Ahmed, Akeem Olayiwola
@unilorin.edu.ng
Senior Assistant Professor, Faculty of Veterinary Medicine
Senior Assistant Professor, Faculty of Veterinary Medicine
University of Ilorin, Ilorin, Kwara State, Nigeria
Dr Akeem O. AHMED was born in Ilorin, Nigeria on 10th April, 1986. He completed his Primary School Certificate in 1992, West African School Certificate in 2003. He obtained his Doctor Veterinary Medicine (DVM) from University of Maiduguri, Maiduguri Nigeria in 2012, M.Sc. in Ahmadu Bello University, Zaria in 2017 and currently pursuing his Ph.D. in University of Ilorin. He joined the University of Ilorin in 2015 as Lecturer II and rose to Lecturer I in 2017. He belongs to various professional and community associations. He has attended many national and international training programs, conferences and workshops in India. He has many awards to his credit, these include University of Ilorin study Fellowship Award 2019 till Date; Director’s List of Honour, Uka Tarsadia University, India 2019; N.G. Patel Grants Award for C.G. Patel (Bhakta) Grant in Biotechnology, 2018 and won Werner Baltes fellowship at German federal Institute (BFR), Berlin, Germany, 2023.
RESEARCH, TEACHING, or OTHER INTERESTS
Microbiology, Molecular Biology, Aquatic Science, Veterinary
FUTURE PROJECTS
Characterization of Campylobacter from human, food animals and environment in Nigeria and other African Countries using one health approach.
Campylobacteriosis is the leading cause of foodborne gastroenteritis in the world. The epidemiology of Campylobacter infection is well established in the developed world but there is no reliable and robust data on epidemiology of Campylobacter infection in Africa.
Applications Invited
Grant and collaborators across Africa and beyond
Scopus Publications
Scopus Publications
Foluke Olajumoke Jemilehin, Adelekan Oluseyi Okunlade, Ridwan Olamilekan Adesola, Happiness Chibuzo Obiechefu, and Akeem Olayiwola Ahmed
Elsevier BV
Akeem O. Ahmed, Akorede G. Jimoh, Aremu Abdulfatai, Raji A. Moshood, Adamu F. Lawan, Olabode P. Mayowa, and Raufu A. Ibrahim
Springer Science and Business Media LLC
Hannah-Marie Martiny, Patrick Munk, Alessandro Fuschi, Ágnes Becsei, Nikiforos Pyrounakis, Christian Brinch, , D. G. Joakim Larsson, Marion Koopmans, Nawel Zaatout,et al.
Springer Science and Business Media LLC
Abstract Antimicrobial resistance genes (ARGs) have rapidly emerged and spread globally, but the pathways driving their spread remain poorly understood. We analyzed 1240 sewage samples from 351 cities across 111 countries, comparing ARGs known to be mobilized with those identified through functional metagenomics (FG). FG ARGs showed stronger associations with bacterial taxa than the acquired ARGs. Network analyses further confirmed this and showed potential for source attribution of both known and novel ARGs. The FG resistome was more evenly dispersed globally, whereas the acquired resistome followed distinct geographical patterns. City-wise distance-decay analyses revealed that the FG ARGs showed significant decay within countries but not across regions or globally. In contrast, acquired ARGs showed decay at both national and regional scales. At the variant level, both ARG groups had significant national and regional distance-decay effects, but only FG ARGs at a global scale. Additionally, we observed stronger distance effects in Sub-Saharan Africa and East Asia compared to North America. Our findings suggest that differential selection and niche competition, rather than dispersal, shape the global resistome patterns. A limited number of bacterial taxa may act as reservoirs of latent FG ARGs, highlighting the need of targeted surveillance to mitigate future resistance threats.
Nathalie Worp, David F. Nieuwenhuijse, Ray W. Izquierdo-Lara, Claudia M. E. Schapendonk, Christian Brinch, Emilie Egholm Bruun Jensen, Patrick Munk, Rene S. Hendriksen, , Frederik Duus Møller,et al.
Springer Science and Business Media LLC
Paul Habila Mamman, Bala Ningi Umar, Abubakar Nafiu Kakudi, Akeem O. Ahmed, Kennedy Chah, and Haruna Makanjuola Kazeem
Egyptian Knowledge Bank
Austin E Schumacher, Peng Zheng, Ryan M Barber, Bhoomadevi A, Mohammad Amin Aalipour, Hasan Aalruz, Hazim S Ababneh, Ukachukwu O Abaraogu, Cristiana Abbafati, Nasir Abbas,et al.
