Angelo Colucci

Scopus Publications

A longitudinal comparative analysis of serum metabolomic signatures in children with SARS-CoV-2 infection and MIS-C
A. Lo Vecchio, V. Discepolo, L. Pierri, A. Catzola, M. Lombardi, A. Colucci, M. Poeta, E. Bruzzese, J. Troisi, A. Guarino
Communications Medicine, 2026
SARS-CoV-2 infection usually has a mild course in childhood, yet few children develop a Multisystem Inflammatory Syndrome (MIS-C). Several metabolic pathways have been found to be dysregulated in adults with COVID-19, yet data are lacking in children. Here we investigate serum metabolomic features of children with COVID-19 in relation to age, sex and both clinical and biochemical severity. We carried out a prospective observational comparative cohort study enrolling 92 children (48 M, mean age 3.69 ± 5.1 years) with acute SARS-CoV-2 infection and 7 with MIS-C along with 41 age- and sex-matched controls. Sera collected at admission, acute phase, discharge and remission were analyzed by Gas Chromatography Mass Spectroscopy. Here we identify a distinct signature featuring inflammation, reactive oxygen species and glicerolipids pathways in children with acute SARS-CoV-2 infection compared to controls (permutation test p = 0.0015). Metabolomic profile changes are associated with age, disease status and disease severity, while a normalization of these changes is observed at disease resolution. MIS-C children showed a unique signature compared to age-/sex-matched COVID-19 patients or controls. Pediatric COVID-19 has a characteristic metabolomic signature featuring glucose and aminoacid metabolism, that varies with age and disease phenotype. Our study supports the value of metabolomics to unveil pathways related to host-viral interaction that may also help identify early predictors of disease evolution. Lo Vecchio, Discepolo et al., characterize the serum metabolomic profiles of children with acute SARS-CoV-2 infection and multisystem inflammatory syndrome (MIS-C). Distinct metabolic signatures involving inflammation, oxidative stress, and lipid metabolism correlate with age and disease severity, associate with MIS-C as a unique metabolic phenotype and reverse upon recovery. After the COVID-19 pandemic, despite the wide-spread vaccination campaigns, we have been witnessing multiple surges of SARS-CoV-2 epidemics around the globe that, albeit less severe, are still contributing significantly to morbidity in the general population. Children are frequently affected, and in rare cases may develop a complication known as Multisystem Inflammatory Syndrome that may have a critical course. In this study we have investigated changes in blood metabolites resulting from the interaction between the SARS-CoV-2 and children, revealing that their variations are associated with age and disease severity. Our study could help identifying early markers that may predict disease evolution.
Exploring the mediterranean diet among medical students: A multicenter PREDIMED survey
Pietro Aliberti, Annalaura Giordano, Angelo Colucci, Marta Giovengo, Rossella Colantuono, Carmela Pia Senatore, Claudia Mandato
Clinical Nutrition Espen, 2026
BACKGROUND & AIMS: This study explored Mediterranean diet (MD) adherence, familiarity with dietary tools and exposure to nutrition-related topics among Italian medical students. METHODS: 1074 medical students participated in the study by completing the PREDIMED questionnaire. The questionnaire was administered via Google Form and distributed through social media. RESULTS: Only 40 participants (4%) reported familiarity with the PREDIMED or KIDMED questionnaires. Overall, moderate adherence to the MD was common (68%), particularly in the South (54%) and North (34%). High adherence was reported only by 20% of participants. Exposure to formal nutritional teaching was not associated with adherence to the MD. CONCLUSION: Adherence to the Mediterranean diet among Italian medical students was generally moderate, with significant differences according to geographic area and sex. No significant association emerged between exposure to nutrition-related teaching and adherence to the Mediterranean diet.
