Alexandru Rotaru

@icmpp.ro



              

https://researchid.co/rotaru.alexandru
5

Scopus Publications

189

Scholar Citations

1

Scholar h-index

2

Scholar i10-index

Scopus Publications

  • Assembly and stability of trastuzumab-conjugated and unmodified poly(L-histidine)-poly(ethylene glycol) micelles for targeting HER2-positive cells
    Razvan Ghiarasim, Gabriel Luta, Mihail-Gabriel Dimofte, Tore-Geir Iversen, Mariana Pinteala, and Alexandru Rotaru
    Elsevier BV

  • Synergistic Antibacterial Action of Norfloxacin-Encapsulated G4 Hydrogels: The Role of Boronic Acid and Cyclodextrin
    Monica-Cornelia Sardaru, Irina Rosca, Simona Morariu, Elena-Laura Ursu, and Alexandru Rotaru
    MDPI AG
    In this present study, we developed and characterized a series of supramolecular G4 hydrogels by integrating β-cyclodextrin (β-CD) and boronic acid linkers into a supramolecular matrix to enhance antibacterial activity against Staphylococcus aureus (S. aureus). We systematically investigated how varying the number of free boronic acid moieties (ranging from two to six), along with guanosine and β-CD content, influences both the structural integrity and antimicrobial efficacy of these materials. Comprehensive characterization using FTIR, circular dichroism, X-ray diffraction, SEM, AFM, and rheological measurements confirmed successful synthesis and revealed that higher boronic acid content correlated with a stronger, more organized network. The most effective hydrogel displayed an inhibition zone of 25 mm in disk diffusion assays, and was further explored as a drug delivery platform, with the aim to exploit the capacity of the free β-CD cavity of the hydrogels to incorporate hydrophobic drugs. Norfloxacin (Nfx), a poorly water-soluble antibiotic, was successfully encapsulated within the hydrogel matrix through the inclusion of complex formation with β-CD, improving its solubility and enabling sustained, targeted release. The Nfx-loaded hydrogel expanded the inhibition zone to 49 mm and completely eradicated S. aureus cells within 24 h, outperforming both the unloaded hydrogel and free Nfx. These results highlight the synergistic effect of boronic acid moieties and controlled drug release, underlining the potential of these hydrogels as versatile platforms for localized antimicrobial therapy, such as in wound dressings or implant coatings. Nevertheless, further in vivo studies and long-term stability assessments are needed to fully establish clinical relevance, safety, and scalability before these systems can be translated into routine healthcare applications.

  • Photothermal Hydrogel Composites Featuring G4-Carbon Nanomaterial Networks for Staphylococcus aureus Inhibition
    Monica-Cornelia Sardaru, Irina Rosca, Cristian Ursu, Ioan-Andrei Dascalu, Elena-Laura Ursu, Simona Morariu, and Alexandru Rotaru
    American Chemical Society (ACS)


  • 3D-Shaped Binders of Unfolded Proteins Inducing Cancer Cell-Specific Endoplasmic Reticulum Stress In Vitro and In Vivo
    Insa Klemt, Oleg Varzatskii, Roman Selin, Serhii Vakarov, Vladyslava Kovalska, Galyna Bila, Rostyslav Bilyy, Yan Voloshin, Itziar Cossío Cuartero, Andrés Hidalgo,et al.
    American Chemical Society (ACS)
    The amount of unfolded proteins is increased in cancer cells, leading to endoplasmic reticulum (ER) stress. Therefore, cancer cells are sensitive to drugs capable of further enhancing ER stress. Examples of such drugs include the clinically approved proteosome inhibitors bortezomib and carfilzomib. Unfortunately, the known ER stress inducers exhibit dose-limiting side effects that justify the search for better, more cancer-specific drugs of this type. Herein, we report on FeC 2, which binds to unfolded proteins prevents their further processing, thereby leading to ER stress and ROS increase in cancer cells, but not in normal cells. FeC 2 exhibits low micromolar toxicity toward human acute promyelocytic leukemia HL-60, Burkitt's lymphoma BL-2, T-cell leukemia Jurkat, ovarian carcinoma A2780, lung cancer SK-MES-1, and murine lung cancer LLC1 cells. Due to the cancer-specific mode of action, 2 is not toxic in vivo up to the dose of 147 mg/kg, does not affect normal blood and bone marrow cells at the therapeutically active dose, but strongly suppresses both primary tumor growth (confirmed in Nemeth-Kellner lymphoma and LLC1 lung cancer models of murine tumor) and spreading of metastases (LLC1).

