Abiola Samuel Babatunde

EDUCATION

Madison College, Madison, Wisconsin, USA.
University of Wisconsin-Madison, USA.
Singapore Postgraduate Medical Institute, Singapore General Hospital, Singapore.
National Postgraduate Medical College of Nigeria, Lagos, Nigeria.
University of Port Harcourt, Nigeria

RESEARCH, TEACHING, or OTHER INTERESTS

Hematology, Oncology, Medicine, Cancer Research

Scopus Publications

A transcriptional network governing ceramide homeostasis establishes a cytokine-dependent developmental process
Ruiqi Liao, Abiola Babatunde, Stephanie Qiu, Hamsini Harikumar, Joshua J. Coon, Katherine A. Overmyer, Yusuf A. Hannun, Chiara Luberto, and Emery H. Bresnick
Springer Science and Business Media LLC
AbstractTranscriptional mechanisms controlling developmental processes establish and maintain proteomic networks, which can govern the levels of intracellular small molecules. Although dynamic changes in bioactive small molecules can link transcription factor and genome activity with cell state transitions, many mechanistic questions are unresolved. Using quantitative lipidomics and multiomics, we discover that the hematopoietic transcription factor GATA1 establishes ceramide homeostasis during erythroid differentiation by regulating genes encoding sphingolipid metabolic enzymes. Inhibiting a GATA1-induced sphingolipid biosynthetic enzyme, delta(4)-desaturase, or disrupting ceramide homeostasis with cell-permeable dihydroceramide or ceramide is detrimental to erythroid, but not myeloid, progenitor activity. Coupled with genetic editing-based rewiring of the regulatory circuitry, we demonstrate that ceramide homeostasis commissions vital stem cell factor and erythropoietin signaling by opposing an inhibitory protein phosphatase 2A-dependent, dual-component mechanism. Integrating bioactive lipids as essential components of GATA factor mechanisms to control cell state transitions has implications for diverse cell and tissue types.


Iloneoside, an antimalarial pregnane glycoside isolated from Gongronema latifolium leaf, potentiates the activity of chloroquine against multidrug resistant Plasmodium falciparum
J.O. Adebayo, I.P. Ceravolo, G.A. Gyebi, O.E. Olorundare, A.S. Babatunde, J.P. Penna-Coutinho, M. Koketsu, and A.U. Krettli
Elsevier BV



Effects of 3-O-[6-deoxy-3-O-methyl-β-D-allopyranosyl-(1 4)-β-D-canaropyranosyl]-17β-marsdenin on selected indices of cardiovascular diseases in mouse
Joseph O. Adebayo, A. B. Orire, Gideon A. Gyebi, Olufunke E. Olorundare, and Abiola S. Babatunde
Springer Science and Business Media LLC



Functional iron status of chronic kidney disease patients at the University of Ilorin Teaching Hospital, Ilorin, Nigeria
Emmanuel O Sanni, Hannah O Olawumi, Idayat A Durotoye, Timothy O Olanrewaju, Abiola S Babatunde, Olasunkanmi A Shittu, Sikiru A Biliaminu, Khadijat O Omokanye, Mutiat Kehinde Ogunfemi, Olabisi O Akinwumi,et al.
African Journals Online (AJOL)
Background: Functional iron deficiency has been found to be a common cause of poor response to erythropoiesis stimulating agents in anaemic patients with chronic kidney disease (CKD).
 Objectives: Assess the functional iron status of patients with chronic kidney disease.
 Methods: This was a hospital based cross sectional study. The study subjects were chronic kidney disease patients with age and sex matched healthy controls. Full blood count, serum ferritin, soluble transferring receptor, C-reactive protein, serum iron and total iron binding capacity were measured in the patients and healthy controls. Data was analyzed with statistical package for the social sciences software version 22.0. And the level of statistical significance was set at p. value < 0.05.
 Results: The mean ± SD of the age of patient with CKD was 55.0 + 15.4 years, while that of controls was 52.7 + 13.6 years. The mean serum ferritin, serum iron, TIBC and CRP were significantly higher in patients compared with controls (p<0.001, 0.023, <0.001 and 0.001) respectively. Functional iron deficiency was seen in 19.5% of patients with CKD.
 Conclusion: The predominant form of iron deficiency in our study was functional iron deficiency.
 Keywords: Chronic kidney disease; functional iron status; anaemia.


Triglyceride/HDL-cholesterol ratio and plasminogen activator inhibitor-1 independently predict high pulse pressure in sickle cell trait and disease
Olatunde P. Olabode, Olawale M. Akinlade, Abiola S. Babatunde, Musbau I. Abdulazeez, Sikiru A. Biliaminu, Adewumi O. Oyabambi, Victoria A. Olatunji, Ayodele O. Soladoye, and Lawrence A. Olatunji
Informa UK Limited
Abstract We hypothesised that TG/HDL-C ratio and PAI-1 would be associated with high pulse pressure (PP) in young adults with sickle cell trait (SCT) and sickle cell disease (SCD). We compared the clinical, biochemical, and cardiometabolic parameters among individuals with normal genotype (HbAA; n = 60), SCT (HbAS; n = 60), and SCD (HbSS; n = 60), all in steady state. Using multivariate linear regression analysis, high PP was positively related to TG/HDL-C ratio in SCT (β = 0.307; p = .014) and PAI-1 (β = 0.499; p = .001) in SCD. The curve of receiver operating characteristic also showed that TG/HDL-C ratio and PAI-1 are efficient predictors of high PP in SCT carriers and SCD patients, respectively. This study suggests that increased levels of TG/HDL-C ratio and PAI-1 may be salient risk factors that would promote the development of arterial stiffness and other CVD in SCT carriers and SCD patients.