Body Mass Index Status in Italian Children with Celiac Disease at Diagnosis and After 12–18 Months on a Gluten-Free Diet: A Multicenter Retrospective Study
Alice Monzani, Elena Pozzi, Luisa Abbattista, Marco Crocco, Federica Malerba, Silvia Marcolin, Noemi Paggi, Monica Montuori, Giulia Gagliostro, Claudia Mandato, Angelo Colucci, Fernanda Cristofori, Ruggiero Francavilla, Giovanna Zuin, Sigi Petrela, Francesco Valitutti, Camilla Alberti, Francesco Graziano, Michele Citrano, Simona Spetrino, Elena Lionetti, Andrea Di Siena, Massimo Spina, Chiara Maria Trovato, Barbara Parma, Maurizio Mennini, Naire Sansotta, Enrico Felici, Pier Luigi Calvo, Maria Teresa Illiceto, Chiara Terzi, Federica Ferrari, Licia Pensabene, Lorenza Scotti, Renata Auricchio
Nutrients, 2026
Background/Objectives: The distribution of body mass index (BMI) categories at celiac disease (CD) diagnosis in children is changing, and the impact of a gluten-free diet (GFD) on BMI status remains incompletely understood. We aimed to evaluate the distribution of BMI categories at CD diagnosis and their changes after 12–18 months on a GFD in Italian children. Methods: Children and adolescents aged 0–18 years who received a new diagnosis of CD at 23 Pediatric Gastroenterology referral centers in Italy were retrospectively enrolled. We analyzed their BMI status at diagnosis, classifying them as underweight, normal weight, overweight, or obese. BMI changes were assessed after 12–18 months on a GFD. Results: Among the 4967 children (mean age 7.1 ± 4.1 years, M:F = 1827:3140), 4.4% were underweight, 77.5% normal weight, 12.7% overweight, and 5.4% obese at diagnosis. Overweight/obese children were more likely to have a family history of CD, associated conditions, and an asymptomatic presentation. After 12–18 months of GFD, 55.7% of underweight children achieved normal weight, and 23% of overweight/obese reverted to normal weight. Conversely, 10.9% of normal-weight children and 3.2% of underweight children became overweight/obese. Conclusions: At diagnosis, most children were normal weight, but 18.1% presented with overweight/obesity. After 12–18 months on a GFD, BMI normalized in over half of underweight but in fewer than one-quarter of overweight/obese subjects.
Reasons why treatment of metabolic dysfunction-associated steatotic liver disease may benefit from targeting the gut–liver axis as well
Claudia Mandato, Angelo Colucci, Pietro Vajro
United European Gastroenterology Journal, 2024
Dear Editor, We read with interest the article by Zeng et al. on the therapeutic management of metabolic dysfunction-associated steatotic liver disease (MASLD).1 While we commend the authors for the accurate work, we have a concern regarding the gut-liver axis (GLA) derangement, an important facet that has not been mentioned in the review. GLA is a multiple-hits' acknowledged pathogenetic component that is crucial in the development and progression of MASLD, and its modulation has been repeatedly considered as an attractive treatment strategy targeting the composite network of cross-talking between the gut, microbiome, and the liver through the portal circulation.2 Recently, aside from the long-standing experience with conventional pro-, pre-, and symbiotic treatment approaches,3 a number of novel-related options have emerged.2 In short, (a) in mice models and human steatotic liver, next-generation probiotics (single bacterial strains or multi-strain consortia), especially the mucin-degrading bacterium Akkermansia muciniphila, appear promising as targeted gut microbiota (GM)-based therapy effective in increasing the gut barrier function,4 (b) purposefully engineered probiotics show potential benefits as optimal vectors for producing specific beneficial molecules targeting several conditions including the steatotic liver, (c) fecal microbiota-transplantation (FMT)-related GM changes in a study were linked to improved histological necro-inflammatory score and liver biochemical profile and in another study, they were linked to decreased liver fat. Results from at least eight other FMT similar studies that are currently being developed are eagerly awaited.5 (d) Finally, mounting research indicates that some of the hepatic effects of bariatric surgery are also mediated by advantageous modifications in the GM composition. Overall, although GM-related treatments represent an area of ongoing research and development still requiring rigorous pharmacological studies and larger randomized controlled trials for moving from bench to bedside, we believe there are good reasons for mentioning them as possible tools warranting interest in the MASLD therapeutic arsenal. As noted by Zeng et al.,1 additional strong evidence is sorely needed also to better define the long-term benefits and drawbacks of still poorly investigated multiple combined medication regimen strategies on MASLD patients' health and well-being. Hence, combining the GLA with other pieces of this puzzle may prove an exciting area of exploration and innovation for better patient-centered care. Claudia Mandato: Conceptualization; project administration, supervision, writing—original draft, writing—editing and review. Angelo Colucci: Conceptualization, writing—original draft, writing—editing and review. Pietro Vajro: Conceptualization, writing—original draft, writing—editing and review. The authors declare no conflicts of interest. Data sharing is not applicable to this article as no new data were created or analyzed in this study.
