Idayat Adenike Durotoye
@unilorin.edu.ng
Associate Professor, Faculty of Basic Clinical Sciences
University of Ilorin, Ilorin, Nigeria
Idayat Adenike DUROTOYE is an Associate Professor, in the Department of Haematology, Faculty of Basic Clinical Sciences, University of Ilorin, Ilorin, Nigeria. She has over 15 years of Teaching and research experience in Haematology with special interest in Haemoglobinopathies, Transfusion Medicine and Haemostasis. She has served as the Head of Department, Sub-Dean, Chairman Coronavirus Prevention Committee, Chairman College Welfare Committee and Faculty representative. She has supervised and co-supervised 9 Resident Doctors all of whom are Consultant Haematologists. She has over 40 publications to her credit. She and her Colleagues have won multi-million grants. She is a reviewer for reputable journals like Tropical Journal of Health Sciences, Nigeria Medical Journal of Medicine and Ethiopian Medical Journal. She is a member of many Professional bodies within and outside Nigeria. Her current research activities are focused on Blood Safety and Blood sufficiency to meet World Health Or
RESEARCH, TEACHING, or OTHER INTERESTS
Hematology, Hematology
Scopus Publications
Scholar Citations
Scholar h-index
Scholar i10-index
Scopus Publications
Hannah Oluwayemisi Olawumi, Foluke Atinuke Fasola, Theresa Ize Otu, Ngozi Immaculata Ugwu, Idayat Adenike Durotoye, Khadijat Olaitan Omokanye, Mutiat Kehinde Ogunfemi, Ifeoma Patience Ijei‐Enesi, Aisha Mohammed Abba, Ulunma Ikwuoma Mariere,et al.
Wiley
AbstractBackground and ObjectivesWomen are grossly under‐represented among blood donors in Nigeria. We, therefore, determined the barriers, motivators and appealing incentives to blood donation among women in Nigeria.Materials and MethodsThis was an internet‐based cross‐sectional study among women aged 18–65 years. A well‐structured questionnaire was used to determine sociodemographic characteristics, motivation, barriers and appealing incentives. Motivational and barrier differences in some sociodemographic characteristics were determined using the chi‐squared test. A p‐value of 0.05 was considered statistically significant.ResultsThe most common motivators among blood donors were ‘when family or friend is in need of blood’, ‘health benefits’ and ‘reminders to donate’. One‐time donors who were willing to become regular donors were more motivated by reminders to donate than those not willing (p = 0.000). The most common barriers among non‐donors were ‘poor attitude of hospital staff’ and ‘fear of contracting infections’. Younger women and those of the Hausa tribe were more debarred by ‘lack of privacy during blood donation exercise’ than older women and those of the other tribes (p‐values of 0.008 and 0.006, respectively). The most appealing incentives for blood donation were medical consultation and a blood donation certificate.ConclusionWomen's participation in blood donation in Nigeria can be improved by sending regular reminders to donors, especially one‐time donors and by infrastructural adjustments to improve privacy at the blood donation sites. Specific and targeted capacity‐building initiatives should also be put in place to drive a paradigm shift in the attitude of hospital staff to work in Nigeria.
Oluwapelumi Olufemi Adeyemi, Nnaemeka Darlington Ndodo, Mariam Kehinde Sulaiman, Oyeronke Temidayo Ayansola, Oluwabunmi Idera Nimat Buhari, Olusola Anuoluwapo Akanbi, Oladimeji Akeem Bolarinwa, Chimaobi Chukwu, Ireoluwa Yinka Joel, Adesuyi Ayodeji Omoare,et al.
