Yovenko Ihor

@onmedu.edu.ua

Department of Anesthesiology, Intensive Care
Odessa National Medical University



              

https://researchid.co/iyovenko
3

Scopus Publications

161

Scholar Citations

2

Scholar h-index

2

Scholar i10-index

Scopus Publications

  • Elective surgery system strengthening: development, measurement, and validation of the surgical preparedness index across 1632 hospitals in 119 countries
    James C Glasbey, Tom EF Abbott, Adesoji Ademuyiwa, Adewale Adisa, Ehab AlAmeer, Sattar Alshryda, Alexis P Arnaud, Brittany Bankhead-Kendall, M K Abou Chaar, Daoud Chaudhry,et al.
    Elsevier BV

  • SARS-CoV-2 infection and venous thromboembolism after surgery: an international prospective cohort study
    , Dmitri Nepogodiev, Joana FF Simoes, Elizabeth Li, Maria Picciochi, James C Glasbey, Glauco Baiocchi, Ruth Blanco‐Colino, Daoud Chaudhry, Ehab AlAmeer,et al.
    Wiley
    SARS‐CoV‐2 has been associated with an increased rate of venous thromboembolism in critically ill patients. Since surgical patients are already at higher risk of venous thromboembolism than general populations, this study aimed to determine if patients with peri‐operative or prior SARS‐CoV‐2 were at further increased risk of venous thromboembolism. We conducted a planned sub‐study and analysis from an international, multicentre, prospective cohort study of elective and emergency patients undergoing surgery during October 2020. Patients from all surgical specialties were included. The primary outcome measure was venous thromboembolism (pulmonary embolism or deep vein thrombosis) within 30 days of surgery. SARS‐CoV‐2 diagnosis was defined as peri‐operative (7 days before to 30 days after surgery); recent (1–6 weeks before surgery); previous (≥7 weeks before surgery); or none. Information on prophylaxis regimens or pre‐operative anti‐coagulation for baseline comorbidities was not available. Postoperative venous thromboembolism rate was 0.5% (666/123,591) in patients without SARS‐CoV‐2; 2.2% (50/2317) in patients with peri‐operative SARS‐CoV‐2; 1.6% (15/953) in patients with recent SARS‐CoV‐2; and 1.0% (11/1148) in patients with previous SARS‐CoV‐2. After adjustment for confounding factors, patients with peri‐operative (adjusted odds ratio 1.5 (95%CI 1.1–2.0)) and recent SARS‐CoV‐2 (1.9 (95%CI 1.2–3.3)) remained at higher risk of venous thromboembolism, with a borderline finding in previous SARS‐CoV‐2 (1.7 (95%CI 0.9–3.0)). Overall, venous thromboembolism was independently associated with 30‐day mortality (5.4 (95%CI 4.3–6.7)). In patients with SARS‐CoV‐2, mortality without venous thromboembolism was 7.4% (319/4342) and with venous thromboembolism was 40.8% (31/76). Patients undergoing surgery with peri‐operative or recent SARS‐CoV‐2 appear to be at increased risk of postoperative venous thromboembolism compared with patients with no history of SARS‐CoV‐2 infection. Optimal venous thromboembolism prophylaxis and treatment are unknown in this cohort of patients, and these data should be interpreted accordingly.

