Mikhail Panfilov
@nioch.nsc.ru
N.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry of Siberian Branch of Russian Academy of Sciences
Scopus Publications
Scopus Publications
Natalia A. Virts, Tatyana Yu. Karogodina, Mikhail A. Panfilov, Alexey Yu. Vorob’ev, and Alexander E. Moskalensky
MDPI AG
Nitric oxide (NO) is a unique biochemical mediator involved in the regulation of vital processes. Light-controllable NO releasers show promise in the development of smart therapies. Here, we present a novel biocompatible material based on polydimethylsiloxane (PDMS) doped with BODIPY derivatives containing an N-nitroso moiety that is capable of the photoinduced generation of NO. We study the green-light-induced NO-release properties with the following three methods: electrochemical gas-phase sensor, liquid-phase sensor, and the Griess assay. Prolonged release of NO from the polymer films after short irradiation by narrow-band LED light sources and a laser beam is demonstrated. Importantly, this was accompanied by no or little release of the parent compound (BODIPY-based photodonor). Silicone films with the capability of controllable and clean NO release can potentially be used as a highly portable NO delivery system for different therapeutic applications.
Mikhail A. Panfilov, Tatyana Yu. Karogodina, Anastasiya A. Sibiryakova, Irina S. Tretyakova, Alexey Yu. Vorob'ev, and Alexander E. Moskalensky
Wiley
AbstractNitric oxide (NO) is a unique biochemical mediator involved in the regulation of vital processes. Its short lifetime in physiological conditions and local action impede direct application in medicine because highly targeted NO‐delivery systems are required. Light‐controllable NO releasers are promising for the development of smart therapies. Here we present simply prepared meso‐aminomethyl BODIPY (4,4‐difluoro‐4‐bora‐3a,4a‐diaza‐s‐indacene) derivatives containing N‐nitroso moiety, which show the photoinduced generation of NO in a solution. These compounds can additionally generate singlet oxygen, and NO/1O2 generation efficiency can be tuned by substituents. As an example of NO‐mediated effect, we demonstrate light‐dependent inhibition of platelet activation in vitro. The presented compounds could serve as the basis for the development of novel hybrid therapeutic methods.
E.O. Zhermolenko, T.Yu. Karogodina, A.Yu. Vorobev, M.A. Panfilov, and A.E. Moskalensky
Elsevier BV
Mikhail A. Panfilov, Tatyana Yu. Karogodina, Yao Songyin, Oleg Yu. Karmatskih, Alexey Yu. Vorob'ev, Irina S. Tretyakova, Evgeni M. Glebov, and Alexander E. Moskalensky
Elsevier BV
Mikhail Panfilov, Darya Chernova, Irina Khalfina, Alexander Moskalensky, and Aleksey Vorob’ev
MDPI AG
Nitric oxide (NO) is an important signaling molecule involved in a wide range of physiological and pathological processes. Fluorescent imaging is a useful tool for monitoring NO concentration, which could be essential in various biological and biochemical studies. Here, we report the design of a novel small-molecule fluorescent probe based on 9(10H)acridone moiety for nitric oxide sensing. 7,8-Diamino-4-carboxy-10-methyl-9(10H)acridone reacts with NO in aqueous media in the presence of O2, yielding a corresponding triazole derivative with fivefold increased fluorescence intensity. The probe was shown to be capable of nitric oxide sensing in living Jurkat cells.
Viktoriya А. Sannikova, Igor R. Filippov, Oleg Yu. Karmatskikh, Mikhail А. Panfilov, Rodion V. Andreev, and Aleksey Yu. Vorob’ev
Springer Science and Business Media LLC