Genetic Polymorphisms and Predisposition to Peri-Implantitis: A Systematic Review Filomena Salazar, María Belén Alvarez, Marta Relvas, José Julio Pacheco, Marco Infante da Câmara, José Adriano Costa International Journal of Molecular Sciences, 2025 Peri-implantitis is a multifactorial inflammatory disease that can compromise the longevity of dental implants. Several studies have investigated the association between genetic variants. This systematic review aimed to assess the contribution of genetic polymorphisms to the risk of developing peri-implantitis. A systematic search was conducted in the PubMed database up to 2025 following the PICO strategy and PRISMA guidelines. Eligible studies met the following inclusion criteria: articles written in English, addressing genetic associations with peri-implantitis in human subjects, designed as clinical trials or observational (prospective or retrospective) studies, with full-text availability, and published within the last ten years. Exclusion criteria included studies in languages other than English, those not addressing the main research question, publications older than ten years, studies without full text, and secondary research such as meta-analyses or review articles. Selection and data extraction were performed independently by two reviewers. Risk of bias was evaluated qualitatively for control studies. Twenty-three studies met the inclusion criteria. Polymorphisms in genes related to inflammatory cytokines (e.g., IL-1β +3954 C/T, IL-10, TNF-α), bone metabolism (OPG, BMP4, FGF10), and immune regulation (CD14 rs2569190, miR-27a-3p) were frequently reported. IL-1β +3954 C/T, ET-1 and IL-1β, MMP-8 rs11225395 (T allele), MMP8 (−799 C/T), and CD14 rs2569190 showed consistent associations with increased peri-implantitis risk, while the results for TNF-α −308 G/A were inconsistent across populations. These findings suggest a potential role of genetic predisposition in peri-implantitis development. Identifying genetic biomarkers may help predict susceptibility and personalize management strategies.
Effectiveness of Photobiostimulation and Ablation With Diode Laser in Oral Squamous Papilloma: A Case Report J. A. Costa, M. B. Alvarez, L. Monteiro, P. Rompante, F. Salazar, M. Relvas, M. I. Câmara Case Reports in Dentistry, 2025 This study evaluates the therapeutic effectiveness of diode laser and photobiostimulation (PBS) in the treatment of an oral squamous papilloma in the lingual mucosa in a 69‐year‐old male. The patient was subjected to complete hematological examination, and all parameters were within normal limits. The kind of damage, accessibility, aesthetics, and possibility of bleeding all played a role in the choice of therapy. The lesion was totally excised using the diode laser, and PBS was applied to contribute to healing and reduction of bleeding and inflammation. The patient had no pain throughout this process, which was shown to be a fast and efficient method of therapy. After 30 days, the lesion was fully healed, and 1 year of follow‐up has been completed positively with no recurrences. In conclusion, PBS promoted rapid healing and diode laser is an alternative in these types of oral lesions and a good substitute for traditional surgery.
Osseodensification vs. Conventional Osteotomy: A Case Series with Cone Beam Computed Tomography José Adriano Costa, José Manuel Mendes, Filomena Salazar, José Júlio Pacheco, Paulo Rompante, Joaquim Ferreira Moreira, José Diogo Mesquita, Nuno Adubeiro, Marco Infante da Câmara Journal of Clinical Medicine, 2024 Introduction: Osseodensification is a non-extraction technique using specially designed drills to increase bone density while extending an osteotomy, allowing bone to be preserved and condensed by compacting autograft during osteotomy preparation, increasing bone density around implants, and improving mechanical stability. Aim: The objective of this study is to compare conventional osteotomy and osseodensification protocols in implant placement and analyze whether there are differences in bone density. Materials and Methods: Study variables were defined, namely, osseodensification technique, conventional osteotomy technique, bone density, sex, area of location, implant dimensions, implant dimensions, and implant stability. Eligibility and exclusion criteria were defined. A step-by-step surgical protocol was developed. The surgeon and radiologist underwent intra-examiner calibration. A total of 15 patients were selected according to the eligibility criteria, and a total of 41 implants were inserted, 20 implants by conventional osteotomy and 21 by osseodensification. A cone beam computed tomography was performed one year after prosthetic rehabilitation to estimate bone density. Data were collected and recorded, and in the analysis of the association of variables, non-parametric tests were applied. Results: Significant statistical results were found in bone density values, with higher values being obtained with the osseodensification technique, that is, median density values of 1020, and median density values of 732 for the bone drilling technique. The results of the correlation between bone density in both techniques and sex, primary implant stability, implant dimensions and location area were statistically non-significant. Conclusions: Within the limitations of this study, there are differences in bone density between conventional osteotomy and osseodensification protocols. Bone density is increased with osseodensification over a study period of one year.