  • Management and outcomes in critically ill nonagenarian versus octogenarian patients
    Raphael Romano Bruno, Bernhard Wernly, Malte Kelm, Ariane Boumendil, Alessandro Morandi, Finn H. Andersen, Antonio Artigas, Stefano Finazzi, Maurizio Cecconi, Steffen Christensen,et al.
    Springer Science and Business Media LLC
    Abstract Background Intensive care unit (ICU) patients age 90 years or older represent a growing subgroup and place a huge financial burden on health care resources despite the benefit being unclear. This leads to ethical problems. The present investigation assessed the differences in outcome between nonagenarian and octogenarian ICU patients. Methods We included 7900 acutely admitted older critically ill patients from two large, multinational studies. The primary outcome was 30-day-mortality, and the secondary outcome was ICU-mortality. Baseline characteristics consisted of frailty assessed by the Clinical Frailty Scale (CFS), ICU-management, and outcomes were compared between octogenarian (80–89.9 years) and nonagenarian (> 90 years) patients. We used multilevel logistic regression to evaluate differences between octogenarians and nonagenarians. Results The nonagenarians were 10% of the entire cohort. They experienced a higher percentage of frailty (58% vs 42%; p < 0.001), but lower SOFA scores at admission (6 + 5 vs. 7 + 6; p < 0.001). ICU-management strategies were different. Octogenarians required higher rates of organ support and nonagenarians received higher rates of life-sustaining treatment limitations (40% vs. 33%; p < 0.001). ICU mortality was comparable (27% vs. 27%; p = 0.973) but a higher 30-day-mortality (45% vs. 40%; p = 0.029) was seen in the nonagenarians. After multivariable adjustment nonagenarians had no significantly increased risk for 30-day-mortality (aOR 1.25 (95% CI 0.90–1.74; p = 0.19)). Conclusion After adjustment for confounders, nonagenarians demonstrated no higher 30-day mortality than octogenarian patients. In this study, being age 90 years or more is no particular risk factor for an adverse outcome. This should be considered– together with illness severity and pre-existing functional capacity - to effectively guide triage decisions. Trial registration NCT03134807 and NCT03370692.

  • Relationship between the Clinical Frailty Scale and short-term mortality in patients ≥ 80 years old acutely admitted to the ICU: a prospective cohort study
    Jakub Fronczek, Kamil Polok, Dylan W. de Lange, Christian Jung, Michael Beil, Andrew Rhodes, Jesper Fjølner, Jacek Górka, Finn H. Andersen, Antonio Artigas,et al.
    Springer Science and Business Media LLC
    Abstract Background The Clinical Frailty Scale (CFS) is frequently used to measure frailty in critically ill adults. There is wide variation in the approach to analysing the relationship between the CFS score and mortality after admission to the ICU. This study aimed to evaluate the influence of modelling approach on the association between the CFS score and short-term mortality and quantify the prognostic value of frailty in this context. Methods We analysed data from two multicentre prospective cohort studies which enrolled intensive care unit patients ≥ 80 years old in 26 countries. The primary outcome was mortality within 30-days from admission to the ICU. Logistic regression models for both ICU and 30-day mortality included the CFS score as either a categorical, continuous or dichotomous variable and were adjusted for patient’s age, sex, reason for admission to the ICU, and admission Sequential Organ Failure Assessment score. Results The median age in the sample of 7487 consecutive patients was 84 years (IQR 81–87). The highest fraction of new prognostic information from frailty in the context of 30-day mortality was observed when the CFS score was treated as either a categorical variable using all original levels of frailty or a nonlinear continuous variable and was equal to 9% using these modelling approaches (p < 0.001). The relationship between the CFS score and mortality was nonlinear (p < 0.01). Conclusion Knowledge about a patient’s frailty status adds a substantial amount of new prognostic information at the moment of admission to the ICU. Arbitrary simplification of the CFS score into fewer groups than originally intended leads to a loss of information and should be avoided. Trial registration NCT03134807 (VIP1), NCT03370692 (VIP2)

  • Survey on worldwide trauma team activation requirement
    Christian Waydhas, Heiko Trentzsch, Timothy C. Hardcastle, Kai Oliver Jensen, Khaled Tolba Younes Abdelmotaleb, George Abi Saad, Markus Baacke, Nehat Baftiu, Christos Bartsokas, Lars Becker,et al.
    Springer Science and Business Media LLC
    Abstract Purpose Trauma team activation (TTA) is thought to be essential for advanced and specialized care of very severely injured patients. However, non-specific TTA criteria may result in overtriage that consumes valuable resources or endanger patients in need of TTA secondary to undertriage. Consequently, criterion standard definitions to calculate the accuracy of the various TTA protocols are required for research and quality assurance purposes. Recently, several groups suggested a list of conditions when a trauma team is considered to be essential in the initial care in the emergency room. The objective of the survey was to post hoc identify trauma-related conditions that are thought to require a specialized trauma team that may be widely accepted, independent from the country’s income level. Methods A set of questions was developed, centered around the level of agreement with the proposed post hoc criteria to define adequate trauma team activation. The participants gave feedback before they answered the survey to improve the quality of the questions. The finalized survey was conducted using an online tool and a word form. The income per capita of a country was rated according to the World Bank Country and Lending groups. Results The return rate was 76% with a total of 37 countries participating. The agreement with the proposed criteria to define post hoc correct requirements for trauma team activation was more than 75% for 12 of the 20 criteria. The rate of disagreement was low and varied between zero and 13%. The level of agreement was independent from the country’s level of income. Conclusions The agreement on criteria to post hoc define correct requirements for trauma team activation appears high and it may be concluded that the proposed criteria could be useful for most countries, independent from their level of income. Nevertheless, more discussions on an international level appear to be warranted to achieve a full consensus to define a universal set of criteria that will allow for quality assessment of over- and undertriage of trauma team activation as well as for the validation of field triage criteria for the most severely injured patients worldwide.

