Laura Guimaraes

Scopus Publications

Ocean Literacy in Portugal: Three Decades of Experience and Innovative Educational Initiatives Supporting the Ocean Decade
Zara Teixeira, Raquel L. Costa, Patrícia Conceição, Cláudia Faria, Laura Guimarães
Sustainable Development Goals Series, 2026
Portugal has been at the forefront of Ocean Literacy (OL) initiatives in Europe, pioneering efforts to promote knowledge and awareness of Ocean-related issues. Over three decades, many OL educational initiatives have been implemented. Despite these efforts, a significant gap remains in our baseline understanding of the reach and impact of these initiatives, highlighting a need for comprehensive assessment. This chapter aims to deepen scientific understanding and provide actionable insights on what has been done and lessons learned for the future. Overall, 114 initiatives were identified and implemented in Portugal since 1990. These initiatives were led by the academia, governmental agencies, non-governmental organisations (NGOs), the economic sector and private foundations. To achieve this, a quantitative and qualitative analysis was conducted. The target audience were students, teachers and the broader community. The study offers a comprehensive review of these OL initiatives, the implementation challenges they faced and the inspiring solutions proposed, serving as a call to action for a unified strategy to cultivate future generations of informed Ocean stewards.
Barcoding the Caatinga biome bees: a practical review
Pedro Rodrigues, Cláudia Teixeira, Laura Guimarães, Nuno G. C. Ferreira
Molecular Biology Reports, 2025
Bees play a critical role as pollinators in ecosystem services, contributing significantly to the sexual reproduction and diversity of plants. The Caatinga biome in Brazil, home to around 200 bee species, provides an ideal habitat for these species due to its unique climate conditions. However, this biome faces threats from anthropogenic processes, making it urgent to characterise the local bee populations efficiently. Traditional taxonomic surveys for bee identification are complex due to the lack of suitable keys and expertise required. As a result, molecular barcoding has emerged as a valuable tool, using genome regions to compare and identify bee species. However, little is known about Caatinga bees to develop these molecular tools further. This study addresses this gap, providing an updated list of 262 Caatinga bee species across 86 genera and identifying ~ 40 primer sets to aid in barcoding these species. The findings highlight the ongoing work needed to fully characterise the Caatinga biome’s bee distribution and species or subspecies to support more effective monitoring and conservation efforts.
Beyond opioid and SNRI-like actions: Proteomic insights into the effects of tramadol and O-desmethyltramadol in zebrafish larvae
Pedro Rodrigues, Mário Jorge Araújo, Alexandre Campos, Maria V. Turkina, Luís Oliva-Teles, António Paulo Carvalho, Laura Guimarães
Comparative Biochemistry and Physiology Part D Genomics and Proteomics, 2025
The presence of pharmaceuticals in natural habitats is an increasing concern. In particular, the antidepressant tramadol (TRA) and its metabolite o -desmethyltramadol (OTRA) have become ubiquitous compounds in aquatic ecosystems. However, investigation of their impact on fish, particularly on their proteome, still needs attention. Therefore, this work assesses the alterations in the proteome of zebrafish larvae caused by TRA or OTRA exposure. Zebrafish larvae (0–3 h post-fertilization, hpf) were exposed to 0.1 or 100 μg/L of TRA or OTRA until reaching 168 hpf. The larvae proteome was then investigated through shotgun proteomics, employing the filter-aided sample preparation method (FASP) followed by high-throughput LC-MS/MS analysis. Coupling mass spectrometry quantification with a saturated orthogonal multiple linear regression analysis provided identification of differentially expressed proteins (DEPs). Finally, the functional analysis of these DEPs was performed with STRING-DB online tool to identify possible molecular pathways affected by the treatments. A total of 162 DEPs were identified, with the highest number observed in larvae exposed to the lower TRA concentration. These highlights possible non-monotonic responses and supports previously described effects for other endpoints, which may affect the serotonergic, noradrenergic and opioid systems. The Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis also indicated putative alterations in metabolic pathways e.g., Glycolysis/Gluconeogenesis, Tricarboxylic Acid Cycle (TCA), Oxidative phosphorylation, Pyruvate metabolism, and Carbon metabolism. Our results suggest that TRA and OTRA exposure may impact vital biological processes in fish larvae, emphasizing the need for adequate integrated monitoring of tramadol, its metabolites, and effects in aquatic ecosystems. • 162 differentially expressed proteins between exposed and control larvae • Downregulation was found for most of the 162 differentially expressed proteins • Potential non-monotonic responses were found for tramadol • A total of 12 KEGGs were affected by tramadol and o -desmethyltramadol exposure • All affected KEGGs were related with vital biological processes in fish larvae
An augmented reality board game to work ocean literacy dimensions
Rui Leitão, Shige Yao, Laura Guimarães
Education and Information Technologies, 2025
Over the past decade, research has stressed the necessity of increasing ocean teaching in formal and informal education by addressing ocean literacy dimensions. Although board games have emerged as an affordable and accessible option for immersive learning experiences, limited empirical evidence demonstrates their effectiveness in enhancing students' understanding of ocean-related concepts. Board games can encourage face-to-face interactions among peers or teams by combining tangible materials with turn-taking modes and promote students’ engagement with multiple aspects of ocean literacy. The present work aimed to develop an augmented reality (AR) game-based educational tool (The Blue Bounty) to inform about the ocean and explore how this could help improve engagement with different ocean dimensions. The development process followed a co-design approach with university students, based on the Design, Play and Experience (DPE) framework. The game was used in an intervention to assess its ability to address six relevant ocean literacy dimensions in a pre/post assessment design. The findings from the game activity show that the research tool has the potential to significantly increase various dimensions, including knowledge acquisition, awareness enhancement, communication skills, attitude formation, activism engagement, and behaviour change, more than a control traditional lecture. Each dimension is impacted differently, highlighting the multifaceted benefits of integrating these activities into formal and informal environments. Additionally, the results suggest that increasing knowledge may have a positive impact on awareness, communication, attitude, activism and the behaviour layer. Discussion includes implications for the development of more engaging environmental educational tools, including the design, implementation, and measurable outcomes.
