Dr. Sheshagiri Dixit

Scopus Publications

In silico design, chemistry and biological activity of thiazole-based azetidinone Schiff bases as potential anti-Alzheimer agents
Sindhu Thattil Johny, Jainey Puthenveetil James, Zakiya Fathima Cherangai, Rajalakshimi Vasudevan, Venugopal Shri Vidya, Sheshagiri Dixit, Saravanan Parameswaran
Journal of Computer Aided Molecular Design, 2026
Riboflavin and Thymine from Abutilon indicum Linn. Mitigate Allergic Responses: An Integrated network pharmacology, In-silico analysis, MD Simulation, In vitro and Ex vivo Studies
B. C. Mamatha, Sharfuddin Mohd, Vancha Harish, Ashwini Prabhu, Durgesh Paresh Bidye, Sheshagiri R. Dixit, B. C. Revanasiddappa, Aravinda Pai, Shareef Shaik
Journal of Computational Biophysics and Chemistry, 2026
Abutilon indicum Linn., commonly known as Indian mallow, is known for its diverse pharmacological properties. This study investigates the anti-allergic and protective effects of hydro alcoholic extract of A. indicum (HAEAI) and two bioactive compounds, riboflavin and thymine, from A. indicum, using both in vitro and in vivo models. Cytotoxicity of these molecules was evaluated through the MTT assay on RBL-2H3 cells. Additionally, their anti-allergic effects were assessed using an ex vivo study, evaluating mast cell degranulation induced by Compound 48/80 in rat mesentery and the percentage protection of mast cells was quantified. Ionomycin was used to stimulate RBL-2H3 cells and mediator release. The degranulation levels of the compounds were assessed using the [Formula: see text]-hexosaminidase and histamine release assay. Additionally, the expression levels of cytokines, including TNF-[Formula: see text], IL-4, IL-6 and IL-13, were quantified using ELISA. The network consisting of composition, targets, and disease has been established. Gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses were performed. Molecular docking techniques were used to simulate the binding affinity of active compounds to target proteins, while molecular dynamics were applied to validate the results obtained from the molecular docking. Riboflavin, Thymine and extract were found to be non-toxic on RBL-2H3 cells. Results demonstrated inhibition of the allergic response induced by Ionomycin. Hence, these two compounds present in Abutilon indicum Linn., emerged as potential drug candidates and can be used in the management of allergic conditions.
Novel heterocyclic hybrids of Thiophene clubbed 1,3,4-oxadiazoles targeting dihydrofolate reductase (DHFR): An in silico approach, molecular docking, ADMET studies, MM-GBSA assay and MD simulations
S. Prasanth, B.C. Revanasiddappa, Venkatesh Ranjan, Durgesh Paresh Bidye, Sheshagiri R. Dixit
Biophysical Chemistry, 2026
Anti-Allergic and Cytotoxic Properties of Abutilon indicum Linn. Extract and Its Phytochemical Constituents: By Ex Vivo, In Vitro Models, and In Silico Analysis
Mamatha B. C., Revanasiddappa B. C., Vijaya Kumar S., Nanditha Bhat, Ashwini Prabhu, Durgesh Paresh Bidye, Sheshagiri R. Dixit, Aravinda Pai, Kuntal Bose
Chemistry and Biodiversity, 2026
Abutilon indicum Linn., a shrub belonging to the Malvaceae family, was investigated for its cytotoxicity and anti‐allergic properties. This study evaluated the effects of the hydroalcoholic extract of A. indicum (HAEAI) and its phytomolecules using various experimental and computational approaches. The cytotoxicity of the HAEAI and its phytomolecules, namely, syringaldehyde (SYD), methyl coumarate (MC), and methyl‐3‐indole carboxylate (M3IC), was assessed at different concentrations using the MTT assay on rat basophilic leukemia (RBL‐2H3) cells. Ionomycin was employed to stimulate RBL‐2H3 cells and mediate allergic responses. Degranulation levels were determined using β‐hexosaminidase and histamine release assays, whereas cytokine expression (IL‐4, TNF‐α, IL‐6, and IL‐13) was quantified. GC–MS analysis of the HAEAI identified a wide range of phytomolecules. Plant extract (HAEAI) and phytomolecules were further evaluated using Compound 48/80‐induced mast cell degranulation in rat mesentery ex vivo. Compound 48/80 activated mast cells to mediate allergic reactions, and the percentage protection was calculated by counting intact and degranulated mast cells. In silico studies, including molecular docking, ADMET predictions, and toxicity assessments, were performed to evaluate the phytomolecules. Molecular docking revealed that M3IC exhibited a superior glide score (−6.060 kcal/mol) compared to the standard disodium cromoglycate (DSG, −5.483 kcal/mol). The phytomolecules were predicted to be nontoxic with respect to mutagenicity, irritation, and reproductive toxicity. Cytotoxicity results indicated that HAEAI and its phytomolecules (SYD, MC, and M3IC) were cyto‐proliferative and nontoxic in RBL‐2H3 cells. The positive control, ionomycin, showed 43.34% ± 0.21% cytotoxicity at 7.47 µg/mL, whereas the standard compound DSG was found to be cell‐proliferative and nontoxic at 25.61 µg/mL. Both A. indicum L. extract (HAEAI) and its phytomolecules effectively inhibited ionomycin‐induced allergic responses, as evidenced by reduced β‐hexosaminidase and histamine release, decreased pro‐inflammatory cytokines (IL‐4, TNF‐α), and increased anti‐inflammatory cytokines (IL‐6 and IL‐13). SYD, MC, and M3IC were shown to alleviate ionomycin‐induced allergic symptoms, emerging as potential drug candidates for the management of allergic conditions.
