with many views on the topic, but it does not contribute with good quality and reliable information to the population.
Priscilla Coutinho Romualdo, Carolina Maschietto Pucinelli, Patricia Nivoloni Tannure, Paulo Nelson-Filho, Raquel Assed Bezerra Segato, João Armando Brancher, Nilza Letícia Magalhães, Marcelo de Castro Costa, Lívia Azeredo A. Antunes, Leonardo Santos Antunes,et al.
Elsevier BV
Rodrigo Antonio Modena, Patrícia Nivoloni Tannure, Vinícius Athayde Pessoa, Larissa Maria Cavalcante, and Luis Felipe Jochims Schneider
Springer Science and Business Media LLC
Erika Calvano Küchler, Lea Assed da Silva, Paulo Nelson-Filho, Ticiana M. Sabóia, Angela M. Rentschler, José Mauro Granjeiro, Driely Oliveira, Patricia N. Tannure, Raquel Assed da Silva, Leonardo Santos Antunes,et al.
FapUNIFESP (SciELO)
Abstract Objectives To evaluate the association between hypoxia during embryo development and oral clefts in an animal model, and to evaluate the association between polymorphisms in the HIF-1A gene with oral clefts in human families. Material and Methods The study with the animal model used zebrafish embryos at 8 hours post-fertilization submitted to 30% and 50% hypoxia for 24 hours. At 5 days post-fertilization, the larvae were fixed. The cartilage structures were stained to evaluate craniofacial phenotypes. The family-based association study included 148 Brazilian nuclear families with oral clefts. The association between the genetic polymorphisms rs2301113 and rs2057482 in HIF-1A with oral clefts was tested. We used real time PCR genotyping approach. ANOVA with Tukey's post-test was used to compare means. The transmission/disequilibrium test was used to analyze the distortion of the inheritance of alleles from parents to their affected offspring. Results For the hypoxic animal model, the anterior portion of the ethmoid plate presented a gap in the anterior edge, forming a cleft. The hypoxia level was associated with the severity of the phenotype (p<0.0001). For the families, there was no under-transmitted allele among the affected progeny (p>0.05). Conclusion Hypoxia is involved in the oral cleft etiology, however, polymorphisms in HIF-1A are not associated with oral clefts in humans.
T. Franco, M.D.C. Cezini, L. Metropolo, D.C. Ferreira, and P.N. Tannure
Wiley
Osteoradionecrosis (ORN) is defined as the presence of ulceration or necrosis of the mucosa with exposure of necrotic bone that does not heal within a 2-month period after radiotherapy in patients with head and neck tumours. The mandible presents a higher risk of developing ORN than the maxilla and extraction of teeth is also considered a risk factor for the development of ORN. The aim of this article was to present a clinical case where a protocol was used to prevent the development of ORN after the extraction of lower molars in an adolescent who had undergone surgical removal and radiotherapy for a mucoepidermoid carcinoma in the left parotid gland. The results showed that the protocol used was efficient in the prevention of osteoradionecrosis in this adolescent. One year after the extractions, no clinical or radiographic signs of any pathological alteration were observed in the region; the patient remains under periodical clinical and radiographic follow-up.
Macedo Pessoa Erica Alexandra, Braune Andre, Ladeira Casado Priscila, and Nivoloni Tannure Patricia
SAGE Publications
Objective The aim of this study was to investigate clinical aspects and predisposing factors for alveolar bone graft complications in persons born with oral clefts. Design A total of 105 patients, aged 7 to 57 years old, who received alveolar bone graft at the Cranio-maxillofacial Surgery Center in the National Institute of Traumatology and Orthopedics (INTO), Rio de Janeiro (RJ) from 2009 to 2014 were selected. Data were collected concerning the type of oral cleft, family history of cleft, medical and dental exam, donor area, type of graft material, repaired surgical treatment done, and postoperative follow-up examinations. Results Postoperative complications developed in 31 patients (32.9%). The mean age at grafting was 16.79 years for the group without complications (n = 63) and 20.13 years for the group with postoperative complications (n = 31). There was a positive association between age and type of graft and cases with alveolar bone graft complications. Patients aged 12 years or more had a four times more chance of developing alveolar bone graft complications. Particulate bone graft from iliac crest demonstrated better results compared with block graft or mixed graft. Conclusion Patients with cleft lip and palate who were 12 years or older had a greater chance of developing complications after grafting the alveolar bone. Furthermore, particulate alveolar graft from iliac crest had significantly better outcomes.
