Ajijolakewu Kamoldeen

@unilorin.edu.ng

Senior Lecturer/Department of Microbiology
University of Ilorin



                       

https://researchid.co/ajijolakewu2

Secondary School at Cardoso High School, Lagos
First Degree (BSc) at the University of Ilorin, Ilorin, Nigeria.
Second Degree (MSc) at the University of Ilorin, Ilorin, Nigeria.
PhD at the Universiti Sains Malaysia

EDUCATION

BSc; MSc and PhD Microbiology

RESEARCH, TEACHING, or OTHER INTERESTS

Biotechnology

16

Scopus Publications

474

Scholar Citations

11

Scholar h-index

12

Scholar i10-index

Scopus Publications


  • Bio-Prospecting Locally Relevant Industrial Yeast Strains from Fermented Carbohydrate-Rich Food Waste from Nigeria
    Mohammed Salih Al-Janaby, Mohammed Q. Al-Ani, and Fadhel M. Lafta
    University of Baghdad College of Science
    Breast cancer is a heterogeneous disease with a significant impact of genes involved in apoptosis. Hence, this study aims to assess the contribution of programmed cell death protein 4(PDCD4) miR-21, miR-449b and PDCD4 genes polymorphism in breast cancer pathogenicity. A total of 180 blood samples were collected from Iraqi women aged between 15-80 years, 120 samples were included from breast cancer patients (divided into two groups of 60 patients under treatment and 60 post treatments and recovery) then 60 healthy women as a control group. The extracted genomic DNA was amplified by PCR technique for the loci of interest and PCR products of the tested samples were genotyped using TaqMan real time fluorescent oligonucleotide for SNPs analysis. PDCD4 protein concentration in serum was estimated utilizing ELISA. The results showed significant association (P = 0.016) of miR-449b rs10061133:A>G polymorphism (AA, AG and GG) on the PDCD4 serum levels (3.62 ng/L, 4.75 ng/L and 2.58 ng/L respectively). PDCD4 serum showed to differ significantly (p = 0.001) among the investigated groups: treatment (5.39  ng/L), post-treatment (3.42ng/L), and control (3.19  ng/L). An evaluation of the effects of breast cancer risk factors on the studied parameter revealed that breastfeeding appears to significantly influence PDCD4 serum levels. Women who breastfed exhibited a mean PDCD4 concentration of 4.40 ng/L, compared to 3.25 ng/L for those who did not breastfeed (P=0.026). Additionally, the AUC value (0.7) suggests that PDCD4 protein could be a good predictive marker for treatment response. Overall, the phenotypic expression of PDCD4 demonstrated to be significantly influenced by polymorphisim of PDCD4, miR-21 and miR-449b SNPs, with a considerable impact of breastfeeding in increasing PDCD4 levels that could be utilized to promote breast cancer prevention strategies.

  • Worldwide Prevalence of Aflatoxins in Food and Feed
    Yusuf Opeyemi Oyebamiji, Kamoldeen Abiodun Ajijolakewu, and Ismail Abiola Adebayo
    Springer International Publishing

  • Profiling of common bacterial pathogens in fish
    Tariq Oluwakunmi Agbabiaka, Ismail Abiola Adebayo, Kamoldeen Abiodun Ajijolakewu, and Toyin Olayemi Agbabiaka
    Elsevier

  • Benefits and limitations of phytoremediation: Heavy metal remediation review
    Azeez Omoniyi Adeoye, Ismail Abiola Adebayo, Adam Moyosore Afodun, and Kamoldeen Abiodun Ajijolakewu
    Elsevier

