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College of Science / Department of Biology
University of Baghdad
embryology and histology
Iraqi Journal of Science, ISSN: 00672904, eISSN: 23121637, Pages: 1843-1849, Published: 2 July 2021
Iraqi Journal of Science, ISSN: 00672904, eISSN: 23121637, Pages: 1836-1842, Published: 2 July 2021
Hadeer H. Shamsulddin, Lina A. Salih, and Samia A. Eleiwe
Iraqi Journal of Science, ISSN: 00672904, eISSN: 23121637, Pages: 2494-2503, Published: 2020 University of Baghdad College of Science
Osteopontin hormone (OPN) is an extracellular matrix protein that is expressed in bone cells such as osteoblasts and osteoclasts and associated with bone turnover and bone mineral density (BMD) in postmenopausal women with osteoporosis.
The aim of the study is to investigate serum levels of circulating OPN and its relationship with biochemical parameters and BMD in postmenopausal women with osteoporosis in Iraq. Serum samples from fifty postmenopausal women were selected from patients attending two educational hospitals in Baghdad, which are AL Wasity Educational Hospital and Baghdad Educational Hospital, during the period from November 2018 to March 2019. Twenty five postmenopausal healthy women were included as a control group. The studied subjects’ ages were in the range of 45-65 years. Dual energy X-ray absorptiometry (DEXA) was the device used to measure bone mineral density and diagnose osteoporosis in both groups. Blood samples were collected from each participant for measuring the serum levels of biochemical parameters (P, Alp, Ca, and OPN)
The results of the demographic parameters showed a significant (P≤0.05) increase in mean values of age, menopause duration, and duration of productive life in the patients as compared to the control group. Also, strong positive correlations between patients and the control were recorded in age and duration of productive age, with a weak inverse correlation in menopause duration. While a significant (P≤0.05) decrease in the mean value of body mass index (BMI), BMD, and T-score as compared to the control. The correlation in BMI was weak significant positive while in the other two parameters it was weak significant inverse.
The results of the present study showed non-significant differences (P ≥0.05) between the patients and control group for serum biochemical parameters.
It was also noticed that there was a significant (P≤0.05) increase in the mean value of osteopontin hormone level in the patients as compared to the control, with a weak significant inverse (p≤0.05) correlation.
Ali & et al.
Iraqi Journal of Agricultural Sciences, ISSN: 00750530, eISSN: 24100862, Pages: 1605-1612, Published: 2020 University of Baghdad - College of Agriculture
This study was aimed to displayed effect of this nanoparticles on pregnant mother and embryos. All females administration of AgNPs suspension orally during the gestational period (for 21day) in two doses low 2mg and high dose 20 mg /Kg body weight and the control group received D.W only. The pregnant females (60 females) include the control group and the treated group was subdivided in to two groups, pre and post implantation and all the mothers weighted along the study. The embryos and their brains after retrieved weighted and the crow-rump length (CRL) measurement also. The results showed that the active form of Ag can be transport the placental barrier and blood brain barrier (BBB). This nanoparticles showed adverse effect and produced decreased in mothers weights in low dose 2mg/Kg/ B.Wt and higher dose 20mg/Kg/ B.Wt. Weights of embryos were lower clearly after exposure to AgNPs compare to control group. On the other hand, the weights of embryo's brain were decreased compare of control group in both doses. The CRL of embryos lowered after exposure to AgNPs in treatment groups when compare to control group.
