A promising biomarker to distinguish benign and malignant renal tumors: Elabela G. Artaş, T. Kuloğlu, A. Dağlı, K. Ugur, M. Yardim, et al. Nigerian Journal of Clinical Practice, 2019 Aim: The aim of this study was to investigate ELABELA (ELA) expression in benign and malignant renal tissues and expression differences in different nuclear grades of clear cell carcinomas. Materials and Methods: Patients that underwent surgery due to renal masses between the years of 2007 and 2017 were used. Control renal tissues (n = 23), papillary RCC (n = 23), clear cell RCC (CcRCC) [Fuhrman Grade1 (n = 23), Fuhrman Grade2 (n = 23), Fuhrman Grade3 (n = 23), Fuhrman Grade4 (n = 23)], and chromophobe RCC (n = 23) were included to the study. The Independent samples t-test was used for 2-point intergroup assessments and the one-way analysis of variance and posthoctukey test was used for the others. Values of P < 0.05 were considered statistically significant. Results: ELA immunoreactivity was observed in proximal and distal tubules in the kidney, but not in glomeruli in control tissues. When compared with control kidney tissue, a statistically significant increase was observed in ELA immunoreactivity in renal oncocytoma. In the chromophobe RCC, ELA immunoreactivity was significantly lower than control kidney tissue, whereas papillary RCC did not show ELA immunoreactivity. However, compared with control kidney tissue, ELA immunoreactivity was not observed in Fuhrman Grade 1 and Grade 2 CcRCC. Also, there was a significant decrease at Fuhrman Grade 3 and Grade 4 CcRCC compared with control kidney tissues. In the statistical analysis of ELA immunoreactivity among the Fuhrman nuclear grades of CcRCCs, The ELA immunoreactivity was higher at Grade 4 CcRCC than Grade 1, Grade 2, and Grade 3. Conclusion: ELA is a usefull molecule to differentiate benign and malign renal tumors. But further broad and comprehensive studies are needed to investigate cellular and molecular mechanisms of ELAs on malign transformation.
Inhibition of cancer stem-like phenotype by curcumin and deguelin in CAL-62 anaplastic thyroid cancer cells Mehmet A. Kocdor, Hakan Cengiz, Halil Ates, Hilal Kocdor Anti Cancer Agents in Medicinal Chemistry, 2019 Background:Anaplastic Thyroid Cancer (ATC) is one of the most lethal and aggressive human malignancies. Studies have shown that Cancer Stem-Cell (CSC) phenotype is mainly responsible for ATC aggressiveness. Cytostatic compounds are mostly ineffective because of multidrug resistance mechanisms driven by the CSC phenotype. Taxanes have limited efficacy. Recently, CSC inhibition using plant-derived, less toxic compounds, which have anti-cancer efficacy, has become a novel treatment modality. The aim of the study was to evaluate the anti-cancer activity of two natural compounds (curcumin and deguelin) on ATC cells and their CSC properties. In addition, the efficacies of these compounds were compared with that of docetaxel.Methods:Besides control, five treatment groups were formed. ATC cells (CAL-62) were treated with curcumin, deguelin, docetaxel, and their combinations (curcumin+docetaxel, deguelin+docetaxel) at previously determined IC50 doses. Stemness was analyzed by quantitative estimation of sphere formation in matrigel, expression of several cell surface markers (CD133, CD90, Nanog, and OCT3/4) using flow cytometry, and quantification of the hypoxic status [Oxidative Stress Index (OSI) and Superoxide Dismutase (SOD) activity]. The anti-cancer efficacies of these compounds and their combinations were evaluated by determining the alterations in the cell cycle, apoptosis, and tumoral cell migration.Results:Both the natural compounds (particularly curcumin) significantly suppressed the spheroid formation and cellular motility in matrigel as well as suppressed the accumulation of cells in the G0/1 phase, in which the maximum CSC activity is observed. The compounds did not suppress the expression of CSC markers, but twothirds of the cells expressed CD90. Deguelin was found to be particularly effective in inducing apoptosis similar to docetaxel at IC50 concentrations. Curcumin reduced the OSI and deguelin enhanced the SOD activity, even in docetaxel pre-treated cells.Conclusion:A large proportion of anaplastic tumors might consist of heterogeneous CSC population. Curcumin and deguelin have anti-cancer and several anti-stem cell activities against ATC cells. These natural compounds are capable of altering the aggressive behavior of ATC cells through the inhibition of the CSC phenotype. As a novel therapeutic target, CD90 should be investigated in other ATC cell lines and in vivo models.
