Dr.Sekar Vijayakumar
@mc.wh.sdu.edu.cn
Post Doctoral Research Fellow,Marine College/vijaysekar05@gmail.com
Marine College,Shandong University at Weihai
Sekar currently works Post Doctoral Research Fellow at Marine College, Shandong University, Weihai, P.R.China. does research in Nanopharmacology and Nanotoxicology, Nanobiotechnology, Biopolymers, Nanodrug delivery, Biomaterials, Biofilms, Infectious Diseases, Ecotoxicology, Aquaculture, Immunology and Phytomedicine. He have published more than 85+ research findings in top most peer reviewed index Q1,Q2 journals with a total impact factor of above 290, in addition he have published 5 book chapters in Elsevier and Taylor& Francis publisher and his google scholar profile totally 3220 citations and H index value of 32 and i10 index value of 53. Moreover, he acts as a potential reviewer of the various international Elsevier, RSC, Springer, Frontiers, MDPI and Springer publisher’s journals. He has recently received the “Best Young Scientist Award in Nanobiotechnology”, National conference on SMART SUMMIT-2021 conducted by PEARL Foundation Madurai,Tamilnadu
RESEARCH, TEACHING, or OTHER INTERESTS
Biomaterials, Pharmacology, Toxicology and Pharmaceutics, Biotechnology, Bioengineering
Scopus Publications
Scholar Citations
Scholar h-index
Scholar i10-index
Scopus Publications
Thandapani Gomathi, Susi S, Mohammed Mujahid Alam, Abdullah G. Al-Sehemi, Radha E, Pazhanisamy P, and Sekar Vijayakumar
Elsevier BV
B. Ragini, Sivakumar Kandhasamy, Justin Packia Jacob, and Sekar Vijayakumar
Springer Science and Business Media LLC
Bhuvaneshwari Venkataesan Kumari, Renuka Mani, Balakrishnan Ramajayam Asokan, Karthikeyan Balakrishnan, Arulmani Ramasamy, Rengasamy Parthasarathi, Chitra Kandasamy, Rubalakshmi Govindaraj, Natesan Vijayakumar, and Sekar Vijayakumar
MDPI AG
The present study investigates the green synthesis of silver nanoparticles was carried out using a leaf extract of Anoectochilus elatus (Ae-AgNPs). The synthesised Ae-AgNPs were characterised using different analytical techniques like UV-visible spectroscopy, X-ray diffraction (XRD), Fourier transform infrared (FTIR), and scanning electron microscopy (SEM) with energy-dispersive X-ray analysis (EDX). Additionally, in vitro activities were investigated, and they possess antioxidant, anti-inflammatory, antidiabetic, and antimicrobial properties. The UV-Vis spectra exhibited characteristic absorption peaks at approximately 480 nm. FTIR identified functional groups of the Ae-AgNPs. The crystalline structure of the Ae-AgNPs was verified via XRD analysis. SEM studies revealed that the nanoparticles exhibited a spherical morphology. The fabrication of Ae-AgNPs was established by the EDX spectrum, which exhibited prominent signals of silver atoms. The Ae-AgNPs show potent antioxidant, anti-inflammatory, and antidiabetic activity compared to standard drugs. In addition, Ae-AgNPs demonstrated the most significant zone of Inhibition. This study affirms the superior biological capability of Ae-AgNPs for target drug delivery and their potential for usage in biomedical research and therapeutics.
Esteban F. Durán-Lara, Sekar Vijayakumar, and Roberto Christ Vianna Santos
Elsevier BV
Sonia Kesavan, D Rajesh, Jayashree Shanmugam, S Aruna, Mayakkannan Gopal, and Sekar Vijayakumar
Elsevier BV
R. Sasirekha, Sekar Vijayakumar, P. Pazhanisamy, J. John Joseph, and Thandapani Gomathi
Elsevier BV
Malinie Rajasingam, Subash C.B. Gopinath, Periasamy Anbu, and Sekar Vijayakumar
Elsevier BV
Jose Vinoth Raja Antony Samy, Rajeswari Ranga Anantha Sayanam, Chitra Balasubramanian, Natesan Vijayakumar, Sung-Jin Kim, Sekar Vijayakumar, Mansour K. Gatasheh, Mohammad Shamsul Ola, Omar Ahmed Basudan, Mohamed Saad Daoud,et al.
