Prothrombin time predicts steroid response in severe alcohol-related hepatitis Claudia Tarli, Sergio Mannucci, Michele Vecchione, Mariangela Antonelli, Luisa Sestito, Francesco Antonio Mancarella, Alberto Tosoni, Tommaso Dionisi, Valeria Maccauro, Giovanna Di Sario, Patrizia Burra, Giacomo Germani, Antonio Gasbarrini, Giovanni Addolorato Liver International, 2024 Background and AimsAlcohol‐related hepatitis (AH) is the most severe form of acute alcohol‐related liver disease. Maddrey's discriminant function ≥32 defines the severe form of AH, which is associated with a high mortality. Steroid therapy represents the main medical treatment that may reduce short‐term mortality. Lille score at day 7 assesses the therapeutic response to steroid therapy. At present, no parameters able to predict the response to steroid therapy have been highlighted. The aim of the present study was to evaluate if baseline prothrombin time (BPT) could predict the response to steroid in severe AH (sAH).MethodsPatients consecutively admitted in two Italian Liver Units, from 2017 to 2022, suffering from sAH were included. Data were collected prospectively. In order to evaluate if BPT could predict steroid response, we assessed the correlation between BPT using the Lille score at day 7.ResultsA total of 52 patients received steroid treatment were enrolled in the study. The response to therapy was assessed by Lille score at day 7. Responders were 34 patients (65%), non‐responders 18 patients (34%). BPT significantly predicted the steroid response (p < .001). The likelihood of not responding to the steroid therapy was significantly higher in patients with higher BPT (OR = 2.954).ConclusionsBPT value predicted steroid response in patients with sAH. BPT could quickly identify non‐responder patients to steroid therapy, reducing the risk of infections and it could allow the early evaluation for liver transplantation.
Coffee and Microbiota: A Narrative Review Federico Rosa, Benedetta Marigliano, Sergio Mannucci, Marcello Candelli, Gabriele Savioli, et al. Current Issues in Molecular Biology, 2024 Coffee is one of the most widely consumed beverages in the world, which has important repercussions on the health of the individual, mainly because of certain compounds it contains. Coffee consumption exerts significant influences on the entire body, including the gastrointestinal tract, where a central role is played by the gut microbiota. Dysbiosis in the gut microbiota is implicated in the occurrence of numerous diseases, and knowledge of the microbiota has proven to be of fundamental importance for the development of new therapeutic strategies. In this narrative review, we thoroughly investigated the link between coffee consumption and its effects on the gut microbiota and the ensuing consequences on human health. We have selected the most significant articles published on this very interesting link, with the aim of elucidating the latest evidence about the relationship between coffee consumption, its repercussions on the composition of the gut microbiota, and human health. Based on the various studies carried out in both humans and animal models, it has emerged that coffee consumption is associated with changes in the gut microbiota, although further research is needed to understand more about this link and the repercussions for the whole organism.
Gut Microbiota, LADA, and Type 1 Diabetes Mellitus: An Evolving Relationship Andrea Piccioni, Federico Rosa, Sergio Mannucci, Federica Manca, Giuseppe Merra, Sabrina Chiloiro, Marcello Candelli, Marcello Covino, Antonio Gasbarrini, Francesco Franceschi Biomedicines, 2023 There is much evidence confirming the crucial role played by the gut microbiota in modulating the immune system in the onset of autoimmune diseases. In this article, we focus on the relationship between alterations in the microbiome and the onset of diabetes mellitus type 1 and LADA, in light of the latest evidence. We will then look at both how the role of the gut microbiota appears to be increasingly crucial in the pathogenesis of these disorders and how this aspect may be instrumental in the development of new potential therapeutic strategies that modulate the gut microbiota, such as probiotics, prebiotics, and fecal microbiota transplantation.
