Saheed Olanrewaju Afolabi

Scopus Publications

Sex-Specific Sub-Acute Toxicity and Immunomodulatory Profile of a Nigerian Polyherbal Supplement (Napherbs) In Albino Wistar Rats
Nigerian Journal of Physiological Sciences Official Publication of the Physiological Society of Nigeria, 2025
Comparative effects of alternate tobacco products and traditional tobacco smoking on various organ/systems: A guide to regulators and health policy makers
Saheed Olanrewaju Afolabi, Solomon Olagoke Olaoye, Amase Nyamgee, Anoka Ayembe Njan
Toxicology Reports, 2025
Apoptotic Potential of Iloneoside from Gongronema latifolium Benth against Prostate Cancer Cells Using In Vitro and In Silico Approach
Gideon A. Gyebi, Saheed O. Afolabi, Oludare M. Ogunyemi, Ibrahim M. Ibrahim, Olufunke E. Olorundare, et al.
Cell Biochemistry and Biophysics, 2025
Prostate cancer is a major cause of cancer-related mortality in men worldwide. The anti-proliferative activity of Gongronema latifolium leaf extracts on some cancer cells has been reported. Herein, we investigated the growth inhibitory effect of the Gongronema latilolium leaf methanol extract and isolated pregnane (iloneoside) against prostate cancer cell lines using the MTT cell proliferation assay, apoptosis quantification, cell cycle analysis using flow cytometry and computational analysis molecular docking, molecular dynamics simulation (MDs), binding free energy computation and cluster analysis. In addition, UPLC-ESI-TOFMS chemical fingerprinting of previously isolated compounds was performed. The extract inhibited the growth of the cell lines with an IC50 of 49.3 µg/ml and 28.4 µg/ml for 24 h and 48 h, respectively, for PC3; and 43.7 µg/ml and 22.3 µg/ml for 24 h and 48 h, respectively, for DU145. Iloneoside demonstrated low inhibitory activities against PC3 and DU145 (IC50 > 80 μM). Apoptotic quantification and cell cycle analysis further showed that iloneoside induced apoptosis in a few cells at a dose of 200 uM. The ensemble-based molecular docking of the iloneoside to BCL-XL and BCL-2 proteins, and docking to MCL-1, BCL-A1 and BFL-1 proteins, respectively, presented binding energies of −7.22 ± 0.5, −8.12 ± 0.55, −7.1, −7.2 and −6.3 kcal/mol, while the MM/PBSA binding free energy was −25.72 ± 7.22 and −27.76 ± 11.32 kcal/mol for BCL-XL and BCL-2 proteins. Furthermore, iloneoside was stable during the 100 ns MDs analysis, while the clustering of the MDs trajectories showed that the interactions were strongly preserved. Iloneoside, in part, or in synergy with other constituents, may be responsible for the antiproliferative activities of the leaf, subject to further investigation.
Cholinergic Inhibition and Antioxidant Potential of Gongronema latifolium Benth Leaf in Neurodegeneration: Experimental and In Silico Study
Gideon A. Gyebi, Joseph C. Ejoh, Oludare M. Ogunyemi, Saheed O. Afolabi, Ibrahim M. Ibrahim, et al.
Cell Biochemistry and Biophysics, 2025
Mechanisms of stretch-induced electro-anatomical remodeling and atrial arrhythmogenesis
Roman Y. Medvedev, Saheed O. Afolabi, Daniel G.P. Turner, Alexey V. Glukhov
Journal of Molecular and Cellular Cardiology, 2024
Identification of potential inhibitors of cholinergic and β-secretase enzymes from phytochemicals derived from Gongronema latifolium Benth leaf: an integrated computational analysis
Gideon Ampoma Gyebi, Oludare M. Ogunyemi, Ibrahim M. Ibrahim, Olalekan B. Ogunro, Saheed O. Afolabi, et al.
Molecular Diversity, 2024
Oxidized dietary lipids induce vascular inflammation and atherogenesis in post-menopausal rats: estradiol and selected antihyperlipidemic drugs restore vascular health in vivo
Joy Temiloluwa Folahan, Olufunke Esan Olorundare, Abayomi Mayowa Ajayi, Adeoye Oyetunji Oyewopo, Sunday Sokunle Soyemi, et al.