Baseline Raman Spectral Fingerprints of Zebrafish Embryos and Larvae
Isabel Oliveira Abreu, Cláudia Teixeira, Rui Vilarinho, A. Cristina S. Rocha, Joaquim Agostinho Moreira, Luís Oliva-Teles, Laura Guimarães, António Paulo Carvalho
Biosensors, 2024
As a highly sensitive vibrational technique, Raman spectroscopy (RS) can provide valuable chemical and molecular data useful to characterise animal cell types, tissues and organs. As a label-free, rapid detection method, RS has been considered a valuable asset in forensics, biology and medicine. The technique has been applied to zebrafish for various purposes, including physiological, biochemical or bioaccumulation analyses. The available data point out its potential for the early diagnosis of detrimental effects elicited by toxicant exposure. Nevertheless, no baseline spectra are available for zebrafish embryos and larvae that could allow for suitable planning of toxicological assessments, comparison with toxicant-elicited spectra or mechanistic understanding of biochemical and physiological responses to the exposures. With this in mind, this work carried out a baseline characterisation of Raman spectra of zebrafish embryos and larvae throughout early development. Raman spectra were recorded from the iris, forebrain, melanocytes, heart, muscle and swim bladder between 24 and 168 h post-fertilisation. A chemometrics approach, based on partial least-squares discriminant analysis (PLS-DA), was used to obtain a Raman characterisation of each tissue or organ. In total, 117 Raman bands were identified, of which 24 were well represented and, thus, retained in the data analysed. Only three bands were found to be common to all organs and tissues. The PLS-DA provided a tentative Raman spectral fingerprint typical of each tissue or organ, reflecting the ongoing developmental dynamics. The bands showed frequencies previously assigned to collagen, cholesterol, various essential amino acids, carbohydrates and nucleic acids.
Potential of nature-based solutions to reduce antibiotics, antimicrobial resistance, and pathogens in aquatic ecosystems. a critical review
Edward J. Pastor-López, Mònica Escolà, Vaidotas Kisielius, Carlos A. Arias, Pedro N. Carvalho, Ana M. Gorito, Sandra Ramos, Vânia Freitas, Laura Guimarães, C. Marisa R. Almeida, Jochen A. Müller, Eberhard Küster, R.M. Kilian, Abdoulaye Diawara, Sidy Ba, Víctor Matamoros
Science of the Total Environment, 2024
This comprehensive scientific review evaluates the effectiveness of nature-based solutions (NBS) in reducing antibiotics (ABs), combating antimicrobial resistance (AMR), and controlling pathogens in various aquatic environments at different river catchment levels. It covers conventional and innovative treatment wetland configurations for wastewater treatment to reduce pollutant discharge into the aquatic ecosystems as well as exploring how river restoration and saltmarshes can enhance pollutant removal. Through the analysis of experimental studies and case examples, the review shows NBS's potential for providing sustainable and cost-effective solutions to improve the health of aquatic ecosystems. It also evaluates the use of diagnostic indicators to predict NBS effectiveness in removing specific pollutants such as ABs and AMR. The review concludes that NBS are feasible for addressing the new challenges stemming from human activities such as the presence of ABs, AMR and pathogens, contributing to a better understanding of NBS, highlighting success stories, addressing knowledge gaps, and providing recommendations for future research and implementation.
Constructed wetlands as nature based solutions – hands-on activities to highlight their potential to minimize ocean pollution
C. Marisa R. Almeida, Tomé Azevedo, Laura Guimarães
Journal of Coastal Conservation, 2024
This work presents an engaging hands-on activity designed to teach school students about nature based solutions (NBS) and their role in achieving high-quality water systems within a sustainable circular economy. Through this activity, students actively participate in building a small constructed wetland (CW) and test its effectiveness under various contamination scenarios. The activity was tested with school teachers, undergoing refinements based on their feedback. This iterative development process has ensured the activity’s effectiveness in engaging both school students and the public. Further, the CW model can be scaled-up for specific school projects focused on improving water quality. This activity offers valuable opportunities to enhance ocean literacy, promote understanding on NBS and raise awareness about aquatic ecosystems contamination and the importance of environmental sustainability.
