Neoadjuvant ultrahypofractionated radiotherapy with simultaneous integrated boost for glioblastoma: study protocol for a phase I multicenter clinical trial Nadia Di Muzio, Miriam Torrisi, Raffaella Barzaghi, Arianna Pocaterra, Martina Mori, Filippo Folchini, Laura Giannini, Micol Valle, Michele Bailo, Chiara Lucrezia Deantoni, Silvia Snider, Filippo Gagliardi, Eliana Ruggiero, Sara Broggi, Luca Ruffino, Rossella Di Franco, Simona Mercogliano, Claudio Fiorino, Antonella Del Vecchio, Matteo Muto, Paolo Muto, Pietro Mortini, Anna Mondino, Andrei Fodor BMC Cancer, 2026 BACKGROUND: The Stupp protocol standardized adjuvant radiotherapy (RT) with temozolomide as the best treatment after glioblastoma (GBM) resection. Later phase III trials found that moderate hypofractionation and ultrahypofractionation were not inferior in elderly or frail patients. As most recurrences occurred near the tumor bed, RT margins could be reduced, favoring ultrahypofractionated RT (UHRT). Neoadjuvant UHRT might provide additional benefits by allowing better margin selection and lowering radionecrosis risk through the surgical removal of the irradiated tissue. METHODS: This is a phase I, single-arm, multicenter clinical trial having as primary endpoint the identification of maximum tolerated dose in operable GBM patients. A total dose of 30 Gy delivered in 5 fractions will be prescribed to planning target volume, with a simultaneous integrated boost dose escalation to gross tumor volume from 35 to 50 Gy, with 5 patients at each dose level. Dose to the next patient group will be escalated if toxicity target is met. The assumption is that not more than 30% of patients would present cumulative ≥G3 toxicity (CTCAE v5.0 scale) one month after the end of UHRT. A 30-patient sample size is predicted to result in a 2-sided 95% confidence interval with a width of 0.328 (0.136–0.464) when the sample proportion is 0.300. Four weeks after the end of UHRT, following a brain MRI, the lesion will be surgically removed. A peripheral blood sample will be taken before and after UHRT, up to 6 months, for immunophenotyping. DISCUSSION: The study aims at evaluating MRI-guided dose escalation neoadjuvant UHRT-related toxicity along with potential improvements in overall- and disease-free survival. Other goals are to identify prognostic factors and monitor radiation-treatment related immune effects. An important expected benefit of the neoadjuvant UHRT is that it will shorten treatment time, improving patients’ quality of life, and facilitate access to specialized treatment centers. Neoadjuvant RT represents a paradigm shift in GBM, and implications for the scientific community should be significant. The study may help identify distribution patterns of aggressive radioresistant areas with a higher probability of recurrence, counteract intrinsic radioresistance, and identify immune correlates of therapeutic efficacy and/or biomarkers of treatment response/toxicity. TRIAL REGISTRATION: The study was prospectively registered at clinicaltrials.gov (NCT06551909, 13/08/2024). Protocol version: Version 1.0, 17/06/2024.
Light Quality Modulates the Antioxidant Properties of “Microtom” Fruits: A Pilot Study Testing the Radioprotective Effect on Human Cells Filippo Villano, Valerio Cosimo Elia, Ermenegilda Vitale, Valentina d’Alesio, Gianluca Ametrano, Francesca Fede, Emilia Formicola, Alexandros G. Georgakilas, Paolo Muto, Marcello Serra, Carmen Arena, Lorenzo Manti International Journal of Molecular Sciences, 2026 The fruits of Solanum lycopersicum L. cultivar “Microtom” are a powerful source of antioxidants. We investigated whether two light-quality regimes, i.e., fluorescent white (FL) and red-blue (RB), influenced the antioxidant composition in such fruits, and assessed the potential radioprotective properties of their extracts on normal human cells exposed to clinical photons as used in cancer radiotherapy (RT). Increasing normal-tissue tolerance to radiation is critical for reducing the risk of RT-associated sequelae. Biochemical characterization showed that RB enhanced the content of antioxidant phytochemicals (i.e., polyphenols, flavonoids, total carotenoids, lycopene), while FL promoted ascorbic acid synthesis. Initially tested at 200 µg/mL, RB-derived extracts decreased radiation-induced DNA damage as measured by the cytokinesis-block micronucleus (CBMN) assay in epidermal HaCaT cells. Both RB and FL regimes were subsequently studied in MCF-10A breast cancer (BC) cells, a model of normal-tissue radioresponse in BC RT, using extracts at 100 and 200 µg/mL and also evaluating oxidative stress by a ROS detection assay. Both FL and RB afforded radioprotection. However, RB suppressed radiation-induced MN formation and oxidative stress to a greater extent compared to FL. Therefore, modulation of light-quality regimes represents an innovative approach for developing radionutraceuticals with potential benefits for RT patients.
Optimizing Left-Sided Breast Cancer Radiotherapy: Strategy-Dependent Trade-Offs Among VMAT and Hybrid Techniques Rocco Mottareale, Francesca Buonanno, Valentina d'Alesio, Sara Falivene, Marcello Serra, Cecilia Arrichiello, Gianluca Ametrano, Piera Ferraioli, Gaetano Gagliardo, Rossella Di Franco, Simona Mercogliano, Paolo Muto, Vincenzo Ravo Cancer Management and Research, 2026 Purpose: To compare dosimetric trade-offs among two full-VMAT and two hybrid 3D-CRT/VMAT strategies for left-sided whole-breast irradiation (WBI), and to evaluate the influence of planning strategy, introducing a novel tangential hybrid approach (H-tVMAT). Patients and Methods: Twenty patients with left-sided breast cancer treated with WBI (40.05 Gy in 15 fractions) were retrospectively analyzed. For each patient, four plans were generated within a single treatment planning system under free-breathing conditions: large-angle VMAT, tangential VMAT (tVMAT), Hybrid VMAT (H-VMAT), and the novel tangential Hybrid tVMAT (H-tVMAT). Primary dosimetric endpoints included heart and pulmonary structures and the contralateral breast, with dedicated evaluation of low-dose exposure. Target conformity, homogeneity index (HI), and monitor units (MUs) were also assessed. Results: All strategies achieved clinically acceptable target coverage and homogeneity. Hybrid configurations consistently reduced cardiac, pulmonary, and contralateral low-dose exposure compared with full-VMAT solutions. Among the evaluated strategies, H-tVMAT provided the most favorable balance between heart/LAD sparing, low-dose containment, and target coverage. Appropriately configured tangential VMAT achieved dosimetric results close to hybrid solutions, underscoring the importance of arc geometry. No statistically significant differences in delivery complexity were observed across strategies. Conclusion: Dosimetric performance in left-sided WBI is strongly influenced by planning implementation rather than nominal technique category alone. Hybrid tangential VMAT achieved the most balanced dosimetric profile, while optimized tangential VMAT provided comparable results. These findings support a strategy-specific approach to technique selection, emphasizing the central role of implementation choices in breast radiotherapy planning.
