Human gut microbiota, complex microbial communities, NGS approaches
32
Scopus Publications
723
Scholar Citations
15
Scholar h-index
19
Scholar i10-index
Scopus Publications
Combined Probiotic Lactiplantibacillus plantarum ECGC 13110402 and Plant Sterol Supplement May Improve Lipids and Gut Microbiota in Coeliac Adults: A Randomised, Placebo-Controlled Pilot Human Intervention Study Adele Costabile, Lorretta Olu Fagbemi, Carlo Soldaini, Monica Siniscalchi, Monica Ruotolo, Monica Barone, Marco Fabbrini, Patrizia Brigidi, Silvia Turroni, Sofia Kolida, Yvonne Jeanes, Carolina Ciacci Molecules, 2026 Evidence suggests that a gluten-free diet may increase the risk of metabolic abnormalities associated with cardiovascular disease in adults with Coeliac Disease (CeD). This 9-week, double-blind, placebo-controlled, randomised pilot study investigated the effects of a combined supplement containing probiotic Lactiplantibacillus plantarum ECGC 13110402 and plant sterols and stanols, on cardiometabolic biomarkers and gut microbiota diversity and composition in adults with CeD and hypercholesterolaemia. Blood lipid profiles and vitamin D concentrations were analysed, and gut microbiota was profiled via 16S rRNA amplicon sequencing. In the active group, significant reductions in total cholesterol, LDL-cholesterol, non-HDL cholesterol, and apolipoprotein B were observed at multiple time points during the treatment phase, with changes generally greater in magnitude compared with the placebo group. Vitamin D levels also increased in the active group during supplementation. Microbiota analysis revealed potentially beneficial changes in participants receiving the active formulation, including higher alpha diversity and higher proportions of Bifidobacterium spp., Christensenellaceae R-7 group, and Lachnospiraceae ND3007 group. Overall, this feasibility study provides exploratory findings that a combined Lactiplantibacillus plantarum ECGC 13110402-phytosterol formulation may support lipid management and beneficially modulate gut microbiota in adults with CeD, particularly for those seeking non-pharmacological approaches to improving cardiometabolic health biomarkers.
Associations of Adiposity With Gut Microbiota Composition Among Adults—Results From a Federated Analysis of Individual Participant Data From Eight European Observational Studies Carolina Schwedhelm, Mariona Pinart, Sofia Kirke Forslund-Startceva, Kolade Oluwagbemigun, Andreas Dötsch, et al. Obesity Reviews, 2026 ABSTRACT Gut microbiota may contribute to the adiposity‐associated disease risk, but human studies reported inconsistent associations of adiposity with gut microbiota composition. We examined associations of body mass index (BMI) with alpha diversity and relative microbial abundance at the phylum and genus taxonomic levels (based on 16S rRNA amplicon sequencing or metagenomics) among 7415 adults from eight European observational studies in a joint federated analysis of harmonized data using DataSHIELD. Higher BMI (per 5 kg/m 2 ) was associated with lower alpha diversity ( β : −0.05; 95% CI: −0.07, −0.03) and, on the phylum level, positively associated with Proteobacteria, but neither with Firmicutes nor Bacteroidetes nor their ratio, where high between‐study heterogeneity was observed. On the genus level, BMI was inversely associated with the relative abundance of Faecalibacterium of the Firmicutes phylum ( β : −0.11; 95% CI: −0.14, −0.07) but positively with the odds of detection of Dorea , Streptococcus , and Clostridium (all three Firmicutes) as well as Collinsella (Actinobacteria). This federated analysis of multiple studies found lower alpha diversity, alongside depleted Faecalibacterium , as well as higher odds of detection of Dorea , Streptococcus , Clostridium , and Collinsella with higher adiposity. By combining data from diverse study populations using harmonized data and statistical methods, our analysis partly overcomes sources of heterogeneity that may explain previously observed inconsistencies.