Ecotoxicological Effects of Potassium Dichromate on the Tadpole Shrimp Triops longicaudatus
André Carido Pereira, Aurélia Saraiva, Luís Oliva-Teles, Laura Guimarães, António Paulo Carvalho
Animals, 2024
The tadpole shrimp Triops longicaudatus is a freshwater crustacean with fast embryonic and larval development, short life cycle, and high fecundity. They are very active swimmers of a reasonable size, easy to spot and record. Such characteristics make it a promising candidate as an experimental model in ecotoxicology to evaluate the effects of aquatic pollutants, particularly using its locomotor behavior as an endpoint. To evaluate the sensitivity of T. longicaudatus and develop endpoints of interest, we conducted exposure experiments with lethal and sub-lethal concentrations of potassium dichromate, a compound known for its ecotoxicological importance and as a hexavalent chromium source. The endpoints evaluated were mortality, growth, sexual maturation, reproductive output, cholinesterase activity and locomotor/swimming behavior. The 96 h median lethal concentration was found to be 65 µg/L. Furthermore, exposure to potassium dichromate at higher concentrations had a significant negative impact on the growth rate of T. longicaudatus in terms of both body mass and length. The time for maturation was also delayed at higher concentrations. In addition, locomotor behavior allowed for the discrimination of all tested chromium concentrations and the control group and from each other, proving to be the most sensitive endpoint. Overall, the data support the potential of T. longicaudatus as a model for ecotoxicity testing, using apical endpoints with impact at the population level; in particular, results suggest that behavior assessments in this species might be useful for detecting hazardous compounds in environmental monitoring of freshwater ecosystems.
Sensitivity of Triops longicaudatus Locomotor Behaviour to Detect Short Low-Level Exposure to Pollutants
Laura Guimarães, António Paulo Carvalho, Pedro Ribeiro, Cláudia Teixeira, Nuno Silva, André Pereira, João Amorim, Luís Oliva-Teles
Water Switzerland, 2024
Triops longicaudatus is a crustacean typically inhabiting temporary freshwater bodies in regions with a Mediterranean climate. These crustaceans are easily maintained in the laboratory and show a set of biological features that make them good candidates for diagnosing environmental quality and health. However, information about their responses to environmental contamination is scarce. This study characterised the locomotor responses of juvenile and adult/mature T. longicaudatus to low concentrations of five model toxicants upon a very short 1.5 h exposure: tributyltin, mercury, lindane, sodium hypochlorite and formaldehyde. A video-tracking system was used to record the locomotor behaviour. The data were analysed with an artificial neural network to identify distinct behaviours, followed by Chi-square and Correspondence analysis to characterise the response to each toxicant. The results showed that T. longicaudatus is sensitive to aquatic contamination, particularly sodium hypochlorite. Six behaviour types were defined, which allowed for the characterisation and discrimination of the test toxicants. The results support the need for more investigation into this species and its behaviour types as an alternative to animal testing and the more apical and often invasive endpoints commonly recommended in standard guidelines.
Toxic Relationships: Prediction of TBT’s Affinity to the Ecdysteroid Receptor of Triops longicaudatus
Nuno Gonçalo de Carvalho Ferreira, Adriano Chessa, Isabel Oliveira Abreu, Luís Oliva Teles, Peter Kille, António Paulo Carvalho, Laura Guimarães
Toxics, 2023
Tributyltin (TBT) is a biocide introduced in the 1960s in antifouling paints. Despite legislation banning its use, its persistence in the environment still causes significant harm to organisms. Tributyltin is a ligand of retinoid X receptors (RXR) and ecdysteroid receptors (EcRs), which in arthropods act as homologs of RXR. Focusing on Metazoan species, this study used genomic and proteomic information from different sources to compare their three-dimensional structure, phylogenetic distribution, and amino acid sequence alterations. The objective was to identify possible patterns that relate organisms’ sensitivity to TBT using the species Triops longicaudatus as the basis for the comparisons. The results showed great conservation of this protein across several species when comparing the interaction amino acids described to RXR (an EcR analog) in Homo sapiens. The three-dimensional comparison of RXR showed little conformational variation between different sequences by maintaining the interaction pocket. As for the Species Sensitivity Distribution (SSD) curve, an HC05 = 0.2649 [0.0789–0.7082] µg/L was obtained with no specific distribution between the different taxa. Protein-ligand docking analysis was then used to confirm the SSD curve ranking of species. Still, the results showed an opposite trend that may be related, for example, to differences in the LC50 values used in the calculations. This study serves as the first step for applying bioinformatics techniques to produce information that can be used as an alternative to animal or cellular experimentation. These techniques could be adapted to various chemicals and proteins, allowing for observations in a shorter timeframe and providing information on a broader spectrum.