Public Library of Science (PLoS)
The COVID-19 global pandemic is being driven by evolving SARS-CoV-2 variants with consequential implications on virus transmissibility, host immunity, and disease severity. Continuous molecular and genomic surveillance of the SARS-CoV-2 variants is therefore necessary for public health interventions toward the management of the pandemic. This study is a retrospective analysis of COVID-19 cases reported in a Nigerian tertiary institution from July to December 2021. In total, 705 suspected COVID-19 cases that comprised 547 students and 158 non-students were investigated by real time PCR (RT-PCR); of which 372 (~52.8%) tested positive for COVID-19. Using a set of selection criteria, 74 (~19.9%) COVID-19 positive samples were selected for next generation sequencing. Data showed that there were two outbreaks of COVID-19 within the university community over the study period, during which more females (56.8%) tested positive than males (47.8%) (p<0.05). Clinical data together with phylogenetic analysis suggested community transmission of SARS-CoV-2 through mostly asymptomatic and/or pre-symptomatic individuals. Confirmed COVID-19 cases were mostly mild, however, SARS-CoV-2 delta (77%) and omicron (4.1%) variants were implicated as major drivers of respective waves of infections during the study period. This study highlights the importance of integrated surveillance of communicable disease during outbreaks.
Emmanuel O Sanni, Hannah O Olawumi, Idayat A Durotoye, Timothy O Olanrewaju, Abiola S Babatunde, Olasunkanmi A Shittu, Sikiru A Biliaminu, Khadijat O Omokanye, Mutiat Kehinde Ogunfemi, Olabisi O Akinwumi,et al.
African Journals Online (AJOL)
Background: Functional iron deficiency has been found to be a common cause of poor response to erythropoiesis stimulating agents in anaemic patients with chronic kidney disease (CKD).
 Objectives: Assess the functional iron status of patients with chronic kidney disease.
 Methods: This was a hospital based cross sectional study. The study subjects were chronic kidney disease patients with age and sex matched healthy controls. Full blood count, serum ferritin, soluble transferring receptor, C-reactive protein, serum iron and total iron binding capacity were measured in the patients and healthy controls. Data was analyzed with statistical package for the social sciences software version 22.0. And the level of statistical significance was set at p. value < 0.05.
 Results: The mean ± SD of the age of patient with CKD was 55.0 + 15.4 years, while that of controls was 52.7 + 13.6 years. The mean serum ferritin, serum iron, TIBC and CRP were significantly higher in patients compared with controls (p<0.001, 0.023, <0.001 and 0.001) respectively. Functional iron deficiency was seen in 19.5% of patients with CKD.
 Conclusion: The predominant form of iron deficiency in our study was functional iron deficiency.
 Keywords: Chronic kidney disease; functional iron status; anaemia.
Ogochukwu O. Izuegbuna, Hannah O. Olawumi, Samuel A. Olatoke, and Idayat Durotoye
Informa UK Limited
Abstract Aim To assess the relationship between nutritional status and inflammatory markers of breast cancer patients, and to identify predictors of malnutrition in these patients. Methods This is a cross-sectional study of 45 patients with breast cancer assessed between January and June 2018. Nutritional status was evaluated by objective and subjective methods. The inflammatory markers and inflammation-based scores evaluated were C-reactive protein (CRP), albumin, erythrocyte sedimentation rate (ESR), Glasgow Prognostic Score (GPS), CRP/albumin ratio, and Albumin/CRP ratio. Results A total of 45 patients were evaluated. Majority of the patients have high levels of both CRP and ESR (73.3% and 86.7% respectively). More than 70% of the patients were well nourished. There was no significant association between CRP (P = 0.067), ESR (P = 0.094) and SGA (Subjective Global Assessment) categories. Albumin (P < 0.001), Albumin/CRP ratio (P = 0.002), CRP/albumin ratio (P = < 0.001), and GPS (P < 0.001) were significantly associated with SGA categories. On multivariate analysis, albumin (P < 0.001), Albumin/CRP ratio (P = 0.004), CRP/albumin ratio (P = 0.009), GPS (P = 0.01), and ECOG (P = 0.009) were the only markers independently related to malnutrition. Conclusion The inflammation-based scores were significantly associated with malnutrition and can be used as biochemical nutritional assessment tools in cancer patients.
Idayat Durotoye, Rasheed Odunola, Oluwapelumi Adeyemi, Alex Akanmu, Oladimeji Bolarinwa, Muhammed Adeboye, Ali Abdullahi, Zulkarnain Bolajoko, Wasiu Durosinmi, George Adebisi,et al.