Elsevier BV
Simon I Hay, Kanyin Liane Ong, Damian F Santomauro, Bhoomadevi A, Mohammad Amin Aalipour, Hasan Aalruz, Hazim S Ababneh, Ukachukwu O Abaraogu, Biruk Beletew Abate, Cristiana Abbafati,et al.
Elsevier BV
Ibrahim A. Raufu, Opeyemi U. Lawal, Valeria R. Parreira, Mitra Soni, Harmanpreet Kaur, Akeem O. Ahmed, Abdulfatai Aremu, Ahmad I. Al-Mustapha, and Lawrence Goodridge
American Society for Microbiology
ABSTRACT Salmonella enterica is a zoonotic pathogen that poses a significant threat to public health. It is the leading cause of bacterial foodborne illness with complex transmission dynamics across human, animal, and environmental pathways. Here, we report draft genomes of 25 S . enterica isolates recovered from different animals.
Ibrahim A. Raufu, Opeyemi U. Lawal, Valeria R. Parreira, Mitra Soni, Harmanpreet Kaur, Akeem O. Ahmed, Abdulfatai Aremu, Ahmad I. Al-Mustapha, and Lawrence Goodridge
American Society for Microbiology
ABSTRACT Citrobacter cronae inhabits the intestines of humans and has been isolated from stool and rectal swabs of immunosuppressed patients. However, its role as a zoonotic pathogen has not been fully studied. Here, we present draft genomes of 11 C . cronae isolates obtained from the food-animal production chain.
Akeem O. Ahmed, James A. Ameh, Mustapha B. Abubakar, and Ibrahim A. Raufu
Elsevier BV
, Akeem O. AHMED, Abdulfatai AREMU, , Fatima L ADAMU, , Ganiu J. AKOREDE, , Ismail A. ADEYEMO, ,et al.
AVES YAYINCILIK A.Ş.
Patrick Munk, Christian Brinch, Frederik Duus Møller, Thomas N. Petersen, Rene S. Hendriksen, Anne Mette Seyfarth, Jette S. Kjeldgaard, Christina Aaby Svendsen, Bram van Bunnik, Fanny Berglund,et al.
Springer Science and Business Media LLC
Ganiu Jimoh Akorede, , Suleiman Folorunsho Ambali, Aisha Omobolanle Olatunji, Abdulfatai Aremu, Akeem Olayiwola Ahmed, Afisu Basiru, Mistura Oyebisi Azeez, Fatima Sanusi, Rafiu Adebisi Kadir,et al.
Negah Scientific Publisher
Background: Drugs are the mainstay of the clinical management of epilepsy. Carbamazepine (CBZ) is commonly used for treating epilepsy and neuropathic pain. This drug has been reported to have toxic effects on the hematological system due to its induction of oxidative stress. This study aimed to investigate the protective effects of vitamin C against hematological and thyroid toxicities caused by the chronic use of carbamazepine in male Wistar rats. Methods: Thirty-two adult Wistar rats were categorized randomly into four groups of eight rats each and treated as follows: Group 1 received distilled water (2 mL/kg); group 2 was treated with vitamin C (100 mg/kg); group 3 received carbamazepine (20 mg/kg), and group 4 was pre-treated with vitamin C (100 mg/kg) and given carbamazepine (20 mg/kg) 30 min later. All treatments were administered via gavage once per day over fifteen consecutive weeks. The rats’ blood samples were tested for changes in hematological parameters while the sera were evaluated for liver biochemical enzymes and thyroid hormone levels. Results: The results revealed that pre-treatment with vitamin C protected against alterations in parameters associated with hematological and thyroid toxicities. Conclusion: Based on the study results, it was concluded that: a) The chronic use of CBZ caused hematological and thyroid toxicities, and b) Vitamin C protected against these toxicities. Therefore, it is highly likely that vitamin C has the potential to protect experimental animals against injuries induced by CBZ to the liver, blood cells, and hypothalamic-pituitary-thyroid axis in a Wistar rat model.
Patrick Munk, Christian Brinch, Frederik Duus Møller, Thomas N. Petersen, Rene S. Hendriksen, Anne Mette Seyfarth, Jette S. Kjeldgaard, Christina Aaby Svendsen, Bram van Bunnik, Fanny Berglund,et al.