  • Nucleic Acid Probes in Bio-Imaging and Diagnostics: Recent Advances in ODN-Based Fluorescent and Surface-Enhanced Raman Scattering Nanoparticle and Nanostructured Systems
    Monica-Cornelia Sardaru, Narcisa-Laura Marangoci, Rosanna Palumbo, Giovanni N. Roviello, and Alexandru Rotaru
    MDPI AG
    Raman nanoparticle probes are a potent class of optical labels for the interrogation of pathological and physiological processes in cells, bioassays, and tissues. Herein, we review the recent advancements in fluorescent and Raman imaging using oligodeoxyribonucleotide (ODN)-based nanoparticles and nanostructures, which show promise as effective tools for live-cell analysis. These nanodevices can be used to investigate a vast number of biological processes occurring at various levels, starting from those involving organelles, cells, tissues, and whole living organisms. ODN-based fluorescent and Raman probes have contributed to the achievement of significant advancements in the comprehension of the role played by specific analytes in pathological processes and have inaugurated new possibilities for diagnosing health conditions. The technological implications that have emerged from the studies herein described could open new avenues for innovative diagnostics aimed at identifying socially relevant diseases like cancer through the utilization of intracellular markers and/or guide surgical procedures based on fluorescent or Raman imaging. Particularly complex probe structures have been developed within the past five years, creating a versatile toolbox for live-cell analysis, with each tool possessing its own strengths and limitations for specific studies. Analyzing the literature reports in the field, we predict that the development of ODN-based fluorescent and Raman probes will continue in the near future, disclosing novel ideas on their application in therapeutic and diagnostic strategies.

  • Dynameric G-quadruplex-dextran hydrogels for cell growth applications
    Monica-Cornelia Sardaru, Simona Morariu, Oana-Elena Carp, Elena-Laura Ursu, Alexandru Rotaru, and Mihail Barboiu
    Royal Society of Chemistry (RSC)
    Hybrid dextran–G-quartet dynamers produces tunable biocompatible three-dimensional thixotropic hydrogels, able to support cell growth.

  • Solid-Phase Synthesized Copolymers for the Assembly of pH-Sensitive Micelles Suitable for Drug Delivery Applications
    Razvan Ghiarasim, Crina Elena Tiron, Adrian Tiron, Mihail-Gabriel Dimofte, Mariana Pinteala, and Alexandru Rotaru
    MDPI AG
    Diblock copolymers of polyhistidine are known for their self-assembly into micelles and their pH-dependent disassembly due to the amphiphilic character of the copolymer and the unsaturated imidazole groups that undergo a hydrophobic-to-hydrophilic transition in an acidic pH. This property has been largely utilized for the design of drug delivery systems that target a tumor environment possessing a slightly lower extracellular pH (6.8–7.2). The main purpose of this study was to investigate the possibility of designed poly(ethylene glycol)-polyhistidine sequences synthesized using solid-phase peptide synthesis (SPPS), to self-assemble into micelles, to assess the ability of the corresponding micelles to be loaded with doxorubicin (DOX), and to investigate the drug release profile at pH values similar to a malignant extracellular environment. The designed and assembled free and DOX-loaded micelles were characterized from a physico-chemical point of view, their cytotoxicity was evaluated on a human breast cancer cell line (MDA-MB-231), while the cellular areas where micelles disassembled and released DOX were assessed using immunofluorescence. We concluded that the utilization of SPPS for the synthesis of the polyhistidine diblock copolymers yielded sequences that behaved similarly to the copolymeric sequences synthesized using ring-opening polymerization, while the advantages of SPPS may offer facile tuning of the histidine site or the attachment of a large variety of functional molecules.

