Shweta Jain
@smgi.org.in
Associate Professor
Sir Madanlal Institute of Pharmacy
RESEARCH INTERESTS
Plant Extraction and isolation
Scopus Publications
Scholar Citations
Scholar h-index
Scholar i10-index
Scopus Publications
Shweta Jain, Shalini Tripathi, and Pushpendra Kumar Tripathi
Elsevier BV
Shweta Jain, Mudit Kumar, Pushpendra Kumar, Jyoti Verma, Jessica M. Rosenholm, Kuldeep K. Bansal, and Ankur Vaidya
MDPI AG
Lipid nanoparticles (LNPs) are spherical vesicles composed of ionizable lipids that are neutral at physiological pH. Despite their benefits, unmodified LNP drug delivery systems have substantial drawbacks, including a lack of targeted selectivity, a short blood circulation period, and in vivo instability. lipid–polymer hybrid nanoparticles (LPHNPs) are the next generation of nanoparticles, having the combined benefits of polymeric nanoparticles and liposomes. LPHNPs are being prepared from both natural and synthetic polymers with various techniques, including one- or two-step methods, emulsification solvent evaporation (ESE) method, and the nanoprecipitation method. Varieties of LPHNPs, including monolithic hybrid nanoparticles, core–shell nanoparticles, hollow core–shell nanoparticles, biomimetic lipid–polymer hybrid nanoparticles, and polymer-caged liposomes, have been investigated for various drug delivery applications. However, core–shell nanoparticles having a polymeric core surrounded by a highly biocompatible lipid shell are the most commonly explored LPHNPs for the treatment of various diseases. In this review, we will shed light on the composition, methods of preparation, classification, surface functionalization, release mechanism, advantages and disadvantages, patents, and clinical trials of LPHNPs, with an emphasis on core–shell-structured LPHNPs.
Shweta Jain, Shalini Tripathi, and Pushpendra Kumar Tripathi
Medic Scientific
The study was performed to identify the imperative pharmacognostic details of berberis aristata DC roots. The root of the plant was standardized by morphologically and microscopically. Further other parameters chemomicroscopical, physical, hytochemical screening and florescence analysis were performed to determine the diagnostic features of berberis aristata DC (B. aristata). Macro and microscopic studies were also reported in the present study. Physicochemical parameters including extractive values, ash values, moisture content have been calculated, which showed 0.79 total ash, 0.05 acid insoluble ash, 20 water soluble ash and 0.90 water insoluble ash. The extractive values of berberis aristata DC were found to be 3.6, 1.2, 0.6 and 2.3 in ethanol, Pet. ether, acetone, and in water respectively. Phytochemical analysis closely revealed the presence of alkaloids in this plant. These outcomes will further help to standardize, identification and in execution research on this plant.
Shweta Jain and Ankur Vaidya
Elsevier BV
Shweta Jain, Pushpendra Kumar, Mudit Kumar, and Ankur Vaidya
Elsevier
Shweta Jain, Shalini Tripathi, and Pushpendra Kumar Tripathi
Elsevier BV
Ramakant Yadav, Neha Dubey, Shweta Jain, Ankur Vaidya, and Raj Kumar
Bentham Science Publishers Ltd.
Objective: The aim of the present study was to investigate the psychiatric distress, including stress, anxiety, and depression levels, among COVID-19 positive patients who were admitted between 01 July 2020 to 31 August 2020 to the COVID-19 isolation ward of the Uttar Pradesh University of Medical Sciences, Saifai, Etawah India. Participants included 100 patients, with 55 males and 45 females. The majority of admitted patients (81%) were illiterate. Out of 100 patients, 83 were married, 16 were unmarried, and only 1 was a widow. Methods: Levels of anxiety, depression, and stress level were noted in admitted patients using Generalized Anxiety Disorder-7 (GAD-7), Patient Health Questionnaire (PHQ-9) depression assessment, and Perceived Stress Scale 4 (PSS-4) assessment techniques, respectively. Results: Patient Health Questionnaire (PHQ-9) depression assessment results showed minimal, mild, and moderate depression in 9, 25, and 66 patients, respectively, with a 10.6 median score of PHQ-9. Mild, moderate, and severe anxiety (GAD-7 score) was present in 22, 28, and 50 of the patients surveyed. The mean Perceived Stress Scale 4 (PSS-4) was also analyzed, and it reported 6.1 values. The results of the study demonstrated that the patients had a high label of psychiatric distress, but still, admitted patients believe that they will come out from this pandemic condition. Conclusion: Although patients claimed psychiatric distress and mental health illness, they still denied the requirement of any mental health professionals to minimize stress levels and were satisfied with the medical facilities available in a hospital located in a rural area.
