Development and characterization of electrospun curcumin-loaded PVA/gelatin based nanofibers scaffolds for skin tissue engineering Kritika Sahani, Soumya Shuvra Smita, Sovan Dey, Amit Biswas Journal of Bioactive and Compatible Polymers, 2025 Chronic skin wounds have a profound impact on the global population, affecting over 40 million individuals and resulting in healthcare expenditures exceeding $20 billion annually by 2025. Researchers have developed wound dressings using biocompatible polymers that possess bioactive properties to combat this pressing issue. The present research focuses on fabricating a nanofiber-based composite structure made of Polyvinyl alcohol (PVA) and Gelatin, incorporating varying concentrations of curcumin (0.25, 0.5, and 0.75 mg/ml). The fabrication process employed electrospinning techniques to create nanofiber-based scaffolds that closely mimic the native structure of the extracellular matrix (ECM) found in the skin. The developed nanofiber mats underwent comprehensive characterization through a sequence of in-vitro experiments, encompassing SEM imaging, Fourier transform infrared spectroscopy (FTIR), in-vitro release studies, and evaluation of tensile strength, swelling, and degradation. SEM images revealed a notable reduction in the mean fiber diameter, swelling potential and extent of degradation following the addition of curcumin. Regarding drug release, curcumin demonstrated a biphasic release profile in phosphate buffer (pH 7.4) and Tween 80 solutions. The PVA/gelatin (PG) mats containing curcumin displayed strong antimicrobial effects against Gram-negative E. coli and Gram-positive S. aureus. The biocompatibility of the membranes was further confirmed through cytocompatibility testing utilizing the L929 cell line. Overall, this research indicates that wound dressings made from nanofibers composed of polyvinyl alcohol (PVA) and gelatin, incorporating curcumin, exhibit considerable potential for treating cutaneous wounds. However, additional research is necessary to determine the effectiveness of these dressings in vivo.
Development of Sodium Alginate-Titanium Dioxide Composite Coating on AZ31B Magnesium Alloy to Improve Corrosion Resistance A Singh, A Biswas Materials Today Communications, 114108 , 2025 2025 Citations: 1
Surface characteristics and biological evaluation of TiO2 nanotubes fabricated on Ti6Al4V implant surface KAK Raju, A Biswas Vacuum, 114742 , 2025 2025 Citations: 1
Development of Cu-loaded Chitosan-Coated TiO2 Nanotubular Surfaces for Improved Antibacterial and Biological Functionality KAK Raju, A Biswas Journal of Alloys and Compounds Communications, 100119 , 2025 2025 Citations: 1
Surface modifications and coatings to improve osseointegration and antimicrobial activity on titanium surfaces: a statistical review over the last decade KAK Raju, A Biswas Journal of Orthopaedics 67, 68-87 , 2025 2025 Citations: 28
Structural and biological characterization of high silica bioglass-chitosan composite coating on Ti6Al4V alloy A Jha, S Padhihary, A Biswas Materials Chemistry and Physics 340, 130714 , 2025 2025 Citations: 6
Biological and antibacterial evaluation of Ag-loaded chitosan-coated TiO2 nanotubular surface on Ti6Al4V implants KAK Raju, A Biswas Journal of Industrial and Engineering Chemistry , 2025 2025 Citations: 3
Development and characterization of electrospun curcumin-loaded PVA/gelatin based nanofibers scaffolds for skin tissue engineering K Sahani, SS Smita, S Dey, A Biswas Journal of Bioactive and Compatible Polymers 40 (2), 193-212 , 2025 2025 Citations: 7
Development of Gelatin-Silk Fibroin Hydrogel Incorporated with Strontium-Doped Bioglass for Bone Tissue Regeneration S Biswas, A Biswas 2025
