Baburao N Chandakavathe

@pharmacycol.com

Assistant professor
DSTS mandals college of pharmacy, solapur

Profile Summary
Mr. Baburao N. Chandakavathe Assistant Professor at D.S.T.S. Mandal’s College of Pharmacy, Jule Solapur, Solapur. He completed his graduation and post graduation degree from Rajiv Gandhi University of Health Sciences, Karnataka, Bangalore. Mr. Baburao, qualified GATE and received several scholarships and awards during his studies. His research interests are Polymeric science, Extraction and formulation of herbal preparations, Novel Drug Delivery Systems. He is serving as Editorial Board Member and Reviewer for many reputed national and international journals. Mr. Baburao, has more than 10 years of teaching and research experience. Mr. Baburao, has presented scientific posters in national and international workshops/conferences. There are 12 publications in national and international journals with good impact factor.
Teaching Experience
UG Teaching Experience: 10 Years (Subject Taught: Pharmaceutics-I, Industrial Pharmacy-I)
PG subject taught: Advanced Pharmaceutics,

EDUCATION

M. Pharm. in Pharmaceutics
Pursuing PhD

RESEARCH INTERESTS

Herbs
Natural polymers
Grafting of natural polymers
Drug delivery system
Dosage forms

Scopus Publications

237

Scholar Citations

Scholar h-index

Scholar i10-index

Scopus Publications

Synthesis and Assessment of Acrylamide-graft-mesquite gum polymer (Aam-g-MG) for its Biodegradability in E. coli and Toxicity in Drosophila melanogaster
Baburao N. Chandakavathe and Ravindra Kulkarni
A and V Publications
Aim of the present investigation was to develop a novel, non-toxic and biodegradable copolymer of acrylamide-graft-mesquite gum polymer (Aam-g-MGP) by graft copolymerisation technique using cerric ammonium nitrate as free radical initiator under microwave conditions. The mesquite raw gum was purified and and grafted with acrylamide using ceric ammonium nitrate as a free radical initiator. The variation in reaction parameters affected the percent grafting (%G) and grafting efficiency (%GE) of the copolymer samples. The grafting was confirmed by FT-IR and elemental analysis, FT-IR spectral studies and elemental analysis data supported the grafting process. Subsequently synthesised graft copolymer was subjected for viscosity, water retention, swelling index and hydration capacity evaluation. Modified polymer was also tested for biodegradability on E. coli, and toxicity in Drosophila melanogaster. The developed copolymer demonstrated considerably increase in viscosity, water retention capacity, swelling index, and hydration capacity as compared to ungrafted mesquite gum polymer. The grafted copolymer Aam-g-MGP was proved biodegradable and non-toxic in nature. Based on the results swelling index and water retention capacity developed copolymer can be used in the development of extended release pharmaceutical formulations.

Development of Colon Targeted Extended Drug Delivery System for Mebendazole Using Grafted Natural Polymers
Baburao Nanasaheb Chandakavathe, Ravindra Kulkarni, Akash Dadanna Rajmane, Snehal Limbraj Mane, and Nishigandha Jayant Waykule
EManuscript Technologies
Background: Even though the natural polymers are biodegradable, non-toxic and cost effective, but these suffer with some of drawbacks like uncontrolled drug release, enzymatic degradation, reduction in viscosity on long term storage, thermal instability etc. The aforesaid limitations can be overcome by grafting of natural polymers to obtain high performance biomaterials for drug delivery system. Materials and Methods: Purified fenugreek and mesquite gums were grafted with acrylamide using Ceric Ammonium Nitrate (CAN) as free radical initiator. Confirmation of grafting was done by elemental analysis and FT-IR spectroscopy. Grafted copolymers were tested for its biodegradability in microorganisms and toxicity in Drosophila melanogaster . Nine batches of mebendazole tablets (F1 to F9) were prepared using mixture of acrylamide grafted fenugreek and mesquite gum polymer by 3 2 factorial designs. Compressed tablets were tested for post-compression compendia parameters. Results: FT-IR confirmed the grafting and compatibility between drug and synthesized copolymers. Synthesised graft copolymers showed significant swelling index, water retention capacity, viscosity, hydration capacity than the pure gum polymers. Compressed tablets showed hardness (5.5 to 6.6 kg/cm 2 ), friability (less than 1%). thickness (3 mm) and complied weight variation test as per compendial standards. Further tablets were coated with Eudragit RS 100 demonstrated small amount of drug release in 5 hr and maximum amount of drug released in colonic region. Hence, after reaching colonic region drug release extended upto 12 hr due to satisfactory drug release by copolymers. Conclusion: Grafted copolymers were biodegradable, non-toxic and showed higher swelling index then pure polymers. These copolymers can be used as drug release retardant in the tablet formulation.

