Akorede Ganiu Jimoh

EDUCATION

DVM, MSc.

RESEARCH, TEACHING, or OTHER INTERESTS

Pharmacology, Toxicology and Pharmaceutics, Small Animals, Developmental Biology, General Veterinary

Scopus Publications

Co-administration of Hibiscus sabdariffa linn and Daflon-500® mitigates weight loss, hyperglycemia, hematological and oxidative changes in male rats with type-2 diabetes
Aishat Omobolanle Olatunji, Root Oluwapelumi Alegbe, Suleiman Folorunsho Ambali, Muftau Shittu, Ganiu Jimoh Akorede, Abdulfatai Aremu, Afisu Basiru, Jamila Abdulhamid Atata, Kolawole Yusuf Suleiman, and Charles Amoto Shuaibu
Elsevier BV



Ameliorative potentials of diosmin and hesperidin fractions on chlorpyriphos-induced changes in reproductive hormones, sperm characteristics, and testicular glycogen in male Wistar rats
Aishat Omobolanle Olatunji, Joseph Olusegun Ayo, Mohammed Musa Suleiman, Suleiman Folorunsho Ambali, Muftau Shittu, Ganiu Jimoh Akorede, Abdulfatai Aremu, Ibrahim Yusuf Lamidi, Basiru Afisu, and Olubukola Tolulope Adenubi
Springer Science and Business Media LLC



Vitamin C Protects Against Blood and Thyroid Toxicities Induced by the Chronic Use of Carbamazepine in Rats
Ganiu Jimoh Akorede, , Suleiman Folorunsho Ambali, Aisha Omobolanle Olatunji, Abdulfatai Aremu, Akeem Olayiwola Ahmed, Afisu Basiru, Mistura Oyebisi Azeez, Fatima Sanusi, Rafiu Adebisi Kadir,et al.
Negah Scientific Publisher
Background: Drugs are the mainstay of the clinical management of epilepsy. Carbamazepine (CBZ) is commonly used for treating epilepsy and neuropathic pain. This drug has been reported to have toxic effects on the hematological system due to its induction of oxidative stress. This study aimed to investigate the protective effects of vitamin C against hematological and thyroid toxicities caused by the chronic use of carbamazepine in male Wistar rats. Methods: Thirty-two adult Wistar rats were categorized randomly into four groups of eight rats each and treated as follows: Group 1 received distilled water (2 mL/kg); group 2 was treated with vitamin C (100 mg/kg); group 3 received carbamazepine (20 mg/kg), and group 4 was pre-treated with vitamin C (100 mg/kg) and given carbamazepine (20 mg/kg) 30 min later. All treatments were administered via gavage once per day over fifteen consecutive weeks. The rats’ blood samples were tested for changes in hematological parameters while the sera were evaluated for liver biochemical enzymes and thyroid hormone levels. Results: The results revealed that pre-treatment with vitamin C protected against alterations in parameters associated with hematological and thyroid toxicities. Conclusion: Based on the study results, it was concluded that: a) The chronic use of CBZ caused hematological and thyroid toxicities, and b) Vitamin C protected against these toxicities. Therefore, it is highly likely that vitamin C has the potential to protect experimental animals against injuries induced by CBZ to the liver, blood cells, and hypothalamic-pituitary-thyroid axis in a Wistar rat model.


Diagnosis of Toxic Stress Induced Pseudomonas aeruginosa Infection in Juvenile Clarias gariepinus; Not as Easy as it Seems
Akeem O. Ahmed et al.
Egypts Presidential Specialized Council for Education and Scientific Research
ABSTRACT