Radiation quality matters: morphological and biochemical responses of Brassica rapa microgreens to X-rays, C-ions, and Fe-ions Sara De Francesco, Chiara Amitrano, Ermenegilda Vitale, Giulia Costanzo, Walter Tinganelli, Mariagabriella Pugliese, Cecilia Arrichiello, Paolo Muto, Marco Durante, Stefania De Pascale, Carmen Arena, Veronica De Micco Planta, 2025 Main Conclusion Radiation type and dose distinctly modulate microgreens development, revealing trait-specific thresholds where X-rays induce hormesis, carbon ions delay differentiation, and iron ions enhance biochemical balance with moderate anatomical disruption. Abstract As space exploration progresses and controlled-environment agriculture becomes increasingly relevant under extreme conditions, understanding how ionizing radiation affects plant development is crucial. Ionizing radiation poses a major constraint in space cultivation systems, also playing a role in terrestrial stress scenarios. Despite growing interest in radiation biology, few studies have systematically compared plant responses to different radiation types with distinct linear energy transfer (LET). In this study, seeds of Brassica rapa L. were exposed to increasing doses of X-rays (low-LET), carbon ions, and iron ions (high-LET). Seed germination, morpho-anatomical, and biochemical traits of plants were assessed up to the microgreens stage. Plant responses were both dose- and radiation-specific. Specifically, X-rays triggered a hormetic response at low doses (1 Gy), with a decline in several analyzed traits at higher doses. Carbon ions increased leaf expansion but reduced the content of pigments, proteins, and the structural investment, suggesting a delayed tissue differentiation and low-cost acclimation mechanism under stress. Iron ions promoted a coordinated upregulation of biochemical defenses and moderate anatomical changes. Overall, radiation quality induced distinct acclimation strategies in B. rapa, influencing the balance between growth, structural integrity, and defense mechanisms, highlighting its notable radioresistance. Moreover, identifying trait-specific thresholds and response patterns suggests that different radiation types could be selectively applied to modulate specific functions (e.g., biomass or antioxidants promotion, anatomical adjustments) based on desired outcomes. These findings provide valuable insights into how different ionizing radiation types impact plant responses, addressing a critical gap in space-oriented research and guiding strategies to optimize plant growth in extraterrestrial environments.
Evaluating dosimetric outcomes: a comparison of CyberKnife, VMAT FFF, and Helical Tomotherapy Radixact for treating localized prostate cancer Gaetano Gagliardo, Marcello Serra, Gianluca Ametrano, Marco Galiero, Cecilia Arrichiello, Valentina Borzillo, Francesca Buonanno, Valentina d’Alesio, Rossella Di Franco, Paolo Muto Radiologia Medica, 2025 Prostate cancer (PCa) remains one of the most frequently diagnosed malignancies in men globally, ranking second in prevalence, with increasing incidence anticipated due to aging populations. Radiotherapy has emerged as a cornerstone treatment for localized PCa with stereotactic body radiation therapy (SBRT), and it offers a promising approach by delivering highly conformal high-dose radiation in fewer fractions. This study compares the dosimetric outcomes of three SBRT techniques—CyberKnife (CK), Volumetric Modulated Arc Therapy with flattening filter-free mode (VMAT FFF), and Helical Tomotherapy Radixact (HT)—for localized PCa. The investigation evaluates dose distribution characteristics, sparing of organs at risk (OARs), and treatment delivery efficiency. Two patient groups with low-to-intermediate-risk localized PCa treated at the Istituto Nazionale Tumori—IRCCS Fondazione G. Pascale were included. Treatment plans for CK, VMAT FFF, and HT were retrospectively generated and analyzed using dosimetric metrics such as Conformity Index (CI), Homogeneity Index (HI), Gradient Index, and dose–volume constraints for OARs. Results revealed comparable target coverage across all techniques, with CK demonstrating superior dose conformity and VMAT FFF achieving shorter treatment times. HT and VMAT FFF are effective alternatives, particularly for centers without access to CK systems, though CK offered advantages in challenging anatomical scenarios. Findings emphasize the feasibility of VMAT FFF and HT as viable options for expanding SBRT accessibility, enabling high-quality treatment delivery in diverse clinical settings.
