Prof. Dr. med. Harald H.H.W. Schmidt

@maastrichtuniversity.nl

Professor and Head of Department of Pharmacology and Personalised Medicine
Universiteit Maastricht

RESEARCH, TEACHING, or OTHER INTERESTS

Multidisciplinary, Medicine, Pharmacology, Toxicology and Pharmaceutics, Biochemistry, Genetics and Molecular Biology

39643

Scholar Citations

103

Scholar h-index

233

Scholar i10-index

RECENT SCHOLAR PUBLICATIONS

  • From Genomic Puzzles to Network Solutions: Charting Parkinson’s Path using Systematic Review/Meta Analysis as the Compass
    Z Piper, ZM Maamdouh, MP Pachado, RA Reijnders, E Pishva, ...
    RExPO22 Conference 2023

  • Drug Repurposing: The End of Medicines As We Knew Them
    HHHW Schmidt
    RExPO22 Conference 2023

  • The concise guide to PHARMACOLOGY 2023/24: catalytic receptors
    SPH Alexander, D Fabbro, E Kelly, AA Mathie, JA Peters, EL Veale, ...
    British Journal of Pharmacology 180, S241-S288 2023

  • Receptor guanylyl cyclase (RGC) family in GtoPdb v. 2023.1
    A Beuve, P Brouckaert, JC Burnett Jr, A Friebe, J Garthwaite, AJ Hobbs, ...
    IUPHAR/BPS Guide to Pharmacology CITE 2023 (1) 2023

  • Understanding (apo-) soluble guanylate cyclase allosterism and its therapeutic implications
    A Petraina, MH Elbatreek, CT Neullens, T Saridaki, VTV Dao, AI Casas, ...
    DrugRxiv 2023

  • Why the way we define diseases prevents innovation and precision medicine
    ZMMA Gomaa, E Anastasi, A Hassan, J Boltze, M Elbatreek, CN Calvo, ...
    2023

  • From phenotype to endotype: preclinical validation of ROS-cGMPopathies in the Estonian Biobank
    C Nogales, J Kronberg, A Petraina, MP Pachado, J Weerts, AB Aizpurua, ...
    JOURNAL OF TRANSLATIONAL MEDICINE 21 (SUPPL 1) 2023

  • On a revised pharmacology of apo-soluble guanylate cyclase and its therapeutic implications
    A Petraina, MH Elbatreek, CT Neullens, T Saridaki, VTV Dao, AI Casas, ...
    DrugRxiv 2023

  • Re-Addressing Dementia by Network Medicine and Mechanism-Based Molecular Endotypes
    M Pacheco Pachado, AI Casas, MH Elbatreek, C Nogales, E Guney, ...
    Journal of Alzheimer's Disease, 1-10 2023

  • The FeatureCloud platform for federated learning in biomedicine: unified approach
    J Matschinske, J Spth, M Bakhtiari, N Probul, MMK Majdabadi, ...
    Journal of Medical Internet Research 25 (1), e42621 2023

  • Soluble guanylate cyclase stimulator riociguat improves spatial memory in mice via peripheral mechanisms
    E Nelissen, BTJ van Hagen, EK Argyrousi, NP van Goethem, ...
    Neuroscience Letters 788, 136840 2022

  • REPO4EU: The end of drug discovery as we know it
    HHHW Schmidt
    RExPO22 2022

  • Repurposing soluble guanylate cyclase stimulators from one to another isoform within the ROCG signalling module
    A Petraina, MH Elbatreek, C Elgert, AI Casas, CT Neullens, T Saridaki, ...
    RExPO22 2022

  • An organ-agnostic drug repurposing strategy for dementia: Pre-clinical validation of network pharmacology to treat cerebrovascular dysfunction and cognitive impairment
    M Pacheco Pachado, A Petraina, C Nogales, T Saridaki, HHHW Schmidt, ...
    RExPO22 2022

  • Network pharmacology and drug repurposing pave the way for precision oncology
    ZM Mamdouh, C Nogales, C Macchiusi, MH Elbatreek, ...
    RExPO22 2022

  • NeDRex-an integrative and interactive network medicine platform for drug repurposing
    S Sadegh, J Skelton, E Anastasi, DB Blumenthal, A Maier, G Galindez, ...
    RExPO22 2022

  • Network modules as molecular disease definitions for mechanism-based endotyping anddrug repurposing
    C Nogales Calvo, AI Casas, A Petraina, M Pacheco Pachado, S Sadegh, ...
    RExPO22 2022

  • Network pharmacology drug repurposing strategy for neurovascular diseases
    AI Casas, C Nogales, MH Elbatreek, S Sadegh, E Anastasi, J Skelton, ...
    RExPO22 2022

  • Un-biased housekeeping gene panel selection for high-validity gene expression analysis
    AI Casas, AA Hassan, Q Manz, C Wiwie, P Kleikers, J Egea, MG Lpez, ...
    Scientific Reports 12 (1), 12324 2022

  • Endothelial reactive oxygen-forming NADPH oxidase 5 is a possible player in diabetic aortic aneurysm but not atherosclerosis
    F Ho, AMD Watson, MH Elbatreek, PWM Kleikers, W Khan, KC Sourris, ...
    Scientific Reports 12 (1), 11570 2022

MOST CITED SCHOLAR PUBLICATIONS

  • NO at work
    HHHW Schmidt, U Walter
    Cell 78 (6), 919-925 1994
    Citations: 2029