Antimicrobial profiles of Salmonella species isolated from ruminants slaughtered at the two major abattoirs in Ilorin, Nigeria
Philip Babatunde, Akeem Ahmed, Mahmoud Shuaib, Mashood Raji, Abdulfatai Aremu, Ganiu Akorede, Abdulwahab Sulyman, Ahmadu Umaru, and Ibrahim Raufu
Egypts Presidential Specialized Council for Education and Scientific Research
Background: worldwide activities in the countries. The present study was carried out to determine the isolation rate and antimicrobial susceptibility profiles of Salmonella species from ruminants slaughtered for human consumption at the two major abattoirs in Ilorin, Kwara State. Methods : Between November, 2019 and February, 2020, a total 500 samples were collected from the two major abattoirs in Ilorin metropolis (cattle, n = 240; goat, n = 260). Salmonella species were isolated and identified using standard bacteriological techniques. The isolates were subjected antimicrobial susceptibility test using Kirby Bauer disk diffusion assay. Results : 20 (4 %) Salmonella isolates were obtained, there was no significant statistical difference between the isolation rates from cattle (3.75 %) and the small ruminant (4.23 %). Varying degree of resistance patterns were obtained with high proportion of the isolates (> 60 %) displaying resistance to penicillin and cephalosporin tested while low resistant phenotypes (5 %) were observed against quinolones. The isolates were pan-susceptible to gentamicin. Conclusion : The study documented multidrug resistant Salmonella isolates from ruminants slaughtered for human consumption. It is recommended that further studies to characterize the isolates will assist in recommending the appropriate control strategies to prevent the transmission of resistant Salmonella strains to human via food chain.


Effect of daflon-500^®, a flavonoid compound on chlorpyriphos-induced oxidative changes in the hypophysis and testes in adult male rats
Aishat O. Olatunji, Joseph O. Ayo, Mohammed M. Suleiman, Suleiman F. Ambali, Muftau Shittu, Ganiu J. Akorede, Lukman O. Raji, Jamila A. Atata, Khalid T. Biobaku, and Mistura O. Azeez
Springer Science and Business Media LLC



Mitigative potentials of methanol leaf extract of Moringa oleifera on chronic carbamazepine-induced haemo-biochemical and thyrotoxicity in male Wistar rats
Ganiu Jimoh Akorede, Suleiman Folorunsho Ambali, Aisha Omobolanle Olatunji, Abdulfatai Aremu, Afisu Basiru, Akeem Olayiwola Ahmed, Mistura Olabisi Azeez, Isiaku Abdulmajeed, and Rafiu Adebisi Kadir
Elsevier BV



Effect of heat stress on vital and hematobiochemical parameters of healthy dogs
Oyebisi Mistura Azeez, Folashade Helen Olaifa, Adakole Sylvanus Adah, Afisu Basiru, Ganiu Jimoh Akorede, Hauwa Moturayo Ambali, Kolawole Yusuf Suleiman, Fatima Sanusi, and Mashood Bolaji
Veterinary World
Background and Aim: Heat stress is a major challenge for animals, impairing their welfare and performance. This study aimed to determine the effect of heat stress on the vital and hematobiochemical parameters of healthy dogs. Materials and Methods: The experimental subjects comprised 10 dogs, encompassing seven males and three non-pregnant females between 2 and 3 years of age. Ambient temperature (AT) and relative humidity (RH) were recorded 2 hourly during the day and the temperature humidity index was calculated. Vital parameters [i.e., rectal temperature (RT), respiratory rate, and heart rate (HR)] were assessed and blood was collected from each dog daily for hematobiochemical analysis. Results: The RT (38.5±0.2°C) of dogs exposed to high AT and high RH (HA/HR) conditions was significantly (p<0.05) higher than that of dogs exposed to HA and low RH (LR) conditions (37.2±0.11°C). Under HA/HR conditions, packed cell volume, hemoglobin concentrations, and white blood cell counts were significantly lower than those of the same dogs exposed to HA/LR conditions. Conversely, under HA/HR conditions, the lymphocyte, monocyte, eosinophil, alanine aminotransferase, aspartate aminotransferase, and cortisol values were significantly higher (p<0.05) than the values obtained in dogs exposed to HA/LR conditions. Meanwhile, the alkaline phosphatase, urea, and glucose levels were significantly lower (p<0.05) in dogs exposed to HA/HR conditions. Conclusion: The exposure of healthy dogs to HA/HR conditions induced heat stress, which may have an adverse effect on their immune status, thereby affecting their health and welfare.