Elsevier BV
Sekar Vijayakumar, Jingdi Chen, Zaira I. González Sánchez, Kanchanlata Tungare, Mustansir Bhori, Esteban F. Durán-Lara, and Periasamy Anbu
Elsevier BV
Alfredo Pereira, Elizabeth Valdés-Muñoz, Adolfo Marican, Gustavo Cabrera-Barjas, Sekar Vijayakumar, Oscar Valdés, Diana Rafael, Fernanda Andrade, Paulina Abaca, Daniel Bustos,et al.
MDPI AG
In light of the growing bacterial resistance to antibiotics and in the absence of the development of new antimicrobial agents, numerous antimicrobial delivery systems over the past decades have been developed with the aim to provide new alternatives to the antimicrobial treatment of infections. However, there are few studies that focus on the development of a rational design that is accurate based on a set of theoretical-computational methods that permit the prediction and the understanding of hydrogels regarding their interaction with cationic antimicrobial peptides (cAMPs) as potential sustained and localized delivery nanoplatforms of cAMP. To this aim, we employed docking and Molecular Dynamics simulations (MDs) that allowed us to propose a rational selection of hydrogel candidates based on the propensity to form intermolecular interactions with two types of cAMPs (MP-L and NCP-3a). For the design of the hydrogels, specific building blocks were considered, named monomers (MN), co-monomers (CM), and cross-linkers (CL). These building blocks were ranked by considering the interaction with two peptides (MP-L and NCP-3a) as receptors. The better proposed hydrogel candidates were composed of MN3-CM7-CL1 and MN4-CM5-CL1 termed HG1 and HG2, respectively. The results obtained by MDs show that the biggest differences between the hydrogels are in the CM, where HG2 has two carboxylic acids that allow the forming of greater amounts of hydrogen bonds (HBs) and salt bridges (SBs) with both cAMPs. Therefore, using theoretical-computational methods allowed for the obtaining of the best virtual hydrogel candidates according to affinity with the specific cAMP. In conclusion, this study showed that HG2 is the better candidate for future in vitro or in vivo experiments due to its possible capacity as a depot system and its potential sustained and localized delivery system of cAMP.
Jayashree Shanmugam, Gideon Melshi Christiana, Sonia Kesavan, Jeyabaskar Anbumalarmathi, Ravichandran Balaji, Mayakkannan Gopal, Sundararaj Aruna Sharmili, and Sekar Vijayakumar
Springer Science and Business Media LLC
Sekar Vijayakumar, K. Vijayalakshmi, V. Sangeetha, and E. Radha
CRC Press
Felipe Alves de Almeida, Ramanathan Srinivasan, and Sekar Vijayakumar
Frontiers Media SA
Recent advancement in nanoscience and nanotechnology has given us scope for developing biomimetic and biocompatible nanoparticles/nanomaterials using natural products. Nanoparticles/nanomaterials exhibit remarkable physicochemical and biological properties, which are entirely distinct from their bulk materials, making them ideal candidates for biological applications. The plant, microorganisms, and biopolymersbased nanoparticles/nanomaterials are highly advantageous compared to those involving chemical reductants. The biological synthesis method uses eco-friendly solvents and nontoxic chemicals and thereby helps in minimizing the release of hazardous wastes to the environment. In recent years, widespread microbial infections and mosquito-borne parasitic diseases have been a major threat to humans. In addition, dreadful diseases like cancer have become more common and bring massive mortality to human populations. Many of the currently available growth inhibitory agents and chemotherapeutics are too expensive, cause drug resistance, and have numerous side effects. In this scenario, developing novel therapeutic agents that are cost-effective, safe, and without any side effects is of utmost importance. The development of biological nanoparticles/nanomaterials either from plants, microorganisms, or biopolymers is the need of the hour. Most of the newly developed bionanoparticles/bionanomaterials are promising and have significantly contributed to preventing ailments. This Research Topic, “Biosynthesis of bio-inspired nanoparticles/nanomaterials and evaluation of their therapeutic potential in the medical field”, aimed to include the synthesis, physicochemical characterization, in vitro and in vivo evaluation of the antimicrobial, anti-biofilm, anti-quorum sensing, antiviral, anti-infective, and anti-cancer properties of bionanoparticles/bionanomaterials, as well as their application in the treatment and diagnosis of diseases. OPEN ACCESS
Esteban F. Durán-Lara, Adolfo Marican, Diana Rafael, and Sekar Vijayakumar
Bentham Science Publishers Ltd.
