Rosa Direito

Scopus Publications

Artificial ovaries and the future of women's health: Shaping novel functions
João Paulo Ruiz Lucio de Lima Parra, Rodrigo Paolo Flores Abuna, Maria Angélica Miglino, Letícia Bandiera Arantes, Lucas Fornari Laurindo, et al.
Translational Research, 2026
Development and Characterization of Mesembryanthemum crystallinum L. Extract-Loaded Phytosomes for Enhanced Delivery of Antioxidant Compounds
Irina Fernandes, Ana Iglesias-Mejuto, João M. P. Coelho, Rosa Direito, Catarina P. Reis
Life, 2026
M. crystallinum is an edible halophytic succulent plant rich in phenolic compounds with potential pharmaceutical applications. However, it is known that these phytocompounds generally present low absorption, which hinders their direct use in formulations. Therefore, delivery systems, such as phytosomes, can be regarded as a potential strategy to overcome this disadvantage. This study aimed, for the first time, to prepare extracts from the ice plant using different solvents and to incorporate them into phytosomes. Physicochemical characterization of these phytosomes, their antioxidant activity, as well as the quantification and in vitro release profile of their phenolic and flavonoid compounds were studied. Different extraction solvents were assayed, and Ethanol:Acetone (80:20) achieved a strong antioxidant activity (reaching ca. 71.16%), extracting 3200.3 mg of GAE/100 g and 761.7 mg of QE/100 g of phenolic and flavonoid compounds, respectively. The phytosomal formulation exhibited a mean particle size of 233.80 nm, a polydispersity index of 0.23, and a zeta potential of −27.27 mV. Furthermore, a high encapsulation efficiency (96.63%) of the extracts in the phytosomes was obtained. The in vitro release test indicated that the antioxidant activity was retained, reaching a maximum of 42%, accompanied by a release of 51% of the flavonoid content at the end of the 3 h assay, under the experimental conditions. These findings highlight the potential of phytosomes formulated with Mesembryanthemum crystallinum extract as a delivery system for antioxidant phytochemicals.
Bridging the Gut Microbiota and the Brain, Kidney, and Cardiovascular Health: The Role of Probiotics
Milena Rosa Lopes, Rosa Direito, Elen Landgraf Guiguer, Vitor Cavallari Strozze Catharin, Tereza Lais Menegucci Zutin, et al.
Probiotics and Antimicrobial Proteins, 2026
The symbiosis between intestinal bacteria and the human body’s physiological processes can modulate health. The intestinal microbiota is linked to the development of neurotrophic factors; therefore, it is increasingly related to the modulation of nervous system pathologies. Moreover, microbiota can interfere with inflammation and oxidative stress, which are closely linked to cardiovascular risk factors and several other inflammatory conditions, such as kidney and neurodegenerative diseases. Probiotics are live microorganisms that help regulate and maintain healthy microbiota; thus, they can help prevent these diseases. Due to these reasons, this review aimed to evaluate the effects of probiotics on the gut, kidneys, brain, and heart homeostasis. Clinical trials showed several positive results with the treatment. In the brain, probiotics reduce depressive symptoms (decreases in HAMA, GAD-7, and BDI-II scales), improving patients’ sleep quality and fatigue, enhancing cognitive subscales while slowing brain atrophy, and reducing IL-6 levels in the central areas, also modulating REM delta power to reduce high-frequency brain waves. Probiotics can also reduce cardiovascular risk factors, such as inflammation. Probiotics can also benefit the heart by decreasing TMAO, LDL-c, TG, CRP, MDA, TNF-α, IL-6, and urea levels, improving dyslipidemia and toxin profiles. Probiotics also increase HDL-c, ApoE, and insulin sensitivity, decreasing BMI, body fat, and the risk of developing chronic hyperglycemia while increasing lean mass. Besides, probiotic supplementation helped reduce toxic uremic toxins (serum urea) and sodium levels, bringing benefits to the kidneys, and improve energy/amino acid metabolism. Probiotics can also modulate and enhance kidney function due to decreased pro-inflammatory TGFβ-1 and TNF-α levels and RUNX2. Furthermore, enhanced gastrointestinal motility and diversity have been reported using specific bacteria. Although probiotics can bring several health benefits, there are still challenges regarding these supplements, such as dose, frequency, and pharmaceutical formula. Therefore, new studies are welcome to deepen the understanding of these microorganisms.