Journal of Global Pharma Technology, eISSN: 09758542, Pages: 730-741, Published: 2019
S. Bayram, Lina A. Salih and Samia. A. Eleiwe
Iraqi Journal of Science, ISSN: 00672904, eISSN: 23121637, Pages: 1786-1791, Published: 31 October 2018 University of Baghdad College of Science
Pregnancy-induced hypertension (PIH) is a major pregnancy complication that causes pregnant women mortality. Here, we had scrutinized the correlation between serum levels of ?-hCG and biochemical parameters in PIH. Serum samples were collected from eighty Iraqi women (forty women with pregnancy-induced hypertension as patients group, twenty normotensive pregnant women as a positive control, and twenty normotensive non-pregnant women as a negative control) all groups were diagnosed clinically. All ?-hCG hormone level was measured for all studied groups, also serum uric acid, albumin, and total protein levels were measured as biochemical parameters. Data analysis showed that serum level of ?-hCG hormone was significant increase (p?0.05) in PIH in compared to control groups. Also Uric acid level was increased significantly in PIH group in compared with control groups. While Albumin show there was no significant difference in PIH group. Total serum protein level was measured by Bradford total Protein assay all results was in normal value and showed a significant difference in PIH group in comparison to control groups. Our study shows that there is correlation between ?-hCG with uric acid and albumin levels in PIH. Serial estimation of serum ?-hCG, uric acid, and albumin can be important to use as a marker of disease and also can be used in better early management of established cases that lead to preeclampsia and eclampsia.
Esraa H. Ali and Lina A. Salih
Iraqi Journal of Science, ISSN: 00672904, eISSN: 23121637, Pages: 371-377, Published: 2018 University of Baghdad College of Science
The central nervous system is the most important system and is very sensitive to any accidental infection during ontogenesis; it includes brain and spinal cord. The cerebellum is the second largest part of the brain after cerebrum and it�s very sensitive to the abnormal changes during the embryological development. This study was designed to investigate the effect of the maternal exposure of selected concentrations of suspension of nanoparticles on the ontogenesis of the rat cerebellum after embryos implanted in uterus. A total of 60 female pregnant rats were divided in to three groups, each contains 20 females. Group1 (G1) was treated orally with 2mg/kg /body weight (b. wt) of suspension of silver nanoparticles (Ag NPs). While group 2 (G2) was treated with 20mg/kg/b. wt of AgNPs after implantation from 7 th day of pregnancy until delivery at day 21 st, for 15 day. And group3 (G3) was considered as control whose received Distal water (D.W) only. We had selected the following embryonic day for treatment (ED12, 15, 18 and 21). The histological results showed a defect in the ontogenesis of the cerebellum cortex layers of embryos, through lack of density of external granular layer, as well as degeneration and dispersion of the glial cells in the internal granular layer of cerebellar cortex, in addition to less distribution of cells in the molecular layer due to the ability of AgNPs to pas the placenta and blood brain barrier (BBB) to the embryo�s brain after female exposure to the AgNPs during pregnancy. AgNPs at low concentration 2mg/kg/day and higher concentration 20mg/kg/day can produce many histological toxicity to the embryo�s hindbrain and cerebellum when administrated to the dams during pregnancy period.
Saja Muhand Bayram, Lina A Salih, and Samia A Eleiwe
Asian Journal of Pharmaceutical and Clinical Research, ISSN: 09742441, eISSN: 24553891, Pages: 430-432, Published: 2018 Innovare Academic Sciences Pvt Ltd
Objective: Pregnancy-induced hypertension (PIH) is a major pregnancy complication that leads to maternal mortality. Here, we have scrutinized the correlation between serum levels of hydrogen peroxide (H2O2) and superoxide dismutase (SOD) in PIH.Methods: Serum samples were collected from 80 Iraqi women (40 women with PIH as patients group, 20 normotensive pregnant women as a positive control, and 20 normotensive non-pregnant women as a negative control) all groups were diagnosed clinically.Results: Serum of H2O2 and SOD levels was measured for all studied groups. Results showed that there were no significant variances in age and gestational age distribution between all studied groups. Furthermore, result showed that the serum level of SOD was a highly significant decrease in PIH in compared to control groups while H2O2 was a highly significant increase in PIH in compared with control groups. The obtained results also indicated that there was a negative correlation between SOD and H2O2 PIH women while no correlation in other control groups.Conclusion: Our study showed that there was a correlation between H2O2 levels and SOD in PIH. These imbalance lead to generate oxidative stress that could be responsible for starting and progression of pathological processes related to PIH and may be a critical determinant of diseases. Testing for SOD and H2O2 level can be a monitoring instrument for oxidative stress in early pregnancy, and they could help in the detection and consequently prevent future hypertension in pregnancy.