Dr Remya NS
@sctimst.ac.in
Scientist D, Department of Applied Biology
Sree Chitra Tirunal Institute for Medical Science and Technology
6
Scopus Publications
191
Scholar Citations
3
Scholar h-index
3
Scholar i10-index
Scopus Publications
- Animal component-free medium for long-term maintenance of human skin explants and its application in toxicity studies of cosmetics
N. S. Remya, Renjith P. Nair, and Anugya Bhatt
Springer Nature Singapore - Physico chemical characterisation of pectin incorporated gelatin sponge and its functional evaluation in modulating contact activation haemostasis
Remya NS, Lynda Thomas, Priyanka A, and Anugya Bhatt
SAGE Publications
Even though it is a common occurrence in practice, maintaining haemostasis can sometimes become a challenging issue in case of trauma, perioperative period, coagulation disorders, cancers, etc. Hemostatic materials are extensively used to assist in the cessation of bleeding. However, the definition of efficiency of haemostasis varies between intended procedures. This paper explores the feasibility of incorporating agents to increase the efficiency of local haemostasis. Pectin or β -D galacto hexopyranuronic acid/β Gal A, a structural polysaccharide widely present in terrestrial plants having an intrinsic hemostatic potential, is blended with gelatin and is explored in modulating passive haemostasis. The sponges are physico chemically characterized, and their hemostatic efficiency is evaluated in vitro using various assays. Biocompatibility evaluation is done by in vitro cytotoxicity assay. The results suggest that this biopolymer combination is a promising candidate for hemostatic control. - Certified Reference Material for Qualifying Biomaterials in Biological Evaluations
N. S. Remya and Leena Joseph
Springer Nature Singapore - Significance of Metrological Tools in an ISO 17025 Accredited Quality System for a Biological Evaluation Facility
Leena Joseph, P. Ramesh, N. S. Remya, V. Arumugham, and R. P. Rajesh
Springer Science and Business Media LLC - Natural Polymers: Applications, Biocompatibility, and Toxicity
- Regulatory issues in biological products
V.P. Sangeetha, N.S. Remya, and P.V. Mohanan
Elsevier - Toxicity studies of biomedical products
N.S. Remya, V.P. Sangeetha, and P.V. Mohanan
Elsevier - SARS-Cov-2 Detection by Quantitative PCR: A Technical Note on Concepts, Practical Considerations and Safety Aspects for Beginners
- Corrigendum to “An in vitro study on the interaction of hydroxyapatite nanoparticles and bone marrow mesenchymal stem cells for assessing the toxicological behaviour” [Colloids Surf. B: Biointerfaces 117 (2014) 389–397] (Colloids and Surfaces B: Biointerfaces (2014) 117 (389–397), (S0927776514000605), (10.1016/j.colsurfb.2014.02.004))
N.S. Remya, S. Syama, V. Gayathri, H.K. Varma, and P.V. Mohanan
Elsevier BV - Corrigendum to “Toxicity, toxicokinetics and biodistribution of dextran stabilized Iron oxide Nanoparticles for biomedical applications” [Int. J. Pharm. 511 (2016) 586–598] (International Journal of Pharmaceutics (2016) 511(1) (586–598), (S0378517316306093), (10.1016/j.ijpharm.2016.06.119))
N.S. Remya, S. Syama, A. Sabareeswaran, and P.V. Mohanan
Elsevier BV - Biocompatibility of strontium incorporated ceramic coated titanium oxide implant indented for orthopaedic applications
U. Vandana, D. Nancy, A. Sabareeswaran, N.S. Remya, N. Rajendran, and P.V. Mohanan
Elsevier BV - Matrix remodeling and mechanotransduction in in vitro chondrogenesis: Implications towards functional stem cell-based cartilage tissue engineering
Nirmal S. Remya and Prabha D. Nair
Wiley