  • SARS-CoV-2 vaccination modelling for safe surgery to save lives: data from an international prospective cohort study
    GlobalSurg Collaborative Covidsurg Collaborative, Ergin Erginöz, Juan J. Segura-Sampedro and Fardis Vosoughi
    Oxford University Press (OUP)
    Abstract Background Preoperative SARS-CoV-2 vaccination could support safer elective surgery. Vaccine numbers are limited so this study aimed to inform their prioritization by modelling. Methods The primary outcome was the number needed to vaccinate (NNV) to prevent one COVID-19-related death in 1 year. NNVs were based on postoperative SARS-CoV-2 rates and mortality in an international cohort study (surgical patients), and community SARS-CoV-2 incidence and case fatality data (general population). NNV estimates were stratified by age (18–49, 50–69, 70 or more years) and type of surgery. Best- and worst-case scenarios were used to describe uncertainty. Results NNVs were more favourable in surgical patients than the general population. The most favourable NNVs were in patients aged 70 years or more needing cancer surgery (351; best case 196, worst case 816) or non-cancer surgery (733; best case 407, worst case 1664). Both exceeded the NNV in the general population (1840; best case 1196, worst case 3066). NNVs for surgical patients remained favourable at a range of SARS-CoV-2 incidence rates in sensitivity analysis modelling. Globally, prioritizing preoperative vaccination of patients needing elective surgery ahead of the general population could prevent an additional 58 687 (best case 115 007, worst case 20 177) COVID-19-related deaths in 1 year. Conclusion As global roll out of SARS-CoV-2 vaccination proceeds, patients needing elective surgery should be prioritized ahead of the general population.

  • Frailty is associated with long-term outcome in patients with sepsis who are over 80 years old: Results from an observational study in 241 European ICUs
    Lenneke E M Haas, Ariane Boumendil, Hans Flaatten, Bertrand Guidet, Mercedes Ibarz, Christian Jung, Rui Moreno, Alessandro Morandi, Finn H Andersen, Tilemachos Zafeiridis,et al.
    Oxford University Press (OUP)
    Abstract Background Sepsis is one of the most frequent reasons for acute intensive care unit (ICU) admission of very old patients and mortality rates are high. However, the impact of pre-existing physical and cognitive function on long-term outcome of ICU patients ≥ 80 years old (very old intensive care patients (VIPs)) with sepsis is unclear. Objective To investigate both the short- and long-term mortality of VIPs admitted with sepsis and assess the relation of mortality with pre-existing physical and cognitive function. Design Prospective cohort study. Setting 241 ICUs from 22 European countries in a six-month period between May 2018 and May 2019. Subjects Acutely admitted ICU patients aged ≥80 years with sequential organ failure assessment (SOFA) score ≥ 2. Methods Sepsis was defined according to the sepsis 3.0 criteria. Patients with sepsis as an admission diagnosis were compared with other acutely admitted patients. In addition to patients’ characteristics, disease severity, information about comorbidity and polypharmacy and pre-existing physical and cognitive function were collected. Results Out of 3,596 acutely admitted VIPs with SOFA score ≥ 2, a group of 532 patients with sepsis were compared to other admissions. Predictors for 6-month mortality were age (per 5 years): Hazard ratio (HR, 1.16 (95% confidence interval (CI), 1.09–1.25, P < 0.0001), SOFA (per one-point): HR, 1.16 (95% CI, 1.14–1.17, P < 0.0001) and frailty (CFS > 4): HR, 1.34 (95% CI, 1.18–1.51, P < 0.0001). Conclusions There is substantial long-term mortality in VIPs admitted with sepsis. Frailty, age and disease severity were identified as predictors of long-term mortality in VIPs admitted with sepsis.