Lipids in Health and Disease, 2023
Background Thermoxidation of edible oil through deep fat frying results in the generation of several oxidized products that promote lipid peroxidation and ROS production when eaten. Consumption of thermoxidized oil in post-menopausal conditions where the estrogen level is low contributes to cardiovascular disease. This study evaluates the role of estradiol and antihyperlipidemic agents (AHD) in restoring the vascular health of ovariectomized (OVX) rats fed with thermoxidized palm oil (TPO) and thermoxidized soya oil (TSO) diets. Method A total of 10 groups of rats (n = 6) were set up for the experiment. Group I (normal control) rats were sham handled while other groups were OVX to bring about estrogen deficient post-menopausal state. Group II (OVX only) was not treated and received normal rat chow. Groups III-X were fed with either TPO or TSO diet for 12 weeks and treated with estradiol (ETD) 0.2 mg/kg/day, atorvastatin (ATV) 10 mg/kg/day, and a fixed-dose combination of ezetimibe and ATV (EZE 3 mg/kg/day + ATV 10 mg/kg/day). Results Pro-atherogenic lipids levels were significantly elevated in untreated TSO and TPO groups compared to OVX and sham, resulting in increased atherogenic and Coronary-risk indices. Treatment with Estradiol and AHDs significantly reduced the total cholesterol, triglycerides, low-density lipoprotein cholesterol as well as AI and CRI compared to untreated TSO and TPO groups, whereas TSO and TPO groups showed significant elevation in these parameters compared to Group I values. Moreover, aortic TNF-α levels were extremely elevated in the untreated TSO and TPO compared to Group I. TNF-α levels were significantly reduced in rats treated with AHDs and ETD. Localized oxidative stress was indicated in the aortic tissues of TSO and TPO-fed OVX rats by increased malondialdehyde and decreased glutathione, catalase, and superoxide dismutase levels. This contributed to a depletion in aortic nitric oxide. AHDs and ETD replenished the nitric oxide levels significantly. Histological evaluation of the aorta of TSO and TPO rats revealed increased peri-adventitia fat, aortic medial hypertrophy, and aortic recanalization. These pathologic changes were less seen in AHDs and ETD rats. Conclusion This study suggests that ETD and AHDs profoundly attenuate oxidized lipid-induced vascular inflammation and atherogenesis through oxidative-stress reduction and inhibition of TNF-α signaling.
Comparative Therapeutic Effect of Single/Combined Administration of Saxagliptin, Metformin and Intranasal Insulin on Dexamethasone Induced Insulin Resistance in Wistar Rat Model
Jephtah Oche, Olufunke Olorundare, Saheed Afolabi, Mary Ologe, Anoka Njan, et al.
Nigerian Journal of Physiological Sciences, 2023
Glucocorticoids have therapeutic benefits in the management of several inflammatory and immunological disorders. Despite these medicinal effects, they have the drawback of causing metabolic disorders such as hyperglycemia, insulin resistance etc., which is known to be a key indicator of metabolic syndrome. Metabolic syndrome is a major predisposing factor to type 2 diabetes mellitus and cardiomyopathy. This study was designed to compare and evaluate the effects of saxagliptin, metformin and intranasal insulin (when used singly or in combination) on dexamethasone induced insulin resistance. Fifty-six female rats were randomly assigned into eight groups. Group 1 represented the control; Group 2 was administered with dexamethasone (1mg/kg) (untreated); Group 3 received dexamethasone + intranasal insulin (2IU); Group 4 received dexamethasone + intranasal insulin + metformin (40mg/kg); Group 5; received dexamethasone + intranasal + saxagliptin (8mg/kg); Group 6 received dexamethasone + metformin (40mg/kg); Group 7 received dexamethasone + saxagliptin (8mg/kg); Group 8 received dexamethasone + saxagliptin(8mg/kg) + metformin(40mg/kg). Treatments were given for one week. At the end of the study, blood samples were collected for biochemical assays and pancreas excised for histological examination. Dexamethasone (1mg/kg) induced hyperglycemia, hyperinsulinemia, dyslipidemia, impaired glucose tolerance and disrupted the structural integrity of the pancreas. Treatment with saxagliptin, metformin and their combination significantly decreased blood glucose level, decreased LDL Level and improved glucose tolerance. The selected hypoglycemic agents used in present study ameliorate the dexamethasone induced hyperglycemia and insulin resistance of which the combination of metformin with saxagliptin showed greater efficacy.
