Muhammad Naveed
@d.umn.edu
Postdoctoral Associate
University of Minnesota Duluth
Muhammad Naveed currently works at the University of Minnesota Duluth, United States. Naveed conducted research in "brain and neurosciences" and heart failure.
EDUCATION
PharmD, PhD.
RESEARCH INTERESTS
Brain and neurosciences
Scopus Publications
Scopus Publications
Muhammad Naveed, Muhammad Azam, Nasrullah Khan, Muhammad Aslam, Muhammad Saleem, and Muhammad Saeed
Springer Science and Business Media LLC
AbstractThis manuscript presents the development of an attribute control chart (ACC) designed to monitor the number of defective items in manufacturing processes. The charts are specifically tailored using time-truncated life test (TTLT) for two lifetime data distributions: the half-normal distribution (HND) and the half-exponential power distribution (HEPD) under a repetitive sampling scheme (RSS). To assess the effectiveness of the proposed control charts, both in-control (IC) and out-of-control (OOC) scenarios are considered by deriving the average run length (ARL). Various factors, including sample sizes, control coefficients, and truncated constants for shifted phases, are taken into account to evaluate the performance of the charts in terms of ARL. The behavior of ARLs is analyzed in the shifted process by introducing shifts in its parameters. The superiority of the HEPD-based chart is highlighted by comparing it with both the HND-based ACC and the ACC based on the Exponential distribution (ED) under TTLT using RSS. The results showcase the superior performance of the proposed HEPD-based chart, indicated by smaller ARL values. Additionally, the benefits of another proposed ACC using HND are compared with the ED-based ACC under RSS, further confirming the effectiveness of the HND-based approach through smaller ARLs Finally, the proposed control charts are evaluated through simulation testing and real-life implementation, emphasizing their practical applicability in real-world manufacturing settings.
Muhammad Naveed, Owen Y. Chao, Jennifer W. Hill, Yi-Mei Yang, Joseph P. Huston, and Ruifeng Cao
Elsevier BV
Muhammad Awais, Hafiz Muhammad Zubair, Humaira Nadeem, Jennifer W. Hill, Jawad Ali, Ammara Saleem, Rabia Asghar, Samiullah Khan, Tahir Maqbool, Muhammad Furqan Akhtar,et al.
Springer Science and Business Media LLC
Ammara Saleem, Maira Javed, Muhammad Furqan Akhtar, Ali Sharif, Bushra Akhtar, Muhammad Naveed, Uzma Saleem, Mirza Muhammad Faran Ashraf Baig, Hafiz Muhammad Zubair, Talha Bin Emran,et al.
Bentham Science Publishers Ltd.
Background: MicroRNAs (miRNA) are small noncoding RNAs that play a significant role in the regulation of gene expression. The literature has explored the key involvement of miRNAs in the diagnosis, prognosis, and treatment of various neurodegenerative diseases (NDD), such as Alzheimer’s disease (AD), Parkinson’s disease (PD), and Huntington’s disease (HD). The miRNA regulates various signalling pathways; its dysregulation is involved in the pathogenesis of NDD. Objective: The present review is focused on the involvement of miRNAs in the pathogenesis of NDD and their role in the treatment or management of NDD. The literature provides comprehensive and cutting-edge knowledge for students studying neurology, researchers, clinical psychologists, practitioners, pathologists, and drug development agencies to comprehend the role of miRNAs in the NDD’s pathogenesis, regulation of various genes/signalling pathways, such as α-synuclein, P53, amyloid-β, high mobility group protein (HMGB1), and IL-1β, NMDA receptor signalling, cholinergic signalling, etc. Methods: The issues associated with using anti-miRNA therapy are also summarized in this review. The data for this literature were extracted and summarized using various search engines, such as Google Scholar, Pubmed, Scopus, and NCBI using different terms, such as NDD, PD, AD, HD, nanoformulations of mRNA, and role of miRNA in diagnosis and treatment. Results: The miRNAs control various biological actions, such as neuronal differentiation, synaptic plasticity, cytoprotection, neuroinflammation, oxidative stress, apoptosis and chaperone-mediated autophagy, and neurite growth in the central nervous system and diagnosis. Various miRNAs are involved in the regulation of protein aggregation in PD and modulating β-secretase activity in AD. In HD, mutation in the huntingtin (Htt) protein interferes with Ago1 and Ago2, thus affecting the miRNA biogenesis. Currently, many anti-sense technologies are in the research phase for either inhibiting or promoting the activity of miRNA. Conclusion: This review provides new therapeutic approaches and novel biomarkers for the diagnosis and prognosis of NDDs by using miRNA.