  • The contribution of frailty, cognition, activity of daily life and comorbidities on outcome in acutely admitted patients over 80 years in European ICUs: the VIP2 study
    Bertrand Guidet, , Dylan W. de Lange, Ariane Boumendil, Susannah Leaver, Ximena Watson, Carol Boulanger, Wojciech Szczeklik, Antonio Artigas, Alessandro Morandi,et al.
    Springer Science and Business Media LLC

  • ANTIBACTERIAL THERAPY FOR PURULENT-SEPTIC COMPLICATIONS IN PATIENTS WITH COMBAT RELATED PENETRATING CRANIOCEREBRAL GUNSHOT WOUNDS


  • Successful Surgical Treatment of Severe Perforating Diametric Craniocerebral Gunshot Wound Sustained during Combat: A Case Report
    Andrii Sirko, Igor Kyrpa, Ihor Yovenko, Kateryna Miziakina, and Dmytro Romanukha
    Oxford University Press (OUP)
    AbstractMany researchers classify perforating diametric craniocerebral gunshot wounds as fatal because mortality exceeds 96% and the majority of patients with such injuries die before hospitalization. A 23-year-old Ukrainian male soldier was admitted to a regional hospital with a severe perforating craniocerebral wound in a comatose state (Glasgow Coma Scale score, 5). Following brain helical computed tomography, the patient underwent primary treatment of the cerebral wound with primary duraplasty and inflow/outflow drainage. After 18 days of treatment in the intensive care unit, he was transferred to a military hospital for further rehabilitation. This report details our unusual case of successful treatment of a perforating diametric craniocerebral gunshot wound.

RECENT SCHOLAR PUBLICATIONS

  • Management and outcomes in critically ill nonagenarian versus octogenarian patients
    RR Bruno, B Wernly, M Kelm, A Boumendil, A Morandi, FH Andersen, ...
    BMC geriatrics 21, 1-14 2021

  • Survey on worldwide trauma team activation requirement
    C Waydhas, H Trentzsch, TC Hardcastle, KO Jensen
    European Journal of Trauma and Emergency Surgery 47, 1569-1580 2021

  • Frailty is associated with long-term outcome in patients with sepsis who are over 80 years old: results from an observational study in 241 European ICUs
    LEM Haas, A Boumendil, H Flaatten, B Guidet, M Ibarz, C Jung, R Moreno, ...
    Age and ageing 50 (5), 1719-1727 2021

  • High-flow oxygen therapy for intensive care severe exacerbation of chronic obstructive pulmonary disease: A case report
    I Yovenko, D Gavrychenko
    ANESTHESIA AND ANALGESIA 133 (3 S_ SUPPL), 249-249 2021

  • The contribution of frailty, cognition, activity of daily life and comorbidities on outcome in acutely admitted patients over 80 years in European ICUs: the VIP2 study
    B Guidet, DW De Lange, A Boumendil, S Leaver, X Watson, C Boulanger, ...
    Intensive care medicine 46, 57-69 2020

  • Post-intensive care syndrome (PICS) и профессиональное выгорание в АИТ
    ИА Йовенко, ИВ Балака
     2020

  • Интенсивная терапия гиповолемического шока: стратегия Fluid stewardship
    ИА Йовенко, ИВ Балака
    ГАЛИЦЬКІ АНЕСТЕЗІОЛОГІЧНІ ЧИТАННЯ: АКТУАЛЬНІ ПИТАННЯ АНЕСТЕЗІОЛОГІЇ ТА 2020

  • Successful Surgical Treatment of Severe Perforating Diametric Craniocerebral Gunshot Wound Sustained during Combat: A Case Report
    A Sirko, I Kyrpa, I Yovenko, K Miziakina, D Romanukha
    Military Medicine 184 (9-10), e575-e580 2019

  • Antibacterial Therapy for Purulent-Septic Complications in Patientswith Combat Related Penetrating Craniocerebral Gunshot Wounds
    A Sirko, I Yovenko, V Zhyliuk, M Mosentsev, G Pilipenko
    Georgian Medical News= Медицинские новости Грузии 9 (294), 10-16 2019