  • ISOLATION, CHARACTERIZATION and ANTIBACTERIAL SCREENING of ANTIBIOTICS PRODUCED from STREPTOMYCES ISOLATED from DUMPSITE SOILS in ILORIN, NORTH CENTRAL NIGERIA
    Risikat Nike Ahmed, Mercy Oluwaseyi Bamigboye, Kamoldeen Abiodun Ajijolakewu, Sheriffdeen Olakunle Idris, and Nimat Toyosi Ajide Bamigboye
    Univ. of Malaya
    Antibiotics are one of the most exploited metabolites produced by soil actinomycetes. This study isolated fifteen actinomycetes (A1 – A15) from dumpsite soils within Ilorin metropolis & screened them for antibacterial activity. Isolates were identified with morphology & biochemical characteristics.Their activity against clinical bacteria (Escherichia coli, Pseudomonas aeruginosa, Klebsiella pneumoniae & Staphylococcus aureus) was determined. Their bioactive metabolites after fermentation was assayed for by agar well diffusion & compared with reference antibiotics. Molecular analysis of two most active isolates was done. The most active metabolite was subjected to GCMS. All isolates were identified as Streptomyces, 7 isolates exhibited activity against 3 test bacteria with highest (10.5mm±0.35) by Streptomyces griseoplanus while S. aureus demonstrated total resistance to all isolates. Secondary activity revealed 7 of the metabolites as effective against the bacteria with highest activity (28.5±1.04mm) by S. sparsogenes showing similar activity with Cefuroxime (28.01±0.01mm). The two most active isolates were Streptomyces griseoplanus strain NR725RL-ISP 5009 & Streptomyces sparsogenes strain NBRC 1308616S & RNA nucleotide similarity revealed close phylogenic relationship. GC-MS revealed10 compounds in S. sparsogenes strain NBRC 1308616S metabolite. Streptomyces from dumpsite soils within Ilorin produced bioactive compounds against clinical test bacteria and thus could be potential sources of antibiotics.

  • Roles of phytometabolites in the management of obesity
    Azeez Omoniyi Adeoye, Ismail Abiola Adebayo, and Kamoldeen Abiodun Ajijolakewu
    Springer International Publishing

  • Cellulase Production by Co-culture of Bacillus licheniformis and B. paralicheniformis over Monocultures on Microcrystalline Cellulose and Chicken Manure-supplemented Rice Bran Media
    Muinat Olanike Kazeem, Kamoldeen A. Ajijolakewu, and Nor’ Aini Abdul Rahman
    BioResources
    Single cultures and co-cultures of Bacillus licheniformis and Bacillus paralicheniformis isolated from compost were evaluated for their carboxymethyl cellulase (CMCase) and filter paperase (FPase) production potential. Using a medium supplemented with microcrystalline cellulose (MCC), in the co-culture, CMCase and FPase activities increased 8.87- and 2.28-fold and 10.15- and 3.20-fold over B. licheniformis and B. paralicheniformis monocultures, respectively. The synergistic behavior of the two isolates might be due to the consumption of hydrolysis product (glucose, cellobiose) by one or both of the isolates, which improved their metabolic performance for cellulase secretion. Optimal conditions for cellulase production by this co-culture were a temperature of 45 °C, and pH 7 at 180 rpm in a medium containing rice bran at 1% (w/v) and chicken manure as nitrogen supplement at 2% (w/v). The maximum CMCase and FPase produced under the above conditions were 79.8 U/mL and 12.5 U/mL, respectively. This corresponds to 257.4- and 59.5-fold enhancement in CMCase and FPase activity, respectively, over B. licheniformis monoculture, and 306.9- and 83.3-fold increase with respect to the B. paralicheniformis monoculture. These results indicate that improved cellulase production can be achieved through co-culture and chicken manure nitrogen-supplement.

