Christophe Sola

@universite-paris-saclay.fr

Life Sciences Department/Faculty of Sciences/Universite-Paris-Saclay

Christophe Sola holds since September 2007 a Full Professorship position in Microbiology at University of Paris-Saclay (UPSay) where he was the Principal Investigator of his research team IGEPE between 2007 and 2019. He is now a senior scientist in an INSERM-University-Paris -Cité Joint Research Unit, named IAME, that stands for “Infection, Antimicrobials, Modeling and Evolution”, working in a lab associated to the French National Research Center Laboratory for Mycobacetriology. His research work focus on Mycobacterium tuberculosis genetic diversity and especially on CRISPR polymorphisms. He was at the origin of the International Spoligotyping Databases created and maintained at the Institut Pasteur, databases that were instrumental in helping to decipher the population structure of the Mycobacterium tuberculosis complex before the Whole-Genome-Sequence era. He is now working in Big Dataset management systems, by developing and analyzing data for public health and academic research

EDUCATION

PharmD PhD

RESEARCH, TEACHING, or OTHER INTERESTS

Microbiology, Applied Microbiology and Biotechnology, Infectious Diseases, Ecology, Evolution, Behavior and Systematics
186

Scopus Publications

14575

Scholar Citations

56

Scholar h-index

153

Scholar i10-index

Scopus Publications

RECENT SCHOLAR PUBLICATIONS

  • Migrations and Tuberculosis: A comparative study of Mycobacterium tuberculosis genomic population structure in Brazil and Mozambique to historical triangular slave trade …
    T Morel-Journel, C Guyeux, C Sola
    Tuberculosis, 102734 , 2026
    2026
  • Genomic characterization and epidemiology of Mycobacterium tuberculosis lineage 2 isolates from Kazakhstan
    D Auganova, S Atavliyeva, N Gharbi, E Zholdybayeva, Y Skiba, ...
    Scientific Reports 15 (1), 37715 , 2025
    2025
    Citations: 2
  • Building a Large Dataset of Genome Mutations Associated with Antibiotic Resistance in Mycobacterium tuberculosis
    J Al Akl, C Abou Jaoude, Z Al Chami, C Guyeux, D Laiymani, C Sola
    2025 IEEE/ACS 22nd International Conference on Computer Systems and … , 2025
    2025
  • An insight into the characterization of L2 Beijing multi-drug resistant tuberculosis: Description of resistance-associated-variants and discovery of Modern 7 L2 sublineage
    MA Soutou, C Allam, M Abifadel, J Najjar, C Guyeux, E Cambau, C Sola
    Infection, Genetics and Evolution, 105797 , 2025
    2025
    Citations: 1
  • In-depth analysis of predominant Mycobacterium tuberculosis L. 2.2. M3 strain from Panama, using TB-Annotator
    JE Ku, F Acosta, E Shitikov, P Patel, D Sambrano, C Guyeux, I Mokrousov, ...
    45th Annual Congress of the European Society for Mycobacteriology , 2025
    2025
  • Developing a tuberculosis q&a database using q&a-et: Question and answer evaluator toolkit
    J Al Akl, C Abou Jaoude, Z Chami, C Guyeux, D Laiymani, C Sola
    2025 5th IEEE Middle East and North Africa Communications Conference … , 2025
    2025
  • Advanced Machine Learning for Predicting Drug Resistance in Clinical Isolates of Mycobacterium Tuberculosis Complex
    N Sirri, C Guyeux, C Sola
    2024 World Conference on Complex Systems (WCCS), 1-8 , 2024
