Mayank Kulshreshtha

Scopus Publications

Formulation and Comparison of Herbal Gels Containing Essential Oils and their Antimicrobial Evaluation
Karan Agrawal, Vibha, Yogesh Murti, Migul Agrawal, and Mayank Kulshreshtha
Bentham Science Publishers Ltd.
Objective: The current study aimed to formulate and evaluate herbal gels con-taining essential oils for the treatment of infection caused by microbial species, i.e., S. au-reus, E. coli, P. aeruginosa, and B. subtilis. These species are also responsible for acne directly and indirectly. Material and Methods: The gels were prepared using a gelling agent with 1% Carbopol-940, and they were further evaluated for physical appearance, drug content, in-vitro drug release, viscosity, extrudability, pH, and spreadability. Further, anti-microbial screening was done with various microbial species. Results: Studies revealed that the gel was highly effective against the selected species ex-cept for the fungal strain. ZOI was observed ranging from 3.1 ± 0.01 mm to 13.4 ± 0.14 mm. The maximum ZOI was observed at 13.4 ± 0.14 mm against S. aureus. The physical properties of the gel satisfied the standard parameters. Conclusion: The prepared herbal gel was found to have highly promising activity against bacterial species associated with bacterial infection but in a dose-dependent manner. How-ever, more research is required.

Pharmacological investigation of Achras sapota against scopolamine induce amnesia and cognitive impairment in laboratory animals
Khushboo Singh, Yogesh Murti, Anuj Kumar Sharma, Dharamveer, Akash Ved, Sachdev Yadav, and Mayank Kulshreshtha
Elsevier BV

A comprehensive review on Chinese honeysuckle (Qusqualis indica): A Traditional Chinese plant
Anuj Kumar Sharma, Deepti M. Sati, Yogesh Murti, Akash Ved, Sachdev Yadav, Arpita Singh, Anita Singh, Manjul Pratap Singh, Amit Kumar Nigam, Karuna Shanker Shukla,et al.
Elsevier BV

A mini review on Aconitum ferox: A traditional Chinese plant
Anuj Kumar Sharma and Mayank Kulshreshtha
Elsevier BV

Characterization of different screened proteins from Chinese honeysuckle leaves and evaluate their antimicrobial potential
Mayank Kulshreshtha, Anuj Kumar Sharma, Yogesh Murti, Vibha, Neeraj Verma, Anita Singh, Soumyadip Mukherjee, Amit Nigam, and Manjul Pratap Singh
Elsevier BV

Medicinal Plants in the Treatment of Tuberculosis: A Systematic Review
Radha Agrawal, Yogesh Murti, Mohit Mangla, Mohit Sandhuja, Anuj Kumar Sharma, Vibha Kumari, and Mayank Kulshreshtha
Bentham Science Publishers Ltd.
Introduction: Tuberculosis is the most common disease that affects the lungs, and it is associated with Mycobacterium tuberculosis infection. Many synthetic medications, such as pyrazinamide, isoniazid, and ethambutol, are available to treat TB; however, their adverse effects are severe. Medicinal herbs have lately become popular, safe, and effective alternative treatments for TB. Method: The purpose of this review was to assess the possible use of natural plants in the development of herbal treatments and remedies for TB by studying the medicinal plants and phytochemicals that have been used for the disease. Information was gathered from a variety of sources, including Bentham, Elsevier, Springer, Nature, Google Scholar, PubMed, Sci-Finder, and the Web of Science. For the investigation, common and scientific names of plants, as well as terms like "mycobacterium tuberculosis," "herbal plants," "flavonoids," and "alkaloids" were employed. In the end, 376 plants belonging to 83 families were discovered, and details about each plant family, as well as the section of the plant utilized, chemical components, extract, and strain, were extracted. Result: The findings showed that although flavonoids and alkaloids were the most prevalent naturally occurring substances found in plants, the Fabiaceae family had a greater potential to eradicate TB. Conclusion: The leaf portion was shown to be more active, and the S-37 RV strain of Mycobacterium TB was employed more frequently.The leaf portion was shown to be more active, and the S-37 RV strain of Mycobacterium TB was employed more frequently.

