Dr Iheanyi Omezuruike Okonko

@uniport.edu.ng

Teaching & Research Virologist, Immunologist & Molecular Epidemiologist (Genomics), Virus & Genomics Research Unit, Department of Microbiology, Faculty of Science
University of Port Harcourt, Nigeria

Dr Iheanyi Omezuruike Okonko


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Presently, I am a Senior Lecturer (Teaching & Research Medical Virologist, Immunologist and Molecular Epidemiologist in the Virus Research Unit of the Department of Microbiology, University of Port Harcourt, Nigeria. I specialized in Medical Virology, Immunology, Vaccinology and Molecular Epidemiology. I have 11 active years as a Teaching and Research Virologist in University of Port Harcourt, Nigeria. I have demonstrated over the recent years my strong impact on Virology research and education through my array of publications and my involvement in teaching of trainees from our resource-limited settings. My primary areas of interest are studies on HIV-1 Genetic Diversity, Viral diversities and evolutions, HIV-1 P24 antigens, coinfections, drug resistance and tropism, all of which are highly understudied in Nigeria. I have successfully supervised several BSc projects, 16 MSc Dissertations, 5 Ph.D. Theses in Virology and currently supervising 16 PhD Theses in Virology.

EDUCATION

Ebonyi State University, Abakaliki, Nigeria Ph.D. in Virology 2017
American Association of Immunology (AAI), Boston, United States Certificate in Advanced Immunology 2015
West African Bioethics Training Program (WABTP) in collaboration with Collaborative Institutional Training Initiative (CITI), University of Miami, Florida, USA Certificate in Nigerian National Code for Health Research Ethics (NNCHRE) Stage I Course 2012
Triune Biblical University, Brooklyn, United States Ph.D. in Christian Education 2011
Triune Biblical University, Brooklyn, United States Masters in Christian Education 2008
West African Bioethics Training Centre (WABTC) In Collaboration with University of Miami, Florida, United States Certificate in Ethics (Human-Subject Protection) 2008
University of Ibadan, Ibadan, Nigeria M.Sc. in Virology 2007
University of Ibadan in Collaboration with Institute of Immunology, Luxembourg Certificate in Immunology 2005

RESEARCH INTERESTS

HIV-1 Genetic Diversity, Viral diversities and evolutions, HIV-1 P24 antigens, coinfections, drug resistance and tropism
Global emergence of recombinant HIV and its impact on vaccine design
Longitudinal multi-cohort study to compare the global emergence of HIV Non-clade B drug resistance mutations

FUTURE PROJECTS

Unravelling the genetic diversity of HIV-1 sequences markers that are associated with disease parameters in HIV-1 positive individuals in Nigeria.

Our goal here is to obtain sequence patterns that are associated with strong immune responses and beneficial clinical outcome.


Applications Invited
Collaborators

“SARS-CoV-2 viral adaptations and antiviral immune responses in global COVID-19 infection”

We analyze longitudinal SARS-CoV-2 sequences, serologic responses (multiplex binding assay, IgG/IgM/IgA subtyping, cell-based Spike binding, cytokine profiles, transcriptomics, and neutralizing anti-SARS-CoV-2 antibodies using single B cell isolations and antibody deep sequencing including structural characterization.


Applications Invited
Collaborators

“Global emergence of recombinant HIV and its impact on vaccine design”. A related emphasis is on the “Longitudinal multi-cohort study to compare the global emergence of HIV Non-clade B drug resis

This project is about emerging HIV drug resistance in key global regions. . I am also working on HIV-1 diversity using plasma, which is mostly from Nigerian HIV+ individuals. We are examining HIV-1 viral recombination and the impact on the humoral immune responses. This includes analyses of HIV sequences from the envelope and the polymerase genomic region that are essential for HIV entry and replication. These researches are critical to extending knowledge on HIV/AIDS prevention activities and vaccine trials in West Africa.