Holographic Imaging Flow Cytometry for radiation response assessment in lymphocytes Daniele Pirone, Rocco Mottareale, Giusy Giugliano, Chiara de Vita, Giuseppe La Verde, Jaromir Behal, Cecilia Arrichiello, Paolo Muto, Ivana Kurelac, Laura Bagnale, Mario Medugno, Pasquale Memmolo, Vittorio Bianco, Lisa Miccio, Pier Luca Maffettone, Marco Durante, Pietro Ferraro, Mariagabriella Pugliese Proceedings of SPIE the International Society for Optical Engineering, 2025
Targeting Tumor Microenvironment Mechanics: The Role of ECM Stiffness in Lung Adenocarcinoma Response to Radiotherapy Convegno Nazionale Di Bioingegneria, 2025
PEACE V-Salvage Treatment of OligoRecurrent nodal prostate cancer Metastases (STORM): Acute Toxicity of a Randomized Phase 2 Trial Piet Ost, Shankar Siva, Sigmund Brabrand, Piet Dirix, Nick Liefhooghe, François-Xavier Otte, Alfonso Gomez-Iturriaga, Wouter Everaerts, Mohamed Shelan, Antonio Conde-Moreno, Fernando López Campos, Alexandros Papachristofilou, Matthias Guckenberger, Marta Scorsetti, Almudena Zapatero, Ana-Elena Villafranca Iturre, Clara Eito, Felipe Couñago, Paolo Muto, Lien Van De Voorde, Nicolas Mach, Renée Bultijnck, Valérie Fonteyne, Daniel Moon, Kristian Thon, Carole Mercier, Vérane Achard, Karin Stellamans, Els Goetghebeur, Dries Reynders, Thomas Zilli European Urology Oncology, 2024
Improving the quality of patient care in lung cancer: key factors for successful multidisciplinary team working Alessandro Morabito, Edoardo Mercadante, Paolo Muto, Anna Manzo, Giuliano Palumbo, Vincenzo Sforza, Agnese Montanino, Claudia Sandomenico, Raffaele Costanzo, Giovanna Esposito, Giuseppe Totaro, Rossella De Cecio, Carmine Picone, Annamaria Porto, Nicola Normanno, Arturo Capasso, Monica Pinto, Maura Tracey, Giuseppe Caropreso, Giacomo Pascarella Exploration of Targeted Anti Tumor Therapy, 2024
Management of radiation-induced oral mucositis in head and neck cancer patients: a real-life survey among 25 Italian radiation oncology centers Luca Bergamaschi, Maria Giulia Vincini, Mattia Zaffaroni, Matteo Pepa, Ilaria Angelicone, Antonio Astone, Cristiana Bergamini, Sergio Buonopane, Mario Conte, Nicola De Rosa, Chiara Deantoni, Italo Dell’Oca, Davide Di Gennaro, Nadia Di Muzio, Mattia Falchetto Osti, Manuela Federico, Gianluca Ferini, Ciro Franzese, Marco Gatti, Antonietta Grillo, Vincenzo Iorio, Roberto Manzo, Luca Marmiroli, Giuseppe Martin, Federica Mazzuca, Maria Angela Molinaro, Matteo Muto, Roberto Pacelli, Alfonsina Pepe, Annarita Perillo, Donatella Russo, Francesca Salerno, Pietro Spadaro, Anna Viola, Giuseppe Carlo Iorio, Paolo Muto, Umberto Ricardi, Daniela Alterio Supportive Care in Cancer, 2024
IL-6 as new prognostic factor in patients with advanced cutaneous squamous cell carcinoma treated with cemiplimab Domenico Mallardo, Ester Simeone, Lucia Festino, Marilena Tuffanelli, Vito Vanella, Claudia Trojaniello, Maria Grazia Vitale, Margaret Ottaviano, Mariaelena Capone, Gabriele Madonna, Francesca Sparano, Eleonora Cioli, Luigi Scarpato, Marco Palla, Rossella Di Trolio, Paolo Meinardi, Corrado Caracò, Gerardo Ferrara, Paolo Muto, Ernesta Cavalcanti, Paolo Antonio Ascierto Journal of Translational Medicine, 2023
Oligo-metastatic neoPlasms from the gastro-intestinal tract: iDentIfiCaTIon of cliNical and molecular drivers: the PREDICTION study Alessandro Ottaiano, Antonella De Luca, Mariachiara Santorsola, Giosuè Scognamiglio, Annabella Di Mauro, Paolo Chiodini, Matilde Lambiase, Alessandra Sacco, Antonella Petrillo, Vincenza Granata, Roberta Fusco, Edoardo Mercadante, Nicola Martucci, Giuseppe De Luca, Antonello La Rocca, Egidio Celentano, Anna Crispo, Piergiacomo Di Gennaro, Fabiana Tatangelo, Gerardo Ferrara, Francesco Izzo, Andrea Belli, Renato Patrone, Paolo Delrio, Daniela Rega, Silvia De Franciscis, Paolo Muto, Vincenzo Ravo, Rossella Di Franco, Valentina Borzillo, Sara Santagata, Giuseppina Rea, Daniela Castaldo, Ugo Pace, Gianfranco De Feo, Stefania Scala, Guglielmo Nasti, Nicola Normanno BMC Cancer, 2023
Risk Management Activities in a Lung Cancer Multidisciplinary Team at a Comprehensive Cancer Center: Results of a Prospective Analysis Alessandro Morabito, Edoardo Mercadante, Paolo Muto, Giuliano Palumbo, Anna Manzo, Agnese Montanino, Claudia Sandomenico, Vincenzo Sforza, Raffaele Costanzo, Simona Damiano, Carmine La Manna, Nicola Martucci, Antonello La Rocca, Giuseppe De Luca, Giuseppe Totaro, Rossella De Cecio, Carmine Picone, Maria Carmela Piccirillo, Gianfranco De Feo, Maura Tracey, Stefania D'Auria, Nicola Normanno, Arturo Capasso, Giacomo Pascarella JCO Oncology Practice, 2023
