Scott Mazurkewich

@chalmers.se

Division of Industrial Biotechnology at the Department of Life Sciences
Chalmers University of Technology

EDUCATION

Doctor of Philosophy in Biochemistry
University of Guelph, Ontario, Canada, 2010 – 2016
• Advisor: Dr. Stephen Y. K. Seah
• Structure-function characterizations of enzymes from the lignin degradative pathways of Pseudomonas putida, important pathways that could be harnessed for biomass utilization.

Honours Baccalaureate of Science in Biochemistry
University of Guelph, Ontario, Canada, 2005 – 2010

402

Scholar Citations

Scholar h-index

Scholar i10-index

RECENT SCHOLAR PUBLICATIONS

Exploration of three Dyadobacter fermentans enzymes uncovers molecular activity determinants in CE15
M Carbonaro, S Mazurkewich, G Fiorentino, L Lo Leggio, J Larsbrink
Applied Microbiology and Biotechnology 108 (1), 1-11 2024

Boosting Enzyme Activity in Biomass Conversion by Modulating the Hydrolysis Process of Cellobiohydrolases
H Liu, Y Ding, S Mazurkewich, W Pei, X Wei, J Larsbrink, C Chipot, ...
ACS Catalysis 14 (21), 16044-16054 2024

Genomic mining of Geobacillus stearothermophilus GF16 for xylose production from hemicellulose-rich biomasses using secreted enzymes
M Carbonaro, M Aulitto, S Mazurkewich, A Di Fraia, P Contursi, D Limauro, ...
New Biotechnology 82, 14-24 2024

Streptomyces castrisilvae sp. nov. and Streptomyces glycanivorans sp. nov., novel soil streptomycetes metabolizing mutan and alternan
T Widn, AT Rangel, V Lombard, E Drula, S Mazurkewich, N Terrapon, ...
International Journal of Systematic and Evolutionary Microbiology 74 (9), 006514 2024

Structural and biochemical analysis of family 92 carbohydrate-binding modules uncovers multivalent binding to β-glucans
MS Hao, S Mazurkewich, H Li, A Kvammen, S Saha, S Koskela, AR Inman, ...
Nature Communications 15 (1), 3429 2024

Polysaccharide utilization loci from Bacteroidota encode CE15 enzymes with possible roles in cleaving pectin-lignin bonds
A Seveso, S Mazurkewich, S Banerjee, JCN Poulsen, L Lo Leggio, ...
Applied and Environmental Microbiology 90 (1), e01768-23 2024

A unique AA5 alcohol oxidase fused with a catalytically inactive CE3 domain from the bacterium Burkholderia pseudomallei
S Mazurkewich, A Seveso, J Larsbrink
FEBS letters 597 (13), 1779-1791 2023

Structural and functional investigation of a fungal member of carbohydrate esterase family 15 with potential specificity for rare xylans
S Mazurkewich, KC Scholzen, RH Brusch, JCN Poulsen, Y Theibich, ...
Acta Crystallographica Section D: Structural Biology 79 (6) 2023

Structural diversity and substrate preferences of three tannase enzymes encoded by the anaerobic bacterium Clostridium butyricum
AS Ristinmaa, T Coleman, L Cesar, AL Weinmann, S Mazurkewich, ...
Journal of Biological Chemistry 298 (4) 2022

Mechanism and biomass association of glucuronoyl esterase: an α/β hydrolase with potential in biomass conversion
Z Zong, S Mazurkewich, CS Pereira, H Fu, W Cai, X Shao, MS Skaf, ...
Nature Communications 13 (1), 1449 2022

Mechanism and biomass association of glucuronoyl esterase: an α/β hydrolase with potential in biomass conversion. Nat Commun 13: 1–10
Z Zong, S Mazurkewich, CS Pereira, H Fu, W Cai, X Shao, MS Skaf, ...
2022

Characterization of a novel multidomain CE15-GH8 enzyme encoded by a polysaccharide utilization locus in the human gut bacterium Bacteroides eggerthii
C Kmezik, D Krska, S Mazurkewich, J Larsbrink
Scientific Reports 11 (1), 17662 2021