Polyalthia longifolia Extract Triggers ER Stress in Prostate Cancer Cells Concomitant with Induction of Apoptosis: Insights from in Vitro and in Vivo Studies
Saheed O. Afolabi, Olufunke E. Olorundare, Abiola Babatunde, Ralph M. Albrecht, Mamoru Koketsu, Deeba N. Syed, and Hasan Mukhtar
Hindawi Limited
Plant-based therapies are being explored to prevent or treat several cancer types. The antioxidant properties of Polyalthia longifolia plant are well established. In our previous work, we demonstrated the presence of cytotoxic compounds in the methanol extract of Polyalthia longifolia (MEP) with potent activity against human leukemia cells. In the present study, we evaluated the efficacy of MEP against prostate cancer (PCa) and established the molecular basis of its effect in in vitro and in vivo models. We observed that MEP treatment resulted in a significant decrease in the growth and viability of PCa cells, associated with arrest in the G1/S phase of the cell cycle. Apoptosis was confirmed as the primary mode of MEP-induced cell death through activation of the intrinsic apoptotic machinery. Proteomic and biochemical studies identified BiP as an important target of MEP with the activation of the ER stress pathway, as a potential mechanism driving MEP-induced apoptosis. The extract exhibited strong efficacy in the PCa xenograft mouse model with significant inhibition of tumor growth and reduced tumor burden. Taken together, our findings indicate that MEP-induced apoptosis in PCa cells concomitant with the activation of the ER stress pathways results in the inhibition of tumor growth, in vitro and in vivo. Our studies provide initial evidence of the efficacy of MEP against PCa and advocate for in-depth studies in other preclinical models for its possible use in clinical settings.


Iloneoside: a cytotoxic ditigloylated pregnane glycoside from the leaves of Gongronema latifolium Benth
Gideon Ampoma Gyebi, Joseph Oluwatope Adebayo, Olufunke Esan Olorundare, Antoni Pardede, Masayuki Ninomiya, Afolabi Olanrewaju Saheed, Abiola Samuel Babatunde, and Mamoru Koketsu
Informa UK Limited
Abstract Gongronema latifolium Benth (Asclepiadaceae) is an edible-green-leafy vegetable with known medicinal value. A chemical investigation of the 80% methanolic extract of the leaves led to the isolation of a new pregnane glycoside: iloneoside (3-O-[6-deoxy-3-O-methyl-β-D-allopyranosyl-(1→14)-β-D-oleandropyranosyl]-11,12-di-O-tigloyl-17β-marsdenin), together with four known constituents. Their chemical structures were determined by spectroscopic analysis. The isolates were tested for their in vitro growth inhibitory activity against human leukemia HL-60 cells. Iloneoside was the most active and gave apoptotic response. Molecular docking analysis demonstrated that iloneoside could be accommodated within hot spots of anti-apoptotic protein Bcl-2. These results suggest G. latifolium as a reliable source of potent anticancer compounds.


Fibrinolytic proteins of normal pregnancy and pre-eclamptic patients in North West Nigeria
Oluwatosin Oladosu-olayiwola, Hannah Olawumi, Abiola Babatunde, Munirdeen Ijaiya, Idayat Durotoye, Sikiru Biliaminu, and Rasheedat Ibraheem
African Journals Online (AJOL)
Background The hypercoagulability of pregnancy is exaggerated in pre-eclamptic state because of endothelial activation with resultant production of some endothelial derived proteins that are said to be inhibitors of fibrinolysis. This study compares these proteins like tPA, PAI-1 and D-dimers in normal pregnant women and the pre-eclamptic women. Methodology This was a comparative cross-sectional study. Eighty-five pre-eclamptic women were recruited as subjects and eighty five age, trimester and parity matched normotensive pregnant women as controls. Levels of PT, aPTT, tPA, PAI-1, D-dimer protein were determined in blood samples of subjects and controls. Urinalysis was performed with dipstick method on their urine samples. Data generated was analysed using the IBM®SPSS 20.0 (2011) soft ware packages and the level of significance was a p-value <0.05. Results The mean age of the respondents was 29.9±5.2 years. The median(25th–75th percentile) values of D-dimer, tPA, and PAI-1 of subjects were 730 (305.000–1560.000ng/ml), 0.11 (0.065–0,300ng/ml) and 3.65 (2.970–4,400ng/ml) respectively which were significantly higher than the corresponding values in the controls of 520 (24.000–1030.000ng/ml), 0.05 (0.040–0.090ng/ml and 2.650 (2.125–3.400ng/ml) respectively, p<0.05 each. Conclusion The abnormal levels of PAI-1, D-dimer and tPA imply that they contribute to the exaggerated hypercoagulabilty state in pre-eclampsia thus, measuring their levels can help in the management of the condition.


