Postdoctoral Fellow in Dr. Itakura’s (Beckman Research Institute at City of Hope, CA, USA, 1984-1988) and Dr. Caruthers’s (University of Colorado at Boulder, USA, 1988-1989) laboratories. Postdoctoral fellow, University of Barcelona, 1989-1990. Group Leader at CSIC, Barcelona, 1990-1994. Group Leader and responsible of DNA synthesis facility at EMBL, Heidelberg, Germany, 1994-1999. Research Professor at IBMB-CSIC leading the Nucleic Acid Chemistry Group since 1999. Invited member of the IRB Barcelona (2006-2012). Selected as member of the Networking Center on Bioengennering, Biomaterials and Nanomedicine of Spain (CIBER-BBN) since 2006. Director of institute (IQAC, 2012-2017). Expertise on oligonucleotide and peptide synthesis especially on the methodological aspects of solid-phase synthesis (monomer synthesis, preparation of solid supports, synthesis and purification). Experience in most areas related to the synthesis and properties of oligonucleotide derivatives.
EDUCATION
B. Sc. Chemistry, University of Barcelona, 1977. B. Sc. Pharmacy, University of Barcelona 1982. Ph.D. Chemistry, University of Barcelona, 1983.
RESEARCH, TEACHING, or OTHER INTERESTS
Organic Chemistry, Drug Discovery, Biochemistry, Genetics and Molecular Biology, Structural Biology
Enhanced muscle uptake of chemically optimized miR-23b antisense oligonucleotides as lead compounds for myotonic dystrophy type 1 Irene González-Martínez, Estefanía Cerro-Herreros, Marc Carrascosa-Sàez, Andrea García-Rey, Diego Piqueras-Losilla, Anna Colom-Rodrigo, Nerea Moreno, Mouli Chakraborty, Aline Huguet-Lachon, Anchel González-Barriga, Neia Naldaiz-Gastesi, Martxel Dehesa, Ana Díaz-Maqueda, Nuria Barquero, Miguel A. Varela, Adolfo López de Munain, Ramon Eritja, Geneviève Gourdon, Arturo López-Castel, Manuel Pérez-Alonso, Beatriz Llamusi, Rubén Artero American Journal of Human Genetics, 2026 and DMSXL mice and human myoblasts), increasing MBNL1 levels, correcting mis-splicing, improving muscle strength, and reducing myotonia. They also exhibited efficient biodistribution to skeletal muscle, a critical DM1-affected tissue. In vitro toxicology indicated a favorable safety profile with minimal immune or renal toxicity. The antimiR mechanism was conserved in rat and pig fibroblasts. Overall, two lead antimiRs emerged as promising therapeutic candidates for DM1, with improved pharmacokinetics, tissue targeting, and safety, supporting the potential of microRNA-based approaches to correct key molecular defects in this disorder.
Conjugation strategy shapes antitumor efficacy and enables dose-sparing in non-antibody protein nanoconjugates Ariana Rueda, Annabel Garcia-Leon, Lourdes A. Arena, Julian I. Mendoza, Anna Aviñó, Carme Fabrega, Ramon Eritja, David Paez, Lorena Alba-Castellon, Esther Vazquez, Antonio Villaverde, Ramon Mangues, Isolda Casanova, Ugutz Unzueta Materials Today Bio, 2026 Precision targeting is a hot topic in cancer nanomedicine, as conventional chemotherapies cause systemic toxicities, creating an urgent need for more selective treatments. Although antibody-drug conjugates (ADCs) are the current gold standard in targeted therapy, their clinical performance remains limited. As an alternative, we previously developed a multivalent protein nanocarrier (T22-GFP-H6) displaying the CXCR4-targeting peptide T22, which offers super-selective tumor accumulation driven by CXCR4 overexpression. This innovative nanovehicle showed favorable biodistribution for targeted delivery of antitumor drugs, including monomethyl auristatin E (MMAE), in a first-generation stochastic nanoconjugate format. However, unlike ADCs, where conjugation strategy is known to influence pharmacokinetics and efficacy, these parameters remain largely unexplored in non-antibody multivalent nanocarriers. Here, we evaluated the impact of precise payload accommodation using two site-specific strategies that attach a single MMAE molecule at distinct structural sites, and we compared them with first-generation nanoconjugates. The conjugation strategy substantially affected the biodistribution and antitumor efficacy, with a solvent-exposed cysteine-conjugation distal to the targeting ligand proving most effective. At equimolar nanocarrier dosing, this construct achieved tumor control similar to the stochastic conjugate in a disseminated hematologic malignancy despite an approximately 4-fold lower MMAE load (drug-to-protein ratio, DPR = 1 vs DPR ≈ 4). Moreover, at equimolar MMAE dosing, it clearly outperformed both the stochastic conjugate and the alternative site-directed design. These findings align with trends in advanced ADCs and provide practical design rules for rational, site-specific conjugation in next-generation protein-based nanomedicines aimed at enabling dose-sparing in oncology.