Marcelo BORBA, Daniel DELUIZ, Eduardo José Veras LOURENÇO, Luciano OLIVEIRA, and Patrícia Nivoloni TANNURE
FapUNIFESP (SciELO)
This study aimed to evaluate dental implant outcomes and to identify risk factors associated with implant failure over 12 years via dental records of patients attending an educational institution. Dental records of 202 patients receiving 774 dental implants from 2002 to 2014 were analyzed by adopting a more reliable statistical method to evaluate risk factors with patients as the unit [generalized estimating equation (GEE)]. Information regarding patient age at implantation, sex, use of tobacco, and history of systemic diseases was collected. Information about implant location in the arch region and implant length, diameter, and placement in a grafted area was evaluated after 2 years under load. Systemic and local risk factors for early and late implant failure were studied. A total of 18 patients experienced 25 implant failures, resulting in an overall survival rate of 96.8% (2.84% and 0.38% early and late implant failures, respectively). The patient-based survival rate was 91.8%. GEE univariate and multivariate analyses revealed that a significant risk factor for implant failure was the maxillary implant (p = 0.006 and p = 0.014, respectively). Bone grafting appeared to be a risk factor for implant failure (p = 0.054). According to GEE analyses, maxillary implants had significantly worse outcomes in this population and were considered to be a risk factor for implant failure. Our results suggested that implants placed in a bone augmentation area had a tendency to fail.
LMB Marieiro, D Deluiz, DC Ferreira, and PN Tannure
APESB (Associacao de Apoio a Pesquisa em Saude Bucal)
Objective: To identify the average number of dental implants that can be placed in the lower anterior region to support a fixed mandibular prosthesis based on the distance between the mental foramina, using a cone beam computed tomography (CBCT) scan through a new method of measurement. Material and Methods: Eighty-two CT scans from a total sample of 1,465 exams were selected. The method to measure the space between the foramina was developed using the BlueSky Plan3 software in Dicom format and the axial reconstruction views were chosen for measurements. Descriptive analysis of data was conducted categorical variables were compared using the χ2 test (p <0.05). Results: The mean age of individuals who underwent the scans was 63.51 ± 9.49 years old with a minimum and maximum age of 40 and 86 years old, respectively. The mean linear measurement between the foramina was 40.52 ± 3.92mm. In males the mean distance was 41.93 ± 3.98 mm, and for females it was 39.99 ± 3.80mm, with a significant difference between the means (p = 0.043). There was no positive association between the presence of the anterior loop and gender (p = 0.719). The results showed that the vast majority of subjects (n = 80) could be rehabilitated using a protocol with 4 implants of 3.3mm diameters. Conclusion: Seventy-seven patients would be able to receive protocols of 4 implants with diameters of 3.75 or 4.0mm, and only 4 subjects would be able to be rehabilitated with 6 implants with diameters of 3.75 mm according to the protocol originally described by Branemark.
Patricia Nivoloni Tannure and Erika Calvano Küchler
Elsevier BV
Tatiana Kelly da Silva Fidalgo, Carla Nogueira, Marcia Rejane Thomas Canabarro Andrade, Andrea Graciene Lopez Ramos Valente, and Patricia Nivoloni Tannure
Hindawi Limited
The aim of this paper is to describe a rare case report of a pediatric patient with secondary Sjögren’s syndrome (SSS). A 12-year-old female child was referred to the Pediatric Dentistry Clinic with the chief complaint of tooth pain, dry mouth, and tooth sensibility. The patient was submitted to orthodontic treatment prior to syndrome diagnosis. The clinical treatment consisted of the interruption of orthodontic treatment and restoring the oral condition with dental treatment and the use of artificial saliva in an innovative apparatus. Dental therapy involved the control of dental caries, periodontal disease, and opportunistic fungal infections and the use of fluoride-rich solutions. The present clinical case describes clinical and laboratory aspects of SSS in pediatric patients. The management of the oral findings promoted an improvement in the oral health status and quality of life of the child.