Shweta Jain, Ankur Vaidya, Pawan Kumar Gupta, Jessica M. Rosenholm, and Kuldeep K. Bansal
MDPI AG
Numerous plant isolates with therapeutic properties, such as antimicrobial, antiinflammatory, antiviral, antimalarial, antiarthritic (AA), hepatoprotective, cardiotonic, and so forth, are reported in the literature. Usually, medicinal plants are widely used, and assumed to be safe and cheaper alternatives to chemically synthesized drugs. However, they are not regulated for potency and purity, and thus care must be taken for their safe use. In this review, we aimed to compile all of the herbal isolates possessing AA properties, including alkaloids (montanine, 3-acetylaconitine, sanguinarine, jatrorrhizine hydrochloride, and piperine), terpenoids (eugenol, nimbolide, bartogenic acid, cannabidiol, and curcumin), and flavonoids (quercetin, resveratrol, kaempferol, chebulanin, ellagic acid, rosmarinic acid, gallic acid, chlorogenic acid, ferulic acid, and brazilin). These isolates act through numerous pharmacological mechanisms such as inhibiting cytokines, chemokines, or matrix metalloproteinase, etc., to demonstrate AA activity. Animal models utilized for assessing the AA properties of these isolates, including adjuvant-induced arthritis mouse models, are also discussed. Furthermore, nanotechnology-based approaches to deliver these isolates are also reviewed, which have shown improved therapeutic efficacy of isolated compounds.
Poonam Yadav, Ramakant Yadav, Shweta Jain, and Ankur Vaidya
Wiley
Caspases, a group of protease enzymes (cysteine proteases) exist as inactive zymogens in the cells and execute apoptosis (programmed cell death). Caspase-3, an executioner caspase plays an imperative role in apoptosis and becomes a primary target for cancer treatment. A number of analogues of quinazoline, quinazolinone, indoloquinazolines, quinone, naphthoquinones, pyrroloiminoquinones, styrylquinolines, tetheredtetrahydroquinoline, fluoroquinolone, thiosemicarbazones, benzotriazole, pyrimidines, chalcone and carbazoles have been reported till date, representing caspase-3 mediated apoptosis for cancer therapy. Simultaneously, plant isolates, including lysicamine, podophyllotoxin and majoranolide have also been claimed for caspase-3 mediated apoptosis induced cytotoxicity. Procaspase-activating compound-1 (PAC-1) is the first FDA approved orphan drug and its synthetic derivative WF-208 also showed fascinating caspase-3 mediated anticancer activity. Till date large number of compounds have been reported and patented for their capsase-3 mediated cytotoxicity and now scientist is also focusing to introduce new compounds in market to encompass anticancer activity.
Ajay Kumar Shukla
Society of Pharmaceutical Tecnocrats
The present summarized paper on medicinal plants that have been reported by researchers on experimental or clinical anti-diabetic evidence and that have been used in traditional systems of medicine. A diabetes mellitus disease is one of the most frequent non-communicable diseases worldwide. A complete review was conducted to pile up information about anti-diabetic medicinal plants. It is a metabolic disorder disease of the endocrine system and affecting almost 10% of the population all over the world also the number of those affected is increasing day by day. In this review covered the following sections such as anti-diabetic medicinal plant, bioactive molecules, and experimental model. Future perspectives of Anti-diabetic bioactive molecules and are also discussed.