G-quadruplexes as therapeutic platforms for anticancer drug delivery: from intrinsic cytotoxicity to drug delivery and nanotechnology Arnau Domínguez, Natalia Navarro, Anna Aviñó, Carme Fàbrega, Ramon Eritja Expert Opinion on Drug Delivery, 2026 INTRODUCTION: G-quadruplexes have emerged as a versatile class of oligonucleotides that combine molecular recognition, intrinsic anticancer activity and drug carrier functions, offering new opportunities to improve tumor selectivity and overcome limitations of conventional chemotherapy. AREAS COVERED: This review summarizes structural and biological features that make G-quadruplexes attractive platforms for anticancer drug delivery, including cancer-selective uptake, high stability and scaffold versatility. We discuss G-quadruplexes with intrinsic antiproliferative activity, covalent G-quadruplex-drug conjugates including small molecules and nucleoside antimetabolites and G-quadruplexes that non-covalently host G-quadruplex ligands. We further examine G-quadruplex-decorated nanoparticles and DNA nanostructures, as well as, higher-order G-quadruplex architectures that enable multivalent receptor targeting. A literature search was conducted using the Web of Science database to identify peer-reviewed publications related to 'G-quadruplex.' The search covered the period from 2000 to the present (as of 12 January 2026). EXPERT OPINION: G-quadruplexes represent a platform with unique capacity to unify targeting and therapy, offering a promising alternative to antibody-based systems. However, issues such as structural polymorphism, pharmacokinetics, and controlled drug release must be addressed through rational design and chemical modification to fully translate these delivery systems into clinically relevant anticancer therapeutics.
Enhanced i-Motif Stability through Consecutive 2′,2′-Difluorocytidine Incorporation Arnau Domínguez, Cristina Cabrero, Irene Gómez‐Pinto, Carme Fàbrega, Raimundo Gargallo, Ramon Eritja, Carlos González, Anna Aviñó Chemistry A European Journal, 2025 Chemical modifications of nucleic acids are widely used to tune stability and functionality in therapeutic and nanotechnological applications. Among these, fluorinated cytidine derivatives such as 2′‐fluoro‐arabinocytidine (2′F‐araC) and 2′‐fluoro‐ribocytidine (2′F‐riboC) have been shown to influence i‐motif structures differently, with 2′F‐araC strongly stabilizing and 2′F‐riboC exerting a mildly deleterious effect. In this study, we investigate the impact of gemcitabine (2′‐deoxy‐2′,2′‐difluorocytidine, dFdC) on i‐motif stability. dFdC exhibits small effects in single or double substituted sequences, but a pronounced stabilization when multiple consecutive residues are incorporated. Thermal and pH‐dependent analyses demonstrate that sequences containing fully substituted dFdC maintain i‐motif folding at neutral pH and show enhanced thermal stability. Structural insights suggest that this stabilization arises from a combination of factors, such as hyperconjugative interactions, hydrogen bonding, and dipole alignment, while the adaptable sugar conformation mitigates destabilizing minor groove contacts observed in other more rigid modifications, such as 2′‐F‐riboC. Cooperative interactions among adjacent dFdC residues and potential changes in hydration may play a key factor in reinforcing stability. These results highlight the unique capacity of dFdC to enhance i‐motif robustness and suggest that strategically placed difluoro substitutions can be exploited to design i‐motifs with improved stability, expanding their potential in biotechnology and therapeutic applications.
