Alexandru Rotaru
@icmpp.ro
Scopus Publications
- Study of quantitative and qualitative changes in the composition of polysaccharides of Fomitopsis betulina at different stages of maturity of mushroom fruiting bodies
Lidiia Panchak, Semen Khomyak, Ivan Korabel, Alina Zyn, Olga R. Vrubel, et al.
Bioactive Carbohydrates and Dietary Fibre, 2026 - Dextran-driven hyperbranched black gold nanoparticles templated by guanosine quartets as broadband absorbers for photothermal therapy
Elena Laura Ursu, Monica Cornelia Sardaru, Cristian Ursu, Adina Arvinte, Dragos Peptanariu, et al.
International Journal of Biological Macromolecules, 2026 - Polyethyleneimine-Directed In Situ Gold Deposition on Gallium Nitride Nanoparticles for Enhanced Electrochemical Detection of Erythromycin
Oana Elena Carp, Denisse-Iulia Bostiog, Elena Laura Ursu, Rares-Georgian Mocanu, Narcisa Laura Marangoci, et al.
International Journal of Molecular Sciences, 2026
Hybrid nanomaterials that integrate surface functionality, colloidal stability, and efficient electron-transfer pathways are highly attractive for improving electrochemical sensing performance. Herein, we report the fabrication and evaluation of polyethyleneimine-functionalized gallium nitride nanoparticles (GaN) decorated with gold nanoparticles (GaN-PEI-Au) as a tunable electrode modifier for enhanced differential pulse voltammetry (DPV) detection of erythromycin. Branched polyethyleneimine was employed as a multifunctional interfacial layer to stabilize GaN dispersions, introduce amine-rich surface chemistry, and enable in situ gold nanoparticle formation at the GaN-PEI. The optimized GaN-PEI-Au material exhibited high colloidal stability, a characteristic Au localized surface plasmon resonance in the ~520–525 nm range, and well-defined Au nanoparticles attached to the GaN surface. When applied as an electrode coating, GaN-PEI-Au significantly enhanced the erythromycin oxidation response compared to bare Au and GaN-PEI interfaces, consistent with synergistic increases in electroactive surface area and interfacial charge-transfer efficiency. Under optimized DPV conditions, GaN-PEI-Au-modified electrodes enabled quantitative erythromycin determination with a linear range of 5 nM–2 µM (R2 = 0.990), sensitivity of 1.32 × 10−3 µA nM−1, and a limit of detection of 52.5 nM, while maintaining stable baseline behavior during repeated scans. The reported GaN-PEI-Au nanocomposites represent a robust platform for sensitive electrochemical detection of pharmaceutical compounds. - Evaluation of HER2 Targeted Poly(Ethylene Glycol)-Poly(L-histidine) Copolymer Micelles in Breast Cancer Models
Remya Valsala Kumari, Abhilash D. Pandya, Solveig J. Pettersen, Audun Kvalvaag, Anne Grethe Myrann, et al.
Macromolecular Bioscience, 2025
Breast cancer positive for human epidermal growth factor receptor‐2 (HER2) is challenging to treat due to the development of drug resistance, even with recently developed antibody‐mediated therapeutics. However, nanotechnology provides new innovative therapeutic strategies. This study evaluates the efficacy of new HER2‐targeted, pH‐sensitive poly(ethylene glycol)‐poly(L‐histidine) copolymer micelles (PEG‐PHis micelles), either empty, loaded with the drug doxorubicin (DOX), or the fluorophore Rhodamine‐B (RB) for imaging purposes. Cellular association of the micelles, in vitro effects on proliferation and cytotoxicity, as well as ex vivo and in vivo responses on tumor growth are assessed. The results indicate that trastuzumab (TZM) conjugation enhances the specific cellular association of PEG‐PHis micelles in HER2 overexpressing cells and improves the cytotoxic effects of the micelles themselves. Although the TZM conjugation of DOX‐loaded micelles did not contribute to an enhancement in overall efficacy in cell lines and tumor explant cultures, the findings highlight the potential of TZM conjugation on these micelles in targeting HER2‐positive tumors. - Assembly and stability of trastuzumab-conjugated and unmodified poly(L-histidine)-poly(ethylene glycol) micelles for targeting HER2-positive cells
Razvan Ghiarasim, Gabriel Luta, Mihail-Gabriel Dimofte, Tore-Geir Iversen, Mariana Pinteala, et al.
