PHD IN MEDICAL SCIENCES, University of Malaya (UM), Malaysia
Bachelor Of Science (Microbiology), University Putra Malaysia, Malaysia
Good Clinical Practice, University of Malaya, Malaysia
Insights Into Brain Networks Driving Optimal Flow and the Role of Mindfulness in Flow Rathi Priya Bollu Yashwant, Eng Hwa Wong Psychology of Optimal States, 2025 Flow is a mental state of complete absorption into the present task with a strong drive and diminished sense of self and time. Optimal flow is a state of peak performance where individuals engage in any highly-skilled activity task with complete focus, efficiency, and immersion. However, the neural dynamics and systems involved in the flow and optimal flow states are complex and require significant scientific interdisciplinary scrutiny. Mindfulness is a mental state of being fully present and engaged in the current moment, without judgment. Mindfulness and flow share commonalities, as both involve deep focus and immersion in the present moment. Long-term mindfulness practices may enhance one's ability to be in flow state for longer durations, mainly by altering the neuroplasticity in the brain areas associated with emotional and cognitive health. Henceforth, in this chapter, the Authors have outlined the main neural correlates of the flow and optimal flow states as well as the impact of mindfulness in achieving these states.
The Impact of Neuroplasticity on Skill Acquisition and Cognitive Growth Rathi Priya Bollu Yashwant, Eng Hwa Wong Impact of Neuroplasticity on Organizational Effectiveness and Labor Productivity, 2025 This chapter explores the foundational role of neuroplasticity in skill acquisition and cognitive growth across the human lifespan. Neuroplasticity—the brain's ability to reorganize its structure and function in response to internal and external stimuli—underpins the development of new skills, adaptation to environmental demands, and recovery from injury. Drawing on recent advances in neuroscience, the chapter examines key mechanisms of plasticity, including synaptic strengthening, dendritic remodeling, and network-level reorganization, and links these to practical outcomes in education, professional development, and rehabilitation.The chapter also addresses neuroplasticity in neurodiverse populations and clinical conditions, highlighting both the potential and limitations of plastic change. By integrating empirical findings with applied frameworks, this work provides a multidimensional understanding of how neuroplasticity can be harnessed to foster learning, improve cognitive performance, and promote lifelong adaptability.
In vitro antifungal and oxidative stress evaluation of silver nanoparticles stabilised with gum arabic protein on Candida glabrata (Nakaseomyces glabratus) strains Malaysian Journal of Microbiology, 2025
1H NMR metabolomics insights into comparative diabesity in male and female zebrafish and the antidiabetic activity of DL-limonene Khaled Benchoula, Christopher J. Serpell, Ahmed Mediani, Abdulaziz Albogami, Norazlan Mohmad Misnan, et al. Scientific Reports, 2024 Zebrafish have been utilized for many years as a model animal for pharmacological studies on diabetes and obesity. High-fat diet (HFD), streptozotocin and alloxan injection, and glucose immersion have all been used to induce diabetes and obesity in zebrafish. Currently, studies commonly used both male and female zebrafish, which may influence the outcomes since male and female zebrafish are biologically different. This study was designed to investigate the difference between the metabolites of male and female diabetic zebrafish, using limonene – a natural product which has shown several promising results in vitro and in vivo in treating diabetes and obesity—and provide new insights into how endogenous metabolites change following limonene treatment. Using HFD-fed male and female zebrafish, we were able to develop an animal model of T2D and identify several endogenous metabolites that might be used as diagnostic biomarkers for diabetes. The endogenous metabolites in males and females were different, even though both genders had high blood glucose levels and a high BMI. Treatment with limonene prevented high blood glucose levels and improved in diabesity zebrafish by limonene, through reversal of the metabolic changes caused by HFD in both genders. In addition, limonene was able to reverse the elevated expression of AKT during HFD.