Preface to the second edition Nucleic Acids Chemistry Modifications and Conjugates for Biomedicine and Nanotechnology, 2025
Nucleic Acids Chemistry: Modifications and Conjugates for Biomedicine and Nanotechnology Eritja, Ramon Nucleic Acids Chemistry Modifications and Conjugates for Biomedicine and Nanotechnology, 2025 This book compiles recent research on the modification of nucleic acids. It covers backbone modifications and conjugation of lipids, peptides and proteins to oligonucleotides and their therapeutic use. Synthesis and application in biomedicine and nanotechnology of aptamers, fluorescent and xeno nucleic acids, DNA repair and artificial DNA are discussed as well. \n \nNovel backbones for therapeutic nucleic acids \nLipid-, peptide- and protein-oligonucleotide conjugates. \nModified DNA nanostructures \nAptamers and DNA catalysts.
Nucleic acids triple helices Arnau Domínguez, Ramon Eritja Nucleic Acids Chemistry Modifications and Conjugates for Biomedicine and Nanotechnology, 2025
DNA nanotechnology for drug delivery Natalia Navarro, Carme Fàbrega, Ramon Eritja Nucleic Acids Chemistry Modifications and Conjugates for Biomedicine and Nanotechnology, 2025
Nucleic acids quadruplex Raimundo Gargallo, Carlos González, Carme Fàbrega, Anna Aviñó, Ramon Eritja Nucleic Acids Chemistry Modifications and Conjugates for Biomedicine and Nanotechnology, 2025
Advances in therapeutic oligonucleotide chemistry Andreia F. Jorge, Santiago Grijalvo, Anna Aviñó, Carme Fàbrega, Ramon Eritja Nucleic Acids Chemistry Modifications and Conjugates for Biomedicine and Nanotechnology, 2025
Oligonucleotide conjugates Andreia F. Jorge, Santiago Grijalvo, Anna Aviñó, Carme Fàbrega, Ramon Eritja Nucleic Acids Chemistry Modifications and Conjugates for Biomedicine and Nanotechnology, 2025
Detection of SARS-CoV-2 Virus by Triplex Enhanced Nucleic Acid Detection Assay (TENADA) Anna Aviñó, Carlos Cuestas-Ayllón, Manuel Gutiérrez-Capitán, Lluisa Vilaplana, Valeria Grazu, Véronique Noé, Eva Balada, Antonio Baldi, Alex J. Félix, Eva Aubets, Simonas Valiuska, Arnau Domínguez, Raimundo Gargallo, Ramon Eritja, M.-Pilar Marco, César Fernández-Sánchez, Jesús Martínez de la Fuente, Carlos J. Ciudad International Journal of Molecular Sciences, 2022
OLIGONUCLEOTIDE THERAPEUTICS. A LONG AND WINDY ROAD TOWARDS FUTURE MEDICINES Chimica Oggi Chemistry Today, 2022
Rational engineering of a human GFP-like protein scaffold for humanized targeted nanomedicines Patricia Álamo, Juan Cedano, Oscar Conchillo-Sole, Olivia Cano-Garrido, Lorena Alba-Castellon, Naroa Serna, Anna Aviñó, Luis Miguel Carrasco-Diaz, Alejandro Sánchez-Chardi, Carlos Martinez-Torró, Alberto Gallardo, Montserrat Cano, Ramon Eritja, Antonio Villaverde, Ramon Mangues, Esther Vazquez, Ugutz Unzueta Acta Biomaterialia, 2021
Advances in therapeutic oligonucleotide chemistry Andreia F. Jorge, Santiago Grijalvo, Anna Aviñó, Carme Fàbrega, Ramon Eritja Nucleic Acids Chemistry Modifications and Conjugates for Biomedicine and Nanotechnology, 2021
Nucleic acids quadruplex Raimundo Gargallo, Carlos González, Carme Fàbrega, Anna Aviñó, Ramon Eritja Nucleic Acids Chemistry Modifications and Conjugates for Biomedicine and Nanotechnology, 2021