  • Monomethine cyanine probes for visualization of cellular RNA by fluorescence microscopy
    Daria Aristova, Viktoriia Kosach, Svitlana Chernii, Yuriy Slominsky, Anatoliy Balanda, Valeriy Filonenko, Sergiy Yarmoluk, Alexandru Rotaru, Hülya Gizem Özkan, Andriy Mokhir,et al.
    IOP Publishing
    Abstract We have studied spectral-luminescent properties of the monomethine cyanine dyes both in their free states and in the presence of either double-stranded deoxyribonucleic acids (dsDNAs) or single-stranded ribonucleic acids (RNAs). The dyes possess low fluorescence intensity in an unbound state, which is increased up to 479 times in the presence of the nucleic acids. In the presence of RNAs, the fluorescence intensity increase was stronger than that observed in the presence of dsDNA. Next, we have performed staining of live and fixed cells by all prepared dyes. The dyes proved to be cell and nuclear membrane permeant. They are photostable and brightly stain RNA-containing organelles in both live and fixed cells. The colocalization confirmed the specific nucleoli staining with anti-Ki-67 antibodies. The RNA digestion experiment has confirmed the selectivity of the dyes toward intracellular RNA. Based on the obtained results, we can conclude that the investigated monomethine cyanine dyes are useful fluorescent probes for the visualization of intracellular RNA and RNA-containing organelles such as nucleoli by using fluorescence microscopy.

  • Injectable thixotropic β–cyclodextrin–functionalized hydrogels based on guanosine quartet assembly
    Monica-Cornelia Sardaru, Irina Rosca, Simona Morariu, Elena-Laura Ursu, Razvan Ghiarasim, and Alexandru Rotaru
    MDPI AG
    Facile method for the preparation of β–cyclodextrin–functionalized hydrogels based on guanosine quartet assembly was described. A series of seven hydrogels were prepared by linking β–cyclodextrin molecules with guanosine moieties in different ratios through benzene–1,4–diboronic acid linker in the presence of potassium hydroxide. The potassium ions acted as a reticulation agent by forming guanosine quartets, leading to the formation of self–sustained transparent hydrogels. The ratios of the β–cyclodextrin and guanosine components have a significant effect on the internal structuration of the components and, correspondingly, on the mechanical properties of the final gels, offering a tunablity of the system by varying the components ratio. The insights into the hydrogels’ structuration were achieved by circular dichroism, scanning electron microscopy, atomic force microscopy, and X–ray diffraction. Rheological measurements revealed self–healing and thixotropic properties of all the investigated samples, which, in combination with available cyclodextrin cavities for active components loading, make them remarkable candidates for specific applications in biomedical and pharmaceutical fields. Moreover, all the prepared samples displayed selective antimicrobial properties against S. aureus in planktonic and biofilm phase, the activity also depending on the guanosine and cyclodextrin ratio within the hydrogel structure.


  • Supramolecular guanosine-quadruplex hydrogels and hydrogel composites for cell growth applications
    Elena Laura Ursu and Alexandru Rotaru
    Springer International Publishing

  • New 2,9-disubstituted-1,10-phenanthroline derivatives with anticancer activity by selective targeting of telomeric G-quadruplex DNA
    Anda-Mihaela Craciun, Alexandru Rotaru, Corneliu Cojocaru, Ionel I. Mangalagiu, and Ramona Danac
    Elsevier BV

  • Cyclodextrin encapsulated pH sensitive dyes as fluorescent cellular probes: Self-aggregation and in vitro assessments
    Monica-Cornelia Sardaru, Oana Carp, Elena-Laura Ursu, Anda-Mihaela Craciun, Corneliu Cojocaru, Mihaela Silion, Vladyslava Kovalska, Ionel Mangalagiu, Ramona Danac, and Alexandru Rotaru
    MDPI AG
    We have designed and synthesized a series of novel, supramolecular, long-lived fluorescent probes based on the host-guest inclusion complexes formation between fluorescent indolizinyl-pyridinium salts and β-cyclodextrin. Fluorescence and electrospray ionisation mass spectrometry experiments, supported by theoretical molecular docking studies, were utilized in the monitoring of the inclusion complexes formation, evidencing the appearance of corresponding 1:1 and 1:2 species. Additionally, the influence of the guest molecule over the aggregation processes of the cyclodextrin inclusion complexes was investigated by transmission electron microscopy. The absence of cytotoxicity, cellular permeability, long-lived intracellular fluorescence, and in time specific accumulation within acidic organelles identified the investigated supramolecular entities as remarkable candidates for intracellular fluorescence probes. Co-staining experiments using specific organelle markers revealed the fact that, after a 24-h incubation period, the inclusion complexes accumulate predominantly in lysosomes rather than in mitochondria. This study opens new possibilities for a broad range of fluorescent dyes with solubility and high toxicity issues, able to form inclusion complexes with β-cyclodextrin, to be tested as intracellular fluorescence probes.