Graviola (Annona muricata) exerts anti-proliferative, anti-clonogenic and pro-apoptotic effects in human non-melanoma skin cancer UW-BCC1 and A431 cells in vitro: Involvement of hedgehog signaling
Jean Chamcheu, Islam Rady, Roxane-Cherille Chamcheu, Abu Siddique, Melissa Bloch, Sergette Banang Mbeumi, Abiola Babatunde, Mohammad Uddin, Felicite Noubissi, Peter Jurutka,et al.
MDPI AG
Non-melanoma skin cancers (NMSCs) are the leading cause of skin cancer-related morbidity and mortality. Effective strategies are needed to control NMSC occurrence and progression. Non-toxic, plant-derived extracts have been shown to exert multiple anti-cancer effects. Graviola (Annona muricata), a tropical fruit-bearing plant, has been used in traditional medicine against multiple human diseases including cancer. The current study investigated the effects of graviola leaf and stem extract (GLSE) and its solvent-extracted fractions on two human NMSC cell lines, UW-BCC1 and A431. GLSE was found to: (i) dose-dependently suppress UW-BCC1 and A431 cell growth, motility, wound closure, and clonogenicity; (ii) induce G0/G1 cell cycle arrest by downregulating cyclin/cdk factors while upregulating cdk inhibitors, and (iii) induce apoptosis as evidenced by cleavage of caspases-3, -8 and PARP. Further, GLSE suppressed levels of activated hedgehog (Hh) pathway components Smo, Gli 1/2, and Shh while inducing SuFu. GLSE also decreased the expression of pro-apoptotic protein Bax while decreasing the expression of the anti-apoptotic protein Bcl-2. We determined that these activities were concentrated in an acetogenin/alkaloid-rich dichloromethane subfraction of GLSE. Our data identify graviola extracts and their constituents as promising sources for new chemopreventive and therapeutic agent(s) to be further developed for the control of NMSCs.


Neck circumference is independently associated with relative systemic hypertension in young adults with sickle cell anaemia
Lawrence A. Olatunji, Olatunde P. Olabode, Olawale M. Akinlade, Abiola S. Babatunde, Victoria A. Olatunji, and Ayodele O. Soladoye
Springer Science and Business Media LLC



Chitosan-based nanoformulated (-)-epigallocatechin-3-gallate (EGCG) modulates human keratinocyte-induced responses and alleviates imiquimod-induced murine psoriasiform dermatitis
Jean Christopher Chamcheu, Imtiaz A Siddiqui, Vaqar M Adhami, Stephane Esnault, Dhruba J Bharali, Abiola S Babatunde, Stephanie Adame, Randall J Massey, Gary S Wood, B Jack Longley,et al.
Informa UK Limited
Background Psoriasis is a chronic and currently incurable inflammatory skin disease characterized by hyperproliferation, aberrant differentiation, and inflammation, leading to disrupted skin barrier function. The use of natural agents that can abrogate these effects could be useful for the treatment of psoriasis. Earlier studies have shown that treatment of keratinocytes and mouse skin with the green tea polyphenol (−)-epigallocatechin-3-gallate (EGCG) mitigated inflammation and increased the expression of caspase-14 while promoting epidermal differentiation and cornification. However, bioavailability issues have restricted the development of EGCG for the treatment of psoriasis. Materials and methods To overcome these limitations, we employed a chitosan-based polymeric nanoparticle formulation of EGCG (CHI-EGCG-NPs, hereafter termed nanoEGCG) suitable for topical delivery for treating psoriasis. We investigated and compared the efficacy of nanoEGCG versus native or free EGCG in vitro and in an in vivo imiquimod (IMQ)-induced murine psoriasis-like dermatitis model. The in vivo relevance and efficacy of nanoEGCG formulation (48 µg/mouse) were assessed in an IMQ-induced mouse psoriasis-like skin lesion model compared to free EGCG (1 mg/mouse). Results Like free EGCG, nanoEGCG treatment induced differentiation, and decreased proliferation and inflammatory responses in cultured keratinocytes, but with a 4-fold dose advantage. Topically applied nanoEGCG elicited a significant (p<0.01) amelioration of psoriasiform pathological markers in IMQ-induced mouse skin lesions, including reductions in ear and skin thickness, erythema and scales, proliferation (Ki-67), infiltratory immune cells (mast cells, neutrophils, macrophages, and CD4+ T cells), and angiogenesis (CD31). We also observed increases in the protein expression of caspase-14, early (keratin-10) and late (filaggrin and loricrin) markers of differentiation, and the activator protein-1 factor (JunB). Importantly, a significant modulation of several psoriasis-related inflammatory cytokines and chemokines was observed compared to the high dose of free EGCG (p<0.05). Taken together, topically applied nanoEGCG displayed a >20-fold dose advantage over free EGCG. Conclusion Based on these observations, our nanoEGCG formulation represents a promising drug-delivery strategy for treating psoriasis and possibly other inflammatory skin diseases.


Anticancer Properties of Graviola (Annona muricata): A Comprehensive Mechanistic Review
Islam Rady, Melissa B. Bloch, Roxane-Cherille N. Chamcheu, Sergette Banang Mbeumi, Md Rafi Anwar, Hadir Mohamed, Abiola S. Babatunde, Jules-Roger Kuiate, Felicite K. Noubissi, Khalid A. El Sayed,et al.
Hindawi Limited
Graviola (Annona muricata) is a small deciduous tropical evergreen fruit tree, belonging to the Annonaceae family, and is widely grown and distributed in tropical and subtropical regions around the world. The aerial parts of graviola have several functions: the fruits have been widely used as food confectionaries, while several preparations, especially decoctions of the bark, fruits, leaves, pericarp, seeds, and roots, have been extensively used in traditional medicine to treat multiple ailments including cancers by local communities in tropical Africa and South America. The reported therapeutic benefits of graviola against various human tumors and disease agents in in vitro culture and preclinical animal model systems are typically tested for their ability to specifically target the disease, while exerting little or no effect on normal cell viability. Over 212 phytochemical ingredients have been reported in graviola extracts prepared from different plant parts. The specific bioactive constituents responsible for the major anticancer, antioxidant, anti-inflammatory, antimicrobial, and other health benefits of graviola include different classes of annonaceous acetogenins (metabolites and products of the polyketide pathway), alkaloids, flavonoids, sterols, and others. This review summarizes the current understanding of the anticancer effects of A. muricata and its constituents on diverse cancer types and disease states, as well as efficacy and safety concerns. It also includes discussion of our current understanding of possible mechanisms of action, with the hope of further stimulating the development of improved and affordable therapies for a variety of ailments.