Oligonucleotide conjugates and DNA nanotechnology Andreia F. Jorge, Santiago Grijalvo, Anna Aviñó, Carme Fàbrega, Ramon Eritja Nucleic Acids Chemistry Modifications and Conjugates for Biomedicine and Nanotechnology, 2021
Design and engineering of tumor-targeted, dual-acting cytotoxic nanoparticles Eric Voltà-Durán, Naroa Serna, Laura Sánchez-García, Anna Aviñó, Julieta M. Sánchez, Hèctor López-Laguna, Olivia Cano-Garrido, Isolda Casanova, Ramón Mangues, Ramon Eritja, Esther Vázquez, Antonio Villaverde, Ugutz Unzueta Acta Biomaterialia, 2021
Small interfering RNAs (siRNAs) in cancer therapy: a nano-based approach Ghanbar Mahmoodi Chalbatani, Hassan Dana, Elahe Gharagouzloo, Santiago Grijalvo, Ramon Eritja, Craig D. Logsdon, Fereydon Memari, Seyed Rohollah Miri, Mahdi Rezvani Rad, Vahid Marmari International Journal of Nanomedicine, 2019
Selective depletion of metastatic stem cells as therapy for human colorectal cancer María Virtudes Céspedes, Ugutz Unzueta, Anna Aviñó, Alberto Gallardo, Patricia Álamo, Rita Sala, Alejandro Sánchez‐Chardi, Isolda Casanova, María Antònia Mangues, Antonio Lopez‐Pousa, Ramón Eritja, Antonio Villaverde, Esther Vázquez, Ramón Mangues EMBO Molecular Medicine, 2018
Glucose–Nucleobase Pseudo Base Pairs: Biomolecular Interactions within DNA Empar Vengut‐Climent, Irene Gómez‐Pinto, Ricardo Lucas, Pablo Peñalver, Anna Aviñó, Célia Fonseca Guerra, F. Matthias Bickelhaupt, Ramón Eritja, Carlos González, Juan C. Morales Angewandte Chemie International Edition, 2016
Impact of methylation on the physical properties of DNA Alberto Pérez, Chiara Lara Castellazzi, Federica Battistini, Kathryn Collinet, Oscar Flores, Ozgen Deniz, Maria Luz Ruiz, David Torrents, Ramon Eritja, Montserrat Soler-López, Modesto Orozco Biophysical Journal, 2012
Structure of triplex DNA in the Gas phase Annalisa Arcella, Guillem Portella, Maria Luz Ruiz, Ramon Eritja, Marta Vilaseca, Valérie Gabelica, Modesto Orozco Journal of the American Chemical Society, 2012
Apolar carbohydrates as DNA capping agents Ricardo Lucas, Empar Vengut-Climent, Irene Gómez-Pinto, Anna Aviñó, Ramón Eritja, Carlos González, Juan C. Morales Chemical Communications, 2012
Analysis of interaction between dendriplexes and bovine serum albumin Dzmitry Shcharbin, Elzbieta Pedziwiatr, Louis Chonco, Jesus F. Bermejo-Martín, Paula Ortega, F. Javier de la Mata, Ramon Eritja, Rafael Gómez, Barbara Klajnert, Maria Bryszewska, M Angeles Muñoz-Fernandez Biomacromolecules, 2007
Comparative uptake of phosphorothioate oligonucleotides by human peripheral blood mononuclear cells from newborns and adults European Journal of Scientific Research, 2006
Erratum: Synthesis of oligodeoxynucleotides containing 2-substituted guanine derivatives using 2-fluoro-2'-deoxyinosine as common nucleoside precursor (Nucleosides, Nucleotides and Nucleic Acids (1997) 16:10-11 (2035- 2051)) Nucleosides Nucleotides and Nucleic Acids, 2000
Preparation of oligonucleotides containing nonnatural base analogs Ramon Eritja, Viviane Adam, Anna AviñTó, Antonio R. Díaz, Carme Fàbrega, Elisenda Ferrer, Morten GrøStli, Ramón Güimil García, Mechtild Hofmann, Víctor E. Márquez, Marten Wiersma Nucleosides and Nucleotides, 1997