Identification of neurotherapeutic constituents in Ocimum gratissimum with cholinesterase and mono amine oxidase inhibitory activities, using GC-MS analysis, in vitro, and in silico approaches
Anoka A. Njan, Esther O. Olaleye, Saheed O. Afolabi, Immanuel Anoka-Ayembe, Gideon A. Gyebi, et al.
Informatics in Medicine Unlocked, 2023
Antimalarial phytochemicals as potential inhibitors of SARS-CoV-2 guanine N7-methyltransferase (nsp 14): an integrated computational approach
Gideon A. Gyebi, Oludare M. Ogunyemi, Adedotun A. Adefolalu, Juan F. López-Pastor, Antonio J. Banegas-Luna, et al.
Journal of Biomolecular Structure and Dynamics, 2023
The inhibition of capping enzymes such as guanine-N7-methyltransferase (GMT) is an attractive target for regulating viral replication, transcription, virulence, and pathogenesis. Thus, compounds that target the Severe Acute Respiratory Syndrome Corona Virus 2 GMT (S2GMT) will enhance drug development against COVID-19. In this study, an in-house library of 249 phytochemicals from African medicinal plants was screened using computational approaches including homology modeling, molecular docking, molecular dynamic simulations, binding free energy calculations based on molecular mechanics/Poisson-Boltzmann surface area (MMPBSA) and Absorption-Distribution-Metabolism-Excretion-Toxicity (ADMET) analysis for inhibitors of S2GMT. The top-ten ranked phytochemicals (TTRP) obtained from the docking analysis to S2GMT were further docked to SARS-COV N7-MTase. Among the TTRP, the top-four ranked phytocompounds (TFRP) viz: 3 alkaloids (Isocryptolepine, 10'-Hydroxyusambarensine and Isostrychnopentamine) and a flavonoid (Mulberrofuran F) interacted strongly with critical catalytic residues whose interference either reduce or completely abolish N7-MTase activity, indicating their potential as capping machinery disruptors. The interactions of TFRP with the catalytic residues of S2GMT were preserved in a 100 ns simulated dynamic environment, thereby, demonstrating high degree of structural stability. The MMPBSA binding free energy calculations corroborated the docking scores with biscryptolepine having the highest binding free energy to S2GMT. The TFRP showed favourable drug-likeness and ADMET properties over a wide range of molecular descriptors. Therefore, the TFRP can be further explored as potential S2GMT inhibitors in in vitro and in vivo experiments.Communicated by Ramaswamy H. Sarma.
African derived phytocompounds may interfere with SARS-CoV-2 RNA capping machinery via inhibition of 2′-O-ribose methyltransferase: An in silico perspective
Gideon A. Gyebi, Oludare M. Ogunyemi, Adedotun A. Adefolalu, Alejandro Rodríguez-Martínez, Juan F. López-Pastor, et al.
Journal of Molecular Structure, 2022
Prevention of SARS-CoV-2 cell entry: insight from in silico interaction of drug-like alkaloids with spike glycoprotein, human ACE2, and TMPRSS2
Gideon A. Gyebi, Adegbenro P. Adegunloye, Ibrahim M. Ibrahim, Oludare M. Ogunyemi, Saheed O. Afolabi, et al.
Journal of Biomolecular Structure and Dynamics, 2022
SARS-CoV-2 host cell entry: an in silico investigation of potential inhibitory roles of terpenoids
Gideon A. Gyebi, Oludare M. Ogunyemi, Ibrahim M. Ibrahim, Olalekan B. Ogunro, Adegbenro P. Adegunloye, et al.