Carbamazepine, venlafaxine, tramadol, and their main metabolites: Toxicological effects on zebrafish embryos and larvae
P. Rodrigues, L. Guimarães, AP. Carvalho, L. Oliva-Teles
Journal of Hazardous Materials, 2023
Editorial: Seafood: nutrition savior or safety hazard?
Sara Sousa, Maria Luz Maia, Laura Guimarães, Valentina F. Domingues
Frontiers in Nutrition, 2023
Occurrence of Pharmaceutical and Pesticide Transformation Products in Freshwater: Update on Environmental Levels, Toxicological Information and Future Challenges
P. Rodrigues, L. Oliva-Teles, L. Guimarães, A. P. Carvalho
Reviews of Environmental Contamination and Toxicology, 2022
Thermochemical Conversion Processes as a Path for Sustainability of the Tire Industry: Carbon Black Recovery Potential in a Circular Economy Approach
Leonel J. R. Nunes, Laura Guimarães, Miguel Oliveira, Peter Kille, Nuno G. C. Ferreira
Clean Technologies, 2022
Novel Approach to Freshwater Diatom Profiling and Identification Using Raman Spectroscopy and Chemometric Analysis
Raquel Pinto, Rui Vilarinho, António Paulo Carvalho, Joaquim Agostinho Moreira, Laura Guimarães, Luís Oliva-Teles
Water Switzerland, 2022
Antibiotics removal from aquaculture effluents by ozonation: chemical and toxicity descriptors
Ana M. Gorito, Ana R. Lado Ribeiro, Pedro Rodrigues, M. Fernando R. Pereira, Laura Guimarães, C. Marisa R. Almeida, Adrián M.T. Silva
Water Research, 2022
Environmental diagnosis with Raman Spectroscopy applied to diatoms
Luís Oliva-Teles, Raquel Pinto, Rui Vilarinho, António Paulo Carvalho, J. Agostinho Moreira, Laura Guimarães
Biosensors and Bioelectronics, 2022
Differential Molecular Responses of Zebrafish Larvae to Fluoxetine and Norfluoxetine
Pedro Rodrigues, Virgínia Cunha, Marta Ferreira, Maria Armanda Reis-Henriques, Luís Oliva-Teles, Laura Guimarães, António Paulo Carvalho
Water Switzerland, 2022
A systematic evaluation of game elements effects on students’ motivation
Rui Leitão, Martin Maguire, Sarah Turner, Laura Guimarães
Education and Information Technologies, 2022
Ocean literacy gamified: A systematic evaluation of the effect of game elements on students’ learning experience
Rui Leitão, Martin Maguire, Sarah Turner, Francisco Arenas, Laura Guimarães
Environmental Education Research, 2022
Dietary tryptophan supplementation does not affect growth but increases brain serotonin level and modulates the expression of some liver genes in zebrafish (Danio rerio)
Cláudia Teixeira, Pedro Rodrigues, Paula Serrão, Luís Figueira, Laura Guimarães, Luís Oliva Teles, Helena Peres, António Paulo Carvalho
Fish Physiology and Biochemistry, 2021
Microplastics as a vehicle of exposure to chemical contamination in freshwater systems: Current research status and way forward
Miriam Lena Eder, Luis Oliva-Teles, Raquel Pinto, António Paulo Carvalho, C. Marisa R. Almeida, Romana Hornek-Gausterer, Laura Guimarães
Journal of Hazardous Materials, 2021
Raman spectroscopy applied to diatoms (microalgae, Bacillariophyta): Prospective use in the environmental diagnosis of freshwater ecosystems
Raquel Pinto, Rui Vilarinho, António Paulo Carvalho, J. Agostinho Moreira, Laura Guimarães, Luís Oliva-Teles
Water Research, 2021
Assessing contamination from maritime trade and transportation on Iberian waters: Impact on Platichthys flesus
A. Cristina S. Rocha, Catarina Teixeira, C. Marisa R. Almeida, M. Clara P. Basto, M.A. Reis-Henriques, Laura Guimarães, Marta Ferreira
Environmental and Sustainability Indicators, 2021
Assessing contamination from maritime trade and transportation on Iberian waters: Impact on Mytilus sp
A. Cristina S. Rocha, Catarina Teixeira, C. Marisa R. Almeida, M. Clara P. Basto, M.A. Reis-Henriques, Marta Ferreira, Laura Guimarães
Ecological Indicators, 2021
Occurrence of Levonorgestrel in Water Systems and Its Effects on Aquatic Organisms: A Review
Ana Lourdes Oropesa, Laura Guimarães
Reviews of Environmental Contamination and Toxicology, 2021
Correction to: Occurrence of levonorgestrel in water systems and its effects on aquatic organisms: A review (reviews of environmental contamination and toxicology, 10.1007/398_2020_44)
Ana Lourdes Oropesa, Laura Guimarães
Reviews of Environmental Contamination and Toxicology, 2021
Fostering Ocean-Literate Generations: The Portuguese Blue School
Raquel L. Costa, Bernardo Mata, Fernanda Silva, Patrícia Conceição, Laura Guimarães
Key Challenges in Geography, 2021
Norfluoxetine and venlafaxine in zebrafish larvae: Single and combined toxicity of two pharmaceutical products relevant for risk assessment
P. Rodrigues, V. Cunha, L. Oliva-Teles, M. Ferreira, L. Guimarães
Journal of Hazardous Materials, 2020
Effects of norfluoxetine and venlafaxine in zebrafish larvae: Molecular data
Pedro Rodrigues, Virgínia Cunha, Luís Oliva-Teles, Marta Ferreira, Laura Guimarães
Data in Brief, 2020
Can sustainable water monitoring be a reality?