Development and Evaluation of Celecoxib Emulgel by Using Natural Oil
Aarti Rajput, Rishabh Gaur, Mayank Kulshreshtha, Sumedha Singh Jadaun, and Vibha Kumari
Bentham Science Publishers Ltd.
Background: Emulgel combines the qualities of an emulsion with those of a gel. In order to create an emulgel w/o or o/w, emulsions have to be formulated, which are then com-bined with a gelling agent, resulting in a dual-control drug release. Celecoxib exhibits analge-sic, antipyretic and anti-inflammatory activities and is used to treat osteoarthritis, severe pain, rheumatoid arthritis, and other medical conditions. Methods: Celecoxib Emulgel was developed and evaluated by using natural oil and carbopol-940 as a gelling agent in different concentrations. The screening of various oils, co-surfactants and surfactants was performed to determine the solubility. The essential oils (eucalyptus oil and turpentine oil) were used as penetration modifiers. Studies on compatibility with polymers have been conducted, and the results indicate that there should be no physical or chemical interactions between the polymers and the drug substance. For the preparation of emulgel, various emulsions were prepared with Smix (cosurfactant and surfactant) ratios (1:1, 2:1 and 3:1). The selection of a gelling agent was done by incorporating the selected emulsion system ratio of 1:1 with the combinations of polymers carbapol 940, carbapol 934, and HPMC (0:1:0, 0:0.5:1, 0:0:3, 0.5:0:1, 1:0:0) gel base to make a homogenous emulgel. Results: The emulgel was examined visually to see if it had any phase behaviour, feel, spread-ability, and grittiness by applying its thin layer to a slide. Then, all six formulations of emulgel were prepared with the selected gelling agent. All emulgels were evaluated for pH, physical properties (consistency, homogeneity, colour, texture), drug content, spreadability, extrudabil-ity, swelling index, viscosity, stability and centrifugation. A Franz diffusion cell and an egg membrane were used to perform in-vitro drug release. Conclusion: Among all prepared formulations, EG1 had a better release, higher viscosity, higher drug content, and a higher swelling index than the others. The formulation EG1 showed higher drug release (91.25%) within 8 hours.

Medicinal Plants in the Treatment of Myocardial Infarction Disease: A Systematic Review
Anamika Rathore, Anuj Kumar Sharma, Yogesh Murti, Sonal Bansal, Vibha Kumari, Varsha Snehi, and Mayank Kulshreshtha
Bentham Science Publishers Ltd.
Background: Myocardial infarction (MI), also referred to as a "heart attack," is brought on by a partial or total interruption of blood supply to the myocardium. Myocardial infarction can be "silent," go undiagnosed, or it can be a catastrophic occurrence that results in hemodynamic decline and untimely death. In recent years, herbal remedies for MI have become effective, secure, and readily accessible. Objective: The purpose of this review was to examine the medicinal plants and phytochemicals that have been used to treat MI in order to assess the potential contribution of natural substances to the development of herbal MI treatments. Methodology: A literature search was employed to find information utilizing electronic databases, such as Web of Science, Google Scholar, PubMed, Sci Finder, Reaxys, and Cochrane. Results: The identification of 140 plants from 12 families led to the abstraction of data on the plant families, parts of the plant employed, chemical contents, extracts, model used, and dose. Conclusion: The majority of the MI plants, according to the data, belonged to the Fabaceae (11%) and Asteraceae (9%) families, and the most prevalent natural components in plants with MI were flavonoids (43%), glucosides (25%), alkaloids (23%), phenolic acid (19%), saponins (15%), and tannins (12%).

Molecular Pathways and Treatment Updates on Huntington’s Disease with Special Preference to Juvenile Phase: A Comprehensive Review
Kunal Suryavanshi, Anuj Kumar Sharma, Yogesh Murti, Vibha Kumari, Karuna Shanker Shukla, and Mayank Kulshreshtha
Bentham Science Publishers Ltd.
Abstract:: A degenerative brain ailment called Huntington's disease (HTD) causes irritable behavior, emotional distress, cognition, etc. It is also known as Huntington's chorea. Compared to men, women are more likely to get HTD. However, in India, if 3 to 5% of Europeans are affected, it is difficult to estimate the disease's prevalence. The full pathophysiological status, several molecular pathways, and pharmaceutical and non-pharmacological treatments for Huntington's disease are covered in this article. Google, PubMed, Scopus, Bentham, Elsevier, and other significant web resources were used to gather the scientific data. Moreover, this review article may serve as the foundation for future study, particularly on Huntington's illness.