Journal of Genetic Engineering and Biotechnology, 2021
Dual targeting of cytokine storm and viral replication in COVID-19 by plant-derived steroidal pregnanes: An in silico perspective
Gideon A. Gyebi, Oludare M. Ogunyemi, Ibrahim M. Ibrahim, Saheed O. Afolabi, Joseph O. Adebayo
Computers in Biology and Medicine, 2021
Antidiabetic and antihyperlipidemic effects of aqueous extract of Parquetina nigrescens in streptozotocin–nicotinamide induced type 2 diabetic rats
Fatimoh Idowu Ojuade, Olufunke Esan Olorundare, Olatunde Babatunde Akanbi, Saheed Olanrewaju Afolabi, Anoka Ayembe Njan
Heliyon, 2021
Screening of Selected Nigerian Medicinal Plants/Seeds for Growth Inhibitory Activity against Human Leukemia HL-60 Cells and DPPH Radical Scavenging Activity
African Journal of Biomedical Research, 2021
Potential inhibitors of coronavirus 3-chymotrypsin-like protease (3CLpro): an in silico screening of alkaloids and terpenoids from African medicinal plants
Gideon A. Gyebi, Olalekan B. Ogunro, Adegbenro P. Adegunloye, Oludare M. Ogunyemi, Saheed O. Afolabi
Journal of Biomolecular Structure and Dynamics, 2021
Subchronic exposure to Kafura; its neurotoxic potentials in young adult female Wistar rats
Anoka A. Njan, Mary O. Ologe, Olufunke E. Olorundare, Saheed O. Afolabi, Benjamin C. Ejimkonye, et al.
Heliyon, 2020
Alkaloids and flavonoids from African phytochemicals as potential inhibitors of SARS-Cov-2 RNA-dependent RNA polymerase: an in silico perspective
Oludare M Ogunyemi, Gideon A Gyebi, Abdo A Elfiky, Saheed O Afolabi, Olalekan B Ogunro, et al.
Antiviral Chemistry and Chemotherapy, 2020
Safety effect of fractions from methanolic leaf extract of Ocimum gratissimum on reproduction in male wistar rats
Anoka A. Njan, Solomon O. Olaoye, Saheed O. Afolabi, Benjamen C Ejimkonye, Anthonia Soje, et al.
Toxicology Reports, 2019
Polyalthia longifolia Extract Triggers ER Stress in Prostate Cancer Cells Concomitant with Induction of Apoptosis: Insights from in Vitro and in Vivo Studies
Saheed O. Afolabi, Olufunke E. Olorundare, Abiola Babatunde, Ralph M. Albrecht, Mamoru Koketsu, et al.
Oxidative Medicine and Cellular Longevity, 2019
Fisetin targets YB-1/RSK axis independent of its effect on ERK signaling: insights from in vitro and in vivo melanoma models
Mario Sechi, Rahul K. Lall, Saheed O Afolabi, Anant Singh, Dinesh C. Joshi, et al.
Scientific Reports, 2018
Comparative antileukemic activity of a tetranorditerpene isolated from polyalthia longifolia leaves and the derivative against human leukemia HL-60 cells
Saheed Afolabi, Olufunke Olorundare, Masayuki Ninomiya, Abiola Babatunde, Hasan Mukhtar, et al.
Journal of Oleo Science, 2017
A 90 day chronic toxicity study of Nigerian herbal preparation DAS-77 in rats
Saheed O Afolabi, Abidemi J Akindele, Olufunsho Awodele, Chidozie C Anunobi, Olufunmilayo O Adeyemi
BMC Complementary and Alternative Medicine, 2012

RECENT SCHOLAR PUBLICATIONS

Gastroprotective effect of locally formulated Nigerian herbal supplement from 5 plants
SO Afolabi, GA Gyebi, OE Raji, Damilola & Olorundare
Science World Journal 21 (1), 115-120 , 2026
2026
Correction to “Polyalthia longifolia Extract Triggers ER Stress in Prostate Cancer Cells Concomitant with Induction of Apoptosis: Insights from In Vitro and In Vivo Studies”
SO Afolabi, OE Olorundare, A Babatunde
2026
Toxicological Assessment of the Moringa Species: A Minireview
SO Afolabi, H Adeleye, W Okan, O Asuku, S Oladimeji, FR Babalola, ...
