ADEKUNLE BASHIRU OKESINA

@unilorin.edu.ng

Professor Chemical Pathology and Immunology /Basic Clinical Sciences
University of Ilorin

ADEKUNLE BASHIRU OKESINA


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RESEARCH, TEACHING, or OTHER INTERESTS

Clinical Biochemistry, Endocrinology, General Biochemistry, Genetics and Molecular Biology
29

Scopus Publications

Scopus Publications

  • The status of newborn screening in Africa:Situation analysis, future plans and call to action
    Tumelo Satekge, Adekunle Okesina, John Anetor, Rajiv Erasmus
    African Journal of Laboratory Medicine, 2025
    No abstract available.
  • Relationship between glycaemic control with microalbuminuria and trace metals in patients with type 2 diabetes mellitus: A cross-sectional study from University of Ilorin teaching hospital, Nigeria
    Journal of Krishna Institute of Medical Sciences University, 2025
  • Lipid profile in subfertile clients with premature ovarian failure: University of Ilorin teaching hospital experience
    Journal of Krishna Institute of Medical Sciences University, 2018
  • Assessment of seminal biomarker of lipid peroxidation among male partners of infertile couples at the university of ilorin teaching hospital, Nigeria
    OlatunbosunWaliu Oladosu, SikiruAbayomi Biliaminu, IsholaMusbau Abdulazeez, VictorUgochukwu Nwadike, Jameelu-deenOmokunmi Yusuff, et al.
    Nigerian Postgraduate Medical Journal, 2018
    Background: Seminal fluid analysis (SFA) is the most important investigation of infertile males. It is however limited in revealing the aetiologies of the various spermatozoa abnormalities observed on microscopy. Increasing prevalence of male infertility and the challenges of diagnosis require biochemical investigations, such as assay of seminal malondialdehyde (MDA), a marker of sperm peroxidation and to support SFA in investigation of infertile males. Aims: The aim of this study was to determine the seminal level of biomarker of lipid peroxidation by measuring seminal MDA levels among infertile males in Ilorin. Settings and Design: This was a descriptive cross-sectional study. Subjects and Methods: One hundred and thirty infertile males served as patients and 50 fertile males as controls. Seminal MDA was assayed using ELISA method. Statistical Analysis Used: Statistical Package for the Social Sciences (SPSS) version 20.0 (SPSS Inc., Chicago, IL, USA) was used. Normally distributed data were expressed as mean ± standard deviation. Results: The mean age of the patients who were mainly civil servants was 38.6 ± 6.6 years compared to 37.0 ± 5.8 years among controls. Seminal MDA was significantly higher among infertile males in this study (P < 0.05) indicating higher degree of lipid peroxidation in their semen. Seminal MDA concentrations were found to be significantly higher among infertile males with a history of alcohol consumption (P < 0.05), cigarette smoking (P < 0.001) and sexually transmitted infections (P < 0.001) when compared to control with similar history. Conclusions: There is significant lipid peroxidation of spermatozoa among infertile males with lifestyle playing a significant role. Evaluation of infertile males should include assessment of seminal MDA. Prophylactic administration of antioxidants to this group of patients may be beneficial.
  • The role of laboratory medicine in addressing migrant health problems
    Electronic Journal of the International Federation of Clinical Chemistry and Laboratory Medicine, 2018
  • Trimethyltin-induced cerebellar damage on adult male Wistar rats
    M. S Ajao, A. Okesina, M. C Nwadiugwu, and
    Bionatura, 2018
    Ajao M. S.1, Okesina A.1, Nwadiugwu M. C.1*. DOI. 10.21931/RB/2018.03.04.6 Abstract: This research work was done to investigate the acute toxicological effect of trimethyltin chloride on the cerebellum of Wistar rat. Ten adult male Wistar rats were used for the study. The animals were grouped into two: Group A and B, with five adult male Wistar rats in each group. Group A serves as the trimethyltin (TMT) group, while group B serves as the normal saline (NS) group. 3mg/kg of trimethyltin chloride was administered to animals in the TMT group, while 1.0mls of normal saline was administered to the animals in the NS group via intraperitoneal route for 3 hours respectively. The animals were sacrificed at the Histology Laboratory, University of Ilorin, using 25mg/kg of ketamine administered intramuscularly to anesthetize the animals; followed by perfusion fixation through the heart. The brains were harvested, and the tissues were processed and stained using H & E, and crystal violet stains. The cerebellar cortex and nissl substances of the cerebellum were analyzed and showed a mild distortion in the layers of the cerebellar cortex. Biochemical analysis was undertaken to investigate the disruption of the oxidative status in the animal tissue, using Super Oxide Dismutase (SOD). Oxidative stress was found to increase significantly (p < 0.05) in the TMT groups compared with the NS group, because the SOD activity decreased more in the brain homogenates of the TMT group. The result demonstrated that trimethyltin exerts its toxic effect by promoting oxidative stress in the brain and this may affect normal brain functioning and growth.