  • Preliminary screening of selected soils in Ilorin, North-central Nigeria for antibiotic-producing actinomycetes
    Risikat N. AHMED, Sesan M. SOBA, Mercy O. BAMIGBOYE, and Kamoldeen A. AJIJOLAKEWU
    Society of Land Measurements and Cadastre from Transylvania
    The present research aimed at screening various soils within Ilorin metropolis for antibiotic producing actinomycetes. The objectives of the study were to determine physiochemical parameters of soils, the occurrence of actinomycetes in soils, antibacterial potentials and identity of isolates. Soil parameters such as pH, temperature, moisture, organic matter and soil type were evaluated following standard procedures. Selective isolation to determine the occurrence of actinomycetes was performed by soil dilution using pour plate technique on starch casein agar. Preliminary antibacterial screening against 10 clinical test bacteria was performed using cross streak method. All isolates were initially identified based on morphological and biochemical characteristics, while the most bioactive isolates were further identified by molecular means. The soils were alkaline, with temperatures between 29 °C and 31 °C, moisture was in range of 0.72 ± 0.07c and 6.62 ± 0.42b. Highest organic matter content was 32.13 ± 0.20a with soil types mostly loamy and sandy loam. Ten actinomycetes (SM1 - SM10) were isolated, with the most frequently occurring isolate being SM3 and SM5 (16.7%). SM5 was the most active, inhibiting 9 out of 10 tests, with the highest inhibition against Staphylococcus aureus 25923 (24 mm ± 0.15a). All isolates were identified as Streptomyces by morphology and biochemical tests. Based on nucleotide similarity searches and phylogeny, two bioactive Streptomycetes were suggested as novel strains and thus named as Streptomyces bottropensis UIL RNA (SM5) and S. flavoviridis UIL RNA(SM7), which may serve as promising sources of antibiotics. Actinomycetes from Ilorin metropolis demonstrated broad spectrum of antibacterial activity against clinical test bacteria.

  • Preparation and Fundamental Characterization of Cellulose Nanocrystal from Oil Palm Fronds Biomass
    Rudi Dungani, Abdulwahab F. Owolabi, Chaturbhuj K. Saurabh, H. P. S. Abdul Khalil, Paridah M. Tahir, C. I. C. M. Hazwan, Kamoldeen A. Ajijolakewu, M. M. Masri, E. Rosamah, and P. Aditiawati
    Springer Science and Business Media LLC



  • Enhanced ethanol production from mild alkali-treated oil-palm empty fruit bunches via co-fermentation of glucose and xylose
    Ajijolakewu A. Kamoldeen, Chee Keong Lee, Wan Nadiah Wan Abdullah, and Cheu Peng Leh
    Elsevier BV

  • Assessment of the effect of easily-metabolised carbon supplements on xylanase production by newly isolated Trichoderma asperellum USM SD4 cultivated on oil palm empty fruit bunches
    Kamoldeen Abiodun Ajijolakewu, Cheu Peng Leh, Wan Nadiah Wan AbduLLah, and Chee Keong Lee
    BioResources
    Effect of lignocellulosic medium supplemented with selected easily-metabolised carbon sources on microbial xylanase production was assessed. A newly isolated oil-palm-waste-domesticated bio-agent-producing fungus, identified based on rRNA analysis as T. asperellum USM SD4 was used as a representative organism. The potential of T. asperellum for enhanced xylanase production was evaluated by the statistical optimization of important cultural parameters via response surface methodology (RSM). T. asperellum showed optimum xylanase activity at pH 7; temperature 27 °C; moisture content 4 mL growth medium (gm): 1 gram dried substrate (gds) and inoculum size 2 x 106 spores/mL. Xylanase activity (2,337 IU/gds) attained in this study was far higher than ever reported for T. asperellum. Using the set of optimum conditions, the mixture of supplementary sugars to the lignocellulosic medium initiated xylanase repression in a concentration-independent manner. However, the degree of repression depended on the nature and type of respectively added sugar. The repressive effect exerted by monosaccharides (xylose, glucose, and fructose) was greater than exerted by either of dimeric (cellobiose and sucrose) or polymeric (xylan) sugars. Of all added substrates, xylan exerted the least repressive effect. Using xylose as a representative sugar, mechanism of xylanase repression was decisively explained and supported with experimental data.