Applications Invited
Collaborators
70

Scopus Publications

6973

Scholar Citations

44

Scholar h-index

161

Scholar i10-index

Scopus Publications

  • Multidrug-Resistant and Extremely Drug-Resistant Pseudomonas aeruginosa in Clinical Samples From a Tertiary Healthcare Facility in Nigeria
    Amaka Marian AWANYE, Chidozie Ngozi IBEZIM, Catherine Nonyelum STANLEY, Hannah ONAH, Iheanyi Omezurike OKONKO, et al.
    Turkish Journal of Pharmaceutical Sciences, 2022
    Objectives Pseudomonas aeruginosa has been globally implicated in healthcare-associated infection. The susceptibility pattern of clinical isolates of P. aeruginosa to anti-pseudomonal antibiotics is reported. Materials and Methods Clinical samples, namely blood, urine, tracheal aspirate, cerebrospinal fluid (CSF), wound swabs, high vaginal swabs, eye, and ear exudates were obtained from patients, processed and identified using standard microbiological protocols. Antibiotic susceptibility testing was undertaken using the Kirby Bauer Disc diffusion method. Results were reported following the Clinical and Laboratory Standards Institute guidelines. Results Of 104 P. aeruginosa isolates identified, males (52.88%) had a higher incidence of infection than female (47.11%) patients. The highest prevalence was recorded from wound swabs [46 (44.23%)] followed by ear exudates [23 (22.12%)], urine [22 (21.15%)], while eye exudates and samples from the CSF yielded the least [1 (0.96% each)]. From the antibiogram, imipenem had the highest antibiotic activity (91.3%) followed by polymyxin B (84.6%). The isolates exhibited the highest resistance to ceftazidime (73.1%) and piperacillin-tazobactam (61.5%). The antibiotic susceptibility pattern of P. aeruginosa isolates revealed 7.69% susceptible, 26% resistant, 61% multidrug resistance (MDR), 5% extremely drug resistance (XDR), and an absence (0%) of pandrug-resistant phenotypes. Conclusion The study recorded alarmingly high cases of MDR and some XDR phenotypes of P. aeruginosa in University of Port Harcourt Teaching Hospital. It will help identify existing gaps in antimicrobial resistance surveillance and assist in improving public health policies regarding antibiotic stewardship, initiatives, and interventions.
  • Potential public health risks associated with suya spice mix in Port Harcourt, Nigeria
    Ngozi N. Odu, Best Akwasiam, Anwuli U. Osadebe, Iheanyi O. Okonko
    Toxicology and Environmental Health Sciences, 2020
  • HIV coinfections with tuberculosis among HIV-1 infected individuals in old cross river state, Nigeria
    Iheanyi Omezuruike Okonko, Immaculate Ugochi Ejike, Chioma Innocent-Adiele, Tochi Ifeoma Cookey
    Journal of Immunoassay and Immunochemistry, 2020
    Human immunodeficiency virus (HIV) and Tuberculosis (TB) are two main global public health threats that dent development in low and middle-income countries. This study evaluated the HIV/TB co-infection rate among HIV-1 infected individuals in old Cross River State, Nigeria. A total of 417 HIV-infected individuals participated in this study, 241 (57.8%) from Calabar, Cross River State, Nigeria and 176 (42.2%) from Uyo, Akwa-Ibom State, Nigeria. The age range of the 417 HIV-1 positive individuals who participated in the study was 4–72 years with an average age of 39.1 years. Plasma samples were analyzed for HIV and TB using fourth-generation Enzyme-Linked immunosorbent Assay. The CD4 count was enumerated using the Partec CyFlow® Counter. Plasma viral loads (PVL) were determined using the Abbott Real-Time HIV-1 assay. Results showed that 230 (55.2%) of the participants were in the 31–45 years age range. The majority (67.4%) of the HIV-1 infected individuals were females and 32.6% were males. An overall prevalence of HIV/TB coinfection in Old Cross River State, Nigeria was 1.4%, with Akwa Ibom State (0.6%) and Cross River State (1.2%). A higher prevalence of HIV/TB coinfection was observed among females (1.8%) than in males (0.7%). Higher prevalences of HIV/TB coinfections was observed in patients above 45 years of age (2.2%), married (2.3%), tertiary education (1.8%) followed by those with secondary education (1.4%), traders and civil servants (3.1%), patients with CD4 counts 200–349 and ≥500 cells/μl (1.9%), and those with viral load <40 copies/mL (2.7%). This study confirmed the presence of HIV/TB co-infection in old Cross River State, Nigeria. Although the prevalence rate of HIV/TB coinfection was low, its presence alone among HIV-1 infected individuals makes it a major source of concern. This finding highlights the need for a well-structured approach to the management of co-infection, and this includes both the social and medical aspects of the problem.
  • Prevalence of Candida spp. and age-related disparities amongst women presenting with vaginitis at the obstetrics and gynaecology (O&G) clinic in a tertiary hospital in Port Harcourt, Nigeria
    Chiaka Mbakwem-Aniebo, Anwuli Uche Osadebe, Eunice Athanasonny, Iheanyi Omezurike Okonko
    African Health Sciences, 2020
    Background: Vaginitis, an infection of the lower genital tract in women, is known to be triggered by the overgrowth of the vagina’s naturally occurring microorganisms.&#x0D; Objective: This study looked at the prevalence of Candida spp. and age-related disparities amongst women presenting with vag- initis at the Obstetrics and Gynaecology (O&amp;G) clinic in a tertiary hospital in Port Harcourt, Nigeria.&#x0D; Methods: One hundred high vaginal swabs were collected from pregnant and non-pregnant women and examined microscop- ically and microbiologically.&#x0D; Results: Age-group 20–29 years had the highest incidence of candidal vaginitis. There was a higher occurrence of yeast cells in pregnant than in non-pregnant participants while the non-pregnant women had a greater level of bacterial cells. Forty (40) of the samples contained yeasts of Candida species representing a 40% prevalence. Three species of Candida were identified with C. albicans dominating. Of the 40 samples positive for Candida spp., 30 (75.0%) were confirmed to be C. albicans. The remaining isolates were C. tropicalis (15.0%) and C. parapsilosis (10.0%).&#x0D; Conclusion: The findings in this study would play a role in the future management of Candida-induced vaginitis.&#x0D; Keywords: Candida; epidemiology; prevalence; vaginitis; vulvovaginal candidiasis.
  • Determination of antibodies to human immunodeficiency virus type 1&2&O and P24–antigen in pregnant women in port harcourt Nigeria
    Iheanyi Omezuruike Okonko, Eberechukwu Maryann Okoli
    Journal of Immunoassay and Immunochemistry, 2020