Consumption of only wild foods induces large scale, partially persistent alterations to the gut microbiome Simone Rampelli, Diederik Pomstra, Monica Barone, Marco Fabbrini, Silvia Turroni, Marco Candela, Amanda G. Henry Scientific Reports, 2025 The gut microbiome (GM) is implicated in human health and varies among lifestyles. So-called "traditional" diets have been suggested to promote health-associated taxa. However, most studies focused only on diets including domesticated foods. Historically, humans consumed only wild foods, which might uniquely shape GM composition. We explored the impact of a wild-food-only diet on GM, particularly whether it increases the presence of health-associated and/or "old friend" taxa, and if the alterations to GM are persistent or transient. One participant collected daily fecal samples and recorded daily food consumption over an eight-week period, the middle four weeks of which he consumed only wild foods. Samples were profiled by 16S rRNA sequencing, and oligotyping and network analysis were conducted to assess microbial co-occurrence patterns. A wild-food-only diet considerably alters the composition of the GM, and the magnitude of the changes is larger than that observed in other diet interventions. No new taxa, including "old friends" appeared; instead, the proportions of already-present taxa shifted. Network analysis revealed distinct microbial co-abundance groups restructuring across dietary phases. There is a clear successional shift from the pre-, during- and post-wild-food-only diet. This analysis highlighted structural and functional shifts in microbial interactions, underscoring diet's role in shaping the gut ecosystem.
Microbiome-based prediction of allogeneic hematopoietic stem cell transplantation outcome Oshrit Shtossel, Adi Eshel, Shalev Fried, Mika Geva, Ivetta Danylesko, et al. Genome Medicine, 2025 BACKGROUND: Allogeneic hematopoietic stem cell transplantation (HSCT) is potentially curative for hematologic malignancies but is frequently complicated by relapse and immune-mediated complications, such as graft-versus-host disease (GVHD). Emerging evidence suggests a role for the intestinal and oral microbiome in modulating HSCT outcomes, yet predictive models incorporating microbiome data remain limited. METHODS: We applied the RATIO (suRvival Analysis lefT barrIer lOss) model to longitudinal stool and saliva microbiome data from 204 adult HSCT recipients to predict the timing of seven outcomes: overall survival (OS), non-relapse mortality (NRM), relapse, acute GVHD (grades II-IV and III-IV), chronic GVHD, and oral chronic GVHD. A total of 514 stool and 1291 saliva samples were collected over 70 weeks post-HSCT. Model performance was evaluated using the concordance index (CI) and Spearman correlation coefficient (SCC), with SHAP (SHapley Additive exPlanations) analysis used for model interpretability. RESULTS: Oral and stool microbial dysbiosis peaked within the first 2 weeks post-HSCT, followed by partial recovery. Using the RATIO model, we found that microbiome features from early time points (weeks 1-2) were most predictive of short-term complications such as acute GVHD, while later samples (weeks 36-70) were more informative for long-term outcomes, including overall survival. RATIO outperformed traditional survival models (Cox and Random Survival Forest) across most outcomes (median CI > 0.65), with stool microbiota showing greater predictive power than saliva. SHAP analysis identified specific stool genera, including Collinsella and Eggerthella, associated with shorter time to various complications. External validation using a pediatric GVHD cohort confirmed the model's generalizability and reproducibility. External validation using a pediatric HSCT cohort (n = 90) confirmed the reproducibility and generalizability of these microbiome-based predictions. CONCLUSIONS: Microbiome profiling of stool and saliva samples offers robust, time-sensitive prediction of post-HSCT complications. The RATIO model enables interpretable, time-to-event prediction across multiple outcomes and may inform microbiome-guided interventions to improve transplant success.