Analysis of peri-implant bone defects by using cone beam computed tomography (CBCT): an integrative review J. A. Costa, J. M. Mendes, F. Salazar, J. J. Pacheco, P. Rompante, M. I. Câmara Oral Radiology, 2023 The objective of this work was to perform an integrative review of the inspection of peri-implant bone defects using cone beam computed tomography (CBCT). An electronic search was performed in the PubMed database using the following scientific terms: CBCT or Cone Beam computed tomography; dental implant; peri-implant; bone loss; defects. The survey identified 267 studies, of which 18 were considered relevant to this study. These studies provided important data taking into account the accuracy of cone beam computed tomography in the detection and measurement of peri-implant bone defects such as fenestrations, dehiscence and intraosseous circumferential defects. The effectiveness of CBCT in aiding in geometric bone calculations and in the diagnosis of peri-implant defects was influenced by factors such as artefacts, defect size, bone wall thickness, implant material, adjustment of acquisition parameters and observer experience. A not insignificant number of studies compared intraoral radiography to CBCT in the detection of peri-implant bone loss. CBCT was clearly superior to intraoral radiography in the detection of all peri-implant bone defects, except for defects located in the interproximal zone. In general, studies have shown that peri-implant bone measurements adjacent to the implant surface can be correctly determined, as well as the diagnosis of peri-implant bone defects with an average discrepancy of less than 1 mm from the actual measurement of the defect.
Aesthetic depigmentation of gingival smoker's melanosis using carbon dioxide lasers Luis Silva Monteiro, José Adriano Costa, Marco Infante da Câmara, Rui Albuquerque, Marco Martins, José Júlio Pacheco, Filomena Salazar, Fernando Figueira Case Reports in Dentistry, 2015 Melanic pigmentation results from melanin produced by the melanocytes present in the basal layer of the oral epithelium. One of the most common causes of oral pigmentation is smoker melanosis, a condition associated with the melanocyte stimulation caused by cigarette smoke. This paper aims to illustrate the use of a carbon dioxide laser in the removal of the gingival melanic pigmentation for aesthetic reasons in a 27-year-old female patient with history of a smoking habit. The carbon dioxide laser vaporisation was performed on the gingival mucosa with effective and quick results and without any complications or significant symptoms after the treatment. We conclude that a carbon dioxide laser could be a useful, effective, and safe instrument to treat the aesthetic complications caused by oral smoker melanosis.