Tahmina Ajmal, Laura Guimarães, Bettina Genthe, Ulrike Rivett
Iop Conference Series Earth and Environmental Science, 2020
Integrated Multi-Trophic Aquaculture: A Laboratory and Hands-on Experimental Activity to Promote Environmental Sustainability Awareness and Value of Aquaculture Products
Marta Correia, Isabel Costa Azevedo, Helena Peres, Rui Magalhães, Aires Oliva-Teles, Cristina Marisa Ribeiro Almeida, Laura Guimarães
Frontiers in Marine Science, 2020
Embryotoxicity and molecular alterations of fluoxetine and norfluoxetine in early zebrafish larvae
Pedro Rodrigues, V. Cunha, M. Ferreira, Laura Guimarães
Advances in Science Technology and Innovation, 2020
Performance of electro-fenton water treatment technology in decreasing zebrafish embryotoxicity elicited by a mixture of organic contaminants
João Amorim, Carlos Pinheiro, Isabel Abreu, Pedro Rodrigues, M. Ángeles Sanromán, Emílio Rosales, Marta Pazos, António Soares, Cristina Delerue-Matos, Aurélia Saraiva, Luís Oliva-Teles, António Paulo Carvalho, Laura Guimarães
Advances in Science Technology and Innovation, 2020
Assessing the ecological status of small Mediterranean rivers using benthic macroinvertebrates and macrophytes as indicators
Carolina Rodrigues, Paulo Alves, Ana Bio, Cristiana Vieira, Laura Guimarães, Carlos Pinheiro, Natividade Vieira
Environmental Monitoring and Assessment, 2019
Combining biomarker and community approaches using benthic macroinvertebrates can improve the assessment of the ecological status of rivers
Carolina Rodrigues, Laura Guimarães, Natividade Vieira
Hydrobiologia, 2019
Assessing the ecological status of fluvial ecosystems employing a macroinvertebrate multi-taxon and multi-biomarker approach
Carolina Rodrigues, Ana Bio, Laura Guimarães, Virgínia C. Fernandes, Cristina Delerue-Matos, Natividade Vieira
Environmental Monitoring and Assessment, 2019
Lymnaea stagnalis as a freshwater model invertebrate for ecotoxicological studies
João Amorim, Isabel Abreu, Pedro Rodrigues, Diogo Peixoto, Carlos Pinheiro, Aurélia Saraiva, António Paulo Carvalho, Laura Guimarães, Luis Oliva-Teles
Science of the Total Environment, 2019
Assessment of urban groundwater: towards integrated hydrogeological and effects-based monitoring
Laura Guimarães, Lúcia Guilhermino, Maria José Afonso, José Manuel Marques, Helder I. Chaminé
Sustainable Water Resources Management, 2019
Toxicogenomics of gold nanoparticles in a marine fish: Linkage to classical biomarkers
Mariana Teles, Felipe E. Reyes-López, Joan C. Balasch, Asta Tvarijonaviciute, Laura Guimarães, Miguel Oliveira, Lluis Tort
Frontiers in Marine Science, 2019
MALIA: A project to raise awareness on Marine Litter in the Atlantic and Mediterranean
Teresita Gravina, Michele Zucali, Alessandra Iero, Juan Diego Lopez Giraldo, Alberto Ruiz, Iolanda Borges, Costantina Cossu, Christos Maratheftis, Markella Papanicolaou, C. Marisa R. Almeida, Laura Guimarães
Rendiconti Online Societa Geologica Italiana, 2019
Data for the analysis of interactive multibiomarker responses of a marine crustacean to long-term exposure to aquatic contaminants
Isabel Oliveira Abreu, Catarina Monteiro, A. Cristina S. Rocha, M.A. Reis-Henriques, Catarina Teixeira, Maria Clara Pires Basto, Marta Ferreira, C. Marisa R. Almeida, Luís Oliva-Teles, Laura Guimarães
Data in Brief, 2018
Multibiomarker interactions to diagnose and follow-up chronic exposure of a marine crustacean to Hazardous and Noxious Substances (HNS)
Isabel Oliveira Abreu, Catarina Monteiro, A. Cristina S. Rocha, Maria Armanda Reis-Henriques, Catarina Teixeira, Maria Clara Pires Basto, Marta Ferreira, C. Marisa R. Almeida, Luís Oliva-Teles, Laura Guimarães
Environmental Pollution, 2018
The last frontier: Coupling technological developments with scientific challenges to improve hazard assessment of deep-sea mining
M.M. Santos, P.A.S. Jorge, J. Coimbra, C. Vale, M. Caetano, L. Bastos, I. Iglesias, L. Guimarães, M.A. Reis-Henriques, L.O. Teles, M.N. Vieira, J. Raimundo, M. Pinheiro, V. Nogueira, R. Pereira, T. Neuparth, M.C. Ribeiro, E. Silva, L. Filipe C. Castro