The effects of school-based hygiene intervention programme: Systematic review and meta-analysis Sophia Rasheeqa Ismail, Ranina Radzi, Puteri Sofia Nadira Megat Kamaruddin, Ezarul Faradianna Lokman, Han Yin Lim, et al. Plos One, 2024 Children are susceptible to infections due to frequent participation in school group activities and their often-suboptimal hygiene practices. Frequent infections in children affect school attendance, academic performances, and general health. The effectiveness of school-based hygiene-related intervention programmes need to be informed by updated high-quality synthesised evidence. In this systematic review, we searched PubMed and Cochrane CENTRAL for randomised and non-randomised interventional studies that evaluated school-based hygiene-related interventions. We assessed risk-of-bias (Cochrane risk-of-bias 2 tool), performed random-effect meta-analysis (RevMan 5.4) and rated certainty-of-evidence (GRADE). Thirty-nine trials (41 reports), published from 2011 to 2024 from 22 countries were included. Twenty-three studies contributed data for meta-analysis. All school-based interventions were compared with standard curriculum and demonstrated very low to low certainty-of-evidence due to study methodological limitations and imprecision. Hand-body hygiene interventions may improve knowledge, attitudes and practices (SMD 2.30, 95%CI 1.17 to 3.44, 6 studies, 7301 participants), increase handwashing practices (RR 1.75, 95%CI 1.41 to 2.17, 5 studies, 5479 participants), and reduce infection-related absenteeism (RR 0.74, 95%CI 0.66 to 0.83, 5 studies, 1017852 observations). Genital hygiene interventions may improve attitude (SMD 6.53, 95%CI 2.40 to 10.66, 2 studies, 2644 participants) and practices (RR 2.44, 95%CI 1.28 to 4.68, 1 study, 1201 participants). However, intervention effects on oral hygiene appeared mixed, with worsening of the oral hygiene score (SMD 3.12, 95%CI 1.87 to 4.37, 2 studies, 652 participants) but improved dental hygiene (SMD -0.33, 95%CI -0.53 to -0.13, 3 studies, 4824 participants) and dental caries scores (SMD -0.34, 95%CI -0.52 to -0.16, 4 studies, 2352 participants). Limited evidence suggests that interventions targeting hand-body and genital hygiene practices may improve knowledge, practices, and infection-related absenteeism. However, the effects on oral hygiene intervention appeared mixed. Future research should strengthen randomisation and intervention documentation, and evaluate hygiene-related behaviour, academic performances and health outcomes.
Role of cell surface proteins and toll-like receptors in the pathogenesis of Streptococcus pneumoniae Nurul Fathiyah Zaipul Anuar, M. M. Mohd Desa, Jamal Hussaini, E. H. Wong, V. Mariappan, et al. Iranian Journal of Basic Medical Sciences, 2024 Objective(s): Pneumococcal cell wall (PCW) is an inflammatory component in Streptococcus pneumoniae. The cell surface proteins and the toll-like receptors (TLR) signaling response were investigated in the human lung epithelial (A549) cells inoculated with PCW of different serotypes. Materials and Methods: The presence of genes encoding these proteins was determined using polymerase chain reaction (PCR). The structure of the cell walls was analyzed by proton nuclear magnetic resonance (1H NMR). The A549 cell line was challenged with PCW extracts of different serotypes. RNA from the infected host cells was extracted and tested against a total of 84 genes associated with TLR signaling pathways (TLR 1-6 and 10) using RT2 Profiler PCR Array. Results: Cell surface proteins; ply, lytA, nanA, nanB, and cbpD genes were present in all serotypes. The distribution and structure of surface protein genes suggest behavioral changes in the molecules, contributing to the resilience of the strains to antibiotic treatment. Conclusion: TLR2 showed the highest expression, while serotypes 1, 3, and 5 induced higher TNFα and IL-1α, suggesting to be more immunogenic than the other strains tested
The Association between Uric Acid Level and Ischemic Stroke Yang Xu, Eng Hwa Wong, Bin Nordin Rusli, Kareem Meera Mohaideen Abdul, Samraj Prakash Earnest Benjamin, et al. Obm Neurobiology, 2024 Stroke is the second and third leading cause of death and disability, respectively, all over the world. It seriously affects patients' lives and brings huge burdens to their families. Ischemic stroke accounts for most of the stroke cases. In the absence of any effective treatment, prevention measures through controlling the risk factors for ischemic stroke become crucial. While uric acid has been reported as an essential risk factor for ischemic stroke, researchers hold inconsistent views regarding the specific association between uric acid and ischemic stroke. By summarizing the association between uric acid levels and ischemic stroke, this article can guide researchers to quickly and comprehensively understand the relationship between uric acid and ischemic stroke and develop further studies for its exploration.