Wiley
An outbreak of Coronavirus Disease 2019 (COVID-19) was first reported from Wuhan, China in December 2019. The rapid spread of COVID-19 principally through respiratory droplets and fomites transitioned into a global pandemic in waves of outbreaks across regions. 1 The projected colossal impact of the pandemic on economies particu-larly in low to middle income countries (LMIC), 2 have prompted pertinent questions about Africa's preparedness. 3 This report highlights early responses of a Nigerian institution to the COVID-19 pandemic. The University of Ilorin (Unilorin), Ilorin, Nigeria is an international institution of higher learning, which was established by the Nigerian Government in 1976. It occupies a 15 000-ha landmass that cuts across several rural communities in Kwara State, North-central Nigeria and 180 miles (289.7 km) from the Lagos epicenter of the COVID-19 outbreak in Nigeria. The Unilorin community comprises over 4500 workers and 56 600 students across 15 faculties, one College of Health Sciences, and a School of Preliminary Studies. Following the first reported case of COVID-19 in Lagos, Nigeria, a COVID-19 Prevention Committee (herein referred to as The Committee ) was setup by the University management to safeguard the University community. Within 3 weeks of the COVID-19 outbreak in Nigeria, the committee successfully implemented a string of containment measures before the first confirmed case was reported in Ilorin, Kwara State. The sweeping impact of COVID-19 on healthcare facilities across climes, emphasizes the importance of early preparation of healthcare facilities. 4 The Unilorin health services was setup to meet the health needs of students and staff of the University community within a clinic facility that operates in collaboration with the University of Ilorin Teaching Hospital, where cases that require specialist's attention are referred. Within the week of the outbreak of COVID-19 in Nigeria, the University clinic operations were modified to meet the imminent challenges of the epidemic. Routine and nonemergency visits to the University Healthcare Center were
Oluwatosin Oladosu-olayiwola, Hannah Olawumi, Abiola Babatunde, Munirdeen Ijaiya, Idayat Durotoye, Sikiru Biliaminu, and Rasheedat Ibraheem
African Journals Online (AJOL)
Background The hypercoagulability of pregnancy is exaggerated in pre-eclamptic state because of endothelial activation with resultant production of some endothelial derived proteins that are said to be inhibitors of fibrinolysis. This study compares these proteins like tPA, PAI-1 and D-dimers in normal pregnant women and the pre-eclamptic women. Methodology This was a comparative cross-sectional study. Eighty-five pre-eclamptic women were recruited as subjects and eighty five age, trimester and parity matched normotensive pregnant women as controls. Levels of PT, aPTT, tPA, PAI-1, D-dimer protein were determined in blood samples of subjects and controls. Urinalysis was performed with dipstick method on their urine samples. Data generated was analysed using the IBM®SPSS 20.0 (2011) soft ware packages and the level of significance was a p-value <0.05. Results The mean age of the respondents was 29.9±5.2 years. The median(25th–75th percentile) values of D-dimer, tPA, and PAI-1 of subjects were 730 (305.000–1560.000ng/ml), 0.11 (0.065–0,300ng/ml) and 3.65 (2.970–4,400ng/ml) respectively which were significantly higher than the corresponding values in the controls of 520 (24.000–1030.000ng/ml), 0.05 (0.040–0.090ng/ml and 2.650 (2.125–3.400ng/ml) respectively, p<0.05 each. Conclusion The abnormal levels of PAI-1, D-dimer and tPA imply that they contribute to the exaggerated hypercoagulabilty state in pre-eclampsia thus, measuring their levels can help in the management of the condition.
J. K. Afolabi, A. Fadeyi, O. O. Desalu, I. A. Durotoye, A. E. Fawibe, M. A. N. Adeboye, H. O. Olawumi, A. S. Babatunde, S. K. Ernest, S. A. Aderibigbe,et al.