MD Simulations, DFT and Molecular Docking Studies of Schiff Base–Derived Heterocycles as Potent BuChE Inhibitors for Alzheimer's Disease
Sindhu T. J., Jainey P. James, Zakiya Fathima C., Sheshagiri Dixit, Krishna Yallappa Kolachi
Chemistryselect, 2026
Butyrylcholinesterase (BuChE) must be considered a critical target for effective Alzheimer's disease (AD) therapy. This investigation utilises in silico techniques to assess the cholinesterase inhibition profiles of a series of 32 Schiff base–derived azetidinone heterocycles. The program Schrödinger was used to perform in silico procedures, including docking, MMGBSA, molecular dynamics (MD) simulation and pharmacophore modelling investigations. Compounds A28, A26 and A27 exhibited exceptional docking scores against butyrylcholinesterase, and MMGBSA calculations assessed further binding energy. Meanwhile, the stability of the A28, A26 and A27 complexes with 6SAM was evaluated through MD simulations, which confirmed that the A28_6SAM complex exhibited greater stability than the others, thereby supporting the overall stability of the ligand–target interactions. According to the highest occupied molecular orbital (HOMO) and lowest unoccupied molecular orbital (LUMO) energies, compound A28 was determined to be electrically stable in density functional theory (DFT) investigations. Analysis of pharmacophore modelling revealed structural elements necessary for inhibition. These results demonstrate the potential of azetidinone heterocycles as potent butyrylcholinesterase inhibitors. All compounds were predicted to have anti‐Alzheimer potential using the prediction of activity spectra for substances (PASS) algorithm. After evaluating additional expected targets for A28, reverse docking with these newly anticipated targets was also done for confirmation. These findings underscore the utility of in silico methodologies in the rational design and identification of novel butyrylcholinesterase inhibitors as prospective healing agents for AD.
Pyrimidine-Based Compounds in Tuberculosis Management: A Review of their Biological and Medicinal Importance
Deepshikha Singh, Vikram Singh, Afrasim Moin, Manu Gangadhar, Bistuvalli Chandrashekarappa Revanasiddappa, Sheshagiri R. Dixit
Medicinal Chemistry, 2026
Pyrimidine derivatives are a class of chemically and biologically active heterocyclic compounds promising for developing anti-tubercular, anti-viral, anti-malarial, anti-inflammatory, and enzyme-inhibiting drugs. To cure TB, scientists were driven to establish novel pyrimidine derivatives. The main objective of the current review is to identify and develop new pyrimidine moiety- containing derivatives that have been assessed for their structure-activity relationship (SAR). Several drug-resistant MTB infections have emerged and spread worldwide, which has rendered first-line medication ineffective. It is crucial to develop new anti-TB drugs that are extremely effective against both drug-sensitive and drug-resistant TB. The development of pyrimidine therapeutic methods will thus benefit from the current review. Three medications-GSK-286, TBA-7371, and SPR-720 are now undergoing clinical testing. This study aims to emphasize the structural variety of anti-tuberculosis pyrimidine-containing compounds by providing an overview of current developments in drug discovery investigations.
Analytical and Bioanalytical Advances in Oxazolidinones: A Critical Review of Methods, Stability, and Clinical Translation
Manasa Chittipolu, Erica Alves, Savita Umarani, Ajaykumar Chittipolu, P. Pattaluchetty, H. R. Rashmi, R. S. Chandan, Sheshagiri R. Dixit, Riyaz Ali M. Osmani, Gundawar Ravi, Amarjitsing Rajput
Critical Reviews in Analytical Chemistry, 2026
Oxazolidinones remain pivotal in treating multidrug-resistant infections, yet analytical and bioanalytical methodologies supporting their development and clinical use remain uneven across the class. This critical review consolidates recent advances spanning formulation quality control to therapeutic drug monitoring (TDM), offering an integrated cross-platform comparison of how analytical and bioanalytical methodologies shape oxazolidinone readiness for precision antimicrobial therapy. Analytical methods-from spectrophotometry and HPLC to LC-MS/MS-have progressed toward stability-indicating workflows, impurity profiling, and regulatory alignment, with emerging but inconsistent adoption of Quality by Design (QbD) and Green Analytical Chemistry (GAC). Bioanalytical approaches, dominated by LC-MS/MS with evolving micro-sampling and matrix-adapted extractions, have enabled pharmacokinetic characterization, exposure-response evaluation, and patient-specific dose optimization. Together, these methodologies reveal a functional divide: analytical assays secure drug identity and formulation robustness, whereas bioanalytical tools translate oxazolidinones into clinical decision systems. However, major gaps persist, including limited characterization of newer investigational analogues, poor harmonization across matrices and laboratories, and underutilization of computational, mechanistic, and eco-sustainable strategies. Bridging these gaps requires integrated, standardized, and patient-centered analytical frameworks to ensure that both established and emerging oxazolidinones remain effective in the era of escalating antimicrobial resistance.
