Dr. Suyog N. Korade

@unichemlabs.com

Research executive, Process Research department, Centre of Excellence,
Unichem Laboratories Ltd.



           

https://researchid.co/chemsuyog

EDUCATION

M.Sc., SET, Ph.D. (Organic Chemistry)

13

Scopus Publications

Scopus Publications

  • Meglumine catalyzed one pot synthesis of new fluorescent 2-amino-4-pyrazolyl-6-aryldiazenyl-4H-chromene-3-carbonitriles
    Suyog N. Korade, Pradeep M. Mhaldar, Prafulladatta P. Kulkarni, Gajanan S. Rashinkar, and Dattaprasad M. Pore
    Informa UK Limited
    Abstract Meglumine, a biodegradable basic organo-catalyst has been efficiently explored for the one-pot synthesis of new fluorescent 2-amino-4-(5-hydroxy-3-methyl-1H-pyrazol-4-yl)-6-aryldiazenyl-4H-chromene-3-carbonitriles in an aqueous medium at room temperature. The synthesized compounds were found highly fluorescent when screened for photoluminescence properties. The planar structure equipped with substituted aryldiazenyl group led to the extension of conjugation that facilitated fluorescence emission in the visible region with a large stokes shift of 290–294 nm. The novelty of work is a synthesis of highly conjugated molecular assembly, high yield in shorter reaction time, energy efficiency, atom economy, utilization of water as a universal green solvent and meglumine as an eco-benign organo-catalyst. Graphical Abstract

  • Synthesis and Biological Activities of Novel Aryldiazo Substituted Heterocycles
    Suyog N. Korade, Jayavant D. Patil, Deepak S. Gaikwad, Suraj A. Sonawane, Sandip P. Vibhute, Nilam C. Dige, Pradeep M. Mhaldar, and Dattaprasad M. Pore
    Informa UK Limited
    Interestingly, in some examples of bioactive heterocycles, a more pronounced effect is observed when two or more different heterocyclic moieties are incorporated within a single molecule. In this context, recent attention is focused on construction of structures with multiple heterocycles, as well as on the creation of heterocyclic diversity from common precursors. The benzopyran motif, for example, plays a vital role in pharmaceutical chemistry. The benzopyran core is considered to be responsible for most of significant biological activities such as Epicalyxin F exhibiting antiproliferative activity against HT-1080 fibrosarcoma and colon 26-L5 carcinoma, tetrahydrocannabinol possessing an agonistic effect on cannabinoid receptors, CB 1 and CB 2, and rhododaurichromanic acid A showing phytotoxic properties. Other valuable heterocycles, such as xanthenes and 5-deaza-10-oxaflavins also incorporate the benzopyran skeleton. In particular, 1-oxo-hexahydroxanthenes have such pharmacological properties as antibacterial, antiestrogenic, antithrombin and hypoglycemic activities. Like xanthenes, 5-deaza-10oxaflavins have received strong attention from organic chemists. They have been employed as intermediates for the preparation of other heterocycles as well as acting as selective organic oxidants under mild conditions. Moreover, they are known to display bioactivity as drugs. Such compounds have long been of interest because of their unique photochemical and photophysical properties. But they are also well known for their medicinal significance. Notably, they play a vital role in biological reactions such as the inhibition of DNA, RNA, carcinogenesis, protein synthesis and nitrogen fixation. Interestingly, some arylazo compounds are found to exhibit anti-HIV, anti-inflammatory and cytoprotective activities (Figure 1). In our own work, we hypothesized that, if benzopyran fused heterocycles were merged together with aryldiazo groups, the resulting molecular scaffolds might possess enhanced bioactivity. In continuation of our interest in ionic liquid catalyzed organic transformations, we report herein the synthesis of 1-oxo-hexahydroxanthenes, 5-deaza-10-oxaflavins, 2,3-dihydroquinazolin-4(1H)-ones and 1,2,4-triazolidine-3-thiones incorporating aryldiazo groups. This was accomplished using catalysis by the ionic


  • Synthesis of magnetically separable catalyst Cu-ACP-Am-Fe<inf>3</inf>O<inf>4</inf>@SiO<inf>2</inf> for Huisgen 1,3-dipolar cycloaddition
    S.P. Vibhute, P.M. Mhaldar, S.N. Korade, D.S. Gaikwad, R.V. Shejawal, and D.M. Pore
    Elsevier BV