Biochemistry risk factors for ischemic stroke Yang Xu, Wong Eng Hwa, Rusli Bin Nordin, Abdul Kareem Meera Mohaideen, Benjamin Samraj Prakash Earnest, et al. Romanian Journal of Neurology Revista Romana De Neurologie, 2023
Diagnosis of lung related diseases by assessing vibration patterns of structures at the thoracic cavity Journal of Engineering Science and Technology, 2017
Adherence of Streptococcus pneumoniae and expression analysis of neuraminidase gene (NanA and NanB) after interaction of A549 human lung epithelial cells with pneumococcal strains of various serotypes Malaysian Journal of Microbiology, 2017
Evaluation of locomotor function and microscopic structure of the spinal cord in a mouse model of experimental autoimmune encephalomyelitis following treatment with syngeneic mesenchymal stem cells International Journal of Clinical and Experimental Pathology, 2015
Iron regulated outer membrane proteins (IROMPs) as potential targets against carbapenem-resistant Acinetobacter spp. isolated from a Medical Centre in Malaysia Indian Journal of Medical Research, 2010
Detection and characterization of class 1 integrons among carbapenem-resistant isolates of Acinetobacter spp. in Malaysia Journal of Microbiology Immunology and Infection, 2009
RECENT SCHOLAR PUBLICATIONS
Identification of Immunogenic and Virulence-Associated Proteins in Streptococcus pneumoniae Extracellular Membrane Vesicles NA Johari, FM Nor, NFZ Anuar, MNM Desa, EH Wong, V Mariappan, ... 2026
From ferments to fixers: Postbiotics in wound healing HS Lim, CJ Serpell, S Ogawa, YY Hu, EH Wong Medicine in Drug Discovery, 100249 , 2026 2026
5, 7, 3′, 4′, 5′-pentamethoxyflavone (PMF) exhibits anti-obesity and neuroprotective effects in an obese zebrafish model MS Vohra, B Ahmad, ER Taylor, K Benchoula, IL Fong, IS Parhar, ... Molecular and cellular endocrinology 604, 112554 , 2025 2025 Citations: 1
From Fins to Furs: Unlocking the Therapeutic Potential of Animal-derived Bioactives for Wound Care HS Lim, CJ Serpell, S Ogawa, YY Hu, EH Wong Medicine in Drug Discovery 26, 100206 , 2025 2025 Citations: 1
Understanding the future of dengue in Malaysia: Assessing knowledge, attitude, and homeowner practices in mitigating climate-driven risks JA Andoy-Galvan, SS Patil, YH Wong, P Madhavan, LH Wee, PP Chong, ... F1000Research 13, 1355 , 2024 2024
The effects of school-based hygiene intervention programme: Systematic review and meta-analysis SR Ismail, R Radzi, PSN Megat Kamaruddin, EF Lokman, HY Lim, ... Plos one 19 (10), e0308390 , 2024 2024 Citations: 31
Role of cell surface proteins and toll-like receptors in the pathogenesis of Streptococcus pneumoniae NF Zaipul Anuar, MN Mohd Desa, J Hussaini, EH Wong, V Mariappan, ... Iranian Journal of Basic Medical Sciences 27 (2), 214-222 , 2024 2024 Citations: 2
The Association between Uric Acid Level and Ischemic Stroke Y Xu, EH Wong, R Bin Nordin, A Kareem Meera Mohaideen, ... OBM Neurobiology 8 (1), 1-27 , 2024 2024
Role of cell surface proteins and toll-like receptors in the pathogenesis of Streptococcus pneumoniae NFZ Anuar, MNM Desa, J Hussaini, EH Wong, V Mariappan, ... Iranian Journal of Basic Medical Sciences 27 (2), 214 , 2024 2024 Citations: 4
Unveiling synergism of polymyxin B with chloramphenicol derivatives against multidrug-resistant (MDR) Klebsiella pneumoniae N Idris, KH Leong, EH Wong, N Abdul Rahim The Journal of Antibiotics 76 (12), 711-719 , 2023 2023 Citations: 3