Journal of Molecular Liquids, 2025 - Synergistic Antibacterial Action of Norfloxacin-Encapsulated G4 Hydrogels: The Role of Boronic Acid and Cyclodextrin
Monica-Cornelia Sardaru, Irina Rosca, Simona Morariu, Elena-Laura Ursu, Alexandru Rotaru
Gels, 2025
In this present study, we developed and characterized a series of supramolecular G4 hydrogels by integrating β-cyclodextrin (β-CD) and boronic acid linkers into a supramolecular matrix to enhance antibacterial activity against Staphylococcus aureus (S. aureus). We systematically investigated how varying the number of free boronic acid moieties (ranging from two to six), along with guanosine and β-CD content, influences both the structural integrity and antimicrobial efficacy of these materials. Comprehensive characterization using FTIR, circular dichroism, X-ray diffraction, SEM, AFM, and rheological measurements confirmed successful synthesis and revealed that higher boronic acid content correlated with a stronger, more organized network. The most effective hydrogel displayed an inhibition zone of 25 mm in disk diffusion assays, and was further explored as a drug delivery platform, with the aim to exploit the capacity of the free β-CD cavity of the hydrogels to incorporate hydrophobic drugs. Norfloxacin (Nfx), a poorly water-soluble antibiotic, was successfully encapsulated within the hydrogel matrix through the inclusion of complex formation with β-CD, improving its solubility and enabling sustained, targeted release. The Nfx-loaded hydrogel expanded the inhibition zone to 49 mm and completely eradicated S. aureus cells within 24 h, outperforming both the unloaded hydrogel and free Nfx. These results highlight the synergistic effect of boronic acid moieties and controlled drug release, underlining the potential of these hydrogels as versatile platforms for localized antimicrobial therapy, such as in wound dressings or implant coatings. Nevertheless, further in vivo studies and long-term stability assessments are needed to fully establish clinical relevance, safety, and scalability before these systems can be translated into routine healthcare applications. - Photothermal Hydrogel Composites Featuring G4-Carbon Nanomaterial Networks for Staphylococcus aureus Inhibition
Monica-Cornelia Sardaru, Irina Rosca, Cristian Ursu, Ioan-Andrei Dascalu, Elena-Laura Ursu, et al.
ACS Omega, 2024 - Synthesis and photophysical properties of indolenine styrylcyanine dye and its carboxyl-labeled derivative
Biointerface Research in Applied Chemistry, 2023 - 3D-Shaped Binders of Unfolded Proteins Inducing Cancer Cell-Specific Endoplasmic Reticulum Stress In Vitro and In Vivo
Insa Klemt, Oleg Varzatskii, Roman Selin, Serhii Vakarov, Vladyslava Kovalska, et al.
Journal of the American Chemical Society, 2023
The amount of unfolded proteins is increased in cancer cells, leading to endoplasmic reticulum (ER) stress. Therefore, cancer cells are sensitive to drugs capable of further enhancing ER stress. Examples of such drugs include the clinically approved proteosome inhibitors bortezomib and carfilzomib. Unfortunately, the known ER stress inducers exhibit dose-limiting side effects that justify the search for better, more cancer-specific drugs of this type. Herein, we report on FeC 2, which binds to unfolded proteins prevents their further processing, thereby leading to ER stress and ROS increase in cancer cells, but not in normal cells. FeC 2 exhibits low micromolar toxicity toward human acute promyelocytic leukemia HL-60, Burkitt's lymphoma BL-2, T-cell leukemia Jurkat, ovarian carcinoma A2780, lung cancer SK-MES-1, and murine lung cancer LLC1 cells. Due to the cancer-specific mode of action, 2 is not toxic in vivo up to the dose of 147 mg/kg, does not affect normal blood and bone marrow cells at the therapeutically active dose, but strongly suppresses both primary tumor growth (confirmed in Nemeth-Kellner lymphoma and LLC1 lung cancer models of murine tumor) and spreading of metastases (LLC1). - Nucleic Acid Probes in Bio-Imaging and Diagnostics: Recent Advances in ODN-Based Fluorescent and Surface-Enhanced Raman Scattering Nanoparticle and Nanostructured Systems
