Abdullah Levent ALPARSLAN

Scopus Publications

A Comprehensive Study on Peppermint Oil and Cinnamon Oil as Nanoemulsion: Preparation, Stability, Cytotoxicity, Antimicrobial, Antifungal, and Antioxidant Activity
Emrah Özakar, Levent Alparslan, M. Cemal Adıgüzel, Gülşah Torkay, Alper Baran, Ayça Bal-Öztürk, and Rukiye Sevinç-Özakar
Bentham Science Publishers Ltd.
Background: Recent studies have shown that nanoemulsions prepared with essential oils have significant antimicrobial potential against multidrug-resistant pathogens due to increased chemical stability. Nanoemulsion also promotes controlled and sustained release, which increases their bioavailability and efficacy against multidrug-resistant bacteria. Objective: This study aimed to investigate the antimicrobial, antifungal, antioxidant, and cytotoxicity properties of cinnamon essential oil and peppermint essential oil as nanoemulsions compared to pure forms. For this purpose, analyses of the selected stable nanoemulsions were carried out. Method: The droplet sizes and zeta potentials of peppermint essential oil nanoemulsions and cinnamon essential oil nanoemulsions were found to be 154.6±1.42 nm and -17.1±0.68 mV and 200.3±4.71 nm and -20.0±0.81 mV, respectively. Although the amount of essential oil used in nanoemulsions was 25% w/w, antioxidant and antimicrobial activities were found to be more effective compared to pure essential oils. Results: In cytotoxicity studies on the 3T3 cell line, both essential oil nanoemulsions showed higher cell viability than pure essential oils. At the same time, cinnamon essential oil nanoemulsions exhibited a higher antioxidant property than peppermint essential oil nanoemulsions and showed superiority in the antimicrobial susceptibility test conducted against four bacteria and two fungi. Cell viability tests determined that cinnamon essential oil nanoemulsions showed considerably higher cell viability compared to pure cinnamon essential oil. Conclusion: These findings indicated that the prepared nanoemulsions in the current study might positively influence the dosing regimen and clinical outcomes of antibiotic therapy.

Antibacterial and anthelmintic effect of the combination of pomegranate peel and olive leaf extracts
Levent Alparslan, Betul Giray, Meltem Gulec, Nil Kaya, Dogan Uvey, and Abdullah Olgun
Acta Pharmaceutica Sciencia

Sodium hyaluronate dry powder inhalation in combination with sodium cromoglycate prepared using optimized spray drying conditions
Gülbeyaz Yildiz Türkyilmaz, Kemal Volkan Özdokur, Levent Alparslan, and Ercüment Karasulu
Informa UK Limited
Sodium hyaluronate (SHA) is an anti-inflammatory and protective agent against bronchoconstriction, and sodium cromoglicate (SCG) prevents exercise-induced bronchoconstriction and inflammation. Based on the pharmacological properties of both substances, this study aimed to develop a dry powder inhaler (DPI) of SHA alone and in combination with SCG. The target of the study was to develop flowable formulations without any surfactants by using the spray drying method. To obtain respirable SHA and SCG:SHA particles, variables of the spray dryer, such as inlet temperature, atomized air flow, and feed solution, were changed. The particles 1-8 μm in size were produced with high yield by spray drying and increasing the ethanol percentage of the feed solution (60%), which is the most remarkable parameter. After that, physicochemical characterizations were performed. The aerosol performance of DPI formulations prepared using lactose was evaluated using Handihaler® DPI. The fine particle fraction (FPF) was 36% for the SHA formulation, whereas it was 52 and 53% for SCG and SHA, respectively, in the SCG:SHA formulation. Consequently, both particles were produced reproducibly by spray drying, and inhaled SHA and SCG:SHA dry powder formulations were developed due to their high FPF and flowability with lactose.

Places of microemulsion and emulsion in cancer therapy: In vitro and in vivo evaluation
M. Fanun
CRC Press
A Phase Diagram Approach to Microemulsions, S.E. Friberg and P.A. Aikens Physicochemistry of W/O Microemulsions: Formation, Stability, and Droplet Clustering, A.K. Rakshit and S.P. Moulik Percolating Phenomenon in Microemulsions: Effect of External Entity, S.K. Mehta, K. Kaur, G. Kaur, and K.K. Bhasin Influence of Polyethylene Glycols and Polyethylene Glycol Dimethyl Ethers upon the Internal Dynamics of Water in Oil Microemulsions, A. Cid, L. Garcia-Rio, D. Gomez-Diaz, and J.C. Mejuto Microemulsions with Mixed Nonionic Surfactants, M. Fanun Simple Alcohols and Their Role in the Structure and Interactions of Microemulsion Systems, M. Tomsic and A. Jamnik Formation and Characterization of Emulsified Microemulsions, A. Yaghmur, L. de Campo, and O. Glatter Dynamics of Solvent and Rotational Relaxation of RTILs in RTILs-Containing Microemulsions, D. Seth and N. Sarkar Microemulsion Systems and Their Potential as Drug Carriers, R.G. Alany, G.M.M. El Maghraby, K. Krauel-Goellner, and A. Graf Physicochemical Characterization of Pharmaceutically Applicable Microemulsions: Tween 40/Imwitor 308/Isopropyl Myristate/Water, M. Gasperlin and M. Bester-Rogac Places of Microemulsion and Emulsion in Cancer Therapy: In Vitro and In Vivo Evaluation, E. Karasulu, B. Karaca, L. Alparslan, and H.Y. Karasulu Enzyme Kinetics as a Useful Probe for Micelle and Microemulsion Structure and Dynamics, W. Kunz, D. Touraud, and P. Bauduin Biocatalysis in Microemulsions, A. Xenakis, V. Papadimitriou, H. Stamatis, and F.N. Kolisis Microemulsions as Decontamination Media for Chemical Weapons and Toxic Industrial Chemicals, T. Hellweg, S. Wellert, H.-J. Altmann, and A. Richardt Microemulsions as Potential Interfacial Chemical Systems Applied in the Petroleum Industry, A.A.D. Neto, T.N. de Castro Dantas, M.C.P. de Alencar Moura, E.L. de Barros Neto, and A. Gurgel Nanoparticle Formation in Microemulsions: Mechanism and Monte Carlo Simulations, M. de Dios, F. Barroso, and C. Tojo Nanoparticle Uptake by (W/O) Microemulsions, M.M. Husein and N.N. Nassar TiO2 Nanoparticles in Microemulsion: Photophysical Properties and Interfacial Electron Transfer Dynamics, H.N. Ghosh Microemulsions as Pseudostationary Phases in Electrokinetic Chromatography: I. Estimation of Physicochemical Parameters. II. Analysis of Drugs in Pharmaceutical and Biofluidic Matrices, V. Tripodi and S. Lucangioli

Electrochemical investigation of interaction between mitomycin C and DNA in a novel drug-delivery system
Hakan Karadeniz, Levent Alparslan, Arzum Erdem, and Ercument Karasulu
Elsevier BV

Abdullah Levent ALPARSLAN

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