Oral Salvia officinalis phenolics abolish mortality and mitigate inflammation in acute TNBS murine colitis
Rosa Direito, João Rocha, Inês Alves de Melo, Margarida Gonçalves, Maria Paula Duarte, et al.
Fitoterapia, 2025
Catalpol: An Iridoid Glycoside With Potential in Combating Cancer Development and Progression—A Comprehensive Review
Lucas Fornari Laurindo, Victória Dogani Rodrigues, Elen Landgraf Guiguer, Lívia Fornari Laurindo, Debora Aparecida Pires de Campos Zuccari, et al.
Phytotherapy Research, 2025
Catalpol, a natural iridoid glycoside known for its anti‐proliferative effects, has been proposed as an anticancer compound. Catalpol targets critical processes involved in cancer cell progression, like malignant proliferation, apoptosis, and metastasis. Additionally, catalpol presents potent anti‐inflammatory and antioxidant properties crucial for cancer prevention and intervention. Due to the absence of clinical trials, this review investigates twelve studies, encompassing in vitro and animal trials from reputable databases, such as PubMed, with no time restrictions. Therefore, we covered evidence from catalpol's effects against several types of cancer, including breast, liver, colorectal, lung, gastric, bladder, and ovarian cancer, as well as osteosarcoma, and assessed various outcomes related to cell viability, apoptosis, migration, and modulation of molecular mechanisms by catalpol. Notably, catalpol induced cancer cell death via induction of mitochondrial apoptosis pathways, regulation of the expression of specific microRNAs, modulation of Sirt1, Kras, RACK1, PARP, PI3K/Akt, Bcl‐2, and STAT3/JAK2/Src signaling pathways, and inactivation of NF‐kB and Smad 2/3 signaling pathways. Furthermore, catalpol limits cancer metastasis due to modulation of critical metalloproteinases associated with cancer migration. Catalpol also synergizes with chemotherapeutic and adjuvant agents to induce cancer control, including regorafenib in liver cancer and chloroquine in gastric cancer, promoting increased anticancer action via upregulated cancer cell apoptosis, decreased proliferation, and inhibited angiogenesis via PI3K/p‐Akt/mTOR/NF‐κB, VEGF/VEGFR2, and Bax signaling pathways modulation. Catalpol derivatives also gained attention. Pyrazole‐, imidazole‐, and hydrolyzed‐based catalpol derivatives increase cancer cell apoptosis and death and decrease tumor angiogenesis through similar pathways. This review seeks to provide understanding of catalpol's anticancer effects, its mechanisms of action, and its potential as a therapeutic anticancer agent while advocating for future research conductance.
Advances in Understanding Long COVID: Pathophysiological Mechanisms and the Role of Omics Technologies in Biomarker Identification
Mônica Duarte da Silva, Thamires Santos da Silva, Claudemir Gregório Mendes, Maria Carolina Miglino Valbão, Abraham Kwame Badu-Tawiah, et al.
Molecular Diagnosis and Therapy, 2025
AdipoRon as a Novel Therapeutic Agent for Depression: A Comprehensive Review of Preclinical Evidence
Lucas Fornari Laurindo, Victória Dogani Rodrigues, Rodrigo Haber Mellen, Rafael Santos de Argollo Haber, Vitor Engrácia Valenti, et al.
