Nanomaterials: Potential Broad Spectrum Antimicrobial Agents Prabhurajeshwar Chidre, Ashajyothi Chavan, Navya Hulikunte Mallikarjunaiah, Kelmani Chandrakanth Revanasiddappa Natural Product Communications, 2023 Nanotechnology is a promising science with new aspects to fight and prevent various diseases using nanomaterials. The capability to expose the structure and functions of biosystems at the nanoscale level supports research leading to development in biology, biotechnology, medicine, and healthcare. This is predominantly advantageous in treating microbial infections as an alternative to antibiotics. However, widespread production, use, and misuse of antibiotics have input to the next-generation alarm for the emergence of multiple-drug-resistant pathogenic bacteria. Due to infectious diseases from these drug-resistant pathogenic strains, human mortality rates have consistently increased and are becoming an epidemic in our society. Consequently, there is a strong demand for developing novel strategies and new materials that can cope with these problems. The emergence of nanotechnology has created many new antimicrobial options. The small size of these nanomaterials is suitable for carrying out biological operations. Several metals and metal oxides, such as silver, copper, gold, zinc oxide, and iron oxide nanoparticle types have shown toxicity toward several pathogenic microbes. Metal-based nanoparticles have been broadly examined for a set of biomedical applications. According to the World Health Organization, the reduced size and selectivity of metal-based nanoparticles for bacteria have established them to be effective against pathogens causing concern. Metal-based nanoparticles are known to have nonspecific bacterial toxicity mechanisms, which not only make the development of resistance by bacteria difficult, but also widen the spectrum of antibacterial activity. Metal-based nanoparticle efficiency studies achieved so far have revealed promising results against both Gram-positive and Gram-negative bacteria. Here we discuss the potential nanomaterials to either treat microbial resistance or induce development of resistance. However, fundamental research is required to focus on the molecular mechanism causing the antimicrobial activity of nanomaterials.
Nanomaterials: Potential Broad Spectrum Antimicrobial Agents Prabhurajeshwar Chidre, Ashajyothi Chavan, Navya Hulikunte Mallikarjunaiah, Kelmani Chandrakanth Revanasiddappa Current Nanomaterials, 2023 Nanotechnology is a promising science with new aspects to fight and prevent various diseases using nanomaterials. The capability to expose the structure and functions of biosystems at the nanoscale level supports research leading to development in biology, biotechnology, medicine and healthcare. This is predominantly advantageous in treating microbial infections as an alternative to antibiotics. However, widespread production, and use and misuse of antibiotics have led to the emergence of multiple-drug resistant (MDR) pathogenic bacteria. Due to infectious diseases from these drug-resistant pathogenic strains, human mortality rates have consistently increased and are becoming an epidemic in our society. Consequently, there is a strong demand for developing novel strategies and new materials that can cope with these problems. The emergence of nanotechnology has created many new antimicrobial options. The small size of these nanomaterials is suitable for carrying out biological operations. Several metals and metal oxides, such as silver, copper, gold, zinc oxide and iron oxide nanoparticle types, have shown toxicity toward several pathogenic microbes. Metal-based nanoparticles have been broadly examined for a set of biomedical applications. According to the World Health Organization, the reduced size and selectivity of metal-based nanoparticles for bacteria have established them to be effective against pathogens, causing concern. Metal-based nanoparticles are known to have non-specific bacterial toxicity mechanisms, which not only make the development of resistance by bacteria difficult, but also widen the spectrum of antibacterial activity. Metal-based nanoparticle efficiency studies achieved so far have revealed promising results against both Gram-positive and Gram-negative bacteria. Here we discuss the potential nanomaterials to either treat microbial resistance or induce the development of resistance. However, fundamental research is required to focus on the molecular mechanism causing the antimicrobial activity of nanomaterials.
Cytotoxicity and genotoxicity of metal oxide nanoparticles in human pluripotent stem cell-derived fibroblasts Harish K Handral, C. Ashajyothi, Gopu Sriram, Chandrakanth R. Kelmani, Nileshkumar Dubey, et al. Coatings, 2021 Advances in the use of nanoparticles (NPs) has created promising progress in biotechnology and consumer-care based industry. This has created an increasing need for testing their safety and toxicity profiles. Hence, efforts to understand the cellular responses towards nanomaterials are needed. However, current methods using animal and cancer-derived cell lines raise questions on physiological relevance. In this aspect, in the current study, we investigated the use of pluripotent human embryonic stem cell- (hESCs) derived fibroblasts (hESC-Fib) as a closer representative of the in vivo response as well as to encourage the 3Rs (replacement, reduction and refinement) concept for evaluating the cytotoxic and genotoxic effects of zinc oxide (ZnO), titanium dioxide (TiO2) and silicon-dioxide (SiO2) NPs. Cytotoxicity assays demonstrated that the adverse effects of respective NPs were observed in hESC-Fib beyond concentrations of 200 µg/mL (SiO2 NPs), 30 µg/mL (TiO2 NPs) and 20 µg/mL (ZnO NPs). Flow cytometry results correlated with increased apoptosis upon increase in NP concentration. Subsequently, scratch wound assays showed ZnO (10 µg/mL) and TiO2 (20 µg/mL) NPs inhibit the rate of wound coverage. DNA damage assays confirmed TiO2 and ZnO NPs are genotoxic. In summary, hESC-Fib could be used as an alternative platform to understand toxicity profiles of metal oxide NPs.