Journal of Anatomical Sciences 17 (1), 203-213 , 2026
2026
Recent Trends in Heavy Metal Poisoning and Management: A Concise Review
S Afolabi, S Oloyede, A Adeosun, I Funsho, O Rotimi, Y Hassanat, A Njan
Journal of Anatomical Sciences 17 (1), 221-231 , 2026
2026
SEX-SPECIFIC SUB-ACUTE TOXICITY AND IMMUNOMODULATORY PROFILE OF A NIGERIAN POLYHERBAL SUPPLEMENT (NAPHERBS) IN ALBINO WISTAR RATS
SO Afolabi, O Olorundare, O Akanbi, S Ibiyemi
Nigerian Journal of Physiological Sciences 40 (2), https://doi.org/10.54548/ , 2025
2025
Comparative effects of alternate tobacco products and traditional tobacco smoking on various organ/systems: A guide to regulators and health policy makers
SO Afolabi, SO Olaoye, A Nyamgee, AA Njan
Toxicology Reports 15, 102100 , 2025
2025
Citations: 2
Protective Effect of Pleurotus tuberregium Polysaccharide (PTP) and Ganoderma lucidum Polysaccharide (GLP) on Lead-Induced Testicular Derangement in Rats
MO Sobowale, OE Olorundare, SO Afolabi, AM Ajayi, JT Aghogho
Pharmacology and Toxicology of Natural Medicines (ISSN: 2756-6838) 5 (3-4 … , 2025
2025
Sub-Acute Toxicological Evaluation of An Artemesia-Based Moringa Supplement (AMS)
SO Afolabi, OE Olorundare, OB Akanbi, MK Bello, JT Folahan, S Ibiyemi
The Tropical Journal of Health Sciences 32 (2), 32-38 , 2025
2025
Apoptotic Potential of Iloneoside from Gongronema latifolium Benth against Prostate Cancer Cells Using In Vitro and In Silico Approach
GA Gyebi, SO Afolabi, OM Ogunyemi, IM Ibrahim, OE Olorundare, ...
Cell Biochemistry and Biophysics 83 (1), 755-776 , 2025
2025
Citations: 2
Cholinergic Inhibition and Antioxidant Potential of Gongronema latifolium Benth Leaf in Neurodegeneration: Experimental and In Silico Study
GA Gyebi, JC Ejoh, OM Ogunyemi, SO Afolabi, IM Ibrahim, GO Anyanwu, ...
Cell Biochemistry and Biophysics 83 (1), 1-23 , 2025
2025
Citations: 10
Alleviation of oxidized lipid-induced oxidative stress and hypertension by estrogen and selected antihyperlipidemic drugs in post-menopausal Wistar rats
JT Folahan, AO Oyewopo, OA Adejumobi, AM Ajayi, SO Afolabi, O Atolani, ...
INNOSC Theranostics and Pharmacological Sciences 7 (4), 3901 , 2024
2024
Mechanisms of stretch-induced electro-anatomical remodeling and atrial arrhythmogenesis
RY Medvedev, SO Afolabi, DGP Turner, AV Glukhov
Journal of molecular and cellular cardiology 193, 11-24 , 2024
2024
Citations: 18
Hazard assessment and cytogenotoxic effect of different concentrations of mercury chloride sterilant using the Allium cepa assay
DA Animasaun, PA Adedibu, SO Afolabi, KA Abdulkareem, S Ibrahim, ...
Discover Toxicology 1 (1), 2 , 2024
2024
Citations: 19
Identification of potential inhibitors of cholinergic and β-secretase enzymes from phytochemicals derived from Gongronema latifolium Benth leaf: an integrated …
GA Gyebi, OM Ogunyemi, IM Ibrahim, OB Ogunro, SO Afolabi, RJ Ojo, ...
Molecular Diversity 28 (3), 1305-1322 , 2024
2024
Citations: 17
Hazzard assessment and cytogenotoxic effects of different concentrations of mercury chloride sterilant using an onion (Allium cepa) assay
DA ANIMASAUN, PA ADEDIBU, SO AFOLABI, KA ABDULKAREEM, ...
2024
GC/MS Analysis and a 30-day Toxicological Evaluation of a Nigerian Immunomodulatory Polyherbal Supplement (PHS)
SO Afolabi, O Olorundare, OB Akanbi, MK Bello, A Njan, OA Agede, ...
Pharmacology and Toxicology of Natural Medicines (ISSN: 2756-6838) 3 (2), 1-14 , 2023
2023
Citations: 2
Probing the multitargeting potential of n -hexane fraction of Gongronema latifolium leaves in neurodegeneration via in vitro, GC–MS and in silico studies
GA Gyebi, JC Ejoh, OM Ogunyemi, AM Ibrahim, IM Ibrahim, SO Afolabi, ...