A multi-template multiplex PCR assay for hepatitis B virus and human β-globin
Oluwapelumi O. Adeyemi, Morgan R. Herod, Femi Oladiji, Yisa M. Fakunle, Abiola S. Babatunde, and Olajide O. Agbede
Wiley
The Hepatitis B surface antigen (HBsAg) is the hallmark of HBV infection. Detection of antibodies to HBs and the core (ie, HBsAg and HBcAb) are primary serological algorithms in the laboratory diagnosis of HBV. Detection of HBsAg DNA is an important supplement to serological diagnosis especially in clinical cases. Simultaneous amplification of internal cellular controls is a good indicator of sample quality. Human β‐globin is a well characterized housekeeping gene (HKG) that is often applied as internal controls (IC) in molecular diagnosis. In this study, individual plasmid clones of the human β‐globin and HBs genes were constructed. These plasmid constructs have been applied to characterize a multiplex PCR assays for HBs and β‐globin genes. The findings suggest detection limits of less than 10 genome copies of either template In vitro using conventional and multiplex PCR conditions. Under the multiplex conditions, co‐amplification of β‐globin and HBsAg DNA had a resultant effect on assay sensitivity. This study further highlights the importance of molecular diagnosis in HBV infectious individuals. If fully optimized, this assay could provide a possible diagnostic complement to serological detection in developing countries.


Normal CD4 Count Range among Healthy Nigerian Population in Ilorin
J. K. Afolabi, A. Fadeyi, O. O. Desalu, I. A. Durotoye, A. E. Fawibe, M. A. N. Adeboye, H. O. Olawumi, A. S. Babatunde, S. K. Ernest, S. A. Aderibigbe,et al.
SAGE Publications
Background: For the establishment and monitoring of the immune status, CD4 count is critical. Objectives: To determine the CD4 count range of apparently healthy Nigerians resident in Ilorin and compare with the national value. Methods: An automated blood analyzer was used to determine the full blood count and CD4 count. The percentage of CD4 count was derived by using other variables. Results: Of the 1205 participants, the reference CD4 count (percentage of CD4) range for adult was 400 to 1288 cells/mm3 (19%-48%) and for children was 582 to 3652 cells/mm3 (17%-50%). CD4 count and percentage of CD4 were significantly ( P = .001) higher in females than in males, and the CD4 count declined significantly with increasing age ( r = −.174, P ≤ .0001). The percentage of CD4 count shows less variation with age ( r = −.051, P = .076). Adult residents of Ilorin had significantly lower absolute mean CD4 count (808 ± 260) than that of the national reference values of 847.0 ± 307.0 cells/mm3 ( P = .001). Conclusion: We therefore advocate the use of CD4 count range derived in this study is lower than that of the national reference values.


Comparative antileukemic activity of a tetranorditerpene isolated from polyalthia longifolia leaves and the derivative against human leukemia HL-60 cells
Saheed Afolabi, Olufunke Olorundare, Masayuki Ninomiya, Abiola Babatunde, Hasan Mukhtar, and Mamoru Koketsu
Japan Oil Chemists' Society
The discovery of potent cytotoxic isolates from botanicals provides an opportunity to explore this viable tool for cancer chemoprevention. The antileukemic potential of clerodane diterpene from Polyalthia longifolia leaves has already been established. However, in this present study, utilizing chromatographic techniques we report for the first time, the isolation of a rare tetranorditerpene (compound 1) from P. longifolia. The structure of compound 1 was elucidated and confirmed by spectrophotometric data. UPLC-MS analysis was conducted on the methanolic extract, ethyl acetate fraction, and isolated tetranorditerpene showed that the tetranorditerpene is one of the major constituents of the plant with a retention time of 30.78 min. In addition, a methyl ester derivative (compound 2) of the isolated tetranorditerpene was synthesized. Using the CCK-8 assay, we compared the cytotoxic potential of isolated tetranorditerpene (1) and methyl ester derivative (2) with the previously isolated clerodane diterpenes. Our results showed that the methyl ester derivative (2) displayed the highest inhibitory activity against human leukemia HL-60 cells. The isolated tetranorditerpene (1) did not exhibit significant inhibitory effect against HL-60 cells. Morphological examination indicated chromatin condensation and nuclear fragmentation suggesting induction of apoptosis in compound 2 treated HL-60 cells. The methyl esterification of the isolated tetranorditerpene (1) conferred on it a significant level of antileukemic activity suggesting the possibility of a synergistic relationship between pure compound isolation and synthetic reaction in the discovery of new chemopreventive agents.