Science of the Total Environment, 2018
Seasonal variation in biomarker responses of Donax trunculus from the Gulf of Annaba (Algeria): Implication of metal accumulation in sediments
Akila Amira, Isma Merad, C. Marisa R. Almeida, Laura Guimarães, Nourredine Soltani
Comptes Rendus Geoscience, 2018
Toxic potential of organic constituents of submicron particulate matter (PM1) in an urban road site (Barcelona)
Sofia R. Mesquita, Barend L. van Drooge, Manuel Dall’Osto, Joan O. Grimalt, Carlos Barata, Natividade Vieira, Laura Guimarães, Benjamin Piña
Environmental Science and Pollution Research, 2017
Linking cortisol response with gene expression in fish exposed to gold nanoparticles
M. Teles, A.M.V.M. Soares, L. Tort, L. Guimarães, M. Oliveira
Science of the Total Environment, 2017
Changes in stroke incidence, outcome, and associated factors in Porto between 1998 and 2011
Manuel Correia, Rui Magalhães, Rui Felgueiras, Cláudia Quintas, Laura Guimarães, Maria C Silva
International Journal of Stroke, 2017
Environmental groundwater vulnerability assessment in urban water mines (porto, NW Portugal)
Maria Afonso, Liliana Freitas, Alcides Pereira, Luís Neves, Laura Guimarães, Lúcia Guilhermino, Bernhard Mayer, Fernando Rocha, José Marques, Helder Chaminé
Water Switzerland, 2016
Alterations in gene expression levels provide early indicators of chemical stress during Xenopus laevis embryo development: A case study with perfluorooctane sulfonate (PFOS)
Laura San-Segundo, Laura Guimarães, Carlos Fernández Torija, Eulalia M. Beltrán, Lúcia Guilhermino, María Victoria Pablos
Ecotoxicology and Environmental Safety, 2016
Toxicity assessment of atmospheric particulate matter in the Mediterranean and Black Seas open waters
Sofia R. Mesquita, Jordi Dachs, Barend L. van Drooge, Javier Castro-Jiménez, Laia Navarro-Martín, Carlos Barata, Natividade Vieira, Laura Guimarães, Benjamin Piña
Science of the Total Environment, 2016
Toxicity of seven priority hazardous and noxious substances (HNSs) to marine organisms: Current status, knowledge gaps and recommendations for future research
A. Cristina S. Rocha, Maria Armanda Reis-Henriques, Victor Galhano, Marta Ferreira, Laura Guimarães
Science of the Total Environment, 2016
The use of biomarkers as integrative tools for transitional water bodies monitoring in the Water Framework Directive context - A holistic approach in Minho river transitional waters
R. Capela, J. Raimundo, M.M. Santos, M. Caetano, C. Micaelo, C. Vale, L. Guimarães, M.A. Reis-Henriques
Science of the Total Environment, 2016
The mammalian "obesogen" tributyltin targets hepatic triglyceride accumulation and the transcriptional regulation of lipid metabolism in the liver and brain of zebrafish
Angeliki Lyssimachou, Joana G. Santos, Ana André, Joana Soares, Daniela Lima, Laura Guimarães, C. Marisa R. Almeida, Catarina Teixeira, L. Filipe C. Castro, Miguel M. Santos
Plos One, 2015
Differential embryotoxicity of the organic pollutants in rural and urban air particles
Sofia R. Mesquita, Barend L. van Drooge, Eva Oliveira, Joan O. Grimalt, Carlos Barata, Natividade Vieira, Laura Guimarães, Benjamin Piña
Environmental Pollution, 2015
Assessment of groundwater contamination in an agricultural peri-urban area (NW Portugal): an integrated approach
M. F. Barroso, M. J. Ramalhosa, A. Olhero, M. C. Antão, M. F. Pina, L. Guimarães, J. Teixeira, M. J. Afonso, C. Delerue-Matos, H. I. Chaminé
Environmental Earth Sciences, 2015
N-acetyl-β-d-glucosaminidase activity in feral Carcinus maenas exposed to cadmium
Sofia Raquel Mesquita, Şeyda Fikirdeşici Ergen, Aurélie Pinto Rodrigues, M. Teresa Oliva-Teles, Cristina Delerue-Matos, Laura Guimarães
Aquatic Toxicology, 2015
Sertraline accumulation and effects in the estuarine decapod Carcinus maenas: Importance of the history of exposure to chemical stress
Aurélie P. Rodrigues, Lúcia H.M.L.M. Santos, Maria João Ramalhosa, Cristina Delerue-Matos, Laura Guimarães