RECENT SCHOLAR PUBLICATIONS
Genetic Polymorphisms and Predisposition to Peri-Implantitis: A Systematic Review F Salazar, MB Alvarez, M Relvas, JJ Pacheco, MI Câmara, JA Costa International Journal of Molecular Sciences 26 (23), 11461 , 2025 2025 Citations: 1
Effectiveness of Photobiostimulation and Ablation With Diode Laser in Oral Squamous Papilloma: A Case Report JA Costa, MB Alvarez, L Monteiro, P Rompante, F Salazar, M Relvas, ... Case Reports in Dentistry 2025 (1), 6293919 , 2025 2025
Osseodensification vs. conventional osteotomy: A case series with cone beam computed tomography JA Costa, JM Mendes, F Salazar, JJ Pacheco, P Rompante, JF Moreira, ... Journal of Clinical Medicine 13 (6), 1568 , 2024 2024 Citations: 15
Analysis of peri-implant bone defects by using cone beam computed tomography (CBCT): an integrative review JA Costa, JM Mendes, F Salazar, JJ Pacheco, P Rompante, MI Câmara Oral Radiology, 1-12 , 2023 2023 Citations: 35
APLICAÇÃO DE HIDROLISADO PROTEICO DE Spirulina EM GELATINA AM Pereira, TD Santos, JAV Costa Universidade Federal Do Rio Grande 53, 1-6 , 2020 2020 Citations: 1
Frequência do consumo de alimentos in natura ou minimamente processados em lactentes GD Santos, JA Costa, M Pereira Netto HU rev 43 (3), 233-8 , 2017 2017 Citations: 4
Prevalence of arterial hypertension and diabetes mellitus in carriers of chronic kidney disease in treatment conservator of the ubaense nefrologia service FC Soares, IA Aguiar, NPF Carvalho, RF Carvalho, RA Torres, ... Revista Cientifica Fagoc Saúde [Internet] 2 (2), 21-26 , 2017 2017 Citations: 7
Case Report Aesthetic Depigmentation of Gingival Smoker’s Melanosis Using Carbon Dioxide Lasers LS Monteiro, JA Costa, MI da Câmara, R Albuquerque, M Martins, ... Hindawi Publishing Corp 1, 1-3 , 2015 2015 Citations: 2
Compartimentação Fisiográfica do Estado de São Paulo: base para análises ambientais em escala regional R Vedovello, CJ Ferreira, A Salim, JA COSTA, K Matsuzaki, ... SIMPÓSIO BRASILEIRO DE CARTOGRAFIA GEOTÉCNICA E GEOAMBIENTAL 9 , 2015 2015 Citations: 3
C-FICOCIANINA INCORPORADA À NANOFIBRAS: DETERMINAÇÃO DE TERMOESTABILIDADE ARC BRAGA, FS FIGUEIRA, JT SILVEIRA, PBM SILVA, MG MORAIS, ... Blucher Chemical Engineering Proceedings 1 (2), 2489-2494 , 2015 2015
Aesthetic depigmentation of gingival smoker’s melanosis using carbon dioxide lasers LS Monteiro, JA Costa, MI da Câmara, R Albuquerque, M Martins, ... Case reports in dentistry 2015 (1), 510589 , 2015 2015 Citations: 28
Guia para a extração de sangue de grado (Croton lechleri Müll. Arg.): recomendações técnicas para a extração de látex de sangue de grado (sangue de dragão) K AZEVEDO, A ALECHANDRE, A Lima, A Leite, T Melo, J Costa, ... Rio Branco-AC: USAID/IPAM , 2008 2008 Citations: 11
Phycocyanin extraction from different biomasses of Spirulina sp. CC Moraes, JFM Burket, JAV Costa, SJ Kalil 2007 Citations: 1
Economic and emergy analysis in integrated system of irrigated rice production in transition to organic cultivation. GG Teixeira, RV Carvalho, JAV Costa 2007
Fermentados acético piloto; projeto, construção e operação EM Perret, JAV Costa Salão de Iniciação Científica (03.: 1991: Porto Alegre, RS). Livro de … , 1991 1991
Obtenção de xarope de glicose a partir de hidrólise ácida do amido de arroz CRS Moraes, JAV Costa, MS Mellado Salão de Iniciação Científica (03.: 1991: Porto Alegre, RS). Livro de … , 1991 1991