Prognostic Score in Radiotherapy Practice for Palliative Treatments (PROPHET) Study for Bone Metastases: An Investigation Into the Clinical Effect on Treatment Prescription Francesco Cellini, Alessia Di Rito, Giambattista Siepe, Francesco Pastore, Elisabetta Lattanzi, Ilaria Meaglia, Angelo Tozzi, Stefania Manfrida, Silvia Longo, Simonetta Saldi, Raffaele Cassese, Fabio Arcidiacono, Michele Fiore, Valeria Masiello, Ciro Mazzarella, Antonio Diroma, Francesco Miccichè, Francesca Maurizi, Luca Dominici, Marta Scorsetti, Mario Santarelli, Vincenzo Fusco, Cynthia Aristei, Francesco Deodato, Maria A. Gambacorta, Ernesto Maranzano, Paolo Muto, Vincenzo Valentini, Alessio G. Morganti, Lorenza Marino, Costanza M. Donati, Rossella Di Franco Advances in Radiation Oncology, 2023
Oligo-Metastatic Cancers: Putative Biomarkers, Emerging Challenges and New Perspectives Alessandro Ottaiano, Mariachiara Santorsola, Luisa Circelli, Anna Maria Trotta, Francesco Izzo, Francesco Perri, Marco Cascella, Francesco Sabbatino, Vincenza Granata, Marco Correra, Luca Tarotto, Salvatore Stilo, Francesco Fiore, Nicola Martucci, Antonello La Rocca, Carmine Picone, Paolo Muto, Valentina Borzillo, Andrea Belli, Renato Patrone, Edoardo Mercadante, Fabiana Tatangelo, Gerardo Ferrara, Annabella Di Mauro, Giosué Scognamiglio, Massimiliano Berretta, Maurizio Capuozzo, Angela Lombardi, Jérôme Galon, Oreste Gualillo, Ugo Pace, Paolo Delrio, Giovanni Savarese, Stefania Scala, Guglielmo Nasti, Michele Caraglia Cancers, 2023
Diagnosis of space-induced effects on blood components by label-free optical technique and microfluidics Jaromir Behal, Zhe Wang, Lisa Miccio, Martina Mugnano, Pasquale Memmolo, Daniele Pirone, Vittorio Bianco, Giuseppe La Verde, Ivana Kurelac, Massimiliano Villone, MariaGabriella Pugliese, Cecilia Arrichiello, Francesca Ferranti, Paolo Muto, Silvia Mari, PierLuca Maffettone 2023 IEEE 10th International Workshop on Metrology for Aerospace Metroaerospace 2023 Proceedings, 2023
Concomitant medication of cetirizine in advanced melanoma could enhance anti-PD-1 efficacy by promoting M1 macrophages polarization Domenico Mallardo, Ester Simeone, Vito Vanella, Maria Grazia Vitale, Marco Palla, Luigi Scarpato, Miriam Paone, Teresa De Cristofaro, Valentina Borzillo, Alessio Cortellini, Francesca Sparano, Sandro Pignata, Francesco Fiore, Corrado Caracò, Piera Maiolino, Antonella Petrillo, Ernesta Cavalcanti, Secondo Lastoria, Paolo Muto, Alfredo Budillon, Sarah Warren, Paolo Antonio Ascierto Journal of Translational Medicine, 2022
Life style and interaction with microbiota in prostate cancer patients undergoing radiotherapy: study protocol for a randomized controlled trial Patrizia Gnagnarella, Giulia Marvaso, Barbara Alicja Jereczek-Fossa, Ottavio de Cobelli, Maria Claudia Simoncini, Luiz Felipe Nevola Teixeira, Annarita Sabbatini, Gabriella Pravettoni, Harriet Johansson, Luigi Nezi, Paolo Muto, Valentina Borzillo, Egidio Celentano, Anna Crispo, Monica Pinto, Ernesta Cavalcanti, Sara Gandini, Costanza Gavioli, Silvia Ciceri, Marialetizia Latella, Giulia Corrao, Dario Zerini, Debora Macis, Valentina Aristarco, Gabriele Cozzi, Ketti Mazzocco, Fodor Cristiana Iuliana, Serena Galiè, Carlotta Catozzi, Rossella Di Franco, Nunzio De Martino, Maria Grimaldi, Concetta Montagnese, Melania Prete, Flavia Nocerino, Emanuela Rotondo, Sergio Arpino, Serena Meola, Francesco Labonia, Federica Bellerba, and BMC Cancer, 2022
Oligorecurrent nodal prostate cancer: Radiotherapy quality assurance of the randomized PEACE V-STORM phase II trial Vérane Achard, Maud Jaccard, Frederik Vanhoutte, Shankar Siva, Reino Heikkilä, Piet Dirix, Nick Liefhooghe, François-Xavier Otte, Alfonso Gomez-Iturriaga, Charlien Berghen, Mohamed Shelan, Antonio Conde-Moreno, Fernando López Campos, Alexandros Papachristofilou, Matthias Guckenberger, Sabine Meersschout, Paul Martin Putora, Daniel Zwahlen, Felipe Couñago, Marta Scorsetti, Clara Eito, Marta Barrado, Almudena Zapatero, Paolo Muto, Lien Van De Voorde, Giorgio Lamanna, Nikolaos Koutsouvelis, Giovanna Dipasquale, Piet Ost, Thomas Zilli Radiotherapy and Oncology, 2022
The waiting time for prostate cancer treatment in Italy: Analysis from the PROS-IT CNR Study Mauro GACCI, Isabella GRECO, Walter ARTIBANI, Pierfrancesco BASSI, Filippo BERTONI, Sergio BRACARDA, Alberto BRIGANTI, Giorgio CARMIGNANI, Luca CARMIGNANI, Giario N. CONTI, Renzo CORVÒ, Cosimo DE NUNZIO, Ferdinando FUSCO, Pierpaolo GRAZIOTTI, Stefania MAGGI, Stefano M. MAGRINI, Vincenzo MIRONE, Rodolfo MONTIRONI, Giovanni MUTO, Marianna NOALE, Stefano PECORARO, Angelo PORRECA, Umberto RICARDI, Elvio RUSSI, Andrea SALONIA, Alchiede SIMONATO, Sergio SERNI, Andrea TUBARO, Vittorina ZAGONEL, Gaetano CREPALDI, and Minerva Urology and Nephrology, 2022
Health-related quality of life 24 months after prostate cancer diagnosis: An update from the Pros-IT CNR prospective observational study Carlotta PALUMBO, Alessio BRUNI, Alessandro ANTONELLI, Walter ARTIBANI, Pierfrancesco BASSI, Filippo BERTONI, Paolo BORGHETTI, Sergio BRACARDA, Alessandro CICCHETTI, Renzo CORVÒ, Mauro GACCI, Gianluca INGROSSO, Stefano M. MAGRINI, Marco MARUZZO, Vincenzo MIRONE, Rodolfo MONTIRONI, Giovanni MUTO, Marianna NOALE, Angelo PORRECA, Elvio RUSSI, Luca TRIGGIANI, Andrea TUBARO, Riccardo VALDAGNI, Stefania MAGGI, Giario N. CONTI, and Minerva Urology and Nephrology, 2022