Journal of Hazardous Materials, 2015
Joint effects of salinity and the antidepressant sertraline on the estuarine decapod Carcinus maenas
Aurélie P. Rodrigues, Lúcia H.M.L.M. Santos, Maria Teresa Oliva-Teles, Cristina Delerue-Matos, Laura Guimarães
Aquatic Toxicology, 2014
Toxicity of atmospheric particle-bound PAHs: an environmental perspective
Sofia Raquel Mesquita, Barend L. van Drooge, Carlos Barata, Natividade Vieira, Laura Guimarães, Benjamin Piña
Environmental Science and Pollution Research, 2014
Integrated biomarker responses of an estuarine invertebrate to high abiotic stress and decreased metal contamination
Aurélie Pinto Rodrigues, Teresa Oliva–Teles, Sofia Raquel Mesquita, Cristina Delerue–Matos, Laura Guimarães
Marine Environmental Research, 2014
Cumulative effects of exposure to cyanobacteria bloom extracts and benzo[a]pyrene on antioxidant defence biomarkers in Gammarus oceanicus (Crustacea: Amphipoda)
Raisa Turja, Laura Guimarães, Anna Nevala, Harri Kankaanpää, Samuli Korpinen, Kari K. Lehtonen
Toxicon, 2014
Toxic assessment of urban atmospheric particle-bound PAHs: Relevance of composition and particle size in Barcelona (Spain)
Sofia Raquel Mesquita, Barend L. van Drooge, Cristina Reche, Laura Guimarães, Joan O. Grimalt, Carlos Barata, Benjamin Piña
Environmental Pollution, 2014
Chronic toxicity of the veterinary antibiotic florfenicol to Daphnia magna assessed at two temperatures
Alexandra Martins, Laura Guimarães, Lúcia Guilhermino
Environmental Toxicology and Pharmacology, 2013
Involvement of the antioxidant system in differential sensitivity of Carcinus maenas to fenitrothion exposure
A. P. Rodrigues, C. Gravato, L. Guimarães
Environmental Sciences Processes and Impacts, 2013
Toxic effects of pure anatoxin-a on biomarkers of rainbow trout, Oncorhynchus mykiss
Joana Osswald, António Paulo Carvalho, Laura Guimarães, Lúcia Guilhermino
Toxicon, 2013
Exposure of Carcinus maenas to waterborne fluoranthene: Accumulation and multibiomarker responses
A.P. Rodrigues, K.K. Lehtonen, L. Guilhermino, L. Guimarães
Science of the Total Environment, 2013
Effects of salinity stress on neurotransmission, energy metabolism, and anti-oxidant biomarkers of Carcinus maenas from two estuaries of the NW Iberian Peninsula
Aurélie Pinto Rodrigues, Patrícia Correia Oliveira, Lúcia Guilhermino, Laura Guimarães
Marine Biology, 2012
Exposure to industrial wideband noise increases connective tissue in the rat liver
Maria JoãoR Oliveira, Diamantino Freitas, AntónioP. O. Carvalho, Laura Guimarães, Ana Pinto, ArturP Águas
Noise and Health, 2012
Health status of Pomatoschistus microps populations in relation to pollution and natural stressors: Implications for ecological risk assessment
Laura Guimarães, Matias H. Medina, Lúcia Guilhermino
Biomarkers, 2012
Erratum: Acute and chronic toxicity of the pharmaceutical levonorgestrel to the freshwater crustacean Daphnia magna (Ecotoxicology)
A. L. Oropesa, L. Guimarães, A. Martins, F. Soler, L. Guilhermino
Ecotoxicology, 2012
Biochemical and locomotor responses of Carcinus maenas exposed to the serotonin reuptake inhibitor fluoxetine
Sofia Raquel Mesquita, Lúcia Guilhermino, Laura Guimarães
Chemosphere, 2011
Environmental issues in urban groundwater systems: A multidisciplinary study of the Paranhos and Salgueiros spring waters, Porto (NW Portugal)
Maria José Afonso, Helder I. Chaminé, José M. Marques, Paula M. Carreira, Laura Guimarães, Lúcia Guilhermino, Alberto Gomes, Paulo E. Fonseca, Ana Pires, Fernando Rocha
Environmental Earth Sciences, 2010
Comparative study about the effects of pollution on glass and yellow eels (Anguilla anguilla) from the estuaries of Minho, Lima and Douro Rivers (NW Portugal)
Carlos Gravato, Laura Guimarães, Joana Santos, Melissa Faria, Anabela Alves, Lúcia Guilhermino
Ecotoxicology and Environmental Safety, 2010
Yellow eel (Anguilla anguilla) development in NW portuguese estuaries with different contamination levels