Extraction of Extracellular Membrane Vesicles (EMV) from Streptococcus pneumoniae using Ultracentrifugation, Ultrafiltration and Iodixanol Gradient Fractionation. NFZ Anuar, MNM Desa, J Hussaini, EH Wong, V Mariappan, ... Current Trends in Biotechnology & Pharmacy 17 , 2023 2023 Citations: 1
Development and physicochemical characterization of a biodegradable microspheres formulation loaded with samarium‐153 and doxorubicin for chemo‐radioembolization of liver tumours AH Alregib, HY Tan, YH Wong, A Kasbollah, EH Wong, BJJ Abdullah, ... Journal of Labelled Compounds and Radiopharmaceuticals 66 (10), 308-320 , 2023 2023 Citations: 12
Hydroxylated polymethoxyflavones reduce the activity of pancreatic lipase, inhibit adipogenesis and enhance lipolysis in 3T3-L1 mouse embryonic fibroblast cells B Ahmad, EP Friar, MS Vohra, N Khan, CJ Serpell, MD Garrett, JSE Loo, ... Chemico-Biological Interactions 379, 110503 , 2023 2023 Citations: 9
Characterization of Physicochemical, Biological, and Chemical Changes Associated with Coconut Milk Fermentation and Correlation Revealed by 1 H NMR-Based … WSM Qadi, A Mediani, K Benchoula, EH Wong, NM Misnan, NA Sani Foods 12 (10), 1971 , 2023 2023 Citations: 42
Streptococcus pneumoniae using Ultracentrifugation, Ultrafiltration and Iodixanol Gradient Fractionation. Z Anuar, MNM Desa, J Hussaini, EH Wong, V Mariappan, KM Vellasamy Current Trends in Biotechnology & Pharmacy 17 , 2023 2023
The functions of Ca 2+ /calmodulin-dependent protein kinase II (CaMKII) in diabetes progression K Benchoula, A Mediani, WE Hwa Journal of Cell Communication and Signaling 17 (1), 25-34 , 2023 2023 Citations: 30
Anti-pancreatic lipase and anti-adipogenic effects of 5, 7, 3′, 4′, 5′-pentamethoxy and 6, 2′, 4′-trimethoxy flavone-An in vitro study B Ahmad, EP Friar, E Taylor, MS Vohra, CJ Serpell, MD Garrett, JSE Loo, ... European Journal of Pharmacology 938, 175445 , 2023 2023 Citations: 11
Nanoprobes for advanced nanotheranostic applications MA Saleemi, EH Wong Advanced Nanoformulations, 557-586 , 2023 2023 Citations: 2
A systematic review of molecular hydrogen therapy in cancer management MNZM Noor, AS Alauddin, YH Wong, CY Looi, EH Wong, P Madhavan, ... Asian Pacific journal of cancer prevention: APJCP 24 (1), 37 , 2023 2023 Citations: 43
In silico genome-scale metabolic modeling and in vitro static time-kill studies of exogenous metabolites alone and with polymyxin B against Klebsiella pneumoniae WY Chung, N Abdul Rahim, MH Mahamad Maifiah, ... Frontiers in Pharmacology 13, 880352 , 2022 2022 Citations: 4
MOST CITED SCHOLAR PUBLICATIONS
An overview of Acinetobacter baumannii pathogenesis: Motility, adherence and biofilm formation HJ Mea, PVC Yong, EH Wong Microbiological research 247, 126722 , 2021 2021 Citations: 266
Molecular mechanisms of adipogenesis: the anti-adipogenic role of AMP-activated protein kinase B Ahmad, CJ Serpell, IL Fong, EH Wong Frontiers in molecular biosciences 7, 76 , 2020 2020 Citations: 255
AgRP/NPY and POMC neurons in the arcuate nucleus and their potential role in treatment of obesity MS Vohra, K Benchoula, CJ Serpell, WE Hwa European journal of pharmacology 915, 174611 , 2022 2022 Citations: 205
Bacopa monnieri , a Neuroprotective Lead in Alzheimer Disease: A Review on Its Properties, Mechanisms of Action, and Preclinical and Clinical Studies AS Abdul Manap, S Vijayabalan, P Madhavan, YY Chia, A Arya, EH Wong, ... Drug target insights 13, 1177392819866412 , 2019 2019 Citations: 192