    The need for a cure against HIV infection and a need to improve HIV screening amongst low risk population such as pregnant women have been an issue since the emergence of HIV. Therefore, a hospital-based cross-sectional study was adopted to determine the prevalence of antibodies to HIV-1/2/O and P24 antigen among pregnant women in Port Harcourt, Nigeria. Estimating the HIV seropositivity in pregnant women will offer vital information for monitoring the trend of HIV infection in the general population and assist in prevention from mother-to-child transmission. The occurrence of antibodies to HIV type 1/2/O and P24 antigen among the pregnant women was investigated using fourth-generation ELISA. The influence of the women’s age, marital status, occupation, educational status and gestation period on the prevalence of these antibodies against HIV type 1/2/O and P24 antigen was also considered. Of the 86 pregnant women, 14 were found to be HIV-positive with seropositivity rate of 32.6%. Majority of HIV seropositive women (41.2%) were in the age group of 31–42 years. Higher seropositivity was observed among singles (50.0%), those with secondary education (44.7%), unemployed (47.8%) and in those in their third trimester (40.0%). Additionally, this study observed high seropositivity of antibodies to HIV type 1, 2, O and P24 antigen among pregnant women in Port Harcourt, Nigeria and calls for urgent and concerted efforts aimed at promoting behavioral and socio-cultural practices that could change the current high rate of HIV seropositivity amongst pregnant women in Nigeria. A combination of preventive strategies such as the use of condoms, breaking the chain of transmission within sexual networks by prompt treatment and reducing the amount of unsafe sexual behavior, promoting sexual abstinence and behavioral change from high-risk behavior are advocated.
  • Immunological and epidemiological evaluation of EBV infections among HIV-1 infected individuals in Abakaliki, Nigeria supports the potential use of neutrophils as a marker of EBV in HIV disease progression and as useful markers of immune activation
    Iheanyi Omezuruike Okonko, Taiwo Salami Makinde, Blessing Jachinma Okonko, Ogbonnaya Ogbu
    Journal of Immunoassay and Immunochemistry, 2020
    Human herpesvirus 4 which is commonly known as Epstein-Barr virus (EBV) is one of the opportunistic pathogens that affect human immunodeficiency virus (HIV) infected individuals and it is the leading cause of death and cancer in humans. The study was designed to evaluate the prevalence of EBV among HIV-1 infected individuals in Abakaliki metropolis, Ebonyi State, Nigeria. A total of 91 HIV-1 infected individuals were collected from Mile 4 Hospital, Abakaliki, Ebonyi State, Nigeria. ELISA was used to determine the Epstein-Barr Nuclear Antigen (EBNA) IgG and IgM antibodies. Full blood count (FBC), white cell count (WBC) and differential counts were also determined using standard hematological methods. Of the 91 serum samples obtained from HIV-1 infected individuals, 87(95.6%) and 20(22.0%) samples were found to be positive for EBVNA IgG and IgM antibody respectively. All the age groups had significant IgG prevalence, but age groups ≤ 20 years, and ≥ 41 had the highest prevalence while age group 21–30 years was found to have a less rate of prevalence. Also, the highest seropositivity for IgM antibodies was observed in the age group 31–40 years (32.4%) while the age groups ≤20 years (0.0%) is the lowest. However, these differences were not statistically associated with PVL and EBVNA IgG (p = .4311) and IgM antibodies (p = .4861).Higher seropositivity of EBVNA IgG occurred among those with PVL 41–10,000 copies/mL (100.0%) and PVL 10,001 copies/mL and above (100.0%) compared to those with PVL less than or equal to 40 copies/mL (95.0%). While regarding EBVNA IgM antibodies, higher seropositivity of EBVNA IgM occurred among those with PVL less than or equal to 40 copies/mL (25.0%) compared to those with PVL 41–10,000 copies/mL (20.0%) and PVL 10,001 copies/mL and above (8.3%). There was a significant difference in Neutrophils p < .026 between the mean of females and males (40.9 ± 11.7 and 36 ± 31.1) infected with EBV IgM in HIV individuals. There was also a significant positive correlation between CD4 counts and the WBC, Lymphocytes, Eosinophils and the neutrophil among the HIV-1 individuals used for this study. The correlations observed between both CD4+ count and neutrophil support the potential use of neutrophils as a marker of EBV in HIV disease progression and as useful markers of immune activation.
  • Near full genome characterization of HIV-1 unique recombinant forms in Cameroon reveals dominant CRF02_AG and F2 recombination patterns
    Andrew N Banin, Michael Tuen, Jude S Bimela, Marcel Tongo, Paul Zappile, et al.
    Journal of the International AIDS Society, 2019
    In Cameroon, a manifold diversity of HIV strains exists with CRF02_AG and unique recombinant forms (URFs) being the predominant strains. In recent years, a steady increase in URFs and clade F2 viruses has been monitored through partial genome sequencing. There is an information gap in the characterization of emerging URFs along the full genome, which is needed to address the challenges URFs pose towards diagnosis, treatment and HIV‐1 vaccine design.
  • HIV and tuberculosis co-infection in a highly HIV-infected population of rivers state, Nigeria
    Iheanyi O. Okonko, Amaoge Anyanwu, Anwuli U. Osadebe, Ngozi N. Odu
    Journal of Immunoassay and Immunochemistry, 2018
    Human Immunodeficiency Virus (HIV) and tuberculosis (TB) are considered as key players in the global health scene. This study sought to determine the prevalence of TB among HIV-positive attendees of the Directly Observed Treatment of Short Course (DOTS) program at the military hospital in Port Harcourt. The association of HIV prevalence with gender and age as risk factors was also determined. A total of 200 patients aged 15–65 years were screened. Re-screening for HIV was done for confirmation. The overall prevalence for anti-TB antibodies amongst HIV-positive individuals was 14.0% (7.5% in males and 6.5% in females) while HIV prevalence following re-screening was 92%. It was observed that based on employment status and level of education, the highest HIV prevalence was seen in unemployed individuals and individuals with no formal education. The result showed that 29.9% of the HIV seropositives were males while 70.1% were females. Sex-related prevalence of HIV–TB coinfection within groups indicated significantly higher co-infection rates (P < 0.05) among males (23.1%) than females (9.6%). Age-related prevalence of HIV–TB coinfection within groups showed that co-infection was significantly greater (P < 0.05) in ages below 30 years (21.2%) than in their counterparts 30 years and above (9.6%). This study confirmed the presence of TB co-infections among HIV-positive individuals in Port Harcourt, Nigeria. Considering the role of TB in driving the HIV pandemic, it is imperative that HIV-positive patients are screened for TB infection regularly to reduce the scale of active HIV–TB co-infection.
  • Prevalence of cytomegalovirus IgG antibodies among pregnant women visiting antenatal clinic, LAUTECH Teaching Hospital in Osogbo, Osun State, Nigeria