Biomedicines, 2025
Background/Objectives: Depression is a mood disorder that causes persistent sadness and loss of interest, and its etiology involves a condition known as hypoadiponectinemia, which is prevalent in depressive individuals compared with healthy individuals and causes neuroinflammation. The use of intact adiponectin protein to target neuroinflammation in depressive moods is complex due to the difficulties associated with using the intact protein. AdipoRon, a synthetic oral adiponectin receptor agonist that targets the AdipoR1 and AdipoR2 receptors for adiponectin, has emerged in this context. Its most prominent effects include reduced inflammation and the attenuation of oxidative stress. To the best of our knowledge, no comprehensive review has addressed these results so far. To fill this literature gap, we present a comprehensive review examining the effectiveness of AdipoRon in treating depression. Methods: Only preclinical models are included due to the absence of clinical studies. Results: Analyzing the included studies shows that AdipoRon demonstrates contrasting effects against depression. However, most of the evidence underscores AdipoRon-based adiponectin replacement therapies as potential candidates for future treatment against this critical psychiatric condition due to their anti-neuroinflammatory potential, ultimately inhibiting several neuroinflammatory pathways. Conclusions: Future research endeavors must address several limitations due to the heterogeneity of the studies’ methodologies and results.
Targeting Muscle Regeneration with Small Extracellular Vesicles from Adipose Tissue-Derived Stem Cells—A Review
Lucas Fornari Laurindo, Enzo Pereira de Lima, Adriano Cressoni Araújo, Victória Dogani Rodrigues, Jefferson Aparecido Dias, et al.
Cells, 2025
Extracellular vesicles (EVs) are membrane-bound structures released by cells carrying diverse biomolecules involved in intercellular communication. Small EVs are abundant in body fluids, playing a key role in cell signaling. Their natural occurrence and therapeutic potential, especially in the context of muscular disorders, make them a significant area of research. Sarcopenia, characterized by progressive muscle fiber loss, represents a pathological state in which EVs could offer therapeutic benefits, reducing morbidity and mortality. Recent studies have proposed an interplay between adipose tissue (AT) and skeletal muscle regarding sarcopenia pathology. AT dysregulation, as seen in obesity, contributes to skeletal muscle loss in a multifactorial way. While AT-derived stem cell (ATDSC) small EVs have been implicated in musculoskeletal homeostasis, their precise action in muscle regeneration remains incompletely understood. In this context, ATDSC-derived small EVs can stimulate skeletal muscle regeneration through improved proliferation and migration of muscle cells, enhancement of muscular perfusion, improvement of tendon and nerve regeneration, stimulation of angiogenesis, and promotion of myogenic differentiation. However, they can also increase skeletal muscle loss. Notably, this is the first comprehensive review to systematically examine the role of ATDSC-derived small EVs in sarcopenia.
Unraveling the Metabolic Pathways Between Metabolic-Associated Fatty Liver Disease (MAFLD) and Sarcopenia
Marina Ribas Losasso, Maria Luiza Cesto Parussolo, Antony Oliveira Silva, Rosa Direito, Karina Quesada, et al.
International Journal of Molecular Sciences, 2025
Metabolic-Associated Fatty Liver Disease (MAFLD) is a public health concern that is constantly expanding, with a fast-growing prevalence, and it affects about a quarter of the world’s population. This condition is a significant risk factor for cardiovascular, hepatic, and oncologic diseases, such as hypertension, hepatoma, and atherosclerosis. Sarcopenia was long considered to be an aging-related syndrome, but today, it is acknowledged to be secondarily related to chronic diseases such as metabolic syndrome, cardiovascular conditions, and liver diseases, among other comorbidities associated with insulin resistance and chronic inflammation, besides inactivity and poor nutrition. The physiopathology involving MAFLD and sarcopenia has still not been solved. Inflammation, oxidative stress, mitochondrial dysfunction, and insulin resistance seem to be some of the keys to this relationship since this hormone target is mainly the skeletal muscle. This review aimed to comprehensively discuss the main metabolic and physiological pathways involved in these conditions. MAFLD and sarcopenia are interconnected by a complex network of pathophysiological mechanisms, such as insulin resistance, skeletal muscle tissue production capacity, chronic inflammatory state, oxidative stress, and mitochondrial dysfunction, which are the main contributors to this relationship. In addition, in a clinical analysis, patients with sarcopenia and MAFLD manifest more severe hepatitis fibrosis when compared to patients with only MAFLD. These patients, with both disorders, also present clinical improvement in their MAFLD when treated for sarcopenia, reinforcing the association between them. Lifestyle changes accompanied by non-pharmacological interventions, such as dietary therapy and increased physical activity, undoubtedly improve this scenario.