Kinetic studies of MvaI DNA methyltransferase interaction with modified oligonucleotide duplexes Biochemistry and Molecular Biology International, 1995
Purification and characterization of an inducible Escherichia coli DNA polymerase capable of insertion and bypass at abasic lesions in DNA Journal of Biological Chemistry, 1988
Equilibrium between a wobble and ionized base pair formed between fluorouracil and guanine in DNA as studied by proton and fluorine NMR Journal of Biological Chemistry, 1988
G-quadruplexes as therapeutic platforms for anticancer drug delivery: from intrinsic cytotoxicity to drug delivery and nanotechnology A Domínguez, N Navarro, A Aviñó, C Fàbrega, R Eritja Expert Opinion on Drug Delivery , 2026 2026 Citations: 1
Covalent functionalization of polymeric nanoparticles prepared from nano-emulsion templates for gene silencing and antioxidant delivery at neuronal level M Bel-Esteve, M Carrasco, N Moral, A Aviñó, C Fàbrega, R Eritja, ... International Journal of Pharmaceutics, 126918 , 2026 2026
Engineering G-quadruplex aptamer-5-fluoro-2′-deoxyuridine conjugates: Impact of tail orientation and RNA spacer insertion on structure and antitumor activity N Navarro, D Benigno, C Aliberti, A Virgilio, A Galeone, R Eritja, ... International journal of biological macromolecules, 151523 , 2026 2026 Citations: 1
Enhanced muscle uptake of chemically optimized miR-23b antisense oligonucleotides as lead compounds for Myotonic Dystrophy type 1 I González-Martínez, E Cerro-Herreros, M Carrascosa-Sàez, ... The American Journal of Human Genetics 113 (3), 529-547 , 2026 2026
Replication Data for: Conjugation strategy shapes antitumor efficacy and enables dose-sparing in non-antibody protein nanoconjugates LC Alba Castellon, U Unzueta Elorza, R Mangues, A Rueda, D Paez, ... 2026
Conjugation strategy shapes antitumor efficacy and enables dose-sparing in non-antibody protein nanoconjugates. A Rueda, A Garcia-Leon, LA Arena, JI Mendoza, A Aviñó, C Fabrega, ... Materials Today Bio, 102698 , 2025 2025
Enhanced i‐Motif Stability through Consecutive 2′, 2′‐Difluorocytidine Incorporation A Domínguez, C Cabrero, I Gómez‐Pinto, C Fàbrega, R Gargallo, R Eritja, ... Chemistry–A European Journal 31 (71), e03008 , 2025 2025
8 Oligonucleotide conjugates AF Jorge, S Grijalvo, A Aviñó, C Fàbrega, R Eritja Nucleic Acids Chemistry: Modifications and Conjugates for Biomedicine and … , 2025 2025
5 Nucleic acids triple helices A Domínguez, R Eritja Nucleic Acids Chemistry: Modifications and Conjugates for Biomedicine and … , 2025 2025
9 DNA nanotechnology for drug delivery N Navarro, C Fàbrega, R Eritja Nucleic Acids Chemistry: Modifications and Conjugates for Biomedicine and … , 2025 2025
Nucleic Acids Chemistry: Modifications and Conjugates for Biomedicine and Nanotechnology R Eritja Walter de Gruyter GmbH & Co KG , 2025 2025 Citations: 2
The Effect of 2′ F-RNA on I-Motif Structure and Stability C Ugedo, A Domínguez, I Gómez-Pinto, R Eritja, C González, A Aviñó Molecules 30 (17), 3561 , 2025 2025 Citations: 1
Resolution of complex mixtures of duplex and antiparallel triplex DNA structures by capillary electrophoresis and multivariate analysis K Hatamli, R Eritja, E Giménez, F Benavente, R Gargallo Talanta 288, 127616 , 2025 2025 Citations: 2