Monica-Cornelia Sardaru, Narcisa-Laura Marangoci, Rosanna Palumbo, Giovanni N. Roviello, Alexandru Rotaru
Molecules, 2023
Raman nanoparticle probes are a potent class of optical labels for the interrogation of pathological and physiological processes in cells, bioassays, and tissues. Herein, we review the recent advancements in fluorescent and Raman imaging using oligodeoxyribonucleotide (ODN)-based nanoparticles and nanostructures, which show promise as effective tools for live-cell analysis. These nanodevices can be used to investigate a vast number of biological processes occurring at various levels, starting from those involving organelles, cells, tissues, and whole living organisms. ODN-based fluorescent and Raman probes have contributed to the achievement of significant advancements in the comprehension of the role played by specific analytes in pathological processes and have inaugurated new possibilities for diagnosing health conditions. The technological implications that have emerged from the studies herein described could open new avenues for innovative diagnostics aimed at identifying socially relevant diseases like cancer through the utilization of intracellular markers and/or guide surgical procedures based on fluorescent or Raman imaging. Particularly complex probe structures have been developed within the past five years, creating a versatile toolbox for live-cell analysis, with each tool possessing its own strengths and limitations for specific studies. Analyzing the literature reports in the field, we predict that the development of ODN-based fluorescent and Raman probes will continue in the near future, disclosing novel ideas on their application in therapeutic and diagnostic strategies. - Dynameric G-quadruplex-dextran hydrogels for cell growth applications
Monica-Cornelia Sardaru, Simona Morariu, Oana-Elena Carp, Elena-Laura Ursu, Alexandru Rotaru, et al.
Chemical Communications, 2023 - Solid-Phase Synthesized Copolymers for the Assembly of pH-Sensitive Micelles Suitable for Drug Delivery Applications
Razvan Ghiarasim, Crina Elena Tiron, Adrian Tiron, Mihail-Gabriel Dimofte, Mariana Pinteala, et al.
Nanomaterials, 2022 - Monomethine cyanine probes for visualization of cellular RNA by fluorescence microscopy
Daria Aristova, Viktoriia Kosach, Svitlana Chernii, Yuriy Slominsky, Anatoliy Balanda, et al.
Methods and Applications in Fluorescence, 2021 - Injectable thixotropic β–cyclodextrin–functionalized hydrogels based on guanosine quartet assembly
Monica-Cornelia Sardaru, Irina Rosca, Simona Morariu, Elena-Laura Ursu, Razvan Ghiarasim, et al.
International Journal of Molecular Sciences, 2021 - Supramolecular guanosine-quadruplex hydrogels and hydrogel composites for cell growth applications
Elena Laura Ursu, Alexandru Rotaru
New Trends in Macromolecular and Supramolecular Chemistry for Biological Applications, 2021 - New trends in macromolecular and supramolecular chemistry for biological applications
New Trends in Macromolecular and Supramolecular Chemistry for Biological Applications, 2021 - New 2,9-disubstituted-1,10-phenanthroline derivatives with anticancer activity by selective targeting of telomeric G-quadruplex DNA
Anda-Mihaela Craciun, Alexandru Rotaru, Corneliu Cojocaru, Ionel I. Mangalagiu, Ramona Danac
Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy, 2021 - Cyclodextrin encapsulated pH sensitive dyes as fluorescent cellular probes: Self-aggregation and in vitro assessments
Monica-Cornelia Sardaru, Oana Carp, Elena-Laura Ursu, Anda-Mihaela Craciun, Corneliu Cojocaru, et al.
Molecules, 2020 - The use of C1 symmetry imidazole-carboxylate building block and auxiliary acetate co-ligand for assembly of a 2D wave-like zinc(II) coordination polymer: experimental and theoretical study
Dana Bejan, Lucian Gabriel Bahrin, Corneliu Cojocaru, Alexandru Florentin Trandabat, Narcisa Laura Marangoci, et al.
Journal of Coordination Chemistry, 2020 - Single-walled carbon nanotubes–G-quadruple hydrogel nanocomposite matrixes for cell support applications
Elena-Laura Ursu, Gabriela Gavril, Simona Morariu, Mariana Pinteala, Mihail Barboiu, et al.
