Dr. Ramanlal Narayan Kachave

@msgpharma.org

Professor, Department of Pharmaceutical Chemistry
Gokhale Education Society's, Sir Dr. M. S. Gosavi College of Pharmaceutical Education and Research Nashik, Affiliated Savitribai Phule Pune University, Pune

Dr. Ramanlal Narayan Kachave


                  Download Compact PDF  
https://researchid.co/rpuhplc
Brief Profile: 16 years of Professional experience in academics and served at different level as Lecturer, Assistant Professor, PG and Ph. D Guide etc and Currently Serving as the Assocaite Professor at R.G. Sapkal College of Pharmacy, Nasik. Completed a PhD in Pharmaceutical Sciences from the JNTU, Kakinada (AP) and M. Pharmacy in Pharmaceutical Chemistry from School of Pharmaceutical Sciencs, RGPV, Bhopal (M.P). Received Savitribai Phule Pune University, Pune’s BCUD Two minor research project grant of Rs 3.0 lakhs. Qualified GATE examination Conducated by IIT, Mumabi 2005.

EDUCATION

M. Pharmacy , Pharmaceutical Chemistry

Ph. D. , Pharmaceutical Science

RESEARCH INTERESTS

Analytical and Bioanalytical Method Development and Validation
Impurity Profiling Study
Stability Indicating Assay Methods

FUTURE PROJECTS

Bioanalytical Method Development and Validation of Antihyperuricemic Drug in human Urine Sample by Liquid Chromatography-Mass Spectrometry