Perceptions and Expectations of Youth Regarding the Respect for Their Rights in the Hospital
Roberta De Rosa, Maria Anna Siano, Angelo Colucci, Anna Giulia Elena De Anseris, Paolo Siani, Pietro Vajro, Giulia Savarese, Claudia Mandato
Children, 2024
Information obtained from children themselves regarding the characteristics of the ideal hospital that ensure well-being during a hospital stay is scarce. Here, we report the opinions, perceptions, and expectations of 700 children and adolescents about their experiences, assessed through a mixed-method research approach with age-appropriate questionnaires, three open-ended questions, and an analysis of optional pictorial and textual narratives. Most children indicated that, while they acknowledged the expertise of hospital staff, they also noted several shortcomings, e.g., insufficiently understandable medical information as well as emotional and cognitive support. The continuity of schooling and the right to suffer as little as possible were also critical issues. Adolescents valued in particular the quality of care and services provided, the hospital’s adherence to equality and non-discrimination rights, and protection systems but negatively perceived several aspects related to play and participation. Significant differences in the co-occurrences of the most frequently used text terms with the keywords “hospital” and “child/adolescent” between age groups highlight variations in the way patients perceive and articulate their experiences within the hospital setting depending on the cognitive processes linked to age. In drawings, prevailing attention was placed on the physical context of the hospital room, with figures expressing mostly negative emotions. Specifically, in this regard, the main emotion in children was sadness, and, in adolescents, it was fear. Overall, these insights are pivotal in the context of our research objectives as they shed light on the nuanced preferences, needs, and perspectives of children and adolescents during their hospital stays. Recognizing the identified shortcomings, we propose recommendations emphasizing the improvement of medical communication clarity, enhancement of emotional and cognitive support, and the improvement of programs to avoid instructional gaps during hospital stays. Addressing these specific needs is critical for a more comprehensive approach to pediatric healthcare provision.
Emerging, re-emerging and/or atypically behaving infectious diseases
Claudia Mandato, Angelo Colucci, Pietro Vajro
Acta Paediatrica International Journal of Paediatrics, 2023
The 3rd millennium started with an outbreak of severe acute respiratory syndrome (SARS) caused by the coronavirus SARS CoV-1, identified in late February 2003 in China, and then spreading in almost all continents. That was just the beginning of a series of outbreaks and epidemics determined by several emerging, re-emerging and/or atypically behaving infectious agents. Just a few years after SARS CoV-1 we have witnessed the first influenza pandemic of the 21st century due to the outbreak of a swine-derived influenza A virus (H1N1) that spread quickly and was declared a full-scale pandemic from the World Health Organisation (WHO) in June 2009. After the 2014–2016 rapidly evolving outbreak of Ebola in the West African subregion, we have now entered the present era of coronavirus-SARS-CoV-2, a virus sharing more than 70% genetic similarity to SARS-CoV-1, at the origin of COVID-19. To complicate matters, the persistence of Covid-19 has facilitated the rise of a number of common diseases which had been suppressed by social restrictions during the pandemic peaks and are now coming back along with the return to pre-lockdown life. Changes in contact patterns since early 2020 have, indeed, affected not only the number of outbreaks but also the regular seasonal cycles of diseases such as the seasonal flu/influenza.1 The 2020 and 2021 winter flu season was among the mildest reported in terms of deaths and/or hospitalizations. Instead, many cases were registered in February and continued to go up into the spring and summer as Covid restrictions and adoption of non-pharmaceutical interventions were alleviated.2 The current 2022–23 flu season has been marked by unprecedented unpredictability and a higher-than-usual volume of cases.3 Most of these diseases have often emerged also in new and peculiar ways. As paediatricians, we are called upon as small children are those who do appear more involved, likely because of their missed age-related opportunities to acquire antibodies against common viruses.1 Similarly to the seasonal influenza, also respiratory syncytial virus (RSV) seemed to disappear in 