Madison College, Madison, Wisconsin, USA.
University of Wisconsin-Madison, USA.
Singapore Postgraduate Medical Institute, Singapore General Hospital, Singapore.
National Postgraduate Medical College of Nigeria, Lagos, Nigeria.
University of Port Harcourt, Nigeria
RESEARCH, TEACHING, or OTHER INTERESTS
Hematology, Oncology, Medicine, Cancer Research
27
Scopus Publications
889
Scholar Citations
15
Scholar h-index
19
Scholar i10-index
Scopus Publications
A transcriptional network governing ceramide homeostasis establishes a cytokine-dependent developmental process Ruiqi Liao, Abiola Babatunde, Stephanie Qiu, Hamsini Harikumar, Joshua J. Coon, et al. Nature Communications, 2023 Transcriptional mechanisms controlling developmental processes establish and maintain proteomic networks, which can govern the levels of intracellular small molecules. Although dynamic changes in bioactive small molecules can link transcription factor and genome activity with cell state transitions, many mechanistic questions are unresolved. Using quantitative lipidomics and multiomics, we discover that the hematopoietic transcription factor GATA1 establishes ceramide homeostasis during erythroid differentiation by regulating genes encoding sphingolipid metabolic enzymes. Inhibiting a GATA1-induced sphingolipid biosynthetic enzyme, delta(4)-desaturase, or disrupting ceramide homeostasis with cell-permeable dihydroceramide or ceramide is detrimental to erythroid, but not myeloid, progenitor activity. Coupled with genetic editing-based rewiring of the regulatory circuitry, we demonstrate that ceramide homeostasis commissions vital stem cell factor and erythropoietin signaling by opposing an inhibitory protein phosphatase 2A-dependent, dual-component mechanism. Integrating bioactive lipids as essential components of GATA factor mechanisms to control cell state transitions has implications for diverse cell and tissue types.
Functional iron status of chronic kidney disease patients at the University of Ilorin Teaching Hospital, Ilorin, Nigeria Emmanuel O Sanni, Hannah O Olawumi, Idayat A Durotoye, Timothy O Olanrewaju, Abiola S Babatunde, et al. African Health Sciences, 2022 Background: Functional iron deficiency has been found to be a common cause of poor response to erythropoiesis stimulating agents in anaemic patients with chronic kidney disease (CKD).
 Objectives: Assess the functional iron status of patients with chronic kidney disease.
 Methods: This was a hospital based cross sectional study. The study subjects were chronic kidney disease patients with age and sex matched healthy controls. Full blood count, serum ferritin, soluble transferring receptor, C-reactive protein, serum iron and total iron binding capacity were measured in the patients and healthy controls. Data was analyzed with statistical package for the social sciences software version 22.0. And the level of statistical significance was set at p. value < 0.05.
 Results: The mean ± SD of the age of patient with CKD was 55.0 + 15.4 years, while that of controls was 52.7 + 13.6 years. The mean serum ferritin, serum iron, TIBC and CRP were significantly higher in patients compared with controls (p<0.001, 0.023, <0.001 and 0.001) respectively. Functional iron deficiency was seen in 19.5% of patients with CKD.
 Conclusion: The predominant form of iron deficiency in our study was functional iron deficiency.
 Keywords: Chronic kidney disease; functional iron status; anaemia.