Applications Invited
28

Scopus Publications

Scopus Publications

  • A REVIEW OF PHARMACOGENETIC STUDIES CONCERNING GENETICS AND TREATMENT RESPONSE IN PARKINSON'S DISEASE
    Gajanand Pujari, G. Neethirajan, Arman Dalal, Ramanlal Narayan Kachave, Anuradha Pannu, et al.
    Bio Web of Conferences, 2026
    Parkinson’s disease (PD) is a neurodegenerative disorder that progressively deteriorates the nervous system. Its causes are multifaceted, involving environmental influences, genetic predispositions, and epigenetic modifications. The main and inciting symptoms of PD are a combination of motor (bradykinesia, rest tremor and rigidity) and non-motor (hallucinations, compulsive behaviours and sleep disorders) symptoms. The existing treatments are mainly composed of a combination of medications that focus on treating the symptoms of the disease by replacing the lost dopamine without identifying the cause of the disease. Although beneficial, these therapies display a concerning amount of heterogeneity in drug response. Pharmacogenetics, a part of pharmacogenomics, helps to highlight the genetic factors that contribute to such heterogeneity in drug response. In the treatment of patients with PD, pharmacogenetic studies are particularly important given the variability of results, primarily concerning levodopa and dopaminergic therapies. This review covers the genetic mutation related to PD genes such as LRRK2, SNCA, and PARK2, which will be taken into account concerning their effects on disease progression and drug response. Genetic polymorphisms can significantly modulate the efficacy and adverse effects of drugs in patients with PD, influencing drug metabolism, transport, and receptor binding, among others, and involve genes such as CYP2D6 and COMT. This would be achieved through the application of pharmacogenetic insights that allow for tailored therapy approaches, optimize dosages, reduce adverse effects, and ensure better patient outcomes. Personalized medicine in PD could potentially enable improvement in treatment strategies based on an individual's genetic profile and thereby enhance management for this complex disease.
  • Polymer Nanocomposite Reinforcement Strategies
    Dattatraya Manohar Shinkar, Unmesh Gulabrao Bhamare, Prakash Pannalal Muleva, Deepali Dattatray Bhandari, Ramanlal Narayan Kachave, et al.
    Polymer Nanocomposites Advances in Design Synthesis and Applications, 2026
  • Impurity profiling and forced degradation studies of angiotensin (AT1) blockers: A review
    Ramanlal N. Kachave, Deepali D. Bhandari, Prashant L. Pingale, Dattatraya M. Shinkar, Sunil V. Amrutkar
    Current Pharmaceutical Analysis, 2025
  • Pitfalls of Drug Repurposing and Lesson Learned from COVID-19
    Sandeep Purkar, Ramanlal Kachave, Shilpa Harak, Dhanashri Mali, Deepali Bhandari
    Drug Repurposing for Antivirals, 2025
    The new beta coronavirus responsible for the current COVID19 pandemic had started to spread among people towards the end of 2019. Unmatched global searches were conducted to identify and reuse antiviral drugs from lists of approved drugs and recognised bioactive compounds. Antiviral drug development standards were rapidly circumvented, which often led to unsatisfactory results. The main drawbacks of this technique include promiscuous or cytotoxic compounds resulting in false positives. Several articles, press announcements, and media posts misled readers and occasionally diverted important attention from the search for reusable drugs. Funding for clinical trials with a low possibility of success, the empirical identification of factors that mitigate clinical indicators—such as the development of better disease management through immunomodulators and promiscuous/cytotoxic substances that cause inaccurate results—has led to breakthroughs in the clinic instead of in the lab.
  • Exploring Herbal Remedies: Traditional Wisdom Meets Modern Science
    Deepali D. Bhandari, Komal S. Hatkar, Sharayu P. Rathod, Ramanlal R. Kachave, Sunil V. Amrutkar, et al.
    Herbal Nanotherapy for Diabetes, 2025
    This review examines how traditional medicine and recent science can coexist in the branch of herbal drugs, emphasizing the safety and effectiveness of natural therapies in modern healthcare. The long history of herbal remedies, which are ingrained in cultural customs, is experiencing a revival in tandem with the growing demand for customized and all-encompassing healthcare. Diabetes mellitus (DM) is a severe long-term metabolic condition that is linked to hyperglycemia and several side effects, such as chronic kidney disease and cardiovascular disease. A long-standing practice that has been handed down through the years, herbal medicine is gaining popularity again as its potential advantages become more widely recognized. The antihypoglycaemic properties of the phytochemicals found in medicinal plants (Allium sativum, Momordica charantia, Hibiscus sabdariffa L., and Zingiber officinalis) can overcome and/or prevent diabetes mellitus. The results also showed that vitamin C, D, E, or their mixture lowers blood pressure, lipid peroxidation, blood glucose, and inflammation in diabetic individuals. The health advantages of vitamins and medicinal plants as chemotherapeutic/preventive medicines for the control of diabetes, however, have not been well studied. It explores the safety profiles of herbal treatments and applies a rigorous scientific examination to them. This review aims to investigate and analyze DM and to close the information gap by examining diabetes mellitus (DM) and emphasizing the hypoglycaemic qualities of the most effective medicinal herbs and vitamins that can avoid and/or lower DM. This review contributes to the ongoing conversation in a world where combining modern science and ancient wisdom holds promise for improving healthcare. The intention is to improve global well-being by combining the best aspects of both worlds.
  • Comparative antifungal potential of six formulated herbal shampoos against Candida albicans causing Seborrheic dermatitis
    Harshada Chattar, Bhushan Pimple, Mohini Kuchekar, Harshal Tare, Vijay Wagh, et al.
    Microbial Biosystems, 2024