  • Purification and characterization of particulate endothelium-derived relaxing factor synthase from cultured and native bovine aortic endothelial cells.
    JS Pollock, U Frstermann, JA Mitchell, TD Warner, HH Schmidt, ...
    Proceedings of the National Academy of Sciences 88 (23), 10480-10484 1991
    Citations: 1256

  • Isoforms of nitric oxide synthase characterization and purification from different cell types
    U Frstermann, HHHW Schmidt, JS Pollock, H Sheng, JA Mitchell, ...
    Biochemical pharmacology 42 (10), 1849-1857 1991
    Citations: 1161

  • The nitric oxide and cGMP signal transduction system: regulation and mechanism of action
    HHHW Schmidt, SM Lohmann, U Walter
    Biochimica et Biophysica Acta (BBA)-Molecular Cell Research 1178 (2), 153-175 1993
    Citations: 1033

  • NO-independent stimulators and activators of soluble guanylate cyclase: discovery and therapeutic potential
    OV Evgenov, P Pacher, PM Schmidt, G Hask, HHHW Schmidt, JP Stasch
    Nature reviews Drug discovery 5 (9), 755-768 2006
    Citations: 905

  • Clinical relevance of biomarkers of oxidative stress
    J Frijhoff, PG Winyard, N Zarkovic, SS Davies, R Stocker, D Cheng, ...
    Antioxidants & redox signaling 23 (14), 1144-1170 2015
    Citations: 854

  • Apocynin is not an inhibitor of vascular NADPH oxidases but an antioxidant
    S Heumüller, S Wind, E Barbosa-Sicard, HHHW Schmidt, R Busse, ...
    Hypertension 51 (2), 211-217 2008
    Citations: 851

  • Calmodulin-dependent endothelium-derived relaxing factor/nitric oxide synthase activity is present in the particulate and cytosolic fractions of bovine aortic endothelial cells.
    U Frstermann, JS Pollock, HH Schmidt, M Heller, F Murad
    Proceedings of the National Academy of Sciences 88 (5), 1788-1792 1991
    Citations: 785

  • Cloned human brain nitric oxide synthase is highly expressed in skeletal muscle
    M Nakane, HHHW Schmidt, JS Pollock, U Frstermann, F Murad
    FEBS letters 316 (2), 175-180 1993
    Citations: 738

  • Mapping of neural nitric oxide synthase in the rat suggests frequent co-localization with NADPH diaphorase but not with soluble guanylyl cyclase, and novel paraneural functions
    HH Schmidt, GD Gagne, M Nakane, JS Pollock, MF Miller, F Murad
    Journal of Histochemistry & Cytochemistry 40 (10), 1439-1456 1992
    Citations: 715

  • Direct interaction of the novel Nox proteins with p22phox is required for the formation of a functionally active NADPH oxidase
    RK Ambasta, P Kumar, KK Griendling, HHHW Schmidt, R Busse, ...
    Journal of Biological Chemistry 279 (44), 45935-45941 2004
    Citations: 665

  • Nitric oxide synthase in macula densa regulates glomerular capillary pressure.
    CS Wilcox, WJ Welch, F Murad, SS Gross, G Taylor, R Levi, HH Schmidt
    Proceedings of the National Academy of Sciences 89 (24), 11993-11997 1992
    Citations: 627

  • Evolution of NADPH oxidase inhibitors: selectivity and mechanisms for target engagement
    S Altenhfer, KA Radermacher, PWM Kleikers, K Wingler, HHHW Schmidt
    Antioxidants & redox signaling 23 (5), 406-427 2015
    Citations: 559

  • Arginine is a physiological precursor of endothelium-derived nitric oxide
    HHHW Schmidt, H Nau, W Wittfoht, J Gerlach, KE Prescher, MM Klein, ...
    European journal of pharmacology 154 (2), 213-216 1988
    Citations: 551

  • Purification of a soluble isoform of guanylyl cyclase-activating-factor synthase
    H Schmidt, JS Pollock, M Nakane, LD Gorsky, U Frstermann, F Murad
    Proc. Natl. Acad. Sci. USA 88 (2), 365-369 1991
    Citations: 543

  • Insulin secretion from pancreatic B cells caused by L-arginine-derived nitrogen oxides
    HHHW Schmidt, TD Warner, K Ishii, H Sheng, FF Murad
    Science 255 (5045), 721-723 1992
    Citations: 537

  • Transcription factor NRF2 as a therapeutic target for chronic diseases: a systems medicine approach
    A Cuadrado, G Manda, A Hassan, MJ Alcaraz, C Barbas, A Daiber, ...
    Pharmacological reviews 70 (2), 348-383 2018
    Citations: 534

  • Targeting the heme-oxidized nitric oxide receptor for selective vasodilatation of diseased blood vessels
    JP Stasch, PM Schmidt, PI Nedvetsky, TY Nedvetskaya, AK HS, S Meurer, ...
    The Journal of clinical investigation 116 (9), 2552-2561 2006
    Citations: 521

  • Nox1 Overexpression Potentiates Angiotensin II-Induced Hypertension and Vascular Smooth Muscle Hypertrophy in Transgenic Mice
    A Dikalova, R Clempus, B Lassgue, G Cheng, J McCoy, S Dikalov, ...
    Circulation 112 (17), 2668-2676 2005
    Citations: 497

  • The concise guide to pharmacology 2019/20: Enzymes
    SPH Alexander, D Fabbro, E Kelly, A Mathie, JA Peters, EL Veale, ...
    British Journal of Pharmacology 176, S297-S396 2019
    Citations: 496