Pranshul Sethi

Hi! My name is Pranshul Sethi. I was originally born in Meerut, and now I’m an assistant professor at IIMT University, Meerut. I study the neurobiology of OCD and cellular and molecular pathways and their activators in the prevention of OCD. My interest in OCD developed during my master's From my teenage years, I was very fascinated by brain and its activity. I did my undergrad degree in pharmacy at Dr. KNMIPER, Modinagar and my master's at ISF College of Pharmacy, Moga.
Currently working on to develop the drug discovery screening procedures, establishment and validation of therapeutic moieties in, OCD, Bipolar Disease, Autism, Brain Hemorrhage, and Motor Neuron Diseases (Multiple sclerosis and Amyotrophic lateral sclerosis)
Current focusing Target: Calorie Restriction-Sirt-1, AMPK, Anti-oxidant defense mechanism, Nrf2, HO-1, Neurogenesis, Smoothened (Smo), sonic hedgehog (Shh), JAK-STAT, mTOR, PPAR-γ, IGF-1, GLP-1

EDUCATION

10th
CGPA: 9.2
Modern Senior Secondary School, Patiala (PB)

12th
Medical (Physics, Chemistry, Biology)
per: 82
Bhupindra International Public school, Patiala (PB)

B. Pharm
SGPA: 8.51
DR. KNMIPER, Modinagar (UP)

M. Pharm
Specialization: Pharmacology
SGPA: 8.53
ISF College of Pharmacy, Moga (PB)

RESEARCH INTERESTS

To understand and explore the molecular mechanisms and diagnostic markers involved in neurodegenerative and neuropsychiatric disorders (Alzheimer’s, Autism, Multiple Sclerosis, Amyotrophic lateral sclerosis, Parkinson’s, Huntington’s, Brain Hemorrhage, Obsessive Compulsive Disorder, BD)

RECENT SCHOLAR PUBLICATIONS

Stimuli-Responsive Biomaterials for Inflammatory Diseases: Advances in Research and Clinical Applications
MG Ahmed, V Subramaniyan, S Nag, S Mohanto
CRC Press , 2026
2026
Plant-Associated Medicinal Nano-Chemistry
PK Chaurasia, SL Bharati, S Singh, A Mani
CRC Press , 2026
2026
One health integration: Global perspectives on animal health and sustainable agriculture
PS Gaikwad, VH Shukla, P Choudhary
John Wiley & Sons , 2026
2026
Citations: 2
Soil Microbiome Dynamics: Exploring Interactions and Implications for Agricultural Practices
D Mitra, A Madan, W Alloun
Cambridge Scholars Publishing , 2026
2026
Molecular Mechanisms of Neurodegeneration: A Focus on Cholinergic Dysfunction and the Therapeutic Potential of Rivastigmine Derivatives
K Singh, P Sethi, D Jain, JK Gupta, Z Waqar, B Singh, R Syed, M Tabish, ...
Current Topics in Medicinal Chemistry , 2026
2026
Mechanism of Neurodegeneration in Alzheimer's Disease
P Sethi, M Bahuguna, R Saini, SN Rai, A Madan
Neurodegenerative Diseases, 36-55 , 2026
2026
Emerging Roles of Small-molecule Derivatives in Modulating Neurodegenerative Pathways: From Molecular Targets to Therapeutic Applications