Materials Science and Engineering C, 2020 - 2,4,6-Tris(4-Iodophenyl)-1,3,5-Trimethylbenzene
Dana Bejan, Narcisa Laura Marangoci, Alexandru Rotaru, Alexandru Florentin Trandabat, Lucian Gabriel Bahrin
Molbank, 2020 - Photophysics of poly(3,4-ethylenedioxythiophene) covered by permodified γ-cyclodextrin
Ana-Maria Resmerita, Aurelian D. Costea, Flavian Farcas, Angela Rotaru, Aurica Farcaș
Proceedings of SPIE the International Society for Optical Engineering, 2020 - Synthesis, structure, computational modeling, and biological activity of two novel bimesitylene derivatives
Lucian G. Bahrin, Lilia Clima, Sergiu Shova, Irina Rosca, Corneliu Cojocaru, et al.
Research on Chemical Intermediates, 2019 - Mass Spectrometry as a Complementary Approach for Noncovalently Bound Complexes Based on Cyclodextrins
Mihaela Silion, Adrian Fifere, Ana Lacramioara Lungoci, Narcisa Laura Marangoci, Sorin Alexandru Ibanescu, et al.
Advances in Experimental Medicine and Biology, 2019 - Zinc(II) coordination polymer on the base of 3′-(1H-tetrazol-5-yl)-[1,1′-biphenyl]-4-carboxylic acid: Synthesis, crystal structure and antimicrobial properties
Lucian G. Bahrin, Irina Rosca, Lilia Clima, Sergiu Shova, Dana Bejan, et al.
Inorganic Chemistry Communications, 2018 - Polyplex formation between cyclodextrin-based non-viral vector and dsdna: Molecular dynamic study with experimental validation
Revue Roumaine De Chimie, 2018 - The effect of the macrocyclic encapsulation on the photophysical properties of conjugated polymers
Aurica Farcas, Mihaela Balan-Porcarasu, Ana-Maria Resmerita, Mihai Asandulesa, Angela Rotaru, et al.
Proceedings of SPIE the International Society for Optical Engineering, 2018 - Novel cyclodextrin-based pH-sensitive supramolecular host-guest assembly for staining acidic cellular organelles
Gabriela Pricope, Elena Laura Ursu, Monica Sardaru, Corneliu Cojocaru, Lilia Clima, et al.
Polymer Chemistry, 2018 - Optimization of polyplex formation between DNA oligonucleotide and poly(L-Lysine): Experimental study and modeling approach
Tudor Vasiliu, Corneliu Cojocaru, Alexandru Rotaru, Gabriela Pricope, Mariana Pinteala, et al.
International Journal of Molecular Sciences, 2017 - DNA-assisted decoration of single-walled carbon nanotubes with gold nanoparticles for applications in surface-enhanced Raman scattering imaging of cells
Elena-Laura Ursu, Florica Doroftei, Dragos Peptanariu, Mariana Pinteala, Alexandru Rotaru
Journal of Nanoparticle Research, 2017 - G-Quartet hydrogels for effective cell growth applications
Alexandru Rotaru, Gabriela Pricope, Taylor N. Plank, Lilia Clima, Elena L. Ursu, et al.
Chemical Communications, 2017 - Supramolecular rulers enabling selective detection of pure short ssDNA via chiral self-assembly
Istvan Kocsis, Alexandru Rotaru, Yves-Marie Legrand, Ion Grosu, Mihail Barboiu
Chemical Communications, 2016 - Synthesis and photophysics of conjugated azomethine polyrotaxanes
A.-M. Resmerita, F. Farcas, A. Rotaru, A. Farcas
Proceedings of SPIE the International Society for Optical Engineering, 2016 - Pyridyl-indolizine derivatives as DNA binders and pH-sensitive fluorescent dyes
Narcisa-Laura Marangoci, Lacramioara Popovici, Elena-Laura Ursu, Ramona Danac, Lilia Clima, et al.
Tetrahedron, 2016 - Highly Selective Artificial Cholesteryl Crown Ether K+-Channels
Zhanhu Sun, Mihail Barboiu, Yves‐Marie Legrand, Eddy Petit, Alexandru Rotaru
Angewandte Chemie International Edition, 2015 - DNA-mediated copper nanoparticle formation on dispersed single-walled carbon nanotubes
Elena‐Laura Ursu, Lilia Clima, Christian Hejesen, Alexandru Rotaru, Mariana Pinteala
Helvetica Chimica Acta, 2015 - Experimental design, modeling and optimization of polyplex formation between DNA oligonucleotides and branched polyethylenimine
Lilia Clima, Elena L. Ursu, Corneliu Cojocaru, Alexandru Rotaru, Mihail Barboiu, et al.