Abstract: Bacteria and their enzymatic machinery, also called bacterial cell factories, produce a diverse variety of biopolymers, such as polynucleotides, polypeptides and polysaccharides, with different and fundamental cellular functions. Polysaccharides are the most widely used biopolymers, especially in biotechnology. This type of biopolymer, thanks to its physical and chemical properties, can be used to create a wide range of advanced bio-based materials, hybrid materials and nanocomposites for a variety of exciting biomedical applications. In contrast to synthetic polymers, bacterial polysaccharides have several advantages, such as biocompatibility, biodegradability, low immunogenicity, and non-toxicity, among others. On the other hand, the main advantage of bacterial polysaccharides compared to polymers extracted from other natural sources is that their physicochemical properties, such as purity, porosity, and malleability, among others, can be adapted to a specific application with the use of biotechnological tools and/or chemical modifications. Another great reason for using bacterial polysaccharides is due to the possibility of developing advanced materials from them using bacterial factories that can metabolize raw materials (recycling of industrial and agricultural wastes) that are readily available and in large quantities. Moreover, through this strategy, it is possible to curb environmental pollution. In this article, we project the desire to move towards large-scale production of bacterial polysaccharides taking into account the benefits, weaknesses and prospects in the near future for the development of advanced biological materials for medical and pharmaceutical purposes.
Sekar Vijayakumar, Jingdi Chen, Zaira I. González-Sánchez, Esteban F. Durán-Lara, Mani Divya, Krishnan Shreema, Hushnaara Hadem, R. Mathammal, Murugesan Prasannakumar, and Baskaralingam Vaseeharan
Springer Science and Business Media LLC
Thiyakarajan Sutharappa Kaliyamoorthy, Vijayakumar Subramaniyan, Sangeetha Renganathan, Vidhya Elavarasan, Jagatheesvaran Ravi, Praseetha Prabhakaran Kala, Prathipkumar Subramaniyan, and Sekar Vijayakumar
MDPI AG
The bio-synthesis of zinc oxide nanoparticles (ZnO NPs) using aqueous leaf extract of Pisonia grandis is discussed in this work as an effective ecologically beneficial and straightforward method. This strategy intends to increase ZnO nanoparticle usage in the biomedical and environmental sectors, while reducing the particle of hazardous chemicals in nanoparticle synthesis. In the current study, bio-augmented zinc oxide nanomaterials (ZnO-NPs) were fabricated from Pisonia grandis aqueous leaf extracts. Different methods were used to analyze the ZnO-nanoparticles including X-ray diffraction (XRD), Fourier Transforms Infrared (FT-IR), Ultraviolet (UV) spectroscopy, and Field Emission Scanning Electron Microscopy (FE-SEM) with EDX. The synthesized nanoparticles as spheres were verified by FE-SEM analysis; XRD measurements showed that the particle flakes had an average size of 30.32 nm and were very pure. FT-IR analysis was used to validate the functional moieties in charge of capping and stabilizing ZnO nanoparticles. The antimicrobial, cytotoxic, and photodegradation properties of synthesized nanoparticles were assessed using well diffusion, MTT, and UV visible irradiation techniques. The bio-fabricated nanoparticles were proven to be outstanding cytotoxic and antimicrobial nanomaterials. As a result of the employment of biosynthesized ZnO nanoparticles as photocatalytic agents, 89.2% of the methylene blue dye was degraded in 140 min. ZnO nanoparticles produced from P. grandis can serve as promising substrates in biomedicine and applications of environmental relevance due to their eco-friendliness, nontoxic behavior, and cytocompatibility.