  • The use of C<inf>1</inf> symmetry imidazole-carboxylate building block and auxiliary acetate co-ligand for assembly of a 2D wave-like zinc(II) coordination polymer: experimental and theoretical study
    Dana Bejan, Lucian Gabriel Bahrin, Corneliu Cojocaru, Alexandru Florentin Trandabat, Narcisa Laura Marangoci, Alexandru Rotaru, and Sergiu Shova
    Informa UK Limited
    Abstract We report the synthesis and characterization of a two-dimensional Zn(II) coordination polymer employing a ligand with a biphenyl core containing imidazole and carboxylate groups in the presence of acetate moieties as bridging molecules. The obtained [ZnLAc]n was structurally characterized via X-ray, FTIR, TGA, PXRD, SEM and EDX analyses. Computer-aided calculations based on density functional theory (DFT) were employed to assess the optimal conformational geometries of both the starting ligand and the Zn(II) complex. Computational results were compared with the experimental data, disclosing a reasonable agreement. Comparisons between the single-crystal structures and the calculated optimized geometries of the molecular entities are discussed. In addition, the time-dependent DFT method (TD-DFT) was applied to assess the first excited state of the ligand and complex. Graphical Abstract

  • Single-walled carbon nanotubes–G-quadruple hydrogel nanocomposite matrixes for cell support applications
    Elena-Laura Ursu, Gabriela Gavril, Simona Morariu, Mariana Pinteala, Mihail Barboiu, and Alexandru Rotaru
    Elsevier BV

  • 2,4,6-Tris(4-Iodophenyl)-1,3,5-Trimethylbenzene
    Dana Bejan, Narcisa Laura Marangoci, Alexandru Rotaru, Alexandru Florentin Trandabat, and Lucian Gabriel Bahrin
    MDPI AG
    2,4,6-Tris(4-iodophenyl)-1,3,5-trimethylbenzene was synthesized from 2,4,6-triphenyl-1,3,5-trimethylbenzene, using [bis(trifluoroacetoxy)iodo]benzene as the iodinating agent. The title compound was characterized by means of NMR, IR, and mass spectrometry, as well as TG analysis.

  • Photophysics of poly(3,4-ethylenedioxythiophene) covered by permodified γ-cyclodextrin
    Ana-Maria Resmerita, Aurelian D. Costea, Flavian Farcas, Angela Rotaru, and Aurica Farcaș
    SPIE
    Poly(3,4-ethylenedioxythiophene/permethylated γ-cyclodextrin) polyrotaxane (PEDOT∙TMγCD) having bulky triphenylmethyl as stoppers was synthesized by the chemical oxidation of 3,4-ethylenedioxythiophene (EDOT) as an inclusion complex with 2,3,6-tri-O-methyl γ-cyclodextrin (TMγCD) (EDOT∙TMγCD) with a five-fold excess of iron (III) chloride oxidant over the stoichiometric amount in water. For a comparison, the reference PEDOT was synthesized under the same experimental conditions. The chemical structures of the synthesized compounds were proved by FT-IR and NMR spectroscopies. The coverage ratio of the EDOT and PEDOT backbones was found to be of 80.0 % and 43.7 %, respectively. Differential scanning calorimetry (DSC) studies of both PEDOT and PEDOT∙TMγCD samples showed no crystallization or melting peaks in the range 20-200 °C. The PEDOT∙TMγCD as dark-green powders was enough soluble in acetone, dichloromethane, CHCl3 and THF compared with those of the reference PEDOT. The optical properties of the PEDOT and PEDOT∙TMγCD compounds were investigated by UV-Vis. The UV-Vis absorption spectrum of PEDOT∙TMγCD in THF is consistent with the spectrum of the PEDOT in DMSO. Atomic force microscopy, AFM, indicated that the PEDOT∙TMγCD film is more uniformly distributed over the substrate area compared with those of the reference PEDOT. The electrochemical data provided that the investigated PEDOT∙TMγCD exhibited n- and p-doping processes. The HOMO/LUMO energy level indicates that the investigated PEDOT∙TMγCD polyrotaxane is electrochemically accessible as electron-transporting material in electronic devices.