Evaluation of the first Turkish in vitro diagnostic symposium Fadime Aydin Kose, Serap Celebi, Hakan Cengiz, Duygu Harmanci, Ayse Kocak, et al. Turkish Journal of Biochemistry, 2017 In vitro diagnostic (IVD) medical laboratory devices, tests and equipment are closely related with public health, patient safety and the safety of all who utilize these tools in laboratories. The close monitoring of the process from the production line to the end-point user is crucial so that IVD devices and tests do not pose a risk to individuals and society. Based on this background, the “First Turkish in vitro Diagnostic Symposium: Medical Laboratory Tests” was held in February, 2016. The symposium was organized by the cooperation of Turkish Biochemical Society, Izmir Branch and Dokuz Eylul University Health Sciences Institute along with the contributions of TurkLab Calibration Association. It was intended that the meeting would shed light on questions such as, ‘What is the place and importance of IVD in Turkey?’, ‘What are the responsibilities of educational institutions?’, ‘What is the role of Ministry of Health?’, with the aim that the answers would help to determine the infrastructure needed for successful production of IVD medical devices in Turkey. At the end of the symposium, feedback from participants were collected via a questionnaire. This article presents the general evaluation of the symposium based on the results of this survey.
The report of the 1st Turkey in vitro diagnostic symposium results Hilal Kocdor, Ebru Sezer, Zubeyde Erbayraktar, Aysun Pabuccuoglu, Taner Onat, et al. Turkish Journal of Biochemistry, 2017 “The 1st Turkish in vitro Diagnostic Symposium” was organized in İzmir between the dates 18–20 February 2016 with cooperation of Turkish Biochemistry Society Izmir Branch and Dokuz Eylul University Institute of Health Sciences. This article presents a collection of the subjects, recommendations and results included in the final report of the symposium. Symposium subjects were analysed under separate titles and evaluated together with results obtained from various reports on medical devices (MD) in the last decade. According to the final report, the subjects to be considered on preferential basis include “configuration of the websites of legal authorities, standardization and accreditation institutions in a way to access work on in vitro Diagnostic (IVD)”, “activation of university-industry cooperation”, “determination of national standards parallel to international standards” and “carrying out the statistics about IVD-MD in Turkey as immediate as possible”. Drawing attention to the fact that there is a requirement for competent man power for every-stage of IVD-MD lifecycle, it is recommended that postgraduate education programmes are founded to serve these fields. Consequently, this symposium enabled to determine the basic problems about the sector by bringing together the stakeholders related to IVD-MD field and to come up with an action plan in accordance with the recommendations.
Irisin immunohistochemistry in gastrointestinal system cancers S Aydin, T Kuloglu, MR Ozercan, S Albayrak, S Aydin, et al. Biotechnic and Histochemistry, 2016 Cancer is the leading cause of morbidity and mortality worldwide. Some studies have shown that high heat kills cancer cells. Irisin is a protein involved in heat production by converting white into brown adipose tissue, but there is no information about how its expression changes in cancerous tissues. We used irisin antibody immunohistochemistry to investigate changes in irisin expression in gastrointestinal cancers compared to normal tissues. Irisin was found in human brain neuroglial cells, esophageal epithelial cells, esophageal epidermoid carcinoma, esophageal adenocarcinoma and neuroendocrine esophageal carcinoma, gastric glands, gastric adenosquamous carcinoma, gastric neuroendocrine carcinoma, gastric signet ring cell carcinoma, neutrophils in vascular tissues, intestinal glands of colon, colon adenocarcinoma, mucinous colon adenocarcinoma, hepatocytes, hepatocellular carcinoma, islets of Langerhans, exocrine pancreas, acinar cells and interlobular and interlobular ducts of normal pancreas, pancreatic ductal adenocarcinoma, and intra- and interlobular ducts of cancerous pancreatic tissue. Histoscores (area × intensity) indicated that irisin was increased significantly in gastrointestinal cancer tissues, except liver cancers. Our findings suggest that the relation of irisin to cancer warrants further investigation.