K Singh, P Sethi, D Jain, JK Gupta, OA Alsaidan, SI Alzarea, A Kumar, ...
Mini-Reviews in Medicinal Chemistry , 2026
2026
Evolution and General Overview of Stimuli-Responsive Biomaterials
A Madan, R Saini, MK Satapathy, N Panwar, P Sethi, S Rastogi, U Dave
Stimuli-Responsive Biomaterials for Inflammatory Diseases, 21-43 , 2026
2026
Advances in the Synthesis of GABAergic Modulators for Anxiety and Depression: Pathways and Potential Applications
K Singh, P Sethi, D Jain, JK Gupta, OA Alsaidan, SI Alzarea, A Dubey, ...
Current Neuropharmacology , 2026
2026
Insights into the Molecular Mechanisms of Neurodegenerative Diseases: Exploring Molecular Pathways and the Therapeutic Potential of Rivastigmine
K Singh, P Sethi, M Kumari, JK Gupta, Z Waqar, D Jain, A Verma, A Bhatt, ...
CNS & Neurological Disorders-Drug Targets , 2026
2026
Nanotechnology and AI: Implications for Future of Personalized Cancer Care by Nucleic Acid Delivery
M Singh, G Arpitha, S Thomas, VJJ Jancy, SG Kala, A Singh, P Sethi
Nanotechnology for Nucleic Acid Delivery, 307-328 , 2026
2026
Herbal Nanotechnology in Detection of Health Hazardous Molecules
P Sethi, S Rastogi, N Panwar, U Dave, A Verma, A Madan
Plant-Associated Medicinal Nano-Chemistry, 251-265 , 2026
2026
Diet and Alzheimer's disease: Let food be our medicine
J Malik, SC Mandal, P Sarup, GD Lin, RW Li
Springer Nature Singapore, Imprint: Springer , 2026
2026
Citations: 1
Different Vegetables and Their Nutraceutical Significances
A Madan, P Sethi, N Panwar, S Rastogi, U Dave, A Verma
Exploration of the Medicinal Potential of Kitchen Ingredients, 1-13 , 2026
2026
Chimeric antigen receptor T-cell therapy for solid tumors: A review of the intricate mechanisms and potential strategies
S Arora, P Sethi, A Banerjee, MKM Akanda, MS Abd El Hafeez, ...
International Immunopharmacology 168, 115838 , 2026
2026
Citations: 2
Lipid-based nanostructures in targeted management of neurological disorders: a comprehensive review
M Guleria, A Kamble, M Upadhyay, P Sethi, MB Patel, A Malhan, ...
International Journal of Pharmaceutics, 126530 , 2025
2025
Citations: 2
Exploration of the Medicinal Potential of Kitchen Ingredients
PK Chaurasia, SL Bharati, S Singh, A Mani
CRC Press , 2025
2025
Citations: 1
Biotics and the Gut–Brain Axis in Neurological Disorders
N Mishra, S Ashique, M Bhowmick
CRC Press , 2025
2025
Citations: 1
Prebiotics: General Overview, Characteristics, and Application in Health Benefits
A Madan, R Kumar, P Sethi, D Mitra
Biotics and the Gut–Brain Axis in Neurological Disorders, 1-12 , 2025
2025
Emerging Global Technologies in Veterinary Sciences
BT Iber, P Sethi, R Saini, N Dhiman, A Madan
One Health Integration: Global Perspectives on Animal Health and Sustainable … , 2025
2025
Citations: 4