Novel in silico Evidence of Bisphenol A as a Neuroinflammatory Modulator through the cGAS-STING-NLRP3 Pathway
Veena V Tom, Sheshagiri Dixit, Karthik Pujar, Athira Sasidharan, Deepthi K, Zakiya Fathima C, Yogish Somayaji, Ronald Fernandes
Neurotoxicity Research, 2025
Pyrazine Linked 1,3,4-Oxadiazoles as DNA Gyrase Inhibitors: In silico Design, Molecular Docking, MM-GBSA Assay, MD Simulations and ADMET Studies
Venkatesh Ranjan, B. C. Revanasiddappa, S. Prasanth, Nanditha Bhat, Durgesh Paresh Bidye, Sheshagiri R. Dixit, Aravinda Pai
Journal of Computational Biophysics and Chemistry, 2025
The recent surge in multi-drug-resistant organisms has led to millions of infections and deaths worldwide, highlighting the urgent need for novel antimicrobial agents. In response, this study aims to investigate the designed hybrid molecules of 1,3,4-oxadiazole-pyrazine derivatives (P1–15) and to assess their potential as DNA gyrase inhibitors through in silico approach. All the designed compounds were in compliance with Lipinski’s rule for drug-likeness, ADMET profile. Further molecular docking studies revealed that compounds P1 ([Formula: see text] kcal/mol), P2 ([Formula: see text] kcal/mol), demonstrated superior binding affinities, surpassing standard drug Novobiocin ([Formula: see text] kcal/mol). The calculations related to MM-GBSA showed favorable free binding energy. A 200 ns MD simulations for P1 and standard Novobiocin were conducted to identify the key interactions occurring within the protein–ligand complexes. Based on these results, this study indicates that these compounds can be utilized to develop new antimicrobial agents by incorporating preferred structural modifications.
Structure-based design, synthesis, computational screening and biological evaluation of novel pyrrole fused pyrimidine derivatives targeting InhA enzyme
Deepshikha Singh, Praveen M. Parkali, Umme Hani, Riyaz Ali M. Osmani, Nazima Haider, Jyothi Kumari, Dharmarajan Sriram, Christian Lherbet, B. C. Revan Siddappa, Sheshagiri R. Dixit
Rsc Advances, 2025
In this study, a series of 12 novel pyrrolyl chalcones and 22 pyrrole-fused pyrimidine derivatives were synthesized with good yields.
MOLECULAR DOCKING AND DYNAMIC SIMULATION ON PLA2, NIK, COX-2, AND IRAK-4 INHIBITORS AS ANTIPHLOGISTIC AGENTS IN ZINGIBER OFFICINALIS
CHAYA H., CHAYA P. L., AKSHATHA MUDIGERE, JANE B. MATHEW, ZAKIYA FATHIMA, DURGESH PARESH BIDYE, SHESHAGIRI DIXIT
International Journal of Applied Pharmaceutics, 2025
Design, Synthesis, and Anti-Alzheimer Activity of 2,5-Disubstituted 1,3,4-Thiadiazole: Kinetic Studies, Molecular Docking, and MD Simulations
M. L. Sujatha, Prabhu Jalihal, Manjunatha S. Katagi, Durgesh Paresh Bidye, Sheshagiri R. Dixit, B. P. Nandeshwarappa
Russian Journal of Bioorganic Chemistry, 2025
IN SILICO EVALUATION OF CSF1R INHIBITORS: A PROMISING APPROACH FOR TARGETING NEUROINFLAMMATION IN NEURODEGENERATIVE DISEASES
ATHIRA SASIDHARAN, DEEPTHI K., SHESHAGIRI DIXIT, DEEPSHIKHA SINGH, VEENA V. TOM, YOGISH SOMAYAJI, RONALD FERNANDES
International Journal of Applied Pharmaceutics, 2025
Benzothiazole derivatives as p53-MDM2 inhibitors: in-silico design, ADMET predictions, molecular docking, MM-GBSA Assay, MD simulations studies
Shridhar Deshpande N, Shivakumar, Udaya Kumar D., Sudeep D. Ghate, Sheshagiri R. Dixit, Abhimanyu Awasthi, B. C. Revanasiddappa
Journal of Biomolecular Structure and Dynamics, 2025
Quinoline Based thiazolidinediones: Design, Synthesis, In Silico, In Vitro, Antioxidant and Antidiabetic Evaluation
Sharfuddin Mohd, Durgesh Paresh Bidye, Sheshagiri R Dixit, B. C. Revanasiddappa, Vancha Harish, Rakesh Kumar, Vikas Sharma
Chemistryselect, 2024