Molecular Pathway, Epidemiological Data and Treatment Strategies of Fungal Infection (Mycoses): A Comprehensive Review
Namrata Singh, Vibha Kumari, Karan Agrawal, and Mayank Kulshreshtha
Bentham Science Publishers Ltd.
Abstract: The recent increase in fungal infections is a health crisis. This surge is directly tied to the increase in immunocompromised people caused by changes in medical practice, such as the use of harsh chemotherapy and immunosuppressive medicines. Immunosuppressive disorders such as HIV have exacerbated the situation dramatically. Subcutaneous or superficial fungal infections can harm the skin, keratinous tissues, and mucous membranes. This category includes some of the most common skin disorders that impact millions of people worldwide. Despite the fact that they are seldom fatal, they can have a catastrophic impact on a person's quality of life and, in rare situations, spread to other people or become obtrusive. The majority of fungal infections under the skin and on the surface are simply and quickly cured. An opportunistic organism that preys on a weak host or a natural intruder can both result in systemic fungal infections. Furthermore, it might be exceedingly lethal and dangerous to one's life. Dimorphic fungi may pose a hazard to healthy populations that are not exposed to endemic fungi. Increased surveillance, the availability of quick, noninvasive diagnostic tests, monitoring the emergence of antifungal medication resistance, and research on the pathophysiology, prevention, and management of fungal infections are just a few potential solutions to these new health problems. The goal of this review is to summarize the data available for fungal infections and the different therapies which are involved in their treatment. Additionally, it also summarizes the molecular and scientific data of the plants which contain anti-fungal activity. Data are acquired using Google, PubMed, Scholar, and other online sources.

Formulation and evaluation of Chinese eucalyptus oil gel by using different gelling agents as an antimicrobial agent
Deepshikha Dubey, Vibha, Yogesh Murti, Pranay Wal, Akash Ved, Parshant Kumar, Anuj Kumar Sharma, Harinath Dwivedi, Anita Singh, Manjul Pratap Singh,et al.
Elsevier BV

Anti-diabetic potential of Aconitum ferox roots
Pragati Srivastava, Yogesh Murti, Dharamveer Panjwani, and Mayank Kulshreshtha
Elsevier BV

Preparation and evaluation of different herbal gels synthesized from Chinese medicinal plants as an antimicrobial agents
Chirag Upadhyay, Vibha, Devender Pathak, and Mayank Kulshreshtha
Elsevier BV

Botanical, phytochemical and pharmacological aspects of Livistona chinensis: A traditional Chinese plant
Kehar Singh, Yogesh Murti, Mohit Sanduja, Anuj Kumar Sharma, Vibha, Sonal Bansal, Karuna Shanker Shukla, and Mayank Kulshreshtha
Elsevier BV

HPTLC Studies, in silico Docking Studies, and Pharmacological Evaluation of Elaeocarpus ganitrus as a Gastroprotective Agent
Mayank Kulshreshtha, Anuj Kumar Sharma, Rajaneesh Kumar Chaudhary, Swetza Singh, Akash Ved, Karuna Shanker Shukla, Anita Singh, and Manjul Pratap Singh
Bentham Science Publishers Ltd.
Objectives: Elaeocarpus ganitrus, a member of the Eleocarpaceae family, is valued in Hinduism and Ayurveda, and is frequently used as a remedy for a variety of illnesses. The plant is reputed to treat a number of stomach issues. The purpose of the study was to produce high-quality scientific data regarding gastroprotective behavior, docking experiments with cholinergic receptors, and HPTLC (with lupeol and ursolic acid). To develop the mechanism of herbal extracts, in vitro anticholinergic and antihistaminic activities were evaluated. Different leaf extracts were treated with various reagents to determine the presence of various metabolites. An examination of the histopathology was conducted to determine the full impact of the extract. Methods: Methanolic extract was chosen for HPTLC investigations after extraction with various solvents. A mobile phase of toluene, ethylacetate, and formic acid (8:2:0.1) was chosen. Molecular docking was utilized to examine how ursolic acid and lupeol are bound to cholinergic receptors (M3). Different extracts (aqueous and ethanolic) were tested for their ability to provide gastroprotection in Wistar rats at different doses (200 and 400 mg/kg). Results: Phytochemical analysis of different extracts showed the presence of different primary and secondary metabolites. HPTLC data showed the presence of both standards. Docking studies exhibited very good interactions with the M3 receptor. Pharmacological studies revealed that extract-treated groups significantly reduced the ulcer index in all of the models mentioned above. The histopathological analysis clearly supports the biochemical studies, which were conducted utilizing various doses and found to be effective in a dose-dependent manner. The in vitro analysis proved that the abovementioned extracts may act as antagonists of acetylcholine and histamine. Conclusion: The data obtained would be valuable for the production of the monograph of the plant and conducting concept-related clinical studies in the future. More investigation is required since the gathered scientific data may lead to new research opportunities.