    Oluwatosin Akende, Olusola Anuoluwapo Akanbi, Adeolu Sunday Oluremi, Iheanyi Omezuruike Okonko, Oluyinka Oladele Opaleye
    Journal of Immunoassay and Immunochemistry, 2016
    Cytomegalovirus (CMV) is one of the predominant viral infections that lead to congenital diseases and teratogenic risks during the perinatal stage. There is paucity of seroepidemiological data on anti-CMV IgG antibody in pregnant women in Osogbo, Osun State, Nigeria. This study was aimed at determining the seroprevalence of Cytomegalovirus IgG antibody among pregnant women visiting antenatal clinic, LAUTECH Teaching Hospital, Osogbo, Nigeria. One hundred and seventy-four sera from the pregnant women were screened by Enzyme linked Immunosorbent Assay (ELISA) for cytomegalovirus (CMV) IgG antibody. Data analysis was done using SPSS software. In this study, 105 of the 174 pregnant women were seropositive for CMV IgG antibodies giving an antibody prevalence of 60%. There was no association found between CMV IgG seropositivity and the subjects’ demographic characteristics, however, the 60.0% prevalence of CMV-IgG antibody observed amongst pregnant women in this study demands for vaccines and regular testing for the presence of CMV and its related risk factors in antenatal clinic.
  • Trend of invasive pneumococal disease (IPD) in a south western, Nigerian hospital
    Babatunde Olanrewaju Motayo, Olusola Akingbade, Victor Nwadike, Olabode Shobayo, Joseph Ogiogwa, et al.
    Pan African Medical Journal, 2016
    The recent introduction of the Heptavalent-pneumococcal vaccine (PCV-7) by private pharmaceutical companies in Nigeria, has generated interest in invasive bacterial diseases particularly IPD. Our objective in this study is to investigate the trend and occurrence rate of IPD in Abeokuta, Nigeria. Suspected IPD cases were assessed from Jan 2010 to Dec 2010 for demographic and Microbiological characteristics. Bacterial isolations and antibiotics susceptibility testing followed standard bacteriological procedure. Overall 471 cases of probable IPD was assessed, with 21(4.5%) cases of suspected pneumonia, 109(23.1%) cases of suspected meningitis, and 341(72.4%) cases of suspected septicaemia. Confirmed IPD cases were 9 with 2 cases of meningitis, 3 cases of septicaemia and 4 cases of pneumonia. Age range distribution showed, high distribution of IPD cases among children >1 with 5(55.6%) there was a statistically significant difference in gender p< 0.05 (X2 test) with females recording a higher occurrence than males. We conclude by advocating for better detection methods against IPD meningitis cases, and continuous surveillance into the serotypes of streptococcus pneumonia as well inclusion of the PCV vaccine into our childhood immunization program.
  • Evaluation of Immunity and Seropositivity of IgG Antibodies to Canine Parvoviruses in Vaccinated and Unvaccinated Dogs in Abeokuta, Nigeria
    E. T. Babalola, O. K. Ijaopo, I. O. Okonko
    Journal of Immunoassay and Immunochemistry, 2016
  • Prevalence of IgG antibodies against human papillomavirus (HPV) type 6, 11, 16, and 18 virus-like particles in women of childbearing age in Port Harcourt, Nigeria
    I. O. Okonko, V. Ofoedu
    Journal of Immunoassay and Immunochemistry, 2015
  • Seropositivity and determinants of immunoglobulin-G (IgG) antibodies against herpes simplex virus (HSV) types-1 and-2 in pregnant women in Port Harcourt, Nigeria
    IO Okonko, TI Cookey
    African Health Sciences, 2015
  • Trends in HIV prevalence from 2008 to 2012 among young adults in Port Harcourt, Nigeria
    IO Okonko, LC Nnodim
    African Health Sciences, 2015
  • Anti-HCV antibody among newly diagnosed HIV patients in Ughelli, a suburban area of Delta State Nigeria
    OE Newton, OA Oghene, IO Okonko
    African Health Sciences, 2015
  • Triple positivity of HBsAg, anti-HCV antibody, and HIV and their influence on CD4+ lymphocyte levels in the highly HIV infected population of Abeokuta, Nigeria
    SO Ogwu-Richard, DA Ojo, OA Akingbade, IO Okonko
    African Health Sciences, 2015
  • Serum HSV-1 and -2 IgM in Pregnant Women in Port Harcourt, Nigeria
    I. O. Okonko, T. I. Cookey, P. O. Okerentugba, N. Frank-Peterside
    Journal of Immunoassay and Immunochemistry, 2015
  • Genotyping by Randomly Amplified Polymorphic DNA of Bacteriocin Producing Lactobacillus acidophilus Strains from Nigeria
    John Adeolu Alli, Bamidele A. Iwalokun, Afolabi Oluwadun, Iheanyi Omezuruike Okonko
    Journal of Immunoassay and Immunochemistry, 2015
  • HBV and HIV Coinfections among Intending Blood Donors in Port Harcourt, Nigeria
    I. O. Okonko, S. J. Horsefall, P. O. Okerentugba, N. Frank-Peterside
    Journal of Immunoassay and Immunochemistry, 2015
  • Seroepidemiology and high negativity of IgG antibodies against Human Papillomavirus (HPV) type 6, 11, 16, and 18 virus-like particles in women of childbearing age in Port Harcourt, Nigeria
    Iheanyi Omezuruike Okonko, Valentina Ofoedu, Phillip O. Okerentugba, Nnenna Frank-Peterside
    Journal of Immunoassay and Immunochemistry, 2015
  • Measles vaccine potency and sero-conversion rates among infants receiving measles immunization in Ilorin, Kwara State, Nigeria
    A. Fowotade, I. O. Okonko, C. Nwabuisi, R. A. Bakare, A. Fadeyi, et al.
    Journal of Immunoassay and Immunochemistry, 2015
  • High seropositivity of IgG and IgM antibodies against cytomegalovirus (CMV) among HIV-1 seropositive patients in Ilorin, Nigeria
    A Fowotade, IO Okonko, OO Agbede, ST Suleiman
    African Health Sciences, 2015
  • Resistant plasmid profile analysis of multidrug resistant Escherichia coli isolated from urinary tract infections in Abeokuta, Nigeria
    O Akingbade, S Balogun, D Ojo, P Akinduti, PO Okerentugba, et al.
    African Health Sciences, 2014
  • Enteroviruses as a possible cause of hypertension, dilated cardiomyopathy (DCM) and hypertensive heart failure (HHF) in south western Nigeria
    IO Okonko, AA Adebiyi, OS Ogah, FD Adu
    African Health Sciences, 2013
  • Antibiogram and plasmid profiling of carbapenemase and extended spectrum beta-lactamase (ESBL) producing Escherichia coli and Klebsiella pneumoniae in Abeokuta, South Western, Nigeria
    BO Motayo, PA Akinduti, FA Adeyakinu, PO Okerentugba, JC Nwanze, et al.
    African Health Sciences, 2013
  • Physicochemical and bacteriological studies of selected swimming pool water in Ilorin metropolis, Kwara State, Nigeria
    Stem Cell, 2013
  • Prevalence and antibiotic profile of Enterobacter species isolated from children with diarrhea in Abeokuta, Ogun State, Nigeria
    Stem Cell, 2013
  • Bacterial organisms isolated from children with diarrhoea in Abeokuta, Nigeria
    Stem Cell, 2013
  • Determination of measles hemagglutination inhibiting antibody levels among school children in Ibadan, Nigeria
    Opeyemi T. Ogundiji, Iheanyi Omezuruike Okonko, Festus D. Adu
    Journal of Immunoassay and Immunochemistry, 2013
  • Plasmid profile of isolated Klebsiella species in a tertiary hospital in Abeokuta, Ogun State, Nigeria