Hao Lin, Muhammad Naveed, Aidan Hansen, Tracy G. Anthony, and Ruifeng Cao
MDPI AG
The circadian clock regulates a variety of biological processes that are normally synchronized with the solar day. Disruption of circadian rhythms is associated with health problems. Understanding the signaling mechanisms that couple cell physiology and metabolism to circadian timekeeping will help to develop novel therapeutic strategies. The integrated stress response (ISR) is activated by the cellular stressors to maintain physiological homeostasis by orchestrating mRNA translation. Aberrant ISR has been found in a number of neurological diseases that exhibit disrupted circadian rhythms and sleep. Recent work has started to uncover a critical role for the ISR in regulating the physiology of the circadian clock. Guanabenz (2,6-dichlorobenzylidene aminoguanidine acetate) is an orally bioavailable α2-adrenergic receptor agonist that has been used as an antihypertensive for decades. Recent studies demonstrated that guanabenz can regulate the ISR. Here, we assessed the effects of guanabenz on cellular and behavioral circadian rhythms using a multidisciplinary approach. We found that guanabenz can induce the ISR by increasing eIF2α phosphorylation in cultured fibroblasts as well as in the mouse brain. The hyperphosphorylation of eIF2α by guanabenz is associated with the shortened circadian period in cells and animals and the disruption of behavioral circadian rhythms in mice. Guanabenz administration disrupted circadian oscillations of the clock protein Per1 and Per2 in the mouse suprachiasmatic nucleus, the master pacemaker. These results uncover a significant yet previously unidentified role of guanabenz in regulating circadian rhythms and indicate that exacerbated ISR activation can impair the functions of the brain’s circadian clock by disrupting clock gene expression.
Amna Tahir, Muhammad Furqan Akhtar, Ammara Saleem, Muhammad Naveed, Basiru Olaitan Ajiboye, Fareeha Anwar, and Aslam Khan
Springer Science and Business Media LLC
Muhammad Naveed, Muhammad Azam, Nasrullah Khan, Muhammad Aslam, Muhammad Saleem, and Muhammad Saeed
Springer Science and Business Media LLC
AbstractIn this manuscript, we construct an attribute control chart (ACC) for the number of defective items using time-truncated life tests (TTLT) when the lifetime of a manufacturing item follows two lifetime data distributions: the half-normal distribution (HND) and the half-exponential power distribution (HEPD). To assess the potential of the proposed charts, necessary derivations are made to obtain the value of the average run length (ARL) when the production process is in-control and out-of-control. The performance of the presented charts is evaluated for different sample sizes, control coefficients, and truncated constants for shifted phases in terms of ARL. The behavior of ARLs is studied for the shifted process by introducing shifts in its parameters. The advantages of the proposed HEPD-based chart are discussed in the form of ARLs with HND and Exponential Distribution (ED) based ACCs under TTLT, showing the excellent assessment of the proposed chart. Additionally, the advantages of another proposed ACC using HND are compared with ED-based ACC, and the findings support the HND in the form of smaller ARLs. Finally, simulation testing and real-life implementation are also discussed for functional purposes.
Muhammad Naveed, Muhammad Azam, Muhammad Shujaat Nawaz, Muhammad Saleem, Muhammad Aslam, and Muhammad Saeed
Springer Science and Business Media LLC
AbstractThe control chart is the most valuable tool in the manufacturing process to track the output process in the industries. Quality specialists always want a visual framework that recognizes sustainable improvements in the monitoring processes. The efficiency of a control chart is increased by utilizing a memory-based estimator or by using any extra information relevant to the key variable. In this study, we present Extended EWMA (EEWMA) and EWMA based monitoring charts for observing the process location using moving average (MA) statistic under two different situations, i.e., when some extra information is known and unknown. We also propose an EEWMA control chart using Auxiliary Information. The output of these charts is evaluated and contrasted to the various existing charts on the basis of average run length (ARL). The comparison indicates that the proposed charts outperform rivals in identifying all types of shifts in the process location parameter. The implementation of these plans is also rendered to incorporate them in a practical situation.
Muhammad Safdar, Mehmet Ozaslan, Rebaz M. Mustafa, Shukur W. Smail, Samiha S. Khan, Muhammad Sajjad Khan, Muhammad Asad Akhtar, Hafiz Khawar Ali, Umair Younas, Muhammad Saeed,et al.