Distinct functional and compositional properties in the gut microbiome of children with acute lymphoblastic leukaemia identified by shotgun metagenomics Edoardo Muratore, Gabriele Conti, Marco Fabbrini, Daniele Zama, Nunzia Decembrino, Paola Muggeo, Rosamaria Mura, Katia Perruccio, Davide Leardini, Monica Barone, Marco Zecca, Simone Cesaro, Patrizia Brigidi, Silvia Turroni, Riccardo Masetti Scientific Reports, 2025 Acute lymphoblastic leukaemia (ALL) represents the most common childhood malignancy, and emerging evidence underscores the impact of the gut microbiome (GM) on its pathogenesis. In this study, we used shotgun metagenomics to investigate the GM of 30 ALL patients at diagnosis-19 with B-ALL and 11 with T-ALL-and compared them to 176 healthy controls (HCs). When considered as a single ALL group versus HCs, clear compositional differences emerged: ALL patients exhibited higher relative abundances of Enterococcus faecium, oral commensals such as Rothia dentocariosa, and multiple opportunistic species, whereas HCs were enriched in short-chain fatty acid producers like Anaerostipes hadrus and Intestinibacter bartlettii. Functionally, the ALL GM relied more on protein and amino acid catabolism, while HCs possessed enhanced pathways for carbohydrate and folate metabolism. These findings broadly align with 16S rRNA-based analyses from previous publications, though some discrepancies highlight differences in technique-driven resolution. In contrast, comparing the two major molecular phenotypes-B-ALL and T-ALL-revealed only minimal taxonomic and functional differences, primarily confined to BAs metabolism pathways. Overall, our results indicate that children with ALL at the time of diagnosis already display a dysbiotic signature, bolstering the notion that a disturbance in GM development during childhood may be linked to the multistep pathogenesis model of ALL.
Hematopoietic stem cell transplantation disrupts age-related gut microbiota signatures in pediatric and adult recipients Davide Leardini, Marcello Roberto, Sara Roggiani, Edoardo Muratore, Marco Fabbrini, Gianluca Storci, Enrica Tomassini, Elisa Dan, Angela Schipani, Serena De Matteis, Barbara Sinigaglia, Daria Messelodi, Nicola Salvatore Bertuccio, Arcangelo Prete, Patrizia Brigidi, Francesca Bonifazi, Riccardo Masetti Bone Marrow Transplantation, 2025 Allogeneic hematopoietic stem cell transplantation (allo-HSCT) profoundly reshapes the gut microbiome (GM), yet age-related differences in this process remain incompletely understood. In this study, we analyzed stool samples from a cohort of pediatric and adult patients collected before allo-HSCT and at neutrophil engraftment to assess GM dynamics. We observed a significant reduction in alpha diversity post-HSCT across both age groups, with young patients displaying notably lower biodiversity. While GM composition varies among age ranges before transplantation, these distinctions largely disappeared at neutrophil engraftment, indicating a convergence toward a more uniform "transplant-specific" signature. This shift entailed a loss of health-associated, butyrate-producing taxa and a rise in potentially opportunistic bacteria (e.g., Enterococcaceae, Staphylococcaceae). Low pre-allo-HSCT GM diversity correlated with an increased risk of clinically significant acute graft-versus-host disease, overwhelming the age differences, underscoring the clinical relevance of maintaining a balanced microbiome before transplantation. Overall, our findings highlight the importance of age in shaping the pre-transplant GM and reveal how allo-HSCT-driven factors homogenize microbial communities among age ranges, offering insights for future microbiome-targeted interventions to improve transplant outcomes.
Levofloxacin Prophylaxis in Pediatric and Young Adult Allogeneic Hematopoietic Stem Cell Transplantation Recipients Does not Prevent Infective Complications and Infections-related Deaths Davide Leardini, Giacomo Gambuti, Edoardo Muratore, Francesco Baccelli, Francesca Gottardi, Francesco Venturelli, Tamara Belotti, Arcangelo Prete, Marco Fabbrini, Patrizia Brigidi, Silvia Turroni, Riccardo Masetti Open Forum Infectious Diseases, 2025 Background The prophylactic use of quinolones in the setting of allogeneic hematopoietic stem cell transplantation (allo-HCT) is controversial and solid evidence is missing, particularly in children. Methods In this single-center retrospective study, we compared outcomes in patients receiving (n = 74) or not receiving (n = 70) levofloxacin (LVX) prophylaxis, assessing overall survival, event-free survival, acute graft-versus-host disease (aGvHD) and bloodstream infection incidence, and infection-related mortality. Gut microbiota composition was analyzed in a subgroup using 16S rRNA sequencing of stool samples collected pre-HCT and at engraftment. Results We analyzed 144 allo-HCT in 143 patients performed for any indication. No differences were found in the 2 groups regarding main HCT outcomes, namely, cumulative incidence of aGvHD (37.9% vs 43.5%; P = .733), grade III-IV aGvHD (12.2% vs 8.7%; P = .469), gut aGVHD (12.2% vs 17.5%; P = .451), bloodstream infections (25.6% vs 34.1%; P = .236) and death from bacterial infection (9.5% vs 4.3%; P = 0.179). In patients experiencing bacterial infections, those receiving prophylaxis showed higher incidence of quinolone-resistant strains (P = .001). On a subgroup of 50 patients, we analyzed the gut microbiota composition, showing a lower abundance of Blautia (P = .015), Enterococcus (P = .011), and Actinomyces (P = .07) at neutrophil engraftment in patients receiving LVX prophylaxis. Conclusions LVX prophylaxis in the setting of allo-HCT does not prevent infective complications and increases the prevalence of antibiotic-resistant strains.