Assessing Omega-3 Therapy and Its Cardiovascular Benefits: What About Icosapent Ethyl? A Systematic Review and Meta-Analysis
Nathália Mendes Machado, Maria Vitória Barroso Oliveira, Karina Quesada, Jesselina Francisco dos Santos Haber, Ricardo José Tofano, et al.
Pharmaceuticals, 2025
Background: Lipid-lowering therapies are an option for stabilizing lipid levels. Icosapent ethyl (IPE) is a highly purified formulation of eicosapentaenoic acid, which can reduce lipid action, improve plaque stabilization, reduce platelet aggregation, lower TG, and prevent cardiovascular events. IPE is frequently used with statins to manage elevated TG levels. However, the evidence on IPE as a lipid-lowering agent is limited, and no updated systematic review and meta-analysis have been published considering the recent advancements in the field and newly published studies. Therefore, we aim to fill this gap. Methods: We used the PRISMA guidelines and the PICO (Population, Intervention, Comparison, and Outcome) framework to conduct this review, aiming to answer the question, “Can IPE benefit patients at cardiovascular risk?” GRADE was used to evaluate evidence levels to adhere to the highest criteria. Results: Predominantly, the evaluated population presented TG levels between ≥135 mg/dL and 500 mg/dL and LDL-C levels between >40 mg/dL and ≤100 mg/dL. The included studies showed a reduction in TG and LDL-C and a decrease in cardiovascular events. It means that, according to our systematic review evidence analysis, IPE has been effective in lowering blood lipid levels, including TG, and reducing cardiovascular death and events, such as non-fatal stroke or hospitalization for unstable angina. However, it is worth noting that these results were primarily from patients undergoing statin therapy. According to our meta-analysis, IPE may not be considered a lipid-lowering drug, as limited action associated with its use was evident in the quantitative results. However, caution is necessary, as only two studies were suitable for inclusion due to the differing outcomes in the analyzed samples. Conclusions: Despite the quantitative synthesis, IPE possesses anti-inflammatory, anti-thrombotic, and anti-atherogenic properties, highly related to cardiovascular protection. Based on our included studies, IPE was considered a promising therapy for atherosclerotic cardiovascular disease in conjunction with other lipid-lowering therapies, particularly statins, for patients with extremely high TG levels. The limitations of the reviewed studies may include small sample sizes, varying outcomes, and a small duration of interventions. Future clinical trials with similar outcomes, sample sizes, and intervention durations must be designed, and updated meta-analyses must be published in the following years to fully assess the effects of IPE as a lipid-lowering and cardiovascular protector drug.
Polyphenols, Alkaloids, and Terpenoids Against Neurodegeneration: Evaluating the Neuroprotective Effects of Phytocompounds Through a Comprehensive Review of the Current Evidence
Enzo Pereira de Lima, Lucas Fornari Laurindo, Vitor Cavallari Strozze Catharin, Rosa Direito, Masaru Tanaka, et al.
Metabolites, 2025
Melatonin from Plants: Going Beyond Traditional Central Nervous System Targeting—A Comprehensive Review of Its Unusual Health Benefits
Lucas Fornari Laurindo, Otávio Augusto Garcia Simili, Adriano Cressoni Araújo, Elen Landgraf Guiguer, Rosa Direito, et al.
Biology, 2025
Phytosomal delivery enhances bioactivity of Hylocereus costaricensis phenolic extract
Frontiers in Nutrition, 2025
Evaluating the effects of seed oils on lipid profile, inflammatory and oxidative markers, and glycemic control of diabetic and dyslipidemic patients: a systematic review of clinical studies
Lucas Fornari Laurindo, Lívia Fornari Laurindo, Victória Dogani Rodrigues, Jéssica da Silva Camarinha Oliveira, Beatriz Leme Boaro, et al.