Stem cell‐based cartilage regeneration strategies take benefits from functional tissue engineering concepts that effectively exploit cells native mechanotransduction phenomenon for the development of in vitro cartilage constructs. In the present study, stem cell‐seeded constructs were subjected to a dynamic compression of 10% strain, 1 Hz, 4 hours/1 hour each for 7 days. Integrin and Integrin‐associated protein expression was evaluated using real‐time PCR to elucidate the possible mechanotransduction pathway. Matrix remodeling was analyzed by evaluating chondrocyte‐specific extracellular matrix genes as well as by expression of matrix metalloproteinases. The results suggest that dynamic compression significantly influences chondrogenesis by enhancing the expression of chondrocyte‐specific extracellular matrix genes. The results also propose the involvement of Integrin‐mediated signaling pathways in the mechanotransduction events on biomechanical stimuli‐assisted chondrogenesis of stem cells. - Safety and toxicity concerns of nanosystems
N.S. Remya and P.V. Mohanan
Elsevier - Investigation of chronic toxicity of hydroxyapatite nanoparticles administered orally for one year in wistar rats
N.S. Remya, S. Syama, A. Sabareeswaran, and P.V. Mohanan
Elsevier BV - Engineered nanoparticles with antimicrobial property
Veliyath Gopi Reshma, Santhakumar Syama, Sudhakaran Sruthi, Sebastain Cherian Reshma, Nirmal Suma Remya, and Parayanthala Valappil Mohanan
Bentham Science Publishers Ltd.
BACKGROUND The urge for the development and manufacture of new and effective antimicrobial agents is particularly demanding especially in the present scenario of emerging multiple drug resistant microorganisms. A promising initiative would be to converge nanotechnology to develop novel strategies for antimicrobial treatment. These distinct nano scale properties confer impressive antimicrobial capabilities to nanomaterials that could be exploited. Nanotechnology particularly modulates the physicochemical properties of organic and inorganic nanoparticles, rendering them suitable for various applications related to antimicrobial therapy compared to their bulk counterparts. However, a major issue associated with such usage of nanomaterials is the safety concern on heath care system. Hence, a thorough put knowledge on biocompatible nanostructures intended for antimicrobial therapy is needed. METHODS A systematic review of the existing scientific literature is being attempted here which includes the properties and applications of a few nano structured materials for antimicrobial therapy and also the mechanism of action of nanomaterials as antimicrobial agents. Silver (Ag), Graphene, Quantum dots (QDs), Zinc oxide (ZnO) and chitosan nanoparticles are taken as representatives of metals, semiconductors, metal oxides and organic nanoparticles that have found several applications in antimicrobial therapy are reviewed in detail. RESULTS AND CONCLUSION An ideal anti microbial should selectively kill or inhibit the growth of microbes but cause little or no adverse effect to the host. Each of the engineered nanomaterials reviewed here has its own advantages and disadvantages. Nanomaterials in general directly disrupt the microbial cell membrane, interact with DNA and proteins or they could indirectly initiate the production of reactive oxygen species (ROS) that damage microbial cell components and viruses. Some like silver nanoparticles have broad spectrum antibacterial activity while others like cadmium containing QDs shows both antibacterial as well as antiprotozoal activity. Nano material formulations can be used directly or as surface coatings or as effective carriers for delivering antibiotics. Polycationic nature of Chitosan NPs helps in conjugation and stabilization of metallic nanoparticles which will enhance their effective usage in antimicrobial therapy. - Mechanoresponsiveness of human umbilical cord mesenchymal stem cells in in vitro chondrogenesis—A comparative study with growth factor induction