Zinc supplementation induces apoptosis and enhances antitumor efficacy of docetaxel in non-small-cell lung cancer Hilal Kocdor, Halil Ates, Suleyman Aydin, Ruksan Cehreli, Firat Soyarat, et al. Drug Design Development and Therapy, 2015 Background Exposure to exogenous zinc results in increased apoptosis, growth inhibition, and altered oxidative stress in cancer cells. Previous studies also suggested that zinc sensitizes some cancer cells to cytotoxic agents depending on the p53 status. Therefore, zinc supplementation may show anticancer efficacy solely and may increase docetaxel-induced cytotoxicity in non-small-cell lung cancer cells. Methods Here, we report the effects of several concentrations of zinc combined with docetaxel on p53-wild-type (A549) and p53-null (H1299) cells. We evaluated cellular viability, apoptosis, and cell cycle progression as well as oxidative stress parameters, including superoxide dismutase, glutathione peroxidase, and malondialdehyde levels. Results Zinc reduced the viability of A549 cells and increased the apoptotic response in both cell lines in a dose-dependent manner. Zinc also amplified the docetaxel effects and reduced its inhibitory concentration 50 (IC50) values. The superoxide dismutase levels increased in all treatment groups; however, glutathione peroxidase was slightly increased in the combination treatments. Zinc also caused malondialdehyde elevations at 50 μM and 100 μM. Conclusion Zinc has anticancer efficacy against non-small-cell lung cancer cells in the presence of functionally active p53 and enhances docetaxel efficacy in both p53-wild-type and p53-deficient cancer cells.
Ghrelin expression of endometrium hyperplasia and endometrioid carcinoma Adile F. Dagli, Suleyman Aydin, Hilal Kocdor, Bilgin Gurates, İbrahim Sahin, et al. Gynecological Endocrinology, 2011 Background. Endometrium carcinoma ranks fourth among female carcinomas. Therefore, early diagnosis of endometrium pre-malignant lesions is emphasised, and attempts are made to identify the risk factors. Since hyperplasias, particularly those with atypia, are held responsible for the development of the most common endometrium carcinomas, it is important to definitely distinguish between well-differentiated carcinomas and hyperplasia with atypia. In the present study, we aimed to explore whether ghrelin expression had a role in distinguishing between benign, pre-malignant and malignant lesions of endometrium. Methods. Tissue ghrelin expressions of a total of 60 cases, who were diagnosed in the Pathology Department Laboratory of Fırat University Medical School, and of whom 10 were in the proliferation phase, 10 had simple hyperplasia without atypia, 10 had simple hyperplasia with atypia, 10 had complex hyperplasia without atypia, 10 had complex hyperplasia with atypia and 10 had endometrioid carcinoma cases, were examined using immunohistochemical method. Additionally, tissue samples were homogenised to analyse tissue ghrelin levels in the supernatants according to RIA method. Samples from the parotid glands were used as positive control for ghrelin. Cells that exhibited cytoplasmic staining with ghrelin antibody were evaluated as positive. Results. Immunohistochemical examination showed that ghrelin expression increased markedly in the proliferation phase, relative to hyperplasias and carcinoma. These results were parallel to ghrelin levels in tissue supernatants. Immunohistochemical and RIA analysis results indicate that ghrelin expression either markedly decreases or is entirely depleted in endometrial carcinomas. Conclusions. Therefore, we think that ghrelin expression can be useful in differentiating not only endometrium carcinomas from benign lesions but also complex hyperplasias with atypia, which pose diagnostic difficulties.