An Update on New Cholesterol Inhibitor: Bempedoic Acid
Mayank Kulshreshtha
Bentham Science Publishers Ltd.
: An increase in the level of cholesterol day by day is easily seen in most people just because of poor life style, food with high cholesterol, lack of physical work, etc. There are lots of molecules available, which lower down the cholesterol level. In this field a new molecule has been introduced that is bimpedoic acid. Researches indicate that bempedoic acid has the same mechanism of action as statins, which means that it also inhibits the HMG-CoA reductase enzyme. This letter to the editor is my best collection of published scientific data on bempedoic acid till now. It also includes the chemistry, pharmacodynamic and pharmacokinetic parameters of the mentioned new molecule.

Design, synthesis, characterization and in silico molecular docking studies and in vivo anti-inflammatory activity of pyrazoline clubbed thiazolinone derivatives
Deepak Kumar Singh, Mayank Kulshreshtha, Yogesh Kumar, Pooja A. Chawla, Akash Ved, and Karuna Shanker Shukla
Bentham Science Publishers Ltd.
The pyrazolines give the reactions of aliphatic derivatives, resembling unsaturated compounds in their behavior towards permanganate and nascent hydrogen. This nucleus has been associated with various biological activities, including inflammatory action. Thiazolinone is a heterocyclic compound that contains both sulfur and nitrogen atom with a carbonyl group in their structure. Thiazolinone and their derivatives have attracted continuing interest because of their various biological activities, such as anti-inflammatory, antimicrobial, anti-proliferative, antiviral, anticonvulsant, etc. The aim of the research was to club pyrazoline nucleus with thiazolinone in order to have a significant anti-inflammatory activity. The synthesized compounds were chemically characterized for the establishment of their chemical structures and to evaluate it as an anti-inflammatory agent. In the present work, eight derivatives of substituted pyrazoline (PT1-PT8) were synthesized by a threestep reaction. The compounds were subjected to spectral analysis by Infrared, Mass, and Nuclear magnetic resonance spectroscopy and elemental analysis data. All the synthesized derivatives were evaluated for their in vivo anti-inflammatory activity. The synthesized derivatives were evaluated for their affinity towards target COX-1 and COX-2, using indomethacin as the reference compound molecular docking visualization through AutoDock Vina. Compounds PT-1, PT-3, PT-4, and PT-8 exhibited significant anti-inflammatory activity at 3rd hour, being 50.7%, 54.3%, 52.3%, and 57%, respectively, closer to that of the standard drug indomethacin (61.9%). From selected anti-inflammatory targets, the synthesized derivatives exhibited better interaction with COX-1 and COX-2 receptor, where indomethacin showed a docking score of -6.5 kJ/mol, compound PT-1 exhibited the highest docking score of -9.1 kJ/mol for COX-1 and compound PT-8 had a docking score of 9.4 kJ/mol for COX-2. It was concluded that synthesized derivatives have more interaction with COX-2 receptors in comparison to the COX-1 receptors because the docking score with COX-2 receptors was very good. It is concluded that the synthesized derivatives (PT-1 to PT-8) are potent COX-2 inhibitors.