Frontiers in Nutrition, 2025
Targeting AMPK with Irisin: Implications for metabolic disorders, cardiovascular health, and inflammatory conditions — A systematic review
Lucas Fornari Laurindo, Victória Dogani Rodrigues, Lívia Fornari Laurindo, Luana Maria Amaral Cherain, Enzo Pereira de Lima, et al.
Life Sciences, 2025
Isoorientin: Unveiling the hidden flavonoid's promise in combating cancer development and progression – A comprehensive review
Lucas Fornari Laurindo, Karina Torres Pomini, Enzo Pereira de Lima, Lívia Fornari Laurindo, Victória Dogani Rodrigues, et al.
Life Sciences, 2025
Health benefits of acerola (Malpighia spp) and its by-products: A comprehensive review of nutrient-rich composition, pharmacological potential, and industrial applications
Lucas Fornari Laurindo, Larissa Naomi Takeda, Nathalia Mendes Machado, Alda Maria Machado Bueno Otoboni, Ricardo de Alvares Goulart, et al.
Food Bioscience, 2024
The therapeutic potential of bee venom-derived Apamin and Melittin conjugates in cancer treatment: A systematic review
Lucas Fornari Laurindo, Enzo Pereira de Lima, Lívia Fornari Laurindo, Victória Dogani Rodrigues, Eduardo Federighi Baisi Chagas, et al.
Pharmacological Research, 2024
Exploring Lectin Bioactivity and Total Phenolic Compounds in Kiwifruit (Actinidia deliciosa var. Hayward)
Raquel Rodrigues, Maria Eduardo Figueira, Rosa Direito, Andreia Bento-Silva, Ricardo Boavida Ferreira, et al.
Nutrients, 2024
Exploring the Impact of Catechins on Bone Metabolism: A Comprehensive Review of Current Research and Future Directions
Iris Jasmin Santos German, Sandra Maria Barbalho, Jesus Carlos Andreo, Tereza Lais Menegucci Zutin, Lucas Fornari Laurindo, et al.
Metabolites, 2024
Metabolic-Associated Fatty Liver Disease: The Influence of Oxidative Stress, Inflammation, Mitochondrial Dysfunctions, and the Role of Polyphenols
Raissa Bulaty Tauil, Paula Takano Golono, Enzo Pereira de Lima, Ricardo de Alvares Goulart, Elen Landgraf Guiguer, et al.
Pharmaceuticals, 2024
Ginkgo biloba: A Leaf of Hope in the Fight against Alzheimer’s Dementia: Clinical Trial Systematic Review
Guilherme Lopes de Oliveira Pagotto, Livia Maria Oliveira dos Santos, Najwa Osman, Caroline Barbalho Lamas, Lucas Fornari Laurindo, et al.
Antioxidants, 2024
Plant-Derived Bioactive Compounds: Exploring Neuroprotective, Metabolic, and Hepatoprotective Effects for Health Promotion and Disease Prevention
Rosa Direito, Sandra Maria Barbalho, Bruno Sepodes, Maria Eduardo Figueira
Pharmaceutics, 2024
Investigating the Neuroprotective and Cognitive-Enhancing Effects of Bacopa monnieri: A Systematic Review Focused on Inflammation, Oxidative Stress, Mitochondrial Dysfunction, and Apoptosis
Luiz José Valotto Neto, Matheus Reverete de Araujo, Renato Cesar Moretti Junior, Nathalia Mendes Machado, Rakesh Kumar Joshi, et al.
Antioxidants, 2024
Grape Processing Waste: Effects on Inflammatory Bowel Disease and Colorectal Cancer
Lucas Fornari Laurindo, Rosa Direito, Alda M. M. Bueno Otoboni, Ricardo Alvares Goulart, Karina Quesada, et al.
Food Reviews International, 2024
Rhodiola rosea L. Extract, a Known Adaptogen, Evaluated in Experimental Arthritis
Frantisek Drafi, Katarina Bauerova, Martin Chrastina, Mohsen Taghdisiesfejír, João Rocha, et al.