Laura Guimarães, Carlos Gravato, Joana Santos, Luís S. Monteiro, Lúcia Guilhermino
Ecotoxicology, 2009
Exposure to retinoic acid at the onset of hindbrain segmentation induces episodic breathing in mice
Laura Guimarães, Eduardo Domínguez‐del‐Toro, Fabrice Chatonnet, Ludovic Wrobel, Cristina Pujades, Luís S. Monteiro, Jean Champagnat
European Journal of Neuroscience, 2007
The CAG repeat at the Huntington disease gene in the Portuguese population: Insights into its dynamics and to the origin of the mutation
Maria do Carmo Costa, Paula Magalhães, Laura Guimarães, Patrícia Maciel, Jorge Sequeiros, Alda Sousa
Journal of Human Genetics, 2006
Transient ischemic attacks in rural and urban northern Portugal: Incidence and short-term prognosis
Manuel Correia, Mário R. Silva, Rui Magalhães, Laura Guimarães, M. Carolina Silva
Stroke, 2006
Arrest in ciliated cell expansion on the bronchial lining of adult rats caused by chronic exposure to industrial noise
Maria João R. Oliveira, António S. Pereira, Paula G. Ferreira, Laura Guimarães, Diamantino Freitas, António P.O. Carvalho, Nuno R. Grande, Artur P. Águas
Environmental Research, 2005
Zonation of Ciliated Cells on the Epithelium of the Rat Trachea
M. J. R. Oliveira, A. S. Pereira, L. Guimar�es, N. R. Grande, C. Moreira de S�, A. P. �guas
Lung, 2003
Molecular diagnosis of Huntington disease in Portugal: Implications for genetic counselling and clinical practice
Maria do Carmo Costa, Paula Magalhães, Fátima Ferreirinha, Laura Guimarães, Cristina Januário, Isabel Gaspar, Leal Loureiro, José Vale, Carolina Garrett, Fernando Regateiro, Marina Magalhães, Alda Sousa, Patrícia Maciel, Jorge Sequeiros
European Journal of Human Genetics, 2003
Reduction of rat pleural microvilli caused by noise pollution
Maria Joāo R. Oliveira, António S. Pereira, Paula G. Ferreira, Nuno R. Grande, Artur P. A´guas, Laura Guimarāes, Diamantino Freitas, António P. O. Carvalho
Experimental Lung Research, 2003
Portuguese families with dentatorubropallidoluysian atrophy (DRPLA) share a common haplotype of Asian origin
Sandra Martins, Teresa Matamá, Laura Guimarães, José Vale, João Guimarães, Lina Ramos, Paula Coutinho, Jorge Sequeiros, Isabel Silveira
European Journal of Human Genetics, 2003
Chronic exposure of rats to cotton-mill-room noise changes the cell composition of the tracheal epithelium
Maria João R. Oliveira, António S. Pereira, Laura Guimarães, Diamantino Freitas, António P. O. Carvalho, Nuno R. Grande, Artur P. Águas
Journal of Occupational and Environmental Medicine, 2002
Trinucleotide repeats in 202 families with ataxia: A small expanded (CAG)n allele at the SCA17 locus
I. Silveira, C. Miranda, L. Guimarães, M.-C. Moreira, I. Alonso, P. Mendonça, A. Ferro, J. Pinto-Basto, J. Coelho, F. Ferreirinha, J. Poirier, E. Parreira, J. Vale, C. Januário, C. Barbot, A. Tuna, J. Barros, R. Koide, S. Tsuji, S. E. Holmes, R. L. Margolis, L. Jardim, M. Pandolfo, P. Coutinho, J. Sequeiros
Archives of Neurology, 2002
Genetic and developmental models for the neural control of breathing in vertebrates
Gilles Fortin, Eduardo Domı́nguez del Toro, Véronique Abadie, Laura Guimarães, Arthur S Foutz, Monique Denavit-Saubié, François Rouyer, Jean Champagnat
Respiration Physiology, 2000
High germinal instability of the (CTG)(n) at the SCA8 locus of both expanded and normal alleles
I. Silveira, I. Alonso, L. Guimarães, P. Mendonça, C. Santos, P. Maciel, J.M. Fidalgo de Matos, M. Costa, C. Barbot, A. Tuna, J. Barros, L. Jardim, P. Coutinho, J. Sequeiros
American Journal of Human Genetics, 2000
Study of three intragenic polymorphisms in the Machado-Joseph disease gene (MJD1) in relation to genetic instability of the (CAG)(n) tract
Patrícia Maciel, Claudia Gaspar, Laura Guimarães, Jun Goto, Iscia Lopes-Cendes, Sean Hayes, Karin Arvidsson, Aureliano Dias, Jorge Sequeiros, Alda Sousa, Guy A Rouleau
European Journal of Human Genetics, 1999

Laura Guimaraes

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