2020–2021. However, it come back with an irregular viral behaviour during the off-season spring and summer of last year overfilling many children's hospitals during fall adding to influenza and COVID this year with a so called “tripledemic” phenomenon. Small children have been the target also of a multi-country increased incidence of invasive Group A Streptococcus infection,4 and, in India, this age group has been victim of an infectious disease with a still debated aetiology, known as “tomato flu”. On top of the above scenarios of emerging and re-emerging, prevalently viral, irregularly behaving infectious diseases, beginning late 2021, and peaking in April 2022 in the UK, multiple clusters of severe non-A to E acute hepatitis have been documented worldwide in otherwise healthy young children. As of September 14, 2022, approximately 1296 probable cases have been reported from 37 countries/regions, of which approximately 55 required or received liver transplantation and 29 died.5 Although several etiopathogenetic and/or contributing factors have been called into question, the exact cause of this serious disease is still debated (hence, its name Childhood Severe Acute Hepatitis of Unknown Origin, AHUO). (Figure 1). The parallel silent outbreaks of adenovirus type F 41, a virus which has been found alone or accompanied by a variety of other common viruses in more than half of the AHOU cases, appear to represent more and more a major culprit. In a pre-Covid retrospective study this virus generally deemed responsible of benign, self-limiting illnesses with flu-like and gastrointestinal mild symptoms, has been found to provoke also a previously oversighted frequent mild liver injury which were also occasionally severe in particular when associated with a diverse coinfecting virus.6 The obvious question arises therefore why Adenovirus is now involved in so many simultaneous worldwide outbreaks of severe hepatitis in healthy children during this Covid period. The article by Irena Ilic and Milena Ilic appearing in this issue of Acta Paediatrica7 is particularly welcome because of their accurate review. The Authors are to be commended as they succeeded in focusing clearly on those which presently appear the most relevant epidemiological characteristics of the disease and individuating several related open questions needing urgent answers (Table 1). Regarding the etiological agents, although the most possible causes were also keenly considered, few more considerations regarding Adenovirus and its inclusion within the SARS-CoV-2 related immune debt/gap model may warrant further emphasis. No matter what, SARS-CoV-2 appears in fact to play or having played some relevant role. Ilic and Ilic appraisal provide several arguments that -put together- overall tend to support the hypothesis that the periods of reduced infectious exposure due to the previous rigid isolation associated with the COVID pandemic, after the aperture has resulted in an immunity gap in children leading to an increased susceptibility to/severity of one or more infectious agents.1 Past or present infection with SARS-CoV-2 might result in an altered host response to generally benign infectious agents, resulting in more severe inflammation damaging the liver in relation with the Adenovirus infection found in most reported series of severe AHUO, and in agreement with recent reports of an increasing circulation of Adenovirus in several countries, In some cases HAdV-F40/41 has been detected in patients having the same sequences from wastewater (F41 lineage 2b) and patients' homologous genome sequences.8 Most of the UK children presenting with severe AHUO the adenoviral infection was accompanied by an adeno-associated virus 2 (AAV2) in the liver. Much interestingly, these patients were also carriers of the DRB1*04:01 HLA allele, an immune phenotype typical of some autoimmune diseases. This supports the hypothesis that a specific genetic background of an immunological predisposition is probably at the basis of an exaggerated inflammatory response responsible for the viral acute liver damage. It has also been suggested the possible role of a multisystem inflammatory syndrome resulting from T-cell immune activation triggered by a superantigen motif contained inside the spike protein of SARS-CoV-2. As the Covid virus may persist in the gastrointestinal tract, superantigens released from the damaged mucosal barrier might increase the susceptibility to an unusual even more severe liver damage from Adenovirus alone or accompanied by other pathogens which have a similar intestinal tropism. Regarding the involvement of other possible causes, for mycotoxins or the administration of