SAGE Publications
Background: For the establishment and monitoring of the immune status, CD4 count is critical. Objectives: To determine the CD4 count range of apparently healthy Nigerians resident in Ilorin and compare with the national value. Methods: An automated blood analyzer was used to determine the full blood count and CD4 count. The percentage of CD4 count was derived by using other variables. Results: Of the 1205 participants, the reference CD4 count (percentage of CD4) range for adult was 400 to 1288 cells/mm3 (19%-48%) and for children was 582 to 3652 cells/mm3 (17%-50%). CD4 count and percentage of CD4 were significantly ( P = .001) higher in females than in males, and the CD4 count declined significantly with increasing age ( r = −.174, P ≤ .0001). The percentage of CD4 count shows less variation with age ( r = −.051, P = .076). Adult residents of Ilorin had significantly lower absolute mean CD4 count (808 ± 260) than that of the national reference values of 847.0 ± 307.0 cells/mm3 ( P = .001). Conclusion: We therefore advocate the use of CD4 count range derived in this study is lower than that of the national reference values.
Mutiat K. Ogunfemi, Hannah O. Olawumi, Abdulfatai B. Olokoba, Modu B. Kagu, Sikiru A. Biliaminu, Kabir A. Durowade, Idayat A. Durotoye, and Akeem O. Shittu
African Journals Online (AJOL)
HO Olawumi, DO Olanrewaju, AO Shittu, IA Durotoye, AA Akande, and A Nyamngee
African Journals Online (AJOL)
BACKGROUND
Human immunodeficiency virus (HIV) and Hepatitis B virus (HBV) share similar routes of transmission, making it possible for an individual to have a co-infection. HBV infection is well known to be a major cause of chronic liver diseases worldwide. The aim of this study was to determine the prevalence of HBV infection among HIV infected HAART naïve patients and investigate the effect of co-infection on CD4 count and liver function.
STUDY DESIGN
This was a hospital based descriptive cross sectional study of one hundred consecutive therapy-naive HIV-infected individuals. The CD4 count, Hepatitis B surface antigen, Serum albumin, total Protein, and liver enzymes were determined using standard techniques.
RESULTS
The prevalence of HIV and HBV co-infection was 37%. The mean serum ALT and ALP were significantly higher in the co- infected patients (P-values <0.05). The mean CD4 count of the mono infected patients was significantly higher (p-value of 0.014). The mean serum ALT, AST and ALP of mono and co-infected patients with CD4 count<200/µl were significantly higher than those with count ≥ 200 cells/µl. (p-value of <0.01). The mean ALT and AST of the co-infected patients and all patients with CD4 count <200 cells/µl were higher than the normal reference range.
CONCLUSION
Approximately one third of HIV positive patients had hepatitis B virus co-infection. Co-infection and CD4 count <200 cells/µl are likely to result in abnormal ALT and AST. We recommend that co-infected patients and those with CD4 count <200 cells/µl should be given non-hepatotoxic antiretroviral drug.
Abiola Samuel Babatunde, Aishatu Ahmed Gobir, Mohammed Akanbi Nurudeen Adeboye, Abdulganiy Adebayo-Oloko, and Idayat Adenike Durotoye
Bangladesh Journals Online (JOL)
Objective: The study was carried out to document the pattern of childhood malignant tumors which were diagnosed at the University of Ilorin Teaching Hospital, Ilorin, and compare with previous reports from other parts of Nigeria and elsewhere and also highlight the challenges and strategies for effective management of these diseases in our environment. Methods: A ten year retrospective analysis of all cancers diagnosed in children below the age of 18 years at the study centre between January 2000 and December 2009 was carried out. Case folders of all children diagnosed with malignant tumors within the study period were retrieved from the Cancer Registry Department of the Hospital and were analyzed with respect to age, gender, morphological or histological type of malignancy, extent of disease, treatment modality, and survival outcome. Results: Ninety nine (99) children were diagnosed with various malignancies during the study period. Sixty seven (67; 67.7%) were boys and 32 (32.3%) were girls giving a male to female ratio of 2:1. There were 22 cases (22.2%) recorded in children aged below 4 years and 72 cases (72.7%) were diagnosed in children between 4-14 years. Lymphomas were the most prevalent malignancies encountered accounting for 54 cases (54.5%), Burkitts lymphoma constituted 43 (79.6%) of all lymphoma cases. The distribution of the five foremost malignancies recorded were as follows: Burkitts lymphoma (43 cases), Nephroblastoma (10 cases), Retinoblastoma (8 cases), Non Hodgkins lymphoma (7 cases) and Acute leukaemias (5 cases). Other malignancies included Osteogenic sarcoma (5), Hodgkins lymphoma (4), and 2 cases each of primary liver cell carcinoma, neuroblastoma, rhabdomyosarcoma and nasopharyngeal tumor. Conclusion: The distribution of the various childhood malignant tumors recorded in this study is similar to the pattern reported in previous studies from Nigeria and other countries. However, there appears to be a lower prevalence of leukemia recorded in this study compared to the earlier findings. The challenges which were identified in the diagnosis, management and overall outcome of our patients included limited number of diagnostic tools, late presentation in the hospital, high patient default rate, poverty, and shortage of chemotherapeutic drugs.Bangladesh Journal of Medical Science Vol.14(3) 2015 p.241-246
IdayatA Durotoye, BabaA Issa, Abayomi Fadeyi, AbdullahD Yussuf, AlakijaK Salami, OlasunkanmiA Shittu, PeterO Ajiboye, HannahO Olawumi, OlusholaA Adegunloye, Charles Nwabuisi,et al.
