Dr Remya NS
@sctimst.ac.in
Scientist D, Department of Applied Biology
Sree Chitra Tirunal Institute for Medical Science and Technology
Scopus Publications
Scholar Citations
Scholar h-index
Scholar i10-index
Scopus Publications
Lakshmi M. Mukundan, Remya Nirmal S., Nikhil Kumar, Santanu Dhara, and Santanu Chattopadhyay
Royal Society of Chemistry (RSC)
Correction for ‘Engineered nanostructures within sol–gel bioactive glass for enhanced bioactivity and modulated drug delivery’ by Lakshmi M. Mukundan et al., J. Mater. Chem. B, 2022, https://doi.org/10.1039/d2tb01692c.
Leena Joseph, P. Ramesh, N. S. Remya, V. Arumugham, and R. P. Rajesh
Springer Science and Business Media LLC
V.P. Sangeetha, N.S. Remya, and P.V. Mohanan
Elsevier
N.S. Remya, V.P. Sangeetha, and P.V. Mohanan
Elsevier
N.S. Remya, S. Syama, V. Gayathri, H.K. Varma, and P.V. Mohanan
Elsevier BV
N.S. Remya, S. Syama, A. Sabareeswaran, and P.V. Mohanan
Elsevier BV
U. Vandana, D. Nancy, A. Sabareeswaran, N.S. Remya, N. Rajendran, and P.V. Mohanan
Elsevier BV
Nirmal S. Remya and Prabha D. Nair
Wiley
Stem cell‐based cartilage regeneration strategies take benefits from functional tissue engineering concepts that effectively exploit cells native mechanotransduction phenomenon for the development of in vitro cartilage constructs. In the present study, stem cell‐seeded constructs were subjected to a dynamic compression of 10% strain, 1 Hz, 4 hours/1 hour each for 7 days. Integrin and Integrin‐associated protein expression was evaluated using real‐time PCR to elucidate the possible mechanotransduction pathway. Matrix remodeling was analyzed by evaluating chondrocyte‐specific extracellular matrix genes as well as by expression of matrix metalloproteinases. The results suggest that dynamic compression significantly influences chondrogenesis by enhancing the expression of chondrocyte‐specific extracellular matrix genes. The results also propose the involvement of Integrin‐mediated signaling pathways in the mechanotransduction events on biomechanical stimuli‐assisted chondrogenesis of stem cells.
N.S. Remya and P.V. Mohanan
Elsevier
N.S. Remya, S. Syama, A. Sabareeswaran, and P.V. Mohanan
Elsevier BV
Veliyath Gopi Reshma, Santhakumar Syama, Sudhakaran Sruthi, Sebastain Cherian Reshma, Nirmal Suma Remya, and Parayanthala Valappil Mohanan
Bentham Science Publishers Ltd.
BACKGROUND
The urge for the development and manufacture of new and effective antimicrobial agents is particularly demanding especially in the present scenario of emerging multiple drug resistant microorganisms. A promising initiative would be to converge nanotechnology to develop novel strategies for antimicrobial treatment. These distinct nano scale properties confer impressive antimicrobial capabilities to nanomaterials that could be exploited. Nanotechnology particularly modulates the physicochemical properties of organic and inorganic nanoparticles, rendering them suitable for various applications related to antimicrobial therapy compared to their bulk counterparts. However, a major issue associated with such usage of nanomaterials is the safety concern on heath care system. Hence, a thorough put knowledge on biocompatible nanostructures intended for antimicrobial therapy is needed.
METHODS
A systematic review of the existing scientific literature is being attempted here which includes the properties and applications of a few nano structured materials for antimicrobial therapy and also the mechanism of action of nanomaterials as antimicrobial agents. Silver (Ag), Graphene, Quantum dots (QDs), Zinc oxide (ZnO) and chitosan nanoparticles are taken as representatives of metals, semiconductors, metal oxides and organic nanoparticles that have found several applications in antimicrobial therapy are reviewed in detail.
RESULTS AND CONCLUSION
An ideal anti microbial should selectively kill or inhibit the growth of microbes but cause little or no adverse effect to the host. Each of the engineered nanomaterials reviewed here has its own advantages and disadvantages. Nanomaterials in general directly disrupt the microbial cell membrane, interact with DNA and proteins or they could indirectly initiate the production of reactive oxygen species (ROS) that damage microbial cell components and viruses. Some like silver nanoparticles have broad spectrum antibacterial activity while others like cadmium containing QDs shows both antibacterial as well as antiprotozoal activity. Nano material formulations can be used directly or as surface coatings or as effective carriers for delivering antibiotics. Polycationic nature of Chitosan NPs helps in conjugation and stabilization of metallic nanoparticles which will enhance their effective usage in antimicrobial therapy.
N. S. Remya and Prabha D. Nair
Wiley
Fetal-derived mesenchymal stem cells especially human umbilical cord matrix mesenchymal stem cells (hUCMSCs), with their ease of availability, pluripotency, and high expansion potential have emerged as an alternative solution for stem cell based cartilage therapies. An attempt to elucidate the effect of dynamic mechanical compression in modulating the chondrogenic differentiation of hUCMSCs is done in this study to add on to the knowledge of optimizing chondrogenic signals necessary for the effective differentiation of these stem cells and subsequent integration to the surrounding tissues. hUCMSCs were seeded in porous poly (vinyl alcohol)-poly (caprolactone) (PVA-PCL) scaffolds and cultured in chondrogenic medium with/without TGF-β3 and were subjected to a dynamic compression of 10% strain, 1 Hz for 1/4 h for 7 days. The results on various analysis shows that the extent of dynamic compression is an important factor affecting cell viability. Mechanical stimulation in the form of dynamic compression stimulates expression of chondrogenic genes even in the absence of chondrogenic growth factors and also augments growth factor induced chondrogenic potential of hUCMSC. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 104A: 2554-2566, 2016.
N.S. Remya, S. Syama, A. Sabareeswaran, and P.V. Mohanan
Elsevier BV
N.S. Remya, S. Syama, V. Gayathri, H.K. Varma, and P.V. Mohanan
Elsevier BV
C.S. Geetha, N.S. Remya, K.B. Leji, S. Syama, S.C. Reshma, P.J. Sreekanth, H.K. Varma, and P.V. Mohanan
Elsevier BV
N.S. Remya and Prabha D. Nair
Elsevier BV
Sandhya Nair, N.S. Remya, S. Remya, and Prabha D. Nair
Elsevier BV