Elsevier BV
Muhammad Naveed, Lei Han, Sobia Noreen, Chaoyue Zhao, Gang Sheng, Lulu Xu, and Xiaohui Zhou
Neurotak Publishing
The dorsal root ganglia (DRG) neurons have long been studied to advance the understanding of sensory nerve function and growth. DRG neurons are also involved in determining the fundamental mechanisms of neurodegenerative and painful disorders of the peripheral nervous system. To explore the simple methods of rapid and accurate removal of DRG in anesthetized rats with the naked eye without destroying the spinal column or blood circulation. Male Wistar rats were fixed on the operating table, lumbar DRG was removed, and sufficient DRG neurons were harvested without microscopic equipment. At the same time, the procedure was accomplished without disruption to breathing and circulation. These approaches reduce the time required for DRG collection, thereby improving efficiency, and increasing the chances of generating healthy primary DRG cultures and reproducible experiments using DRG tissue.
Manthar Ali Mallah, Tahmina Soomro, Sobia Noreen, Mukhtiar Ali, Akriti Kafle, Nafeesa Khatoon, and Muhammad Naveed
Ovid Technologies (Wolters Kluwer Health)
Obesity has recently emerged as one of the most severe health concerns. Obesity is a key autonomous risk factor for heart failure and contributes to cardiovascular disease (CVD) risk factors such as hypertension, type 2 diabetes, and metabolic abnormalities. Obesity is caused by a metabolic imbalance, which occurs when calories burnt are fewer than the number of calories consumed. There are several pathways accountable for the adverse impacts of obesity on the cardiovascular system. Inflammatory cell infiltration develops in the adipose tissue, the pancreas, and other issues similar to the progression of obesity. Inflammation is triggered by immune cells that invade dysfunctional adipose tissue. The atherosclerotic inflammation phase, related to obesity, induces coronary calcification. Obesity is linked to elevated levels of leptin and high blood pressure. Leptin causes systemic vasoconstriction, sodium retention, and increased blood pressure by influencing the synthesis of nitric oxide and activating the sympathetic nervous system. Obesity is a well-known risk factor for CVD and is one of the leading causes of the greater risk of diseases, including dyslipidemia, hypertension, depression, metabolic syndrome, atrial fibrillation, and heart failure in adults and children. When used with dietary improvements, antiobesity drugs improve the probability of experiencing clinically healthy (5%) weight loss. This review aimed to address the consequences of obesity on cardiac structure and function, risk factors, the impact of the obesity paradox, pharmacological treatment strategies for managing and recommended exercise and diet.
Manthar Ali Mallah, Tahmina Soomro, Mukhtiar Ali, Sobia Noreen, Nafeesa Khatoon, Akriti Kafle, Feifei Feng, Wei Wang, Muhammad Naveed, and Qiao Zhang
Frontiers Media SA
Cardiovascular disease (CVD) has no socioeconomic, topographical, or sex limitations as reported by the World Health Organization (WHO). The significant drivers of CVD are cardio-metabolic, behavioral, environmental, and social risk factors. However, some significant risk factors for CVD (e.g., a pitiable diet, tobacco smoking, and a lack of physical activities), have also been linked to an elevated risk of cardiovascular disease. Lifestyles and environmental factors are known key variables in cardiovascular disease. The familiarity with smoke goes along with the contact with the environment: air pollution is considered a source of toxins that contribute to the CVD burden. The incidence of myocardial infarction increases in males and females and may lead to fatal coronary artery disease, as confirmed by epidemiological studies. Lipid modification, inflammation, and vasomotor dysfunction are integral components of atherosclerosis development and advancement. These aspects are essential for the identification of atherosclerosis in clinical investigations. This article aims to show the findings on the influence of CVD on the health of individuals and human populations, as well as possible pathology and their involvement in smoking-related cardiovascular diseases. This review also explains lifestyle and environmental factors that are known to contribute to CVD, with indications suggesting an affiliation between cigarette smoking, air pollution, and CVD.
Sobia Noreen, Jin-Xiang Ma, Muhammad Saeed, Fahad Pervaiz, Muhammad Farhan Hanif, Bilal Ahmed, Muhammad Irshad Farooq, Faizan Akram, Muhammad Safdar, Asadullah Madni,et al.