Early and late gut microbiota signatures of stroke in high salt-fed stroke-prone spontaneously hypertensive rats Silvia Bencivenni, Sara Roggiani, Augusta Zannoni, Gabriele Conti, Marco Fabbrini, Maria Cotugno, Rosita Stanzione, Donatella Pietrangelo, Margherita Litterio, Maurizio Forte, Carla Letizia Busceti, Francesco Fornai, Massimo Volpe, Silvia Turroni, Patrizia Brigidi, Monica Forni, Speranza Rubattu, Federica D’Amico Scientific Reports, 2024 The high salt-fed stroke-prone spontaneously hypertensive rat (SHRSP) is a suitable tool to study the mechanisms underlying stroke pathogenesis. Salt intake modifies the gut microbiota (GM) in rats and humans and alterations of the GM have previously been associated with increased stroke occurrence. We aimed to characterize the GM profile in SHRSPs fed a high-salt stroke-permissive diet (Japanese diet, JD), compared to the closely related stroke-resistant control (SHRSR), to identify possible changes associated with stroke occurrence. SHRSPs and SHRSRs were fed a regular diet or JD for 4 weeks (short-term, ST) or a maximum of 10 weeks (long-term, LT). Stroke occurred in SHRSPs on JD-LT, preceded by proteinuria and diarrhoea. The GM of JD-fed SHRSPs underwent early and late compositional changes compared to SHRSRs. An overrepresentation of Streptococcaceae and an underrepresentation of Lachnospiraceae were observed in SHRSPs JD-ST, while in SHRSPs JD-LT short-chain fatty acid producers, e.g. Lachnobacterium and Faecalibacterium, decreased and pathobionts such as Coriobacteriaceae and Desulfovibrio increased. Occludin gene expression behaved differently in SHRSPs and SHRSRs. Calprotectin levels were unchanged. In conclusion, the altered GM in JD-fed SHRSPs may be detrimental to gut homeostasis and contribute to stroke occurrence.
The gut microbiota as an early predictor of COVID-19 severity Marco Fabbrini, Federica D’Amico, Bernardina T. F. van der Gun, Monica Barone, Gabriele Conti, Sara Roggiani, Karin I. Wold, María F. Vincenti-Gonzalez, Gerolf C. de Boer, Alida C. M. Veloo, Margriet van der Meer, Elda Righi, Elisa Gentilotti, Anna Górska, Fulvia Mazzaferri, Lorenza Lambertenghi, Massimo Mirandola, Maria Mongardi, Evelina Tacconelli, Silvia Turroni, Patrizia Brigidi, Adriana Tami Msphere, 2024 Several studies reported alterations of the human gut microbiota (GM) during COVID-19. To evaluate the potential role of the GM as an early predictor of COVID-19 at disease onset, we analyzed gut microbial samples of 315 COVID-19 patients that differed in disease severity. We observed significant variations in microbial diversity and composition associated with increasing disease severity, as the reduction of short-chain fatty acid producers such as Faecalibacterium and Ruminococcus , and the growth of pathobionts as Anaerococcus and Campylobacter . Notably, we developed a multi-class machine-learning classifier, specifically a convolutional neural network, which achieved an 81.5% accuracy rate in predicting COVID-19 severity based on GM composition at disease onset. This achievement highlights its potential as a valuable early biomarker during the first week of infection. These findings offer promising insights into the intricate relationship between GM and COVID-19, providing a potential tool for optimizing patient triage and streamlining healthcare during the pandemic. IMPORTANCE Efficient patient triage for COVID-19 is vital to manage healthcare resources effectively. This study underscores the potential of gut microbiota (GM) composition as an early biomarker for COVID-19 severity. By analyzing GM samples from 315 patients, significant correlations between microbial diversity and disease severity were observed. Notably, a convolutional neural network classifier was developed, achieving an 81.5% accuracy in predicting disease severity based on GM composition at disease onset. These findings suggest that GM profiling could enhance early triage processes, offering a novel approach to optimizing patient management during the pandemic.