Formulation and Assessment of In Vitro Antimicrobial Activity of Herbal Toothpaste
Baburao N. Chandakavathe, Ravindra G. Kulkarni, and Shivsharan B. Dhadde
Springer Science and Business Media LLC

Grafting of Natural Polymers and Gums for Drug Delivery Applications: A Perspective Review
Baburao N. Chandakavathe, Ravindra G. Kulkarni, and Shivsharan B. Dhadde
Begell House
Natural polymers have received more attention because of their advantages over synthetic polymers such as abundant availability, low cost, biodegradability and non-toxicity. However, natural polymers suffer some limitations such as drop-in viscosity upon storage, uncontrolled hydration, solubility, inability to perform under high temperature and pressure (thermal stability), etc. In many instances above mentioned drawbacks of natural polymers limits their applications in drug delivery systems. Grafting of natural polymer leads to improved properties and characteristics of backbones of macromolecules such as improvement in gel strength, swelling index, mucoadhesion, drug targeting and drug release profile. Therefore, in recent decades grafting of the natural polymer has gained immense importance for the development of drug delivery systems. In addition to the pharmaceutical applications graft copolymers are extensively utilized in diversified fields. The present review is an attempt to define the grafting, various methods of polymer grafting and their application in drug delivery.

Relevance of nanotechnology in solving oral drug delivery challenges: A perspective review
Shivsharan B. Dhadde, Jagadevappa S. Patil, Baburao N. Chandakavathe, B. S. Thippeswamy, and Mahantesh G. Kavatekar
Begell House
Nanotechnology is opening up new opportunities in drug delivery, including oral delivery, and it may reduce toxicity and increase drug ability. Presently, researchers are expanding their knowledge in the development of oral nanomedicine to extend the scope of oral drug delivery and exhibit excellent platforms for drug transportation, target, and controlled release. The present review is an attempt to define updated oral nanostructured systems for the delivery of a wide range of drugs. The review also focuses on the use of different polymeric and other materials, technologies adopted, and benefits/drawbacks of delivery systems.

Assessment of Toothpaste Formulations Containing Turmeric and Neem Extract for Prevention of Dental Caries and Periodontal Diseases
Baburao N. Chandakavathe, Deepak K. Deshpande, P. V. Swamy, and Shivsharan B. Dhadde
Springer Science and Business Media LLC

Nanostructure Drug Delivery System Is an Option to Solve Antimicrobial Drug Resistance: Perspective Review. Perspective Review.
Jagadevappa S. Patil, Shivsharan B. Dhadde, and Baburao N. Chandakavathe
Elsevier

Embelin Ameliorate Testosterone-Induced Prostatic Hyperplasia in Rats
Marulasiddeshwara Roopesh, S. R. Anand Kumar, Shivsharan B. Dhadde, B. S. Thippeswamy, Veeresh P. Veerapur, S. Badami, and N. C. K. Baburao
Springer Science and Business Media LLC

Ameliorative effect of chromium-D-phenylalanine complex on indomethacin-induced inflammatory bowel disease in rats
S. Nagarjun, Shivsharan B. Dhadde, Veeresh P. Veerapur, B.S. Thippeswamy, and Baburao N. Chandakavathe
Elsevier BV

Immunomodulatory effect of decalepis hamiltonii wight and arn roots extract on rodents

RECENT SCHOLAR PUBLICATIONS

Synthesis and Assessment of Acrylamide-graft-mesquite gum polymer (Aam-g-MG) for its Biodegradability in E. coli and Toxicity in Drosophila melanogaster
BN Chandakavathe, R Kulkarni
Research Journal of Pharmacy and Technology 17 (11), 5555-5560 2024

Development of Colon Targeted Extended Drug Delivery System for Mebendazole Using Grafted Natural Polymers
BN Chandakavathe, R Kulkarni, AD Rajmane, SL Mane, NJ Waykule
Indian Journal of Pharmaceutical Education and Research 58 (3s), s837-s847 2024

Formulation and assessment of in vitro antimicrobial activity of herbal toothpaste
BN Chandakavathe, RG Kulkarni, SB Dhadde
Proceedings of the National Academy of Sciences, India Section B: Biological 2023

Grafting of natural polymers and gums for drug delivery applications: A perspective review
BN Chandakavathe, RG Kulkarni, SB Dhadde
Critical Reviews™ in Therapeutic Drug Carrier Systems 39 (6) 2022

Relevance of nanotechnology in solving oral drug delivery challenges: A perspective review
SB Dhadde, JS Patil, BN Chandakavathe, BS Thippeswamy, ...
Critical Reviews™ in Therapeutic Drug Carrier Systems 37 (5) 2020