    Cosmetics have been used by humans since centuries for variety of purposes, including enhancing appearance, protection and cleansing. Herbal ingredients have been used in cosmetics for their natural and beneficial properties. When combined, herbal ingredients and cosmetics can provide a number of benefits, including improved skin health, protection from the sun and a
  • HIV/AIDS neurological disorders
    Ankit Kumar Saini, Abhishek Amod Gupta, Raj K. Keservani, Ramanlal N. Kachave, G. Dharmamoorthy, et al.
    A Review on Diverse Neurological Disorders Pathophysiology Molecular Mechanisms and Therapeutics, 2024
  • Pathogenesis and treatment of rabies
    Ankit Kumar Saini, Abhishek Amod Gupta, Raj K. Keservani, Ramanlal N. Kachave, Rajesh K. Kesharwani, et al.
    A Review on Diverse Neurological Disorders Pathophysiology Molecular Mechanisms and Therapeutics, 2024
  • Catechins as Catalase Modulators: A Comprehensive In-silico Analysis Unveiling their Potential Antioxidant Effects
    Harshal Tare, Ujjwala Thube, Ramanlal Kachave, Vijay Wagh, Babaso Udugade
    International Journal of Drug Delivery Technology, 2023
    This research explores the potential of carefully selected catechins as catalase modulators, leveraging their documented antioxidant effects. The catalase protein’s structural quality was rigorously evaluated, revealing an overall high-quality 3D structure. Ligand-based virtual screening identified ten novel catechin hits with promising interactions, presenting candidates designed for new validation. Molecular docking simulations demonstrated robust binding empathies between selected catechins and catalase, with CHEMBL223855 exhibiting the highest affinity. ADMET analysis highlighted CHEMBL223855 as a promising candidate for drug development, boasting favorable properties, including high gastrointestinal absorption and absence of blood-brain barrier permeation. Despite medicinal chemistry alerts and lead likeness violations, this comprehensive analysis guides future experimental validation efforts, supporting the potential of these catechins as effective catalase modulators.
  • Computational Identification of Methionyl-tRNA-Synthetase Inhibitors for Brucella melitensis: A Hybrid of Ligand-based Classic 3-Point Pharmacophore Screening and Structure Cavity Guided Blind Docking Approach
    Sumit Deore, Ramanlal Kachave, Pranjal Gholap, Kiran Mahajan, Harshal Tare
    International Journal of Pharmaceutical Quality Assurance, 2023
    This study employs a hybrid computational approach to identify potential methionyl-tRNA synthetase inhibitors for Brucella melitensis. Utilizing ligand-based pharmacophore screening and structure-based blind docking, we selected a lead compound, CHEMBL349379, from the ChEMBL 2D database. Docking simulations revealed high binding affinity and favorable interactions. Lead optimization using ADMETlab 2.0 demonstrated promising drug-like properties, but a detailed toxicity analysis highlighted concerns. Experimental validation is needed to confirm inhibitory potential and address toxicity issues. This approach streamlines the identification of potential therapeutic agents for B. melitensis treatment.
  • Design and Discovery of Genistein-based Drugs as a Potential Tyrosine Kinase Inhibitor for Lung Adenocarcinoma through Hybrid In-silico Methods
    Vijay Wakale, Ramanlal Kachave, Pranjal Gholap, Kiran Mahajan, Harshal Tare
    International Journal of Drug Delivery Technology, 2023
  • Eriodictyol Flavanones Based Virtual Screening of Bioactive Compounds from ChEMBL 2D Database with Classic 3-point Pharmacophore Screening Method for HER2 Inhibitors for Breast Cancer
    Harshal Tare, Anjali Bedse, Ujjwala Thube, Ramanlal Kachave, Vijay Wagh
    International Journal of Drug Delivery Technology, 2023
  • In-silico Design and Development of Multi-Target Agents Targeting Glycogen Synthase Kinase-3 Beta and Vascular Endothelial Growth Factor Receptor 2 for Acute Myeloid Leukemia
    Asmita Gaikwad, Nandu Kayande, Harshal Tare, Babaso Udugade, Ramanlal Kachave
    International Journal of Drug Delivery Technology, 2023
  • Exploring Film Forming Ability of Newly Synthesized Rosin Esters
    Pramod Burakale, Suresh Sudke, Manish Bhise, Harshal Tare, Ramanlal Kachave
    International Journal of Drug Delivery Technology, 2023
  • Formulation and Evaluation of Herbal Remedy for Cough
    Anjali Bedse, Ashwini Nalawade, Suchita Dhamane, Ramanlal Kachave, Vijay Wagh, et al.
    International Journal of Pharmaceutical Quality Assurance, 2023
  • Spectroscopic and Chromatographic Estimation of Some Sartans and their Combinations with Thiazide Diuretics: A Review
    Kajal P. Baviskar, Ramanlal N. Kachave
    Current Pharmaceutical Analysis, 2023
  • Importance of functional foods in the management of autism
    Sweta Rai, Raj K. Keservani, Prashant Kumar, Vikrant Kisanrao Nikam, Ramanlal N. Kachave, et al.
    Nutraceutical Fruits and Foods for Neurodegenerative Disorders, 2023
  • Preclinical evaluation of the diabetic wound healing activity of phytoconstituents extracted from Ficus racemosa Linn. leaves
    Sadhana Pawar, Kajal Pawade, Sonali Nipate, Aishawarya Balap, Bhushan Pimple, et al.
    International Journal of Experimental Research and Review, 2023
  • Overview of UHPLC-MS: an Effective and Sensitive Hyphenated Technique
    Vaishnavi A. Sarangdhar, Ramanlal N. Kachave
    Journal of Analytical Chemistry, 2022
  • A Review: Recent Analytical Applications on Anti-epileptic Agents
    Ramanlal N. Kachave, Reshma N. Shelke, Manoj V. Mahale
    Current Pharmaceutical Analysis, 2022
  • Development and Validation of Bioanalytical Method for Determination of Nebivolol and Valsartan in Human Plasma by Using RP-HPLC
    R. N. Kachave, A. G. Mundhe
    European Pharmaceutical Journal, 2021
  • A review on analytical methods of antigout agents
    RamanlalN Kachave, PragatiB Mandlik, SnehalR Wakchaure
    Journal of Reports in Pharmaceutical Sciences, 2020
  • Liquid chromatography method development and validation of related impurities of lurasidone and its formulation
    Indian Drugs, 2018
  • Recent trends in impurity profiling and forced degradation of antihypertensive drugs
    Megha N. Salunkhe, Snehal D. Gite, Ramanlal N. Kachave
    Journal of Liquid Chromatography and Related Technologies, 2017
  • Simultaneous estimation of cilnidipine and Valsartan by RP-HPLC in tablet formulation
    Ramanlal Kachave, Mayura Kale, Rajendra Wagh
    Eurasian Journal of Analytical Chemistry, 2016