paracetamol, fluconazole which has been found to be excessive in some cases there is no effective evidence that they are associated with the disease.9 Last but not least, the greater awareness per se along with the post-COVID pandemic increased surveillance of public health issues, might have contributed to make diagnosis of some outbreaks more common. In other words, AHUO could not really be more common than in the past, but it's that more attention is being paid to it. In all cases, as for some other post-COVID conditions, also AHUO seems to be experiencing a spontaneous decrease so that some national surveillance systems are lowering their guard. Since the late autumn the major international health agencies have not presented new official statistics. Based on the CDC data on persons who are under investigation in the US the most recent document of the American Academy of Paediatrics, however, has reported that as of January 18, 2023, there have been no additional deaths reported since February 2022, and the proportion of patients requiring liver transplants has gone down from 15 percent to 9 percent since May 5.10 After the above considerations being made, one can agree that the present emergence of new epidemics is part of a never-ending and mostly cyclical phenomenon. The COVID epidemic in a naïve population has been followed by the development of herd/vaccine immunity, the subsequent disappearance of the epidemic, the gradual loss of immunity, and peaks of reappearance. As recommended by investigators of the European Paediatric Association/Union of National European Paediatric Societies and Associations, in any case, further studies are warranted to determine the potential for synergistic and antagonistic interactions of the various pathogens with SARSCoV-2 and their impact on the severity of clinical presentations or circulatory patterns when social distancing measures are mitigated. Hopefully, all this will allow for the establishment of appropriate prevention programs by public health systems and the acquisition of appropriate skills by us paediatricians to adequately address possible future epidemiological variations of even those which are considered the most common infectious diseases.11 In this context, the morbidity of the (putatively Adenovirus-linked) severe AHOU which at this moment, is tending to decrease, should not be ignored. As a disease with an aetiology and pathogenesis that remain unclear, no one knows when and where other outbreaks of this hepatitis will occur again in the future. Should the AHUO reappear, early diagnosis and prompt referral to centers with available liver transplantation facilities are in any case crucial due to possible deaths caused by the liver failure.12 There is no conflict of interest regarding this manuscript.
Multiple Sclerosis—Related Dietary and Nutritional Issues: An Updated Scoping Review with a Focus on Pediatrics
Claudia Mandato, Angelo Colucci, Roberta Lanzillo, Annamaria Staiano, Elena Scarpato, Luigi Schiavo, Francesca Felicia Operto, Maria Rosaria Serra, Cristina Di Monaco, Julia Sara Napoli, Grazia Massa, Pietro Vajro
Children, 2023
Purpose. Lifestyle/dietetic habits play an important role in the development and progression of multiple sclerosis (MS) disease. Here, we examine the basic pathomechanisms underlying intestinal and brain barrier modifications in MS and consider diets and dietary supplementations proposed over time to complement pharmacological therapies for improving disease outcome both in adults and in children. Methods. Scoping literature search about evidence-based findings in MS-related gut-brain axis (GBA) pathophysiology and nutritional issues at all ages. Findings. Data show that (1) no universal best diet exists, (2) healthy/balanced diets are, however, necessary to safeguard the adequate intake of all essential nutrients, (3) diets with high intakes of fruits, vegetables, whole grains, and lean proteins that limit processed foods, sugar, and saturated fat appear beneficial for their antioxidant and anti-inflammatory properties and their ability to shape a gut microbiota that respects the gut and brain barriers, (4) obesity may trigger MS onset and/or its less favorable course, especially in pediatric-onset MS. Vitamin D and polyunsaturated fatty acids are the most studied supplements for reducing MS-associated inflammation. Conclusions. Pending results from other and/or newer approaches targeting the GBA (e.g., pre- and probiotics, engineered probiotics, fecal-microbiota transplantation), accurate counseling in choosing adequate diet and maintaining physical activity remains recommended for MS prevention and management both in adults and children.