NOVEL HYBRIDS OF QUINOLINE LINKED PYRIMIDINE DERIVATIVES AS CYCLOOXYGENASE INHIBITORS: MOLECULAR DOCKING, ADMET STUDY, AND MD SIMULATION
DEEPTHI K, MANJUNATH S. KATAGI, JENNIFER FERNANDES, SHESHAGIRI DIXIT, DEEPSHIKHA SINGH
International Journal of Applied Pharmaceutics, 2024
Exploring Plant-Derived Bioactive Compounds in Olea Europaea L. Leaves as Potent Inhibitors of PTP-1B Using an In silico Approach
N. Shridhar Deshpande, Shrutesh Wagh, Abhishek Prakash Sharma, Amgoth Ramesh, Mahindra, Lavanya, B. S. Moksha, Divyashree, Disha, Sheshagiri R. Dixit, Deepshikha Singh, Durgesh Paresh Bidye, B. C. Revanasiddappa
Journal of Computational Biophysics and Chemistry, 2024
Synthesis, Molecular Docking, MD Simulation and Evaluation of Anticancer Activity of Novel 1,3,4-Oxadiazole Derivatives against Ehrlich Ascites Carcinoma (EAC) Cell Lines
N. Shridhar Deshpande, Shivakumar, D. Udayakumar, Ashwini Prabhu, Vinitha Rani, Sheshagiri R. Dixit, Deepshikha Singh, B. C. Revanasiddappa
Journal of Computational Biophysics and Chemistry, 2024
Drug targets, current and future therapeutics for the treatment of multi drug resistant tuberculosis with their clinical applications: A critical review
Deepshikha Singh, Vikram Singh, Subhankar P. Mandal, Karen Dsouza, B.R. Prashantha Kumar, Sheshagiri R. Dixit
Current Drug Therapy, 2024
Novel β-L-1,3-thiazolidine pyrimidine nucleoside analogues: Design, synthesis, molecular docking, and anti-HIV activity
Shimoga Nagaraj Sriharsha, N．Habeela Jainab, Mahalakshmi Suresha Biradar, Shankar Thapa, E S Venkatesh, Durgesh Paresh Bidye, Gurubasavaraj Pujar, Sheshagiri Dixit
Journal of Molecular Structure, 2023
A Review on Thiazole derivatives and their impact as hypoglycemic agents in drug developments
Dheeraj Rajesh Gupta, Pankaj Kumar, Abhishek Kumar, Sachin A Kumbar, Vidya Murugeshwari, Seshagiri R Dixit
Research Journal of Pharmacy and Technology, 2023
Anticancer Activity of Anti-Tubercular Compound(s) Designed on Pyrrolyl Benzohydrazine Scaffolds: A Repurposing Study
Turki Al Hagbani, Afrasim Moin, Talib Hussain, N. Vishal Gupta, Farhan Alshammari, Syed Mohd Danish Rizvi, Sheshagiri Dixit
Processes, 2023
Virtual Screening of Alkaloids and Flavonoids as Acetylcholinesterase and MAO-B Inhibitors by Molecular Docking and Dynamic Simulation Studies
Jainey P. James, Pradija Sasidharan, Subhankar P. Mandal, Sheshagiri R. Dixit
Polycyclic Aromatic Compounds, 2023
Design, synthesis and computational approach to study novel pyrrole scaffolds as active inhibitors of enoyl ACP reductase (InhA) and Mycobacterium tuberculosis antagonists
S.R. Prem Kumar, Ibrahim Ahmed Shaikh, Mater H. Mahnashi, Mohammed Abdulrahman Alshahrani, Sheshagiri R. Dixit, Venkatarao H. Kulkarni, Christian Lherbet, Andanappa K. Gadad, Tejraj M. Aminabhavi, Shrinivas D. Joshi
Journal of the Indian Chemical Society, 2022
Identification of benzothiazole-rhodanine derivatives as α-amylase and α-glucosidase inhibitors: Design, synthesis, in silico, and in vitro analysis
Mahendra Gowdru Srinivasa, Natasha Naval Aggarwal, Banylla Felicity Dkhar Gatpoh, Madan Kumar Shankar, Kannika Byadarahalli Ravindranath, Pujar Gurubasavaraj Veeranna, Sheshagiri Dixit, Subhankar P. Mandal, Prashantha Kumar Bommenahally Ravanappa, Pukar Khanal, Revanasiddappa Bistuvalli Chandrashekarappa
Journal of Molecular Recognition, 2022
Valorization of Plastic Waste to Generate Hydrocarbons by Hybrid Pyrolysis
Kesari Gopi Kiran, Sheshagiri Dixit, Kalya Tulasidas Vadiraj
Environmental Engineering Science, 2022
Comparative Investigation on the Crystal Structures, Hirshfeld Surface Analysis, Antitubercular Assays, and Molecular Docking of Regioisomeric 1,2,3-Triazoles
Ashish Anand, Kishorkumar Sindogi, Sheshagiri R. Dixit, Richa P. Shetty, Gurubasavaraj V. Pujar, Manohar V. Kulkarni, Tayur N. Guru Row