Molecules, 2023
Medicinal Plants, Phytochemicals and Regulation of the NLRP3 Inflammasome in Inflammatory Bowel Diseases: A Comprehensive Review
Rosa Direito, Sandra Maria Barbalho, Maria Eduardo Figueira, Giulia Minniti, Gabriel Magno de Carvalho, et al.
Metabolites, 2023
Curcumin-Based Nanomedicines in the Treatment of Inflammatory and Immunomodulated Diseases: An Evidence-Based Comprehensive Review
Lucas Fornari Laurindo, Gabriel Magno de Carvalho, Bárbara de Oliveira Zanuso, Maria Eduardo Figueira, Rosa Direito, et al.
Pharmaceutics, 2023
Anti-Inflammatory, Antioxidant, and Other Health Effects of Dragon Fruit and Potential Delivery Systems for Its Bioactive Compounds
Daniela Franceschi Nishikito, Ana Claudia Abdalla Borges, LUCAS FORNARI LAURINDO, Alda M. M. Bueno Otoboni, R. Direito, et al.
Pharmaceutics, 2023
Anthocyanins: Metabolic Digestion, Bioavailability, Therapeutic Effects, Current Pharmaceutical/Industrial Use, and Innovation Potential
Huseyin Ayvaz, Turgut Cabaroglu, Asiye Akyildiz, Cigdem Uysal Pala, Riza Temizkan, et al.
Antioxidants, 2023
Ginkgo biloba in the Aging Process: A Narrative Review
Sandra Maria Barbalho, Rosa Direito, Lucas Fornari Laurindo, Ledyane Taynara Marton, Elen Landgraf Guiguer, et al.
Antioxidants, 2022
Lupinus albus protein components inhibit MMP-2 and MMP-9 gelatinolytic activity in vitro and in vivo
Joana Mota, Rosa Direito, João Rocha, João Fernandes, Bruno Sepodes, et al.
International Journal of Molecular Sciences, 2021
From diospyros kaki L. (persimmon) phytochemical profile and health impact to new product perspectives and waste valorization
Rosa Direito, João Rocha, Bruno Sepodes, Maria Eduardo-Figueira
Nutrients, 2021
Phenolic compounds impact on rheumatoid arthritis, inflammatory bowel disease and microbiota modulation
Rosa Direito, João Rocha, Bruno Sepodes, Maria Eduardo-Figueira
Pharmaceutics, 2021
Attenuation of colonic injury and inflammation by administration of a phenolic extract of summer savory (Satureja hortensis l.) in experimental inflammatory bowel disease in mice
João Rocha, Raquel Leandro, Rosa Direito, Margarida Gonçalves, Maria Paula Duarte, et al.
Applied Sciences Switzerland, 2020
Anti-inflammatory Effects of Persimmon (Diospyros kaki L.) in Experimental Rodent Rheumatoid Arthritis
Rosa Direito, João Rocha, Ana-Teresa Serra, Adelaide Fernandes, Marisa Freitas, et al.
Journal of Dietary Supplements, 2020
Anti-inflammatory activity of grapefruit juice in an in vivo model of ulcerative colitis: Comparability studies of unprocessed and bioprocessed juices
Carla Mendes, João Rocha, Rosa Direito, Adelaide Fernandes, Bruno Sepodes, et al.
Journal of Functional Foods, 2019
Reduction of inflammation and colon injury by a Pennyroyal phenolic extract in experimental inflammatory bowel disease in mice
João Rocha, Rosa Direito, Ana Lima, Joana Mota, Margarida Gonçalves, et al.
Biomedicine and Pharmacotherapy, 2019
Phytosomes with persimmon (Diospyros kaki l.) extract: Preparation and preliminary demonstration of in vivo tolerability
Rosa Direito, Catarina Reis, Luís Roque, Margarida Gonçalves, Ana Sanches-Silva, et al.
Pharmaceutics, 2019
Combination of hyaluronic acid and PLGA particles as hybrid systems for viscosupplementation in osteoarthritis
Ana Henriques Mota, Rosa Direito, Marta P. Carrasco, Patrícia Rijo, Lia Ascensão, et al.