Palliative radiotherapy indications during the COVID-19 pandemic and in future complex logistic settings: the NORMALITY model Francesco Cellini, Rossella Di Franco, Stefania Manfrida, Valentina Borzillo, Ernesto Maranzano, Stefano Pergolizzi, Alessio Giuseppe Morganti, Vincenzo Fusco, Francesco Deodato, Mario Santarelli, Fabio Arcidiacono, Romina Rossi, Sara Reina, Anna Merlotti, Barbara Alicja Jereczek-Fossa, Angelo Tozzi, Giambattista Siepe, Alberto Cacciola, Elvio Russi, Maria Antonietta Gambacorta, Marta Scorsetti, Umberto Ricardi, Renzo Corvò, Vittorio Donato, Paolo Muto, Vincenzo Valentini Radiologia Medica, 2021
Emergencies in oncology: An overview and practical suggestions Francesco Perri, Giuseppina Della Vittoria Scarpati, Carmine Pizza, Roberta Carella, Monica Pontone, Maria Luisa Marciano, F. Longo, M. Maglione, Sergio Buonopane, Roberto Manzo, A. Daponte, P. Muto, F. Ionna, M. Cascella Recenti Progressi in Medicina, 2021
Oligometastatic prostate cancer treatment Sabrina Rossetti, Marilena Di Napoli, Carmela Pisano, Sabrina C Cecere, Rosa Tambaro, Jole Ventriglia, Anna Passarelli, Gelsomina Iovane, Florinda Feroce, Secondo Lastoria, Francesca Di Gennaro, Paolo Muto, Valentina Borzillo, Rossella Di Franco, Sisto Perdonà, Giuseppe Quarto, Sandro Pignata Future Oncology, 2021
Immunotherapy in association with stereotactic radiotherapy for non-small cell lung cancer brain metastases: results from a multicentric retrospective study on behalf of AIRO Silvia Scoccianti, Emanuela Olmetto, Valentina Pinzi, Mattia Falchetto Osti, Rossella Di Franco, Saverio Caini, Paola Anselmo, Paolo Matteucci, Davide Franceschini, Cristina Mantovani, Giancarlo Beltramo, Francesco Pasqualetti, Alessio Bruni, Paolo Tini, Emilia Giudice, Patrizia Ciammella, Anna Merlotti, Sara Pedretti, Marianna Trignani, Marco Krengli, Niccolò Giaj-Levra, Isacco Desideri, Guido Pecchioli, Paolo Muto, Ernesto Maranzano, Laura Fariselli, Pierina Navarria, Umberto Ricardi, Vieri Scotti, Lorenzo Livi Neuro Oncology, 2021
RET inhibitors in non-small-cell lung cancer Priscilla Cascetta, Vincenzo Sforza, Anna Manzo, Guido Carillio, Giuliano Palumbo, Giovanna Esposito, Agnese Montanino, Raffaele Costanzo, Claudia Sandomenico, Rossella De Cecio, Maria Carmela Piccirillo, Carmine La Manna, Giuseppe Totaro, Paolo Muto, Carmine Picone, Roberto Bianco, Nicola Normanno, Alessandro Morabito Cancers, 2021
Prospective evaluation of radiotherapy-induced immunologic and genetic effects in colorectal cancer oligo-metastatic patients with lung-limited disease: The prelude-1 study Alessandro Ottaiano, Angela Petito, Mariachiara Santorsola, Valerio Gigantino, Maurizio Capuozzo, Daniela Fontanella, Rossella Di Franco, Valentina Borzillo, Sergio Buonopane, Vincenzo Ravo, Esmeralda Scipilliti, Giuseppe Totaro, Marcello Serra, Gianluca Ametrano, Roberta Penta, Fabiana Tatangelo, Giosuè Scognamiglio, Annabella Di Mauro, Maurizio Di Bonito, Maria Napolitano, Stefania Scala, Giuseppina Rea, Sara Santagata, Angela Lombardi, Anna Grimaldi, Carlo Caputo, Anna Crispo, Egidio Celentano, Gianfranco De Feo, Luisa Circelli, Giovanni Savarese, Raffaella Ruggiero, Francesco Perri, Vincenza Granata, Gerardo Botti, Michele Caraglia, Guglielmo Nasti, Paolo Muto Cancers, 2021
How radical prostatectomy procedures have changed over the last 10 years in Italy: a comparative analysis based on more than 1500 patients participating in the MIRROR-SIU/LUNA and the Pros-IT CNR study Mauro Gacci, Walter Artibani, Pierfrancesco Bassi, Filippo Bertoni, Sergio Bracarda, Alberto Briganti, Giorgio Carmignani, Luca Carmignani, Giario Conti, Renzo Corvò, Cosimo De Nunzio, Ferdinando Fusco, Pierpaolo Graziotti, Isabella Greco, Stefania Maggi, Stefano Maria Magrini, Vincenzo Mirone, Rodolfo Montironi, Giuseppe Morgia, Giovanni Muto, Marianna Noale, Stefano Pecoraro, Angelo Porreca, Umberto Ricardi, Elvio Russi, Giorgio Russo, Andrea Salonia, Alchiede Simonato, Sergio Serni, Davide Tomasini, Andrea Tubaro, Vittorina Zagonel, Gaetano Crepaldi, The MIRROR-SIU/LUNA Study Group, the Pros-IT CNR Study Group, Walter Artibani, Pierfrancesco Bassi, Sergio Bracarda, Giario Natale Conti, Renzo Corvò, Gaetano Crepaldi, Angelo Porreca, Pierpaolo Graziotti, Stefania Maggi, Vincenzo Mirone, Rodolfo Montironi, Marianna Noale, Elvio Russi, Filippo Bertoni, Mauro Gacci, Stefano Maria Magrini, Giovanni Muto, Stefano Pecoraro, Umberto Ricardi, Andrea Tubaro, Vittorina Zagonel, Anna Rita Alitto, Enrica Ambrosi, Alessandro Antonelli, Cynthia Aristei, Franco Bardari, Lilia Bardoscia, Salvina Barra, Sara Bartoncini, Umberto Basso, Carlotta Becherini, Rita Bellavita, Franco Bergamaschi, Stefania Berlingheri, Alfredo Berruti, Marco