Chemistryselect, 2022
Isolation and characterization of ACE-I inhibitory peptides from ribbonfish for a potential inhibitor of the main protease of SARS-CoV-2: An in silico analysis
Undiganalu G. Yathisha, Mahendra Gowdru Srinivasa, Revana Siddappa BC, Subankar Mandal, Sheshagiri R. Dixit, G. V. Pujar, Mamatha Bangera Sheshappa
Proteins Structure Function and Bioinformatics, 2022
Discovery of Rhodanine and Thiazolidinediones as Novel Scaffolds for EGFR Inhibition: Design, Synthesis, Analysis and CoMSIA Studies
Tisa Francis, Sheshagiri R. Dixit, B. R. Prashantha Kumar
Polycyclic Aromatic Compounds, 2022
Molecular Docking and Three‐Dimensional Quantitative Structure–Activity Relationships for Antitubercular Pyrimidine Derivatives
Praveen M. Parkali, A. Shyam Kumar, Pohamba Johanna K, Shilomboleni Prodensia T, Sruthi Turaga, Vinod Shaiva, Gurubasavaraj V. Pujar, Shrinivas D. Joshi, Tejraj M. Aminabhavi, Sheshagiri R. Dixit
Polycyclic Aromatic Compounds, 2022
Structure-based multitargeted molecular docking analysis of pyrazole-condensed heterocyclics against lung cancer
JAINEY P. JAMES, AISWARYA T. C., SNEH PRIYA, DIVYA JYOTHI, SHESHAGIRI R. DIXIT
International Journal of Applied Pharmaceutics, 2021
Identifying the most potent dual-targeting compound(S) against 3clprotease and NSP15exonuclease of SARS-CoV-2 from nigella sativa: Virtual screening via physicochemical properties, docking and dynamic simulation analysis
Syed Mohd Danish Rizvi, Talib Hussain, Afrasim Moin, Sheshagiri R. Dixit, Subhankar P. Mandal, Mohd Adnan, Qazi Mohammad Sajid Jamal, Dinesh C. Sharma, Abulrahman Sattam Alanazi, Rahamat Unissa
Processes, 2021
Synthesis and in vitro cytotoxicity study of novel 4-substituted quinazolines encompassed with thiazolidinone and azetidinone
Akash Jori, Sheshagiri R. Dixit, Gurubasavraj V. Pujar
Asian Journal of Chemistry, 2020
Development and optimization of dual drug-loaded nanoparticles for the potent anticancer effect on renal carcinoma
Mahmoud S. Soliman, Afrasim Moin, Talib Hussain, D.V. Gowda, Sheshagiri R. Dixit, Amr S. Abu Lila
Journal of Drug Delivery Science and Technology, 2020
Isolation, characterization, and cytotoxic studies of secondary metabolites from the leaves of Bauhinia foveolata Dalzell: An endemic tree from the Western Ghats, India
P. Habbu, N. Miskin, V. Kulkarni, P. Bhat, A. Joshi, A. Bhandarkar, Satish, Kulkarni, S. Dixit, Jaishree Vaijanathappa
Journal of Applied Pharmaceutical Science, 2020
Molecular docking, antiproliferative and anticonvulsant activities of swertiamarin isolated from Enicostemma axillare
Jaishree Vaijanathappa, Jamuna Puttaswamygowda, Ramesh Bevanhalli, Sheshagiri Dixit, Prabitha Prabhakaran
Bioorganic Chemistry, 2020
Synthesis and molecular docking studies of coumarin-imidazole conjugates as potential antimicrobial agents
Indian Journal of Chemistry Section B Organic and Medicinal Chemistry, 2020
Synthesis, molecular modeling and BACE-1 inhibitory study of tetrahydrobenzo[b] pyran derivatives
Vijaya Bhaskar, Reshma Chowdary, Sheshagiri R. Dixit, Shrinivas D. Joshi
Bioorganic Chemistry, 2019
Pharmacophore mapping, molecular docking, chemical synthesis of some novel pyrrolyl benzamide derivatives and evaluation of their inhibitory activity against enoyl-ACP reductase (InhA) and Mycobacterium tuberculosis
Shrinivas D. Joshi, Sheshagiri R. Dixit, Jeelan Basha, V.H. Kulkarni, Tejraj M. Aminabhavi, Mallikarjuna N. Nadagouda, Christian Lherbet
Bioorganic Chemistry, 2018
Green synthesis of coumarin-pyrazolone hybrids: In vitro anticancer and anti-inflammatory activities and their computational study on COX-2 enzyme