Triglyceride/HDL-cholesterol ratio and plasminogen activator inhibitor-1 independently predict high pulse pressure in sickle cell trait and disease Olatunde P. Olabode, Olawale M. Akinlade, Abiola S. Babatunde, Musbau I. Abdulazeez, Sikiru A. Biliaminu, et al. Archives of Physiology and Biochemistry, 2020 We hypothesised that TG/HDL-C ratio and PAI-1 would be associated with high pulse pressure (PP) in young adults with sickle cell trait (SCT) and sickle cell disease (SCD). We compared the clinical, biochemical, and cardiometabolic parameters among individuals with normal genotype (HbAA; n = 60), SCT (HbAS; n = 60), and SCD (HbSS; n = 60), all in steady state. Using multivariate linear regression analysis, high PP was positively related to TG/HDL-C ratio in SCT (β = 0.307; p = .014) and PAI-1 (β = 0.499; p = .001) in SCD. The curve of receiver operating characteristic also showed that TG/HDL-C ratio and PAI-1 are efficient predictors of high PP in SCT carriers and SCD patients, respectively. This study suggests that increased levels of TG/HDL-C ratio and PAI-1 may be salient risk factors that would promote the development of arterial stiffness and other CVD in SCT carriers and SCD patients.
Polyalthia longifolia Extract Triggers ER Stress in Prostate Cancer Cells Concomitant with Induction of Apoptosis: Insights from in Vitro and in Vivo Studies Saheed O. Afolabi, Olufunke E. Olorundare, Abiola Babatunde, Ralph M. Albrecht, Mamoru Koketsu, et al. Oxidative Medicine and Cellular Longevity, 2019 Plant-based therapies are being explored to prevent or treat several cancer types. The antioxidant properties of Polyalthia longifolia plant are well established. In our previous work, we demonstrated the presence of cytotoxic compounds in the methanol extract of Polyalthia longifolia (MEP) with potent activity against human leukemia cells. In the present study, we evaluated the efficacy of MEP against prostate cancer (PCa) and established the molecular basis of its effect in in vitro and in vivo models. We observed that MEP treatment resulted in a significant decrease in the growth and viability of PCa cells, associated with arrest in the G1/S phase of the cell cycle. Apoptosis was confirmed as the primary mode of MEP-induced cell death through activation of the intrinsic apoptotic machinery. Proteomic and biochemical studies identified BiP as an important target of MEP with the activation of the ER stress pathway, as a potential mechanism driving MEP-induced apoptosis. The extract exhibited strong efficacy in the PCa xenograft mouse model with significant inhibition of tumor growth and reduced tumor burden. Taken together, our findings indicate that MEP-induced apoptosis in PCa cells concomitant with the activation of the ER stress pathways results in the inhibition of tumor growth, in vitro and in vivo. Our studies provide initial evidence of the efficacy of MEP against PCa and advocate for in-depth studies in other preclinical models for its possible use in clinical settings.
Iloneoside: a cytotoxic ditigloylated pregnane glycoside from the leaves of Gongronema latifolium Benth Gideon Ampoma Gyebi, Joseph Oluwatope Adebayo, Olufunke Esan Olorundare, Antoni Pardede, Masayuki Ninomiya, et al. Natural Product Research, 2018 Gongronema latifolium Benth (Asclepiadaceae) is an edible-green-leafy vegetable with known medicinal value. A chemical investigation of the 80% methanolic extract of the leaves led to the isolation of a new pregnane glycoside: iloneoside (3-O-[6-deoxy-3-O-methyl-β-D-allopyranosyl-(1→14)-β-D-oleandropyranosyl]-11,12-di-O-tigloyl-17β-marsdenin), together with four known constituents. Their chemical structures were determined by spectroscopic analysis. The isolates were tested for their in vitro growth inhibitory activity against human leukemia HL-60 cells. Iloneoside was the most active and gave apoptotic response. Molecular docking analysis demonstrated that iloneoside could be accommodated within hot spots of anti-apoptotic protein Bcl-2. These results suggest G. latifolium as a reliable source of potent anticancer compounds.