Springer Science and Business Media LLC
AbstractAntimicrobial resistance (AMR) is a major threat to global health. Understanding the emergence, evolution, and transmission of individual antibiotic resistance genes (ARGs) is essential to develop sustainable strategies combatting this threat. Here, we use metagenomic sequencing to analyse ARGs in 757 sewage samples from 243 cities in 101 countries, collected from 2016 to 2019. We find regional patterns in resistomes, and these differ between subsets corresponding to drug classes and are partly driven by taxonomic variation. The genetic environments of 49 common ARGs are highly diverse, with most common ARGs carried by multiple distinct genomic contexts globally and sometimes on plasmids. Analysis of flanking sequence revealed ARG-specific patterns of dispersal limitation and global transmission. Our data furthermore suggest certain geographies are more prone to transmission events and should receive additional attention.
Philip Babatunde, Akeem Ahmed, Mahmoud Shuaib, Mashood Raji, Abdulfatai Aremu, Ganiu Akorede, Abdulwahab Sulyman, Ahmadu Umaru, and Ibrahim Raufu
Egypts Presidential Specialized Council for Education and Scientific Research
Background: worldwide activities in the countries. The present study was carried out to determine the isolation rate and antimicrobial susceptibility profiles of Salmonella species from ruminants slaughtered for human consumption at the two major abattoirs in Ilorin, Kwara State. Methods : Between November, 2019 and February, 2020, a total 500 samples were collected from the two major abattoirs in Ilorin metropolis (cattle, n = 240; goat, n = 260). Salmonella species were isolated and identified using standard bacteriological techniques. The isolates were subjected antimicrobial susceptibility test using Kirby Bauer disk diffusion assay. Results : 20 (4 %) Salmonella isolates were obtained, there was no significant statistical difference between the isolation rates from cattle (3.75 %) and the small ruminant (4.23 %). Varying degree of resistance patterns were obtained with high proportion of the isolates (> 60 %) displaying resistance to penicillin and cephalosporin tested while low resistant phenotypes (5 %) were observed against quinolones. The isolates were pan-susceptible to gentamicin. Conclusion : The study documented multidrug resistant Salmonella isolates from ruminants slaughtered for human consumption. It is recommended that further studies to characterize the isolates will assist in recommending the appropriate control strategies to prevent the transmission of resistant Salmonella strains to human via food chain.
Abdulfatai Aremu, Olayinka Oridupa, Ganiu Akorede, Afisu Basiru, and Akeem Ahmed
ScopeMed
Diabetes mellitus (DM) has been known to be a major health challenge that have harmful effects on the quality of life globally as a result of its numerous complications. One of the most prevalent secondary complication of the disease is male reproductive system dysfunction. Oral hypoglycaemic drugs are used for managing diabetes but their use has been reported to possess side effects on male reproductive organ leading to significant alteration of spermatogenesis. Lawsonia inermis Linn are used in the treatment of both infectious and non-infectious diseases like poliomyelitis, measles, menorrhagia, vaginal discharge and leucorrhoea. Lawsonia inermis leaves were sectioned using N-hexane, ethyl acetate and methanol. Fractions obtained were assessed for their modulatory effect. Thirteen groups of diabetic rats (n=5) were orally administered 25, 50 and 100 mg/kg of each of the three partitioned fraction, metformin (500 mg/kg), glibenclamide (5 mg/kg), while untreated hyperglycaemic and normoglycaemic rats received distilled water for 28 days. Sperm parameters showed significant (p<0.05) decreased motility in most treatment group compared to normoglycaemic control but significant improvement was observed in sperm parameters when compared to untreated diabetic control. The sperm volume and live/dead ratio of diabetic treated rats showed little or no significant alteration in all the administered dosage compared to both diabetic and non-diabetic controls. Methanol fraction at 100mg/kg presented non-significant (p>0.05) decreased total abnormal sperm cell compared to normoglycemic control. Diabetic and non-diabetic control had a greater number of spermatozoa with tailless head abnormality compared to Lawsonia inermis treatment groups. Histopathology result of diabetic untreated testes showed histological abnormality represented by degenerated seminiferous tubules when compared to normoglycemic control cases. Treatment groups with fractions of Lawsonia inermis presents normal histological appearance. We concluded that this study showed that Lawsonia inermis has significant modulatory or ameliorative effect on various sperm abnormalities and testicular degeneration seen in diabetic ones.