Márcia Waltrick-Zambuzzi, Patricia Nivoloni Tannure, Thays Cristine dos Santos Vieira, Leonardo Santos Antunes, Fábio Lourenço Romano, Willian Fernando Zambuzzi, José Mauro Granjeiro, and Erika Calvano Küchler
FapUNIFESP (SciELO)
The aim of this study was to evaluate the association of the polymorphisms in TCN2 (rs1801198) gene and in MTRR (rs1801394) gene with nonsyndromic cleft lip and/or palate (NSCL/P) in a Brazilian population. Genomic DNA was extracted from buccal cells. The polymorphisms in TCN2 (rs1801198) and MTRR (rs1801394) genes were genotyped by carrying out real-time PCR and Taqman assay. Chi-square test was used to determine the association between genotype and allele frequencies with NSCL/P and NSCL/P subgroups (cleft lip only, cleft lip and palate, and cleft palate only). Eight hundred and sixty seven unrelated individuals (401 cases with NSCL/P and 466 individuals without cleft) were evaluated. Genotype distributions of TCN2 and MTRR polymorphisms were in Hardy-Weinberg equilibrium. The TCN2 polymorphic genotype GG was identified in 16.7% of the NSCL/P group and in 14.1% of the non-cleft group (p>0.05). Similarly, the frequency of MTRR genotype (GG) was similar in NSCL/P group (15.5%) and control group (17.8%) (p>0.05). Multivariate analysis showed an association between MTRR and the subgroup that the mother smoked during pregnancy (p=0.039). Our findings did not demonstrate an association between TCN2 polymorphisms and NSCL/P, however suggests an association between MTRR and NSCL/P etiology
Oswaldo de Castro Costa Neto, Leandro Araujo Lobo, Natalia Lopes Pontes Iorio, Maria de Fátima Carvalho Vasconcelos, Lucianne Cople Maia, Patrícia Nivoloni Tannure, and Andréa Gonçalves Antonio
Springer Science and Business Media LLC
Helena Freire Romanos, Leonardo Santos Antunes, Ludiana Barbosa Lopes, Ticiana de Medeiros Sabóia, Patricia Nivoloni Tannure, Andrea Lips, Livia Azeredo A. Antunes, Fernanda Volpe de Abreu, Kathleen Deeley, Gutemberg Alves,et al.
S. Karger AG
Bone morphogenetic proteins (BMPs) play an important role during the initial process of enamel development and therefore may play a role in caries susceptibility. The purpose of this study was to evaluate the association between the polymorphisms in the <i>BMP2, BMP4</i> and <i>BMP7</i> genes and their association with caries experience and primary enamel microhardness characteristics. DNA from buccal cells as well as clinical and demographic information from 1,731 subjects from three different data sets from Brazil were included. Polymorphisms in <i>BMP2, BMP4</i> and <i>BMP7</i> were analyzed by real-time polymerase chain reaction from genomic DNA. Association between caries experience, genotype, and allele distribution in both cohorts was evaluated using &#x03C7;<sup>2</sup> and logistic regression analyses. In the family-based set, the association between caries experience and alleles was tested using the transmission disequilibrium test. In the Rio de Janeiro cohort, microhardness data on 108 exfoliated primary teeth before and after demineralization and remineralization challenges was included. Associations between microhardness values and genotype and allele distribution were evaluated using &#x03C7;<sup>2</sup> and logistic regression analyses. Differences between caries experience and some risk factors were statistically significant. In the cohort from Nova Friburgo, <i>BMP2</i> was associated with caries experience in primary dentition during logistic regression analysis (p = 0.023; OR = 2.58; 95% CI 1.13-5.86). There was no association between genotype and allele distribution for <i>BMP</i> polymorphisms and primary enamel microhardness alterations. Our result suggests that <i>BMP2</i> may be involved in caries experience in primary dentition from a Nova Friburgo cohort.