Risk of burnout and stress in physicians working in a COVID team: A longitudinal survey Tommaso Dionisi, Luisa Sestito, Claudia Tarli, Mariangela Antonelli, Alberto Tosoni, Stefano D’Addio, Antonio Mirijello, Gabriele Angelo Vassallo, Lorenzo Leggio, Antonio Gasbarrini, Giovanni Addolorato, Valeria Abbate, Nicola Acampora, Fabiana Agostini, Maria E. Ainora, Elena Amato, Gloria Andriollo, Brigida E Annicchiarico, Gabriele Antonucci, Alessandro Armuzzi, Christian Barillaro, Fabiana Barone, Rocco D. A. Bellantone, Daniela Belella, Andrea Bellieni, Andrea Benicchi, Francesca Benvenuto, Filippo Berloco, Roberto Bernabei, Antonio Bianchi, Luigi M. Biasucci, Stefano Bibbò, Federico Biscetti, Nicola Bonadia, Alberto Borghetti, Giulia Bosco, Silvia Bosello, Vincenzo Bove, Giulia Bramato, Vincenzo Brandi, Dario Bruno, Maria C. Bungaro, Alessandro Buonomo, Maria Livia Burzo, Angelo Calabrese, Andrea Cambieri, Giulia Cammà, Marcello Candelli, Gennaro Capalbo, Lorenzo Capaldi, Esmeralda Capristo, Luigi Carbone, Silvia Cardone, Angelo Carfì, Annamaria Carnicelli, Claudia Carnuccio, Cristiano Caruso, Francesco Antonio Casciaro, Lucio Catalano, Roberto Cauda, Andrea L Cecchini, Lucia Cerrito, Michele Ciaburri, Rossella Cianci, Sara Cicchinelli, Arturo Ciccullo Francesca Ciciarello, Antonella Cingolani, Maria C. Cipriani, Gaetano Coppola, Andrea Corsello, Federico Costante, Marcello Covino, Alessia D'Alessandro, Maria E. D'Alfonso, Emanuela D'Angelo, Marco D'Angelo, Francesca D'Aversa, Alessandro D'Errico, Fernando Damiano, Tommaso De Cunzo, Giuseppe De Matteis, Martina De Siena, Francesco De Vito, Valeria Del Gatto, Paola Del Giacomo, Fabio Del Zompo, Davide Antonio Della Polla, Elisabetta Del Sordo, Luca Di Gialleonardo, Simona Di Giambenedetto, Roberta Di Luca, Luca Di Maurizio, Alex Dusina, Alessandra Esperide, Domenico Faliero, Cinzia Falsiroli, Massimo Fantoni, Annalaura Fedele, Daniela Feliciani, Daniele Ferrarese, Andrea Flex, Evelina Forte, Francesco Franceschi, Laura Franza, Barbara Funaro, Mariella Fuorlo, Domenico Fusco, Maurizio Gabrielli, Eleonora Gaetani, Antonella Gallo, Giovanni Gambassi, Matteo Garcovich, Irene Gasparrini, Silvia Gelli, Antonella Giampietro, Laura Gigante, Gabriele Giuliano, Giorgia Giuliano, Bianca Giupponi, Elisa Gremese, Caterina Guidone, Amerigo Iaconelli, Angela Iaquinta, Michele Impagnatiello, Riccardo Inchingolo, Raffaele Iorio, Immacolata M Izzi, Cristina Kadhim, Daniele I. La Milia, Francesco Landi, Giovanni Landi, Rosario Landi, Massimo Leo, Antonio Liguori, Rosa Liperoti, Marco M. Lizzio, Maria R. Lo Monaco, Pietro Locantore, Francesco Lombardi, Loris Lopetuso, Valentina Loria, Angela R. Losito, Noemi Macerola, Giuseppe Maiuro, Francesco Mancarella, Francesca Mangiola, Alberto Manno, Sergio Mannucci, Debora Marchesini, Giuseppe Marrone, Ilaria Martis, Anna M. Martone, Emanuele Marzetti, Maria V. Matteo, Luca Miele, Alessio Migneco, Irene Mignini, Alessandro Milani, Domenico Milardi, Massimo Montalto, Flavia Monti, Davide Moschese, Barbara P. L. Mothaenje, Celeste A. Murace, Rita Murri, Marco Napoli, Elisabetta Nardella, Gerlando Natalello, Simone M. Navarra, Antonio Nesci, Maria Anna Nicolazzi, Alberto Nicoletti, Tommaso Nicoletti, Rebecca Nicolò, Nicola Nicolotti, Enrico C. Nista, Eugenia Nuzzo, Veronica Ojetti, Francesco C Pagano, Cristina Pais, Maria Pallozzi, Alfredo Papa, Luigi G. Papparella, Mattia Paratore, Giuseppe Parrinello, Giovanni Pecorini, Simone Perniola, Erika Pero, Claudia Petito, Luca Petricca, Martina Petrucci, Chiara Picarelli, Andrea Piccioni, Giulia Pignataro, Raffaele Pignataro, Marco Pizzoferrato, Fabrizio Pizzolante, Roberto Pola, Caterina Policola, Maurizio Pompili, Valerio Pontecorvi, Francesca R. Ponziani, Valentina Popolla, Enrica Porceddu, Angelo Porfidia, Giuseppe Privitera, Daniela Pugliese, Gabriele Pulcini, Simona Racco, Francesca Raffaelli, Gian L. Rapaccini, Luca Richeldi, Emanuele Rinninella, Sara Rocchi, Stefano Romano, Federico Rosa, Laura Rossi, Raimondo Rossi, Enrica Rossini, Elisabetta Rota, Fabiana Rovedi, Gabriele Rumi, Andrea Russo, Luca Sabia, Andrea Salerno, Sara Salini, Lucia Salvatore, Dehara Samori, Maurizio Sanguinetti, Luca Santarelli, Paolo Santini, Angelo Santoliquido, Francesco Santopaolo, Michele C. Santoro, Francesco Sardeo, Caterina Sarnari, Luisa Saviano, Tommaso Schepis, Francesca Schiavello, Giancarlo Scoppettuolo, Carlo Settanni, Valentina Siciliano, Benedetta Simeoni, Andrea Smargiassi, Domenico Staiti, Leonardo Stella, Eleonora Taddei, Rossella Talerico, Enrica Tamburrini, Pietro Tilli, Enrico Torelli, Matteo Tosato, Luca Tricoli, Marcello Tritto, Mario Tumbarello, Anita M. Tummolo, Federico Valletta, Giulio Ventura, Lucrezia Verardi, Lorenzo Vetrone, Giuseppe Vetrugno, Elena Visconti, Raffaella Zaccaria, Lorenzo Zelano, Lorenzo Zileri Dal Verme, Giuseppe Zuccalà, and International Journal of Clinical Practice, 2021 The COVID‐19 pandemic represents a source of stress and potential burnout for many physicians. This single‐site survey aimed at assessing perceived stress and risk to develop burnout syndrome among physicians operating in COVID wards.