International Journal of Pharmaceutics, 2019
Anti-inflammatory effect of limonin from cyclodextrin (un)processed orange juices in in vivo acute inflammation and chronic rheumatoid arthritis models
Susana A. Vieira da Silva, Ana Clemente, João Rocha, Rosa Direito, Helena Cabral Marques, et al.
Journal of Functional Foods, 2018
Dyospiros kaki phenolics inhibit colitis and colon cancer cell proliferation, but not gelatinase activities
Rosa Direito, Ana Lima, João Rocha, Ricardo Boavida Ferreira, Joana Mota, et al.
Journal of Nutritional Biochemistry, 2017
Protective effects of a blueberry extract in acute inflammation and collagen-induced arthritis in the rat
Maria-Eduardo Figueira, Mónica Oliveira, Rosa Direito, João Rocha, Paula Alves, et al.
Biomedicine and Pharmacotherapy, 2016
Protective effects of hydroxytyrosol-supplemented refined olive oil in animal models of acute inflammation and rheumatoid arthritis
S. Silva, B. Sepodes, J. Rocha, R. Direito, A. Fernandes, et al.
Journal of Nutritional Biochemistry, 2015
Chemical characterization of a red raspberry fruit extract and evaluation of its pharmacological effects in experimental models of acute inflammation and collagen-induced arthritis
M. E. Figueira, M. B. Câmara, R. Direito, J. Rocha, A. T. Serra, et al.
Food and Function, 2014
Enantioselective assay for therapeutic drug monitoring of eslicarbazepine acetate: No interference with carbamazepine and its metabolites
Gilberto Alves, Ana Fortuna, Joana Sousa, Rosa Direito, Anabela Almeida, et al.
Therapeutic Drug Monitoring, 2010

MOST CITED SCHOLAR PUBLICATIONS

Anthocyanins: Metabolic digestion, bioavailability, therapeutic effects, current pharmaceutical/industrial use, and innovation potential
H Ayvaz, T Cabaroglu, A Akyildiz, CU Pala, R Temizkan, E Ağçam, ...
Antioxidants 12 (1), 48 , 2022
2022
Citations: 184
Anti-inflammatory, antioxidant, and other health effects of dragon fruit and potential delivery systems for its bioactive compounds
DF Nishikito, ACA Borges, LF Laurindo, AMMB Otoboni, R Direito, ...
Pharmaceutics 15 (1), 159 , 2023
2023
Citations: 156
Ginkgo biloba in the Aging Process: A Narrative Review
SM Barbalho, R Direito, LF Laurindo, LT Marton, EL Guiguer, RA Goulart, ...
Antioxidants 11 (3), 525 , 2022
2022
Citations: 128
Investigating the Neuroprotective and Cognitive-Enhancing Effects of Bacopa monnieri : A Systematic Review Focused on Inflammation, Oxidative Stress …
LJ Valotto Neto, M Reverete de Araujo, RC Moretti Junior, ...
Antioxidants 13 (4), 393 , 2024
2024
Citations: 117
Protective effects of hydroxytyrosol-supplemented refined olive oil in animal models of acute inflammation and rheumatoid arthritis
S Silva, B Sepodes, J Rocha, R Direito, A Fernandes, D Brites, M Freitas, ...
The Journal of nutritional biochemistry 26 (4), 360-368 , 2015
2015
Citations: 113
Curcumin-based nanomedicines in the treatment of inflammatory and immunomodulated diseases: an evidence-based comprehensive review
LF Laurindo, GM de Carvalho, B de Oliveira Zanuso, ME Figueira, ...
Pharmaceutics 15 (1), 229 , 2023
2023
Citations: 112
Investigating the neuroprotective and cognitive-enhancing effects of Bacopa monnieri: a systematic review focused on inflammation, oxidative stress, mitochondrial dysfunction …
LJV Neto, MR de Araujo, RCM Junior, NM Machado, RK Joshi, ...
Antioxidants 13 (4), 393 , 2024
2024
Citations: 99
Polyphenols, alkaloids, and terpenoids against neurodegeneration: evaluating the neuroprotective effects of phytocompounds through a comprehensive review of the current evidence
EP de Lima, LF Laurindo, VCS Catharin, R Direito, M Tanaka, ...