Carbamazepine evoked reproductive toxicity in male Wistar rats: protective properties of Moringa oleifera leaves methanolic extract
Ganiu Jimoh Akorede, Suleiman Folorunsho Ambali, Mikail Garba Hudu, Mohammed M. Suleiman, Kolawole Yusuf Suleiman, Halimat Amin Abdulrahim, Lukman Oladimeji Raji, and Isiaku AbdulMajeed
Springer Science and Business Media LLC



Salmonella enterica isolated from selected poultry farms in Kwara State, Nigeria between 2015 and 2016 showed resistance to critical antimicrobials
Akeem Ahmed, Moshood Raji, Paul Mamman, Clara Kwanashie, Ibrahim Raufu, Ganiu Akorede, Abdulfatai Aremu, Khalid Biobaku, and Yusuf Suleiman
Journal of Central European Agriculture
Salmonellosis is a major public health hazard globally. This study was designed to determine the antimicrobial resistance among Salmonella serovars isolated from selected poultry farms in Kwara State, Nigeria between 2015 and 2016 using a cross sectional approach. A total of 58 Salmonella isolates were serotyped, 13 different serovars were identified and subjected to antibiotic susceptibility test using disc diffusion method. All the isolates (100.0%) exhibited resistance to at least one antimicrobial agent. All of the isolates exhibited 100% resistance to ampicillin, 65.5% of the isolates showed resistance to cefotaxime while 63.8% of the isolates were resistant to either of ciprofloxacin and nalidixic acid. Low level of resistance was observed for neomycin (22.4%) compare to other antimicrobials. S. enterica ser. 4, 12, 27: z: - exhibited resistance to all antimicrobial agents. Considering the types of samples that were positive for Salmonella across different local government areas, frequencies of resistance were statistically significant only to gentamicin (P=0.016) in Ilorin west local government area, only nalidixic acid (P =0.014) in Irepodun local government area, only compound sulfonamide (P=0.002) in Asa local government area and streptomycin (P=0.025) in Ilorin-South local government area. The results indicated the relatively high resistance to the antimicrobial agents tested and the multi-drug-resistance among the Salmonella serovars. These observations pose therapeutic concerns on poultry farms in the study area and may serve as potential sources of multi- drug-resistant Salmonella transmission to the humans.


Protective effect of vitamin C on chronic carbamazepine-induced reproductive toxicity in male wistar rats
Ganiu Jimoh Akorede, Suleiman Folorusho Ambali, Mikai’l Garba Hudu, Aisha Omobolanle Olatunji, Muftau Shittu, Abdulfatai Aremu, Afisu Basiru, Khalid Talha Biobaku, Akeem Olayiwola Ahmed, and Saliu Akanni Ameen
Elsevier BV



Adverse reproductive effects of ethanolic root extract of Waltheria indica in male Wistar rats
Afisu Basiru, Ganiu Jimoh Akorede, Kehinde Soetan, and Funsho O. Olayemi
Walter de Gruyter GmbH
Abstract Background Numerous uses of Waltheria indica plant such as antitrypanosomal, antibacterial and antimalarial effects have been reported. It has however been reported that most plants with antibacterial and antiprotozoal effects have adverse effect on male reproduction. Hence, we evaluated the effect of Waltheria indica root on male reproductive parameters. Methods Twenty adult male Wistar rats were randomly divided into four groups (n=5); A–D. Group A served as control group while groups B, C and D were administered with 200, 400 and 800 mg/Kg body weight of crude ethanolic extract of Waltheria indica root. After 28 days of administration, the rats were sacrificed and sperm parameters, sperm morphology, serum reproductive hormones and lipids were determined. Results There was a significant reduction in sperm count and motility as well as significant increase in percentage abnormal sperm cell (p<0.001) at the 400 and 800 mg/kg BW. The serum levels of testosterone was also significantly reduced while total cholesterol increased significantly (p<0.05) at the highest dose. Conclusion Waltheria indica root has adverse effect on male reproduction through reduction in sperm parameters and male reproductive hormones.