Vitamin D Levels in the Pre- and Post-COVID-19 Pandemic Periods and Related Confinement at Pediatric Age
Caterina Mosca, Angelo Colucci, Fabio Savoia, Camilla Calì, Margherita Del Bene, Giusy Ranucci, Antonio Maglione, Angela Pepe, Annalisa Morelli, Pietro Vajro, Claudia Mandato
Nutrients, 2023
Coronavirus disease 2019 (COVID-19) restrictions have been correlated with vitamin D deficiency in children, but some uncertainties remain. We retrospectively studied vitamin 25-(OH) D blood levels in 2182 Italian children/adolescents hospitalized for various chronic diseases in the year before (n = 1052) and after (n = 1130) the nationwide lockdown. The type of underlying disease, gender, and mean age (91 ± 55 and 91 ± 61 months, respectively) of patients included in the two periods were comparable. Although mean levels were the same (p = 0.24), deficiency status affected a significantly higher number of subjects during the lockdown period than in the pre-COVID period (p = 0.03), particularly in summer (p = 0.02), and there was also a smoothing of seasonal variations in vitamin D levels. Particularly at risk were males (OR = 1.22; p = 0.03), the 1–5 year age group (OR = 1.57; p < 0.01) and the 6–12 year age group (OR = 1.30; p = 0.04). Infants appeared not to be affected (p = 1.00). In the post-COVID period, the risk of vitamin D deficiency was unchanged in disease-specific groups. However, the proportion of deficiency or severe deficiency differed significantly in the subgroup with endocrinopathy (higher; Chi-square p = 0.04), and with respiratory problems and obesity (lower; Chi-square p = 0.01 and p < 0.01, respectively). Conflicting/opposite literature results advocate for further studies to clearly indicate the need for supplementation during possible future periods of confinement.
Case Report: Add-on treatment with odevixibat in a new subtype of progressive familial intrahepatic cholestasis broadens the therapeutic horizon of genetic cholestasis
Angela Pepe, Angelo Colucci, Martina Carucci, Lucia Nazzaro, Cristina Bucci, Giusy Ranucci, Angelo Di Giorgio, Pietro Vajro, Claudia Mandato
Frontiers in Pediatrics, 2023
Odevixibat, an ileal bile acid transporter (IBAT) inhibitor, is effective for the treatment of pruritus in children diagnosed with progressive familial intrahepatic cholestasis (PFIC) type 1 and 2. There are no studies showing the efficacy of Odevixibat in children with different subtypes of PFIC. We describe the case of a 6-year-old girl with chronic cholestatic jaundice. In the last 12 months laboratory data showed high serum levels of bilirubin (total bilirubin x 2.5 ULN; direct bilirubin x 1.7 ULN) and bile acids (sBA x 70 ULN), elevated transaminases (x 3–4 ULN), and preserved synthetic liver function. Genetic testing showed homozygous mutation in ZFYVE19 gene, which is not included among the classic causative genes of PFIC and determined a new non-syndromic phenotype recently classified as PFIC9 (OMIM # 619849). Due to the persistent intensity of itching [score of 5 (very severe) at the Caregiver Global Impression of Severity (CaGIS)] and sleep disturbances not responsive to rifampicin and ursodeoxycholic acid (UDCA), Odevixibat treatment was started. After treatment with odevixibat we observed: (i) reduction in sBA from 458 to 71 μmol/L (absolute change from baseline: −387 μmol/L), (ii) reduction in CaGIS from 5 to 1, and (iii) resolution of sleep disturbances. The BMI z-score progressively increased from −0.98 to +0.56 after 3 months of treatment. No adverse drug events were recorded. Treatment with IBAT inhibitor was effective and safe in our patient suggesting that Odevixibat may be potentially considered for the treatment of cholestatic pruritus also in children with rare subtypes of PFIC. Further studies on a larger scale could lead to the increasing of patients eligible for this treatment.