Organic and Biomolecular Chemistry, 2015 - Dynamic constitutional frameworks for DNA biomimetic recognition
Romina Catana, Mihail Barboiu, Ioana Moleavin, Lilia Clima, Alexandru Rotaru, et al.
Chemical Communications, 2015 - Performances of clay aerogel polymer composites for oil spill sorption: Experimental design and modeling
Alexandru Rotaru, Corneliu Cojocaru, Igor Cretescu, Mariana Pinteala, Daniel Timpu, et al.
Separation and Purification Technology, 2014 - Sequence dependence of electron-induced DNA strand breakage revealed by DNA nanoarrays
Adrian Keller, Jenny Rackwitz, Emilie Cauët, Jacques Liévin, Thomas Körzdörfer, et al.
Scientific Reports, 2014 - Molecular structure and electronic properties of pyridylindolizine derivative containing phenyl and phenacyl groups: Comparison between semi-empirical calculations and experimental studies
Corneliu Cojocaru, Alexandru Rotaru, Valeria Harabagiu, Liviu Sacarescu
Journal of Molecular Structure, 2013 - Transfer of a protein pattern from self-assembled DNA origami to a functionalized substrate
Katerina Busuttil, Alexandru Rotaru, Mingdong Dong, Flemming Besenbacher, Kurt V. Gothelf
Chemical Communications, 2013 - New conjugates of calix[4]arenes bearing dipyridine and indolizine heterocycles
Ramona Danac, Raluca Rusu, Alexandru Rotaru, Aurel Pui, Sergiu Shova
Supramolecular Chemistry, 2012 - Probing electron-induced bond cleavage at the single-molecule level using DNA origami templates
Adrian Keller, Ilko Bald, Alexandru Rotaru, Emilie Cauët, Kurt V. Gothelf, et al.
ACS Nano, 2012 - Single molecule atomic force microscopy studies of photosensitized singlet oxygen behavior on a DNA origami template
Sarah Helmig, Alexandru Rotaru, Dumitru Arian, Larisa Kovbasyuk, Jacob Arnbjerg, et al.
ACS Nano, 2010 - A novel secondary DNA binding site in human topoisomerase i unravelled by using a 2D DNA origami platform
Ramesh Subramani, Sissel Juul, Alexandru Rotaru, Felicie F. Andersen, Kurt V. Gothelf, et al.
ACS Nano, 2010 - Selective dsDNA-templated formation of copper nanoparticles in solution
Alexandru Rotaru, Subrata Dutta, Elmar Jentzsch, Kurt Gothelf, Andriy Mokhir
Angewandte Chemie International Edition, 2010 - DNA nanotechnology: Steps towards automated synthesis
Alexandru Rotaru, Kurt V. Gothelf
Nature Nanotechnology, 2010 - Single-molecule chemical reactions on DNA origami
Niels V. Voigt, Thomas Tørring, Alexandru Rotaru, Mikkel F. Jacobsen, Jens B. Ravnsbæk, et al.