A pilot toxicology study of biogenic silver nanoparticles: in vivo by intraperitoneal and intravenous infusion routes in rats C. Ashajyothi, R. Kelmani Chandrakanth Journal of Experimental Nanoscience, 2019 Toxic effects of nanoparticles on human health are considerably increasing their worldwide recognition. Currently silver nanoparticles are being widely used in consumer medical products, due to its uniqueness in biomedical applications. Uptake of these particles via various administration routes can also lead to different toxic effects. In this study, we assessed the toxic effect of 11–75 nm ranged biogenic silver nanoparticles (Bio-AgNPs) on male wistar rats by using two different administration routes namely, intraperitoneal and intravenous routes. The three different concentrations, No Observable Adverse Effect Concentration (NOAEC), Inhibitory concentration (IC50) and Total lethal concentration (TLC) was appraised at the dose range of 97.64 to 132 µg/kg for both i/p and i/v routes. There is no considerable changes in hematological parameters in i/p and i/v routes on 14th and 28th day of observation, but the increase was trivial significant for platelet count at the dose of 97–105 µg/kg (IC50) for i/p route of injection. There is no remarkable adverse impact on liver, spleen and kidney were observed in IC50 and TLC treated group, when determined by biochemical and histopathological analysis both in i/p and i/v routes treated rats. This estimation confirms that, Bio-AgNPs are not going effect the human metabolic system.
Antioxidant activity of Alstonia scholarsis extracts containing flavonoid and phenolic compounds International Journal of Pharmacy and Pharmaceutical Sciences, 2012
RECENT SCHOLAR PUBLICATIONS
Molecular Dynamics Based Comparative Analysis of Native Urtica dioica Agglutinin and Its Engineered Mutant UDAM5 MJ Gurav, PH Megalamani, NP Dalbanjan, SKP Kumar, VB Chachadi In Silico Research in Biomedicine, 100303 , 2026 2026
Plastics: an overview of applications, potential health risk, carcinogen to restriction MJ Gurav, PH Megalamani, NP Dalbanjan, AS Sanji, AK Oli, SKP Kumar, ... Next Research, 101512 , 2026 2026
Next generation sustainable nanostructures for energy, sensing, and bio-integration K Korgaonkar, NP Dalbanjan, S Sharma, R Jadhav, SK Praveenkumar, ... Nano-Structures & Nano-Objects 45, 101615 , 2026 2026 Citations: 1
A Comprehensive Review of Carbohydrate Polymer Hydrocolloids: Structure, Function, and Applications in Food Systems MP Eelager, NP Dalbanjan, B Dewangan, M Madar, DS Abraham, ... Food Reviews International, 1-40 , 2026 2026 Citations: 1
Fabrication of gallic acid crosslinked chitosan/poly (1-vinylpyrrolidone-co-vinyl acetate) antioxidant films for green chilli packaging BA Sheeparamatti, P Baburao, SG Havanur, RB Chougale, MN Gunaki, ... RSC Applied Polymers 4 (2), 767-784 , 2026 2026 Citations: 3
Tradescantia pallida extract incorporated chitosan/pullulan intelligent biodegradable films: an eco-friendly packaging to preserve the freshness of chicken MP Eelager, SP Masti, S Madihalli, RB Chougale, NP Dalbanjan, ... Sustainable Food Technology , 2026 2026 Citations: 5
Electrochemical techniques in protein engineering: Innovations in redox-active protein design and electron transfer mechanisms NP Dalbanjan, K Korgaonkar, AJ Kadapure, MJ Gurav, VB Chachadi, ... International Journal of Biological Macromolecules, 149750 , 2025 2025 Citations: 5
Epidemiology, antimicrobial resistance, economic burden, and management approaches for staphylococcus aureus-associated bovine mastitis: a systematic review BN Gonal, NP Dalbanjan, AJ Kadapure, SKP Kumar, SB Arakera Animals and Zoonoses , 2025 2025 Citations: 3
Molecular Interactions and Pharmacological Evaluation of Quinoline-Imidazole Derivatives: an In Vitro and In Silico Approach NP Dalbanjan, L Bheemayya, AJ Kadapure, MP Eelager, RR Kamble, ... Russian Journal of Bioorganic Chemistry 51 (6), 2531-2548 , 2025 2025 Citations: 1