    World Applied Sciences Journal, 2013
  • Sabin and wild type polioviruses from children who presented with acute flaccid paralysis in Nigeria
    AO Adedeji, IO Okonko, FD Adu
    African Health Sciences, 2012
  • Comparative study of molecular and antigenic characterization for intratypic differentiation (ITD) of poliovirus strains
    A.O. Adedeji, I.O. Okonko, F.D. Adu
    Journal of Medical Virology, 2012
  • Plasmid profile analysis of multidrug resistant pseudomonas aeruginosa isolated from wound infections in South West, Nigeria
    World Applied Sciences Journal, 2012
  • Prevalence of HIV among attendees of ARFH Centre in Ibadan, Southwestern Nigeria
    Middle East Journal of Scientific Research, 2012
  • Prevalence of sexually transmitted infections (STIs) among attendees of AFRH Centre in Ibadan, Southwestern Nigeria
    Middle East Journal of Scientific Research, 2012
  • Detection of HIV-1 and -2 antibodies among freshmen of the University of Port Harcourt, Port Harcourt, Southern Nigeria
    World Applied Sciences Journal, 2012
  • Knowledge about HIV/AIDS and reported risk behaviours among freshmen of the university of Port Harcourt, Port Harcourt, Southern Nigeria
    World Applied Sciences Journal, 2012
  • Incidence of potentially pathogenic Vibrio spp. in fresh seafood from Itu creek in Uyo, Akwa Ibom State, Nigeria
    World Applied Sciences Journal, 2011
  • Phytochemical properties and in-vitro antifungal activity of Senna alata Linn. crude stem bark extract
    Journal of Medicinal Plants Research, 2011
  • Antiviral potentials of Gossypium hirsutum extracts on yellow fever virus
    Advances in Natural and Applied Sciences, 2011
  • Bacteriological evaluation of some sachet water on sales in Owerri metropolis, Imo State, Nigeria
    Malaysian Journal of Microbiology, 2011
  • Why is there still rabies in Nigeria?- A review of the current and future trends in the epidemiology, prevention, treatment, control and elimiation
    Electronic Journal of Environmental Agricultural and Food Chemistry, 2010
  • Survey of the efficacy and quality of some brands of the antibiotics sold in calabar metropolis, south-south region of Nigeria
    Electronic Journal of Environmental Agricultural and Food Chemistry, 2010
  • Assessment of the efficacies, potencies and bacteriological qualities of some of the antibiotics sold in Calabar, Nigeria
    African Journal of Biotechnology, 2010
  • Intricacies of newly emerged swine flu pandemic: A global environmental, medical and public health challenge-should the Nigeria be alarmed?
    Electronic Journal of Environmental Agricultural and Food Chemistry, 2010
  • Incidence of multi-drug resistant (MDR) organisms in some poultry feeds sold in Calabar metropolis, Nigeria
    Electronic Journal of Environmental Agricultural and Food Chemistry, 2010
  • Microbiological quality seafood processors and water used in two different sea processing plants in Nigeria
    Electronic Journal of Environmental Agricultural and Food Chemistry, 2010
  • Intricacies of newly emerged swine flu pandemic: A global environmental, medical and public health challenge-should the Nigeria be alarmed?
    Electronic Journal of Environmental Agricultural and Food Chemistry, 2010
  • Assessment of bacteriological quality of fresh meats sold in Calabar Metropolis, Nigeria
    Electronic Journal of Environmental Agricultural and Food Chemistry, 2010
  • Survey of the efficacy and quality of some brands of the antibiotics sold in Calabar Metropolis, South-south region of Nigeria
    Scientific Research and Essays, 2010
  • Detection of urinary tract infection (UTI) among pregnant women in Oluyoro Catholic Hospital, Ibadan, South-Western Nigeria
    Malaysian Journal of Microbiology, 2010
  • The role of laboratory confirmations and molecular epidemiology in global eradication of measles
    African Journal of Biotechnology, 2009
  • Microbiological quality seafood processors and water used in two different sea processing plants in Nigeria
    Electronic Journal of Environmental Agricultural and Food Chemistry, 2009
  • Waste utilization as a means of ensuring enviromental safety-an overview
    Electronic Journal of Environmental Agricultural and Food Chemistry, 2009
  • Utilization of food wastes for sustainable development
    Electronic Journal of Environmental Agricultural and Food Chemistry, 2009
  • Current trends in biofuel production and its use as an alternative energy security
    Electronic Journal of Environmental Agricultural and Food Chemistry, 2009
  • Incidence of urinary tract infection (UTI) among pregnant women in Ibadan, South-Western Nigeria
    African Journal of Biotechnology, 2009
  • The role of vaccines in elimination and global eradication of measles: A review of literature
    African Journal of Pharmacy and Pharmacology, 2009
  • Incidence of Urinary Tract Infections (UTIs) among pregnant women in Akwa metropolis, Southeastern Nigeria
    Scientific Research and Essays, 2009
  • Circulating vaccine-derived poliovirus and its implications for polio surveillance and eradication in Nigeria: A review of the literature
    Scientific Research and Essays, 2009
  • Microbiological studies on the production of anyi-a potential condiment made from laboratory fermentation of Samanea saman (monkey pod) seeds (Jacq.) Merr
    Electronic Journal of Environmental Agricultural and Food Chemistry, 2008
  • Antimicrobial chemotherapy and sustainable development: The past, the current trend, and the future
    African Journal Biomedical Research, 2008
  • Baseline Salmonella agglutinin titres in apparently healthy freshmen in Awka, South Eastern, Nigeria
    Scientific Research and Essays, 2008
  • Microbial studies on frozen shrimps processed in Ibadan and Lagos, Nigeria
    Scientific Research and Essays, 2008
  • Comparative studies and microbial risk assessment of different water samples used for processing frozen sea-foods in Ijora-olopa, Lagos State, Nigeria
    African Journal of Biotechnology, 2008
  • Comparative studies and microbial risk assessment of different Ready-to-Eat (RTE) frozen sea-foods processed in Ijora-olopa, Lagos State, Nigeria
    African Journal of Biotechnology, 2008
  • Microbiological and physicochemical analysis of different water samples used for domestic purposes in Abeokuta and Ojota, Lagos State, Nigeria
    African Journal of Biotechnology, 2008
  • Bioremediation of wastewater and municipal water treatment using latex exudate from Calotropis procera (Sodom apple)
    Electronic Journal of Environmental Agricultural and Food Chemistry, 2007
  • The role of biotechnology in the socio-economic advancement and national development: An overview
    African Journal of Biotechnology, 2006
  • Microbial studies on Aisa: A potential indigenous laboratory fermented food condiment from Albizia saman (Jacq.) F. Mull
    Adenike A.O. Ogunshe, Abiodun E. Ayodele, Iheanyi O. Okonko
    Pakistan Journal of Nutrition, 2006