Future Journal of Pharmaceutical Sciences 9 (1), 84 , 2023
2023
Citations: 6
Oxidized dietary lipids induce vascular inflammation and atherogenesis in post-menopausal rats: estradiol and selected antihyperlipidemic drugs restore vascular health in vivo
JT Folahan, OE Olorundare, AM Ajayi, AO Oyewopo, SS Soyemi, ...
Lipids in Health and Disease 22 (1), 107 , 2023
2023
Citations: 8
Antimalarial phytochemicals as potential inhibitors of SARS-CoV-2 guanine N7-methyltransferase (nsp 14): an integrated computational approach
GA Gyebi, OM Ogunyemi, AA Adefolalu, JF Lopez-Pastor, ...
Journal of Biomolecular Structure and Dynamics 41 (11), 5022-5044 , 2023
2023
Citations: 4
Comparative therapeutic effect of single/combined administration of saxagliptin, metformin and intranasal insulin on dexamethasone induced insulin resistance in albino wistar …
J Oche, O Olorundare, S Afolabi, M Ologe, A Njan, O Akanbi
Niger J Physiol Sci 38 (1), 37-46 , 2023
2023
Citations: 9

MOST CITED SCHOLAR PUBLICATIONS

Potential inhibitors of coronavirus 3-chymotrypsin-like protease (3CL pro ): an in silico screening of alkaloids and terpenoids from African medicinal plants
GA Gyebi, OB Ogunro, AP Adegunloye, OM Ogunyemi, SO Afolabi
Journal of Biomolecular Structure and Dynamics 39 (9), 3396-3408 , 2021
2021
Citations: 292
Inhibition mechanism of alpha-amylase, a diabetes target, by a steroidal pregnane and pregnane glycosides derived from Gongronema latifolium Benth
OM Ogunyemi, GA Gyebi, A Saheed, J Paul, V Nwaneri-Chidozie, ...
Frontiers in molecular biosciences 9, 866719 , 2022
2022
Citations: 123
Fisetin targets YB-1/RSK axis independent of its effect on ERK signaling: insights from in vitro and in vivo melanoma models
M Sechi, RK Lall, SO Afolabi, A Singh, DC Joshi, SY Chiu, H Mukhtar, ...
Scientific reports 8 (1), 15726 , 2018
2018
Citations: 58
A 90 day chronic toxicity study of Nigerian herbal preparation DAS-77 in rats
SO Afolabi, AJ Akindele, O Awodele, CC Anunobi, OO Adeyemi
BMC complementary and alternative medicine 12 (1), 79 , 2012
2012
Citations: 56
Prevention of SARS-CoV-2 cell entry: insight from in silico interaction of drug-like alkaloids with spike glycoprotein, human ACE2, and TMPRSS2
GA Gyebi, AP Adegunloye, IM Ibrahim, OM Ogunyemi, SO Afolabi, ...
Journal of Biomolecular Structure and Dynamics 40 (5), 2121-2145 , 2022
2022
Citations: 54
Alkaloids and flavonoids from African phytochemicals as potential inhibitors of SARS-Cov-2 RNA-dependent RNA polymerase: an in silico perspective
OM Ogunyemi, GA Gyebi, AA Elfiky, SO Afolabi, OB Ogunro, ...
Antiviral Chemistry and Chemotherapy 28, 2040206620984076 , 2020
2020
Citations: 38
Dual targeting of cytokine storm and viral replication in COVID-19 by plant-derived steroidal pregnanes: An in silico perspective
GA Gyebi, OM Ogunyemi, IM Ibrahim, SO Afolabi, JO Adebayo
Computers in Biology and Medicine 134, 104406 , 2021
2021
Citations: 35
Antidiabetic and antihyperlipidemic effects of aqueous extract of Parquetina nigrescens in streptozotocin–nicotinamide induced type 2 diabetic rats
FI Ojuade, OE Olorundare, OB Akanbi, SO Afolabi, AA Njan
Heliyon 7 (6) , 2021
2021
Citations: 30
Iloneoside: a cytotoxic ditigloylated pregnane glycoside from the leaves of Gongronema latifolium Benth
GA Gyebi, JO Adebayo, OE Olorundare, A Pardede, M Ninomiya, ...