  • Soil screening for antibiotic - Producing microrgansms


  • Bioleaching of lead from Nigerian anglesite ore by Acidithiobacillus ferrooxidans


RECENT SCHOLAR PUBLICATIONS

  • Bio-Prospecting Locally Relevant Industrial Yeast Strains from Fermented Carbohydrate-Rich Food Waste from Nigeria
    MO Kazeem, SO Olabamiji, KA Ajijolakewu, HS Hafid
    Iraqi Journal of Science, 90-102 2025

  • Phytochemical Profiling, GC-MS Analysis and Antibacterial Activity of Sida acuta leave Extracts Against Helicobacter pylori
    K Ajijolakewu, AE Ajadi, SA Ayoola, SI Bale, TA Sorunke, SA Onifade, ...
    UMYU Journal of Microbiology Research (UJMR) 9 (2), 149-158 2024

  • In vitro IN VITRO EVALUATION OF THE ANTIBACTERIAL EFFICACY OF DATURA STRAMONIUM LEAF AGAINST HELICOBACTER PYLORI
    AE Ajadi, AK Ajijolakewu, SA Ayoola, MY Omotunde, BA Aguda
    FUDMA JOURNAL OF SCIENCES 8 (6), 240-247 2024

  • Structural characterization and evaluation of mycogenic zinc oxide nanoparticles from the cell-free culture-extract of Aspergillus niger
    AK Ajijolakewu, MO Kazeem, GM Dovia, IA Adebayo, ...
    Ife Journal of Science 26 (1), 131-143 2024

  • Progress in endophytic fungi secondary metabolites: biosynthetic gene cluster reactivation and advances in metabolomics
    RF Zakariyah, KA Ajijolakewu, AJ Ayodele, BI Folami-A, EP Samuel, ...
    Bulletin of the National Research Centre 48 (1), 44 2024

  • Effects of dietary xylanase-treated rice husk on performance characteristics of West African Dwarf goats Capra hircus
    IO Kolade, MB Yousuf, AY Salako, KA Ajijolakewu, TZ Abdulkareem, ...
    Aceh Journal of Animal Science 9 (1), 18-26 2024

  • Molecular Characterization of Fungi Associated with Pod Rot of the African Locust Beans (Parkia biglobosa)
    AMAO Lateef A. A, Naher L., Abdulkareem M. A, Ajijolakewu K. A
    BIMA JOURNAL OF SCIENCE AND TECHNOLOGY 8 (3B), 260-270 2024

  • Antibacterial Efficacy of Eucalyptus Essential Oil against Respiratory Infection Pathogens and Characterization of its Bioactive Compounds
    AK Abiodun, AR Nike, KM Olanike, OF Olakunle, AZ Mojisola
    Journal of Pharmaceutical Research 23 (1), 62 2024

  • Assessment of the potentials of Azotobacter spp. as bioinoculants on the growth of potted maize plants
    IO Sule, TO Agbabiaka, BK Saliu, KA Ajijolakewu, RF Zakariyah
    Science World Journal 18 (2), 276-282 2023

  • Comparative antibacterial efficacies of the extracts of Enantia chlorantha (Awopa) on selected clinical isolates
    AA Kamoldeen, ABN Toyosi, OM Yetunde, AS Abiodun
    Science World Journal 18 (3), 480-484 2023

  • Effects of Graded Levels of Xylanase-Treated Rice Husk on Nutrient Digestibility and Growth Performance of Broiler Chickens
    I Kolade, M Yousuf, A Salako, K Ajijolakewu, T Abdulkareem, S Lawal
    Malaysian Journal of Applied Sciences 8 (1), 22-31 2023

  • Optımızatıon of Condıtıons for the Productıon of Indole Acetıc Acıd by Azotobacter spp.
    IO Sule, TO Agbabiaka, BK Saliu, KA Ajijolakewu
    UMYU Journal of Microbiology Research 8 (1), 46-53 2023