    2024
  • Leveraging LLM-Powered Systems to Accelerate Mycobacterium Tuberculosis Research Step One: From Documents to the Vectorstore
    C Guyeux, D Laiymani, C Sola
    International Conference on Machine Learning, Optimization, and Data Science … , 2024
    2024
    Citations: 1
  • The hidden diversity of mycobacterium tuberculosis complex in africa: the new l10 and the possible diversification histories of the complex
    C Guyeux, G Senelle, A Le Meur, C Sola, G Refrégier
    Annual Congress of the European Society of Mycobacteriology , 2024
    2024
    Citations: 1
  • Study and implementation of a new machine learning algorithm to predict drug resistance in Mycobacterium tuberculosis complex clinical isolates
    N SIRRI, C Guyeux, C Sola
    2024
    Citations: 1
  • Newly identified Mycobacterium africanum lineage 10, central Africa
    C Guyeux, G Senelle, A Le Meur, P Supply, C Gaudin, JE Phelan, ...
    Emerging infectious diseases 30 (3), 560 , 2024
    2024
    Citations: 49
  • Evolution, Phylogenetics, and Phylogeography of Mycobacterium tuberculosis complex
    C Sola, I Mokrousov, MR Sahal, K La, G Senelle, C Guyeux, G Refrégier, ...
    Genetics and Evolution of Infectious Diseases, 683-772 , 2024
    2024
    Citations: 8
  • The paradoxes of Mycobacterium tuberculosis molecular evolution and consequences for the inference of tuberculosis emergence date
    R Zein-Eddine, F Hak, A Le Meur, C Genestet, O Dumitrescu, C Guyeux, ...
    Tuberculosis 143, 102378 , 2023
    2023
    Citations: 2
  • Towards a better understanding of the long-lasting evolutionary history of Mycobacterium tuberculosis
    G Senelle, C Guyeux, G Refrégier, C Sola
    Tuberculosis 143, 102374 , 2023
    2023
    Citations: 3
  • Towards the reconstruction of a global TB history using a new pipeline “TB-Annotator
    G Senelle, MR Sahal, K La, T Billard-Pomares, J Marin, F Mougari, ...
    Tuberculosis 143, 102376 , 2023
    2023
    Citations: 6
  • A de novo diploid genome assembly allows dissecting the transcriptomic differences underlying the clonal phenotypic diversity in cultivar'Malbec'
    L Calderón, P Carbonell-Bejerano, C Muñoz, L Bree, C Sola, D Bergamin, ...
    LVIII Annual Meeting of the Argentine Society for Biochemistry and Molecular … , 2023
    2023
  • Mycobacterium tuberculosis complex drug-resistance, phylogenetics, and evolution in Nigeria: Comparison with Ghana and Cameroon
    MR Sahal, G Senelle, K La, TW Panda, DW Taura, C Guyeux, E Cambau, ...
    PLOS Neglected Tropical Diseases 17 (10), e0011619 , 2023
    2023
    Citations: 6
  • Comparison of in silico predicted Mycobacterium tuberculosis spoligotypes and lineages from whole genome sequencing data
    G Napier, D Couvin, G Refrégier, C Guyeux, CJ Meehan, C Sola, ...
    Scientific reports 13 (1), 11368 , 2023
    2023
    Citations: 14
  • TB-annotator: a scalable web application that allows in-depth analysis of very large sets of publicly available Mycobacterium tuberculosis complex genomes
    G Senelle, C Guyeux, G Refrégier, C Sola
    bioRxiv, 2023.06. 12.526393 , 2023
    2023
    Citations: 4
  • Paleopathology and evolution of tuberculosis editorial
    MA Coqueugniot
    Tuberculosis 143, 102428 , 2023
    2023