The effects of parenteral glutamine on intestinal adaptation in a rat model of short bowel syndrome Ahmet Ucar, Hilal Kocdor, Aras Canda, Sadiye Unlu, Ruksan Cehreli, et al. Central European Journal of Medicine, 2010 Short bowel syndrome (SBS) is characterized by the malabsorption of nutrients and fluids that occurs after major intestinal resection, resulting from an adaptation process that begins immediately to increase the mucosal surface area and absorption. Certain nutrients and trophic factors are widely used to increase intestinal adaptation following massive intestinal resection. The efficacy and benefits of glutamine on the intestinal adaptation process is still controversial. This study was conducted to determine the effects of parenteral glutamine administration on intestinal adaptation in a rat model of SBS. Fourteen male Wistar rats were divided into two groups; all 14 underwent 75% small bowel resection. Within each group, rats were assigned to 14 days of treatment with subcutaneous glutamine (0.3 g/kg/day) or isotonic saline daily. Weight changes and histological intestinal adaptation parameters (mucosal thickness, villus height, and crypt depth) were measured. Non-mucosal intestinal changes were evaluated by intestinal fractioned collagen analysis. All rats initially lost weight and began to gain weight postoperatively; however, they did not reach their preoperative weights during the experiment and there was no significant difference between the groups. Histological adaptation parameters were significantly increased after 75% intestinal resection in both groups compared to paired native samples (P<0.01); although the percent of increase was slightly higher in Gln group, no significant difference was detected between the two groups. Fractioned-collagen amounts were found to be similar between groups. The results indicated that parenteral glutamine administration alone does not improve the intestinal adaptation process after massive intestinal resection in rats.
Serum tumor necrosis factor-α, glutamate and lactate changes in two different stages of mechanical intestinal obstruction Turkish Journal of Gastroenterology, 2003
Comparison of the effects of propofol, isoflurane and sevoflurane on renin-angiotensin-aldosterone system in rabbits Turk Anesteziyoloji Ve Reanimasyon, 2001
RECENT SCHOLAR PUBLICATIONS
Therapeutic Potential of Tetrahydrocurcumin Against Multidrug-resistant Anaplastic Thyroid Cancer Cells M Ali, Y Kaya, H Ates, E Bildik, H Kocdor 2026
Phytochemical profile of Rheum ribes and modulation of invasion, metastasis, and angiogenesis in breast cancer cell line Y Kaya, H KOÇDOR, A YILDIRIM, F Zihnioglu, İ Kaya Tekbudak, K Tok, ... FEBS OPEN BIO 15 , 2025 2025
Isolation and efficiency assessment of adipose-derived mesenchymal stem cells A YILDIRIM, A Silistreli, E Bildik, H ATEŞ, H KOÇDOR FEBS OPEN BIO 15 , 2025 2025
Relationship between squamous cell carcinoma and paraoxonase-1 B Kocdor, A YILDIRIM, Y Kaya, O Gurbuz, H KOÇDOR FEBS OPEN BIO 15 , 2025 2025
The Effects of Tetrahydrocurcumin on Adriamycin and Taxane resistance in Anaplastic Thyroid Cancer Cells K MA, Y KAYA, H ATES, E BILDIK, H KOCDOR 2024
The Effects of Tetrahydrocurcumin on Adriamycin and Taxane resistance in Anaplastic Thyroid Cancer Cells MA KOCDOR, K Yagmur, A Halil, E BILDIK, H KOCDOR 2024
THE INVITATION D Yucel, H Kocdor TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI 48, 7-8 , 2024 2024
