Somasundaram Arumugam

Scopus Publications

Optimized Chitosan–Lecithin Nanocarriers for Nose-to-Brain Delivery of Dalfampridine in Multiple Sclerosis: Box–Behnken Design Optimization, and Toxicity Evaluation
Jaghatha Therassama, Justus Oliver Jaslin Edward, Somasundaram Arumugam, Pavazhaviji Pazhani, Jose Prakash Dharmian
Journal of Pharmaceutical Innovation, 2026
Nanotechnology-driven therapeutic strategies for lambert–eaton myasthenic syndrome: Emerging drug delivery and immunomodulatory approaches
Jaghatha Therassama, Justus Oliver Jaslin Edward, Somasundaram Arumugam, Pavazhaviji Pazhani, Jose Prakash Dharmian
Next Nanotechnology, 2026
New Insights Into the Metabolic Syndrome–Cancer Nexus
Teeshyo Bhattacharya, Shubham Singh Bartwal, Indrajit Bhattacharya, Murali Dhanasekaran, Remya Sreedhar, et al.
Pharmacotherapy Approaches Toward Endocrine and Metabolic Diseases, 2026
Chitosan coated yeast microcapsules for efficient delivery of cefadroxil for the treatment of inflammatory bowel disease
Arab Iram Saba Gaus Mohammed, Victor Hmingthansanga, Pamelika Das, Somasundaram Arumugam, Bhishal Rajdev, et al.
International Journal of Biological Macromolecules, 2026
Insights into decellularized matrix-based therapeutic delivery systems in myocardial infarction
Teeshyo Bhattacharya, Meghoparna Kundu, Pranoti Patil, Indrajit Bhattacharya, Nikitha P. Sibi, et al.
Journal of Drug Delivery Science and Technology, 2026
Anti-Ulcer Effect of Ornithogalum umbellatum at Various Potencies in Indomethacin-Induced Gastric Ulceration in Sprague-Dawley Rats: A Pre-clinical Study
Puja Bhakta, Manoharan Raja, Somasundaram Arumugam, Manoj Limbraj Yellurkar, Vani Sai Prasanna, et al.
Homeopathy, 2026
Gastric ulceration is a major global health issue, and conventional anti-ulcer drugs often cause adverse effects, necessitating safer alternatives. Ornithogalum umbellatum (OrUm), traditionally referenced in homeopathy for gastrointestinal complaints, lacks thorough pre-clinical evaluation. This study investigated the anti-ulcer effects of OrUm in mother tincture (MT), 6C and 30C potencies using an indomethacin-induced gastric ulcer model in Sprague-Dawley rats. Thirty-six rats were divided into six groups (n = 6 per group). Five groups received indomethacin (30 mg/kg, subcutaneously) to induce ulcers. Four of these were treated orally for 7 days with esomeprazole (20 mg/kg), OrUm-MT, OrUm-6C, or OrUm-30C. One group served as disease control and another as normal control. Biochemical parameters (including SGOT, SGPT, ALP, urea, creatinine, glucose, protein), antioxidant markers (MDA, SOD) and histopathological changes were assessed. Liquid chromatography–mass spectrometry (LC–MS) was performed to analyze the phytochemical composition of OrUm-MT. OrUm-6C significantly improved SGOT, SGPT, ALP, urea, glucose, protein and MDA levels (p < 0.05), with histological evidence of mucosal healing. OrUm-MT significantly reduced SGPT and creatinine levels but showed mild ulceration histologically. OrUm-30C showed no significant biochemical improvement. LC-MS analysis of OrUm-MT revealed phenolic acids and flavonoids, which may underlie its antioxidant effects. This is the first pre-clinical study to demonstrate the anti-ulcer potential of OrUm. Among the tested potencies, OrUm-6C showed the most consistent biochemical and histopathological improvements. These findings support further investigation through rigorous pre-clinical and clinical studies to establish its therapeutic potential.
Comparative analysis of the oral and injectable form of heat-inactivated Salmonella Enteritidis vaccine efficacy in commercial chickens
Pooja Barik, Sakil Ahmed, Prakash Biswas, Samiran Mondal, Amrita Sahu, et al.
Microbe Netherlands, 2025
Ellagic acid-imbedded MoO3 nanowires architecture: External mediator-less electrochemical immunoprobing of inflammatory bowel disease marker
Gaurav Rajkumar Pandey, Somasundaram Arumugam, Jayaprakash Thulukanam, Leela Kakithakara Vajravelu, Murugan Veerapandian
Biosensors and Bioelectronics, 2025
Liquid–Liquid Phase Separation: Mechanisms, Roles, and Implications in Cellular Function and Disease
Dikesh Kumar Thakur, Sonal Padole, Tapati Sarkar, Somasundaram Arumugam, Shiladitya Chattopadhyay
FASEB Bioadvances, 2025
Liquid–liquid phase separation is a basic biophysical process that creates essential membraneless organelles that support different cellular activities, including chromatin organization and gene expression. The malfunction of liquid–liquid phase separation (LLPS) plays a critical role in numerous diseases, such as neurodegenerative disorders, including amyotrophic lateral sclerosis (ALS) and Alzheimer's disease (AD), which involve TDP‐43 and Tau, various cancers that utilize SPOP and YAP/TAZ proteins, and viral infections where pathogens use LLPS to replicate and avoid immune detection. This review brings together the fast‐growing knowledge about LLPS across multiple scientific fields. The paper examines the physiological functions of LLPS along with its disease pathogenesis mechanisms and presents various experimental techniques (e.g., advanced microscopy, FRAP, FCS) for its investigation. It introduces new therapeutic approaches such as PTM modulation, small molecules like 1,6‐hexanediol and Lipoamide, and advanced genetic tools including CRISPR and PROTACs like PSETAC, which also explores diagnostic applications. The thorough integration of knowledge presented here is essential to connect separate scientific findings while propelling research forward and turning LLPS discoveries into new biomedical developments.