MOST CITED SCHOLAR PUBLICATIONS
Analysis of peri-implant bone defects by using cone beam computed tomography (CBCT): an integrative review JA Costa, JM Mendes, F Salazar, JJ Pacheco, P Rompante, MI Câmara Oral Radiology, 1-12 , 2023 2023 Citations: 35
Aesthetic depigmentation of gingival smoker’s melanosis using carbon dioxide lasers LS Monteiro, JA Costa, MI da Câmara, R Albuquerque, M Martins, ... Case reports in dentistry 2015 (1), 510589 , 2015 2015 Citations: 28
Osseodensification vs. conventional osteotomy: A case series with cone beam computed tomography JA Costa, JM Mendes, F Salazar, JJ Pacheco, P Rompante, JF Moreira, ... Journal of Clinical Medicine 13 (6), 1568 , 2024 2024 Citations: 15
Guia para a extração de sangue de grado (Croton lechleri Müll. Arg.): recomendações técnicas para a extração de látex de sangue de grado (sangue de dragão) K AZEVEDO, A ALECHANDRE, A Lima, A Leite, T Melo, J Costa, ... Rio Branco-AC: USAID/IPAM , 2008 2008 Citations: 11
Prevalence of arterial hypertension and diabetes mellitus in carriers of chronic kidney disease in treatment conservator of the ubaense nefrologia service FC Soares, IA Aguiar, NPF Carvalho, RF Carvalho, RA Torres, ... Revista Cientifica Fagoc Saúde [Internet] 2 (2), 21-26 , 2017 2017 Citations: 7
Frequência do consumo de alimentos in natura ou minimamente processados em lactentes GD Santos, JA Costa, M Pereira Netto HU rev 43 (3), 233-8 , 2017 2017 Citations: 4
Compartimentação Fisiográfica do Estado de São Paulo: base para análises ambientais em escala regional R Vedovello, CJ Ferreira, A Salim, JA COSTA, K Matsuzaki, ... SIMPÓSIO BRASILEIRO DE CARTOGRAFIA GEOTÉCNICA E GEOAMBIENTAL 9 , 2015 2015 Citations: 3
Case Report Aesthetic Depigmentation of Gingival Smoker’s Melanosis Using Carbon Dioxide Lasers LS Monteiro, JA Costa, MI da Câmara, R Albuquerque, M Martins, ... Hindawi Publishing Corp 1, 1-3 , 2015 2015 Citations: 2
Genetic Polymorphisms and Predisposition to Peri-Implantitis: A Systematic Review F Salazar, MB Alvarez, M Relvas, JJ Pacheco, MI Câmara, JA Costa International Journal of Molecular Sciences 26 (23), 11461 , 2025 2025 Citations: 1
APLICAÇÃO DE HIDROLISADO PROTEICO DE Spirulina EM GELATINA AM Pereira, TD Santos, JAV Costa Universidade Federal Do Rio Grande 53, 1-6 , 2020 2020 Citations: 1
Phycocyanin extraction from different biomasses of Spirulina sp. CC Moraes, JFM Burket, JAV Costa, SJ Kalil 2007 Citations: 1
Effectiveness of Photobiostimulation and Ablation With Diode Laser in Oral Squamous Papilloma: A Case Report JA Costa, MB Alvarez, L Monteiro, P Rompante, F Salazar, M Relvas, ... Case Reports in Dentistry 2025 (1), 6293919 , 2025 2025
C-FICOCIANINA INCORPORADA À NANOFIBRAS: DETERMINAÇÃO DE TERMOESTABILIDADE ARC BRAGA, FS FIGUEIRA, JT SILVEIRA, PBM SILVA, MG MORAIS, ... Blucher Chemical Engineering Proceedings 1 (2), 2489-2494 , 2015 2015
Economic and emergy analysis in integrated system of irrigated rice production in transition to organic cultivation. GG Teixeira, RV Carvalho, JAV Costa 2007
Fermentados acético piloto; projeto, construção e operação EM Perret, JAV Costa Salão de Iniciação Científica (03.: 1991: Porto Alegre, RS). Livro de … , 1991 1991
Obtenção de xarope de glicose a partir de hidrólise ácida do amido de arroz CRS Moraes, JAV Costa, MS Mellado Salão de Iniciação Científica (03.: 1991: Porto Alegre, RS). Livro de … , 1991 1991