Strontium doped 58S bioglass incorporated chitosan/gelatin porous scaffold for bone tissue engineering applications AK Singh, A Biswas International journal of biological macromolecules 283, 136983 , 2024 2024 Citations: 10
Development of Quercetin-loaded polyvinyl-alcohol/gelatin nanofibrous coating over Ti–6Al–4V bone implant with improved antibacterial and bioactive characteristics S Dey, AK Singh, SS Smita, A Biswas, S Kumar Journal of Materials Science 59 (26), 11799-11816 , 2024 2024 Citations: 11
Structural and corrosion analysis of copper/chitosan coating on nanotubular TiO2/Ti6Al4V implant surface KAK Raju, A Biswas Surface and Coatings Technology 482, 130673 , 2024 2024 Citations: 18
Evaluation of structural and corrosion behavior of chitosan/silver coating on Ti6Al4V/TiO2 nanotubular surface KAK Raju, A Biswas Surface and Coatings Technology 476, 130262 , 2024 2024 Citations: 14
Enhanced corrosion resistance of 58S bioglass integrated TiO2 nanotubular arrays KAK Raju, A Biswas, AK Singh, Y Mahton, P Saha Next Nanotechnology 6, 100070 , 2024 2024 Citations: 7
Constructing a biofunctionalized 3D-printed gelatin/sodium alginate/chitosan tri-polymer complex scaffold with improvised biological and mechanical properties for bone-tissue … AK Singh, K Pramanik, A Biswas Bio-Design and Manufacturing 7 (1), 57-73 , 2024 2024 Citations: 37
Corrosion behavior of self-organized TiO2 nanotubular arrays grown on Ti6Al4V for biomedical applications KAK Raju, A Biswas Materials Chemistry and Physics 305, 128011 , 2023 2023 Citations: 24
Design of magnesium oxide nanoparticle incorporated carboxy methyl cellulose/poly vinyl alcohol composite film with novel composition for skin tissue engineering N Verma, K Pramanik, AK Singh, A Biswas Materials Technology 37 (8), 706-716 , 2022 2022 Citations: 71
A Comprehensive Review of Adaptive Antibacterial Coatings for Implants, Metallic and Herbal Coating Materials and Implant Biomaterial Characterization KAK Raju, A Biswas Asian Conference on Indoor Environmental Quality, 17-48 , 2021 2021 Citations: 3
Antibacterial activity and biocompatibility of curcumin/TiO 2 nanotube array system on Ti6Al4V bone implants S Saha, K Pramanik, A Biswas Materials Technology 36 (4), 221-232 , 2021 2021 Citations: 31
Psychological Impact of Medical Professionals Handling COVID-19 Patients in Hospitals A Biswas, S Biswas, A Bhowmik J Toxicol Risk Assess 6, 034 , 2020 2020
Effect of SiC content on mechanical and tribological properties of Al2024-SiC composites. Silicon 14: 1–11 D Dey, A Bhowmik, A Biswas 2020 Citations: 7
MOST CITED SCHOLAR PUBLICATIONS
Surface characterization and mechanical property evaluation of thermally oxidized Ti-6Al-4V A Biswas, JD Majumdar Materials Characterization 60 (6), 513-518 , 2009 2009 Citations: 115
Optimization and evaluation of silk fibroin-chitosan freeze-dried porous scaffolds for cartilage tissue engineering application V Vishwanath, K Pramanik, A Biswas Journal of Biomaterials science, Polymer edition 27 (7), 657-674 , 2016 2016 Citations: 107
Laser Surface Nitriding of Ti-6Al-4V for Bio-implant Application LLJDM A. Biswas, T. K. Maity, U. K. Chatterjee, I. Manna Trends in Biomaterials & Artificial Organs 20, 68-72 , 2006 2006 Citations: 74
Design of magnesium oxide nanoparticle incorporated carboxy methyl cellulose/poly vinyl alcohol composite film with novel composition for skin tissue engineering N Verma, K Pramanik, AK Singh, A Biswas Materials Technology 37 (8), 706-716 , 2022 2022 Citations: 71
Studies on thermal oxidation of Mg-alloy (AZ91) for improving corrosion and wear resistance JD Majumdar, U Bhattacharyya, A Biswas, I Manna Surface and Coatings Technology 202 (15), 3638-3642 , 2008 2008 Citations: 69