  • Changes in peak expiratory flow rate, blood pressure and pulse rate following ingestion of increased coffee concentrations in healthy male adults
    Journal of Medicine and Biomedical Research, 2012
  • Biochemical changes in primary open angle glaucoma patients in a nigerian teaching hospital
    European Journal of Scientific Research, 2011
  • Prevalence of hypertension and associated variables in PATD workers in Ilorin, Nigeria
    Nigerian Journal of Clinical Practice, 2008
  • Effect of food processing on glycemic response to white yam (Dioscorea rotunda) meals
    Diabetologia Croatica, 2008
  • Clinical laboratory in the biochemical evaluation of hypertension in Nigeria.
    African Journal of Medicine and Medical Sciences, 2007
  • Pattern of some risk factors for cardiovascular disease in untreated Nigerian hypertensive patients
    West African Journal of Medicine, 2006
  • Role of hepatic enzymes in the biochemical assessment of the severity of sickle cell anemia.
    Tropical Gastroenterology Official Journal of the Digestive Diseases Foundation, 2006
  • High Risk Coronary Heart Disease, Lipid Fractions and Transferrin Saturation among Hypertensive Nigerians
    Nigerian Postgraduate Medical Journal, 2005
  • Awareness of atherosclerosis risk factors in Nigeria
    E K Oghagbon, A B Okesina, S A Adebisi
    Journal of the Royal Society for the Promotion of Health, 2004
  • Importance of family history in type 2 black South African diabetic patients
    R T Erasmus, E Blanco Blanco, A B Okesina, J Mesa Arana, Z Gqweta, et al.
    Postgraduate Medical Journal, 2001
  • Prevalence of diabetes mellitus and impaired glucose tolerance in factory workers from Transkei, South Africa
    South African Medical Journal, 2001
  • Blood sugar control among fasting Muslims with type 2 diabetes mellitus in Ilorin.
    Nigerian Journal of Medicine Journal of the National Association of Resident Doctors of Nigeria, 2001
  • Serum electrolyte, urea and creatinine in clinically stable Nigerian newborn.
    West African Journal of Medicine, 2001
  • Prevalence of diabetes mellitus and impaired glucose tolerance in factory workers from Transkei, South Africa
    Journal of Endocrinology Metabolism and Diabetes of South Africa, 2001
  • Effect of drug-induced hyperuricaemia on renal function in Nigerians with pulmonary tuberculosis.
    African Journal of Medicine and Medical Sciences, 2000
  • Prevalence of some risk factors of coronary heart disease in a rural Nigerian population
    East African Medical Journal, 1999
  • Assessment of glycaemic control in stable type 2 black South African diabetics attending a peri-urban clinic
    R T Erasmus, E Blanco Blanco, A B Okesina, Z Gqweta, T Matsha
    Postgraduate Medical Journal, 1999
  • Effect of gestational age on levels of serum alkaline phosphatase isoenzymes in healthy pregnant women
    A.B. Okesina, D. Donaldson, P.T. Lascelles, P. Morris
    International Journal of Gynecology and Obstetrics, 1995
  • Serum gamma glutamyl transferase activities in epileptic patients receiving carbamazepine monotherapy
    A B Okesina, D Donaldson, P T Lascelles
    Annals of Clinical Biochemistry, 1991
  • Isoenzymes of alkaline phosphatase in epileptic patients receiving carbamazepine monotherapy
    A B Okesina, D Donaldson, P T Lascelles
    Journal of Clinical Pathology, 1991
  • Surveillance of humoral immunity to measles virus in Ilorin, Nigeria and environ.
    Central African Journal of Medicine, 1991
  • Plasma urate in diabetes: relationship to glycaemia, glucose disposal, microvascular complications and the variations following oral glucose
    A.O. Olukoga, R.T. Erasmus, K.S. Akinlade, A.B. Okesina, A.A. Alanamu, et al.
    Diabetes Research and Clinical Practice, 1991
  • Prevalence of diabetes mellitus in a nigerian population
    R.T. Erasmus, T. Fakeye, O. Olukoga, A.B. Okesina, E. Ebomoyi, et al.
    Transactions of the Royal Society of Tropical Medicine and Hygiene, 1989