Rashmi C. Kulkarni, Jyoti M. Madar, Samundeeswari L. Shastri, Farzanabi Shaikh, Nirmala S. Naik, Ravindra B. Chougale, Lokesh A. Shastri, Shrinivas D. Joshi, Sheshagiri R. Dixit, Vinay A. Sunagar
Chemical Data Collections, 2018
Synthesis and antitubercular activity of some N'-substituted benzoyl-4-(2,5dimethyl-1H-pyrrolyl) benzohydrazide Derivatives
Indian Journal of Heterocyclic Chemistry, 2018
Design and synthesis of coumarin–imidazole hybrid and phenyl-imidazoloacrylates as potent antimicrobial and antiinflammatory agents
Megharaja Holiyachi, S. Samundeeswari, Bahubali M. Chougala, Nirmala S. Naik, Jyoti Madar, Lokesh A. Shastri, Shrinivas D. Joshi, Sheshagiri R. Dixit, Suneel Dodamani, Sunil Jalalpure, Vinay A. Sunagar
Monatshefte Fur Chemie, 2018
Design, Docking, and Synthesis of Quinoline-2H-1,2,4-triazol-3(4H)-ones as Potent Anticancer and Antitubercular Agents
Shilpa M. Somagond, Ravindra R. Kamble, Pramod P. Kattimani, Saba Kauser J. Shaikh, Sheshagiri R. Dixit, Shrinivas D. Joshi, Hirihalli C. Devarajegowda
Chemistryselect, 2018
Synthesis and in vitro anticancer activity of 6-chloro-7-methyl-5H-[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-one derivatives: molecular docking and interaction with bovine serum albumin
Supreet Gaonkar, Manjunath G. Sunagar, Narahari Deshapande, Ningaraddi S. Belavagi, Shrinivas D Joshi, Sheshagiri R Dixit, Imtiyaz Ahmed M. Khazi
Journal of Taibah University for Science, 2018
Green, unexpected synthesis of bis-coumarin derivatives as potent anti-bacterial and anti-inflammatory agents
Bahubali M. Chougala, S. Samundeeswari, Megharaja Holiyachi, Nirmala S. Naik, Lokesh A. Shastri, Suneel Dodamani, Sunil Jalalpure, Sheshagiri R. Dixit, Shrinivas D. Joshi, Vinay A. Sunagar
European Journal of Medicinal Chemistry, 2018
Chemical synthesis and in silico molecular modeling of novel pyrrolyl benzohydrazide derivatives: Their biological evaluation against enoyl ACP reductase (InhA) and Mycobacterium tuberculosis
Shrinivas D. Joshi, Uttam A. More, Sheshagiri R. Dixit, Sunil V. Balmi, Basavaraj G. Kulkarni, Geeta Ullagaddi, Christian Lherbet, Tejraj M. Aminabhavi
Bioorganic Chemistry, 2017
Pyrrolyl pyrazoline carbaldehydes as Enoyl-ACP reductase inhibitors: Design, synthesis and antitubercular activity
Sheshagiri R. Dixit, Shrinivas D. Joshi, Venkatarao H. Kulkarni, Sunil S. Jalalpure, Vijay M. Kumbar, Tulasigiriyappa Y. Mudaraddi, Mallikarjuna N. Nadagouda, Tejraj M. Aminabhavi
Open Medicinal Chemistry Journal, 2017
Design, synthesis, docking and in vitro antifungal study of 1,2,4-Triazole hybrids of 2-(aryloxy)quinolines
Shilpa M. Somagond, Ravindra R. Kamble, Pramod P. Kattimani, Shrinivas D. Joshi, Sheshagiri R. Dixit
Heterocyclic Communications, 2017
Microwave Synthesis of Coumarinyl Substituted Pyridine Derivatives as Potent Anticancer Agents and Molecular Docking Studies
Bahubali M. Chougala, Samundeeswari S, Megharaja Holiyachi, Nirmala S. Naik, Lokesh A. Shastri, Suneel Dodamani, Sunil Jalalpure, Sheshagiri R Dixit, Shrinivas D. Joshi, Vinay A Sunagar
Chemistryselect, 2017
3D-QSAR and molecular docking studies of pyrazole derivatives as inhibitors of Enoyl Acyl carrier protein reductase from Mycobacterium tuberculosis
Sheshagiri Dixit, Shrinivas Joshi, V. Kulkarni, Tejraj Aminabhavi
Letters in Drug Design and Discovery, 2017
Design, synthesis and pharmacological analysis of 5-[4′-(substituted-methyl)[1,1′-biphenyl]-2-yl]-1H-tetrazoles
Atulkumar Kamble, Ravindra Kamble, Suneel Dodamani, Sunil Jalalpure, Vijaykumar Rasal, Mahadev Kumbar, Shrinivas Joshi, Sheshagiri Dixit
Archives of Pharmacal Research, 2017
SYNTHESIS AND ANTITUBERCULAR ACTIVITY OF SOME NOVEL 2,5-DIMETHYL PYRROLYL BENZOHYDRAZIDE DERIVATIVES
Indian Journal of Heterocyclic Chemistry, 2017