Borghesi, Roberto Bortolus, Valentina Borzillo, Davide Bosetti, Giuseppe Bove, Pierluigi Bove, Maurizio Brausi, Alessio Bruni, Giorgio Bruno, Eugenio Brunocilla, Alberto Buffoli, Michela Buglione, Consuelo Buttigliero, Giovanni Cacciamani, Michela Caldiroli, Giuseppe Cardo, Giorgio Carmignani, Giuseppe Carrieri, Emanuele Castelli, Elisabetta Castrezzati, Gianpiero Catalano, Susanna Cattarino, Francesco Catucci, Dario Cavallini Francolini, Ofelia Ceccarini, Antonio Celia, Francesco Chiancone, Tommaso Chini, Claudia Cianci, Antonio Cisternino, Devis Collura, Franco Corbella, Matteo Corinti, Paolo Corsi, Fiorenza Cortese, Luigi Corti, Nunzio deCosimo, Olga Cristiano, D’Angelillo Rolando, Luigi Da Pozzo, Daniele D’Agostino, Carolina D’Elia, Matteo Dandrea, Micheles De Angelis, Paolo De Angelis, Ottavio De Cobelli, Bernardino De Concilio, Antonello De Lisa, Stefano De Luca, Agostina De Stefani, Chiara Lucrezia Deantoni, Claudio Degli Esposti, Anna Destito, Beatrice Detti, Nadia Di Muzio, Andrea Di Stasio, Calogero Di Stefano, Danilo Di Trapani, Giuseppe Difino, Sara Falivene, Giuseppe Farullo, Paolo Fedelini, Ilaria Ferrari, Francesco Ferraù, Matteo Ferro, Andrei Fodor, Francesco Fontana, Francesco Francesca, Giulio Francolini, Paolo Frata, Giovanni Frezza, Pietro Gabriele, Maria Galeandro, Elisabetta Garibaldi, Pietro Giovanni Gennari, Alessandro Gentilucci, Alessandro Giacobbe, Laura Giussani, Giuseppe Giusti, Paolo Gontero, Alessia Guarneri, Cesare Guida, Alberto Gurioli, Dorijan Huqi, Ciro Imbimbo, Gianluca Ingrosso, Cinzia Iotti, Corrado Italia, Pierdaniele La Mattina, Roberto La Rocca, Enza Lamanna, Luciana Lastrucci, Grazia Lazzari, Fabiola Liberale, Giovanni Liguori, Roberto Lisi, Frank Lohr, Riccardo Lombardo, Jon AJ Lovisolo, Giuseppe Mario Ludovico, Nicola Macchione, Francesca Maggio, Michele Malizia, Gianluca Manasse, Giovanni Mandoliti, Giovanna Mantini, Luigi Marafioti, Luisa Marciello, Alberto Mario Marconi, Antonietta Martilotta, Salvino Marzano, Stefano Masciullo, Gloria Maso, Adele Massenzo, Ercole Mazzeo, Luigi Mearini, Serena Medoro, Rosa Molè, Giorgio Monesi, Emanuele Montanari, Franco Montefiore, Giampaolo Montesi, Giuseppe Morgia, Gregorio Moro, Giorgio Muscas, Daniela Musio, Paolo Muto, Giovanni Muzzonigro, Giorgio Napodano, Carlo Luigi Augusto Negro, Mattia Nidini, Maria Ntreta, Marco Orsatti, Carmela Palazzolo, Isabella Palumbo, Alessandro Parisi, Paolo Parma, Nicola Pavan, Martina Pericolini, Francesco Pinto, Antonio Pistone, Valerio Pizzuti, Angelo Platania, Caterina Polli, Giorgio 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The clinical and translational research activities at the INT – IRCCS “Fondazione Pascale” cancer center (Naples, Italy) during the COVID-19 pandemic and the INT-Pascale COVID-19 Crisis Unit, Franco M. Buonaguro, Gerardo Botti, Paolo Antonio Ascierto, Sandro Pignata, Franco Ionna, Paolo Delrio, Antonella Petrillo, Ernesta Cavalcanti, Maurizio Di Bonito, Sisto Perdonà, Michelino De Laurentiis, Francesco Fiore, Raffaele Palaia, Francesco Izzo, Stefania D’Auria, Virginia Rossi, Simona Menegozzo, Mauro Piccirillo, Egidio Celentano, Arturo Cuomo, Nicola Normanno, Maria Lina Tornesello, Rocco Saviano, Daniela Barberio, Luigi Buonaguro, Giovanni Giannoni, Paolo Muto, Leonardo Miscio, Attilio A. M. Bianchi Infectious Agents and Cancer, 2020
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The safety of atezolizumab plus chemotherapy for the treatment of metastatic lung cancer Anna Manzo, Guido Carillio, Agnese Montanino, Vincenzo Sforza, Giuliano Palumbo, Giovanna Esposito, Raffaele Costanzo, Claudia Sandomenico, Carmine La Manna, Nicola Martucci, Antonello La Rocca, Giuseppe De Luca, Maria Carmela Piccirillo, Rossella De Cecio, Gerardo Botti, Giuseppe Totaro, Paolo Muto, Carmine Picone, Nicola Normanno, Alessandro Morabito Expert Opinion on Drug Safety, 2020
Angiogenesis and epidermal growth factor receptor inhibitors in non-small cell lung cancer Giuliano Palumbo, Giovanna Giovanna Esposito, Guido Carillio, Anna Manzo, Agnese Montanino, Vincenzo Sforza, Raffaele Costanzo, Claudia Sandomenico, Carmine La Manna, Nicola Martucci, Antonello La Rocca, Giuseppe De Luca, Maria Carmela Piccirillo, Rossella De Cecio, Francesco Perrone, Giuseppe Totaro, Paolo Muto, Carmine Picone, Nicola Normanno, Alessandro Morabito Exploration of Targeted Anti Tumor Therapy, 2020
Treatment paths for localised prostate cancer in Italy: The results of a multidisciplinary, observational, prospective study (Pros-IT CNR) Michela Buglione, Marianna Noale, Alessio Bruni, Alessandro Antonelli, Filippo Bertoni, Renzo Corvo’, Umberto Ricardi, Paolo Borghetti, Marta Maddalo, Claudio Simeone, Ercole Mazzeo, Angelo Porreca, Sergio Serni, Pierfrancesco Bassi, Mauro Gacci, Vincenzo Mirone, Rodolfo Montironi, Andrea Tubaro, Alfredo Berruti, Giario Natale Conti, Stefania Maggi, Stefano Maria Magrini, Luca Triggiani, the Pros-IT CNR study group Plos One, 2019