Clinicopathological features of chronic myeloid leukemia at diagnosis: Study of a series of 46 cases
Shittu Akeem Olasunkanmi, A S Babatunde, and A O Adewoye
Bangladesh Journals Online (JOL)
Introduction: A variety of symptoms and signs are said to be common at diagnosis of chronic myeloid leukemia, but their exact incidence is not well documented. There are conflicting opinions on the incidences of the symptoms and signs.Subjects and methodology: This is a retrospective study whereby the clinical and laboratory features of 46 patients diagnosed as chronic myeloid leukemia at different phases between 1999 and 2009 were retrieved from their case files and analyzed.Results: Of all the patients, 38, 6 and 2 presented in chronic, accelerated and blastic phases respectively. The mean age of the series was 38.3 years (range 17-68 years). The peak age of presentation was 31-40 years (30.48%) followed by 21-30 years (26.1%), 41-50 (21.7%), above 50 years (17.4%) and 10-20 years (4.3%). There was a slight male preponderance 24:22 (1.09:1) with 65% of patients being married and 35% single. Occupation wise, the ratio of petrochemical and benzene related jobs to others was 3:43 (0.07:1). Spleneomegally was the commonest presenting clinical feature in this series and was reported in 44 (95.6%) of our patients. Others were anemia, weight loss, fever, hepatomegally and night sweat.Conclusion: Because of unavailability and unaffordability of the sophisticated diagnostic tools like quantitative PCR in developing worlds, there is need for clinicians to be up to date with the usual and common clinical and laboratory features of chronic myeloid leukemia.Bangladesh Journal of Medical Science Vol.15(1) 2016 p.20-24


Reference values of haematological parameters of healthy adults in the North Central zone of Nigeria




The Iron Status of Sickle Cell Anaemia Patients in Ilorin, North Central Nigeria
Musa A. Sani, James O. Adewuyi, Abiola S. Babatunde, Hannah O. Olawumi, and Rasaki O. Shittu
Hindawi Limited
Objectives. Sickle cell anaemia (SCA) is one of the commonest genetic disorders in the world. It is characterized by anaemia, periodic attacks of thrombotic pain, and chronic systemic organ damage. Recent studies have suggested that individuals with SCA especially from developing countries are more likely to be iron deficient rather than have iron overload. The study aims to determine the iron status of SCA patients in Ilorin, Nigeria.Methods. A cross-sectional study of 45 SCA patients in steady state and 45 non-SCA controls was undertaken. FBC, blood film, sFC, sTfR, and sTfR/log sFC index were done on all subjects.Results. The mean patients’ serum ferritin (589.33 ± 427.61 ng/mL) was significantly higher than the mean serum ferritin of the controls (184.53 ± 119.74 ng/mL). The mean serum transferrin receptor of the patients (4.24 ± 0.17 μg/mL) was higher than that of the controls (3.96 ± 0.17 μg/mL) (p=0.290). The mean serum transferrin receptor (sTfR)/log serum ferritin index of the patients (1.65 ± 0.27 μg/mL) was significantly lower than that of the control (1.82 ± 0.18 μg/mL) (p=0.031).Conclusion. Iron deficiency is uncommon in SCA patients and periodic monitoring of the haematological, biochemical, and clinical features for iron status in SCA patients is advised.


Pattern of childhood malignancies in Ilorin, Nigeria: Challenges and strategies for management in a tertiary health institution
Abiola Samuel Babatunde, Aishatu Ahmed Gobir, Mohammed Akanbi Nurudeen Adeboye, Abdulganiy Adebayo-Oloko, and Idayat Adenike Durotoye
Bangladesh Journals Online (JOL)
Objective: The study was carried out to document the pattern of childhood malignant tumors which were diagnosed at the University of Ilorin Teaching Hospital, Ilorin, and compare with previous reports from other parts of Nigeria and elsewhere and also highlight the challenges and strategies for effective management of these diseases in our environment. Methods: A ten year retrospective analysis of all cancers diagnosed in children below the age of 18 years at the study centre between January 2000 and December 2009 was carried out. Case folders of all children diagnosed with malignant tumors within the study period were retrieved from the Cancer Registry Department of the Hospital and were analyzed with respect to age, gender, morphological or histological type of malignancy, extent of disease, treatment modality, and survival outcome. Results: Ninety nine (99) children were diagnosed with various malignancies during the study period. Sixty seven (67; 67.7%) were boys and 32 (32.3%) were girls giving a male to female ratio of 2:1. There were 22 cases (22.2%) recorded in children aged below 4 years and 72 cases (72.7%) were diagnosed in children between 4-14 years. Lymphomas were the most prevalent malignancies encountered accounting for 54 cases (54.5%), Burkitt’s lymphoma constituted 43 (79.6%) of all lymphoma cases. The distribution of the five foremost malignancies recorded were as follows: Burkitt’s lymphoma (43 cases), Nephroblastoma (10 cases), Retinoblastoma (8 cases), Non Hodgkin’s lymphoma (7 cases) and Acute leukaemias (5 cases). Other malignancies included Osteogenic sarcoma (5), Hodgkin’s lymphoma (4), and 2 cases each of primary liver cell carcinoma, neuroblastoma, rhabdomyosarcoma and nasopharyngeal tumor. Conclusion: The distribution of the various childhood malignant tumors recorded in this study is similar to the pattern reported in previous studies from Nigeria and other countries. However, there appears to be a lower prevalence of leukemia recorded in this study compared to the earlier findings. The challenges which were identified in the diagnosis, management and overall outcome of our patients included limited number of diagnostic tools, late presentation in the hospital, high patient default rate, poverty, and shortage of chemotherapeutic drugs.Bangladesh Journal of Medical Science Vol.14(3) 2015 p.241-246