Springer Science and Business Media LLC
Muhammed Lamin Sambou, Juncheng Dai, Xiaoyu Zhao, Tongtong Hong, Til Bahadur Basnet, Gifty Marley, Alima Sambou, El Hafa Fadoua, and Muhammad Naveed
Frontiers Media SA
Objective: To examine the major determinants of VCT service uptake among adults in SSA.Methods: Electronic databases were searched to identify eligible English language publications. Reporting of the study selection procedure was done according to PRISMA and the selected articles were also critically appraised.Results: We found 8 significant determinants of VCT uptake among adults in SSA, such as less physical access [OR (Odds ratio): 0.77 (95% CI (Confidence interval): 0.62–0.96), p < 0.01], older age [OR: 1.36 (95% CI: 1.08–1.73), p < 0.01], higher education level [OR: 1.60 (95% CI: 1.24–2.05), p < 0.01], high knowledge of HIV and VCT awareness [OR: 1.40 (95% CI: 1.03–1.90), p < 0.01], unprotected sexual practices [OR: 1.75 (95% CI: 1.18–2.58), p < 0.01], discussion on HIV among partners and others [OR: 1.76 (95% CI: 1.10–2.81), p < 0.01], other STIs [OR: 1.40 (95% CI: 1.00–1.98), p < 0.01], and divorced/separated [OR: 1.39 (95% CI: 1.12–1.72), p < 0.01].Conclusion: This study showed that 8 determinants were significantly associated with VCT service uptake in SSA. Thus, HIV interventions and policy initiatives should be tailored to these determinants to ensure scale-up of VCT service uptake in SSA.
Muhammad Naveed, Li Changxing, Awais Ullah Ihsan, Muhammad Shumzaid, Asghar Ali Kamboh, Ali Asghar Mirjat, Muhammad saeed, Mirza Muhammad Faran Ashraf Baig, Hafiz Muhammad Zubair, Sobia Noreen,et al.
SAGE Publications
The assessment and management of urologic chronic pelvic pain syndrome (UCPPS), is controversial. It is classified by voiding symptoms, pelvic pain, and bladder pain, which is weekly treated, weekly understood, and bothersome. In the aspect of clinical efforts and research to help people with this syndrome have been hampered by the deficiency of a widely reliable, accepted, and a valuable tool to evaluate the patient symptoms and quality of life (QoL) impact. However, the etiology comes into sight is multifactorial, and available treatment options have been imprecise considerably in present years. We compiled the published literature on the assessment of the syndrome, a tentative role of pharmacological and non-pharmacological (conservative, alternative, and invasive therapy) interventions in eradicating the disease as well as improving symptoms. The previously published literature on animal models has established the association of immune systems in the etiology, pathogenesis, and progression of the disease. The UPOINT system for clinical phenotyping of UCPPS patients has six predefined domains that direct multimodal therapy, which would lead to significant symptom improvement in the medical field. The narrative review aims to scrutinize the fluctuating scientist’s views on the evaluation of patient and multimodal treatment of the UPOINT system.
Muhammad Naveed, Rahat Ullah, Sobia Noreen, Muhammad Saeed, Gang Sheng, Hafiz Muhammad Zubair, and Zhou Xiaohui
Elsevier BV
Sobia Noreen, Arslan Maqbool, Irsah Maqbool, Afifa Shafique, Muhammad Muzamil Khan, Yasmeen Junejo, Bilal Ahmed, Maryam Anwar, Asma Majeed, Muhammad Abbas,et al.
Elsevier BV
Manthar Ali Mallah, Li Changxing, Mukhtiar Ali Mallah, Sobia Noreen, Yang Liu, Muhammad Saeed, He Xi, Bilal Ahmed, Feifei Feng, Ali Asghar Mirjat,et al.
Elsevier BV
Manthar Ali Mallah, Li Changxing, Mukhtiar Ali Mallah, Muhammad Naveed, Yang Liu, Sobia Noreen, He Xi, Wei Wang, Feifei Feng, and Qiao Zhang
Elsevier BV
Waqas Nawaz, Muhammad Naveed, Jing Zhang, Sobia Noreen, Muhammad Saeed, Kiganda Raymond Sembatya, Awais Ullah Ihsan, Imran Shair Mohammad, Gang Wang, and Xiaohui Zhou
Springer Science and Business Media LLC
AbstractThis study aims to evaluate the feasibility and cardio-protective effects of biocompatible silicon-built restraint device (ASD) in the rat’s heart failure (HF) model. The performance and compliance characteristics of the ASD device were assessed in vitro by adopting a pneumatic drive and ball burst test. Sprague-Dawley (SD) rats were divided into four groups (n = 6); control, HF, HF + CSD, and HF + ASD groups, respectively. Heart failure was developed by left anterior descending (LAD) coronary artery ligation in all groups except the control group. The ASD and CSD devices were implanted in the heart of HF + ASD and HF + CSD groups, respectively. The ASD’s functional and expansion ability was found to be safe and suitable for attenuating ventricular remodeling. ASD-treated rats showed normal heart rhythm, demonstrated by smooth -ST and asymmetrical T-wave. At the same time, hemodynamic parameters of the HF + ASD group improved systolic and diastolic functions, reducing ventricular wall stress, which indicated reverse remodeling. The BNP values were reduced in the HF + ASD group, which confirmed ASD feasibility and reversed remodeling at a molecular level. Furthermore, the HF + ASD group with no fibrosis suggests that ASD has significant curative effects on the heart muscles. In conclusion, ASD was found to be a promising restraint therapy than the previously standard restraint therapies.