Nilavukkarasi Mohandoss, Sangeetha Renganathan, Vijayakumar Subramaniyan, Punitha Nagarajan, Vidhya Elavarasan, Prathipkumar Subramaniyan, and Sekar Vijayakumar
MDPI AG
Capparis zeylanica leaf extract was employed in this work to create iron oxide nanoparticles (α-Fe2O3) using anhydrous ferric chloride. The UV spectrum, XRD, FT-IR, and FE-SEM with EDX methods were used to characterize the fabricated nanoparticles. The iron oxide nanoparticles obtained were spherical in form, with an average crystallite size of 28.17 nm determined by XRD. The agar well diffusion method was used to assess the antimicrobial activity of the α-Fe2O3 nanoparticles created in this study against pathogenic organisms, Gram-negative bacteria (Escherichia coli and Pseudomonas aeroginosa), Gram-positive bacteria (Staphylococcus aureus and Streptococcus pyogenes), and fungi (Candida albicans and Aspergillus niger). Among the pathogens tested, S. pyogenes had the highest zones of inhibition (25 ± 1.26 mm), followed by S. aureus (23 ± 0.8 mm), E. coli (23 ± 2.46 mm), P. aeroginosa (22 ± 1.86 mm), C. albicans (19 ± 2.34 mm) and A. niger (17 ± 3.2 mm). The substance was further tested for anticancer activity against A549 (lung cancer) cells using the MTT assay. The cytotoxic reaction was found to be concentration-dependent. The present study, therefore, came to the conclusion that the bio-effectiveness of the manufactured α-Fe2O3 nanoparticles may result in applications in biomedical domains.
Tamil Elakkiya Mathizhagan, Vijayakumar Subramaniyan, Sangeetha Renganathan, Vidhya Elavarasan, Prathipkumar Subramaniyan, and Sekar Vijayakumar
MDPI AG
Recent advances in nanotechnology have placed a major emphasis on environmentally friendly processes that encourage sustainable growth by using moderate reaction conditions and non-toxic precursors. In the present study, a simple, inventive, and affordable green technique was applied to generate bio-augmented ZnO nanoparticles using an aqueous extract of tea residue as a reducing and stabilizing component. Numerous methods, including UV-Vis, XRD, FT-IR, FE-SEM with EDAX and TEM were used to analyze ZnO nanoparticles that were generated. The antimicrobial capabilities of biomediated ZnO nanoparticles against pathogenic organisms were examined using an agar well method. 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT assay) and flow cytometry analysis was utilized to explore cytotoxic effects and apoptosis, and methylene blue dye was used to examine photocatalytic activity. The ZnO nanoparticles demonstrated considerable anticancer activity in human lung cancer cells (A549) as well as highly effective antibacterial activity against several different microbial pathogens. Furthermore, the greatest degradation percentage of methylene blue obtained was found to be 86% after 140 min. Therefore, it is concluded that the chosen nanoparticle combination enhanced antimicrobial, anticancer and photocatalytic activities. The combination may represent a useful tool for removing dye pollution from wastewater and, ideally, be used in the pharmaceutical sector to combat lung cancer.
Fernanda Andrade, María Mercé Roca-Melendres, Monserrat Llaguno, Diana Hide, Imma Raurell, María Martell, Sekar Vijayakumar, Mireia Oliva, Simó Schwartz, Esteban F. Durán-Lara,et al.
Elsevier BV
Sekar Vijayakumar, Jingdi Chen, Viswanathan Kalaiselvi, Kanchanlata Tungare, Mustansir Bhori, Zaira I. González-Sánchez, and Esteban F. Durán-Lara
Elsevier BV
Narayanan Gopi, Arokiadhas Iswarya, Sekar Vijayakumar, Sangily Jayanthi, Siti Azizah Mohd Nor, Palaniyandi Velusamy, and Baskaralingam Vaseeharan
Elsevier BV
Sekar Vijayakumar, Jingdi Chen, Mani Divya, Esteban F. Durán-Lara, Murugesan Prasannakumar, and Baskaralingam Vaseeharan
Springer Science and Business Media LLC
Sindhu Sivalingam, Sivakumar Kandhasamy, Sivaraj Chandrasekaran, Karthikeyan Vijayan, Justin P Jacob, Arumugam Perumal, and Sekar Vijayakumar
Elsevier BV
Mohanapriya Chelladurai, Gopinath Margavelu, Sekar Vijayakumar, Zaira Isabel González-Sánchez, Karthikeyan Vijayan, and Renganathan Sahadevan
Elsevier BV
Mani Divya, Sekar Vijayakumar, and Baskaralingam Vaseeharan
Springer Singapore