Synthesis of new pyrazolyl pyrrole derivatives as antitubercular agents
Indian Journal of Heterocyclic Chemistry, 2017
Novel quinoxalinyl chalcone hybrid scaffolds as enoyl ACP reductase inhibitors: Synthesis, molecular docking and biological evaluation
Vidya Desai, Sulaksha Desai, Sonia Naik Gaonkar, Uddesh Palyekar, Shrinivas D. Joshi, Sheshagiri K. Dixit
Bioorganic and Medicinal Chemistry Letters, 2017
Synthesis, biological evaluation and in silico molecular modeling of pyrrolyl benzohydrazide derivatives as enoyl ACP reductase inhibitors
Shrinivas D. Joshi, Sheshagiri R. Dixit, Venkatarao H. Kulkarni, Christian Lherbet, Mallikarjuna N. Nadagouda, Tejraj M. Aminabhavi
European Journal of Medicinal Chemistry, 2017
Tetrazolylmethyl quinolines: Design, docking studies, synthesis, anticancer and antifungal analyses
Saba Kauser J. Shaikh, Ravindra R. Kamble, Shilpa M. Somagond, H.C. Devarajegowda, Sheshagiri R. Dixit, Shrinivas D. Joshi
European Journal of Medicinal Chemistry, 2017
Transition metal complexes of 2-(2-(1H-benzo[d]imidazol-2-yl)hydrazono)propan-1-ol: Synthesis, characterization, crystal structures and anti-tuberculosis assay with docking studies
Vinayak Kamat, Dhoolesh Kokare, Krishna Naik, Avinash Kotian, S. Naveen, Sheshagiri R. Dixit, N.K. Lokanath, Shrinivas D. Joshi, Vidyanand K. Revankar
Polyhedron, 2017
Synthesis, characterization and molecular docking studies of substituted 4-coumarinylpyrano[2,3-c]pyrazole derivatives as potent antibacterial and anti-inflammatory agents
Bahubali M. Chougala, S. Samundeeswari, Megharaja Holiyachi, Lokesh A. Shastri, Suneel Dodamani, Sunil Jalalpure, Sheshagiri R. Dixit, Shrinivas D. Joshi, Vinay A. Sunagar
European Journal of Medicinal Chemistry, 2017
3,4-Dihydropyrimidinone-coumarin analogues as a new class of selective agent against S. aureus: Synthesis, biological evaluation and molecular modelling study
Nirmala S. Naik, Lokesh A. Shastri, Shrinivas D. Joshi, Sheshagiri R. Dixit, Bahubali M. Chougala, S. Samundeeswari, Megharaj Holiyachi, Farzanabi Shaikh, Jyoti Madar, Rashmi Kulkarni, Vinay Sunagar
Bioorganic and Medicinal Chemistry, 2017
Design and synthesis of novel phenyl -1, 4-beta-carboline-hybrid molecules as potential anticancer agents
S. Samundeeswari, Bahubali Chougala, Megharaja Holiyachi, Lokesh Shastri, Manohar Kulkarni, Suneel Dodamani, Sunil Jalalpur, Shrinivas Joshi, Sheshagiri Dixit, Vinay Sunagar, Ravindra Hunnur
European Journal of Medicinal Chemistry, 2017
Design, docking studies and molecular iodine catalyzed synthesis of benzo[a]xanthen-one derivatives as hyaluronidase inhibitors
Mahadev N. Kumbar, Ravindra R. Kamble, Atulkumar A. Kamble, Shrinivas D. Joshi, Sheshagiri R. Dixit, Joy Hoskeri
Medicinal Chemistry Research, 2016
Synthesis and Human Anticancer Cell Line Studies on Coumarin-β-carboline Hybrids as Possible Antimitotic Agents
S. Samundeeswari, Manohar V. Kulkarni, Shrinivas D. Joshi, Sheshagiri R. Dixit, Srinivasan Jayakumar, R. M. Ezhilarasi
Chemistryselect, 2016
Design, Synthesis and Structure-Activity Relationship Study of Coumarin Benzimidazole Hybrid as Potent Antibacterial and Anticancer Agents
Megharaja Holiyachi, Samundeeswari L. Shastri, Bahubali M. Chougala, Lokesh A. Shastri, Shrinivas D. Joshi, Sheshagiri R. Dixit, Honnappa Nagarajaiah, Vinay A. Sunagar
Chemistryselect, 2016
Drug resistance of antitubercular agents at the genetic level in mycobacterium species: A road map to drug development for counteracting the resistance
Shrinivas D. Joshi, Devendra Kumar, Sheshagiri R. Dixit, Ashwini S. Joshi, Tejraj M. Aminabhavi
Mini Reviews in Organic Chemistry, 2016
Interaction of Hydralazine with Human Serum Albumin and Effect of β-Cyclodextrin on Binding: Insights from Spectroscopic and Molecular Docking Techniques