Nature Nanotechnology, 2010 - Synthesis and properties of fluorescent 1,3-substituted mono and biindolizines
Ramona Danac, Alexandru Rotaru, Ioan Druta, Ecaterina Avram
Arkivoc, 2009 - Red light-activated phosphorothioate oligodeoxyribonucleotides
Alexandru Rotaru, János Kovács, Andriy Mokhir
Bioorganic and Medicinal Chemistry Letters, 2008 - Nucleic acid binders activated by light of selectable wavelength
Alexandru Rotaru, Andriy Mokhir
Angewandte Chemie International Edition, 2007 - A novel coupling 1,3-dipolar cycloaddition sequence as a three-component approach to highly fluorescent indolizines
Alexandru V. Rotaru, Ioan D. Druta, Thomas Oeser, Thomas J. J. Müller
Helvetica Chimica Acta, 2005 - Sinteza şi activitatea biologicǎ a sǎrurilor dicuaternare derivate de la 4,4′-bipiridil
Revista De Chimie, 2005 - Study of dipolar 3+2 cycloaddition reaction of 1,10-phenanthrolinium ylides to activated alkenes
Revista De Chimie, 2005 - Synthesis of new non-symmetrical substituted 7,7′-bisindolizines by the direct reaction of 4,4′-bipyridinium-ylides with dimethyl acetylenedicarboxylate
Alexandru V. Rotaru, Ramona P. Danac, Ioan D. Druta
Journal of Heterocyclic Chemistry, 2004 - Antimicrobial activity of new 4,4′-bipyridine derivatives: And in vitro study
A. Rotaru, M. Ungureanu, R. Danac, A. Poeata, I. Druta
Annales Pharmaceutiques Francaises, 2004 - Synthesis of novel 4,5-diazafluoren-9-one derivatives and theoretical study of 3+2 cycloaddition reactions
Ramona Danac, Ioan Druta, Alexandru Rotaru, Constantin Ghirvu, Mircea Constantinescu
Journal of Heterocyclic Chemistry, 2004 - Synthesis of novel phenanthroline derivatives by 3+2 dipolar cycloadition reaction
Ramona Danac, Alexandra Rotaru, Gabi Drochioiu, Ioan Druta
Journal of Heterocyclic Chemistry, 2003
RECENT SCHOLAR PUBLICATIONS
- Dextran-driven hyperbranched black gold nanoparticles templated by guanosine quartets as broadband absorbers for photothermal therapy
EL Ursu, MC Sardaru, C Ursu, A Arvinte, D Peptanariu, R Bilyy, G Bila, ...
International Journal of Biological Macromolecules, 152191 , 2026
2026 - Polyethyleneimine-Directed In Situ Gold Deposition on Gallium Nitride Nanoparticles for Enhanced Electrochemical Detection of Erythromycin
OE Carp, DI Bostiog, EL Ursu, RG Mocanu, NL Marangoci, I Tiginyanu, ...
International Journal of Molecular Sciences 27 (6), 2728 , 2026
2026 - Evaluation of HER2 Targeted Poly(Ethylene Glycol)‐Poly( L ‐histidine) Copolymer Micelles in Breast Cancer Models
R Valsala Kumari, AD Pandya, SJ Pettersen, A Kvalvaag, AG Myrann, ...
Macromolecular Bioscience 25 (11), e00047 , 2025
2025
Citations: 2 - Assembly and stability of trastuzumab-conjugated and unmodified poly (L-histidine)-poly (ethylene glycol) micelles for targeting HER2-positive cells
R Ghiarasim, G Luta, MG Dimofte, TG Iversen, M Pinteala, A Rotaru
Journal of Molecular Liquids 418, 126689 , 2025
2025
Citations: 5 - Synergistic Antibacterial Action of Norfloxacin-Encapsulated G4 Hydrogels: The Role of Boronic Acid and Cyclodextrin
MC Sardaru, I Rosca, S Morariu, EL Ursu, A Rotaru
Gels 11 (1), 35 , 2025
2025
Citations: 3 - Supramolecular G4 Hydrogel Systems for Cell Support and Antimicrobial Applications
A Rotaru
Nanotechnologies and Biomedical Engineering, 88-88 , 2025
2025 - Preparation of Dextran–Guanosine–Gold Hybrid Magnetic Nanoparticles as Substrates for Surface-Enhanced Raman Scattering
T Dulgheriu, EL Ursu, R Ghiarasim, A Rotaru, NL Marangoci, I Tiginyanu, ...
Nanotechnologies and Biomedical Engineering, 77-78 , 2025
2025 - Photothermal Hydrogel Composites Featuring G4-Carbon Nanomaterial Networks for Staphylococcus aureus Inhibition
MC Sardaru, I Rosca, C Ursu, IA Dascalu, EL Ursu, S Morariu, A Rotaru
ACS omega 9 (14), 15833-15844 , 2024
2024
Citations: 7 - Antimicrobial, antiproliferative and dna-interacting properties of 6-(2, 4-dichlorobenzoyl)-7-(2, 4-dichlorophenyl) indolo [3, 4-jk] phenanthridin-5 (4h)-one
E Gorincioi, V Pogrebnoi, D Iunac, G Balan, AV Rotaru, N Sucman, ...
Materials Science and Condensed Matter Physics, 107-107 , 2024
2024 - 3D-shaped binders of unfolded proteins inducing cancer cell-specific endoplasmic reticulum stress in vitro and in vivo
I Klemt, O Varzatskii, R Selin, S Vakarov, V Kovalska, G Bila, R Bilyy, ...