Beyond obesity: lean metabolic dysfunction-associated steatohepatitis from unveiling molecular pathogenesis to therapeutic advancement
Indrajit Bhattacharya, Deep Kumar Maity, Amit Kumar, Sampriti Sarkar, Teeshyo Bhattacharya, et al.
Naunyn Schmiedeberg S Archives of Pharmacology, 2025
6-Gingerol Protects Against Hypertrophic Cardiomyopathy in High-Fat Diet/Low-Dose Streptozotocin-Induced Diabetic Rats
Research Journal of Pharmacognosy, 2025
Chitosan nanoparticles of rutin mitigated histological changes induced in DNCB-induced colitis by enhanced modulation of inflammation and oxidative stress
Lokesh Nama, Rashmi Bhushan, Prakash Kumar, Somasundaram Arumugam, Om Prakash Ranjan, et al.
Journal of Molecular Histology, 2025
Corrigendum to “Indigenous wisdom of a Kwatha to treat NASH: An insight into the mechanism” [J. Ethnopharmacol. 326 (2024) 117935](S0378874124002344)(10.1016/j.jep.2024.117935)
Manoj Limbraj Yellurkar, Vani Sai Prasanna, Pamelika Das, Sulogna Sarkar, Rakesh Matta, et al.
Journal of Ethnopharmacology, 2025
Novel Polyethyleneimine-chitosan Nanoparticles Encapsulating Urolithin B: A Potential Nanotherapeutic Approach for Diabetic Nephropathy
Jose Prakash Dharmian, S. P. Angelin Claret, Prakash Ramakrishnan, Pavazhaviji Pazhani, Nagamalai Vasimalai, et al.
Journal of Cluster Science, 2025
Rudraksha attenuates right ventricular dysfunction in pulmonary hypertension induced Wistar rats
Pamelika Das, Bhavneesh Kumar, Manoj L. Yellurkar, Vani Sai Prasanna, Sulogna Sarkar, et al.
Pharmacological Research Natural Products, 2025
Editorial: Methods in experimental pharmacology 2023
Somasundaram Arumugam, Amit Khurana, Kala Kumar Bharani
Frontiers in Pharmacology, 2025
Efficiency of phytochemicals to cure metabolic diseases by targeting mitophagy
Teeshyo Bhattacharya, Indrajit Bhattacharya, Devendra Kumar Dhaked, Remya Sreedhar, Somasundaram Arumugam
Plant Based Drug Discovery Unveiling Molecular Targets for Metabolic Conditions, 2025
Zanubrutinib in liquid cancers a new horizon
Amrita Sahu, Rohit Das, Bandana Nath, Teeshyo Bhattacharya, Indrajit Bhattacharya, et al.
Drug Discovery Stories Volume 2, 2025
6-gingerol as an antioxidant to ameliorate kidney injury in high-fat high-fructose diet-induced metabolic syndrome in rats
Endah Wulandari, Salsabila Amanda Putri Andri, Vivian Soetikno, Kusmardi Kusmardi, Melva Louisa, et al.
Journal of Applied Pharmaceutical Science, 2025
ADDITIVE CYTOTOXIC EFFECT OF CISPLATIN AND ANDROGRAPHIS PANICULATA EXTRACT THROUGH THE MODULATION OF APOPTOTIC MARKERS, CYCLIN-D AND VEGF EXPRESSIONS IN SKOV3 OVARIAN CANCER CELL LINE
FARA VITANTRI DIAH, NUZLI FAHDIA MAZFUFAH, WAWAIMULI AROZAL, MELVA LOUISA, SEPTELIA INAWATI WANANDI, et al.
International Journal of Applied Pharmaceutics, 2025
A network pharmacology, molecular docking and in vitro investigation of Picrorhiza kurroa extract for the treatment of diabetic nephropathy
Shiv Pal, Manoj Limbraj Yellurkar, Pamelika Das, Vani Sai Prasanna, Sulogna Sarkar, et al.
Journal of Biomolecular Structure and Dynamics, 2025
Phytocompounds from Indonesia Medicinal Herbs as Potential Apelin Receptor Agonist for Heart Failure Therapy: An In-silico Approach
Muhamad Rizqy Fadhillah, Wawaimuli Arozal, Muhammad Habiburrahman, Somasundaram Arumugam, Heri Wibowo, et al.
International Journal of Technology, 2025
Effect of hydro-ethanolic extract of Abelmoschus moschatus against multidrug resistant uropathogenic Escherichia coli biofilm—An insight into antibiofilm therapeutics
Ambar Bose, Bidhan Chandra Chakraborty, Bhukya Siva, Satheesh Kumar Nanjappan, Somasundaram Arumugam, et al.
