Surfacehcm

Surfacehcm - Địa điểm uy tín mua bán các sản phẩm công nghệ: Máy tính Microsoft Surface, phụ kiện công nghệ chính hãng, uy tín, giá tốt nhất thị trường, cam kết hàng luôn có sẵn.

Surfacehcm
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RECENT SCHOLAR PUBLICATIONS

The hypertrophic cardiomyopathy myosin variant G256E prolongs cardiac muscle relaxation via altered nucleotide handling
KY Kao, MC Childers, D Pathak, RR Goluguri, TS McMillen, JD Powers, ...
Communications Chemistry , 2026
2026
BPS2026–A FRET assay to monitor different structural states of β-cardiac myosin including the interacting-heads motif
RR Goluguri, P Guhathakurta, N Nandwani, A Dawood, S Yokota, ...
Biophysical Journal 125 (4), 8a , 2026
2026
BPS2026–Exploring the dynamics of β-cardiac myosin auto-inhibited state to predict the development of inherited cardiomyopathies
D Auguin, L Lannes, CM Kikuti, M Juillé, N Ayoub, K Ruppel, JA Spudich, ...
Biophysical Journal 125 (4), 38a , 2026
2026
BPS2026–The hypertrophic cardiomyopathy mutation G768R makes cardiac myosin a high duty ratio motor
D Pathak, TN Ozturk, MC Childers, M Regnier, C Liu, JA Spudich, ...
Biophysical Journal 125 (4), 90a , 2026
2026
BPS2026–The G256E HCM mutation prolongs relaxation via altered nucleotide handling
KY Kao, MC Childers, D Pathak, RR Goluguri, TS McMillen, KM Ruppel, ...
Biophysical Journal 125 (4), 90a , 2026
2026
The G256E HCM mutation prolongs cardiac muscle relaxation via altered nucleotide handling
M Regnier, K Kao, M Childers, D Pathak, RR Goluguri, T McMillen, ...
2025
Hypertrophic cardiomyopathy mutations Y115H and E497D disrupt the folded-back state of human β-cardiac myosin allosterically
N Nandwani, D Bhowmik, C Glaser, MC Childers, RR Goluguri, ...
Nature Communications 16 (1), 8751 , 2025
2025
Citations: 15
A FRET assay to monitor different structural states of human β-cardiac myosin including the interacting-heads motif
RR Goluguri, P Guhathakurta, N Nandwani, A Dawood, S Yokota, ...
Proceedings of the National Academy of Sciences 122 (34), e2504562122 , 2025
2025
Citations: 9
Michael Patrick Sheetz, 1946–2025, a devotee of and major contributor to membrane and cytoskeletal biology
LJ Kenney, RD Vale, JA Spudich
Molecular biology of the cell 36 (8), fe1 , 2025
2025
Structure of the thin filament in human iPSC-derived cardiomyocytes and its response to heart disease
RA Woldeyes, M Nishiga, AS Vander Roest, L Engel, P Giri, ...
bioRxiv, 2023.10. 26.564098 , 2025
2025
Citations: 4
BPS2025-Functional assessment of recombinant human alpha-cardiac myosin and the effect of atrial arrhythmia mutations
AD Pawar, SC Yokota, JA Spudich, K Ruppel, M Kawana
Biophysical Journal 124 (3), 615a , 2025
2025
Citations: 1
BPS2025-Multiscale approach and atomic resolution insights for the dysregulation leading to cardiomyopathies
AM Houdusse, L Lannes, D Auguin, CM Kikuti, M Juille, N Nandwani, ...
Biophysical Journal 124 (3), 298a , 2025
2025
Citations: 1
A FRET assay to quantitate levels of the human β-cardiac myosin interacting heads motif based on its near-atomic resolution structure
RR Goluguri, P Guhathakurta, N Nandwani, A Dawood, S Yakota, ...
bioRxiv , 2024
2024
Citations: 2
From amoeboid myosin to unique targeted medicines for a genetic cardiac disease
JA Spudich
Frontiers in Physiology 15, 1496569 , 2024
2024
Citations: 6
Reassessing the unifying hypothesis for hypercontractility caused by myosin mutations in hypertrophic cardiomyopathy
JA Spudich, N Nandwani, J Robert-Paganin, A Houdusse, KM Ruppel
The EMBO Journal 43 (19), 4139 , 2024
2024
Citations: 31
One must reconstitute the functions of interest from purified proteins
JA Spudich
Frontiers in Physiology 15, 1390186 , 2024
2024
Citations: 5
Incomplete-penetrant hypertrophic cardiomyopathy MYH7 G256E mutation causes hypercontractility and elevated mitochondrial respiration
S Lee, AS Vander Roest, CA Blair, K Kao, SB Bremner, MC Childers, ...
Proceedings of the National Academy of Sciences 121 (19), e2318413121 , 2024
2024
Citations: 22
Broad therapeutic benefit of myosin inhibition in hypertrophic cardiomyopathy
L Sen-Martín, Á Fernández-Trasancos, MÁ López-Unzu, D Pathak, ...
bioRxiv, 2024.03. 22.584986 , 2024
2024
Citations: 4
Homologous mutations in human β, embryonic, and perinatal muscle myosins have divergent effects on molecular power generation
C Liu, A Karabina, A Meller, A Bhattacharjee, CJ Agostino, GR Bowman, ...
Proceedings of the National Academy of Sciences 121 (9), e2315472121 , 2024
2024
Citations: 6
Motility assay to Probe the calcium sensitivity of myosin and regulated thin filaments
C Liu, KM Ruppel, JA Spudich
Familial Cardiomyopathies: Methods and Protocols, 169-189 , 2023
2023
Citations: 2