Structure of a C1/C4-oxidizing AA9 lytic polysaccharide monooxygenase from the thermophilic fungus Malbranchea cinnamomea
S Mazurkewich, A Seveso, S Httner, G Brndn, J Larsbrink
Acta Crystallographica Section D: Structural Biology 77 (8), 1019-1026 2021

Structural and Functional Analysis of a Multimodular Hyperthermostable Xylanase-Glucuronoyl Esterase from Caldicellulosiruptor kristjansonii
D Krska, S Mazurkewich, HA Brown, Y Theibich, JCN Poulsen, AL Morris, ...
Biochemistry 60 (27), 2206-2220 2021

A polysaccharide utilization locus from the gut bacterium Dysgonomonas mossii encodes functionally distinct carbohydrate esterases
C Kmezik, S Mazurkewich, T Meents, LS McKee, A Idstrm, M Armeni, ...
Journal of Biological Chemistry 296 2021

Multimodular fused acetyl–feruloyl esterases from soil and gut Bacteroidetes improve xylanase depolymerization of recalcitrant biomass
C Kmezik, C Bonzom, L Olsson, S Mazurkewich, J Larsbrink
Biotechnology for biofuels 13, 1-14 2020

Genomic and transcriptomic analysis of Candida intermedia reveals the genetic determinants for its xylose-converting capacity
C Geijer, F Faria-Oliveira, AD Moreno, S Stenberg, S Mazurkewich, ...
Biotechnology for biofuels 13, 1-15 2020

Structural insights of the enzymes from the chitin utilization locus of Flavobacterium johnsoniae
S Mazurkewich, R Helland, A Mackenzie, VGH Eijsink, PB Pope, ...
Scientific Reports 10 (1), 13775 2020

Structural and biochemical studies of the glucuronoyl esterase OtCE15A illuminate its interaction with lignocellulosic components
S Mazurkewich, JCN Poulsen, LL Leggio, J Larsbrink
Journal of Biological Chemistry 294 (52), 19978-19987 2019

Active site evolution in biomass degrading enzymes
KEH Frandsen, T Tandrup, JCN Poulsen, S Mazurkewich, Q Huang, ...
Acta Crystallographica Section A: Foundations and Advances 75, e124-e124 2019

MOST CITED SCHOLAR PUBLICATIONS

Biochemical and structural features of diverse bacterial glucuronoyl esterases facilitating recalcitrant biomass conversion
J Arnling Bth, S Mazurkewich, RM Knudsen, JCN Poulsen, L Olsson, ...
Biotechnology for biofuels 11, 1-14 2018
Citations: 49

Structural and kinetic characterization of 4-hydroxy-4-methyl-2-oxoglutarate/4-carboxy-4-hydroxy-2-oxoadipate aldolase, a protocatechuate degradation enzyme evolutionarily
W Wang, S Mazurkewich, MS Kimber, SYK Seah
Journal of Biological Chemistry 285 (47), 36608-36615 2010
Citations: 40

Structure–function analyses reveal that a glucuronoyl esterase from Teredinibacter turnerae interacts with carbohydrates and aromatic compounds
JA Bth, S Mazurkewich, JCN Poulsen, L Olsson, LL Leggio, J Larsbrink
Journal of Biological Chemistry 294 (16), 6635-6644 2019
Citations: 28

Structural and kinetic characterization of the 4-carboxy-2-hydroxymuconate hydratase from the gallate and protocatechuate 4, 5-cleavage pathways of Pseudomonas putida KT2440
S Mazurkewich, AS Brott, MS Kimber, SYK Seah
Journal of Biological Chemistry 291 (14), 7669-7686 2016
Citations: 22

Biochemical and structural analysis of RraA proteins to decipher their relationships with 4-hydroxy-4-methyl-2-oxoglutarate/4-carboxy-4-hydroxy-2-oxoadipate aldolases
S Mazurkewich, W Wang, SYK Seah
Biochemistry 53 (3), 542-553 2014
Citations: 8

Investigation into the Mode of Phosphate Activation in the 4-Hydroxy-4-Methyl-2-Oxoglutarate/4-Carboxy-4-Hydroxy-2-Oxoadipate Aldolase from Pseudomonas putida F1
S Mazurkewich, SYK Seah
Plos one 11 (10), e0164556 2016
Citations: 4