A biological active mushroom agaricus bisporus: An update of its phytopharmacology and medicinal properties with respect to various diseases

Endocrine and Therapeutic Basis of Diabetes Mellitus Therapy
Mayank Kulshreshtha, Pragati Srivastava, and Dharamveer Panjwani
BSP Books Private Limited
 This review article describes the role of hormones, microvascular complications, pharmacological and non-pharmacological treatments and precautions of diabetes therapy. Diabetes mellitus (DM) is a chronic, lifelong condition that affects ability to use the energy found in food. According to World Health Organization (WHO), it is estimated 422 million adults are suffered with DM up to latest 2016 data. It occurs throughout the world but is more common in the more developed countries. Increase in prevalence is occurring in low- and middle-income countries including in Asia and Africa, where most patients will probably be found by 2030. The WHO estimates that diabetes resulted in 1.5 million deaths in 2012, making it the 8th leading cause of death. We summarized the published scientific data and new development in the field of diabetes with a search of PubMed, Google scholar, med know and other online resources. Various hormones play an important role in which insulin has a more importance in DM. Pharmacological treatment included various side effects while herbal drugs are found to be safe. Diet and exercise are the excellent key points to cure the disease. Avoid high sugar diet and various foods whose sugar levels are high should be avoided at the age 40. Overall, better knowledge, balanced life style, and daily exercise are the excellent treatment of diabetes and effective glucose control.

Pharmacological approach of pistacia vera fruit to assess learning and memory potential in chemically-induced memory impairment in mice
Satyam Singh, Dharamveer, and Mayank Kulshreshtha
Bentham Science Publishers Ltd.
Objective: The present study was designed to investigate the potential of Pistacia vera (P. vera) fruits in experimental memory impairments in mice. Material & Methods: Memory impairment was induced in Swiss Albino mice by scopolamine (0.4mg mg/kg. i.p). Animals were divided into five separate groups of six animals each, positive control group received carboxy methyl cellulose (CMC) as vehicle, negative control group received scopolamine with vehicle, and standard group received donepezil (5mg/kg i.p) with Scopolamine. Ethanolic extract of P. vera (EEPV) at doses of 200mg/kg & 400mg/kg p.o were administered to group test1 & test 2 respectively along with scopolamine. Elevated plus maze (EPM), passive avoidance paradigms and morris water maze (MWM) were used as exteroceptive behavioral models to access learning and memory activity. Transfer latency, step down latency and escape latency parameters were evaluated plus maze, passive avoidance paradigm, morris water maze. Thereafter lipid peroxidation test, glutathione level and catalase activities were estimated in homogenized brain of mice. Results: Pretreatment of mice with EEPV (200mg/kg & 400mg/kg) significantly reduced scopolamine induced amnesia. The obtained data clearly revealed that there was increase in escape latency in MWM and also increase in step down latency in passive avoidance paradigm. Transfer latencey was found to be decrease in EPM and biochemical. Parameters were clearly satisfied the data as compared to negative control group which was indicative of cognitive improvement. Conclusion: P. vera fruit extract demonstrated to improve cognitive process by enhancing memory in different experimental paradigm such as EPM, passive avoidance and MWM when administered orally. Hence it would be worthwhile to explore the potential of this plant in the management of memory disorders.

Cardioprotective activity of agaricus bisporus against isoproterenol- induced myocardial infarction in laboratory animals
Apoorva Bhushan and Mayank Kulshreshtha
Bentham Science Publishers Ltd.
Background: Agaricus bisporus (A. bisporus) is an edible basidiomycete mushroom native to grasslands in Europe and North America. A. bisporus, commonly known as white button mushroom (WBM), is widely cultivated in most countries, and it constitutes the bulk of all mushrooms consumed in the United States and Australia. Traditionally this fungus has used in the treatment of heart diseases. Also it has anti-ageing property.Mushrooms have been found effective against cancer, cholesterol reduction, stress, insomnia, asthma, allergies and diabetes. Objective: The present research was designed to appraise the cardioprotective activity of a hydroalcoholic extract of Agaricus bisporus (EEAB) on Isoproterenol (ISO) induced myocardial infarction (MI) in Albino Wistar rat. Traditionally, Agaricus bisporus is reported in the treatment of heart diseases, cancer, cerebral stroke and anti-ageing property. Materials and Methods: Wistar rats of different sex were randomly split into five groups namely positive control, negative control, standard, test-1 and test-2 and received distilled water, ISO (85 mg/kg), Simvastatin (10 mg/kg/day, oral) and EEAB (200 and 400 mg/kg/day, p.o.) for 30 days, respectively. MI was induced in rats by ISO at an interval of 24 hrs on 31 and 32 day and on the next day, blood was amassed through retro-orbital plexus for the assessment of biochemical markers (cholesterol, lowdensity lipoprotein, high-density lipoprotein, very low-density lipoprotein, triglycerides, alanine aminotransferase and total protein) and finally, the rats were immolated by cervical dislocation. The heart tissue was reaped instantly, cleaned with chilled isotonic saline and clasped in 10% buffered formalin and used for the histopathological analysis. Results: ISO p.o. administration significantly elevated the cholesterol, low density lipoprotein, very low density lipoprotein, triglycerides, alanine aminotransferase and aspartate aminotransferase levels while it decreases high-density lipoprotein and total protein in plasma and administration of EEAB decreases the level of cholesterol, low-density lipoprotein, very low-density lipoprotein, triglycerides, alanine aminotransferase and aspartate aminotransferase levels while it increases high-density lipoprotein and total protein levels. Pretreatment with EEAB protected the cardiotoxicity induced by ISO. The histopathological findings support the analysis of biochemical parameters, ISO-induced myocardium showed infracted zone with edema, inflammatory cells, lipid droplets, myocardial necrosis and vacuolization of myofibrils which were reduced. Conclusion: It can be an outcome that EEAB possessed cardioprotective activity against experimental and clinical studies of ISO-induced myocardial infarction in rats.