In vivo antimalarial activity and toxicological effects of methanolic extract of Cocos nucifera (Dwarf red variety) husk fibre
Elizabeth Abidemi Balogun, Sylvia Orume Malomo, Joseph Oluwatope Adebayo, Ahmed Adebayo Ishola, Ayodele Olufemi Soladoye, Lawrence Aderemi Olatunji, Olatunji Matthew Kolawole, Stephen Olubunmi Oguntoye, Abiola Samuel Babatunde, and Oluwole Busayo Akinola
Elsevier BV



Malaria parasitaemia among blood donors in Ilorin, Nigeria
HO Olawumi, A Fadeyi, SK Babatunde, AA Akanbi II, AS Babatunde, MA Sani, and SA Aderibigbe
African Journals Online (AJOL)
BACKGROUND The prevalence of malaria parasitaemia among blood donors in Ilorin has not been documented. In this study, we determined the prevalence of malaria parasitaemia among blood donors in Ilorin, as well as, the sociodemographic and other factors associated with it. METHOD This was a hospital-based cross sectional study involving 308 consenting blood donors. The sociodemographic characteristics of participants as well as blood donation history were obtained using structured questionnaires specifically designed for this purpose. Giemsastained thick and thin blood films to identify malaria parasites were performed using standard method. ABO blood grouping and haemoglobin electrophoresis tests were also done using standard methods. RESULTS The prevalence of malaria parasitaemia among blood donors in Ilorin was 27.3%. The parasite species found were more of Plasmodium falciparum(85.7%) than Plasmodium malariae(14.3%) . There was no age or sex difference in malaria parasitaemia. (p-value of 0.8 and 0.32 respectively). A greater proportion of blood group O individuals had malaria parasitaemia than groups A and B but this difference was not significant (p-value = 0.13). There was also no significant difference among haemoglobin genotypes. CONCLUSION The prevalence of malaria parasites among blood donors in Ilorin is considerably high and lack of routine screening of blood puts recipients at risk. We recommend that routine screening for malaria parasites be commenced in our blood banks. Treatment of donor blood with riboflavin and UV light to inactivate malaria parasites and other infectious pathogens before they are transfused to patients may also be considered in our blood banks.


Antimalarial activity of cocos nucifera husk fibre: Further studies
J. O. Adebayo, E. A. Balogun, S. O. Malomo, A. O. Soladoye, L. A. Olatunji, O. M. Kolawole, O. S. Oguntoye, A. S. Babatunde, O. B. Akinola, A. C. C. Aguiar,et al.
Hindawi Limited
In this study, the antimalarial and toxicity potentials of husk fibre extracts of five Nigerian varieties ofCocos nuciferawere evaluatedin vitro. The only active extract fraction, West African Tall (WAT) ethyl acetate extract fraction, was then evaluated for its phytochemical constituents, antimalarial and toxicity potentials at varying doses (31.25–500 mg/kg body weight) using various organ function indices. The results revealed that WAT ethyl acetate extract fraction (WATEAEF) contained alkaloids, tannins, and flavonoids and was active againstPlasmodium falciparumW2 strain maintained in continuous culture, with a selectivity index of 30.3. The same extract fraction was activein vivoagainstPlasmodium bergheiNK65, causing more than 50% reduction in parasitaemia on days 4 and 6 after inoculation at various doses administered. WATEAEF did not significantly alter (P&gt;0.05) function indices of the liver and cardiovascular system at all doses administered but significantly increased (P&lt;0.05) plasma creatinine concentration at 250 and 500 mg/Kg body weight compared to controls. The results of this study suggest that WATEAEF possesses antimalarial activity and may not adversely affect normal liver function nor predispose subjects to cardiovascular diseases but may impair normal kidney function at higher doses. Further studies are underway to isolate the active principles.


Risk determinants to congenital malaria in Ilorin, Nigeria




Impact of malaria parasitaemia on haematologic parameters in pregnant women at booking in Ilorin, Nigeria
K.T. Adesina, O.R. Balogun, A.S. Babatunde, M.A. Sanni, A. Fadeyi, and S. Aderibigbe
Science Alert



Pattern of haematological malignancies in Ilorin, Nigeria: A ten year review

RECENT SCHOLAR PUBLICATIONS

Improving Medical Diagnosis with LLM Reprompting
BM Amina, PF Ebun, PO Chika, AS Babatunde, M Abdul-Azeez
MIRG 2024



Towards a Multiclass Neural Decision Tree for Large Scale Data Classification
AA Ayodeji, PF Ebun, AS Babatunde, M Abdul-Azeez, PO Chika
MIRG 2024



Chitosan-Based Nanoformulated (–)-Epigallocatechin-3-Gallate (EGCG) Modulates Human Keratinocyte-Induced Responses and Alleviates Imiquimod-Induced Murine Psoriasiform
JC Chamcheu, IA Siddiqui, VM Adhami, S Esnault, DJ Bharali, ...
International Journal of Nanomedicine 18, 2503-2505 2023



Soil-transmitted helminths infections among fewer than 5 children and associated environmental factors in selected maternal healthcare centres in Ibadan, Nigeria
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Am J Pediatr Med Health Sci 1 (3) 2023