Priscila FALAGAN-LOTSCH, Talíria Silva LOPES, Erika Calvano KÜCHLER, Patrícia Nivoloni TANNURE, Marcelo de Castro COSTA, Lidia Maria da Fonte de AMORIM, and José Mauro GRANJEIRO
FapUNIFESP (SciELO)
Nonsyndromic oral clefts are considered a problem of public health in Brazil, presenting a multifactorial etiology that involves genetic and environmental components, such as maternal alcohol consumption. Several candidate genes have been investigated to identify some association with nonsyndromic clefts risk. The epidermal growth factor (EGF) gene is implicated in the normal craniofacial development and its functional +61 A>G polymorphism has been related to cancer susceptibility. It has been suggested that cancer and oral clefts may share the same molecular pathways. Objective Our goal was to evaluate the association between the EGF+61 A>G polymorphism and nonsyndromic oral clefts susceptibility. Material and Methods The case-control study included 218 cleft cases and 253 controls from Brazil. The control group was comprised of individuals without congenital malformations, dental anomalies and family history of clefts. The cleft phenotypes and subphenotypes were determined based on clinical examination. Genomic DNA was extracted from oral mucosa cells obtained by mouthwash. The EGF+61 A>G polymorphism genotype was determined by polymerase chain reaction-restriction fragment length polymorphism. Results We noticed the association between maternal alcohol consumption during pregnancy and cleft occurrence. The A allele and AA genotype were over-represented in cleft cases compared with control group when we considered the bilateral cleft lip with or without cleft palate (CL±P) cases, cleft cases with tooth agenesis and cleft cases presenting family history of cleft, but the differences were not statistically significant. Contradictorily, the G allele was higher in cleft palate only (CP) cases than in control group, showing a borderline p value. Comparing the different cleft phenotypes, we observed statistical differences between CP and CL±P cases. Our data suggest the EGF+61 A>G polymorphism was not related with nonsyndromic oral clefts susceptibility in a Brazilian population, but supported the different genetic background between CL±P and CP. Moreover, we confirmed the potential effect of maternal alcohol intake on cleft risk in our population.
PN Tannure, GG Moraes, MCU Borba, A Abrahão, MTRC Andrade, and TKS Fidalgo
MRE Press
The aim of this case report is to describe the treatment planning of a young child with severe early childhood caries (S-ECC) as well as the prosthetic rehabilitation technique. A 3-year-old female child was referred to the pediatric dentistry clinic with the chief complaint of tooth pain, difficulty in eating and recurrent hospitalizations caused by dental infections. The mother reported intermittent episodes of fever and recurrent swelling of child's face. The girl presented angular cheilitis and was referred to a dietitian. The treatment plain consisted on a behavior changes in oral hygiene habits, exodontias of all primary teeth and oral rehabilitation with a prosthesis. The extracted teeth with periapical lesions were submitted to histopathologic analysis (hematoxilin and eosin staining) and revealed an inflammatory infiltrate. The aesthetic requirement of children with S-ECC has been a challenge to pediatric dentists. In the present case, the oral rehabilitation provided for the children better aesthetic, nutrition, phonation, and functional conditions.