Salmonellosis: Serotypes, prevalence and multi-drug resistant profiles of Salmonella enterica in selected poultry farms, Kwara State, North Central Nigeria
Akeem O. Ahmed, Moshood A. Raji, Paul H. Mamman, Clara N. Kwanashie, Ibrahim A. Raufu, Abdulfatai Aremu, and Ganiu J. Akorede
AOSIS
Salmonellosis is a major threat facing the poultry industry globally. This study was conducted to investigate the level of Salmonella contaminations and determine the resistance pattern of isolates obtained from selected poultry farms in Kwara State, a transition state between southern and northern regions of Nigeria. A total of 900 samples were collected between January and August 2017, from the poultry environment, apparently including healthy and dead birds. Salmonella was isolated and identified using standard bacteriological methods. All presumptive Salmonella isolates were serotyped and tested for antimicrobial susceptibility using 11 different antimicrobials. A total of 58 (6.4%) Salmonella isolates were obtained, and the isolation rate was only statistically significant (p < 0.05) in live birds. The isolates comprised of 13 serovars. The three predominant serovars, Salmonella enterica ser. 6.7:d:- (29.0%), Salmonella Agama (28.0%) and Salmonella Typhimurium (16.0%), were isolated from all three sample types. Rare serovars like Salmonella Albany, Salmonella Colindale, Salmonella Istanbul, Salmonella Larochelle, Salmonella Nigeria and Salmonella Orion were also isolated in this study. A high frequency of resistance was generally observed with all the isolates exhibiting a total of (100%) resistance to ampicillin, cefotaxime and ceftazidime. This study documents the first predominant isolation of S. enterica ser. 6.7:d:- and S. Agama from chickens. It also documents the high frequency of fluoroquinolone and cephalosporins resistance of the isolates indicating the presence of selective pressure in the environment. Controls and targeted interventions against Salmonella and the frequent occurrence of antimicrobial resistance in chickens should be initiated to prevent the spread of this organism.


Serotypes, antimicrobial profiles, and public health significance of Salmonella from camels slaughtered in Maiduguri central abattoir, Nigeria
Ibrahim A. Raufu, Ismail A. Odetokun, Fatai S. Oladunni, Mohammed Adam, Ubaidat T. Kolapo, Ganiu J. Akorede, Ibraheem M. Ghali, James A. Ameh, and Abdulganiyu Ambali
Veterinary World
Aim: This study aimed at determining the serotypes, antimicrobial profiles, and public health importance of Salmonella strains from camels slaughtered at Maiduguri central abattoir, Nigeria. Materials and Methods: Two hundred samples were obtained from camel comprising of intestines, feces, liver, and spleen (n=50 each). Non-lactose fermenting dark center Salmonella colonies were identified using standard biochemical techniques, serotyped and subjected to antimicrobial susceptibility test using minimum inhibition concentration method. Results: Out of the 200 samples collected, 17 were Salmonella positive (spleen=7, intestine=6, feces=3, and liver=1) with a prevalence of 8.5%. Five serotypes comprising Salmonella Eko, 7 (3.5%), Salmonella Uganda, 4 (2.0%), Salmonella Amager, 2 (1.0%), Salmonella Westhampton, 2 (1.0%), and Salmonella Give, 2 (1.0%) were incriminated. Majority of the serotypes were sensitive to the antimicrobials, but one Salmonella Amager exhibited resistance to streptomycin, and one each of Salmonella Uganda and Salmonella Eko were resistant to sulfamethoxazole. Conclusion: This study revealed the prevalence and the antibiotic resistance profile of newly emerging Salmonella from camels in the northeast of Nigeria, which can serve as a means for the transmission of Salmonella to human. Therefore, there is a need for the establishment of national Salmonella surveillance and control programs.

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