  • Prognostic factors of intracranial purulent-septic complications of combat-related gunshot penetrating skull and brain wounds
    AG Sirko, LA Dzyak, GS Pylypenko, IO Yovenko, AA Skrypnik
    Медичні перспективи 24 (3), 58-66 2019

  • Экстракорпоральная гемокоррекция по внепочечным показаниям в ОИТ
    ИА Йовенко, МЭ Павловский, ДГ Гавриченко, ВН Дубина
    Медицина невідкладних станів, 194-194 2019

  • Показания к жидкостной реанимации: мнение специалистов (Европа, США, Украина)
    ИА Йовенко, ИВ Балака
    Медицина невідкладних станів, 193-194 2019

  • Обзор мировой практики диагностики смерти мозга
    HV Kurochka, IO Yovenko, OV Tsariov
    EMERGENCY MEDICINE, 46-51 2018

  • Интенсивная терапия синдрома полиорганной недостаточности при политравме: место экстракорпоральной гемокоррекции
    IO Yovenko, OO Marzan, OV Tsariov, VM Dubyna, LV Kovalenko
    EMERGENCY MEDICINE, 191-195 2018

  • Clinical physiology and clinical pharmacology of modern infusion therapy of circulatory shock (literature review)
    IA Yovenko, AV Tsarev, A Kuz’mova Ye
    Emergency Medicine 5, 52-65 2018

  • Features of cognitive impairment in wounds received in combat conditions
    AA Krishtafor, IA Yovenko, VG Chernenko, KA Klimenko, DA Krishtafor
    Emergencymedicine 2 (81), 2224-0586.2 2018

  • Simultaneous Monitoring of Intracranial Pressure and Cerebral Blood Flow in Patients with Severe Brain Injury
    A Sirko, D Romanukha, V Grishin, I Yovenko, A Skripnik
    Archives in Neurology & Neuroscience 1 (3), 1-4 2018

  • Когнитивный профиль пострадавших при критических состояниях, связанных с боевой и небоевой травмой
    АА Криштафор, ИА Йовенко, ДА Криштафор, ДВ Оленюк
    Вісник проблем біології і медицини 2 (1 (143)), 141-145 2018

  • Транексамовая кислота–современный золотой стандарт интенсивной терапии периоперационной и травматической кровопотери
    ИА Йовенко, ИВ Балака
    Гострі та невідкладністани у практицілікаря, 14-17 2018

  • Клиническая физиология и клиническая фармакология современной инфузионной терапии циркуляторного шока (обзор литературы)
    ИА Йовенко, АВ Царев, ЕА Кузьмова, ВЮ Мынка, УВ Селезнева
    Медицина неотложных состояний, 52-65 2018

MOST CITED SCHOLAR PUBLICATIONS

  • The contribution of frailty, cognition, activity of daily life and comorbidities on outcome in acutely admitted patients over 80 years in European ICUs: the VIP2 study
    B Guidet, DW De Lange, A Boumendil, S Leaver, X Watson, C Boulanger, ...
    Intensive care medicine 46, 57-69 2020
    Citations: 375

  • Frailty is associated with long-term outcome in patients with sepsis who are over 80 years old: results from an observational study in 241 European ICUs
    LEM Haas, A Boumendil, H Flaatten, B Guidet, M Ibarz, C Jung, R Moreno, ...
    Age and ageing 50 (5), 1719-1727 2021
    Citations: 35

  • Интенсивная терапия политравмы с позиций современных международных рекомендаций
    ЮЮ Кобеляцкий, ИА Йовенко, АВ Царев, ЕА Кузьмова, МН Передерий
    Медицина неотложных состояний, 9-14 2013
    Citations: 21

  • Management and outcomes in critically ill nonagenarian versus octogenarian patients
    RR Bruno, B Wernly, M Kelm, A Boumendil, A Morandi, FH Andersen, ...
    BMC geriatrics 21, 1-14 2021
    Citations: 20

  • Survey on worldwide trauma team activation requirement
    C Waydhas, H Trentzsch, TC Hardcastle, KO Jensen
    European Journal of Trauma and Emergency Surgery 47, 1569-1580 2021
    Citations: 16