Leonardo Santos Antunes, Patricia Nivoloni Tannure, Lívia Azeredo Alves Antunes, Maria Fernanda Reis, Marcelo Castro Costa, Cresus Vinicius Depes Gouvêa, Beni Olej, and Jose Mauro Granjeiro
Jaypee Brothers Medical Publishing
ABSTRACTAimTo evaluate the association of the polymorphisms in the TGFB3 gene (rs2268626), and the BMP4 gene (rs17563) with dental caries in two different groups (noncleft group and oral cleft group) from a cleft center located at Rio de Janeiro, Brazil.Materials and methodsA total of 486 unrelated children and adolescents with or without caries were evaluated using a cohort design. Data on oral health habits was obtained through a questionnaire and caries data was collected by clinical examination. Genotyping of the selected polymorphisms for TGFB3 and BMP4 were carried out by real-time PCR using the TaqMan assay method from a genomic DNA isolated from buccal epithelial cells of all children and adolescents.ResultsNo association was found between BMP4 polymorphism and caries among individuals from both groups. For TGFB3 polymorphism, significant differences were observed for allele and genotype frequencies between caries free and caries affected individuals in oral cleft group (p = 0.013 and 0.006 for allele and genotype frequencies respectively).ConclusionOur findings provide evidence suggesting that TGFB3 may be involved in caries susceptibility in oral cleft group.Clinical significanceIn the future, the possibility of identifying genes related to caries susceptibility can lead to counseling of the individual that carries gene alterations, with the aim of working on preventive measures for caries as well as bioengineering treatments.How to cite this articleAntunes LS, Tannure PN, Antunes LAA, Reis MF, Costa MC, Gouvêa CVD, Olej B, Granjeiro JM, Küchler EC. Genetic Association for Caries Susceptibility among Cleft Lip and/or Palate Individuals. J Contemp Dent Pract 2014;15(3):288-293.
Cristiana Aroeira Guimarães Rosa Oliveira, Patricia Nivoloni Tannure, Ivete Pomarico Ribeiro de Souza, Lucianne Cople Maia, Maristela Barbosa Portela, and Gloria Fernanda B. de A. Castro
Informa UK Limited
Abstract Objective. To undertake a systematic review to assess if HIV-infected children and adolescents have an increased dental caries experience. Methods. A search of MEDLINE, BIREME, EMBASE, GOOGLE SCHOLAR, SIGLE (Grey Literature) and reference lists of included studies was carried out. To be eligible the studies had to present HIV-infected and non-infected children/adolescents between 0–18 years old. To assess the methodological quality, the studies were categorized in scores from ‘A’ to ‘C’. To perform a meta-analysis a random effect model was used with 95% confidence intervals and two distinct sub-group analyses were carried out in terms of caries progression: data for cavitated and non-cavitated lesions (sub-group 1) and data only for cavitated lesions (sub-group 2). Results. Five studies fulfilled the selection criteria. Four studies (two ranked A and two B in the quality assessment) revealed higher caries scores in primary teeth in the HIV-infected patients with mean dmft/dmfs scores of 3.8–4.1/7.8–11.0 compared to the control group 1.5–2.4/3.4–5.1. No differences in caries index were found for permanent dentition. The meta-analysis excluded caries data of permanent teeth and showed a significant association between caries experience in primary dentition and HIV infection considering cavitated and non-cavitated lesions (OR = 2.33, 95% CI = 1.48–3.68) or only cavitated lesions (OR = 2.98, 95% CI = 1.59–5.59). Conclusion. Evidence exists that suggests HIV-infected children/adolescents have an increased caries experience in primary dentition.
Ticiana M. Sabóia, Maria Fernanda Reis, Ângela M.C. Martins, Helena F. Romanos, Patricia N. Tannure, José Mauro Granjeiro, Alexandre R. Vieira, Leonardo S. Antunes, Erika C. Küchler, and Marcelo C. Costa
Elsevier BV
Erika C. Küchler, Ticiana M. Sabóia, Thays C. Vieira, Andrea Lips, Patricia N. Tannure, Kathleen Deeley, Maria F. Reis, Bao Ho, Ana C. Rey, Marcelo C. Costa,et al.