Pharmacognostical, phytochemical and pharmacological aspects of quisqualis indica: An update
M. Kulshreshtha, K. Shukla, Garima Tiwari, Manjul Singh and Anita Singh

Nature is a big and important source of lots of things, in which plants are the living gifts of nature. Plants play an important role in various fields, but the role of these plants as herbal medicines is a big achievement. Drugs are obtained from plants have very low side effects and very popular in worldwide. Here, this review represents the pharmacology, pharmacognosy, and various molecular aspects of Quisqualis indica which may be helpful in near future based on available published data. This review opens the various doors or acts as a backbone for various researches in near future.

The medicinal mushroom agaricus bisporus: Review of phytopharmacology and potential role in the treatment of various diseases
Apoorva Bhushan and M. Kulshreshtha

Nature has been a source of medicinal agents for thousands of years and an impressive number of modern drugs have been isolated from natural sources, based on their use in traditional medicine. Since ancient time's plants as well as fungus sources of medicinal compounds have continued to play a dominant role in maintenance of human health. Over 50% of all modern clinical drugs are of natural product origin and play an important role in drug development programs in the pharmaceutical industry. Mushrooms are an important natural source of food and medicine. Traditional aboriginals knew the importance of edible and wild mushrooms, and these are now being screened for their bioactivity in various ailments. We are aiming for this review is to compact a compressive scientific description of pharmacognosy, chemistry, and pharmacology of button mushroom (Agaricus bisporus), depending on published data and other available resources.

Pharmacological investigation and unraveling mechanism of action of Jasminum sambac flowers for predicated treatment of Alzheimer’s disease
Jyoti Gupta and Mayank Kulshreshtha
Bentham Science Publishers Ltd.

Memory Impairment with Reference to Alzheimer's Disease: An Update
Mayank Kulshreshtha and Jyoti Gupta
Medknow
Dementia or memory loss is the hallmark symptom of Alzheimer’s disease (AD). The exploration of AD helps to identify the problems involved in neural structures such as the default network and role of genetic factors. Episodic memory (EM) directly deals with the memory system that allows an individual to consciously retrieve an old experience or an episode of life. EM plays an important role in AD. The World Health Organization predicts that, by 2025, about 75% of the estimated 1.2 billion people aged 60 years and older will reside in developing countries. It is estimated that the number of people living with dementia will almost double every 20 years to 42.3 million in 2020 and 81.1 million in 2040. In India, there are lesser number of good quality scientific studies/researches that deal with the real trend of the disease and determine the mechanism involved, risk factors, investigations on dementia, decline in awareness, and inadequate availability of social benefit. India is a country with varied cultures, and, therefore, conducting a genetic epidemiological study here has greater advantage. The goal of this review is to provide knowledge and increase the awareness of dementia associated with AD, as well as to understand the mechanism involved and its treatment, which can be useful for researchers or scientists in the near future.

Mayank Kulshreshtha

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Scopus Publications