  • Synthesis, structure, computational modeling, and biological activity of two novel bimesitylene derivatives
    Lucian G. Bahrin, Lilia Clima, Sergiu Shova, Irina Rosca, Corneliu Cojocaru, Dana Bejan, Monica C. Sardaru, Narcisa Marangoci, Vasile Lozan, and Alexandru Rotaru
    Springer Science and Business Media LLC

  • Mass Spectrometry as a Complementary Approach for Noncovalently Bound Complexes Based on Cyclodextrins
    Mihaela Silion, Adrian Fifere, Ana Lacramioara Lungoci, Narcisa Laura Marangoci, Sorin Alexandru Ibanescu, Radu Zonda, Alexandru Rotaru, and Mariana Pinteală
    Springer International Publishing

  • Zinc(II) coordination polymer on the base of 3′-(1H-tetrazol-5-yl)-[1,1′-biphenyl]-4-carboxylic acid: Synthesis, crystal structure and antimicrobial properties
    Lucian G. Bahrin, Irina Rosca, Lilia Clima, Sergiu Shova, Dana Bejan, Alina Nicolescu, Narcisa-Laura Marangoci, Monica C. Sardaru, Vasile Lozan, and Alexandru Rotaru
    Elsevier BV

  • The effect of the macrocyclic encapsulation on the photophysical properties of conjugated polymers
    Aurica Farcas, Mihaela Balan-Porcarasu, Ana-Maria Resmerita, Mihai Asandulesa, Angela Rotaru, and Flavian Farcas
    SPIE
    We report the effect of the macrocyclic encapsulation on the photophysical properties of poly(9,9-dioctylfluorene-alt-bithiophene) polyrotaxanes copolymers. The encapsulated compounds were synthesized by Suzuki cross-coupling reaction between 5,5'-dibromo-2,2'-bithiophene (DBT) inclusion complexes in randomly methylated β-cyclodextrin (RM-βCD), 2,3,6-tri-O-methyl β-cyclodextrin (TM-βCD), 2,3,6-tri-O-trimethylsilyl β-cyclodextrin (TMS-βCD) or cucurbit[7]uril (CB7) with a bulky 9,9-dioctylfluorene-2,7-diboronic acid bis(1,3-propanediol) ester (DF) as stoppers. These supramolecular compounds exhibited distinct improvement in the solubility, molecular weight, film forming ability, surface-morphological characteristics and reduced aggregation tendency compared to those of the neat compound. Also, the threading of conjugated backbones into macrocycles leads to an increasing environmental stability and resistance to quenching from impurities. Fluorescence emission (PL) shows vibronic transitions and a mono-exponential kinetics. The electrochemical data provided that the investigated compounds exhibited n- and p-doping processes. The encapsulation of DBT into TM-βCD or TMS-βCD cavities exhibits a greater effect on the LUMO, while the encapsulation into CB7 affects the HOMO energy levels. The HOMO/LUMO energy levels indicate that the investigated polyrotaxanes are electrochemically accessible as electron-transporting materials in electronic devices. Based on AFM analysis, polyrotaxane compounds exhibits a higher tendency to organize into fibers or linear ribbons.