Publications

1. Ramanlal N. Kachave et al. Impurity Profiling and Forced Degradation Study of Angiotensin (AT1) Blockers: A Review. Analytical Science Springer. Communicated (
2. Ramanlal N. Kachave et al. Bioanalytical Method Development and Validation of Isosorbide Mononitrate in human plasma by using LC-MS/MS. Journal of Analytical Chemistry. Springer. Communicated (
3. Ramanlal N. Kachave et al. Development and Validation of Stability-Indicating RP-HPLC method for Azilsartan Medoxomil. Beni-Suef University Journal of Basic and Applied Sciences Springer. Communicated
4. Ramanlal N. Kachave et al. Overview of UHPLC-MS: An effective and sensitive hyphenated technique. Journal of Analytical Chemistry Springer Nature. Accepted (
5. Ramanlal N. Kachave et al. A Review: Recent Analytical Applications on Anti-Epileptic Agents. Current Pharmaceutical Analysis, Bentham Sciences. Accepted (
6. Ramanlal N. Kachave et al. Bioanalytical method development and validation of cilnidipine and metoprolol succinate by RP-HPLC: Its pharmacokinetics application. Current Chinese Chemistry, Bentham Science, 2(1), 2022, 59-64. DOI: 10.2174/22106766116662106142035.
7. Ramanlal N. Kachave et al. Stability indicating assay method for determination of Febuxostat by RP-HPLC. Current Chinese Chemistry, Bentham Science 2(1), 2022, 50-58. DOI:10.2174/2666001601666210427114547.
8. Ramanlal N. Kachave et al. Bioanalytical Method Development and Validation of Nebivolol and Valsart

GRANT DETAILS

MODROB Research Grant from AICTE, New Delhi
 Year 2019-2022 (,
Successfully receiving the research grants from BCUD Savitribai Phule Pune University, Pune
 Year 2016-18 (Rs.1, 40,000/-)
 Year 2011-13 (Rs.1, 60,000/-)