Journal of the American Chemical Society 145 (40), 22252-22264 , 2023
2023
Citations: 17 - Nucleic acid probes in bio-imaging and diagnostics: recent advances in ODN-based fluorescent and surface-enhanced Raman scattering nanoparticle and nanostructured systems
MC Sardaru, NL Marangoci, R Palumbo, GN Roviello, A Rotaru
Molecules 28 (8), 3561 , 2023
2023
Citations: 6 - Synthesis and stability of zirconium and hafnium phthalocyanines with out-of-plane dopamine ligand
N Fedosova, I Tretyakova, S Chernii, Y Gerasymchuk, R Bilyy, A Rotaru, ...
Хімічні проблеми сьогодення, 39-39 , 2023
2023 - Self-assembled DNA nanostructures: principles and a rout to single-molecule level investigations
A Rotaru
Science and education: new approaches and perspectives, 6-6_2 , 2023
2023 - Nanotuburi de carbon cu un singur perete decorate cu nanoparticule de aur pentru aplicații în imagistica Raman a celulelor
A Rotaru, V Ciornea
Instruire prin cercetare pentru o societate prosperă, 259-261 , 2023
2023 - Synthesis and photophysical properties of indolenine styrylcyanine dye and its carboxyl-labeled derivative
S Chernii, R Selin, I Tretyakova, Y Dovbiy, V Pekhnyo, A Rotaru, V Chernii, ...
Biointerface Res. Appl. Chem 13, 2281-2287 , 2023
2023
Citations: 1 - Dynameric G-quadruplex–dextran hydrogels for cell growth applications
MC Sardaru, S Morariu, OE Carp, EL Ursu, A Rotaru, M Barboiu
Chemical Communications 59 (21), 3134-3137 , 2023
2023
Citations: 8 - Solid-Phase Synthesized Copolymers for the Assembly of pH-Sensitive Micelles Suitable for Drug Delivery Applications
R Ghiarasim, CE Tiron, A Tiron, MG Dimofte, M Pinteala, A Rotaru
Nanomaterials 12 (11), 1798 , 2022
2022
Citations: 6 - Monomethine cyanine probes for visualization of cellular RNA by fluorescence microscopy
D Aristova, V Kosach, S Chernii, Y Slominsky, A Balanda, V Filonenko, ...
Methods and Applications in Fluorescence 9 (4), 045002 , 2021
2021
Citations: 24 - Injectable thixotropic β–cyclodextrin–functionalized hydrogels based on guanosine quartet assembly
MC Sardaru, I Rosca, S Morariu, EL Ursu, R Ghiarasim, A Rotaru
International Journal of Molecular Sciences 22 (17), 9179 , 2021
2021
Citations: 9 - Supramolecular Guanosine-Quadruplex Hydrogels and Hydrogel Composites for Cell Growth Applications
EL Ursu, A Rotaru
New Trends in Macromolecular and Supramolecular Chemistry for Biological … , 2021
2021
Citations: 2
MOST CITED SCHOLAR PUBLICATIONS
- Single-molecule chemical reactions on DNA origami
NV Voigt, T Tørring, A Rotaru, MF Jacobsen, JB Ravnsbæk, R Subramani, ...
Nature nanotechnology 5 (3), 200-203 , 2010
2010
Citations: 635 - Selective dsDNA‐templated formation of copper nanoparticles in solution
A Rotaru, S Dutta, E Jentzsch, K Gothelf, A Mokhir
Angewandte Chemie International Edition 49 (33), 5665-5667 , 2010
2010
Citations: 385 - A novel coupling 1, 3‐dipolar cycloaddition sequence as a three‐component approach to highly fluorescent indolizines
AV Rotaru, ID Druta, T Oeser, TJJ Müller
Helvetica chimica acta 88 (7), 1798-1812 , 2005
2005
Citations: 122 - Highly Selective Artificial Cholesteryl Crown Ether K + ‐Channels
Z Sun, M Barboiu, YM Legrand, E Petit, A Rotaru
Angewandte Chemie International Edition 54 (48), 14473-14477 , 2015
2015
Citations: 108 - Probing electron-induced bond cleavage at the single-molecule level using DNA origami templates
A Keller, I Bald, A Rotaru, E Cauet, KV Gothelf, F Besenbacher
ACS nano 6 (5), 4392-4399 , 2012
2012
Citations: 89 - Single molecule atomic force microscopy studies of photosensitized singlet oxygen behavior on a DNA origami template
S Helmig, A Rotaru, D Arian, L Kovbasyuk, J Arnbjerg, PR Ogilby, J Kjems, ...