Unraveling the Amplification-Free Quantitative Detection of Viral RNA in Nasopharyngeal Swab Samples Using a Compact Electrochemical Rapid Test Device M Gutiérrez-Capitán, E Balada, A Avino, L Vilaplana, R Galve, A Lacoma, ... Analytical chemistry 97 (22), 11863-11873 , 2025 2025 Citations: 3
Modified Bis-pyrimidine Clamps for Triplex Formation and Their Use in SARS-CoV-2 Detection A Dominguez, R Gargallo, C Cuestas-Ayllón, I Gomez-Pinto, C Fàbrega, ... ACS omega 10 (22), 23535-23548 , 2025 2025 Citations: 2
Targeted Tumor Microenvironment Delivery of Floxuridine Prodrug via Soluble Silica Nanoparticles in Malignant Melanoma as a Model for Aggressive Cancer Treatment A Ramos‐Valle, A Domínguez, N Navarro, A Márquez‐López, A Aviñó, ... Small 21 (20), 2407752 , 2025 2025 Citations: 4
On the interaction of anticancer G-quadruplex ligands with GalNAc-functionalized G-quadruplex-forming carriers for selective recognition and treatment of hepatocellular carcinoma A Clua, C Fàbrega, D Musumeci, F Doria, V Pirota, F Ghirga, C Platella, ... Bioorganic chemistry 157, 108299 , 2025 2025 Citations: 3
Systematic study of hybrid triplex topology and stability suggests a general triplex-mediated regulatory mechanism V Genna, G Portella, A Sala, M Terrazas, I Serrano-Chacón, J González, ... Nucleic acids research 53 (5), gkaf170 , 2025 2025 Citations: 8
Assessment of methodologies based on the formation of antiparallel triplex DNA structures and fluorescent silver nanoclusters for the detection of pyrimidine-rich sequences C Poyato, J Pacheco, A Domínguez, R Eritja, A Aviñó, R Gargallo Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 329, 125567 , 2025 2025 Citations: 2
Polypurine Reverse Hoogsten hairpins as a potential therapeutic tool for COVID-19 infection V Noe, S Valiuska, P Nogales-Altozano, J Rojas, A Avino, R Eritja, ... HUMAN GENE THERAPY 36 (3-4), E338-E338 , 2025 2025
MOST CITED SCHOLAR PUBLICATIONS
Carbon nanotubes with DNA recognition KA Williams, PTM Veenhuizen, BG de la Torre, R Eritja, C Dekker Nature 420 (6917), 761-761 , 2002 2002 Citations: 708
Convergent solid-phase peptide synthesis P Lloyd-Williams, M Gairi, G Jou, R Eritja 1993 Citations: 309
Base pairing and mutagenesis: observation of a protonated base pair between 2-aminopurine and cytosine in an oligonucleotide by proton NMR. LC Sowers, GV Fazakerley, R Eritja, BE Kaplan, MF Goodman Proceedings of the National Academy of Sciences 83 (15), 5434-5438 , 1986 1986 Citations: 303
Nucleotide insertion kinetics opposite abasic lesions in DNA. SK Randall, R Eritja, BE Kaplan, J Petruska, MF Goodman Journal of Biological Chemistry 262 (14), 6864-6870 , 1987 1987 Citations: 299
Small interfering RNAs (siRNAs) in cancer therapy: a nano-based approach G Mahmoodi Chalbatani, H Dana, E Gharagouzloo, S Grijalvo, R Eritja, ... International journal of nanomedicine, 3111-3128 , 2019 2019 Citations: 293
Crystal structure of a DNA Holliday junction M Ortiz-Lombardía, A González, R Eritja, J Aymamí, F Azorín, M Coll nature structural biology 6 (10), 913-917 , 1999 1999 Citations: 277