  • Worldwide prevalence of aflatoxins in food and feed
    YO Oyebamiji, KA Ajijolakewu, IA Adebayo
    Aflatoxins in food: a recent perspective, 41-65 2022

  • phytoremediation: Heavy metal
    AO Adeoye, IA Adebayo, A Moyosore
     2022

  • Profiling of common bacterial pathogens in fish
    TO Agbabiaka, IA Adebayo, KA Ajijolakewu, TO Agbabiaka
    Bacterial Fish Diseases, 229-255 2022

  • Benefits and limitations of phytoremediation: Heavy metal remediation review
    AO Adeoye, IA Adebayo, AM Afodun, KA Ajijolakewu
    Phytoremediation, 227-238 2022

  • Tamarind extract pretreatment: valorization of sugarcane bagasse for cellulase production by aspergillus flavus
    MO Kazeem, KA Ajijolakewu, AMA El-Imam, RB Salau
    Ife Journal of Science 23 (2), 25-34 2021

  • Cellulase production by co-culture of Bacillus licheniformis and B. paralicheniformis over monocultures on microcrystalline cellulose and chicken manure-supplemented rice bran
    M Kazeem, K Ajijolakewu, NA Rahman
    BioResources 16 (4), 6850 2021

  • Isolation, characterization and antibacterial sreening of antibiotics produced from Streptomyces isolated from dumpsite soils in Ilorin, North Central Nigeria
    RN Ahmed, MO Bamigboye, KA Ajijolakewu, SO Idris, NTA Bamigboye
    Malaysian Journal of Science, 1-17 2021

  • Optimization of conditions for xylanase production using Aspergillus tubingensis under different carbon sources
    IO Kolade, MB Yousuf, KA Ajijolakewu, T Agbabiaka, TZ Abdulkareem, ...
    Fountain Journal of Natural and Applied Sciences 10 (1) 2021

MOST CITED SCHOLAR PUBLICATIONS

  • Preparation and fundamental characterization of cellulose nanocrystal from oil palm fronds biomass
    R Dungani, AF Owolabi, CK Saurabh, HPS Abdul Khalil, PM Tahir, ...
    Journal of Polymers and the Environment 25, 692-700 2017
    Citations: 60

  • Enhanced ethanol production from mild alkali-treated oil-palm empty fruit bunches via co-fermentation of glucose and xylose
    AA Kamoldeen, CK Lee, WNW Abdullah, CP Leh
    Renewable Energy 107, 113-123 2017
    Citations: 57

  • Adsorption of cadmium and lead from palm oil mill effluent using bone-composite: Optimisation and isotherm studies
    A Abdulrahman Oyekanmi, AA Abd Latiff, Z Daud, ...
    International Journal of Environmental Analytical Chemistry 99 (8), 707-725 2019
    Citations: 55

  • A review of the ethnomedicinal, antimicrobial, and phytochemical properties of Musa paradisiaca(plantain)
    KA Ajijolakewu, AS Ayoola, TO Agbabiaka, FR Zakariyah, NR Ahmed, ...
    Bulletin of the National Research Centre 45 (1), 86 2021
    Citations: 50

  • Optimization of production conditions for xylanase production by newly isolated strain Aspergillus niger through solid state fermentation of oil palm empty fruit bunches
    AK Ajijolakewu, CP Leh, WNW Abdullah, C keong Lee
    Biocatalysis and Agricultural Biotechnology 11, 239-247 2017
    Citations: 42

  • Characterization of novel Trichoderma hemicellulase and its use to enhance downstream processing of lignocellulosic biomass to simple fermentable sugars
    KA Ajijolakewu, CP Leh, CK Lee, WAW Nadiah
    Biocatalysis and Agricultural Biotechnology 11, 166-175 2017
    Citations: 28