MgO enables enhanced bioactivity and antimicrobial activity of nano bioglass for bone tissue engineering application AK Singh, K Pramanik, A Biswas Materials Technology 34 (13), 818-826 , 2019 2019 Citations: 58
Mechanical and electrochemical properties of laser surface nitrided Ti–6Al–4V A Biswas, L Li, UK Chatterjee, I Manna, SK Pabi, JD Majumdar Scripta Materialia 59 (2), 239-242 , 2008 2008 Citations: 57
Silk fibroin coated TiO2 nanotubes for improved osteogenic property of Ti6Al4V bone implants S Saha, K Pramanik, A Biswas Materials Science and Engineering: C 105, 109982 , 2019 2019 Citations: 53
Development of novel electrospun nanofibrous scaffold from P. ricini and A. mylitta silk fibroin blend with improved surface and biological properties N Panda, A Bissoyi, K Pramanik, A Biswas Materials Science and Engineering: C 48, 521-532 , 2015 2015 Citations: 52
Interaction of osteoblast-TiO2 nanotubes in vitro: the combinatorial effect of surface topography and other physico-chemical factors governs the cell fate S Saha, R Kumar, K Pramanik, A Biswas Applied Surface Science 449, 152-165 , 2018 2018 Citations: 47
In vitro cartilage construct generation from silk fibroin‐ chitosan porous scaffold and umbilical cord blood derived human mesenchymal stem cells in dynamic … P Agrawal, K Pramanik, A Biswas, R Ku Patra Journal of Biomedical Materials Research Part A 106 (2), 397-407 , 2018 2018 Citations: 47
Diode laser assisted surface nitriding of Ti-6Al-4V: properties of the nitrided surface A Biswas, L Li, UK Chatterjee, I Manna, JD Majumdar Metallurgical and Materials Transactions A 40 (12), 3031-3037 , 2009 2009 Citations: 40
Enhanced chondrogenesis of mesenchymal stem cells over silk fibroin/chitosan‐chondroitin sulfate three dimensional scaffold in dynamic culture condition P Agrawal, K Pramanik, V Vishwanath, A Biswas, A Bissoyi, PK Patra Journal of Biomedical Materials Research Part B: Applied Biomaterials 106 (7 … , 2018 2018 Citations: 38
Constructing a biofunctionalized 3D-printed gelatin/sodium alginate/chitosan tri-polymer complex scaffold with improvised biological and mechanical properties for bone-tissue … AK Singh, K Pramanik, A Biswas Bio-Design and Manufacturing 7 (1), 57-73 , 2024 2024 Citations: 37
Enhanced osteogenic potential of human mesenchymal stem cells on electrospun nanofibrous scaffolds prepared from eri‐tasar silk fibroin NN Panda, A Biswas, K Pramanik, S Jonnalagadda Journal of Biomedical Materials Research Part B: Applied Biomaterials 103 (5 … , 2015 2015 Citations: 34
Antibacterial activity and biocompatibility of curcumin/TiO 2 nanotube array system on Ti6Al4V bone implants S Saha, K Pramanik, A Biswas Materials Technology 36 (4), 221-232 , 2021 2021 Citations: 31
Development of a novel glucosamine/silk fibroin–chitosan blend porous scaffold for cartilage tissue engineering applications V Vishwanath, K Pramanik, A Biswas Iranian Polymer Journal 26 (1), 11-19 , 2017 2017 Citations: 31
Chondrogenic differentiation of mesenchymal stem cells on silk fibroin: chitosan–glucosamine scaffold in dynamic culture P Agrawal, K Pramanik, A Biswas Regenerative medicine 13 (5), 545-558 , 2018 2018 Citations: 30
Directing osteogenesis of stem cells with hydroxyapatite precipitated electrospun eri–tasar silk fibroin nanofibrous scaffold N Panda, A Bissoyi, K Pramanik, A Biswas Journal of Biomaterials Science, Polymer Edition 25 (13), 1440-1457 , 2014 2014 Citations: 29
Surface modifications and coatings to improve osseointegration and antimicrobial activity on titanium surfaces: a statistical review over the last decade KAK Raju, A Biswas Journal of Orthopaedics 67, 68-87 , 2025 2025 Citations: 28