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    Scientia Africana 24 (2), 199-210 , 2025
    2025
  • EFFECT OF MALARIA ON THE RETICULOCYTE COUNT OF FEMALE STUDENTS OF A UNIVERSITY IN ELELE, RIVERS STATE
    CC Echiejini, AI Ezeamalu, QM Muoghara, SE Idimogu, RA Ikpeama, ...
    medRxiv, 2025.05. 25.25328311 , 2025
    2025
  • SEROPREVALENCE OF HEPATITIS-E VIRUS (HEV) AMONGST MEAT HANDLERS IN IRRUA, EDO STATE, NIGERIA.
    EC WEMAMBU, IO OKONKO, N FRANK-PETERSIDE
    African Journal of Health, Safety and Environment 6 (1), 49-57 , 2025
    2025
  • Antimicrobial activity of curry leaf (Murraya keonigii) extracts: an in-vitro study
    O Osuala, A Mmezi, C Ezemba, C Chukwuma, N Okeke, V Etikudike, O Oli, ...
    Covenant Journal Of Physical And Life Sciences , 2025
    2025
    Citations: 4
  • EPIDEMIOLOGY AND CO-INFECTION ANALYSIS AMONG HIV-INFECTED INDIVIDUALS PRESENTING AT A TEACHING HOSPITAL IN BAYELSA STATE, NIGERIA
    K Okon, A Affia, F Adeniji, P OKERENTUGBA, I Okonko
    Covenant Journal of Physical and Life Sciences , 2025
    2025
  • Chlamydia trachomatis infection among young adults residing at the University of Port-Harcourt hostels in Rivers State Nigeria.
    IO Okonko, PU John, E Enya, BJ Okonko, CC Adim, EN Onu, ...
    Scientia Africana 23 (4), 97-106 , 2024
    2024
  • SEROLOGICAL EVIDENCE OF HBc IgM AMONG HIV-INFECTED INDIVIDUALS ATTENDING SELECTED HOSPITALS IN ANAMBRA STATE, NIGERIA
    E Oketah, C Ugwu, N Frank-Peterside, I Okonko
    Covenant Journal of Physical and Life Sciences , 2024
    2024
  • PREVALENCE AND CO-INFECTION OF HELICOBACTER PYLORI AND HEPATITIS C VIRUS AMONG HIV PATIENTS ON ART IN PORT HARCOURT, NIGERIA
    I Okonko, O DIAMEREYAN, N Frank-Peterside
    Covenant Journal of Physical and Life Sciences , 2024
    2024
  • Evaluation of the Microbiota and Bioactive Compounds in Traditional and Industrially Produced Vinegar
    OJ Osuala, CC Ezemba, AS Ezemba, C Chude, P Ezemba, E Odion, ...
    Available at SSRN 5020801 , 2024
    2024
  • Microbial contamination and antibiotic resistance in selected yoghurt brands in Elele, Rivers State, Nigeria
    M ANAGBOSO, C Ohaebuka, E Mbah, O Osuala, ...
    Covenant Journal of Physical and Life Sciences , 2024
    2024
    Citations: 3
  • Helicobacter pylori and Treponema pallidum (syphilis) co-infection among HIV patients attending a private clinic in Warri, Delta State, Nigeria
    HC Innocent-Adiele, HO Iheanacho, O Osuala, CG Daokoru-Olukole, ...
    Scientia Africana 23 (3), 395-408 , 2024
    2024
  • ASSESSMENT OF MICROBIOLOGICAL CONTAMINATION ON COMPUTER KEYBOARDS IN OFFICE SETTINGS: A CASE STUDY AT MADONNA UNIVERSITY, ELELE, RIVERS STATE, NIGERIA
    J Edidiong, S Njoku, O Osuala, EEI Mbah, C Daokoru-Olukole, E Onu, ...
    Covenant Journal of Physical and Life Sciences , 2024
    2024
  • Evaluation and Validation of four Rapid Diagnostic test (RDTs) kits available for SARS-CoV-2 Detection in Rivers State, Nigeria
    A Justice, AM Awanye, N Frank-Peterside, TI Cookey, CNE Ibezim, ...
    2024
  • Detection of syphilis among patients attending a General Hospital in Ogbakiri, River State, Nigeria
    TI Cookey, DS Isheke, M Elenwo, CM Enemchukwu, HC Innocent-Adiele, ...
    Scientia Africana 23 (2), 175-182 , 2024
    2024
    Citations: 2
  • Detection and Prevalence of Syphilis, Hepatitis C Virus and Helicobacter pylori Co-Infection among Pregnant Women attending Primary Health Centre, Mbodo …
    CC Adim, FH Nnamdi, CD Ugboma, TI Cookey, HC Innocent-Adiele, ...
    medRxiv, 2024.03. 22.24304749 , 2024
    2024
  • Perceived Impact of COVID-19 Pandemic on Social Health of Single Mothers in Rivers State, Nigeria
    N GA, A BN, G CC, I DU, O RN, K AJ, A NC, E EO, I MU, O FO, U FB, A NJ, ...
    Asian Journal of Research in Nursing and Health 7 (1), 63-69 , 2024
    2024