South African Journal of Botany, 2024
Arg-Specific serine Protease-Targeted edoxaban tosylate monohydrate-Poly (lactic-co-glycolic acid) Nanoparticles: Investigating Stuart-Prower factor targeting and intestinal distribution through Ex-Vivo fluorescent visualization
Pavazhaviji Pazhani, Jose Prakash Dharmian, Somasundaram Arumugam, Pavithra pazhani, Vijaya Vara Prasad Medapati
European Journal of Pharmaceutics and Biopharmaceutics, 2024
Decellularized extracellular matrix-based bioengineered 3D breast cancer scaffolds for personalized therapy and drug screening
Teeshyo Bhattacharya, Mamta Kumari, Kulwinder Kaur, Santanu Kaity, Somasundaram Arumugam, et al.
Journal of Materials Chemistry B, 2024
Indigenous wisdom of a Kwatha to treat NASH: An insight into the mechanism
Manoj Limbraj Yellurkar, Vani Sai Prasanna, Pamelika Das, Sulogna Sarkar, Rakesh Matta, et al.
Journal of Ethnopharmacology, 2024
Lactic acid-fermented Sake lees protect against nonalcoholic steatohepatitis in mice
Hiroshi Suzuki, Kenichi Watanabe, Somasundaram Arumugam, Rejina Afrin, Masahiko Yamamoto, et al.
Functional Foods in Health and Disease, 2024
Antiviral Activity of Cinchona officinalis, a Homeopathic Medicine, against COVID-19
Somasundaram Arumugam, Kumaravel Vadivel, Devendra Kumar Dhaked, Vani Sai Prasanna, Manoj Limbraj Yellurkar, et al.
Homeopathy, 2024
Anti–intercellular adhesion molecule-1(ICAM-1) nanoparticles for damaged endothelium to treat venous thromboembolism
Pavazhaviji Pazhani, Somasundaram Arumugam, Jose Prakash Dharmian, Vijayavara Prasad Medapatti
Journal of Dispersion Science and Technology, 2024
Edoxaban enfolded beta-1,4-poly-d-glucosamine nanoparticles for targeting eponym Stuart–Prower factor for treatment of venous thrombosis
Pavazhaviji Pazhani, Jose Prakash Dharmian, Somasundaram Arumugam, Pavithra Pazhani, Vijaya Vara Prasad Medapati
Journal of Drug Targeting, 2024
Development of microRNA as prognostic markers in head and neck cancer
Teeshyo Bhattacharya, Shikha Tiwari, Arijit Nandi, Wei-Yu Lin, Somasundaram Arumugam
Diagnostic Prognostic and Therapeutic Role of Micrornas in Head and Neck Cancer, 2024
Paneth-like cells disruption and intestinal dysbiosis in the development of enterocolitis in an iatrogenic rectosigmoid hypoganglionosis rat model
Iskandar Rahardjo Budianto, Kusmardi Kusmardi, Andi Muh. Maulana, Somasundaram Arumugam, Rejina Afrin, et al.
Frontiers in Surgery, 2024
The onset and the development of cardiometabolic aging: an insight into the underlying mechanisms
Sulogna Sarkar, Vani S. Prasanna, Pamelika Das, Hiroshi Suzuki, Kazuya Fujihara, et al.
Frontiers in Pharmacology, 2024
Dual Functional Magnetic Nanoparticles Conjugated with Carbon Quantum Dots for Hyperthermia and Photodynamic Therapy for Cancer
Mounika Choppadandi, Kondi Soumya, Sumanta Ghosh, Aishwarya Balu, Tanvi Shingote, et al.
Nanotheranostics, 2024
Pathophysiology and Management of Onychomycosis and Novel Approaches for Effective Transdermal Applications
International Journal of Pharmaceutical Compounding, 2023
Editorial: Global excellence in ethnopharmacology: Asia
Somasundaram Arumugam, Aiping Lyu, Bey Hing Goh, Uraiwan Panich
Frontiers in Pharmacology, 2023
Hypercoagulability and endothelial activation associated with venous thromboembolism
Pavazhaviji Pazhani, Vijaya VaraPrasad Medapati, Somasundaram Arumugam, Jose Prakash Dharmian
Journal of Applied Pharmaceutical Science, 2023
Potential Targets in Constipation Research: A Review
Ravichandiran Velayutham, Somasundaram Arumugam, Priya Bisht, Neha Dagar, Nitesh Kumar
Current Drug Targets, 2023
Anti-inflammatory interventions to mitigate the cardiovascular risk in metabolic syndrome
Somasundaram Arumugam, Manoj Limbraj Yellurkar, Vani Sai Prasanna, Pamelika Das, Sulogna Sarkar, et al.
Metabolic Syndrome from Mechanisms to Interventions, 2023
Right ventricular failure: a comorbidity or a clinical emergency?
Pamelika Das, Rajarajan A. Thandavarayan, Kenichi Watanabe, Ravichandiran Velayutham, Somasundaram Arumugam
Heart Failure Reviews, 2022
Effect of heat-moisture treated brown rice crackers on postprandial flow-mediated dilation in adults with mild endothelial dysfunction
Kenichi Watanabe, Masao Hirayama, Somasundaram Arumugam, Masayoshi Sugawara, Hisanori Kato, et al.