  • Polyplex formation between cyclodextrin-based non-viral vector and dsdna: Molecular dynamic study with experimental validation


  • Novel cyclodextrin-based pH-sensitive supramolecular host-guest assembly for staining acidic cellular organelles
    Gabriela Pricope, Elena Laura Ursu, Monica Sardaru, Corneliu Cojocaru, Lilia Clima, Narcisa Marangoci, Ramona Danac, Ionel I. Mangalagiu, Bogdan C. Simionescu, Mariana Pinteala,et al.
    Royal Society of Chemistry (RSC)
    A novel supramolecular approach for the preparation of new non-toxic systems for staining cellular organelles is described.

  • Optimization of polyplex formation between DNA oligonucleotide and poly(L-Lysine): Experimental study and modeling approach
    Tudor Vasiliu, Corneliu Cojocaru, Alexandru Rotaru, Gabriela Pricope, Mariana Pinteala, and Lilia Clima
    MDPI AG
    The polyplexes formed by nucleic acids and polycations have received a great attention owing to their potential application in gene therapy. In our study, we report experimental results and modeling outcomes regarding the optimization of polyplex formation between the double-stranded DNA (dsDNA) and poly(l-Lysine) (PLL). The quantification of the binding efficiency during polyplex formation was performed by processing of the images captured from the gel electrophoresis assays. The design of experiments (DoE) and response surface methodology (RSM) were employed to investigate the coupling effect of key factors (pH and N/P ratio) affecting the binding efficiency. According to the experimental observations and response surface analysis, the N/P ratio showed a major influence on binding efficiency compared to pH. Model-based optimization calculations along with the experimental confirmation runs unveiled the maximal binding efficiency (99.4%) achieved at pH 5.4 and N/P ratio 125. To support the experimental data and reveal insights of molecular mechanism responsible for the polyplex formation between dsDNA and PLL, molecular dynamics simulations were performed at pH 5.4 and 7.4.

RECENT SCHOLAR PUBLICATIONS

  • Assembly and stability of trastuzumab-conjugated and unmodified poly (L-histidine)-poly (ethylene glycol) micelles for targeting HER2-positive cells
    R Ghiarasim, G Luta, MG Dimofte, TG Iversen, M Pinteala, A Rotaru
    Journal of Molecular Liquids 418, 126689 2025

  • Synergistic Antibacterial Action of Norfloxacin-Encapsulated G4 Hydrogels: The Role of Boronic Acid and Cyclodextrin
    MC Sardaru, I Rosca, S Morariu, EL Ursu, A Rotaru
    Gels 11 (1), 35 2025

  • Photothermal Hydrogel Composites Featuring G4-Carbon Nanomaterial Networks for Staphylococcus aureus Inhibition
    MC Sardaru, I Rosca, C Ursu, IA Dascalu, EL Ursu, S Morariu, A Rotaru
    ACS omega 9 (14), 15833-15844 2024

  • Antimicrobial, antiproliferative and dna-interacting properties of 6-(2, 4-dichlorobenzoyl)-7-(2, 4-dichlorophenyl) indolo [3, 4-jk] phenanthridin-5 (4h)-one
    E Gorincioi, V Pogrebnoi, D Iunac, G Balan, AV Rotaru, N Sucman, ...
    Materials Science and Condensed Matter Physics, 107-107 2024

  • 3D-Shaped Binders of Unfolded Proteins Inducing Cancer Cell-Specific Endoplasmic Reticulum Stress In Vitro and In Vivo
    I Klemt, O Varzatskii, R Selin, S Vakarov, V Kovalska, G Bila, R Bilyy, ...
    Journal of the American Chemical Society 145 (40), 22252-22264 2023

  • Nucleic Acid Probes in Bio-Imaging and Diagnostics: Recent Advances in ODN-Based Fluorescent and Surface-Enhanced Raman Scattering Nanoparticle and Nanostructured Systems
    MC Sardaru, NL Marangoci, R Palumbo, GN Roviello, A Rotaru
    Molecules 28 (8), 3561 2023

  • Synthesis and stability of zirconium and hafnium phthalocyanines with out-of-plane dopamine ligand
    N Fedosova, I Tretyakova, S Chernii, Y Gerasymchuk, R Bilyy, A Rotaru, ...
    Хімічні проблеми сьогодення, 39-39 2023