MOST CITED SCHOLAR PUBLICATIONS

Advances in gene therapy approaches targeting neuro-inflammation in neurodegenerative diseases
K Singh, P Sethi, S Datta, JS Chaudhary, S Kumar, D Jain, JK Gupta, ...
Ageing research reviews 98, 102321 , 2024
2024
Citations: 68
Recent review on biological barriers and host–material interfaces in precision drug delivery: advancement in biomaterial engineering for better treatment therapies
R Deshmukh, P Sethi, B Singh, J Shiekmydeen, S Salave, RJ Patel, N Ali, ...
Pharmaceutics 16 (8), 1076 , 2024
2024
Citations: 63
Nrf2/HO-1 signaling stimulation through acetyl-11-keto-beta-boswellic acid (AKBA) provides neuroprotection in ethidium bromide-induced experimental model of multiple sclerosis
S Upadhayay, S Mehan, A Prajapati, P Sethi, M Suri, A Zawawi, ...
Genes 13 (8), 1324 , 2022
2022
Citations: 62
Role of JAK-STAT and PPAR-gamma signalling modulators in the prevention of autism and neurological dysfunctions
R Khera, S Mehan, S Kumar, P Sethi, S Bhalla, A Prajapati
Molecular Neurobiology 59 (6), 3888-3912 , 2022
2022
Citations: 55
The SIRT-1/Nrf2/HO-1 axis: Guardians of neuronal health in neurological disorders
P Sethi, S Mehan, Z Khan, PK Maurya, N Kumar, A Kumar, A Tiwari, ...
Behavioural brain research 476, 115280 , 2025
2025
Citations: 45
Activation of IGF-1/GLP-1 signalling via 4-hydroxyisoleucine prevents motor neuron impairments in experimental ALS-rats exposed to methylmercury-induced neurotoxicity
A Shandilya, S Mehan, S Kumar, P Sethi, AS Narula, A Alshammari, ...
Molecules 27 (12), 3878 , 2022
2022
Citations: 43
Smo-Shh agonist Purmorphamine prevents neurobehavioral and neurochemical defects in 8-OH-DPAT-induced experimental model of obsessive-compulsive disorder
R Gupta, S Mehan, P Sethi, A Prajapati, A Alshammari, M Alharbi, ...
Brain Sciences 12 (3), 342 , 2022
2022
Citations: 43
RETRACTED: Activating SIRT-1 Signalling with the Mitochondrial-CoQ10 Activator Solanesol Improves Neurobehavioral and Neurochemical Defects in Ouabain-Induced Experimental …
B Rajkhowa, S Mehan, P Sethi, A Prajapati, M Suri, S Kumar, S Bhalla, ...
Pharmaceuticals 15 (8), 959 , 2022
2022
Citations: 33
Acetyl-11-keto-beta boswellic acid (AKBA) modulates CSTC-pathway by activating SIRT-1/Nrf2-HO-1 signalling in experimental rat model of obsessive-compulsive disorder: Evidenced …
P Sethi, S Mehan, Z Khan, S Chhabra
Neurotoxicology 98, 61-85 , 2023
2023
Citations: 31
A recent review on smart sensor-integrated wound dressings: Real-time monitoring and on-demand therapeutic delivery
M Kumar, P Sethi, J Shiekmydeen, S Rastogi, S Mahmood, S Chopra, ...
International Journal of Biological Macromolecules 313, 144251 , 2025
2025
Citations: 30
Neuroprotective action of hordenine against the Aluminium Chloride (AlCl3) induced Alzheimer's diseases & associated memory impairment in experimental rats
M Agrawal, M Singhal, BC Semwal, S Arora, B Singh, V Sikarwar, P Sethi, ...
Pharmacological Research-Modern Chinese Medicine 12, 100492 , 2024
2024
Citations: 26
Activation of SIRT-1 signalling in the prevention of bipolar disorder and related neurocomplications: target activators and influences on neurological dysfunctions
B Rajkhowa, S Mehan, P Sethi, A Prajapati
Neurotoxicity Research 40 (2), 670-686 , 2022
2022
Citations: 21
Recent advances in the synthesis of antioxidant derivatives: Pharmacological insights for neurological disorders
K Singh, JK Gupta, P Sethi, S Mathew, A Bhatt, MC Sharma, S Saha, ...
Current Topics in Medicinal Chemistry 24 (22), 1940-1959 , 2024
2024
Citations: 15
Inulin: a multifaceted ingredient in pharmaceutical sciences
R Tiwari, P Sethi, SRS Rudrangi, PK Padarthi, V Kumar, S Rudrangi, ...
Journal of Biomaterials science, Polymer edition 35 (16), 2570-2595 , 2024
2024
Citations: 14
Blockchain for Biomedical Research and Healthcare
P Kumar, A Kumari
Springer Nature , 2024
2024
Citations: 14
Emerging pharmacological approaches for Huntington's disease
K Singh, D Jain, P Sethi, JK Gupta, AK Tripathi, S Kumar, SD Sarker, ...
European Journal of Pharmacology 980, 176873 , 2024
2024
Citations: 13
Effects of malnutrition on brain development
P Sethi, A Prajapati, T Mishra, T Chaudhary, S Kumar
Nutrition and psychiatric disorders, 75-88 , 2022
2022
Citations: 13
Mechanistic insights into tau protein-mediated regulation of oxidative stress
B Pavani, G Tiwari, R Borra, S Vahora, A Vashi, RK Mukherjee
Chin. J. Appl. Physiol 40, e20240028 , 2024
2024
Citations: 12
Nutrition, neurotransmitters, and behavior
S Kumar, T Mishra, A Prajapati, P Sethi
Nutrition and psychiatric disorders, 89-108 , 2022
2022
Citations: 12
Advances in viral vector-based delivery systems for gene therapy: a comprehensive review
K Singh, D Jain, P Sethi, JK Gupta, A Dubey, A Al Noman, S Lal, ...
3 Biotech 15 (7), 196 , 2025
2025
Citations: 10

RESEARCH OUTPUTS (PATENTS, SOFTWARE, PUBLICATIONS, PRODUCTS)

Developed an equipment for OCD.
Established a drug (AKBA) for the prevention of OCD.

INDUSTRY EXPERIENCE

Research Associate: 3 months (Research Developer)
Patient Advocate: 3 months (Navya Healthcare)
Medical Scribe: 6 months (Aquity Solutions)