N. S. Remya and Prabha D. Nair
Wiley
Fetal-derived mesenchymal stem cells especially human umbilical cord matrix mesenchymal stem cells (hUCMSCs), with their ease of availability, pluripotency, and high expansion potential have emerged as an alternative solution for stem cell based cartilage therapies. An attempt to elucidate the effect of dynamic mechanical compression in modulating the chondrogenic differentiation of hUCMSCs is done in this study to add on to the knowledge of optimizing chondrogenic signals necessary for the effective differentiation of these stem cells and subsequent integration to the surrounding tissues. hUCMSCs were seeded in porous poly (vinyl alcohol)-poly (caprolactone) (PVA-PCL) scaffolds and cultured in chondrogenic medium with/without TGF-β3 and were subjected to a dynamic compression of 10% strain, 1 Hz for 1/4 h for 7 days. The results on various analysis shows that the extent of dynamic compression is an important factor affecting cell viability. Mechanical stimulation in the form of dynamic compression stimulates expression of chondrogenic genes even in the absence of chondrogenic growth factors and also augments growth factor induced chondrogenic potential of hUCMSC. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 104A: 2554-2566, 2016. - Toxicity, toxicokinetics and biodistribution of dextran stabilized Iron oxide Nanoparticles for biomedical applications
N.S. Remya, S. Syama, A. Sabareeswaran, and P.V. Mohanan
Elsevier BV - An in vitro study on the interaction of hydroxyapatite nanoparticles and bone marrow mesenchymal stem cells for assessing the toxicological behaviour
N.S. Remya, S. Syama, V. Gayathri, H.K. Varma, and P.V. Mohanan
Elsevier BV - Toxicological evaluation of imidazole following direct exposure to bone marrow mesenchymal stem cells
- Cells-nano interactions and molecular toxicity after delayed hypersensitivity, in Guinea pigs on exposure to hydroxyapatite nanoparticles
C.S. Geetha, N.S. Remya, K.B. Leji, S. Syama, S.C. Reshma, P.J. Sreekanth, H.K. Varma, and P.V. Mohanan
Elsevier BV - Engineering cartilage tissue interfaces using a natural glycosaminoglycan hydrogel matrix - An in vitro study
N.S. Remya and Prabha D. Nair
Elsevier BV - A biodegradable in situ injectable hydrogel based on chitosan and oxidized hyaluronic acid for tissue engineering applications
Sandhya Nair, N.S. Remya, S. Remya, and Prabha D. Nair
Elsevier BV
RECENT SCHOLAR PUBLICATIONS
- Unravelling the wound healing efficiency of 3D bioprinted alginate-gelatin-diethylaminoethyl cellulose-fibrinogen based skin construct in a ratfull thickness wound model
R Murali, RV Balasubramanian, VS Harikrishnan, N Kasoju, NS Remya, ...
International Journal of Biological Macromolecules, 140816 2025 - Animal Component-Free Medium for Long-Term Maintenance of Human Skin Explants and Its Application in Toxicity Studies of Cosmetics
NS Remya, RP Nair, A Bhatt
Skin 3-D Models and Cosmetics Toxicity, 137-148 2023 - Physico chemical characterisation of pectin incorporated gelatin sponge and its functional evaluation in modulating contact activation haemostasis
R Ns, L Thomas, A Bhatt
Journal of Biomaterials Applications 38 (2), 215-231 2023 - Exploring Nature’s Canvas: Witnessing the Artistry of Biodegradation
NS Remya
OPINIONS IN Medical Sciences, Technology and Health 1 (2), e23015-e23015 2023 - Digital health: trends, opportunities and challenges in medical devices, pharma and bio-technology
N Kasoju, NS Remya, R Sasi, S Sujesh, B Soman, C Kesavadas, ...