Informa UK Limited
Abstract Objective. Previous studies suggest individuals born with oral clefts and their families have a higher susceptibility for cancer, which raises the hypothesis that these two conditions share common molecular pathways. This study evaluated the association between oral clefts and polymorphisms in genes that play a role in craniofacial and tumor development. Materials and methods. Four hundred and ninety-seven subjects born with oral clefts and 823 unaffected subjects were recruited. Twenty-nine markers in 13 genes were genotyped by the Taqman method. Chi-square was used to compare allele and genotype frequencies. Bonferroni correction for multiple testing was used and the established alpha was 0.0003. This study also used logistic regression to test if genetic variants were associated with oral clefts using positive family history of cancer and age as covariates. Results. There was no association between family history of cancer and oral clefts (p = 0.51). None of the 1320 study participants had a diagnosis of cancer at the time of participation in the study. The marker rs4980700 in FGF3 was associated with oral clefts (p = 0.0002). Logistic regression analysis also provided evidence for gene–gene interaction between FGF3 (rs4980700) and PAX9 (rs2073242), increasing the risk for isolated oral clefts (p = 0.0003). Conclusion. FGF3 is associated with oral clefts and may interact with PAX9.
Megan L Weber, Hong-Yuan Hsin, Ersan Kalay, Dana Š Brožková, Takehiko Shimizu, Merve Bayram, Kathleen Deeley, Erika C Küchler, Jessalyn Forella, Timothy D Ruff,et al.
Springer Science and Business Media LLC
FALDL Trindade, AR Valente, MRTC Andrade, PN Tannure, AG Antonio, and TKS Fidalgo
APESB (Associacao de Apoio a Pesquisa em Saude Bucal)
Objetivo: Avaliar e comparar o conhecimento de pais e responsaveis de criancas em idade escolar sobre cuidados de higiene bucal e dieta entre uma populacao de criancas de um abrigo e o de uma instituicao de ensino superior. Metodologia: Foi realizado um estudo descritivo transversal, cuja amostra foi composta de 82 responsaveis por criancas em idade escolar do Abrigo Teresa de Jesus (ATJ; n = 47) e da Universidade Veiga de Almeida (UVA; n = 35). O instrumento de coleta de dados foi um questionario com 18 perguntas fechadas sobre higiene e dieta. Apos a aplicacao do questionario, os dados foram tabulados, armazenados em um banco de dados e analisados utilizando o programa SPSS 20.0 (SPSS Inc, Il, EUA). Foi realizada analise descritiva dos dados e avaliacao da normalidade por meio to teste de Shapiro-Wilk (p < 0,05). As variaveis categoricas foram comparadas utilizando o teste χ2 com intervalo de confianca de 95%. Resultados: A media de idade das criancas do ATJ foi de 4,9 (± 2,5) e as da UVA, de 7,1 (± 2,7) (p < 0,01). Nao houve diferenca entre os grupos quanto a idade dos responsaveis (p = 0,71) e grau de instrucao (p = 0,93), no entanto, os responsaveis da UVA apresentaram renda superior aos do ATJ (p = 0,02).Os responsaveis do ATJ possuiam mais informacoes sobre os cuidados com os dentes comparados com os da UVA (p < 0,01). Grande parte do grupo do ATJ (98,7%) alegou que visitar ao dentista tambem e um importante fator para a prevencao de doencas bucais comparado com o grupo da UVA (25,7) (p < 0,01), o que se traduziu em maior numero real de visitas ao dentista (p = 0,03). Foi observado maior conhecimento sobre “dentes tortos” (p < 0,01) e aftas (p = 0,04) pelos responsaveis das criancas do ATJ. Eles tambem associam mais as bacterias (p < 0,01) e nao ir ao dentista como fatores causais da carie (p = 0,03). Conclusao: Apesar de piores condicoes socio-economicas, os responsaveis pelas criancas do ATJ apresentaram mais conhecimentos sobre higiene bucal e dieta que os entrevistados da UVA. E provavel que as atividades educacionais do abrigo tenham influenciado esse resultado.
Erika C. Küchler, Ping Feng, Kathleen Deeley, Carly A. Fitzgerald, Chelsea Meyer, Anastasia Gorbunov, Mariana Bezamat, Maria Fernanda Reis, Jacqueline Noel, M. Zahir Kouzbari,et al.
Elsevier BV
A. R. Vieira, R. N. D’Souza, G. Mues, K. Deeley, H. -Y. Hsin, E. C. Küchler, R. Meira, A. Patir, P. N. Tannure, A. Lips,et al.
Springer Science and Business Media LLC