MOST CITED SCHOLAR PUBLICATIONS

The regulation of rabbit skeletal muscle contraction: I. Biochemical studies of the interaction of the tropomyosin-troponin complex with actin and the proteolytic fragments of …
JA Spudich, S Watt
Journal of biological chemistry 246 (15), 4866-4871 , 1971
1971
Citations: 5653
Single myosin molecule mechanics: piconewton forces and nanometre steps
JT Finer, RM Simmons, JA Spudich
nature 368 (6467), 113-119 , 1994
1994
Citations: 2576
Disruption of the Dictyostelium Myosin Heavy Chain Gene by Homologous Recombination
A De Lozanne, JA Spudich
Science 236 (4805), 1086-1091 , 1987
1987
Citations: 1237
Fluorescent actin filaments move on myosin fixed to a glass surface.
SJ Kron, JA Spudich
Proceedings of the National Academy of Sciences 83 (17), 6272-6276 , 1986
1986
Citations: 1178
Optimized localization analysis for single-molecule tracking and super-resolution microscopy
KI Mortensen, LS Churchman, JA Spudich, H Flyvbjerg
Nature methods 7 (5), 377-381 , 2010
2010
Citations: 1155
Myosin-V is a processive actin-based motor
AD Mehta, RS Rock, M Rief, JA Spudich, MS Mooseker, RE Cheney
Nature 400 (6744), 590-593 , 1999
1999
Citations: 1022
Single-molecule biomechanics with optical methods
AD Mehta, M Rief, JA Spudich, DA Smith, RM Simmons
Science 283 (5408), 1689-1695 , 1999
1999
Citations: 954
A small-molecule inhibitor of sarcomere contractility suppresses hypertrophic cardiomyopathy in mice
EM Green, H Wakimoto, RL Anderson, MJ Evanchik, JM Gorham, ...
Science 351 (6273), 617-621 , 2016
2016
Citations: 851
Quantitative measurements of force and displacement using an optical trap
RM Simmons, JT Finer, S Chu, JA Spudich
Biophysical journal 70 (4), 1813-1822 , 1996
1996
Citations: 751
Myosin structure and function in cell motility
HM Warrick, JA Spudich
Annual review of cell biology 3 (1), 379-421 , 1987
1987
Citations: 668
Nonmuscle contractile proteins: the role of actin and myosin in cell motility and shape determination
M Clarke, JA Spudich
Annual review of biochemistry 46 (1), 797-822 , 1977
1977
Citations: 668
Myosin subfragment-1 is sufficient to move actin filaments in vitro
YY Toyoshima, SJ Kron, EM McNally, KR Niebling, C Toyoshima, ...
Nature 328 (6130), 536-539 , 1987
1987
Citations: 667
Movement of myosin-coated fluorescent beads on actin cables in vitro
MP Sheetz, JA Spudich
Nature 303 (5912), 31-35 , 1983
1983
Citations: 620
The neck region of the myosin motor domain acts as a lever arm to generate movement.
TQ Uyeda, PD Abramson, JA Spudich
Proceedings of the National Academy of Sciences 93 (9), 4459-4464 , 1996
1996
Citations: 609
How molecular motors work
JA Spudich
Nature 372 (6506), 515-518 , 1994
1994
Citations: 608
Myosin step size: estimation from slow sliding movement of actin over low densities of heavy meromyosin
TQP Uyeda, SJ Kron, JA Spudich
Journal of molecular biology 214 (3), 699-710 , 1990
1990
Citations: 591
Myosin-V stepping kinetics: a molecular model for processivity
M Rief, RS Rock, AD Mehta, MS Mooseker, RE Cheney, JA Spudich
Proceedings of the National Academy of Sciences 97 (17), 9482-9486 , 2000
2000
Citations: 519
[33] Assays for actin sliding movement over myosin-coated surfaces
SJ Kron, YY Toyoshima, TQP Uyeda, JA Spudich
Methods in enzymology 196, 399-416 , 1991
1991
Citations: 517
Cytoskeletal elements of chick embryo fibroblasts revealed by detergent extraction
S Brown, W Levinson, JA Spudich
Journal of supramolecular structure 5 (2), 119-130 , 1976
1976
Citations: 491
Myosin VI is a processive motor with a large step size
RS Rock, SE Rice, AL Wells, TJ Purcell, JA Spudich, HL Sweeney
Proceedings of the National Academy of Sciences 98 (24), 13655-13659 , 2001
2001
Citations: 480