Heliyon, 2022
Editorial: Anti-Inflammatory Agents in the Context of Age-Related Cardiometabolic Disease: Ethnopharmacological Perspectives
Somasundaram Arumugam, Wawaimuli Arozal, Koji Ikeda
Frontiers in Pharmacology, 2022
Keratinocytes: An Enigmatic Factor in Atopic Dermatitis
Pamelika Das, Pappula Mounika, Manoj Limbraj Yellurkar, Vani Sai Prasanna, Sulogna Sarkar, et al.
Cells, 2022
Current Evidence and Future Perspectives About Herbal Therapeutics for Cancer Therapy
David Paul, A. Parag, K. S. Aswathi, Dinesh Kumar Chellappan, Somasundaram Arumugam, et al.
Handbook of Oxidative Stress in Cancer Therapeutic Aspects Volume 1, 2022
Meal Ingestion of Ceraceomyces tessulatus Strain BDM-X (Agaricomycetes) Protects against Nonalcoholic Steatohepatitis in Mice
Hiroshi Suzuki, Kenichi Watanabe, Somasundaram Arumugam, Manoj Limbraj Yellurkar, Remya Sreedhar, et al.
International Journal of Medicinal Mushrooms, 2022
Evaluation of a natural compound extracted from Dolichandrone atrovirens as a novel antioxidant agent using Caenorhabditis elegans
Manoj Limbraj Yellurkar, Vibhavana Singh, Vani Sai Prasanna, Pamelika Das, Satheeshkumar Nanjappan, et al.
Plos One, 2021
Diabetic nephropathy: A twisted thread to unravel
Neha Dagar, Pamelika Das, Priya Bisht, Amit Kumar Taraphdar, Ravichandiran Velayutham, et al.
Life Sciences, 2021
Le Carbone prevents liver damage in non-alcoholic steatohepatitis-hepatocellular carcinoma mouse model via AMPKα-SIRT1 signaling pathway activation
Mst. Rejina Afrin, Somasundaram Arumugam, Vigneshwaran Pitchaimani, Vengadeshprabhu Karuppagounder, Rajarajan Amirthalingam Thandavarayan, et al.
Heliyon, 2021
Brain adaptations of insulin signaling kinases, GLUT 3, p-BADser155 and nitrotyrosine expression in various hypoglycemic models of mice
Vigneshwaran Pitchaimani, Somasundaram Arumugam, Rajarajan Amirthalingam Thandavarayan, Vengadeshprabhu Karuppagounder, Mst Rejina Afrin, et al.
Neurochemistry International, 2020
3,4-Dihydroxybenzalacetone (DBL) Prevents Aging-Induced Myocardial Changes in Senescence-Accelerated Mouse-Prone 8 (SAMP8) Mice
Vijayasree V. Giridharan, Vengadeshprabhu Karupppagounder, Somasundaram Arumugam, Yutaka Nakamura, Ashrith Guha, et al.
Cells, 2020
Pharmacological investigation of ceraceomyces tessulatus (Agaricomycetes) in mice with nonalcoholic steatohepatitis
Kenichi Watanabe, Rejina Afrin, Remya Sreedhar, Vengadeshprabhu Karuppagounder, Meilei Harima, et al.
International Journal of Medicinal Mushrooms, 2020
Effectiveness of nasal continuous airway pressure therapy in patients with obstructive sleep apnea
Geetha Kandasamy, Dalia Almaghaslah, Palanisamy Sivanandy, Somasundaram Arumugam
International Journal of Health Planning and Management, 2019
Basidiomycetes-X, an edible mushroom, alleviates the development of atopic dermatitis in NC/Nga mouse model
Kenichi Watanabe, Vengadeshprabhu Karuppagounder, Remya Sreedhar, Geetha Kandasamy, Meilei Harima, et al.
Experimental and Molecular Pathology, 2018
Small molecule disruption of G protein βγ subunit signaling reprograms human macrophage phenotype and prevents autoimmune myocarditis in rats
Vengadeshprabhu Karuppagounder, Anamika Bajpai, Shu Meng, Somasundaram Arumugam, Remya Sreedhar, et al.
Plos One, 2018
Comparative evaluation of torasemide and spironolactone on adverse cardiac remodeling in a rat model of dilated cardiomyopathy
Somasundaram Arumugam, Remya Sreedhar, Vengadeshprabhu Karuppagounder, Meilei Harima, Masahiko Nakamura, et al.
Cardiovascular Therapeutics, 2017
Curcumin reduces the risk of chronic kidney damage in mice with nonalcoholic steatohepatitis by modulating endoplasmic reticulum stress and MAPK signaling
Mst. Rejina Afrin, Somasundaram Arumugam, Md. Azizur Rahman, Vengadeshprabhu Karuppagounder, Meilei Harima, et al.
International Immunopharmacology, 2017
Role of 14-3-3η protein on cardiac fatty acid metabolism and macrophage polarization after high fat diet induced type 2 diabetes mellitus
Remya Sreedhar, Somasundaram Arumugam, Rajarajan A. Thandavarayan, Vengadeshprabhu Karuppagounder, Yusuke Koga, et al.
International Journal of Biochemistry and Cell Biology, 2017
The senescence accelerated mouse prone 8 (SAMP8): A novel murine model for cardiac aging
Vengadeshprabhu Karuppagounder, Somasundaram Arumugam, Sahana Suresh Babu, Suresh S. Palaniyandi, Kenichi Watanabe, et al.