Metabolites 15 (2), 124 , 2025
2025
Citations: 85
Phenolic compounds impact on rheumatoid arthritis, inflammatory bowel disease and microbiota modulation
R Direito, J Rocha, B Sepodes, M Eduardo-Figueira
Pharmaceutics 13 (2), 145 , 2021
2021
Citations: 76
From Diospyros kaki L. (Persimmon) Phytochemical Profile and Health Impact to New Product Perspectives and Waste Valorization
R Direito, J Rocha, B Sepodes, M Eduardo-Figueira
Nutrients 13 (9), 3283 , 2021
2021
Citations: 75
Phytosomes with Persimmon ( Diospyros kaki L.) Extract: Preparation and Preliminary Demonstration of In Vivo Tolerability
R Direito, C Reis, L Roque, M Gonçalves, A Sanches-Silva, MM Gaspar, ...
Pharmaceutics 11 (6), 296 , 2019
2019
Citations: 75
Ginkgo biloba : A Leaf of Hope in the Fight against Alzheimer’s Dementia: Clinical Trial Systematic Review
GLO Pagotto, LMO Santos, N Osman, CB Lamas, LF Laurindo, KT Pomini, ...
Antioxidants 13 (6), 651 , 2024
2024
Citations: 69
Chemical characterization of a red raspberry fruit extract and evaluation of its pharmacological effects in experimental models of acute inflammation and collagen-induced arthritis
ME Figueira, MB Câmara, R Direito, J Rocha, AT Serra, CMM Duarte, ...
Food & function 5 (12), 3241-3251 , 2014
2014
Citations: 66
Metabolic-associated fatty liver disease: the influence of oxidative stress, inflammation, mitochondrial dysfunctions, and the role of polyphenols
RB Tauil, PT Golono, EP de Lima, R de Alvares Goulart, EL Guiguer, ...
Pharmaceuticals 17 (10), 1354 , 2024
2024
Citations: 61
Protective effects of a blueberry extract in acute inflammation and collagen-induced arthritis in the rat
ME Figueira, M Oliveira, R Direito, J Rocha, P Alves, AT Serra, C Duarte, ...
Biomedicine & Pharmacotherapy 83, 1191-1202 , 2016
2016
Citations: 59
Dyospiros kaki phenolics inhibit colitis and colon cancer cell proliferation, but not gelatinase activities
R Direito, A Lima, J Rocha, RB Ferreira, J Mota, P Rebelo, A Fernandes, ...
The Journal of Nutritional Biochemistry 46, 100-108 , 2017
2017
Citations: 58
Combination of hyaluronic acid and PLGA particles as hybrid systems for viscosupplementation in osteoarthritis
AH Mota, R Direito, MP Carrasco, P Rijo, L Ascensão, AS Viana, J Rocha, ...
International journal of pharmaceutics 559, 13-22 , 2019
2019
Citations: 49
Plant-derived bioactive compounds: exploring neuroprotective, metabolic, and hepatoprotective effects for health promotion and disease prevention
R Direito, SM Barbalho, B Sepodes, ME Figueira
Pharmaceutics 16 (5), 577 , 2024
2024
Citations: 35
Anti-inflammatory Effects of Persimmon ( Diospyros kaki L.) in Experimental Rodent Rheumatoid Arthritis
R Direito, J Rocha, AT Serra, A Fernandes, M Freitas, E Fernandes, ...
Journal of dietary supplements 17 (6), 663-683 , 2020
2020
Citations: 34
Medicinal plants, phytochemicals and regulation of the NLRP3 inflammasome in inflammatory bowel diseases: a comprehensive review
R Direito, SM Barbalho, ME Figueira, G Minniti, GM de Carvalho, ...
Metabolites 13 (6), 728 , 2023
2023
Citations: 33

Rosa Direito

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RECENT SCHOLAR PUBLICATIONS

MOST CITED SCHOLAR PUBLICATIONS