CSI Transactions on ICT 11 (1), 11-30 2023 - Correction: Engineered nanostructures within sol–gel bioactive glass for enhanced bioactivity and modulated drug delivery
LM Mukundan, N Kumar, S Dhara, S Chattopadhyay
Journal of Materials Chemistry B 11 (3), 688-688 2023 - Significance of metrological tools in an ISO 17025 accredited quality system for a biological evaluation facility
L Joseph, P Ramesh, NS Remya, V Arumugham, RP Rajesh
Mapan 37 (3), 683-691 2022 - Growth and Regeneration of Osteochondral Cells in Bioactive Niche: A Promising Approach for Osteochondral Tissue Repair
LM Mukundan, RS Nirmal, PD Nair
ACS Applied Bio Materials 5 (6), 2676-2688 2022 - Natural Polymers: Applications, Biocompatibility, and Toxicity
NS Remya
Natural Polymers Perspectives and Applications for a Green Approach 2022 - Engineered nanostructures within sol–gel bioactive glass for enhanced bioactivity and modulated drug delivery
LM Mukundan, N Kumar, S Dhara, S Chattopadhyay
Journal of Materials Chemistry B 10 (48), 10112-10127 2022 - Certified Reference Material for Qualifying Biomaterials in Biological Evaluations.
JL Remya, N.S.
Handbook of Metrology and Applications., pp 1–18 2022 - SARS-Cov-2 Detection by Quantitative PCR: A Technical Note on Concepts, Practical Considerations and Safety Aspects for Beginners
MN N.S. Remya, Naresh Kasoju
Trends Biomater. Artif. Organs 36 (1), 68-76 2022 - Regulatory issues in biological products
VP Sangeetha, NS Remya, PV Mohanan
Biomedical Product and Materials Evaluation, 309-327 2022 - Toxicity studies of biomedical products
NS Remya, VP Sangeetha, PV Mohanan
Biomedical Product and Materials Evaluation, 483-500 2022 - Biocompatibility of strontium incorporated ceramic coated titanium oxide implant indented for orthopaedic applications
U Vandana, D Nancy, A Sabareeswaran, NS Remya, N Rajendran, ...
Materials Science and Engineering: B 264, 114954 2021 - Preparation and standardization of a batch of Reference Biomaterials (RM) for biological evaluations (Project-8169)
J Leena, P Ramesh, NS Remya, V Ramesh Babu, PR Anil Kumar, ...
SCTIMST 2020 - Matrix remodeling and mechanotransduction in in vitro chondrogenesis: Implications towards functional stem cell-based cartilage tissue engineering
NSRPD Nair
Engineering reports 12145 2020 - Safety and toxicity concerns of nanosystems
NS Remya, PV Mohanan
Drug Delivery Nanosystems for Biomedical Applications, 33-44 2018 - Engineered nanoparticles with antimicrobial property
VG Reshma, S Syama, S Sruthi, SC Reshma, NS Remya, PV Mohanan
Current Drug Metabolism 18 (11), 1040-1054 2017 - Investigation of chronic toxicity of hydroxyapatite nanoparticles administered orally for one year in wistar rats
NS Remya, S Syama, A Sabareeswaran, PV Mohanan
Materials Science and Engineering: C 76, 518-527 2017
MOST CITED SCHOLAR PUBLICATIONS
- Toxicity, toxicokinetics and biodistribution of dextran stabilized Iron oxide Nanoparticles for biomedical applications
NS Remya, S Syama, A Sabareeswaran, PV Mohanan
International journal of pharmaceutics 511 (1), 586-598 2016
Citations: 105 - An in vitro study on the interaction of hydroxyapatite nanoparticles and bone marrow mesenchymal stem cells for assessing the toxicological behaviour
NS Remya, S Syama, V Gayathri, HK Varma, PV Mohanan
Colloids and Surfaces B: Biointerfaces 117, 389-397 2014
Citations: 100 - Digital health: trends, opportunities and challenges in medical devices, pharma and bio-technology
N Kasoju, NS Remya, R Sasi, S Sujesh, B Soman, C Kesavadas, ...