MOST CITED SCHOLAR PUBLICATIONS

  • Microbiological and physicochemical analysis of different water samples used for domestic purposes in Abeokuta and Ojota, Lagos State, Nigeria
    OI Omezuruike, AO Damilola, OT Adeola, EA Fajobi, OB Shittu
    African journal of Biotechnology 7 (5), 617-621 , 2008
    2008
    Citations: 374
  • Incidence of urinary tract infection (UTI) among pregnant women in Ibadan, South-Western Nigeria
    IO Okonko, LA Ijandipe, OA Ilusanya, OB Donbraye-Emmanuel, J Ejembi, ...
    African Journal of Biotechnology 8 (23) , 2009
    2009
    Citations: 220
  • Assessment of bacteriological quality of fresh meats sold in Calabar metropolis, Nigeria.
    IO Ukut, IO Okonko, IS Ikpoh, AO Nkang, AO Udeze, TA Babalola, ...
    Electronic Journal of Environmental, Agricultural & Food Chemistry 9 (1) , 2010
    2010
    Citations: 157
  • Incidence of multi-drug resistance (MDR) organisms in Abeokuta, Southwestern Nigeria
    IO Okonko, FA Soleye, TA Amusan, AA Ogun, TA Ogunnusi, J Ejembi, ...
    Global journal of pharmacology 3 (2), 69-80 , 2009
    2009
    Citations: 137
  • Incidence of urinary tract infections (UTIs) among pregnant women in Akwa metropolis, Southeastern Nigeria
    CH Obiogbolu, IO Okonko, CO Anyamere, AO Adedeji, AO Akanbi, ...
    Sci Res Essays 4 (8), 820-824 , 2009
    2009
    Citations: 136
  • Antimicrobial activity of Zingiber officinale (ginger) extract against some selected pathogenic bacteria
    OA Akintobi, CC Onoh, JO Ogele, AA Idowu, OV Ojo, IO Okonko
    Nature and science 11 (1), 7-15 , 2013
    2013
    Citations: 122
  • Microbial ecology of organisms causing pawpaw (Carica papaya L.) fruit decay in Oyo State, Nigeria
    KS Chukwuka, IO Okonko, AA Adekunle
    American-Eurasian Journal of Toxicological Sciences 2 (1), 43-50 , 2010
    2010
    Citations: 122
  • Hazards analysis critical control points (HACCP) and microbiology qualities of sea-foods as affected by handler's hygience in Ibadan and Lagos, Nigeria.
    IO Okonko, OD Adejoye, AA Ogun, AA Ogunjobi, AO Nkang, ...
    2009
    Citations: 121
  • In vitro antifungal activity of Senna alata Linn. crude leaf extract.
    WF Sule, IO Okonko, TA Joseph, MO Ojezele, JC Nwanze, JA Alli, ...
    2010
    Citations: 115
  • Phytochemical properties and in-vitro antifungal activity of Senna alata Linn. crude stem bark extract
    WF Sule, IO Okonko, S Omo-Ogun, JC Nwanze, MO Ojezele, OJ Ojezele, ...
    Journal of medicinal plants research 5 (2), 176-183 , 2011
    2011
    Citations: 114
  • Microorganisms associated with spoilage of stored vegetables in Uyo Metropolis, Akwa Ibom State, Nigeria
    BC Adebayo-Tayo, NN Odu, CU Esen, IO Okonko
    Nature and science 10 (3), 23-32 , 2012
    2012
    Citations: 110
  • Comparative studies and microbial risk assessment of different water samples used for processing frozen sea-foods in Ijora-olopa, Lagos State, Nigeria
    IO Okonko, AA Ogunjobi, OD Adejoye, TA Ogunnusi, MC Olasogba
    African journal of Biotechnology 7 (16), 2902-2907 , 2008
    2008
    Citations: 104
  • Plant growth promoting rhizobacteria (PGPR) as biofertilizer: Effect on growth of Lycopersicum esculentus
    AA Ibiene, JU Agogbua, IO Okonko, GN Nwachi
    Journal of American Science 8 (2), 318-324 , 2012
    2012
    Citations: 97
  • Antibiotics sensitivity and resistance patterns of uropathogens to nitrofurantoin and nalidixic acid in pregnant women with urinary tract infections in Ibadan, Nigeria
    A Udeze
    Middle-East Journal of Scientific Research , 2009
    2009
    Citations: 96
  • Utilization of food wastes for sustainable development
    IO Okonko, OT Adeola, FE Aloysius, AO Damilola, OA Adewale
    Electr J Environ Agric Food Chem 8 (4), 263-286 , 2009
    2009
    Citations: 95
  • Detection of urinary tract infection (UTI) among pregnant women in Oluyoro Catholic Hospital, Ibadan, South-Western Nigeria
    I Okonko
    Malaysian Journal of… , 2009
    2009
    Citations: 94
  • Microbial quality of frozen fish sold in Uyo Metropolis
    BC Adebayo-Tayo, NN Odu, LM Anyamele, N Igwiloh, IO Okonko
    Nature and science 10 (3), 71-77 , 2012
    2012
    Citations: 88
  • Plasmid profile analysis of multidrug resistant Pseudomonas aeruginosa isolated from wound infections in South West, Nigeria
    M Ibrahim
    World Applied Sciences Journal , 2012
    2012
    Citations: 87
  • Prevalence of intestinal nematode infection among pregnant women attending antenatal clinic at the University College Hospital, Ibadan, Nigeria
    JA Alli, IO Okonko, AF Kolade, JC Nwanze, VK Dada, M Ogundele
    Advances in Applied Science Research 2 (4), 1-13 , 2011
    2011
    Citations: 81
  • The antimicrobial activities of some medicinal plants on Escherichia coli as an agent of diarrhea in livestock.
    KS Chukwuka, JO Ikheloa, IO Okonko, JO Moody, TA Mankinde
    2011
    Citations: 78