Fibrinolytic proteins of normal pregnancy and pre-eclamptic patients in North West Nigeria Oluwatosin Oladosu-olayiwola, Hannah Olawumi, Abiola Babatunde, Munirdeen Ijaiya, Idayat Durotoye, et al. African Health Sciences, 2018 Background The hypercoagulability of pregnancy is exaggerated in pre-eclamptic state because of endothelial activation with resultant production of some endothelial derived proteins that are said to be inhibitors of fibrinolysis. This study compares these proteins like tPA, PAI-1 and D-dimers in normal pregnant women and the pre-eclamptic women. Methodology This was a comparative cross-sectional study. Eighty-five pre-eclamptic women were recruited as subjects and eighty five age, trimester and parity matched normotensive pregnant women as controls. Levels of PT, aPTT, tPA, PAI-1, D-dimer protein were determined in blood samples of subjects and controls. Urinalysis was performed with dipstick method on their urine samples. Data generated was analysed using the IBM®SPSS 20.0 (2011) soft ware packages and the level of significance was a p-value <0.05. Results The mean age of the respondents was 29.9±5.2 years. The median(25th–75th percentile) values of D-dimer, tPA, and PAI-1 of subjects were 730 (305.000–1560.000ng/ml), 0.11 (0.065–0,300ng/ml) and 3.65 (2.970–4,400ng/ml) respectively which were significantly higher than the corresponding values in the controls of 520 (24.000–1030.000ng/ml), 0.05 (0.040–0.090ng/ml and 2.650 (2.125–3.400ng/ml) respectively, p<0.05 each. Conclusion The abnormal levels of PAI-1, D-dimer and tPA imply that they contribute to the exaggerated hypercoagulabilty state in pre-eclampsia thus, measuring their levels can help in the management of the condition.
Graviola (Annona muricata) exerts anti-proliferative, anti-clonogenic and pro-apoptotic effects in human non-melanoma skin cancer UW-BCC1 and A431 cells in vitro: Involvement of hedgehog signaling Jean Chamcheu, Islam Rady, Roxane-Cherille Chamcheu, Abu Siddique, Melissa Bloch, et al. International Journal of Molecular Sciences, 2018 Non-melanoma skin cancers (NMSCs) are the leading cause of skin cancer-related morbidity and mortality. Effective strategies are needed to control NMSC occurrence and progression. Non-toxic, plant-derived extracts have been shown to exert multiple anti-cancer effects. Graviola (Annona muricata), a tropical fruit-bearing plant, has been used in traditional medicine against multiple human diseases including cancer. The current study investigated the effects of graviola leaf and stem extract (GLSE) and its solvent-extracted fractions on two human NMSC cell lines, UW-BCC1 and A431. GLSE was found to: (i) dose-dependently suppress UW-BCC1 and A431 cell growth, motility, wound closure, and clonogenicity; (ii) induce G0/G1 cell cycle arrest by downregulating cyclin/cdk factors while upregulating cdk inhibitors, and (iii) induce apoptosis as evidenced by cleavage of caspases-3, -8 and PARP. Further, GLSE suppressed levels of activated hedgehog (Hh) pathway components Smo, Gli 1/2, and Shh while inducing SuFu. GLSE also decreased the expression of pro-apoptotic protein Bax while decreasing the expression of the anti-apoptotic protein Bcl-2. We determined that these activities were concentrated in an acetogenin/alkaloid-rich dichloromethane subfraction of GLSE. Our data identify graviola extracts and their constituents as promising sources for new chemopreventive and therapeutic agent(s) to be further developed for the control of NMSCs.
