Cancer Modeling
Agriculture insects modeling
Computational Biology
1
Scopus Publications
12
Scholar Citations
2
Scholar h-index
Scopus Publications
Are more complicated tumour control probability models better? J. Gong, M. M. Dos Santos, C. Finlay, T. Hillen Mathematical Medicine and Biology, 2013 Mathematical models for the tumour control probability (TCP) are used to estimate the expected success of radiation treatment protocols of cancer. There are several TCP models in the literature, from the simplest (Poissonian TCP) to the well-advanced stochastic birth-death processes. Simple and complex models often make the same predictions. Hence, here, we present a systematic study where we compare six of these TCP models: the Poisson TCP, the Zaider-Minerbo TCP, a Monte Carlo TCP and their corresponding cell cycle (two-compartment) models. Several clinical non-uniform treatment protocols for prostate cancer are employed to evaluate these models. These include fractionated external beam radiotherapies, and high and low dose rate brachytherapies. We find that in realistic treatment scenarios, all one-compartment models and all two-compartment models give basically the same results. A difference occurs between one-compartment and two-compartment models due to reduced radiosensitivity of quiescent cells.We find that care must be taken for the right choice of parameters, such as the radiosensitivities α and β and the hazard function h. Typically, different hazard functions are used for fractionated treatment (fractionated survival fraction) and for brachytherapies (Lea-Catcheside protraction factor). We were able to combine these two approaches into one 'effective' hazard function. Based on our results, we can recommend the use of the Poissonian TCP for everyday treatment planning. More complicated models should only be used when absolutely necessary.
RECENT SCHOLAR PUBLICATIONS
CONSTRUÇÃO DE UM GUIA INFORMATIVO SOBRE BENEFÍCIOS DO GOVERNO BRASILEIRO PARA POPULAÇÕES ESPECÍFICAS G da Silveira Santos, TMS Santos, MM dos Santos, CC da Silva Barros, ... Revista Políticas Públicas & Cidades 14 (1), e1618-e1618 , 2025 2025
Analysis of tissue-equivalent materials using the Monte Carlo simulation code PENELOPE FFM Santos, TA Pianoschi, MM Santos Proceedings of the 27. Brazilian congress on medical physics, 87-87 , 2023 2023
Effects of radiobiological parameters on TCP for breast radiotherapy LN Furlan, TA Pianoschi, MM Santos Proceedings of the 27. Brazilian congress on medical physics, 190-190 , 2023 2023
Evaluation of TCP with different radiosen-sitivities for prostate cancer GM Pereira, MM Santos, TA Pianoschi Brazilian Journal of Oncology 17 (continuous publication), 101328 , 2021 2021
PROJETO INTEGRADOR: ANáLISE DE UmA EXPERIêNCIA NO IF GOIANO CAMPUSCERES AH Braga¹, EAM Monteiro, MM dos Santos, FB da Cunha⁴ ENSINO MÉDIO INTEGRADO NO BRASIL: FUNDAMENTOS, PRÁTICAS E DESAFIOS, 216 , 2017 2017 Citations: 8
Probabilidade de controle tumoral: modelos e estatísticas MM Santos Universidade de São Paulo , 2014 2014
ROC analysis in radiotherapy: a TCP model-based test M Santos, U Neves Open J Appl Sci 3 (2), 186-193 , 2013 2013 Citations: 3
A proposal for evaluating the prediction capacity of TCP model MM Santos, UPC Neves Book of Abstracts , 2011 2011
SU‐FF‐I‐71: Study of a Well‐Type Ionization Chamber by Monte Carlo Simulation M Santos, F Takeda, T Pianoschi, P Nicolucci Medical Physics 36 (6Part4), 2450-2451 , 2009 2009
SU‐FF‐T‐282: Development of a Multi Electrode Well Ionization Chamber to Be Used in Nuclear Medicine F Takeda, M Santos, J Vieria, W Calvo, TG Netto, P Nicolucci Medical Physics 36 (6Part13), 2586-2586 , 2009 2009
Urinary System in Vibroacoustic Disease-Current Findings and Ongoing Studies M dos Santos, JA Sousa, MC Marques, E Monteiro, M Alves-Pereira, ... Proceedings of the 12th International Congress of Sound and Vibration , 2005 2005 Citations: 1
Estudo de uma câmara de ionização tipo poço através de simulação Monte Carlo M Santos 2000
MOST CITED SCHOLAR PUBLICATIONS
PROJETO INTEGRADOR: ANáLISE DE UmA EXPERIêNCIA NO IF GOIANO CAMPUSCERES AH Braga¹, EAM Monteiro, MM dos Santos, FB da Cunha⁴ ENSINO MÉDIO INTEGRADO NO BRASIL: FUNDAMENTOS, PRÁTICAS E DESAFIOS, 216 , 2017 2017 Citations: 8
ROC analysis in radiotherapy: a TCP model-based test M Santos, U Neves Open J Appl Sci 3 (2), 186-193 , 2013 2013 Citations: 3
Urinary System in Vibroacoustic Disease-Current Findings and Ongoing Studies M dos Santos, JA Sousa, MC Marques, E Monteiro, M Alves-Pereira, ... Proceedings of the 12th International Congress of Sound and Vibration , 2005 2005 Citations: 1
CONSTRUÇÃO DE UM GUIA INFORMATIVO SOBRE BENEFÍCIOS DO GOVERNO BRASILEIRO PARA POPULAÇÕES ESPECÍFICAS G da Silveira Santos, TMS Santos, MM dos Santos, CC da Silva Barros, ... Revista Políticas Públicas & Cidades 14 (1), e1618-e1618 , 2025 2025
Analysis of tissue-equivalent materials using the Monte Carlo simulation code PENELOPE FFM Santos, TA Pianoschi, MM Santos Proceedings of the 27. Brazilian congress on medical physics, 87-87 , 2023 2023
Effects of radiobiological parameters on TCP for breast radiotherapy LN Furlan, TA Pianoschi, MM Santos Proceedings of the 27. Brazilian congress on medical physics, 190-190 , 2023 2023
Evaluation of TCP with different radiosen-sitivities for prostate cancer GM Pereira, MM Santos, TA Pianoschi Brazilian Journal of Oncology 17 (continuous publication), 101328 , 2021 2021
Probabilidade de controle tumoral: modelos e estatísticas MM Santos Universidade de São Paulo , 2014 2014
A proposal for evaluating the prediction capacity of TCP model MM Santos, UPC Neves Book of Abstracts , 2011 2011
SU‐FF‐I‐71: Study of a Well‐Type Ionization Chamber by Monte Carlo Simulation M Santos, F Takeda, T Pianoschi, P Nicolucci Medical Physics 36 (6Part4), 2450-2451 , 2009 2009
SU‐FF‐T‐282: Development of a Multi Electrode Well Ionization Chamber to Be Used in Nuclear Medicine F Takeda, M Santos, J Vieria, W Calvo, TG Netto, P Nicolucci Medical Physics 36 (6Part13), 2586-2586 , 2009 2009
Estudo de uma câmara de ionização tipo poço através de simulação Monte Carlo M Santos 2000