Pathways to a sustainable future: Exploring the synergy between sustainability and circular economy MP Eelager, NP Dalbanjan, S Madihalli, M Madar, NP Agadi, ... Sustainable Futures 10, 101208 , 2025 2025 Citations: 41
Synthesis and characterization of coumarin derivatives for chemosensor application via experimental and theoretical approaches M Madar, V Srinivasan, MP Eelager, NP Dalbanjan, KN Kummur, V Nayak, ... Tetrahedron 185, 134796 , 2025 2025 Citations: 6
Integrating synthetic biology and biosensing: Current trends and future prospects K Korgaonkar, NP Dalbanjan, MJ Gurav, MP Eelager, VB Chachadi, ... Next Research, 100911 , 2025 2025 Citations: 4
Biosynthesis of Silver Nanoparticles Using Martynia Annua Leaf Extract Chitosan-Pullulan Bio-Nanocomposite Films for Packaging Applications OJ Priyadarshi, D’souza, JP Pinto, VD Hiremani, SP Masti, NP Dalbanjan, ... Food and Humanity 5, 100840 , 2025 2025 Citations: 3
Bacterial peptide antibiotics: A comprehensive review on biosynthesis, mechanisms, and therapeutic potential NP Dalbanjan, K Korgaonkar, R Parvatkar, S Tilvi Next Research, 100850 , 2025 2025 Citations: 4
Ultrasonication driven, ionic liquid catalyzed synthesis of new benzo [d] isoxazole Schiff base derivatives: A comprehensive study of computational investigation, molecular … S Kurahatti, RG Kalkhambkar, M Rathod, R Kapavarapu, K Sindogi, ... Journal of Molecular Liquids 434, 127964 , 2025 2025 Citations: 6
Evaluation of in vitro and in silico antihyperglycemic, antioxidant, anti-inflammatory potencies of selected quinoline-imidazole hybrids NP Dalbanjan, L Bheemayya, AJ Kadapure, BK Kiran, RR Kamble, ... Discover Chemistry 2 (1), 204 , 2025 2025 Citations: 10
Catalyst to Cure: A Multifunctional Cu 2 O Nanoparticle Catalyst Synthesized using Muntingia Calabura Fruit Extract MR Nayak, RR Kamble, B Kodasi, P Hegde, S Naik, T Reddy, S Swadi, ... ChemistrySelect 10 (29), e02440 , 2025 2025 Citations: 3
Stress Response Proteins Are the Reliant Factors for Resilience in the Soil Bacterium Bacillus haynesii PSK.N4 NP Dalbanjan, AJ Kadapure, SKP Kumar Microbiology 94 (4), 572-586 , 2025 2025 Citations: 5
Stress-induced proteins enhance thermal endurance in soil bacterium Priestia aryabhattai strain PSK.N2 NP Dalbanjan, AJ Kadapure, SK Praveen Kumar Antonie Van Leeuwenhoek 118 (8), 102 , 2025 2025 Citations: 5
Exploring the Molecular Interaction between Bovine Serum Albumin and the Antiviral Drug Valacyclovir Using Multispectral Approaches and Molecular Docking Studies NM Gokavi, JI Gowda, NP Dalbanjand, AM Bagoji, ST Nandibewoor, ... Chemical Data Collections, 101198 , 2025 2025 Citations: 3
MOST CITED SCHOLAR PUBLICATIONS
Descriptive review on conversion of waste residues into valuable bionanocomposites for a circular bioeconomy NP Dalbanjan, MP Eelager, K Korgaonkar, BN Gonal, AJ Kadapure, ... Nano-Structures & Nano-Objects 39, 101265 , 2024 2024 Citations: 115
Evaluation of mechanical, antimicrobial, and antioxidant properties of vanillic acid induced chitosan/poly (vinyl alcohol) active films to prolong the shelf life of green chilli MP Eelager, SP Masti, RB Chougale, VD Hiremani, SS Narasgoudar, ... International Journal of Biological Macromolecules 232, 123499 , 2023 2023 Citations: 94
Microbial protein sources: A comprehensive review on the potential usage of fungi and cyanobacteria in sustainable food systems NP Dalbanjan, MP Eelager, SS Narasagoudr Food and Humanity 3, 100366 , 2024 2024 Citations: 63
Chitosan, Poly (vinyl alcohol) and Chitosan/Poly (vinyl alcohol) based active films loaded with white turmeric powder for food packaging applications VG Bhat, SP Masti, SS Narasagoudr, RB Chougale, PK Sk, NP Dalbanjan, ... Food Bioscience 60, 104402 , 2024 2024 Citations: 52
A Chronicle Review of In-Silico Approaches for Discovering Novel Antimicrobial Agents to Combat Antimicrobial Resistance NP Dalbanjan, PK S. K. Indian Journal of Microbiology 64, 1-15 , 2024 2024 Citations: 51