Biochemical basis of SOS-induced mutagenesis in Escherichia coli : Reconstitution of in vitro lesion bypass dependent on the UmuD′ 2 C mutagenic complex and … M Tang, I Bruck, R Eritja, J Turner, EG Frank, R Woodgate, M O’Donnell, ... Proceedings of the National Academy of Sciences 95 (17), 9755-9760 , 1998 1998 Citations: 248
Biofunctionalization of silica-coated CdTe and gold nanocrystals A Schroedter, H Weller, R Eritja, WE Ford, JM Wessels Nano Letters 2 (12), 1363-1367 , 2002 2002 Citations: 237
Fundamental aspects of the nucleic acid i-motif structures S Benabou, A Aviñó, R Eritja, C González, R Gargallo RSC advances 4 (51), 26956-26980 , 2014 2014 Citations: 235
A novel p34cdc2-binding and activating protein that is necessary and sufficient to trigger G2/M progression in Xenopus oocytes I Ferby, M Blazquez, A Palmer, R Eritja, AR Nebreda Genes & development 13 (16), 2177-2189 , 1999 1999 Citations: 227
Label-free DNA biosensors based on functionalized carbon nanotube field effect transistors MT Martínez, YC Tseng, N Ormategui, I Loinaz, R Eritja, J Bokor Nano letters 9 (2), 530-536 , 2009 2009 Citations: 218
Spectroscopic and calorimetric characterizations of DNA duplexes containing 2-aminopurine SM Law, R Eritja, MF Goodman, KJ Breslauer Biochemistry 35 (38), 12329-12337 , 1996 1996 Citations: 218
Abasic translesion synthesis by DNA polymerase β violates the “A-rule”: Novel types of nucleotide incorporation by human DNA polymerase β at an abasic lesion in different … E Efrati, G Tocco, R Eritja, SH Wilson, MF Goodman Journal of Biological Chemistry 272 (4), 2559-2569 , 1997 1997 Citations: 216
A novel cationic niosome formulation for gene delivery to the retina G Puras, M Mashal, J Zárate, M Agirre, E Ojeda, S Grijalvo, R Eritja, ... Journal of Controlled Release 174, 27-36 , 2014 2014 Citations: 211
Transgenic rice plants expressing the antifungal AFP protein from Aspergillus giganteus show enhanced resistance to the rice blast fungus Magnaporthe grisea M Coca, C Bortolotti, M Rufat, G Peñas, R Eritja, D Tharreau, AM Del Pozo, ... Plant Molecular Biology 54 (2), 245-259 , 2004 2004 Citations: 211
The structure of plasmid‐encoded transcriptional repressor CopG unliganded and bound to its operator FX Gomis‐Rüth, M Sola, P Acebo, A Párraga, A Guasch, R Eritja, ... The EMBO journal 17 (24), 7404-7415 , 1998 1998 Citations: 208
Efficient self-assembly in water of long noncovalent polymers by nucleobase analogues BJ Cafferty, I Gállego, MC Chen, KI Farley, R Eritja, NV Hud Journal of the American Chemical Society 135 (7), 2447-2450 , 2013 2013 Citations: 204
Boronic acid-modified alginate enables direct formation of injectable, self-healing and multistimuli-responsive hydrogels A Pettignano, S Grijalvo, M Haering, R Eritja, N Tanchoux, F Quignard, ... Chemical communications 53 (23), 3350-3353 , 2017 2017 Citations: 200
Water‐soluble carbosilane dendrimers: synthesis biocompatibility and complexation with oligonucleotides; evaluation for medical applications JF Bermejo, P Ortega, L Chonco, R Eritja, R Samaniego, M Müllner, ... Chemistry–A European Journal 13 (2), 483-495 , 2007 2007 Citations: 190
Biodegradable liposome-encapsulated hydrogels for biomedical applications: A marriage of convenience S Grijalvo, J Mayr, R Eritja, DD Díaz Biomaterials science 4 (4), 555-574 , 2016 2016 Citations: 189