Shweta Jain, Shalini Tripathi, and Pushpendra Kumar Tripathi
Elsevier BV
Shweta Jain, Ankur Vaidya, Nancy Jain, Vimal Kumar, and Anuj Modi
Springer International Publishing
Ramakant Yadav
Society of Pharmaceutical Tecnocrats
With the sudden outbreak of coronavirus disease of 2019 (COVID-19) pandemic, the Health Care Workers (HCWs) have claimed varying echelons of stress, anxiety and insomnia This is the first write up ever reported describing the numerous studies conducted globally to determine the mental health issues in HCWs throughout in COVID-19 pandemic Herein we compile the studies conducted in different countries worldwide All these studies alleged high pervasiveness of stress, anxiety, depression, insomnia, somatization, obsessive-compulsive symptoms and other mental disorders in HCWs Female medical staff showed high occurrence of mental distress over male medical staff Transmission of infection from HCWs to their family members further increases fear and distress Ample education, training, psychosocial services and social support have improve mental health of HCWs © 2021 MEDIC SCIENTIFIC All rights reserved
Ankur Vaidya, Shweta Jain, Anupriya Jain, and Aviral Jain
Springer Science and Business Media LLC
The aim of the present work was to formulate simvastatin-loaded PEGylated solid lipid nanoparticles (PEG-SLNs) for prolonging blood circulation. Plain solid lipid nanoparticles (P-SLNs) were prepared by ethanol injection method. Prepared P-SLNs were PEGylated using carbodiimide chemistry by coupling the amine group of bis-amine PEG with the carboxyl group of the phosphatidylcholine present on the surface of previously formed drug-loaded P-SLNs in the presence of 1-ethyl-3(3-dimethylaminopropyl) carbodiimide (EDC). The success of the pegylation of P-SLNs was confirmed by the IR spectra of P-SLNs and PEG-SLNs. The average particle size and zeta potential for P-SLNs and PEG-SLNs were found to be 322.3 ± 3.71 nm; − 32.7 ± 0.15 and 351.6 ± 1.23 nm; − 10.6 ± 0.79, respectively. DSC curves and XRD pattern confirmed the homogenous dispersion of simvastatin and concluding the presence of simvastatin in an amorphous state in both nanoparticle formulations. A biphasic in vitro drug release pattern was found with both the nanoparticles formulations, P-SLNs shows a drug release of 96.02 ± 2.41% within 48 h, while 91.89 ± 1.72% drug was released from PEG-SLNs within 72 h. PEG-SLNs were found to be less hemolytic toxic as compared to P-SLNs. Prepared PEG-SLNs were found to be long-circulating, with low elimination and better serum profiles. Graphical Abstract Simvastatin-loaded PEGylated solid lipid nanoparticles: lipid functionalization to improve blood circulation.
Ankur Vaidya, Shweta Jain, Br Prashantha Kumar, Shashank K. Singh, Sushil Kumar Kashaw, and Ram Kishore Agrawal
Springer Science and Business Media LLC
Abstract A 3D QSAR study was performed on 1,2,4-oxadiazole derivatives using the [(SW) kNN MFA], CoMFA, and CoMSIA techniques. On the basis of 3D QSAR outcomes, new molecules were designed by substituting different substituents. These designed compounds were synthesized and confirmed their synthesis by spectroscopic techniques. The synthesized compounds were screened for their anticancer activity against different cancer cell lines. Compound 2-[3-(pyridine-4-yl)-1,2,4-oxadiazol-5-yl]benzo[ d ]thiazole showed equipotent (IC 50 = 4.96 μM) as 5-fluorouracil (IC 50 = 3.2 μM) against colon (CaCo-2) cancer cell line, and compound [2-[3-(pyridin-4-yl)-1,2,4-oxadiazol-5-yl]benzo[ d ]thiazol-4-yl]methanol showed equipotent activity (IC 50 = 0.35 μM) as compared to 5-fluorouracil (IC 50 = 0.23 μM) against colorectal (DLD1) cancer cell line. Compound 2-[3-(3,4-dimethoxyphenyl)-1,2,4-oxadiazol-5-yl]benzo[ d ]thiazole was found to be 4–5 less potent (IC 50 = 19.40 μM) as paclitaxel (IC 50 = 4.10 μM) against breast (T47D) cancer cell line, and compound 4-[5-(benzo[ d ]thiazol-2-yl)-1,2,4-oxadiazol-3-yl]benzene-1,2-diol was found about 10 times less potent (IC 50 = 15.7 μM) than mitomycin (IC 50 = 1.50 μM) against prostate (PC-3) cancer cell line. These results disclose the discovery of new 1,2,4-oxadiazole-based anticancer drugs. Graphic abstract
Ankur Vaidya, Shweta Jain, Sanjeev Sahu, Pankaj Kumar Jain, Kamla Pathak, Devender Pathak, Raj Kumar, and Sanjay Kumar Jain
Bentham Science Publishers Ltd.