Ganiu Jimoh Akorede, Suleiman Folorunsho Ambali, Aisha Omobolanle Olatunji, Abdulfatai Aremu, Afisu Basiru, Akeem Olayiwola Ahmed, Mistura Olabisi Azeez, Isiaku Abdulmajeed, and Rafiu Adebisi Kadir
Elsevier BV
Femi J. Fawole, Rihanat O. Yisa, Oluwole O. Jayeoba, Ibrahim Adeshina, Akeem O. Ahmed, and Benjamin O. Emikpe
Hindawi Limited
A 56-day feeding trial was conducted to evaluate the dietary effect of Nigeria polyherbal mixture (PHB) on growth, haemato-immune parameters, antioxidant enzyme activities, and intestinal morphometry of African catfish, Clarias gariepinus. Four diets were formulated with PHB powder at inclusion of 0 g/kg (control), 0.5 g/kg (PHB 0.5), 1.0 g/kg (PHB 1.0), and 2.0 g/kg (PHB 2.0) and fed to African catfish ( 6.32 ± 0.02 g /fish, 15 fish/50 L tank) in triplicates. Fish fed PHB 2.0 recorded higher final weight, weight gain, and specific growth rate ( p < 0.05 ) compared to the control. There were no statistical differences ( p > 0.05 ) in feed conversion ratio and protein efficiency ratio among the dietary groups. The haematological profile indicates that the fish fed PHB-1.0 had higher Hb, RBCs count, and Hct, and blood performance ( p < 0.05 ) compared to the control. ALT levels were found higher in the control and the lowest values recorded in PHB groups ( p < 0.05 ); however, AST did not differ significantly among the groups ( p > 0.05 ). The highest heterophil counts and respiratory burst activity were recorded in PHB-1.0 and PHB-0.5 and PHB-2.0, respectively, while a numerically improved total immunoglobulin value was recorded in PHB-0.5 compared to the control ( p > 0.05 ). Antioxidant enzymes such as superoxide dismutase and catalase had a significant improvement in fish fed PHB-based diet compared to the control ( p < 0.05 ), while glutathione peroxidase showed no statistical differences between the groups ( p > 0.05 ). Intestinal morphometric measurements showed that the fish fed PHB-1.0 had the highest villus height, area of absorption, and villus height/cryptal depth ratio compared to the control. Muscle thickness increased ( p < 0.05 ) with increasing PHB level with the highest value recorded PHB-2.0. In conclusion, dietary PHB could improve growth, blood profile, immunity, antioxidant enzyme capacity, and intestinal morphometry of African catfish without any significant alteration in the liver function enzymes.
Ahmed Akeem and
International Association for Food Protection
Campylobacter is a leading cause of bacterial gastro-enteritis worldwide. This study determined the phenotypic characteristics of Campylobacter from ruminants slaugh-tered in two major abattoirs in Ilorin metropolis of Kwara state, Nigeria. In total, 350 fecal samples were collected from beef cattle (n = 200) and goat (n = 150). Campylobacter was isolated and phenotypically characterized using standard bacteriological methods. Seventy (20%) of the samples were positive for Campylobacter. The isolation rate of Campylobacter from female animals (11.71%) was higher than that of males (8.28%), albeit there was no significant difference (P > 0.05). Similarly, the rate of isolation of Campylobacter from bovine (12.86%) was not statistically significant (P > 0.05) from that of caprine (7.14%) species. Only five (7.14%) of the total isolates were Campylobacter jejuni. All isolates were resistant to nalidixic acid and pan-susceptible to gentamicin, but there were different rates of antimicrobial resistance to other tested antibiotics. There was also high rate of resistance to cefotaxime (83%) and ampicillin (76%), and 53% of the isolates displayed multidrug resistance phenotypes. The study established 20% Campylobacter contamination of ruminants slaughtered in the two major abattoirs in Ilorin, and most of the isolates were multidrug resistant. Further study is recommended to molecularly characterize the spe-cies of Campylobacter circulating in the study area.