Publications

Banin, A.N., Tuen, M., Bimela, J.S., Tongo, M., Zappile, P., Khodadadi-Jamayran, A., Nanfack, A., Okonko, I.O., Meli, J., Wang, X., Mbanya, D., Ngogang, J., Gorny, M.K., Heguy, A., Nyambi, P., Fokunang, C. & Duerr, R. (2019). Near Full Genome Characterization of HIV-1 Unique Recombinant Forms in Cameroon reveals dominant CRF02_AG and F2 recombination patterns. Journal of the International AIDS Society, 22(7):e25362.
Okonko, I. O. & Okoli, E. M. (2020). Determination of antibodies to human immunodeficiency virus type 1&2&O and P24 – antigen in pregnant women in Port Harcourt Nigeria. Journal of Immunoassay and Immunochemistry, 41 (2): 208-218
Okonko, I. O., Makinde, T. S., Okonko, B. J. & Ogbu, O. (2020). Immunological and epidemiological evaluation of EBV infections among HIV-1 infected individuals in Abakaliki, Nigeria supports the potential use of neutrophils as a marker of EBV in HIV disease progression and as useful markers of immune activation. Journal of Immunoassay and Immunochemistry, 41 (2): 158-170
Okonko, I.O. & Egbogon, J. (2022). Plasma Immunoglobulin-G (IgG) Against Epstein Barr Virus Nuclear Antigens Among University Students in Port Harcourt, Nigeria. Biotechnology, 21:10-19
Okonko, I.O., Okobia, V. C., Cookey, T. I., & Innocent-Adiele, H. C. (2022). Dual Positivity of Human Immunodeficiency Virus (HIV) and Hepatitis B Virus (HBV) In the Highly Infected Population of Rivers State, Nigeria. Report & Opinion, 14(10):1-9

GRANT DETAILS

2021 Tertiary Education Trust Fund (TETFund) Institution-Based Research (IBR) Grant (TETF/UPH/IBR/2019/7/009). A Grant to support my research on “Evaluation and Validation of COVID-19 Rapid Diagnostic Testing (RDTs)” under the Year(s) 2014-2019 TETFund Intervention in Research Project (RP) for Institution-Based Research (IBR).
2021 Tertiary Education Trust Fund (TETFund) Institution-Based Research (IBR) Grant (TETF/UPH/IBR/2019/7/006). A Grant to support my research on “Unravelling the genetic diversity of HIV-1 sequence markers that are associated with disease parameters in HIV-1 positive individuals in Port Harcourt, Nigeria” under the Year(s) 2014-2019 TETFund Intervention in Research Project (RP) for Institution-Based Research (IBR).
2021 Tertiary Education Trust Fund (TETFund) Institution-Based Research (IBR) Grant (TETF/UPH/IBR/2019/7/002). A Grant to support my research on “Knowledge, attitude, perception of tetanus toxoid vaccination and assessment of immunity to tetanus among residents of Obio-Akpor LGA, Rivers state, Nigeria” under the Year(s) 2014-2019 TETFund Intervention in Research Project (RP) for Institution-Based Research (IBR).
2016-2018: African Doctoral Dissertation Research Fellowship (ADDRF) HIV Award. by African Population and Health Research Center (APHRC), Nairobi, Kenya in partnership with the International Development Research Centre (IDRC), Canada.
2016-2017: Fulbright Visiting Research Scholar Fellowship

SOCIAL, ECONOMIC, or ACADEMIC BENEFITS

A Fulbright Visiting Fellowship to the New York University School of Medicine (NYUSoM), New York, United States-A program of the United States Department of State Bureau of Educational and Cultural Affairs targeted at young and exceptionally promising Faculty members who wish to conduct their doctoral research in the United States and designed primarily to strengthen capacities of African Universities through higher degree training and to develop the potential of their academic staff.