Traditional cancer treatment includes surgery, chemotherapy, radiotherapy and immunotherapy that are clinically beneficial, but are associated with drawbacks such as drug resistance and side effects. In quest for better treatment, many new molecular targets have been introduced in the last few decades. Finding new molecular mechanisms encourages researchers to discover new anticancer agents. Exploring the mechanism of action also facilitates anticipation of potential resistance mechanisms and optimization of rational combination therapies. The write up describes the leading molecular mechanisms for cancer therapy, including mTOR, tyrosine Wee1 kinase (WEE1), Janus kinases, PI3K/mTOR signaling pathway, serine/threonine protein kinase AKT, checkpoint kinase 1 (Chk1), maternal embryonic leucine-zipper kinase (MELK), DNA methyltransferase I (DNMT1), poly (ADP-ribose) polymerase (PARP)-1/-2, sphingosine kinase-2 (SK2), pan-FGFR, inhibitor of apoptosis (IAP), murine double minute 2 (MDM2), Bcl-2 family protein and reactive oxygen species 1 (ROS1). Additionally, the manuscript reviews the anticancer drugs currently under clinical trials.
Shweta Jain, Vikash Chandra, Pankaj Kumar Jain, Kamla Pathak, Devendra Pathak, and Ankur Vaidya
Elsevier BV
Abstract Among heterocyclic compounds, quinoline scaffold has become an important construction motif for the development of new drugs. Quinoline and its derivatives possess many types of biological activities and have been reported to show significant anticancer activity. Quinoline compounds play an important role in anticancer drug development as they have shown excellent results through different mechanism of action such as growth inhibitors by cell cycle arrest, apoptosis, inhibition of angiogenesis, disruption of cell migration and modulation. A number of quinoline derivatives have been reported till date for their anticancer activity. The present review, summarizes various mono-, di-, tri-, tetra- and heterocyclic substituent quinoline derivatives with potential anticancer activity. Their mechanism of action and possible structure activity relationship has also been discussed.
Shweta Jain, Ankur Vaidya, Kamal Shah, Durgesh Nandini Chauhan, and Nagendra Singh Chauhan
Springer International Publishing
Sickle cell disease (SCD) is known to be one of the diseases wrecking most parts of the globe with 89% of sickle patients worldwide in Africa, of which Nigeria alone constitutes 25%. It was first reported by Dr. James Herrick in 1910 and the subsequent characterisation was by Linus Pauling. SCD is a genetic blood disorder, characterised by modification in the shape of the red blood cell from a smooth, donut shape into a crescent or half-moon shape. The practice of traditional medicine using medicinal plants has a long history in the treatment of sickle cell disease. The role of nutrition and anti-sickling effects of various phytoconstituents in overcoming SCD has been reported, although information on the management of SCD is still scarce.
Shweta Jain, Kamla Pathak, and Ankur Vaidya
Elsevier BV
RNA interference (RNAi) therapy, harnessed to produce a new class of drugs for treatment, has drawn attention and seen steady progress over the years. Molecular therapy using biological macromolecules small interfering RNA (siRNA) for gene silencing has received significant attention to target cancer-related genes. Basically, siRNA molecules bind to messenger RNAs (mRNA) by complementary base pairing, to induce degradation of the mRNA and/or block protein synthesis. Numerous genes and gene related proteins have been reported till date to target in siRNA based cancer therapy. Furthermore, a combination of siRNA with traditional anticancer drugs produces synergistic anticancer effect, or overcomes drug resistance, enhances targeting abilities and minimizes side-effects. Current review highlights various functional properties of genes that can be selectively knocked down by siRNAs. In addition, we have also discussed the interaction of siRNA-mediated gene-silencing with chemotherapeutic agents in nanoformulation which constitutes a valuable and safe approach for cancer treatment.
Shweta Jain, Satyanarayan Pattnaik, Kamla Pathak, Sushant Kumar, Devender Pathak, Surendra Jain, and Ankur Vaidya
Bentham Science Publishers Ltd.
This review brings forth the potential of thiazole derivatives for their anticancer activities. The emphasis is placed on the structural diversity of thiazole derivatives, responsible for their specific anticancer activity. Multiple classes of thiazole derivatives such as Schiff base, mono-, di-, tri-, and heterocyclic substituents that possess anticancer activity have been exemplified. Molecular modelling of compounds that predicts enhanced anticancer activity of the modified structures has also been elaborated in the review. Significant advancements in synthetic chemistry related to cytotoxicity can now better position the drug discovery team to undertake thiazoles as valuable leads. The beneficial thiazole derivatives possessing anticancer activity will reignite the interest of medicinal chemists in thiazole and their derivatives.