M. A. Raji, H. M. Kazeem, K. A. Magyigbe, A. O. Ahmed, D. N. Lawal, and I. A. Raufu
Hindawi Limited
Salmonellosis is one of the most common and widely distributed food-borne diseases, and the presence of antimicrobial-resistant Salmonella in poultry and poultry products is a global public health problem. Therefore, a cross-sectional study was conducted from November 2016 to July 2017 with an aim of determining the isolation rates of Salmonella species from the intestinal contents of slaughtered chickens, the most common serotypes that invade and colonize the tissues of chickens in Ilorin, and the susceptibilities of the isolated species to commonly used antibiotics. Four hundred samples of intestinal contents from apparently healthy slaughtered chickens and one hundred ready-to-eat chicken gizzards in Ilorin, Kwara State, were examined for the presence of Salmonella and their serotypes. Salmonellae were isolated and identified according to the techniques recommended by the World Health Organization: preenrichment, selective plating, biochemical testing, and serotyping. A total number of forty-three (43) Salmonella isolates consisting of 33 from intestinal contents and 10 from ready-to-eat chicken gizzards were isolated and identified. There was an overall Salmonella prevalence rate of 8.6% (43/500), and the isolates were distributed as follows: gizzard, 2% ( n = 10 ) and intestinal contents, 6.6% ( n = 33 ). The predominant serovars were Salmonella enterica subsp. enterica serovar 45: d: 1, 7 (16) and S. Haifa (5). All ready-to-eat chicken gizzards were associated with Salmonella enterica subsp. enterica serovar 45: d: 1, 7 (5). The Salmonella from intestinal contents belong to Salmonella enterica subsp. enterica serovars 45: d: 1, 7 (11) and S. Haifa (5). Salmonella species isolated were 100% resistant to ciprofloxacin, ampicillin, and ceftazidime. This is followed by cloxacillin (81%), tetracycline (75%), and sulfamethoxazole (67%). The Salmonella isolates were, however, 100% sensitive to enrofloxacin, 74% to streptomycin, and 72% to gentamycin antibiotics. The most common serotype was S. enterica subsp. enterica serovar 45: d: 1, 7. All the twenty five Salmonella serovars consisting of twenty-one serotypes ( n = 21 ), two of the Salmonella that could not be cultured after enrichment, and the two that were contaminated with Proteus possessed the virulence genes of invA and stn. The Salmonella enterica subsp. enterica serovar 45: d: 1, 7 and S. Haifa possess virulence genes so they are potentially virulent for humans in this area. The national and local health authorities in Nigeria should improve hygiene measures especially at retail slaughter markets to reduce salmonellosis which is one of the most important food-borne diseases in humans.
Nusirat Elelu, Adefolake Ayinke Bankole, Ramat Jummai Musa, Ismail Ayoade Odetokun, Musa Rabiu, Khalid Talha Biobaku, Abdulfatai Aremu, Akeem Olayiwola Ahmed, Mohammed Ibraheem Ghali, Mashood Abiola Raji,et al.
Public Library of Science (PLoS)
The persistent and highly transmissible Coxiella burnetii is a neglected infection that negatively affects reproductive parameters of livestock. It is also of zoonotic importance and has been reported to cause devastating human infections globally. Domestic ruminants represent the most frequent source of human infection. Data from Nigeria are very few and outdated. There is a significant gap in up-to-date information on the exposure, spatial distribution and risk factors of infection of this important disease. The exposure to C. burnetii was determined using sensitive serological assays in cattle and small ruminants. A total of 538 animals made up of 268 cattle and 270 small ruminants were sampled from three northern Nigerian states. The proportion of cattle sampled that were seropositive from the study locations were: Kwara 14/90 (15.6%; 95% CI: 8.8–24.7); Plateau 10/106 (9.43%; 95% CI: 4.6–16.7) and Borno 4/72 (5.56%; 95% CI: 1.5–13.6) states. Lower seroprevalence was recorded among the small ruminants sampled, with positives recorded from sheep and goat sampled from only Kwara state 6/184 (3.3%; 95% CI: 1.2–7.0); while none of the small ruminants sampled from Plateau were seropositive. The results of the bivariate analysis showed that none of the tested independent variables (village, age group, sex, breed of cattle, presence of ticks, reproductive status, and management system) were statistically significant factors associated with seropositivity of cattle for antibodies to C. burnetii. Stakeholders involved in animal husbandry should be duly educated on proper disposal of birth products as well as bodily fluids in order to reduce environmental contamination, persistence and human infection.
Samson A. Oyeyinka, Suliat O. Ayinla, Christiana T. Sanusi, Olaide A. Akintayo, Ajibola B. Oyedeji, John O. Oladipo, Ahmed O. Akeem, Abdul‐Hameed A. Badmos, Abiodun A. Adeloye, and Siaka S. Diarra
Hindawi Limited
Samson A. Oyeyinka, Adedoyin I. Adebayo, Adewumi T. Oyeyinka, Ahmed O. Akeem, Taofeeq Garuba, and Adebola O. Oladunjoye
Hindawi Limited
RECENT SCHOLAR PUBLICATIONS
RESEARCH OUTPUTS (PATENTS, SOFTWARE, PUBLICATIONS, PRODUCTS)
Patent: I was part of the research group that isolated the novel strain of Listeria named Listeria ilorinesis
Listeria ilorinensis sp. nov., isolated from cow milk cheese in Nigeria (DOI 10.1099/