  • Soil screening for antibiotic-producing microrgansms
    AP Microrgansms
    Advances in Environmental Biology 7 (1), 7-11 2013
    Citations: 23

  • Benefits and limitations of phytoremediation: Heavy metal remediation review
    AO Adeoye, IA Adebayo, AM Afodun, KA Ajijolakewu
    Phytoremediation, 227-238 2022
    Citations: 22

  • Assessment of the effect of easily-metabolised carbon supplements on xylanase production by newly isolated Trichoderma asperellum USM SD4 cultivated on oil
    KA Ajijolakewu, LCP Leh CheuPeng, WA Wan Nadiah, ...
     2016
    Citations: 22

  • Comparative antibacterial efficacy of Vitellaria paradoxa (Shea Butter Tree) extracts against some clinical bacterial isolates
    KA AJIJOLAKEWU, FJ AWARUN
    Notulae Scientia Biologicae 7 (3), 264-268 2015
    Citations: 19

  • Antimicrobial effects of Garcinia kola (bitter kola) on some selected pathogens from university of Ilorin teaching hospital Ilorin, Nigeria
    MO Arekemase, AM Babandoko, KRM Ojo, AA Elizabeth, AA Kamoldeen
    Journal of Asian Scientific Research 2 (4), 159 2012
    Citations: 18

  • Cellulase production by co-culture of Bacillus licheniformis and B. paralicheniformis over monocultures on microcrystalline cellulose and chicken manure-supplemented rice bran
    M Kazeem, K Ajijolakewu, NA Rahman
    BioResources 16 (4), 6850 2021
    Citations: 11

  • SCREENING FOR XYLOSYL HYDROLASE (XYLANASE) ENZYMES IN SOIL FUNGAL SPECIES; COMPARATIVE EFFICACY OF SOLID STATE FERMENTATION TECHNIQUE AND PLATE-SCREENING METHODS.
    AK Abiodun, LC Peng, WNW AbduLLah, L Chee
    Exploring the Frontiers in Environmental Science and Technology Research 2015
    Citations: 9

  • Cellulase production potentials of the microbial profile of some sugarcane bagasse dumping sites in Ilorin, Nigeria
    KA AJIJOLAKEWU, S Alhasan, GP OYEYIOLA, RN AHMED, ...
    Notulae Scientia Biologicae 5 (4), 445-449 2013
    Citations: 8

  • Assessment and biological treatment of effluent from a pharmaceutical industry
    GB Adebayo, OM Kolawole, AK Ajijolakewu, SO Abdulrahaman
    Annals of Biological Research 1 (4), 28-33 2010
    Citations: 8

  • Optimisation of Lactic Acid Fermentation from Cassava Peel by Lactobacillus casei (ATCC334)
    RF Zakariyah, MO Ojo, KA Ajijolakewu, KB Saliu, RN Ahmed, ...
    Microbiol. Res. J. Int 31 (6), 29-42 2021
    Citations: 7

  • Bioleaching of lead from Nigerian Anglesite ore by Acidithiobacillus ferrooxidans.
    RN Ahmed, AB Alafara, A Sani, FB Alamu, AK Ajijolakewu
     2012
    Citations: 6

  • Worldwide prevalence of aflatoxins in food and feed
    YO Oyebamiji, KA Ajijolakewu, IA Adebayo
    Aflatoxins in food: a recent perspective, 41-65 2022
    Citations: 5

  • Antibacterial efficacies of extracts of lemon grass (cymbopogon citratus) on some clinical microbial isolates
    K Ajijolakewu, MO Kazeem, RN Ahmed, RF Zakariyah, TO Agbabiaka, ...
    Fountain Journal of Natural and Applied Sciences 10 (1) 2021
    Citations: 4

  • Adansonia digitata (Baobab) fruit pulp as substrate for Bacillus endoglucanase production.
    AD Ibrahim, SI Mukhtar, MN Ibrahim, MA Oke, AK Ajijolakewu
     2012
    Citations: 4