Natural product research 32 (24), 2882-2886 , 2018
2018
Citations: 23
SARS-CoV-2 host cell entry: an in silico investigation of potential inhibitory roles of terpenoids
GA Gyebi, OM Ogunyemi, IM Ibrahim, OB Ogunro, AP Adegunloye, ...
Journal of Genetic Engineering and Biotechnology 19 (1), 113 , 2021
2021
Citations: 22
Safety effect of fractions from methanolic leaf extract of Ocimum gratissimum on reproduction in male wistar rats
AA Njan, SO Olaoye, SO Afolabi, BC Ejimkonye, A Soje, OE Olorundare, ...
Toxicology reports 6, 496-504 , 2019
2019
Citations: 21
Hazard assessment and cytogenotoxic effect of different concentrations of mercury chloride sterilant using the Allium cepa assay
DA Animasaun, PA Adedibu, SO Afolabi, KA Abdulkareem, S Ibrahim, ...
Discover Toxicology 1 (1), 2 , 2024
2024
Citations: 19
Polyalthia longifolia Extract Triggers ER Stress in Prostate Cancer Cells Concomitant with Induction of Apoptosis: Insights from In Vitro and In Vivo Studies
SO Afolabi, OE Olorundare, A Babatunde, RM Albrecht, M Koketsu, ...
Oxidative medicine and cellular longevity 2019 (1), 6726312 , 2019
2019
Citations: 19
Mechanisms of stretch-induced electro-anatomical remodeling and atrial arrhythmogenesis
RY Medvedev, SO Afolabi, DGP Turner, AV Glukhov
Journal of molecular and cellular cardiology 193, 11-24 , 2024
2024
Citations: 18
Identification of potential inhibitors of cholinergic and β-secretase enzymes from phytochemicals derived from Gongronema latifolium Benth leaf: an integrated …
GA Gyebi, OM Ogunyemi, IM Ibrahim, OB Ogunro, SO Afolabi, RJ Ojo, ...
Molecular Diversity 28 (3), 1305-1322 , 2024
2024
Citations: 17
African derived phytocompounds may interfere with SARS-CoV-2 RNA capping machinery via inhibition of 2′-O-ribose methyltransferase: An in silico perspective
GA Gyebi, OM Ogunyemi, AA Adefolalu, A Rodriguez-Martinez, ...
Journal of Molecular Structure 1262, 133019 , 2022
2022
Citations: 17
Inhibitory potentials of phytocompounds from Ocimum gratissimum against anti-apoptotic BCL-2 proteins associated with cancer: an integrated computational study
G A. Gyebi, O M. Ogunyemi, I M. Ibrahim, S O. Afolabi, R J. Ojo, U DI Ejike, ...
Egyptian Journal of Basic and Applied Sciences 9 (1), 588-608 , 2022
2022
Citations: 15
Cytotoxic Potentials of Clerodendrum Volubile against Prostate Cancer Cells and Its Possible Proteomic Targets
S Afolabi, O Olorundare, G Gyebi, DN Syed, H Mukhtar, R Albrecht, ...
Journal of Clinical Nutrition and Food Science 2 (1), 046-053 , 2019
2019
Citations: 13
Comparative antileukemic activity of a tetranorditerpene isolated from Polyalthia longifolia leaves and the derivative against human leukemia HL-60 cells
S Afolabi, O Olorundare, M Ninomiya, A Babatunde, H Mukhtar, ...
Journal of Oleo Science 66 (10), 1169-1174 , 2017
2017
Citations: 12
Identification of neurotherapeutic constituents in Ocimum gratissimum with cholinesterase and mono amine oxidase inhibitory activities, using GC-MS analysis, in vitro, and in …
AA Njan, EO Olaleye, SO Afolabi, I Anoka-Ayembe, GA Gyebi, ...
Informatics in Medicine Unlocked 39, 101261 , 2023
2023
Citations: 11

Saheed Olanrewaju Afolabi

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Scopus Publications

RECENT SCHOLAR PUBLICATIONS

MOST CITED SCHOLAR PUBLICATIONS