Prevalence of bacterial pathogens associated to African catfish hatcheries in Akure, Ondo State
S Babatunde, A Oluwabukola, AA Oluwasegun, OS Oluwajomiloju, ...
Am J Pediatric Med Health Sci 1 (2), 2023 2023



Functional iron status of chronic kidney disease patients at the University of Ilorin Teaching Hospital, Ilorin, Nigeria
EO Sanni, HO Olawumi, IA Durotoye, TO Olanrewaju, AS Babatunde, ...
African Health Sciences 22 (3), 8 2022



Iloneoside, an antimalarial pregnane glycoside isolated from Gongronema latifolium leaf, potentiates the activity of chloroquine against multidrug resistant Plasmodium falciparum
JO Adebayo, IP Ceravolo, GA Gyebi, OE Olorundare, AS Babatunde, ...
Molecular and Biochemical Parasitology 249, 111474 2022



Effects of 3-O-[6-deoxy-3-O-methyl-β-D-allopyranosyl-(1 4)-β-D-canaropyranosyl]-17β-marsdenin on selected indices of cardiovascular diseases in mouse
JO Adebayo, AB Orire, GA Gyebi, OE Olorundare, AS Babatunde
Comparative Clinical Pathology 31 (1), 155-168 2022



Pattern of Haemopoietic Progenitor Cells Differentiation and Differentiation Enhancing Effect of Telfairia occidentalis Extract in Irradiated Guinea-pig.
LO Olatunbosun, EAG Khalil, SA Atunwa, FD Olalere, SA Lawal, ...
EDITORIAL BOARD, 46 2021



Current Trend of Transfusion Transmissible Infections among Voluntary Blood Donors in North Central Nigeria
IA Durotoye, AG Salaudeen, EO Sanni, KA Durowade, AS Babatunde, ...
Tropical Journal of Health Sciences 28 (3), 1-7 2021



Determination of Normal and Variant Hemoglobin using Capillary Electrophoresis among Voluntary Blood Donors in North Central Nigeria: Implications on Blood Transfusion Services
IA Durotoye, AG Salaudeen, EO Sanni, AS Babatunde, AK Durowade, ...
Sudan Journal of Medical Sciences 16 (1), 33-42 2021



Beta-Thalassaemia Trait Screening Using Capillary Electrophoresis Among Voluntary Blood Donor in North Central Nigeria
IA Durotoye, EO Sanni, AG Salaudeen, AS Babatunde, DK Adekunle, ...
Tropical Journal of Health Sciences 28 (1), 9-12 2021



Clinico-Pathologic Features and Outcome of Chronic Lymphocytic Leukemia In Ilorin, North Central Nigeria.
AS Babatunde, IA Durotoye, AO Shittu, KO Omokanye, MK Ogunfemi, ...
Tropical Journal of Health Sciences 27 (2) 2020



Evaluation of the Indications and Diagnostic Value of Bone Marrow Examination in Haematological Disorders in Ilorin Nigeria: A Review of 496 Cases
AS Babatunde, IA Durotoye, AO Shittu, KO Omokanye, MK Ogunfemi, ...
Tropical Journal of Health Sciences 27 (1), 27-33 2020



Operational characteristics and financial performance of african catfish hatcheries under different management systems in Ibadan, Nigeria
O Orisasona, EK Ajani, S Babatunde, BO Omitoyin, EF Osho, OK Kareem
African Journal of Food, Agriculture, Nutrition and Development 20 (3 2020



Triglyceride/HDL-cholesterol ratio and plasminogen activator inhibitor-1 independently predict high pulse pressure in sickle cell trait and disease
OP Olabode, OM Akinlade, AS Babatunde, MI Abdulazeez, SA Biliaminu, ...
Archives of Physiology and Biochemistry 126 (2), 166-171 2020



Pattern of Haematological Changes in Patients with Chronic Kidney Disease Attending Nephrology Clinic in a Tertiary Hospital in North Central Nigeria
EO Sanni, HO Olawumi, IA Durotoye, AS Babatunde, AO Shittu, ...
Journal of Research in Medical and Dental Science 8 (6), 170-175 2020



Determination of Haemoglobin Concentration of Prospective Voluntary Blood Donors using Digital Haemoglobinometer in North Central Nigeria
IA Durotoye, AG Salaudeen, AS Babatunde, KA Durowade, EO Sanni, ...
Journal of Basic and Applied Sciences 11 (1), 18-24 2020



Evaluation of the Clinico-haematological Characteristics and Pattern of Presentation of Acute Myeloid Leukemia in Ilorin, North Central Nigeria.
AS Babatunde, IA Durotoye, AO Shittu, KO Omokanye, MK Ogunfemi, ...
Journal of Basic and Applied Sciences 11 (1), 13-17 2020



Clinico-Laboratory Features of Multiple Myeloma in Selected Patients at University of Ilorin Teaching Hospital, North Central Nigeria
AS Babatunde, IA Durotoye, AO Shittu, KO Omokanye, MK Ogunfemi, ...
University of Ilorin 2019

MOST CITED SCHOLAR PUBLICATIONS

Anticancer Properties of Graviola (Annona muricata): A Comprehensive Mechanistic Review
I Rady, MB Bloch, RCN Chamcheu, S Banang Mbeumi, MR Anwar, ...
Oxidative medicine and cellular longevity 2018 (1), 1826170 2018
Citations: 202