Placental Metabolomics of Fetal Growth Restriction
Jacopo Troisi, Steven J. K. Symes, Martina Lombardi, Pierpaolo Cavallo, Angelo Colucci, Giovanni Scala, David C. Adair, Maurizio Guida, Sean M. Richards
Metabolites, 2023
Fetal growth restriction is an obstetrical pathological condition that causes high neonatal mortality and morbidity. The mechanisms of its onset are not completely understood. Metabolites were extracted from 493 placentas from non-complicated pregnancies in Hamilton Country, TN (USA), and analyzed by gas chromatography–mass spectrometry (GC–MS). Newborns were classified according to raw fetal weight (low birth weight (LBW; <2500 g) and non-low birth weight (Non-LBW; >2500 g)), and according to the calculated birth weight centile as it relates to gestational age (small for gestational age (SGA), large for gestational age (LGA), and adequate for gestational age (AGA)). Mothers of LBW infants had a lower pre-pregnancy weight (66.2 ± 17.9 kg vs. 73.4 ± 21.3 kg, p < 0.0001), a lower body mass index (BMI) (25.27 ± 6.58 vs. 27.73 ± 7.83, p < 0.001), and a shorter gestation age (246.4 ± 24.0 days vs. 267.2 ± 19.4 days p < 0.001) compared with non-LBW. Marital status, tobacco use, and fetus sex affected birth weight centile classification according to gestational age. Multivariate statistical comparisons of the extracted metabolomes revealed that asparagine, aspartic acid, deoxyribose, erythritol, glycerophosphocholine, tyrosine, isoleucine, serine, and lactic acid were higher in both SGA and LBW placentas, while taurine, ethanolamine, β-hydroxybutyrate, and glycine were lower in both SGA and LBW. Several metabolic pathways are implicated in fetal growth restriction, including those related to the hypoxia response and amino-acid uptake and metabolism. Inflammatory pathways are also involved, suggesting that fetal growth restriction might share some mechanisms with preeclampsia.
The complexity of diagnosing a drug reaction syndrome in the child
Angela Pepe, Angelo Colucci, Lucia Nazzaro
Quaderni ACP, 2022
Malnutrition in pediatric chronic cholestatic disease: An up-to-date overview
Maria Tessitore, Eduardo Sorrentino, Giuseppe Schiano Di Cola, Angelo Colucci, Pietro Vajro, Claudia Mandato
Nutrients, 2021
Microbiome signatures of progression toward celiac disease onset in at-risk children in a longitudinal prospective cohort study
Maureen M. Leonard, Francesco Valitutti, Hiren Karathia, Meritxell Pujolassos, Victoria Kenyon, Brian Fanelli, Jacopo Troisi, Poorani Subramanian, Stephanie Camhi, Angelo Colucci, Gloria Serena, Salvatore Cucchiara, Chiara Maria Trovato, Basilio Malamisura, Ruggiero Francavilla, Luca Elli, Nur A. Hasan, Ali R. Zomorrodi, Rita Colwell, Alessio Fasano, Monica Montuori, Pasqua Piemontese, Angela Calvi, Mariella Baldassarre, Lorenzo Norsa, Celeste Lidia Raguseo, Tiziana Passaro, Paola Roggero, Marco Crocco, Annalisa Morelli, Michela Perrone, Naire Sansotta, Marcello Chieppa, Giovanni Scala, Maria Elena Lionetti, Carlo Catassi, Adelaide Serretiello, Corrado Vecchi, Gemma Castillejo de Villsante, and
Proceedings of the National Academy of Sciences of the United States of America, 2021
Noninvasive screening for congenital heart defects using a serum metabolomics approach
Jacopo Troisi, Pierpaolo Cavallo, Sean Richards, Steven Symes, Angelo Colucci, Laura Sarno, Annamaria Landolfi, Giovanni Scala, David Adair, Carla Ciccone, Giuseppe M. Maruotti, Pasquale Martinelli, Maurizio Guida
Prenatal Diagnosis, 2021
A serum metabolomic signature for the detection and grading of bladder cancer
Jacopo Troisi, Angelo Colucci, Pierpaolo Cavallo, Sean Richards, Steven Symes, Annamaria Landolfi, Giovanni Scala, Francesco Maiorino, Alfonso Califano, Marco Fabiano, Gianmarco Silvestre, Federica Mastella, Alessandro Caputo, Antonio D’Antonio, Vincenzo Altieri
Applied Sciences Switzerland, 2021