CSI Transactions on ICT 11 (1), 11-30 2023
Citations: 90 - A biodegradable in situ injectable hydrogel based on chitosan and oxidized hyaluronic acid for tissue engineering applications
S Nair, NS Remya, S Remya, PD Nair
Carbohydrate polymers 85 (4), 838-844 2011
Citations: 90 - Engineered nanoparticles with antimicrobial property
VG Reshma, S Syama, S Sruthi, SC Reshma, NS Remya, PV Mohanan
Current Drug Metabolism 18 (11), 1040-1054 2017
Citations: 58 - Significance of soluble growth factors in the chondrogenic response of human umbilical cord matrix stem cells in a porous three dimensional scaffold
RS Nirmal, PD Nair
Eur Cell Mater 26 (11), 234-51 2013
Citations: 50 - A new synthesis route to high surface area sol gel bioactive glass through alcohol washing: a preliminary study
LM Mukundan, R Nirmal, D Vaikkath, PD Nair
Biomatter 3 (2), e24288 2013
Citations: 49 - Engineering cartilage tissue interfaces using a natural glycosaminoglycan hydrogel matrix—an in vitro study
NS Remya, PD Nair
Materials Science and Engineering: C 33 (2), 575-582 2013
Citations: 43 - Investigation of chronic toxicity of hydroxyapatite nanoparticles administered orally for one year in wistar rats
NS Remya, S Syama, A Sabareeswaran, PV Mohanan
Materials Science and Engineering: C 76, 518-527 2017
Citations: 38 - Cells–nano interactions and molecular toxicity after delayed hypersensitivity, in Guinea pigs on exposure to hydroxyapatite nanoparticles
CS Geetha, NS Remya, KB Leji, S Syama, SC Reshma, PJ Sreekanth, ...
Colloids and Surfaces B: Biointerfaces 112, 204-212 2013
Citations: 25 - Mechanoresponsiveness of human umbilical cord mesenchymal stem cells in in vitro chondrogenesis—A comparative study with growth factor induction
NS Remya, PD Nair
Journal of Biomedical Materials Research Part A 104 (10), 2554-2566 2016
Citations: 20 - Biocompatibility of strontium incorporated ceramic coated titanium oxide implant indented for orthopaedic applications
U Vandana, D Nancy, A Sabareeswaran, NS Remya, N Rajendran, ...
Materials Science and Engineering: B 264, 114954 2021
Citations: 16 - Stem cells, a new generation model for predictive nano toxicological assessment
R Nirmal Suma, P Valappil Mohanan
Current Drug Metabolism 16 (10), 932-939 2015
Citations: 14 - Significance of metrological tools in an ISO 17025 accredited quality system for a biological evaluation facility
L Joseph, P Ramesh, NS Remya, V Arumugham, RP Rajesh
Mapan 37 (3), 683-691 2022
Citations: 8 - Retrieval of rat aortic smooth muscle cells as intact cell sheet for regenerative medicine: a cost effective approach using photo polymerization
LM Mukundan, R Nirmal, LV Thomas, US Sajeev, PD Nair
Biotechnology letters 33, 2083-2089 2011
Citations: 6 - Engineered nanostructures within sol–gel bioactive glass for enhanced bioactivity and modulated drug delivery
LM Mukundan, N Kumar, S Dhara, S Chattopadhyay
Journal of Materials Chemistry B 10 (48), 10112-10127 2022
Citations: 4 - A PVA-PCL bioglass composite with potential implications for osteochondral tissue engineering
PD Nair, LM Mukundan, R Nirmal, N Mohan
MRS Online Proceedings Library (OPL) 1235, 1235-RR03-28 2009
Citations: 4 - Growth and Regeneration of Osteochondral Cells in Bioactive Niche: A Promising Approach for Osteochondral Tissue Repair
LM Mukundan, RS Nirmal, PD Nair
ACS Applied Bio Materials 5 (6), 2676-2688 2022
Citations: 3 - Regulatory issues in biological products
VP Sangeetha, NS Remya, PV Mohanan
Biomedical Product and Materials Evaluation, 309-327 2022
Citations: 3 - Safety and toxicity concerns of nanosystems
NS Remya, PV Mohanan
Drug Delivery Nanosystems for Biomedical Applications, 33-44 2018
Citations: 3