PANKREAS DUKTAL ADENOKARSİNOMUNDA İLAÇ DİRENCİNİN MOLEKÜLER TEMELLERİ, IN VITRO, EX VIVO VE IN VIVO PREKLİNİK MODELLEMELER Y Kaya, E Bildik, H Koçdor Acta Medica Nicomedia 7 (1), 136-147 , 2024 2024
Perspectives on Inflammation in Preclinical and Clinical Studies and Current Monitoring: Integration of Inflammation-in vitro Diagnostic Diagnosis, Application, Devices, and … H Koçdor, N Pabuççuoğlu, F Zihnioğlu Turkiye Klinikleri , 2024 2024
Sıvı Biyopsi: in vitro Diyagnostik Açıdan Klinik Uygulamalar, Sorunlar, Beklentiler, Düzenlemeler H KOÇDOR, A PABUÇÇUOĞLU, F ZİHNİOĞLU Turkiye Klinikleri Medical Oncology-Special Topics 16 (1), 1-5 , 2023 2023
Kanserde Tükürük Biyobelirteçleri H KOÇDOR, A YILDIRIM Turkiye Klinikleri Medical Oncology-Special Topics 16 (1), 68-78 , 2023 2023
Tükürük Biyopsisi ve Hastalıkların Tanısındaki Önemi H KOÇDOR, A YILDIRIM Turkiye Klinikleri Medical Oncology-Special Topics 16 (1), 52-67 , 2023 2023
SYMPOSIUM SCIENTIFIC ADVISORY BOARD [SEMPOZYUM BİLİMSEL DANIŞMA KURULU] A Ünlü, A Argon, AS Dinçel, A Pabuçcuoğlu, A Demirtaş, B Zengel, ... Turk J Biochem 48 (2) , 2023 2023
INVESTIGATION OF THE ANTIMETASTATIC POTENTIAL OF THYMBRA SPICATA IN HUMAN BREAST ADENOCARCINOMA CELLS COMBINED WITH STANDART CHEMOTHERAPY. T SALMAN, A YILDIRIM, MA KOCDOR, Y KAYA, Y SOYSAL, H KOCDOR Turkish Journal of Biochemistry/Turk Biyokimya Dergisi 47 , 2022 2022
COMPARISON OF THE EFFECTS OF PISTACIA VERA INNER SHELL OBTAINED FROM DIFFERENT REGIONS OF TURKEY ON OXIDATIVE STRESS AND PROLIFERATION IN INVASIVE BREAST CANCER CELL LINE. I GURKEBABCI, B KOCDOR, H ATES, H KOCDOR Turkish Journal of Biochemistry/Turk Biyokimya Dergisi 47 , 2022 2022
ANTIMETASTATIC POTENTIAL OF CURCUMIN IN ANAPLASTIC THYROID CANCER AND COMBINED ACTIVITY WITH DOCETAXEL. MA KOCDOR, Y Kaya, A YILDIRIM, H Koçdor Turkish Journal of Biochemistry/Turk Biyokimya Dergisi 47 , 2022 2022
INVESTIGATION OF THE EFFECT PISTACIA VERA FROM DIFFERENT REGIONS ON OXIDATIVE STRESS AND PROLIFERATION IN BREAST CANCER CELL LINE İ Gürkebabçı, B Kocdor, H Koçdor Journal of Advanced Research in Health Sciences 5 (S-1), 59-59 , 2022 2022
Türkiye Klinikleri Biyomedikal-Özel Konular SAĞLIK BİYOTEKNOLOJİSİ H KOÇDOR Türkiye Klinikleri , 2022 2022
Sağlık Biyoteknolojisi H Koçdor, N Pabuççuoğlu, F Zihnioğlu, F Girgin Sağın Türkiye Klinikleri Yayınevi , 2022 2022
COVID-19 Pandemisinde Biyoteknoloji Kullanımı H KOÇDOR, İ GÜRKEBABCI, D HARMANCI Turkiye Klinikleri Biomedical-Special Topics 3 (1), 154-168 , 2022 2022
MOST CITED SCHOLAR PUBLICATIONS
The effects of selenium against cerebral ischemia-reperfusion injury in rats S Özbal, G Erbil, H Koçdor, K Tuğyan, Ç Pekçetin, C Özoğul Neuroscience letters 438 (3), 265-269 , 2008 2008 Citations: 119
Irisin immunohistochemistry in gastrointestinal system cancers S Aydin, T Kuloglu, MR Ozercan, S Albayrak, S Aydin, U Bakal, M Yilmaz, ... Biotechnic & Histochemistry 91 (4), 242-250 , 2016 2016 Citations: 109
Zinc supplementation induces apoptosis and enhances antitumor efficacy of docetaxel in non-small-cell lung cancer H Kocdor, H Ates, S Aydin, R Cehreli, F Soyarat, P Kemanli, D Harmanci, ... Drug Design, Development and Therapy, 3899-3909 , 2015 2015 Citations: 64
Dokuz Eylül Üniversitesi Sağlık Bilimleri Enstitüsünde Lisansüstü eğitim kalitesinin arttırılması kapsamında öğrencilerin eğitime ilişkin görüşlerinin değerlendirilmesi N DEVEBAKAN, H Koçdor, B MUSAL, GÜL GÜNER AKDOĞAN Dokuz Eylül Üniversitesi Sosyal Bilimler Enstitüsü , 2003 2003 Citations: 34
Human chorionic gonadotropin (hCG) prevents the transformed phenotypes induced by 17 β-estradiol in human breast epithelial cells H Kocdor, MA Kocdor, J Russo, KE Snider, JE Vanegas, IH Russo, ... Cell biology international 33 (11), 1135-1143 , 2009 2009 Citations: 33