Medknow
BACKGROUND
Mentally ill persons are vulnerable to sexually transmitted infections including hepatitis B and C because of their high level risky behaviors. This study is aimed at establishing the sero-prevalence of hepatitis B and C among the mentally ill individuals (MII) attending psychiatric clinic of the University of Ilorin Teaching Hospital (UITH), Nigeria since it has not been documented.
METHODS
A total of 350 MII were recruited. HBsAg testing was by immunoassay test strip (Grand Medical Diagnostic R USA) while hepatitis C was tested by commercially prepared kits from ACON, R USA. Healthy adults who presented as donors in the blood bank of the hospital were used as controls.
RESULTS
A total of 700 participants including 350 MII and 350 blood donors (BDs) were recruited for the study. The mean ages of MII and control participants were 36.5 ± 12.3 and 31.4 ± 8.3, respectively.The sero-prevalence of hepatitis B and C among patients with mental illness was 10.0 and 12.6%, respectively, as compared to 10.9% and 1.1% of the blood donors. There was a significant difference in the prevalence of HCV among mentally ill when compared with the blood donors (P = 0.001, χ2 = 33.97; OR (CI) =12.44 (5.33-29.03).
CONCLUSION
Mentally ill patients attending UITH were significantly infected with hepatitis C virus. There is need for interventional measures to reduce the prevalence of hepatitis C among the mentally ill population such as health education and early screening of mentally ill in our setting.
HO Olawumi, DO Olanrewaju, AO Shittu, IA Durotoye, AA Akande, and A Nyamngee
African Journals Online (AJOL)
BACKGROUND
Human immunodeficiency virus (HIV) and Hepatitis B virus (HBV) share similar routes of transmission making it possible for an individual to have a co-infection. HBV infection is well known to be a major cause of chronic liver diseases worldwide. The aim of this study was to determine the prevalence of HBV infection among HIV infected HAART naïve patients and investigate the effect of co-infection on CD4 count and liver function.
STUDY DESIGN
This was a hospital based descriptive cross sectional study of one hundred consecutive therapy-naive HIV-infected individuals. The CD4 count, Hepatitis B surface antigen. Serum albumin, total Protein, and liver enzymes were determined using standard techniques.
RESULTS
The prevalence of HIV and HBV co-infection was 37%. The mean serum ALT and ALP were significantly higher in the co-infected patients (P-values <0.05). The mean CD4 count of the mono infected patients was significantly higher (p-value of 0.014). The mean serum ALT, AST and ALP of mono and coinfected patients with CD4 count<200/µl were significantly higher than those with count ≥ 200 cells/µl. (p-value of <0.01). The mean ALT and AST of the co infected patients and all patients with CD4 count <200 cells/µl were higher than the normal reference range.
CONCLUSION
Approximately one third of HIV positive patients had hepatitis B virus co-infection. Co-infection and CD4 count <200 cells/µl are likely to result in abnormal ALT and AST. We recommend those co-infected patients and those with CD4 count <200 cells/µl should be given non-hepatotoxic antiretroviral drug.