Mallavva B. Bolattin, Sharanappa T. Nandibewoor, Shrinivas D. Joshi, Sheshagiri R. Dixit, Shivamurti A. Chimatadar
Industrial and Engineering Chemistry Research, 2016
One pot Click chemistry: A three component reaction for the synthesis of 2-mercaptobenzimidazole linked coumarinyl triazoles as anti-tubercular agents
Ashish Anand, Manohar V. Kulkarni, Shrinivas D. Joshi, Sheshagiri R. Dixit
Bioorganic and Medicinal Chemistry Letters, 2016
Synthesis of some novel pyrrolyl hydrazone derivatives as an antitubercular agents
Indian Journal of Heterocyclic Chemistry, 2016
Interaction between carisoprodol and bovine serum albumin and effect of β-cyclodextrin on binding: Insights from molecular docking and spectroscopic techniques
Mallavva B. Bolattin, Sharanappa T. Nandibewoor, Shrinivas D. Joshi, Sheshagiri R. Dixit, Shivamurti A. Chimatadar
Rsc Advances, 2016
Synthesis, characterization and antitubercular activities of novel pyrrolyl hydrazones and their Cu-complexes
Shrinivas D. Joshi, Devendra Kumar, Sheshagiri R. Dixit, Nageshwar Tigadi, Uttam A. More, Christian Lherbet, Tejraj M. Aminabhavi, Kap Seung Yang
European Journal of Medicinal Chemistry, 2016
Synthesis, antimycobacterial screening and ligand-based molecular docking studies on novel pyrrole derivatives bearing pyrazoline, isoxazole and phenyl thiourea moieties
Shrinivas D. Joshi, Sheshagiri R. Dixit, M.N. Kirankumar, Tejraj M. Aminabhavi, K.V.S.N. Raju, Ramanuj Narayan, Christian Lherbet, Kap Seung Yang
European Journal of Medicinal Chemistry, 2016
A click chemistry approach for the synthesis of mono and bis aryloxy linked coumarinyl triazoles as anti-tubercular agents
Ashish Anand, Reshma J. Naik, Hrishikesh M. Revankar, Manohar V. Kulkarni, Sheshagiri R. Dixit, Shrinivas D. Joshi
European Journal of Medicinal Chemistry, 2015
Synthesis and antimicrobial activities of some novel pyrrolyl pyrrolidine derivatives
Indian Journal of Heterocyclic Chemistry, 2015
Synthesis, antimicrobial, analgesic and antiinflammatory activities of some novel pyrrole derivatives
Indian Journal of Heterocyclic Chemistry, 2015
Synthesis, antibacterial and antitubercular activities of novel n1- [2-(substituted phenylamino) acetyl]-4-(1H-pyrrol-1-yl)- benzohydrazide derivatives
Indian Journal of Heterocyclic Chemistry, 2015
3D-QSAR and molecular docking studies of 1,3,4-oxadiazoles containing substituted phenoxy fragment as inhibitors of enoyl-acyl carrier protein reductase from Escherichia coli
Shrinivas D. Joshi, Sheshagiri R. Dixit, Uttam A. More, K. V. S. N. Raju, Ramanuj Narayan, Tejraj M. Aminabhavi, Venkatarao H. Kulkarni
Medicinal Chemistry Research, 2014
Synthesis, characterization, biological activity, and 3D-QSAR studies on some novel class of pyrrole derivatives as antitubercular agents
Shrinivas D. Joshi, Uttam A. More, Sheshagiri R. Dixit, Haresh H. Korat, Tejraj M. Aminabhavi, Aravind M. Badiger
Medicinal Chemistry Research, 2014
Synthesis, antibacterial and antitubercular activities of some novel quinoline derivatives
Indian Journal of Heterocyclic Chemistry, 2014
Synthesis and antitubercular activity of 2-(1H-pyrrol-1-Yl)-5- substituted-1,3,4-oxadiazoles
Indian Journal of Heterocyclic Chemistry, 2014
Enoyl ACP reductase as effective target for the synthesized novel antitubercular drugs: A-state-of-the-art
Shrinivas Joshi, Sheshagiri Dixit, Uttam More, Tejraj Aminabhavi, Venkatrao Kulkarni, Andanappa Gadad
Mini Reviews in Medicinal Chemistry, 2014
IN VTRO ANTIBACTERIAL AND ANTIVIRAL ACTIVITIES OF SOME NOVEL 1,3,4-THIADIAZOLE DERIVATIVES
Indian Journal of Heterocyclic Chemistry, 2012

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