Review: Antimicrobial properties of allicin used alone or in combination with other medications. PPC Sulin Choo, Voon Kin Chin, Eng Hwa Wong, Priya Madhavan, Sun Tee Tay ... Folia Microbiologica 65, 451–465 , 2020 2020 Citations: 141
Carbon nanotubes toxicity: molecular mechanisms, signaling cascades and remedies in biomedical applications. EHW Saleemi Mansab Ali, Hosseini Fouladi Mohammad, Yong Phelim Chinna ... Chemical Research in Toxicology , 2020 2020 Citations: 135
Synergistic Effects of Curcumin and Piperine as Potent Acetylcholine and Amyloidogenic Inhibitors with Significant Neuroprotective Activity in SH-SY5Y cells via Computational … SKPM Aimi Syamima Abdul Manap, Amelia Cheng Wei Tan, Weng Hhin Leong ... Frontiers in Aging Neuroscience 11, 206 , 2019 2019 Citations: 116
An overview of antimicrobial properties of carbon nanotubes-based nanocomposites MA Saleemi, YL Kong, PVC Yong, EH Wong Advanced Pharmaceutical Bulletin 12 (3), 449 , 2021 2021 Citations: 100
Brown/Beige adipose tissues and the emerging role of their secretory factors in improving metabolic health: The batokines B Ahmad, MS Vohra, MA Saleemi, CJ Serpell, IL Fong, EH Wong Biochimie 184, 26-39 , 2021 2021 Citations: 76
FoxO1 signaling as a therapeutic target for type 2 diabetes and obesity K Benchoula, A Arya, IS Parhar, WE Hwa European journal of pharmacology 891, 173758 , 2021 2021 Citations: 72
Elucidation of Antimicrobial Activity of Non-Covalently Dispersed Carbon Nanotubes. PVCYEHW Mansab Ali Saleemi, Mohammad Hosseini Fouladi Materials 13 (7), 1676 , 2020 2020 Citations: 58
An overview of recent development in therapeutic drug carrier system using carbon nanotubes. EHW M.A Saleemi, Y.L. Kong, P.V.C. Yong Journal of Drug Delivery Science and Technology 59, 101855 , 2020 2020 Citations: 57
CREB nuclear transcription activity as a targeting factor in the treatment of diabetes and diabetes complications K Benchoula, IS Parhar, P Madhavan, WE Hwa Biochemical pharmacology 188, 114531 , 2021 2021 Citations: 47
Mechanisms of action for the anti-obesogenic activities of phytochemicals. EH Ahmad, B., Friar, E. P., Vohra, M. S., Garrett, M. D., Serpell, C. J ... Phytochemistry 180 (112513) , 2020 2020 Citations: 44
A systematic review of molecular hydrogen therapy in cancer management MNZM Noor, AS Alauddin, YH Wong, CY Looi, EH Wong, P Madhavan, ... Asian Pacific journal of cancer prevention: APJCP 24 (1), 37 , 2023 2023 Citations: 43
Characterization of Physicochemical, Biological, and Chemical Changes Associated with Coconut Milk Fermentation and Correlation Revealed by 1 H NMR-Based … WSM Qadi, A Mediani, K Benchoula, EH Wong, NM Misnan, NA Sani Foods 12 (10), 1971 , 2023 2023 Citations: 42
The crosstalk of hedgehog, PI3K and Wnt pathways in diabetes K Benchoula, IS Parhar, EH Wong Archives of biochemistry and biophysics 698, 108743 , 2021 2021 Citations: 41
The effects of school-based hygiene intervention programme: Systematic review and meta-analysis SR Ismail, R Radzi, PSN Megat Kamaruddin, EF Lokman, HY Lim, ... Plos one 19 (10), e0308390 , 2024 2024 Citations: 31
The functions of Ca 2+ /calmodulin-dependent protein kinase II (CaMKII) in diabetes progression K Benchoula, A Mediani, WE Hwa Journal of Cell Communication and Signaling 17 (1), 25-34 , 2023 2023 Citations: 30
Investigation of antimicrobial activity and cytotoxicity of synthesized surfactant-modified carbon nanotubes/polyurethane electrospun nanofibers. PVCYEHW Mansab Ali Saleemi Nano-Structure and Nano-Objects 24, 100612 , 2020 2020 Citations: 30