Chitosan-based nanoformulated (−)-epigallocatechin-3-gallate (EGCG) modulates human keratinocyte-induced responses and alleviates imiquimod-induced murine psoriasiform dermatitis
JC Chamcheu, IA Siddiqui, VM Adhami, S Esnault, DJ Bharali, ...
International journal of nanomedicine, 4189-4206 2018
Citations: 73



Pattern of haematological malignancies in Ilorin, Nigeria: a ten year review
A Babatunde, C Amiwero, P Olatunji, I Durotoye
Internet J Hematol 5 (2), 1-7 2009
Citations: 51



Graviola (Annona muricata) Exerts Anti-Proliferative, Anti-Clonogenic and Pro-Apoptotic Effects in Human Non-Melanoma Skin Cancer UW-BCC1 and A431 Cells
JC Chamcheu, I Rady, RCN Chamcheu, AB Siddique, MB Bloch, ...
International journal of molecular sciences 19 (6), 1791 2018
Citations: 43



Antimalarial Activity of Cocos nucifera Husk Fibre: Further Studies
JO Adebayo, EA Balogun, SO Malomo, AO Soladoye, LA Olatunji, ...
Evidence‐Based Complementary and Alternative Medicine 2013 (1), 742476 2013
Citations: 35



Impact of Malaria Parasitaemia on Haemitologic Parameters in Pregnant Women at Booking in llorn, Nigeria
KT Adesina, OR Balogun, AS Babatunde, MA Sanni, A Fadeyi, A
Trends in Medical Research 4 (4), 84-90 2009
Citations: 32



Malaria parasitaemia among blood donors in Ilorin, Nigeria
HO Olawumi, A Fadeyi, SK Babatunde, AA Akanbi II, AS Babatunde, ...
African journal of infectious diseases 9 (1), 10-13 2015
Citations: 27



Fibrinolytic proteins of normal pregnancy and pre-eclamptic patients in North West Nigeria
O Oladosu-Olayiwola, H Olawumi, A Babatunde, M Ijaiya, I Durotoye, ...
African Health Sciences 18 (3), 576-583 2018
Citations: 24



The iron status of sickle cell anaemia patients in ilorin, north central nigeria
MA Sani, JO Adewuyi, AS Babatunde, HO Olawumi, RO Shittu
Advances in hematology 2015 (1), 386451 2015
Citations: 23



Normal CD4 count range among healthy Nigerian population in Ilorin
JK Afolabi, A Fadeyi, OO Desalu, IA Durotoye, AE Fawibe, MAN Adeboye, ...
Journal of the International Association of Providers of AIDS Care (JIAPAC 2017
Citations: 21



Bone marrow and peripheral blood cells toxicity of a single 2.0 Gy Cobalt60 ionizing radiation: An animal model
S Akeem, O Lukman, K Eltahir, O Fatai, B Abiola, O Khadijat
Ethiopian Journal of Health Sciences 29 (2) 2019
Citations: 18



Polyalthia longifolia Extract Triggers ER Stress in Prostate Cancer Cells Concomitant with Induction of Apoptosis: Insights from In Vitro and In Vivo Studies
SO Afolabi, OE Olorundare, A Babatunde, RM Albrecht, M Koketsu, ...
Oxidative medicine and cellular longevity 2019 (1), 6726312 2019
Citations: 16



Iloneoside: a cytotoxic ditigloylated pregnane glycoside from the leaves of Gongronema latifolium Benth
GA Gyebi, JO Adebayo, OE Olorundare, A Pardede, M Ninomiya, ...
Natural product research 32 (24), 2882-2886 2018
Citations: 16



Knowledge and perception of sickle cell disease among senior secondary school students in Ilorin metropolis
IA Durotoye, AG Salaudeen, AS Babatunde, EC Bosah
Tropical Journal of Health Sciences 20 (2) 2013
Citations: 16



Haemostatic parameters during pregnancy in Ilorin, Nigeria
IA Durotoye, AS Babatunde, HO Olawumi, PO Olatunji, JO Adewuyi
Tropical J of Health Sciences 19 (2), 18-22 2012
Citations: 14



Risk Determinants to Congenital Malaria in Ilorin, Nigeria
OM Kolawole, AS Babatunde, AAG Jimoh, OR Balogun, K I.G
Asian Journal of Microbiology, Biotechnology & Enviromental Science 12 (2 2010
Citations: 14



Comparative antileukemic activity of a tetranorditerpene isolated from Polyalthia longifolia leaves and the derivative against human leukemia HL-60 cells
S Afolabi, O Olorundare, M Ninomiya, A Babatunde, H Mukhtar, ...
Journal of Oleo Science 66 (10), 1169-1174 2017
Citations: 12



In vivo antimalarial activity and toxicological effects of methanolic extract of Cocos nucifera (Dwarf red variety) husk fibre
EA Balogun, SO Malomo, JO Adebayo, AA Ishola, AO Soladoye, ...
Journal of Integrative Medicine 12 (6), 504-511 2014
Citations: 12



Short-term effect of oral contraceptive pills on some haemostatic parameters in healthy Nigerian women
AS Babatunde, PO Olatunji
Nigerian Postgraduate Medical Journal 11 (4), 246-250 2004
Citations: 12



Pattern of childhood malignancies in Ilorin, Nigeria: Challenges and strategies for management in a tertiary health institution
AS Babatunde, AA Gobir, MAN Adeboye, A Adebayo-Oloko, IA Durotoye
Bangladesh Journal of Medical Science 14 (3), 241-246 2015
Citations: 6