Ageing Research Reviews, 2017
Japanese Kampo Medicines for the Treatment of Common Diseases: Focus on Inflammation
Japanese Kampo Medicines for the Treatment of Common Diseases Focus on Inflammation, 2017
General Mechanisms of Immunity and Inflammation
Remya Sreedhar, Kenichi Watanabe, Somasundaram Arumugam
Japanese Kampo Medicines for the Treatment of Common Diseases Focus on Inflammation, 2017
Introduction to Japanese Kampo Medicines
Remya Sreedhar, Kenichi Watanabe, Somasundaram Arumugam
Japanese Kampo Medicines for the Treatment of Common Diseases Focus on Inflammation, 2017
Japanese Kampo Medicine for Hepatic Inflammation
Remya Sreedhar, Geetha Kandasamy, Shanish Antony, Somasundaram Arumugam
Japanese Kampo Medicines for the Treatment of Common Diseases Focus on Inflammation, 2017
Kampo Medicines for Autoimmune Disorders: Rheumatoid Arthritis and Autoimmune Diabetes Mellitus
Kenichi Watanabe, Vengadeshprabhu Karuppagounder, Remya Sreedhar, Meilei Harima, Somasundaram Arumugam
Japanese Kampo Medicines for the Treatment of Common Diseases Focus on Inflammation, 2017
Curcumin ameliorates liver damage and progression of NASH in NASH-HCC mouse model possibly by modulating HMGB1-NF-κB translocation
Rejina Afrin, Somasundaram Arumugam, Azizur Rahman, Mir Imam Ibne Wahed, Vengadeshprabhu Karuppagounder, et al.
International Immunopharmacology, 2017
Comparative effects of torasemide and furosemide on gap junction proteins and cardiac fibrosis in a rat model of dilated cardiomyopathy
Kenichi Watanabe, Remya Sreedhar, Rajarajan A. Thandavarayan, Vengadeshprabhu Karuppagounder, Vijayasree V. Giridharan, et al.
Biofactors, 2017
Tiny molecule, big power: Multi-target approach for curcumin in diabetic cardiomyopathy
Vengadeshprabhu Karuppagounder, Somasundaram Arumugam, Vijayasree V. Giridharan, Remya Sreedhar, Rajendran J.C. Bose, et al.
Nutrition, 2017
Le Carbone, a charcoal supplement, modulates DSS-induced acute colitis in mice through activation of AMPKα and downregulation of STAT3 and caspase 3 dependent apoptotic pathways
Mst. Rejina Afrin, Somasundaram Arumugam, Md. Azizur Rahman, Vengadeshprabhu Karuppagounder, Remya Sreedhar, et al.
International Immunopharmacology, 2017
Fasting time duration modulates the onset of insulin-induced hypoglycemic seizures in mice
Vigneshwaran Pitchaimani, Somasundaram Arumugam, Rajarajan Amirthalingam Thandavarayan, Vengadeshprabhu Karuppagounder, Mst. Rejina Afrin, et al.
Epilepsy Research, 2016
Erratum to “Hypothalamic glucagon signaling in fasting hypoglycemia” (Life Sci. (2016) 153 (118–123))
Vigneshwaran Pitchaimani, Somasundaram Arumugam, Rajarajan Amirthalingam Thandavarayan, Vengadeshprabhu Karuppagounder, Mst. Rejina Afrin, et al.
Life Sciences, 2016
Curcumin alleviates renal dysfunction and suppresses inflammation by shifting from M1 to M2 macrophage polarization in daunorubicin induced nephrotoxicity in rats
Vengadeshprabhu Karuppagounder, Somasundaram Arumugam, Rajarajan A. Thandavarayan, Remya Sreedhar, Vijayasree V. Giridharan, et al.
Cytokine, 2016
Role of MAPK-mediated endoplasmic reticulum stress signaling in the heart during aging in senescence-accelerated prone mice
Remya Sreedhar, Vijayasree V. Giridharan, Somasundaram Arumugam, Vengadeshprabhu Karuppagounder, Suresh S. Palaniyandi, et al.
Biofactors, 2016
Pivotal role of carbohydrate sulfotransferase 15 in fibrosis and mucosal healing in mouse colitis
Kenji Suzuki, Somasundaram Arumugam, Junji Yokoyama, Yusuke Kawauchi, Yutaka Honda, et al.
Plos One, 2016
Targeting fatty acid metabolism in heart failure: Is it a suitable therapeutic approach?
Somasundaram Arumugam, Remya Sreedhar, Rajarajan A. Thandavarayan, Vengadeshprabhu Karuppagounder, Kenichi Watanabe
Drug Discovery Today, 2016
Hypothalamic glucagon signaling in fasting hypoglycemia
Vigneshwaran Pitchaimani, Somasundaram Arumugam, Rajarajan Amirthalingam Thandavarayan, Vengadeshprabhu Karuppagounder, Mst. Rejina Afrin, et al.
Life Sciences, 2016
Curcumin as a therapeutic agent in the chemoprevention of inflammatory bowel disease
Remya Sreedhar, Somasundaram Arumugam, Rajarajan A. Thandavarayan, Vengadeshprabhu Karuppagounder, Kenichi Watanabe
Drug Discovery Today, 2016
Naringenin ameliorates skin inflammation and accelerates phenotypic reprogramming from M1 to M2 macrophage polarization in atopic dermatitis NC/Nga mouse model
Vengadeshprabhu Karuppagounder, Somasundaram Arumugam, Rajarajan Amirthalingam Thandavarayan, Remya Sreedhar, Vijayasree V. Giridharan, et al.