ACS nano 4 (12), 7475-7480 , 2010
2010
Citations: 68 - G-Quartet hydrogels for effective cell growth applications
A Rotaru, G Pricope, TN Plank, L Clima, EL Ursu, M Pinteala, JT Davis, ...
Chemical Communications 53 (94), 12668-12671 , 2017
2017
Citations: 61 - Performances of clay aerogel polymer composites for oil spill sorption: Experimental design and modeling
A Rotaru, C Cojocaru, I Cretescu, M Pinteala, D Timpu, L Sacarescu, ...
Separation and Purification Technology 133, 260-275 , 2014
2014
Citations: 58 - Sequence dependence of electron-induced DNA strand breakage revealed by DNA nanoarrays
A Keller, J Rackwitz, E Cauët, J Liévin, T Körzdörfer, A Rotaru, KV Gothelf, ...
Scientific reports 4 (1), 7391 , 2014
2014
Citations: 57 - Dynamic constitutional frameworks for DNA biomimetic recognition
R Catana, M Barboiu, I Moleavin, L Clima, A Rotaru, EL Ursu, M Pinteala
Chemical Communications 51 (11), 2021-2024 , 2015
2015
Citations: 47 - A novel secondary DNA binding site in human topoisomerase I unravelled by using a 2D DNA origami platform
R Subramani, S Juul, A Rotaru, FF Andersen, KV Gothelf, W Mamdouh, ...
ACS nano 4 (10), 5969-5977 , 2010
2010
Citations: 41 - Nucleic acid binders activated by light of selectable wavelength
A Rotaru, A Mokhir
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH- 46 (32), 6180 , 2007
2007
Citations: 41 - Optimization of Polyplex Formation between DNA Oligonucleotide and Poly( l -Lysine): Experimental Study and Modeling Approach
T Vasiliu, C Cojocaru, A Rotaru, G Pricope, M Pinteala, L Clima
International journal of molecular sciences 18 (6), 1291 , 2017
2017
Citations: 35 - Transfer of a protein pattern from self-assembled DNA origami to a functionalized substrate
K Busuttil, A Rotaru, M Dong, F Besenbacher, KV Gothelf
Chemical Communications 49 (19), 1927-1929 , 2013
2013
Citations: 29 - Synthesis of novel phenanthroline derivatives by 3+ 2 dipolar cycloadition reaction
R Danac, A Rotaru, G Drochioiu, I Druta
Journal of heterocyclic chemistry 40 (2), 283-287 , 2003
2003
Citations: 28 - DNA-assisted decoration of single-walled carbon nanotubes with gold nanoparticles for applications in surface-enhanced Raman scattering imaging of cells
EL Ursu, F Doroftei, D Peptanariu, M Pinteala, A Rotaru
Journal of Nanoparticle Research 19 (5), 181 , 2017
2017
Citations: 26 - Synthesis and properties of fluorescent 1, 3-substituted mono and biindolizines
A Rotaru, I Druta, E Avram, R Danac
Arkivoc 13, 287-299 , 2009
2009
Citations: 26 - Monomethine cyanine probes for visualization of cellular RNA by fluorescence microscopy
D Aristova, V Kosach, S Chernii, Y Slominsky, A Balanda, V Filonenko, ...
Methods and Applications in Fluorescence 9 (4), 045002 , 2021
2021
Citations: 24 - Novel cyclodextrin-based pH-sensitive supramolecular host–guest assembly for staining acidic cellular organelles
G Pricope, EL Ursu, M Sardaru, C Cojocaru, L Clima, N Marangoci, ...
Polymer Chemistry 9 (8), 968-975 , 2018
2018
Citations: 20 - Pyridyl-indolizine derivatives as DNA binders and pH-sensitive fluorescent dyes
NL Marangoci, L Popovici, EL Ursu, R Danac, L Clima, C Cojocaru, ...
Tetrahedron 72 (50), 8215-8222 , 2016
2016
Citations: 20