Untargeted metabolomics as a diagnostic tool in NAFLD: discrimination of steatosis, steatohepatitis and cirrhosis
Mario Masarone, Jacopo Troisi, Andrea Aglitti, Pietro Torre, Angelo Colucci, Marcello Dallio, Alessandro Federico, Clara Balsano, Marcello Persico
Metabolomics, 2021
Pediatric vs. adult NAFLD to MAFLD transition: a welcome but tangled path
Angelo Colucci, Maria Chiara Rocco, Anna Giulia Elena De Anseris, Lucia Nazzaro, Pietro Vajro, Claudia Mandato
Exploration of Medicine, 2021
Salivary and urinary metabolome in pediatric obesity and metabolic syndrome
Jacopo Troisi, Francesca Marciano, Giovanni Scala, Elizabeth Plunk, Luca Pierri, Angelo Colucci
Obesity and Diabetes Scientific Advances and Best Practice, 2020
Multi-omics analysis reveals the influence of genetic and environmental risk factors on developing gut microbiota in infants at risk of celiac disease
Maureen M. Leonard, Hiren Karathia, Meritxell Pujolassos, Jacopo Troisi, Francesco Valitutti, Poorani Subramanian, Stephanie Camhi, Victoria Kenyon, Angelo Colucci, Gloria Serena, Salvatore Cucchiara, Monica Montuori, Basilio Malamisura, Ruggiero Francavilla, Luca Elli, Brian Fanelli, Rita Colwell, Nur Hasan, Ali R. Zomorrodi, Alessio Fasano, Pasqua Piemontese, Angela Calvi, Mariella Baldassarre, Lorenzo Norsa, Chiara Maria Trovato, Celeste Lidia Raguseo, Tiziana Passaro, Paola Roggero, Marco Crocco, Annalisa Morelli, Michela Perrone, Marcello Chieppa, Giovanni Scala, Maria Elena Lionetti, Carlo Catassi, Adelaide Serretiello, Corrado Vecchi, Gemma Castillejo de Villsante, and
Microbiome, 2020
Metabolomics in genetic testing
Jacopo Troisi, Pierpaolo Cavallo, Angelo Colucci, Luca Pierri, Giovanni Scala, Steven Symes, Carter Jones, Sean Richards
Advances in Clinical Chemistry, 2020
Serum metallome in pregnant women and the relationship with congenital malformations of the central nervous system: A case-control study
Jacopo Troisi, Luigi Giugliano, Laura Sarno, Annamaria Landolfi, Sean Richards, Steven Symes, Angelo Colucci, Giuseppe Maruotti, David Adair, Marco Guida, Pasquale Martinelli, Maurizio Guida
BMC Pregnancy and Childbirth, 2019
Cardiac rehabilitation increases SIRT1 activity and β -Hydroxybutyrate levels and decreases oxidative stress in patients with HF with preserved ejection fraction
Graziamaria Corbi, Valeria Conti, Jacopo Troisi, Angelo Colucci, Valentina Manzo, Paola Di Pietro, Maria Consiglia Calabrese, Albino Carrizzo, Carmine Vecchione, Nicola Ferrara, Amelia Filippelli
Oxidative Medicine and Cellular Longevity, 2019
Metabolomic salivary signature of pediatric obesity related liver disease and metabolic syndrome
Jacopo Troisi, Federica Belmonte, Antonella Bisogno, Luca Pierri, Angelo Colucci, Giovanni Scala, Pierpaolo Cavallo, Claudia Mandato, Antonella Di Nuzzi, Laura Di Michele, Anna Delli Bovi, Salvatore Guercio Nuzio, Pietro Vajro
Nutrients, 2019
Therapeutic faecal microbiota transplantation controls intestinal inflammation through IL10 secretion by immune cells
Claudia Burrello, Federica Garavaglia, Fulvia Milena Cribiù, Giulia Ercoli, Gianluca Lopez, Jacopo Troisi, Angelo Colucci, Silvia Guglietta, Sara Carloni, Simone Guglielmetti, Valentina Taverniti, Giulia Nizzoli, Silvano Bosari, Flavio Caprioli, Maria Rescigno, Federica Facciotti
Nature Communications, 2018
Placental tissue metabolome analysis by GC-MS: Oven-drying is a viable sample preparation method
Jacopo Troisi, Steven Symes, David Adair, Angelo Colucci, Sonia Elisa Prisco, Carmen Imma Aquino, Immacolata Vivone, Maurizio Guida, Sean Richards
Preparative Biochemistry and Biotechnology, 2018
Malignant Mesothelioma of Spermatic Cord in an Elderly Man with a History of Asbestos Exposure
Antonio D'Antonio, Federica Mastella, Angelo Colucci, Gianmarco Silvestre
Urology, 2016

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