Gut microbiome dynamics and Enterobacterales infection in liver transplant recipients: A prospective observational study Federica D’Amico, Matteo Rinaldi, Renato Pascale, Marco Fabbrini, Maria Cristina Morelli, Antonio Siniscalchi, Cristiana Laici, Simona Coladonato, Matteo Ravaioli, Matteo Cescon, Simone Ambretti, Pierluigi Viale, Patrizia Brigidi, Silvia Turroni, Maddalena Giannella Jhep Reports, 2024 Background & Aims: The aim of this study was to investigate gut microbiome (GM) dynamics in relation to carbapenem-resistant Enterobacterales (CRE) colonization, CRE infection, and non-CRE infection development within 2 months after liver transplant (LT). Methods: A single-center, prospective study was performed in patients undergoing LT from November 2018 to January 2020. The GM was profiled through 16S rRNA amplicon sequencing of a rectal swab taken on the day of transplantation, and fecal samples were collected weekly until 1 month after LT. A subset of samples was subjected to shotgun metagenomics, including resistome dynamics. The primary endpoint was to explore changes in the GM in the following groups: (1) CRE carriers developing CRE infection (CRE_I); (2) CRE carriers not developing infection (CRE_UI); (3) non-CRE carriers developing microbial infection (INF); and (4) non-CRE carriers not developing infection (NEG). Results: were significantly higher in CRE_I patients than in NEG patients even before LT, serving as an early marker of subsequent CRE infection. CRE_UI patients had a more stable and diverse GM, whose compositional dynamics tended to overlap with those of NEG patients. Conclusions: GM profiling before LT could improve patient stratification and risk prediction and guide early GM-based intervention strategies to reduce infectious complications and improve overall prognosis. Impact and implications: Little is known about the temporal dynamics of gut microbiome (GM) in liver transplant recipients associated with carbapenem-resistant Enterobacterales (CRE) colonization and infection. The GM structure and functionality of patients colonized with CRE and developing infection appeared to be distinct compared with CRE carriers without infection or patients with other microbial infection or no infection and CRE colonization. Higher proportions of antimicrobial-resistant pathogens and poor representation of bacteria and metabolic pathways capable of promoting overall host health were observed in CRE carriers who developed infection, even before liver transplant. Therefore, pretransplant GM profiling could improve patient stratification and risk prediction and guide early GM-based intervention strategies to reduce infectious complications and improve overall prognosis.