Textbook of Industrial Pharmacy
BNCSB Dhadde
Studium press New Delhi 1, 523 2019

Nanostructure drug delivery system is an option to solve antimicrobial drug resistance: perspective review
JS Patil, SB Dhadde, BN Chandakavathe
Characterization and Biology of Nanomaterials for Drug Delivery, 165-197 2019

Assessment of toothpaste formulations containing turmeric and neem extract for prevention of dental caries and periodontal diseases
BN Chandakavathe, DK Deshpande, PV Swamy, SB Dhadde
Proceedings of the National Academy of Sciences, India Section B: Biological 2018

Characterization and biology of nanomaterials for drug delivery: nanoscience and nanotechnology in drug delivery
S Mohapatra, S Ranjan, N Dasgupta, S Thomas, RK Mishra
Elsevier 2018

Embelin Ameliorate Testosterone-Induced Prostatic Hyperplasia in Rats
M Roopesh, SR Anand Kumar, SB Dhadde, BS Thippeswamy, ...
Proceedings of the National Academy of Sciences, India Section B: Biological 2018

Embelin ameliorate testosterone-induced prostatic hyperplasia in rats.
MR Marulasiddeshwara Roopesh, SRA Kumar, SB Dhadde, ...
2018

Anti-diabetic Potential of Flavonoids and Their Molecular Mechanisms – A Review
BNC Shivsharan B. Dhadde
Recent Advances in the Molecular Mechanism of Flavonoids 1 (1), 104-139 2017

Ameliorative effect of chromium-d-phenylalanine complex on indomethacin-induced inflammatory bowel disease in rats
S Nagarjun, SB Dhadde, VP Veerapur, BS Thippeswamy, ...
Biomedicine & Pharmacotherapy 89, 1061-1066 2017

Indian Journal of Novel Drug Delivery
SM GHURGHURE, BN CHANDAKAVATHE
Indian Journal of Novel Drug delivery 8 (2), 93-99 2016

Effect of embelin against 3-nitropropionic acid-induced Huntington's disease in rats
SB Dhadde, P Nagakannan, M Roopesh, SRA Kumar, BS Thippeswamy, ...
Biomedicine & Pharmacotherapy 77, 52-58 2016

Design and Development of Spherical Agglomerates of Drug for the Enhancement of Solubility
BNSM GHURGHURE
Indian Journal of Novel Drug Delivery 8 (2), 93-99 2016

Formulation and Evaluation of Famotidine Gastro-Retentive Floating Matrix Tablets by Using Natural and Synthetic Polymers
PD Sumit Gaikwad, L N Jamagondi, Baburao N. Chandakavathe
International Journal of Pharmacy and Pharmaceutical Sciences 6 (4) 2016

FORMULATION AND EVALUATION OF MATRIX TABLETS FOR COLON SPECIFIC DELIVERY OF MEBENDAZOLE
MG Kavatekar, CC Patil, RV Kulkarni, AS Shahapur, SB Girani, ...
2015

DESIGN OF MUCOADHESIVE FLUCONAZOLE MOUTH PAINT FOR ORAL THRUSH IN HIV PATIENTS
KP Rao, S Zakaullah, A Ara, M Reddy, VR Patil, NCK Baburao, ...
International Journal of Pharmacology and Biological Sciences 5 (1), 53 2011

Formulation development of Mucoadhesive Fluconazole mouth paint for Oral Candidiasis
MP K.Purushotham Rao, Girish Katti , Mallikarjun Reddy , Supriya Aggarwal ...
Journal of Pharmaceutics and Cosmetology 1 (3), 35-43 2011

MOST CITED SCHOLAR PUBLICATIONS

Effect of embelin against 3-nitropropionic acid-induced Huntington's disease in rats
SB Dhadde, P Nagakannan, M Roopesh, SRA Kumar, BS Thippeswamy, ...
Biomedicine & Pharmacotherapy 77, 52-58 2016
Citations: 83

Characterization and biology of nanomaterials for drug delivery: nanoscience and nanotechnology in drug delivery
S Mohapatra, S Ranjan, N Dasgupta, S Thomas, RK Mishra
Elsevier 2018
Citations: 44

Formulation and evaluation of anti-asthmatic theophylline tablet lozenges
RK Purushotham, KC Ashok, AKB Afshanlaheji, P Manjunath, ...
Int J Pharm Sci 3 (1), 125-8 2011
Citations: 18

Grafting of natural polymers and gums for drug delivery applications: A perspective review
BN Chandakavathe, RG Kulkarni, SB Dhadde
Critical Reviews™ in Therapeutic Drug Carrier Systems 39 (6) 2022
Citations: 8

Design and Development of Spherical Agglomerates of Drug for the Enhancement of Solubility
BNSM GHURGHURE
Indian Journal of Novel Drug Delivery 8 (2), 93-99 2016
Citations: 6