Improvement of colonic healing by preoperative rectal irrigation with short-chain fatty acids in rats given radiotherapy C Terzi, AI Sevinç, H Koçdor, G Oktay, H Alanyal, A Küpelioglu, G Ergör, ... Diseases of the colon & rectum 47 (12), 2184-2194 , 2004 2004 Citations: 32
Progressive increase of glucose transporter-3 (GLUT-3) expression in estrogen-induced breast carcinogenesis MA Kocdor, H Kocdor, JS Pereira, JE Vanegas, IH Russo, J Russo Clinical and Translational Oncology 15 (1), 55-64 , 2013 2013 Citations: 27
Toxicity induced by he chemical carcinogen 7, 12-dimethylbenz [a] anthracene and the protective effects of selenium in wistar rats H Kocdor, R Cehreli, MA Kocdor, B Sis, O Yilmaz, T Canda, B Demirkan, ... Journal of Toxicology and Environmental Health, Part A 68 (9), 693-701 , 2005 2005 Citations: 27
The effects of pentoxifylline on bacterial translocation after intestinal obstruction MA Kocdor, H Kocdor, Z Gulay, O Gokce Shock 18 (2), 148-151 , 2002 2002 Citations: 25
Effects of locally applied 5-fluorouracil on the prevention of postmastectomy seromas in a rat model MA Kocdor, D Kilic Yildiz, H Kocdor, T Canda, O Yilmaz, G Oktay, ... European Surgical Research 40 (3), 256-262 , 2008 2008 Citations: 22
Inhibition of cancer stem-like phenotype by curcumin and deguelin in CAL-62 anaplastic thyroid cancer cells MA Kocdor, H Cengiz, H Ates, H Kocdor Anti-Cancer Agents in Medicinal Chemistry-Anti-Cancer Agents) 19 (15), 1887-1898 , 2019 2019 Citations: 19
Ghrelin expression of endometrium hyperplasia and endometrioid carcinoma AF Dagli, S Aydin, H Kocdor, B Gurates, İ Sahin, Z Catak, MR Ozercan, ... Gynecological Endocrinology 27 (3), 199-204 , 2011 2011 Citations: 19
Chemopreventive efficacies of rosiglitazone, fenretinide and their combination against rat mammary carcinogenesis H Kocdor, MA Kocdor, T Canda, D Gurel, R Cehreli, O Yilmaz, ... Clinical and Translational Oncology 11 (4), 243-249 , 2009 2009 Citations: 18
A promising biomarker to distinguish benign and malignant renal tumors: ELABELA G Artas, T Kuloglu, AF Dagli, K Ugur, M Yardim, S Aydin, H Artas, ... Nigerian Journal of Clinical Practice 22 (3), 386-392 , 2019 2019 Citations: 14
Serum tumor necrosis factor-α, glutamate and lactate changes in two different stages of mechanical intestinal obstruction H Koçdor, MA Koçdor, H Astarcioğlu, M Fadiloğlu Turkish Journal of Gastroenterology 14 (2), 115-119 , 2003 2003 Citations: 14
The effects of vascular bed expansion in steatotic rat liver graft viability H Astarcioǧlu, S Karademir, K Atila, Ö Saǧol, H Koçdor, A Çoker, ... Transplant international 17 (4), 188-194 , 2004 2004 Citations: 8
Preventive effect of hCG on rat mammary carcinogenesis JE Vanegas, M Kocdor, JS Pereira, H Kocdor, J Russo, K Snider, F Sheriff, ... Proc Am Assoc Cancer Res 50, 2059a , 2009 2009 Citations: 5
Abstract# 2059: Mammary cancer prevention by short treatment with human chorionic gonadotropin J Vanegas, M Kocdor, J Pereira, H Kocdor, J Russo, K Snider, F Sheriff, ... Cancer Research 69 (9_Supplement), 2059-2059 , 2009 2009 Citations: 4
The effects of parenteral glutamine on intestinal adaptation in a rat model of short bowel syndrome AD Ucar, H Kocdor, AE Canda, SM Unlu, R Cehreli, MA Kocdor Central European journal of medicine 5 (1), 115-122 , 2010 2010 Citations: 3
ENDOKRİN, METABOLİK HASTALIKLAR ve in vitro DİYAGNOSTİK H Koçdor Dokuz Eylül Yayınları , 2019 2019 Citations: 2