  • Self-assembled DNA nanostructures: principles and a rout to single-molecule level investigations
    A Rotaru
    Science and education: new approaches and perspectives, 6-6_2 2023

  • Nanotuburi de carbon cu un singur perete decorate cu nanoparticule de aur pentru aplicații n imagistica Raman a celulelor
    A Rotaru, V Ciornea
    Instruire prin cercetare pentru o societate prosperă, 259-261 2023

  • Synthesis and photophysical properties of indolenine styrylcyanine dye and its carboxyl-labeled derivative
    S Chernii, R Selin, I Tretyakova, Y Dovbiy, V Pekhnyo, A Rotaru, V Chernii, ...
    Biointerface Res. Appl. Chem 13, 2281-2287 2023

  • Dynameric G-quadruplex–dextran hydrogels for cell growth applications
    MC Sardaru, S Morariu, OE Carp, EL Ursu, A Rotaru, M Barboiu
    Chemical Communications 59 (21), 3134-3137 2023

  • Solid-Phase Synthesized Copolymers for the Assembly of pH-Sensitive Micelles Suitable for Drug Delivery Applications
    R Ghiarasim, CE Tiron, A Tiron, MG Dimofte, M Pinteala, A Rotaru
    Nanomaterials 12 (11), 1798 2022

  • Injectable Thixotropic β–Cyclodextrin–Functionalized Hydrogels Based on Guanosine Quartet Assembly
    MC Sardaru, I Rosca, S Morariu, EL Ursu, R Ghiarasim, A Rotaru
    International Journal of Molecular Sciences 22 (17), 9179 2021

  • Monomethine cyanine probes for visualization of cellular RNA by fluorescence microscopy
    D Aristova, V Kosach, S Chernii, Y Slominsky, A Balanda, V Filonenko, ...
    Methods and Applications in Fluorescence 9 (4), 045002 2021

  • Supramolecular Guanosine-Quadruplex Hydrogels and Hydrogel Composites for Cell Growth Applications
    EL Ursu, A Rotaru
    New Trends in Macromolecular and Supramolecular Chemistry for Biological 2021

  • Guanosine-Quadruplex
    EL Ursu, A Rotaru
    New Trends in Macromolecular and Supramolecular Chemistry for Biological 2021

  • New trends in macromolecular and Supramolecular chemistry for biological applications
    MJM Abadie, M Pinteala, A Rotaru
    Springer 2021

  • New 2, 9-disubstituted-1, 10-phenanthroline derivatives with anticancer activity by selective targeting of telomeric G-quadruplex DNA
    AM Craciun, A Rotaru, C Cojocaru, II Mangalagiu, R Danac
    Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 249, 119318 2021

  • Cyclodextrin encapsulated pH sensitive dyes as fluorescent cellular probes: self-aggregation and in vitro assessments
    MC Sardaru, O Carp, EL Ursu, AM Craciun, C Cojocaru, M Silion, ...
    Molecules 25 (19), 4397 2020

  • The use of C1 symmetry imidazole-carboxylate building block and auxiliary acetate co-ligand for assembly of a 2D wave-like zinc(II) coordination polymer
    D Bejan, LG Bahrin, C Cojocaru, AF Trandabat, NL Marangoci, A Rotaru, ...
    Journal of Coordination Chemistry 73 (16), 2250-2264 2020

MOST CITED SCHOLAR PUBLICATIONS

  • Single-molecule chemical reactions on DNA origami
    NV Voigt, T Trring, A Rotaru, MF Jacobsen, JB Ravnsbk, R Subramani, ...
    Nature nanotechnology 5 (3), 200-203 2010
    Citations: 615

  • Selective dsDNA‐templated formation of copper nanoparticles in solution
    A Rotaru, S Dutta, E Jentzsch, K Gothelf, A Mokhir
    Angewandte Chemie International Edition 49 (33), 5665-5667 2010
    Citations: 368

  • A novel coupling 1, 3‐dipolar cycloaddition sequence as a three‐component approach to highly fluorescent indolizines
    AV Rotaru, ID Druta, T Oeser, TJJ Mller
    Helvetica chimica acta 88 (7), 1798-1812 2005
    Citations: 123