Short-term effect of oral contraceptive pills on some haemostatic parameters in healthy Nigerian women. Nigerian Postgraduate Medical Journal, 2004
RECENT SCHOLAR PUBLICATIONS
Correction to “Polyalthia longifolia Extract Triggers ER Stress in Prostate Cancer Cells Concomitant with Induction of Apoptosis: Insights from In Vitro and In Vivo Studies” SO Afolabi, OE Olorundare, A Babatunde 2026
Assessment of platelet indices, beta-thromboglobulin and platelet factor IV in platelet concentrate at University of Ilorin Teaching Hospital, Nigeria LO Olatunbosun, MA Muhibi, OT Oke, SA Babatunde, AA Ademosun, ... Scientific Reports 15 (1), 42155 , 2025 2025
Improving Medical Diagnosis with LLM Reprompting BM Amina, PF Ebun, PO Chika, AS Babatunde, M Abdul-Azeez MIRG , 2024 2024
Towards a Multiclass Neural Decision Tree for Large Scale Data Classification AA Ayodeji, PF Ebun, AS Babatunde, M Abdul-Azeez, PO Chika MIRG , 2024 2024
Chitosan-Based Nanoformulated (–)-Epigallocatechin-3-Gallate (EGCG) Modulates Human Keratinocyte-Induced Responses and Alleviates Imiquimod-Induced Murine Psoriasiform … JC Chamcheu, IA Siddiqui, VM Adhami, S Esnault, DJ Bharali, ... International Journal of Nanomedicine 18, 2503-2505 , 2023 2023 Citations: 1
Soil-transmitted helminths infections among fewer than 5 children and associated environmental factors in selected maternal healthcare centres in Ibadan, Nigeria UA Joy, S Babatunde, AO Gbolahan, A Oluwabukola, A Akinyode, ... Am J Pediatr Med Health Sci 1 (3) , 2023 2023 Citations: 2
Prevalence of bacterial pathogens associated to African catfish hatcheries in Akure, Ondo State S Babatunde, A Oluwabukola, AA Oluwasegun, OS Oluwajomiloju, ... Am J Pediatric Med Health Sci 1 (2), 2023 , 2023 2023 Citations: 5
Functional iron status of chronic kidney disease patients at the University of Ilorin Teaching Hospital, Ilorin, Nigeria EO Sanni, HO Olawumi, IA Durotoye, TO Olanrewaju, AS Babatunde, ... African Health Sciences 22 (3), 8 , 2022 2022 Citations: 9
Iloneoside, an antimalarial pregnane glycoside isolated from Gongronema latifolium leaf, potentiates the activity of chloroquine against multidrug resistant Plasmodium falciparum JO Adebayo, IP Ceravolo, GA Gyebi, OE Olorundare, AS Babatunde, ... Molecular and biochemical parasitology 249, 111474 , 2022 2022 Citations: 8
Effects of 3-O-[6-deoxy-3-O-methyl-β-D-allopyranosyl-(1 4)-β-D-canaropyranosyl]-17β-marsdenin on selected indices of cardiovascular diseases in mouse JO Adebayo, AB Orire, GA Gyebi, OE Olorundare, AS Babatunde Comparative Clinical Pathology 31 (1), 155-168 , 2022 2022 Citations: 5
Pattern of haemopoietic progenitor cells differentiation and differentiation enhancing effect of Telfairia occidentalis extract in irradiated guinea-pig LA Olatubosun, EAG Khalil, SA Atunwa, FD Olalere, SA Lawal, ... College of Health Sciences, University of Ilorin , 2021 2021
Determination of normal and variant hemoglobin using capillary electrophoresis among voluntary blood donors in North central Nigeria: implications on blood transfusion services IA Durotoye, AG Salaudeen, EO Sanni, AS Babatunde, AK Durowade, ... Sudan Journal of Medical Sciences 16 (1), 33-42 , 2021 2021 Citations: 3
Current Trend of Transfusion Transmissible Infections among Voluntary Blood Donors in North Central Nigeria IA Durotoye, AG Salaudeen, EO Sanni, KA Durowade, AS Babatunde, ... Tropical Journal of Health Sciences 28 (3), 1-7 , 2021 2021