MOST CITED SCHOLAR PUBLICATIONS

  • Proposal for Standardization of Optimized Mycobacterial Interspersed Repetitive Unit-Variable-Number Tandem Repeat Typing of Mycobacterium tuberculosis
    P Supply, C Allix, S Lesjean, M Cardoso-Oelemann, S Rüsch-Gerdes, ...
    Journal of clinical microbiology 44 (12), 4498-4510 , 2006
    2006
    Citations: 1850
  • Mycobacterium tuberculosis complex genetic diversity: mining the fourth international spoligotyping database (SpolDB4) for classification, population genetics and …
    K Brudey, JR Driscoll, L Rigouts, WM Prodinger, A Gori, SA Al-Hajoj, ...
    BMC microbiology 6 (1), 23 , 2006
    2006
    Citations: 1422
  • SITVITWEB–a publicly available international multimarker database for studying Mycobacterium tuberculosis genetic diversity and molecular epidemiology
    C Demay, B Liens, T Burguière, V Hill, D Couvin, J Millet, I Mokrousov, ...
    Infection, genetics and evolution 12 (4), 755-766 , 2012
    2012
    Citations: 618
  • Global Phylogeny of Mycobacterium tuberculosis Based on Single Nucleotide Polymorphism (SNP) Analysis: Insights into Tuberculosis Evolution, Phylogenetic …
    I Filliol, AS Motiwala, M Cavatore, W Qi, MH Hazbón, ...
    Journal of bacteriology 188 (2), 759-772 , 2006
    2006
    Citations: 583
  • Characterization of Mycobacterium tuberculosis Complex DNAs from Egyptian Mummies by Spoligotyping
    AR Zink, C Sola, U Reischl, W Grabner, N Rastogi, H Wolf, AG Nerlich
    Journal of clinical microbiology 41 (1), 359-367 , 2003
    2003
    Citations: 516
  • Genome-wide analysis of multi- and extensively drug-resistant Mycobacterium tuberculosis
    F Coll, J Phelan, GA Hill-Cawthorne, MB Nair, K Mallard, S Ali, ...
    Nature genetics 50 (2), 307-316 , 2018
    2018
    Citations: 423
  • The mycobacteria: an introduction to nomenclature and pathogenesis
    N Rastogi, E Legrand, C Sola
    Revue Scientifique Et Technique-Office International Des Epizooties 20 (1 … , 2001
    2001
    Citations: 422
  • Genotyping of the Mycobacterium tuberculosis complex using MIRUs: association with VNTR and spoligotyping for molecular epidemiology and evolutionary genetics
    C Sola, I Filliol, E Legrand, S Lesjean, C Locht, P Supply, N Rastogi
    Infection, genetics and evolution 3 (2), 125-133 , 2003
    2003
    Citations: 380
  • CRISPR typing and subtyping for improved laboratory surveillance of Salmonella infections
    L Fabre, J Zhang, G Guigon, S Le Hello, V Guibert, M Accou-Demartin, ...
    PloS one 7 (5), e36995 , 2012
    2012
    Citations: 310
  • Global distribution of Mycobacterium tuberculosis spoligotypes
    I Filliol, JR Driscoll, D Van Soolingen, BN Kreiswirth, K Kremer, ...
    Emerging infectious diseases 8 (11), 1347 , 2002
    2002
    Citations: 309
  • Spacer oligonucleotide typing of bacteria of the Mycobacterium tuberculosis complex: recommendations for standardised nomenclature
    JW Dale, D Brittain, AA Cataldi, D Cousins, JT Crawford, J Driscoll, ...
    International Journal of Tuberculosis and Lung Disease 5 (3), 216-219 , 2001
    2001
    Citations: 271
  • Genetic Biodiversity of Mycobacterium tuberculosis Complex Strains from Patients with Pulmonary Tuberculosis in Cameroon
    SN Niobe-Eyangoh, C Kuaban, P Sorlin, P Cunin, J Thonnon, C Sola, ...
    Journal of clinical microbiology 41 (6), 2547-2553 , 2003
    2003
    Citations: 236
  • Spoligotype database of Mycobacterium tuberculosis: biogeographic distribution of shared types and epidemiologic and phylogenetic perspectives
    C Sola, I Filliol, MC Gutierrez, I Mokrousov, V Vincent, N Rastogi
    Emerging infectious diseases 7 (3), 390 , 2001
    2001
    Citations: 235
  • Evolution and diversity of clonal bacteria: the paradigm of Mycobacterium tuberculosis
    T Dos Vultos, O Mestre, J Rauzier, M Golec, N Rastogi, V Rasolofo, ...
    PloS one 3 (2), e1538 , 2008
    2008
    Citations: 191
  • Mycobacterium tuberculosis Phylogeny Reconstruction Based on Combined Numerical Analysis with IS 1081, IS 6110, VNTR, and DR-Based Spoligotyping …
    C Sola, I Filliol, E Legrand, I Mokrousov, N Rastogi
    Journal of molecular evolution 53 (6), 680-689 , 2001
    2001
    Citations: 179
  • Mycobacterium tuberculosis complex CRISPR genotyping: improving efficiency, throughput and discriminative power of ‘spoligotyping’ with new spacers and a …
    J Zhang, E Abadia, G Refregier, S Tafaj, ML Boschiroli, B Guillard, ...
    Journal of medical microbiology 59 (3), 285-294 , 2010
    2010
    Citations: 162
  • Spoligotype Signatures in the Mycobacterium tuberculosis Complex
    EM Streicher, TC Victor, G Van Der Spuy, C Sola, N Rastogi, ...
    Journal of clinical microbiology 45 (1), 237-240 , 2007
    2007
    Citations: 159
  • E-DNA Sensor of Mycobacterium tuberculosis Based on Electrochemical Assembly of Nanomaterials (MWCNTs/PPy/PAMAM)
    A Miodek, N Mejri, M Gomgnimbou, C Sola, H Korri-Youssoufi
    Analytical chemistry 87 (18), 9257-9264 , 2015
    2015
    Citations: 142
  • A data-mining approach to spacer oligonucleotide typing of Mycobacterium tuberculosis
    M Sebban, I Mokrousov, N Rastogi, C Sola
    Bioinformatics 18 (2), 235-243 , 2002
    2002
    Citations: 134
  • Methods used in the molecular epidemiology of tuberculosis
    P Moström, M Gordon, C Sola, M Ridell, N Rastogi
    Clinical microbiology and infection 8 (11), 694-704 , 2002
    2002
    Citations: 128