  • Highly Selective Artificial Cholesteryl Crown Ether K+‐Channels
    Z Sun, M Barboiu, YM Legrand, E Petit, A Rotaru
    Angewandte Chemie International Edition 54 (48), 14473-14477 2015
    Citations: 94

  • Probing electron-induced bond cleavage at the single-molecule level using DNA origami templates
    A Keller, I Bald, A Rotaru, E Caut, KV Gothelf, F Besenbacher
    ACS nano 6 (5), 4392-4399 2012
    Citations: 83

  • Single molecule atomic force microscopy studies of photosensitized singlet oxygen behavior on a DNA origami template
    S Helmig, A Rotaru, D Arian, L Kovbasyuk, J Arnbjerg, PR Ogilby, J Kjems, ...
    ACS nano 4 (12), 7475-7480 2010
    Citations: 64

  • G-Quartet hydrogels for effective cell growth applications
    A Rotaru, G Pricope, TN Plank, L Clima, EL Ursu, M Pinteala, JT Davis, ...
    Chemical Communications 53 (94), 12668-12671 2017
    Citations: 57

  • Sequence dependence of electron-induced DNA strand breakage revealed by DNA nanoarrays
    A Keller, J Rackwitz, E Caut, J Livin, T Krzdrfer, A Rotaru, KV Gothelf, ...
    Scientific reports 4 (1), 7391 2014
    Citations: 57

  • Performances of clay aerogel polymer composites for oil spill sorption: Experimental design and modeling
    A Rotaru, C Cojocaru, I Cretescu, M Pinteala, D Timpu, L Sacarescu, ...
    Separation and Purification Technology 133, 260-275 2014
    Citations: 52

  • Dynamic constitutional frameworks for DNA biomimetic recognition
    R Catana, M Barboiu, I Moleavin, L Clima, A Rotaru, EL Ursu, M Pinteala
    Chemical Communications 51 (11), 2021-2024 2015
    Citations: 44

  • Nucleic acid binders activated by light of selectable wavelength
    A Rotaru, A Mokhir
    ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH- 46 (32), 6180 2007
    Citations: 41

  • A novel secondary DNA binding site in human topoisomerase I unravelled by using a 2D DNA origami platform
    R Subramani, S Juul, A Rotaru, FF Andersen, KV Gothelf, W Mamdouh, ...
    ACS nano 4 (10), 5969-5977 2010
    Citations: 40

  • Optimization of Polyplex Formation between DNA Oligonucleotide and Poly(l-Lysine): Experimental Study and Modeling Approach
    T Vasiliu, C Cojocaru, A Rotaru, G Pricope, M Pinteala, L Clima
    International journal of molecular sciences 18 (6), 1291 2017
    Citations: 30

  • Synthesis of novel phenanthroline derivatives by 3+ 2 dipolar cycloadition reaction
    R Danac, A Rotaru, G Drochioiu, I Druta
    Journal of heterocyclic chemistry 40 (2), 283-287 2003
    Citations: 28

  • Transfer of a protein pattern from self-assembled DNA origami to a functionalized substrate
    K Busuttil, A Rotaru, M Dong, F Besenbacher, KV Gothelf
    Chemical Communications 49 (19), 1927-1929 2013
    Citations: 27

  • DNA-assisted decoration of single-walled carbon nanotubes with gold nanoparticles for applications in surface-enhanced Raman scattering imaging of cells
    EL Ursu, F Doroftei, D Peptanariu, M Pinteala, A Rotaru
    Journal of Nanoparticle Research 19, 1-9 2017
    Citations: 25

  • Synthesis and properties of fluorescent 1, 3-substituted mono and biindolizines
    A Rotaru, I Druta, E Avram, R Danac
    Arkivoc 13, 287-299 2009
    Citations: 24

  • Monomethine cyanine probes for visualization of cellular RNA by fluorescence microscopy
    D Aristova, V Kosach, S Chernii, Y Slominsky, A Balanda, V Filonenko, ...
    Methods and Applications in Fluorescence 9 (4), 045002 2021
    Citations: 21

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