Beta-Thalassaemia Trait Screening Using Capillary Electrophoresis Among Voluntary Blood Donor in North Central Nigeria IA Durotoye, AG Salaudeen, EO Sanni, AS Babatunde, DK Adekunle, ... Tropical Journal of Health Sciences 28 (1), 9-12 , 2021 2021
In-Vitro Variations in Erythrocyte Ageing Among Different Categoriesof Blood Donors Due to Donor-Related Factors SA Lawal, DO Ugbomoiko, MA Muhibi, LO Olatunbosun, AS Babatunde, ... AL-HIKMAH JOURNAL OF HEALTH SCIENCES (AJOHS) 1 (1) , 2021 2021
Clinico-Pathologic Features and Outcome of Chronic Lymphocytic Leukemia In Ilorin, North Central Nigeria. AS Babatunde, IA Durotoye, AO Shittu, KO Omokanye, MK Ogunfemi, ... Tropical Journal of Health Sciences 27 (2) , 2020 2020
Evaluation of the Indications and diagnostic value of bone marrow examination in haematological disorders in Ilorin Nigeria: A review of 496 cases AS Babatunde, IA Durotoye, AO Shittu, KO Omokanye, MK Ogunfemi, ... The Tropical Journal of Health Sciences 27 (1), 27-33 , 2020 2020 Citations: 1
Operational characteristics and financial performance of African catfish hatcheries under different management systems in Ibadan, Nigeria. O Orisasona, EK Ajani, S Babatunde, BO Omitoyin, EF Osho, OK Kareem African Journal of Food, Agriculture, Nutrition & Development 20 (3), 15709 , 2020 2020 Citations: 2
Triglyceride/HDL-cholesterol ratio and plasminogen activator inhibitor-1 independently predict high pulse pressure in sickle cell trait and disease OP Olabode, OM Akinlade, AS Babatunde, MI Abdulazeez, SA Biliaminu, ... Archives of physiology and biochemistry 126 (2), 166-171 , 2020 2020 Citations: 4
Pattern of Haematological Changes in Patients with Chronic Kidney Disease Attending Nephrology Clinic in a Tertiary Hospital in North Central Nigeria EO Sanni, HO Olawumi, IA Durotoye, AS Babatunde, AO Shittu, ... Journal of Research in Medical and Dental Science 8 (6), 170-175 , 2020 2020 Citations: 2
MOST CITED SCHOLAR PUBLICATIONS
Anticancer Properties of Graviola ( Annona muricata ): A Comprehensive Mechanistic Review I Rady, MB Bloch, RCN Chamcheu, S Banang Mbeumi, MR Anwar, ... Oxidative medicine and cellular longevity 2018 (1), 1826170 , 2018 2018 Citations: 258
Chitosan-based nanoformulated (−)-epigallocatechin-3-gallate (EGCG) modulates human keratinocyte-induced responses and alleviates imiquimod-induced murine psoriasiform dermatitis JC Chamcheu, IA Siddiqui, VM Adhami, S Esnault, DJ Bharali, ... International journal of nanomedicine, 4189-4206 , 2018 2018 Citations: 89
Pattern of haematological malignancies in Ilorin, Nigeria: a ten year review A Babatunde, C Amiwero, P Olatunji, I Durotoye Internet J Hematol 5 (2), 1-7 , 2008 2008 Citations: 55
Graviola ( Annona muricata ) Exerts Anti-Proliferative, Anti-Clonogenic and Pro-Apoptotic Effects in Human Non-Melanoma Skin Cancer UW-BCC1 and A431 Cells … JC Chamcheu, I Rady, RCN Chamcheu, AB Siddique, MB Bloch, ... International journal of molecular sciences 19 (6), 1791 , 2018 2018 Citations: 50
Antimalarial Activity of Cocos nucifera Husk Fibre: Further Studies JO Adebayo, EA Balogun, SO Malomo, AO Soladoye, LA Olatunji, ... Evidence‐Based Complementary and Alternative Medicine 2013 (1), 742476 , 2013 2013 Citations: 34
Impact of Malaria Parasitaemia on Haemitologic Parameters in Pregnant Women at Booking in llorín, Nigeria KT Adesina, OR Balogun, AS Babatunde, MA Sanni, A Fadeyi, A Trends in Medical Research 4 (4), 84-90 , 2009 2009 Citations: 32