Pain REduction with bone metastases STereotactic radiotherapy (PREST): A phase III randomized multicentric trial Francesco Cellini, Stefania Manfrida, Francesco Deodato, Savino Cilla, Ernesto Maranzano, Stefano Pergolizzi, Fabio Arcidiacono, Rossella Di Franco, Francesco Pastore, Matteo Muto, Valentina Borzillo, Costanza Maria Donati, Giambattista Siepe, Salvatore Parisi, Antonia Salatino, Antonino D’Agostino, Giampaolo Montesi, Anna Santacaterina, Vincenzo Fusco, Mario Santarelli, Maria Antonietta Gambacorta, Renzo Corvò, Alessio Giuseppe Morganti, Valeria Masiello, Paolo Muto, Vincenzo Valentini Trials, 2019
New paradigm for stage III melanoma: From surgery to adjuvant treatment Paolo Antonio Ascierto, Lorenzo Borgognoni, Gerardo Botti, Michele Guida, Paolo Marchetti, Simone Mocellin, Paolo Muto, Giuseppe Palmieri, Roberto Patuzzo, Pietro Quaglino, Ignazio Stanganelli, Corrado Caracò Journal of Translational Medicine, 2019
Pembrolizumab in lung cancer: Current evidence and future perspectives Giuliano Palumbo, Guido Carillio, Anna Manzo, Agnese Montanino, Vincenzo Sforza, Raffaele Costanzo, Claudia Sandomenico, Carmine La Manna, Giuseppe De Luca, Maria Carmela Piccirillo, Gennaro Daniele, Rossella De Cecio, Gerardo Botti, Giuseppe Totaro, Paolo Muto, Carmine Picone, Giovanna Esposito, Nicola Normanno, Alessandro Morabito Future Oncology, 2019
Disease-specific and general health-related quality of life in newly diagnosed prostate cancer patients: The Pros-IT CNR study the Pros-IT CNR study group, Angelo Porreca, Marianna Noale, Walter Artibani, Pier Francesco Bassi, Filippo Bertoni, Sergio Bracarda, Giario Natale Conti, Renzo Corvò, Mauro Gacci, Pierpaolo Graziotti, Stefano Maria Magrini, Vincenzo Mirone, Rodolfo Montironi, Giovanni Muto, Stefano Pecoraro, Umberto Ricardi, Elvio Russi, Andrea Tubaro, Vittorina Zagonel, Gaetano Crepaldi, Stefania Maggi Health and Quality of Life Outcomes, 2018
Radiosurgery and stereotactic radiotherapy with cyberknife system for meningioma treatment Rossella Di Franco, Valentina Borzillo, Vincenzo Ravo, Sara Falivene, Francesco Jacopo Romano, Matteo Muto, Fabrizio Cammarota, Giuseppe Totaro, Gianluca Ametrano, Sabrina Rossetti, Carla Cavaliere, Carmine D’ Aniello, Gelsomina Iovane, Maria Assunta Porricelli, Massimiliano Berretta, Gerardo Botti, Luigi Starace, Enrico La Salvia, Gaetano Facchini, Paolo Muto Neuroradiology Journal, 2018
Exploring the molecular aspects associated with testicular germ cell tumors: A review Gaetano Facchini, Sabrina Rossetti, Carla Cavaliere, Carmine D’Aniello, Rossella Di Franco, Gelsomina Iovane, Giovanni Grimaldi, Raffaele Piscitelli, Paolo Muto, Gerardo Botti, Sisto Perdonà, Bianca Maria Veneziani, Massimiliano Berretta, Micaela Montanari Oncotarget, 2018
Quality of life after prostate cancer diagnosis: Data from the Pros-IT CNR Mauro Gacci, Marianna Noale, Walter Artibani, Pier Francesco Bassi, Filippo Bertoni, Sergio Bracarda, Giario Natale Conti, Renzo Corvò, Pierpaolo Graziotti, Stefano Maria Magrini, Vincenzo Mirone, Rodolfo Montironi, Giovanni Muto, Stefano Pecoraro, Angelo Porreca, Umberto Ricardi, Elvio Russi, Andrea Tubaro, Vittorina Zagonel, Gaetano Crepaldi, Stefania Maggi European Urology Focus, 2017
Cyberknife® system: A new therapeutic strategy for sinonasal solitary extramedullary plasmacytoma Journal of Biological Regulators and Homeostatic Agents, 2017
Pros-IT CNR: an Italian prostate cancer monitoring project the Pros-IT CNR study group, Marianna Noale, Stefania Maggi, Walter Artibani, Pier Francesco Bassi, Filippo Bertoni, Sergio Bracarda, Giario Natale Conti, Renzo Corvò, Mauro Gacci, Pierpaolo Graziotti, Stefano Maria Magrini, Riccardo Maurizi Enrici, Vincenzo Mirone, Rodolfo Montironi, Giovanni Muto, Stefano Pecoraro, Angelo Porreca, Umberto Ricardi, Andrea Tubaro, Vittorina Zagonel, Filiberto Zattoni, Gaetano Crepaldi Aging Clinical and Experimental Research, 2017
Locally advanced paranasal sinus carcinoma: A study of 30 patients Francesco Perri, Raffaele Addeo, Manuel Conson, Adriana Faiella, Giuseppina Della Vittoria Scarpati, Gabriella Torre, Angela Di Biase, Paola Romanelli, Carlo Buonerba, Giuseppe Di Lorenzo, Antonio Daponte, Francesco Caponigro, Salvatore Pisconti, Roberto Pacelli, Vincenzo Ravo, Paolo Muto, Raffaele Solla Oncology Letters, 2017
External radiotherapy for breast cancer in the elderly Francesca Maria Giugliano, Sara Falivene, Emanuela Esposito, Rossella Di Franco, Matteo Muto, Massimiliano D’Aiuto, Paolo Muto Aging Clinical and Experimental Research, 2017
Rectal/urinary toxicity after hypofractionated vs. Conventional radiotherapy in high risk prostate cancer: Systematic review and meta analysis European Review for Medical and Pharmacological Sciences, 2017