The Core Human Microbiome: Does It Exist and How Can We Find It? A Critical Review of the Concept Itai Sharon, Narciso Martín Quijada, Edoardo Pasolli, Marco Fabbrini, Francesco Vitali, Valeria Agamennone, Andreas Dötsch, Evelyne Selberherr, José Horacio Grau, Martin Meixner, Karsten Liere, Danilo Ercolini, Carlotta de Filippo, Giovanna Caderni, Patrizia Brigidi, Silvia Turroni Nutrients, 2022
Nuclear phosphoinositides: Their regulation and roles in nuclear functions R. Fiume, I. Faenza, B. Sheth, A. Poli, M.C. Vidalle, C. Mazzetti, S.H. Abdul, F. Campagnoli, M. Fabbrini, S.T. Kimber, G.A. Mariani, J. Xian, M.V. Marvi, S. Mongiorgi, Z. Shah, N. Divecha International Journal of Molecular Sciences, 2019
RECENT SCHOLAR PUBLICATIONS
Combined Probiotic Lactiplantibacillus plantarum ECGC 13110402 and Plant Sterol Supplement May Improve Lipids and Gut Microbiota in Coeliac Adults: A … A Costabile, LO Fagbemi, C Soldaini, M Siniscalchi, M Ruotolo, M Barone, ... Molecules 31 (10), 1722 , 2026 2026
Associations of Adiposity With Gut Microbiota Composition Among Adults—Results From a Federated Analysis of Individual Participant Data From Eight European Observational Studies C Schwedhelm, M Pinart, SK Forslund‐Startceva, K Oluwagbemigun, ... Obesity Reviews, e70106 , 2026 2026
Distinct functional and compositional properties in the gut microbiome of children with acute lymphoblastic leukaemia identified by shotgun metagenomics E Muratore, G Conti, M Fabbrini, D Zama, N Decembrino, P Muggeo, ... Scientific Reports 15 (1), 43082 , 2025 2025
Hematopoietic stem cell transplantation disrupts age-related gut microbiota signatures in pediatric and adult recipients D Leardini, M Roberto, S Roggiani, E Muratore, M Fabbrini, G Storci, ... Bone Marrow Transplantation 60 (12), 1611-1621 , 2025 2025 Citations: 4
HEMATOPOIETIC STEM CELL TRANSPLANTATION DISRUPTS AGE-RELATED GUT MICROBIOTA SIGNATURES IN PEDIATRIC AND ADULT PATIENTS D Leardini, M Roberto, S Roggiani, E Muratore, M Fabbrini, A Prete, ... BONE MARROW TRANSPLANTATION 60, 816-817 , 2025 2025
PATIENT DIARY AS A TOOL FOR EARLY SYMPTOM DETECTION AND FOSTERING PATIENT ENGAGEMENT IN ONCOHEMATOLOGICAL POPULATION: A SCOPING REVIEW S Gnecchi, B Rizzo, M Fabbrini, A Carmagnola, F Ciceri BONE MARROW TRANSPLANTATION 60, 956-956 , 2025 2025
GUT MICROBIOME ALTERATIONS AND FUNCTIONAL PATHWAYS ASSOCIATED WITH SEVERE AGVHD IN PEDIATRIC ALLO-HSCT RECIPIENTS: THE ROLE OF RUMINOCOCCUS GNAVUS AND LACTOBACILLUS RHAMNOSUS E Muratore, G Conti, D Leardini, M Fabbrini, M Zecca, M Faraci, ... BONE MARROW TRANSPLANTATION 60, 476-477 , 2025 2025
Microbiome-based prediction of allogeneic hematopoietic stem cell transplantation outcome O Shtossel, A Eshel, S Fried, M Geva, I Danylesko, R Yerushalmi, ... Genome Medicine 17 (1), 80 , 2025 2025 Citations: 10
408| INTEGRATIVE PROFILING OF GUT MICROBIOME AND FDG‐PET PARAMETERS AS PREDICTORS OF CAR T‐CELL THERAPY OUTCOMES IN RELAPSED/REFRACTORY DIFFUSE LARGE B‐CELL LYMPHOMAS B Casadei, M Fabbrini, F Bonifazi, C Pellegrini, S Turroni, C Romano, ... Hematological Oncology 43, e408_70094 , 2025 2025
Consumption of only wild foods induces large scale, partially persistent alterations to the gut microbiome S Rampelli, D Pomstra, M Barone, M Fabbrini, S Turroni, M Candela, ... Scientific reports 15 (1), 16593 , 2025 2025 Citations: 4
Levofloxacin prophylaxis in pediatric and young adult allogeneic hematopoietic stem cell transplantation recipients does not prevent infective complications and infections … D Leardini, G Gambuti, E Muratore, F Baccelli, F Gottardi, F Venturelli, ... Open Forum Infectious Diseases 12 (2), ofae707 , 2025 2025 Citations: 7