Malaria parasitaemia among blood donors in Ilorin, Nigeria HO Olawumi, A Fadeyi, SK Babatunde, AA Akanbi, AS Babatunde, ... African journal of infectious diseases 9 (1), 10 , 2015 2015 Citations: 29
The iron status of sickle cell anaemia patients in Ilorin, North Central Nigeria MA Sani, JO Adewuyi, AS Babatunde, HO Olawumi, RO Shittu Advances in hematology 2015 (1), 386451 , 2015 2015 Citations: 28
Fibrinolytic proteins of normal pregnancy and pre-eclamptic patients in North West Nigeria O Oladosu-Olayiwola, H Olawumi, A Babatunde, M Ijaiya, I Durotoye, ... African Health Sciences 18 (3), 576 , 2018 2018 Citations: 26
Iloneoside: a cytotoxic ditigloylated pregnane glycoside from the leaves of Gongronema latifolium Benth GA Gyebi, JO Adebayo, OE Olorundare, A Pardede, M Ninomiya, ... Natural product research 32 (24), 2882-2886 , 2018 2018 Citations: 23
Bone marrow and peripheral blood cells toxicity of a single 2.0 Gy Cobalt60 ionizing radiation: An animal model S Akeem, O Lukman, K Eltahir, O Fatai, B Abiola, O Khadijat Ethiopian Journal of Health Sciences 29 (2), 195 , 2019 2019 Citations: 21
Normal CD4 count range among healthy Nigerian population in Ilorin JK Afolabi, A Fadeyi, OO Desalu, IA Durotoye, AE Fawibe, MAN Adeboye, ... Journal of the International Association of Providers of AIDS Care (JIAPAC … , 2017 2017 Citations: 20
Polyalthia longifolia Extract Triggers ER Stress in Prostate Cancer Cells Concomitant with Induction of Apoptosis: Insights from In Vitro and In Vivo Studies SO Afolabi, OE Olorundare, A Babatunde, RM Albrecht, M Koketsu, ... Oxidative medicine and cellular longevity 2019 (1), 6726312 , 2019 2019 Citations: 19
Knowledge and perception of sickle cell disease among senior secondary school students in Ilorin metropolis IA Durotoye, AG Salaudeen, AS Babatunde, EC Bosah The tropical Journal of health sciences 20 (2) , 2013 2013 Citations: 18
Haemostatic parameters during pregnancy in Ilorin, Nigeria IA Durotoye, AS Babatunde, HO Olawumi, PO Olatunji, JO Adewuyi Tropical journal of health sciences 19 (2), 18-22 , 2012 2012 Citations: 17
In vivo antimalarial activity and toxicological effects of methanolic extract of Cocos nucifera (Dwarf red variety) husk fibre EA Balogun, SO Malomo, JO Adebayo, AA Ishola, AO Soladoye, ... Journal of Integrative Medicine 12 (6), 504-511 , 2014 2014 Citations: 15
Short-term effect of oral contraceptive pills on some haemostatic parameters in healthy Nigerian women AS Babatunde, PO Olatunji Niger Postgrad Med J 11 (4), 246-250 , 2004 2004 Citations: 15
Risk Determinants to Congenital Malaria in Ilorin, Nigeria OM Kolawole, AS Babatunde, AAG Jimoh, OR Balogun, K I.G Asian Journal of Microbiology, Biotechnology & Enviromental Science 12 (2 … , 2010 2010 Citations: 14
Comparative antileukemic activity of a tetranorditerpene isolated from Polyalthia longifolia leaves and the derivative against human leukemia HL-60 cells S Afolabi, O Olorundare, M Ninomiya, A Babatunde, H Mukhtar, ... Journal of Oleo Science 66 (10), 1169-1174 , 2017 2017 Citations: 12
Functional iron status of chronic kidney disease patients at the University of Ilorin Teaching Hospital, Ilorin, Nigeria EO Sanni, HO Olawumi, IA Durotoye, TO Olanrewaju, AS Babatunde, ... African Health Sciences 22 (3), 8 , 2022 2022 Citations: 9