Phase II clinical study of valproic acid plus cisplatin and cetuximab in recurrent and/or metastatic squamous cell carcinoma of Head and Neck-V-CHANCE trial Francesco Caponigro, Elena Di Gennaro, Franco Ionna, Francesco Longo, Corrado Aversa, Ettore Pavone, Maria Grazia Maglione, Massimiliano Di Marzo, Paolo Muto, Ernesta Cavalcanti, Antonella Petrillo, Fabio Sandomenico, Piera Maiolino, Roberta D’Aniello, Gerardo Botti, Rossella De Cecio, Nunzia Simona Losito, Stefania Scala, Annamaria Trotta, Andrea Ilaria Zotti, Francesca Bruzzese, Antonio Daponte, Ester Calogero, Massimo Montano, Monica Pontone, Gianfranco De Feo, Francesco Perri, Alfredo Budillon BMC Cancer, 2016
Axitinib after Sunitinib in metastatic renal cancer: Preliminary results from Italian "Real-World" SAX Study Carmine D'Aniello, Maria G. Vitale, Azzurra Farnesi, Lorenzo Calvetti, Maria M. Laterza, Carla Cavaliere, Chiara Della Pepa, Vincenza Conteduca, Anna Crispo, Ferdinando De Vita, Francesco Grillone, Enrico Ricevuto, Michele De Tursi, Rocco De Vivo, Marilena Di Napoli, Sabrina C. Cecere, Gelsomina Iovane, Alfonso Amore, Raffaele Piscitelli, Giuseppe Quarto, Salvatore Pisconti, Gennaro Ciliberto, Piera Maiolino, Paolo Muto, Sisto Perdonà, Massimiliano Berretta, Emanuele Naglieri, Luca Galli, Giacomo Cartenì, Ugo De Giorgi, Sandro Pignata, Gaetano Facchini, Sabrina Rossetti Frontiers in Pharmacology, 2016
Role of DNA repair machinery and p53 in the testicular germ cell cancer: A review Francesco Jacopo Romano, Sabrina Rossetti, Vincenza Conteduca, Giuseppe Schepisi, Carla Cavaliere, Rossella Di Franco, Elvira La Mantia, Luigi Castaldo, Flavia Nocerino, Gianluca Ametrano, Francesca Cappuccio, Gabriella Malzone, Micaela Montanari, Daniela Vanacore, Vincenzo Quagliariello, Raffaele Piscitelli, Maria Filomena Pepe, Massimiliano Berretta, Carmine D'Aniello, Sisto Perdonà, Paolo Muto, Gerardo Botti, Gennaro Ciliberto, Bianca Maria Veneziani, Francesco De Falco, Piera Maiolino, Michele Caraglia, Maurizio Montella, Ugo De Giorgi, Gaetano Facchini Oncotarget, 2016
Hypofractionated breast cancer radiotherapy. Helical tomotherapy in supine position or classic 3DConformal radiotherapy in prone position: Which is better? Anticancer Research, 2014
Management of painful bone metastases: Our experience according to scientific evidence on palliative radiotherapy Anticancer Research, 2014
Abscopal effects of radiotherapy on advanced melanoma patients who progressed after ipilimumab immunotherapy Antonio M Grimaldi, Ester Simeone, Diana Giannarelli, Paolo Muto, Sara Falivene, Valentina Borzillo, Francesca Maria Giugliano, Fabio Sandomenico, Antonella Petrillo, Marcello Curvietto, Assunta Esposito, Miriam Paone, Marco Palla, Giuseppe Palmieri, Corrado Caracò, Gennaro Ciliberto, Nicola Mozzillo, Paolo A Ascierto Oncoimmunology, 2014
Induction docetaxel-cisplatin followed by extended-field radiotherapy in patients with cervical metastases from unknown primary carcinoma Anticancer Research, 2013
Radiotherapy for the treatment of bone metastases Rossella Di Franco, Sara Falivene, Vincenzo Ravo, Paolo Muto Interventional Neuroradiology of the Spine Clinical Features Diagnosis and Therapy, 2013
Platelet gel in cutaneous radiation dermatitis Vincenzo Iervolino, Gaetano Di Costanzo, Rosa Azzaro, Anna Maria Diodato, Catia Addolorata Di Macchia, Tommaso Di Meo, Arnolfo Petruzziello, Giovanna Loquercio, Paolo Muto, Gaetano Apice, Carmela Cacciapuoti Supportive Care in Cancer, 2013
Phase I study of vinorelbine and paclitaxel in small-cell lung cancer Rosario Vincenzo Iaffaioli, Gaetano Facchini, Anna Tortoriello, Francesco Caponigro, Alfonso Illiano, Maria Gentile, Adriano Gravina, Paolo Muto, Rosario Vincenzo Iaffaioli Cancer Chemotherapy and Pharmacology, 1997
Intraoperative radiotherapy in gastric cancer: Therapeutic aspects Quaderni Di Medicina E Chirurgia, 1992
Radiotherapy in the treatment of orbital rhabdomyosarcoma Radiologia Medica, 1992
Primary role of the standard chest examination in the diagnosis of pulmonary microlithiasis in its initial phase. Apropos of 2 cases Radiologia Medica, 1988
Computed tomography for the diagnosis of desmoid tumors. Report of a case Italian Current Radiology, 1988
A bilateral mixed laryngocele: CT findings. Rays International Journal of Radiological Sciences, 1986
Tolerance of moving strip treatment after surgery and chemotherapy in the treatment of ovarian cancer, III stage (F.I.G.O.) Rays International Journal of Radiological Sciences, 1985
Cardiovascular effects of ionic and non-ionic contrast media during and after rapid sequence urography Rays International Journal of Radiological Sciences, 1985
Actual possibilities of radiotherapy of pulmonary tumors Rassegna Internazionale Di Clinica E Terapia, 1985
Radio-chemio-therapic association in juvenile alveolar rhabdomyosarcoma Rassegna Internazionale Di Clinica E Terapia, 1984
Glucagon in radiology Rassegna Internazionale Di Clinica E Terapia, 1984