Experimental Dermatology, 2016
Molecular targets of quercetin with anti-inflammatory properties in atopic dermatitis
Vengadeshprabhu Karuppagounder, Somasundaram Arumugam, Rajarajan A. Thandavarayan, Remya Sreedhar, Vijayasree V. Giridharan, et al.
Drug Discovery Today, 2016
Angiotensin receptor blockers: Focus on cardiac and renal injury
Somasundaram Arumugam, Remya Sreedhar, Rajarajan A. Thandavarayan, Vengadeshprabhu Karuppagounder, Prasanna Krishnamurthy, et al.
Trends in Cardiovascular Medicine, 2016
Modulation of Macrophage Polarization and HMGB1-TLR2/TLR4 Cascade Plays a Crucial Role for Cardiac Remodeling in Senescence-Accelerated Prone Mice
Vengadeshprabhu Karuppagounder, Vijayasree V. Giridharan, Somasundaram Arumugam, Remya Sreedhar, Suresh S. Palaniyandi, et al.
Plos One, 2016
Attenuation of Endoplasmic Reticulum Stress-Mediated Liver Damage by Mulberry Leaf Diet in Streptozotocin-Induced Diabetic Rats
Rejina Afrin, Somasundaram Arumugam, Mir Imam Ibne Wahed, Vigneshwaran Pitchaimani, Vengadeshprabhu Karuppagounder, et al.
American Journal of Chinese Medicine, 2016
Depletion of cardiac 14-3-3η protein adversely influences pathologic cardiac remodeling during myocardial infarction after coronary artery ligation in mice
Remya Sreedhar, Somasundaram Arumugam, Rajarajan A. Thandavarayan, Vijayasree V. Giridharan, Vengadeshprabhu Karuppagounder, et al.
International Journal of Cardiology, 2016
Telmisartan treatment targets inflammatory cytokines to suppress the pathogenesis of acute colitis induced by dextran sulphate sodium
Somasundaram Arumugam, Remya Sreedhar, Rajarajan A. Thandavarayan, Vijayasree V. Giridharan, Vengadeshprabhu Karuppagounder, et al.
Cytokine, 2015
Jumihaidokuto effectively inhibits colon inflammation and apoptosis in mice with acute colitis
Remya Sreedhar, Somasundaram Arumugam, Vengadeshprabhu Karuppagounder, Rajarajan A. Thandavarayan, Vijayasree V. Giridharan, et al.
International Immunopharmacology, 2015
Toki-shakuyaku-san, a Japanese kampo medicine, reduces colon inflammation in a mouse model of acute colitis
Remya Sreedhar, Somasundaram Arumugam, Rajarajan A. Thandavarayan, Vijayasree V. Giridharan, Vengadeshprabhu Karuppagounder, et al.
International Immunopharmacology, 2015
Tannic acid modulates NFκB signaling pathway and skin inflammation in NC/Nga mice through PPARγ expression
Vengadeshprabhu Karuppagounder, Somasundaram Arumugam, Rajarajan Amirthalingam Thandavarayan, Vigneshwaran Pitchaimani, Remya Sreedhar, et al.
Cytokine, 2015
Schisandrin B ameliorates ICV-infused amyloid β induced oxidative stress and neuronal dysfunction through inhibiting RAGE/NF-κB/MAPK and Up-regulating HSP/beclin expression
Vijayasree V. Giridharan, Rajarajan A. Thandavarayan, Somasundaram Arumugam, Makoto Mizuno, Hiroyuki Nawa, et al.
Plos One, 2015
Sirtuin-6 deficiency exacerbates diabetes-induced impairment of wound healing
Rajarajan A. Thandavarayan, Venkata Naga Srikanth Garikipati, Darukeshwara Joladarashi, Sahana Suresh Babu, Prince Jeyabal, et al.
Experimental Dermatology, 2015
Small interfering RNA therapy against carbohydrate sulfotransferase 15 inhibits cardiac remodeling in rats with dilated cardiomyopathy
Kenichi Watanabe, Somasundaram Arumugam, Remya Sreedhar, Rajarajan A. Thandavarayan, Takashi Nakamura, et al.
Cellular Signalling, 2015
Naringenin ameliorates daunorubicin induced nephrotoxicity by mitigating AT1R, ERK1/2-NFκB p65 mediated inflammation
Vengadeshprabhu Karuppagounder, Somasundaram Arumugam, Rajarajan Amirthalingam Thandavarayan, Vigneshwaran Pitchaimani, Remya Sreedhar, et al.
International Immunopharmacology, 2015
Effect of carvedilol against myocardial injury due to ischemia-reperfusion of the brain in rats
Meilei Harima, Somasundaram Arumugam, Juan Wen, Vigneshwaran Pitchaimani, Vengadeshprabhu Karuppagounder, et al.
Experimental and Molecular Pathology, 2015
Modulation of HMGB1 translocation and RAGE/NFκB cascade by quercetin treatment mitigates atopic dermatitis in NC/Nga transgenic mice
Vengadeshprabhu Karuppagounder, Somasundaram Arumugam, Rajarajan A. Thandavarayan, Vigneshwaran Pitchaimani, Remya Sreedhar, et al.