Associations of body mass index and gut microbiota composition among adults and the role of dietary fiber intake–results from federated analyses of multiple European … C Schwedhelm, M Pinart, S Forslund, K Oluwagbemigun, A Dötsch, ... 2025
Privacy by design of the data journey in AlmaMicrobiome biobank. G Caldoni, F Papa, M Fabbrini, G Conti, E Ferlizza, A Tognoli, M Pallocca, ... Europe Biobank Week 2025 (EBW2025) , 2025 2025
OS-064 Integrating gut microbiota composition and machine learning to predict therapeutic response in hepatocellular carcinoma treated with Atezolizumab and Bevacizumab … F Piscaglia, M Fabbrini, B Stefanini, E Martinelli, F Ciardiello, G Masi, ... Journal of Hepatology 82, s47-s47 , 2025 2025
The gut microbiota as an early predictor of COVID-19 severity M Fabbrini, F D’Amico, BTF Van Der Gun, M Barone, G Conti, S Roggiani, ... Msphere 9 (10), e00181-24 , 2024 2024 Citations: 5
Early and late gut microbiota signatures of stroke in high salt-fed stroke-prone spontaneously hypertensive rats S Bencivenni, S Roggiani, A Zannoni, G Conti, M Fabbrini, M Cotugno, ... Scientific Reports 14 (1), 19575 , 2024 2024 Citations: 6
Gut microbiome dynamics and Enterobacterales infection in liver transplant recipients: A prospective observational study F D’Amico, M Rinaldi, R Pascale, M Fabbrini, MC Morelli, A Siniscalchi, ... JHEP Reports 6 (4), 101039 , 2024 2024 Citations: 7
The predictive role of the human gut microbiota in covid-19: implications for disease severity and post-covid syndrome M Fabbrini alma , 2024 2024
The gut microbiome of Baka forager-horticulturalists from Cameroon is optimized for wild plant foods S Rampelli, S Gallois, F D’Amico, S Turroni, M Fabbrini, D Scicchitano, ... Iscience 27 (3) , 2024 2024 Citations: 5
Aging and Gut Dysbiosis F D’Amico, M Fabbrini, M Barone, P Brigidi, S Turroni Gut Microbiome, Microbial Metabolites and Cardiometabolic Risk, 395-430 , 2024 2024 Citations: 1
MOST CITED SCHOLAR PUBLICATIONS
The core human microbiome: does it exist and how can we find it? A critical review of the concept I Sharon, NM Quijada, E Pasolli, M Fabbrini, F Vitali, V Agamennone, ... Nutrients 14 (14), 2872 , 2022 2022 Citations: 116
Polyphenol and tannin nutraceuticals and their metabolites: How the human gut microbiota influences their properties M Fabbrini, F D’Amico, M Barone, G Conti, M Mengoli, P Brigidi, S Turroni Biomolecules 12 (7), 875 , 2022 2022 Citations: 72
Nuclear phosphoinositides: their regulation and roles in nuclear functions R Fiume, I Faenza, B Sheth, A Poli, MC Vidalle, C Mazzetti, SH Abdul, ... International Journal of Molecular Sciences 20 (12), 2991 , 2019 2019 Citations: 71
Gut microbiota diversity before allogeneic hematopoietic stem cell transplantation as a predictor of mortality in children R Masetti, D Leardini, E Muratore, M Fabbrini, F D’Amico, D Zama, ... Blood 142 (16), 1387-1398 , 2023 2023 Citations: 64
Gut microbiota dynamics during chemotherapy in epithelial ovarian cancer patients are related to therapeutic outcome F D’Amico, AM Perrone, S Rampelli, S Coluccelli, M Barone, G Ravegnini, ... Cancers 13 (16), 3999 , 2021 2021 Citations: 54
Gut microbiota resilience and recovery after anticancer chemotherapy S Roggiani, M Mengoli, G Conti, M Fabbrini, P Brigidi, M Barone, ... Microbiome research reports 2 (3), 16 , 2023 2023 Citations: 37