  • Гемодинамический мониторинг в практике интенсивной терапии критических состояний
    ИА Йовенко, ЮЮ Кобеляцкий, АВ Царев, ЕА Кузьмова, АМ Машин
    Медицина неотложных состояний, 42-46 2016
    Citations: 12

  • Интенсивная терапия кровопотери, коагулопатии и гиповолемического шока при политравме
    ИА Йовенко, ЮЮ Кобеляцкий, АВ Царев, ЕА Кузьмова, КА Клименко, ...
    Медицина неотложных состояний, 64-71 2016
    Citations: 12

  • Особенности когнитивных нарушений при ранениях, полученных в условиях боевых действий
    АА Криштафор, ИА Йовенко, ВГ Черненко, КА Клименко, ...
    Медицина неотложных состояний, 110-116 2017
    Citations: 10

  • Практика инфузионно-трансфузионной терапии кровотечений при тяжелой огнестрельной травме: вопросы выбора препаратов и целевых конечных точек
    ИА Йовенко, ЮЮ Кобеляцкий, АВ Царев, ВВ Петров, ЕА Кузьмова, ...
    Медицина неотложных состояний, 164-170 2015
    Citations: 10

  • Клиническая физиология и клиническая фармакология современной инфузионной терапии циркуляторного шока (обзор литературы)
    ИА Йовенко, АВ Царев, ЕА Кузьмова, ВЮ Мынка, УВ Селезнева
    Медицина неотложных состояний, 52-65 2018
    Citations: 7

  • Интенсивная терапия повреждений мозга и ранняя нейрореабилитация при политравме с превалированием тяжелой черепно-мозговой травмы. Опыт применения оригинального АМАНТАДИНА
    ЛА Дзяк, ЮЮ Кобеляцкий, ИА Йовенко, АВ Царев
    Медицина неотложных состояний, 57-65 2015
    Citations: 7

  • Intensive care of multiple trauma from modern international guidelines positions
    K YuYu, IA Yovenko, AV Tsarev
    Medycyna nevidkladnyh staniv 7 (54), 9-14 2013
    Citations: 7

  • Вегетативный компонент регионарной анестезии периферических нервов, его оценка и клиническое значение
    ИА Йовенко
    Укр. журн. екстрем. мед, 37-41 2008
    Citations: 7

  • Clinical physiology and clinical pharmacology of modern infusion therapy of circulatory shock (literature review)
    IA Yovenko, AV Tsarev, A Kuz’mova Ye
    Emergency Medicine 5, 52-65 2018
    Citations: 6

  • Hemodynamic monitoring in the practice of intensive care of critical conditions
    I Yovenko, K Yu, A Tsarev
    Medicine of emergency 5 (76), 42-46 2016
    Citations: 6

  • Бактериальный контроль при тяжелой огнестрельной травме
    ИА Йовенко, ДА Криштафор, ЮЮ Кобеляцкий, ВЮ Мынка, АВ Царев, ...
    Медицина неотложных состояний, 171-175 2015
    Citations: 6

  • Features of cognitive impairment in wounds received in combat conditions
    AA Krishtafor, IA Yovenko, VG Chernenko, KA Klimenko, DA Krishtafor
    Emergencymedicine 2 (81), 2224-0586.2 2018
    Citations: 5

  • Качественная клиническая практика стартовой интенсивной терапии при боевой и цивильной политравме (обзор литературы)
    ИА Йовенко, ЮЮ Кобеляцкий, АВ Царев, ЕА Кузьмова, ЛЛ Дубовская, ...
    Медицина неотложных состояний, 39-50 2017
    Citations: 5

  • Рабдомиолиз при минно-взрывной травме: современные принципыи собственный опыт интенсивной терапии
    ЮЮ Кобеляцкий, АВ Царев, ИА Йовенко, ВН Дубина, ДП Яковенко, ...
    Медицина неотложных состояний, 128-134 2017
    Citations: 5

  • Tsarev AV Intensivnaya terapiya povrezhdeniy mozga i rannyaya neyroreabilitatsiya pri politravme s prevalirovaniem tyazheloy cherepno-mozgovoy travmy. Opyt primeneniya original
    LA Dzyak, KY Yu, IA Yovenko
    Meditsina neotlozhnykh sostoyaniy 8 (71), 57-65 2015
    Citations: 5