Experimental Dermatology, 2015
Pruni cortex ameliorates skin inflammation possibly through HMGB1-NFκB pathway in house dust mite induced atopic dermatitis NC/Nga transgenic mice
Kenichi Watanabe, Vengadeshprabhu Karuppagounder, Somasundaram Arumugam, Rajarajan A. Thandavarayan, Vigneshwaran Pitchaimani, et al.
Journal of Clinical Biochemistry and Nutrition, 2015
Myocardial 14-3-3η protein protects against mitochondria mediated apoptosis
Remya Sreedhar, Somasundaram Arumugam, Rajarajan A. Thandavarayan, Vijayasree V. Giridharan, Vengadeshprabhu Karuppagounder, et al.
Cellular Signalling, 2015
Schisandrin b prevents doxorubicin induced cardiac dysfunction by modulation of DNA damage, oxidative stress and inflammation through inhibition of mapk/p53 signaling
Rajarajan A. Thandavarayan, Vijayasree V. Giridharan, Somasundaram Arumugam, Kenji Suzuki, Kam Ming Ko, et al.
Plos One, 2015
Curcumin ameliorates streptozotocin-induced liver damage through modulation of endoplasmic reticulum stress-mediated apoptosis in diabetic rats
R. Afrin, S. Arumugam, V. Soetikno, R. A. Thandavarayan, V. Pitchaimani, et al.
Free Radical Research, 2015
Fasting mediated increase in p-BADser155 and p-AKTser473 in the prefrontal cortex of mice
Vigneshwaran Pitchaimani, Somasundaram Arumugam, Rajarajan Amirthalingam Thandavarayan, Vengadeshprabhu Karuppagounder, Remya Sreedhar, et al.
Neuroscience Letters, 2014
Olmesartan protects against oxidative stress possibly through the Nrf2 signaling pathway and inhibits inflammation in daunorubicin-induced nephrotoxicity in rats
Vengadeshprabhu Karuppa Gounder, Somasundaram Arumugam, Wawaimuli Arozal, Rajarajan A. Thandavarayan, Vigneshwaran Pitchaimani, et al.
International Immunopharmacology, 2014
Comparative evaluation of torasemide and furosemide on rats with streptozotocin-induced diabetic nephropathy
Somasundaram Arumugam, Remya Sreedhar, Shizuka Miyashita, Vengadeshprabhu Karuppagounder, Rajarajan A. Thandavarayan, et al.
Experimental and Molecular Pathology, 2014
Resveratrol attenuates HMGB1 signaling and inflammation in house dust mite-induced atopic dermatitis in mice
Vengadeshprabhu Karuppagounder, Somasundaram Arumugam, Rajarajan A. Thandavarayan, Vigneshwaran Pitchaimani, Remya Sreedhar, et al.
International Immunopharmacology, 2014
Mulberry leaf diet protects against progression of experimental autoimmune myocarditis to dilated cardiomyopathy via modulation of oxidative stress and MAPK-mediated apoptosis
Somasundaram Arumugam, Sayaka Mito, Rajarajan A. Thandavarayan, Vijayasree V. Giridharan, Vigneshwaran Pitchaimani, et al.
Cardiovascular Therapeutics, 2013
Curcumin alleviates oxidative stress, inflammation, and renal fibrosis in remnant kidney through the Nrf2-keap1 pathway
Vivian Soetikno, Flori R. Sari, Arun P. Lakshmanan, Somasundaram Arumugam, Meilei Harima, et al.
Molecular Nutrition and Food Research, 2013
A murine model for non-alcoholic steatohepatitis showing evidence of association between diabetes and hepatocellular carcinoma
Masato Fujii, Yuichiro Shibazaki, Kyoko Wakamatsu, Yutaka Honda, Yusuke Kawauchi, et al.
Medical Molecular Morphology, 2013
Molecular understanding of curcumin in diabetic nephropathy
Vivian Soetikno, Kenji Suzuki, Punniyakoti T. Veeraveedu, Somasundaram Arumugam, Arun P. Lakshmanan, et al.
Drug Discovery Today, 2013
Mast cells in inflammatory bowel disease: Potential therapeutic targets for intestinal inflammation and fibrosis
Mast Cells Phenotypic Features Biological Functions and Role in Immunity, 2013
Vimentin-positive, profibrogenic mesenchymal cells in intestine: Promising therapeutic targets for intestinal fibrosis
Vimentin Concepts and Molecular Mechanisms, 2013
Diabetic Cardiomyopathy and Oxidative Stress
Somasundaram Arumugam, Vengadeshprabhu Karuppagounder, Rajarajan A. Thandavarayan, Vigneshwaran Pitchaimani, Hirohito Sone, et al.
Diabetes Oxidative Stress and Dietary Antioxidants, 2013
Involvement of AMPK and MAPK signaling during the progression of experimental autoimmune myocarditis in rats and its blockade using a novel antioxidant
Somasundaram Arumugam, Rajarajan A. Thandavarayan, Punniyakoti T. Veeraveedu, Vijayasree V. Giridharan, Vivian Soetikno, et al.