Noni (Morinda citrifolia) leaf extract incorporated methylcellulose active films: A sustainable strategy for browning inhibition in apple slice packaging MP Eelager, SP Masti, RB Chougale, NP Dalbanjan, SKP Kumar International Journal of Biological Macromolecules 269, 132270 , 2024 2024 Citations: 49
Quinic acid and montmorillonite integrated chitosan/pullulan active films with potent antimicrobial and barrier properties to prolong the shelf life of tofu S Madihalli, SP Masti, MP Eelager, RB Chougale, LK Kurabetta, ... Food Bioscience 62, 105492 , 2024 2024 Citations: 46
A synergistic influence of gallic acid/ZnO NPs to strengthen the multifunctional properties of methylcellulose: A conservative approach for tomato preservation LK Kurabetta, SP Masti, MN Gunaki, AA Hunashyal, MP Eelager, ... International Journal of Biological Macromolecules 277, 134191 , 2024 2024 Citations: 45
Atrazine integrated biodegradable poly (vinyl alcohol)/xanthan gum active films for mulching applications: An alternative to microplastic generation plastic mulch MP Eelager, SP Masti, NP Dalbanjan, S Madihalli, MN Gunaki, ... Progress in Organic Coatings 192, 108510 , 2024 2024 Citations: 43
Pathways to a sustainable future: Exploring the synergy between sustainability and circular economy MP Eelager, NP Dalbanjan, S Madihalli, M Madar, NP Agadi, ... Sustainable Futures 10, 101208 , 2025 2025 Citations: 41
A comprehensive review on latent role of stress proteins in antibiotic resistance NP Dalbanjan, AJ Kadapure, PK SK The Microbe 4, 100151 , 2024 2024 Citations: 40
Functional properties of taro starch reinforced polysaccharide based films for active packaging JP Pinto, OJ D'souza, VD Hiremani, NP Dalbanjan, SKP Kumar, ... Food Bioscience 56, 103340 , 2023 2023 Citations: 40
In-silico strategies in nano-drug design: bridging nanomaterials and pharmacological applications NP Dalbanjan, K Korgaonkar, MP Eelager, BN Gonal, AJ Kadapure, ... Nano TransMed, 100091 , 2025 2025 Citations: 37
Ultrasound-driven facile fabrication of Pd doped SnO2 hierarchical superstructures: Structural, growth mechanism, dermatoglyphics, and anti-cancer activity BRR Krushna, K Manjunatha, SY Wu, D Sivaganesh, SC Sharma, ... Biomaterials Advances, 213855 , 2024 2024 Citations: 36
Sodium alginate/poly (vinyl alcohol) active films incorporated with Chrysanthemum leaves extract as an eco-friendly approach to extend the shelf life of green chilies S Madihalli, SP Masti, MP Eelager, RB Chougale, NP Dalbanjan, ... International journal of biological macromolecules 302, 140926 , 2025 2025 Citations: 35
Influence of chitosan-capped quercetin nanoparticles on chitosan/poly (vinyl) alcohol multifunctional films: A sustainable approach for bread preservation MN Gunaki, SP Masti, LK Kurabetta, JP Pinto, AA Hunashyal, ... International Journal of Biological Macromolecules, 140029 , 2025 2025 Citations: 27
Characterization of heat, salt, acid, alkaline, and antibiotic stress response in soil isolate Bacillus subtilis strain PSK. A2 AJ Kadapure, NP Dalbanjan, PK SK International microbiology: the official journal of the Spanish Society for … , 2024 2024 Citations: 26
Development of novel, green, efficient approach for the synthesis of indazole and its derivatives; insights into their pharmacological and molecular docking studies SB Rayawgol, K Sujatha, NP Dalbanjan, PK SK, SK Rajappa Journal of the Indian Chemical Society, 101178 , 2024 2024 Citations: 26
Exploration of physicochemical and biological properties of phenylalanine incorporated carboxymethyl cellulose/poly (vinyl alcohol) based bioactive films for food packaging … LK Kurabetta, SP Masti, MN Gunaki, AA Hunashyal, RB Chougale, ... Food Bioscience 61, 104869 , 2024 2024 Citations: 25
Assessing the in vitro anti-glycation efficacy of vitamins A, C, D, E NP Dalbanjan, AJ Kadapure, P Huded, VB Chachadi, S Nayaka, ... The Ukrainian Biochemical Journal 94 (4), 61-66 , 2022 2022 Citations: 24
Publications
Dalbanjan N P, Kadapure A J, Huded P, Chachadi V B, Nayaka S, Praveen Kumar S K. Assessing the in vitro anti-glycation efficacy of vitamins A, C, D, E. Ukr Biochem J. 2022; 94(4): 24-29.