Connect the dots: sketching out microbiome interactions through networking approaches M Fabbrini, D Scicchitano, M Candela, S Turroni, S Rampelli Microbiome research reports 2 (4), 25 , 2023 2023 Citations: 32
Composition and biodiversity of soil and root-associated microbiome in Vitis vinifera cultivar Lambrusco distinguish the microbial terroir of the Lambrusco DOC … E Nanetti, G Palladino, D Scicchitano, G Trapella, N Cinti, M Fabbrini, ... Frontiers in Microbiology 14, 1108036 , 2023 2023 Citations: 27
Make It Less difficile : Understanding Genetic Evolution and Global Spread of Clostridioides difficile M Mengoli, M Barone, M Fabbrini, F D’Amico, P Brigidi, S Turroni Genes 13 (12), 2200 , 2022 2022 Citations: 26
A personalized diet intervention improves depression symptoms and changes microbiota and metabolite profiles among community-dwelling older adults F Magzal, S Turroni, M Fabbrini, M Barone, A Vitman Schorr, A Ofran, ... Frontiers in nutrition 10, 1234549 , 2023 2023 Citations: 25
Pharmacomicrobiomics in anticancer therapies: why the gut microbiota should be pointed out G Conti, F D’Amico, M Fabbrini, P Brigidi, M Barone, S Turroni Genes 14 (1), 55 , 2022 2022 Citations: 25
Over-feeding the gut microbiome: A scoping review on health implications and therapeutic perspectives M Barone, F D'Amico, M Fabbrini, S Rampelli, P Brigidi, S Turroni World Journal of Gastroenterology 27 (41), 7041 , 2021 2021 Citations: 20
Microbiota-gut-brain axis and ketogenic diet: how close are we to tackling epilepsy? M Mengoli, G Conti, M Fabbrini, M Candela, P Brigidi, S Turroni, ... Microbiome Research Reports 2 (4), 32 , 2023 2023 Citations: 18
Gut microbiota, metabolome, and body composition signatures of response to therapy in patients with advanced melanoma G Vandoni, F D’Amico, M Fabbrini, L Mariani, S Sieri, A Casirati, ... International Journal of Molecular Sciences 24 (14), 11611 , 2023 2023 Citations: 18
Levofloxacin prophylaxis and parenteral nutrition have a detrimental effect on intestinal microbial networks in pediatric patients undergoing HSCT M Fabbrini, F D’Amico, D Leardini, E Muratore, M Barone, T Belotti, ... Communications Biology 6 (1), 36 , 2023 2023 Citations: 18
A comparative absorption (efficacy) study of a sucrosomial biodelivery vehicle-based orodispersible vitamin D3 vs a reference chewable tablet and soft gel capsule vitamin D3 in … A Bano, S Abrar, E Brilli, G Tarantino, AA Bugti, M Fabbrini, G Conti, ... Frontiers in Nutrition 10, 1221685 , 2023 2023 Citations: 14
Microbiome network in the pelagic and benthic offshore systems of the northern Adriatic Sea (Mediterranean Sea) D Scicchitano, M Lo Martire, G Palladino, E Nanetti, M Fabbrini, ... Scientific Reports 12 (1), 16670 , 2022 2022 Citations: 13
G2S: a new deep learning tool for predicting stool microbiome structure from oral microbiome data S Rampelli, M Fabbrini, M Candela, E Biagi, P Brigidi, S Turroni Frontiers in Genetics 12, 644516 , 2021 2021 Citations: 11
Microbiome-based prediction of allogeneic hematopoietic stem cell transplantation outcome O Shtossel, A Eshel, S Fried, M Geva, I Danylesko, R Yerushalmi, ... Genome Medicine 17 (1), 80 , 2025 2025 Citations: 10
Levofloxacin prophylaxis in pediatric and young adult allogeneic hematopoietic stem cell transplantation recipients does not prevent infective complications and infections … D Leardini, G Gambuti, E Muratore, F Baccelli, F Gottardi, F Venturelli, ... Open Forum Infectious Diseases 12 (2), ofae707 , 2025 2025 Citations: 7