Experimental and Molecular Pathology, 2012
Beneficial effects of edaravone, a novel antioxidant, in rats with dilated cardiomyopathy
Somasundaram Arumugam, Rajarajan A. Thandavarayan, Punniyakoti T. Veeraveedu, Takashi Nakamura, Wawaimuli Arozal, et al.
Journal of Cellular and Molecular Medicine, 2012
Nootropic activity of acetaminophen against colchicine induced cognitive impairment in rats
Vigneshwaran Pitchaimani, Somasundaram Arumugam, Rajarajan A. Thandavarayan, Manisenthilkumar K. Thiyagarajan, Rajasekaran Aiyalu, et al.
Journal of Clinical Biochemistry and Nutrition, 2012
Modulation of endoplasmic reticulum stress and cardiomyocyte apoptosis by mulberry leaf diet in experimental autoimmune myocarditis rats
Somasundaram Arumugam, Rajarajan A. Thandavarayan, Punniyakoti T. Veeraveedu, Meilei Ma, Vijayasree V. Giridharan, et al.
Journal of Clinical Biochemistry and Nutrition, 2012
Quercetin offers cardioprotection against progression of experimental autoimmune myocarditis by suppression of oxidative and endoplasmic reticulum stress via endothelin-1/MAPK signalling
Somasundaram Arumugam, Rajarajan A. Thandavarayan, Wawaimuli Arozal, Flori R. Sari, Vijayasree V. Giridharan, et al.
Free Radical Research, 2012
Candesartan cilexetil protects from cardiac myosin induced cardiotoxicity via reduction of endoplasmic reticulum stress and apoptosis in rats: Involvement of ACE2-Ang (1-7)-mas axis
Somasundaram Arumugam, Rajarajan A. Thandavarayan, Suresh S. Palaniyandi, Vijayasree V. Giridharan, Wawaimuli Arozal, et al.
Toxicology, 2012
Modulation of AT-1R/MAPK cascade by an olmesartan treatment attenuates diabetic nephropathy in streptozotocin-induced diabetic mice
Arun Prasath Lakshmanan, Rajarajan A. Thandavarayan, Kenichi Watanabe, Flori R. Sari, Harima Meilei, et al.
Molecular and Cellular Endocrinology, 2012
Diabetic cardiomyopathy: Role of renin angiotensin system
Angiotensin New Research, 2012
Curcumin attenuates diabetic nephropathy by inhibiting PKC-α and PKC-β1 activity in streptozotocin-induced type I diabetic rats
Vivian Soetikno, Kenichi Watanabe, Flori R. Sari, Meilei Harima, Rajarajan A. Thandavarayan, et al.
Molecular Nutrition and Food Research, 2011
Curcumin attenuates hyperglycaemia-mediated AMPK activation and oxidative stress in cerebrum of streptozotocin-induced diabetic rat
Arun Prasath Lakshmanan, Kenichi Watanabe, Rajarajan A. Thandavarayan, Flori R. Sari, Harima Meilei, et al.
Free Radical Research, 2011
The role of carvedilol in the treatment of dilated and anthracyclines-induced cardiomyopathy
Kenichi Watanabe, Wawaimuli Arozal, Flori R. Sari, Somasundaram Arumugam, Rajarajan A. Thandavarayan, et al.
Pharmaceuticals, 2011
Carvedilol attenuates inflammatory-mediated cardiotoxicity in daunorubicin-induced rats
Flori R. Sari, Wawaimuli Arozal, Kenichi Watanabe, Meilei Harima, Punniyakoti T. Veeravedu, et al.
Pharmaceuticals, 2011
Depletion of 14-3-3 protein exacerbates cardiac oxidative stress, inflammation and remodeling process via modulation of MAPK/NF-κB signaling pathways after streptozotocin-induced diabetes mellitus
Rajarajan A. Thandavarayan, Vijayasree V. Giridharan, Flori R. Sari, Somasundaram Arumugam, Punniyakoti T. Veeraveedu, et al.
Cellular Physiology and Biochemistry, 2011
Regulation of inflammation and myocardial fibrosis in experimental autoimmune myocarditis
Kenichi Watanabe, Vijayakumar Sukumaran, Punniyakoti T. Veeraveedu, Rajarajan A. Thandavarayan, Narasimman Gurusamy, et al.
Inflammation and Allergy Drug Targets, 2011
Evaluation of hepatoprotective activity of Kyllinga nemoralis (Hutch & Dalz) rhizomes
Arumugam Somasundaram, Ramadoss Karthikeyan, Vadivel Velmurugan, Balasubramanian Dhandapani, Muthu Raja
Journal of Ethnopharmacology, 2010
Development and validation of HPTLC method for estimation of quetiapine in bulk drug and in tablet dosage form
International Journal of Pharmtech Research, 2009
Cassia roxburghii seeds protect liver against toxic effects of ethanol and carbontetrachloride in rats
International Journal of Pharmtech Research, 2009
Simultaneous spectrophotometry estimation of nebivolol hydrochloride and hydrochlorothiazide in tablets
Asian Journal of Chemistry, 2008
Xanthine oxidase inhibitory activity of some Indian medical plants
Muthuswamy Umamaheswari, Kuppusamy AsokKumar, Arumugam Somasundaram, Thirumalaisamy Sivashanmugam, Varadharajan Subhadradevi, et al.
Journal of Ethnopharmacology, 2007

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