  • Choice of Solvent in the Synthesis of Chromeno[3,4-c]pyridines and Chromene-3-carboxylates
    Mansing M. Mane, Suyog N. Korade, Sarika M. Chinchkar, and Dattaprasad M. Pore
    Informa UK Limited
    A variety of condensation procedures have been used for the synthesis of chromenopyridine derivatives. Marta Costa reported a two component method for synthesis of 4amino-2-hydroxy-5-methylidene-5H-chromeno [3,4-c]pyridine-1-carbonitriles (4) from 2-oxo-2H-1-benzopyran-3-carbonitrile and cyanoacetamide in the presence of triethylamine, which were active at adenosine receptors. O’Callaghan and co-workers carried out the same reaction in presence of ammonium acetate. However, they observed formation of a different class of chromenopyridines by a ring opening mechanism. (Scheme 1). Although adenosine receptors 4 could be obtained by the former method, the yield was low (26–35%). To improve the yield, an efficient multi-component strategy is essential. The method presented in this study allows the synthesis of 4 from salicylaldehyde, ethyl cyanoacetate and ammonium acetate (Scheme 1). The multi-component reaction of salicylaldehyde, cyano ethylacetate and ammonium acetate in ethanol under reflux condition formed the expected product 4 in good yield. When the reaction was carried out in water at reflux, unexpected formation of ethyl-2-amino-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate (5) was observed (Scheme 1). This finding may be due to the affinity of the –CN group towards hydrogen bonding in water, increasing the electrophilicity of –CN. In either solvent, isolation of the product was carried out by simple filtration. The H NMR (DMSO-d6) spectrum of 4a (Table 1, entry 1) exhibited two singlets at d 8.98 ppm and d 8.39 (broad) ppm corresponding to –NH and –NH2 protons, respectively. In case of 5a, the presence of notable doublets at d 4.33 and 4.54 ppm with coupling constant 3.6Hz indicates the presence of a benzylic proton and methine proton, respectively. The C NMR spectrum of 4a depicted a signal at d 169 ppm indicate the presence of only one carbonyl carbon, while signals at d 80.60 and 86.64 ppm are due to the sp carbons of pyridine bearing –NH2 and –CN groups, respectively. In case of


  • Ester functionalized hydrophobic task specific ionic liquid for Glaser coupling


  • In-situ-generated palladium nanoparticles in novel ionic liquid: an efficient catalytic system for Heck–Matsuda coupling
    D. S. Gaikwad, K. A. Undale, D. B. Patil, D. M. Pore, S. N. Korade, and A. A. Kamble
    Springer Science and Business Media LLC

  • DABCO: An efficient catalyst for pseudo multi-component reaction of cyclic Ketone, Aldehyde and Malononitrile
    Sarika M. Chinchkar, Jayavant D. Patil, Suyog N. Korade, Gavisiddappa S. Gokavi, Rajendra V. Shejawal, and Dattaprasad M. Pore
    Bentham Science Publishers Ltd.

  • Novel task-specific ionic liquid for room temperature synthesis of spiro-1,2,4-triazolidine-3-thiones
    Suyog N. Korade, Jayavant D. Patil, and Dattaprasad M. Pore
    Springer Science and Business Media LLC

  • An efficient synthesis of anti-microbial 1,2,4-triazole-3-thiones promoted by acidic ionic liquid
    Pradeep B. Patil, Jayavant D. Patil, Suyog N. Korade, Siddheshwar D. Kshirsagar, Sanjay P. Govindwar, and Dattaprasad M. Pore
    Springer Science and Business Media LLC

  • Dual functionalized task specific ionic liquid promoted in situ generation of palladium nanoparticles in water: synergic catalytic system for Suzuki-Miyaura cross coupling
    Jayavant D. Patil, Suyog N. Korade, Supriya A. Patil, Dipak S. Gaikwad, and Dattaprasad M. Pore
    Royal Society of Chemistry (RSC)
    A new task specific ionic liquid with hydroxyl and prolinate functionalities acts as a reducing agent and serves as a ligand and stabilizer for in situ formed palladium nanoparticles. This system displays high catalytic activity for Suzuki–Miyaura cross-coupling in water.

  • 1,1′-Sulfinyldipyridinium bis (hydrogen sulfate) ionic liquid: Synthesis and application in the temperature-influenced synthesis of novel pyranopyrimidinediones and pyranopyrimidinetriones
    Jayavant D. Patil, Suyog N. Korade, and Dattaprasad M. Pore
    Royal Society of Chemistry (RSC)
    A novel and robust dication Brønsted acidic ionic liquid as a catalyst for the temperature influenced synthesis of novel pyranopyrimidinediones and pyranopyrimidinetriones.