Han Wei, Xiaojun Xin, Jing Zhang, Qingya Xie, Muhammad Naveed, Chen Kaiyan, and Pingxi Xiao
Springer Science and Business Media LLC
Muhammed Lamin Sambou, Xiaoyu Zhao, Tongtong Hong, Muhammad Naveed, Alima Sambou, Fadoua El Hafa, TIl B. Basnet, and Juncheng Dai
Springer Science and Business Media LLC
Chang-Xing Li, Sobia Noreen, Li-Xue Zhang, Muhammad Saeed, Pei-Feng Wu, Muhammad Ijaz, Dong-Fang Dai, Irsah Maqbool, Asadullah Madni, Faizan Akram,et al.
Elsevier BV
Qin-Yuan Li, Mahzaib Munawar, Muhammad Saeed, Ji-Qiang Shen, Muhammad Sajjad Khan, Sobia Noreen, Mahmoud Alagawany, Muhammad Naveed, Asadullah Madni, and Chang-Xing Li
Frontiers Media SA
Health consciousness and increased knowledge about the side effects of synthetic drugs have enhanced interest in traditional medicines. Medicinal plants offer cures for various diseases, leading to improved living standards. This has brought ethnomedicinal studies into the spotlight and increased demand for herb-based medicines. Citrullus colocynthis is an herbaceous plant containing an abundance of nutrients that play a key role in the improvement of wellbeing. C. colocynthis has many biological properties, such as antioxidative, hypoglycemic, antibacterial, anti-cancerous, anti-inflammatory, analgesic, gastrointestinal tract, reproduction, protection, anti-microbial, antidiabetic, hypolipidemic, antineoplastic, profibrinolytic, anti-allergic, pesticidal, and immune-stimulatory. There are numerous bioactive compounds like cucurbitacin, flavonoids, and polyphenols in C. colocynthis that give it medicinal properties. Herein, we have extensively compiled, reviewed, and analyzed significant information on C. colocynthhis from the best published available evidence in PubMed, Scopus (Embase), Web of Science (Web of Knowledge), Cochrane Library, and Google Scholar, etc. Scientific literature evidenced that owing to the bioactive constituents, including cucurbitacin, polyphenols, flavonoids, and other potent molecules, C. colocynthis has many pharmacological and physiological functions. It possesses multi-beneficial applications in treating various disorders of humans and animals. So, the primary purpose of this comprehensive review is to provide an overview of the findings of positive impacts and risks of C. colocynthis consumption on human health, especially in poultry and veterinary fields. In the future, this narrative article will be aware of discoveries about the potential of this promising natural fruit and its bioactive compounds as the best nutraceuticals and therapeutic drugs in veterinary and human medicine.
Jing Zhang, Qi-Gang Zhou, Muhammad Naveed, Lian-Di Li, Gang Sheng, Zi-Wei Du, Ya-Ping Zhou, Sun Nan, and Ming-Yi Zhu
Bentham Science Publishers Ltd.
: Major depressive disorder (MDD) is one of the foremost causes of disability and premature death worldwide. Although the available antidepressants are effective and well tolerated, they also have many limitations. Therapeutic advances in developing a new drug's ultimate relation between MDD and chronobiology, which targets the circadian rhythm, led to a renewed focus on psychiatric disorders. In order to provide a critical analysis about antidepressant properties of agomelatine, a detailed PubMed (Medline), Scopus (Embase), Web of Science (Web of Knowledge), Cochrane Library, Google Scholar, and PsycInfo search was performed using the following keywords: melatonin analog, agomelatine, safety, efficacy, adverse effects, pharmacokinetics, pharmacodynamics, circadian rhythm, sleep disorders, neuroplasticity, MDD, bipolar disorder, anhedonia, anxiety, generalized anxiety disorder (GAD), and mood disorders. Agomelatine is a unique melatonin analog with antidepressant properties and a large therapeutic index that improves clinical safety. Published articles revealed that agomelatine is a melatonin receptors (MT1 and MT2) agonist and 5HT2C receptor antagonist. The effects receptors' on melatonin receptors enable the resynchronization of irregular circadian rhythms with beneficial effects on sleep architectures. In this way, agomelatine is accredited for its unique mode of action, which helps to exert antidepressant effects and resynchronize the sleep-wake cycle. To sum up, an agomelatine has not only antidepressant properties but also has anxiolytic effects.