Shweta Jain, Ankur Vaidya, Abhishek Kumar Jain, Ram Kishore Agrawal, and Sushil Kumar Kashaw
Elsevier BV
Abstract Phosphodiesterases are a diverse family of enzymes that play a key role in regulating intracellular levels of the second messengers cAMP, cGMP and ultimate cell function. Selective PDE3B inhibitors were recognized to prevent oocyte maturation. In search of effective PDE3B inhibitors, the present study deals with 3D QSAR analysis on previously reported benzyl vinylogous derivative. The comparative molecular field analysis (CoMFA) studies resulted in reliable and remarkable computational models. The obtained CoMFA model showed high predictive ability with q 2 = 0.556, r 2 = 0.936 and standard error of estimation (SEE) = 0.231, explaining a majority of the variance in the data with four principal components. The result of the present study shows good correlation between descriptors and biological activity. On the basis of statistical significance of the generated model the results can be utilized in the design of new more potent benzyl vinylogous derivatives as PDE3B inhibitors.
Ankur Vaidya, Shweta Jain, Priyanka Jain, Prachi Jain, Nidhi Tiwari, Roshni Jain, Rashi Jain, Abhishek K. Jain, and Ram K. Agrawal
Bentham Science Publishers Ltd.
Recently, there has been wide interest in compounds containing the oxadiazole scaffold because of their unique chemical structure and their broad spectrum of biological properties. This review provides readers with an overview of the main synthetic methodologies for oxadiazoles and of their broad spectrum of pharmacological activities such as, anti-microbial, anti-fungal activity, antiviral, anti-tubercular, anti-inflammatory, anti-convulsant, anti-angiogenic, anti-proliferative, analgesic, anti-oedema and in alzheimer activity, which were reported over the past years.
Ankur Vaidya, Shweta Jain, Ram K. Agrawal, and Sanjay K. Jain
Elsevier BV
Abstract The present study explored the potential of pectin–metronidazole (PT–ME) prodrug bearing microspheres for colon delivery. PT–ME prodrug was synthesized with different degree of substitution. The success of the synthesis was confirmed by spectroscopy. PT–ME microspheres and pectin microspheres bearing plain metronidazole were prepared using emulsion-dehydration technique. Microspheres were evaluated for shape and surface morphology, size distribution, entrapment efficiency and in vitro drug release in simulated gastrointestinal fluids (SGF). Microspheres prepared from PT–ME prodrug were not only exhibiting increased the drug entrapment efficiency, but the drug release at the upper part of GIT was also reduced as compared to pectin microspheres having physically entrapped drug. In vitro drug release studies were showing no drug release at acidic pH from microspheres prepared by drug polymer prodrug while pectin microspheres having physically entrapped drug showed almost or complete drug release. In vivo studies were also performed by assessing the drug concentration in various parts of the GIT at different time intervals which exhibited the potentiality of microspheres prepared from PT–ME prodrug as compared to pectin microspheres having physically entrapped drug. Hence, it can be concluded that microspheres prepared from PT–ME prodrug deliver the drug more efficiently to colon.
Ankur Vaidya, Shweta Jain, Abkishek K. Jain, B. R. Prashanthakumar, Sushil K. Kashaw, and Ram K. Agrawal
Springer Science and Business Media LLC
Quantitative structure–activity relationship (QSAR) is an attempt to correlate structural or property descriptors of compounds quantitatively with biological activities. QSARs currently are being applied in many disciplines, with many pertaining to drug design and environmental risk assessment. The 3D QSARs between the structures of 29 quinoline compounds and their topoisomerase-II inhibitor activity have been developed using the comparative molecular field analysis (CoMFA), comparative molecular similarity indices analysis (CoMSIA), and stepwise k nearest neighbor molecular field analysis [(SW) kNN MFA] method, and 3D QSAR models with the considerable prediction ability are obtained. The CoMFA, CoMSIA, and [(SW) kNN MFA] studies resulted in reliable and significant computational models. These models are more significant guide to trace the important chemical features with respect to the design of new potent compounds. The information obtained from the CoMFA, CoMSIA, and [(SW) kNN MFA] contour maps can be utilized for the design and development of new, more potent topoisomerase-II inhibitor.