ADAM17 and its proteolytic targets in disease pathogenesis Abdulbasit Amin, Marina Badenes FEBS Journal, 2026 ADAM17, from the disintegrin and metalloproteinase (ADAM) family, also called tumor necrosis factor converting enzyme (TACE), is a pleiotropic protease with more than 90 substrates, including growth factors, cytokines, receptors, and adhesion molecules. The biology of ADAM17 has been extensively studied, mainly as a regulator of epidermal growth factor receptor (EGFR) and tumor necrosis factor (TNF) signaling pathways, which are crucial for growth and inflammation, respectively. Consequently, this protease has been considered a major target to treat human cancers and inflammatory disorders. Moreover, it is involved in the pathobiology of numerous other disease types. This review summarizes the current understanding of ADAM17 and the involvement of its targets in inflammation, cancer, and cardiovascular and metabolic diseases.
Glucagon in glucose homeostasis and metabolic disease: From physiology to therapeutics Abdulbasit Amin, Toyin Mohammed Salman Journal of Basic and Clinical Physiology and Pharmacology, 2025 Glucagon, a key hormone in glucose homeostasis, plays a central role in maintaining blood glucose levels through hepatic glycogenolysis and gluconeogenesis. Historically, glucagon secretion was believed to be primarily regulated by insulin via the “insulin switch-off” hypothesis, where reduced insulin levels triggered glucagon release. However, this view has been revisited as emerging evidence highlights the complexity of glucagon regulation. New studies demonstrate that glucose itself, along with amino acids and fatty acid oxidation, directly influences glucagon secretion, challenging the insulin-centric perspective. These findings reveal the metabolic versatility of pancreatic α-cells and their capacity to adapt to nutrient availability. Recent therapeutic innovations, such as glucagon receptor antagonists, dual GLP-1/glucagon receptor agonists, and modulators of hepatic glucagon signalling, offer promising strategies to mitigate hyperglycemia, improve energy balance, and address metabolic dysregulation. This review provides an in-depth analysis of glucagon’s role in health and disease, emphasizing its therapeutic potential in managing diabetes and related metabolic conditions.
The ADAM17 sheddase complex regulator iTAP/Frmd8 modulates inflammation and tumor growth Marina Badenes, Emma Burbridge, Ioanna Oikonomidi, Abdulbasit Amin, Érika de Carvalho, et al. Life Science Alliance, 2023 The metalloprotease ADAM17 is a sheddase of key molecules, including TNF and epidermal growth factor receptor ligands. ADAM17 exists within an assemblage, the “sheddase complex,” containing a rhomboid pseudoprotease (iRhom1 or iRhom2). iRhoms control multiple aspects of ADAM17 biology. The FERM domain–containing protein iTAP/Frmd8 is an iRhom-binding protein that prevents the precocious shunting of ADAM17 and iRhom2 to lysosomes and their consequent degradation. As pathophysiological role(s) of iTAP/Frmd8 have not been addressed, we characterized the impact of iTAP/Frmd8 loss on ADAM17-associated phenotypes in mice. We show that iTAP/Frmd8 KO mice exhibit defects in inflammatory and intestinal epithelial barrier repair functions, but not the collateral defects associated with global ADAM17 loss. Furthermore, we show that iTAP/Frmd8 regulates cancer cell growth in a cell-autonomous manner and by modulating the tumor microenvironment. Our work suggests that pharmacological intervention at the level of iTAP/Frmd8 may be beneficial to target ADAM17 activity in specific compartments during chronic inflammatory diseases or cancer, while avoiding the collateral impact on the vital functions associated with the widespread inhibition of ADAM17.
Cholecalciferol (VD3) Attenuates L-DOPA-Induced Dyskinesia in Parkinsonian Mice Via Modulation of Microglia and Oxido-Inflammatory Mechanisms Adedamola Bayo-Olugbami, AbdulRazaq Bidemi Nafiu, Abdulbasit Amin, Olalekan Michael Ogundele, Charles C. Lee, et al. Nigerian Journal of Physiological Sciences, 2022 L-DOPA, the gold standard for managing Parkinson’s disease (PD) is fraught by motor fluctuations termed L-Dopa-Induced Dyskinesia (LID). LID has very few therapeutic options. Hence, the need for preclinical screening of new interventions. Cholecalciferol (VD3) treatment reportedly improves motor deficit in experimental Parkinsonism. Therefore, the novel anti-dyskinetic effect of VD3 and its underlying mechanisms in LID was investigated. Dyskinesia was induced by chronic L-DOPA administration in parkinsonian (6-OHDA- lesioned) mice. The experimental groups: Control, Dyskinesia, Dyskinesia/VD3, and Dyskinesia/Amantadine were challenged with L-DOPA to determine the abnormal involuntary movements (AIMs) score during 14 days of VD3 (30 mg/kg) or Amantadine (40 mg/kg) treatment. Behavioral Axial, Limb & Orolingual (ALO) AIMs were scored for 1 min at every 20 mins interval, over a duration of 100 mins on days 1,3,7,11 and 14. Using western blot, striatum was assessed for expression of dopamine metabolic enzymes: Tyrosine Hydroxylase (TH) and Monoamine Oxidase-B (MAO-B); CD11b, BAX, P47phox, and IL-1β. Cholecalciferol significantly attenuated AIMs only on days 11 & 14 with maximal reduction of 32.7%. Expression of TH and MAO-B was not altered in VD3 compared with dyskinetic mice. VD3 significantly inhibited oxidative stress (P47phox), apoptosis (BAX), inflammation (IL-1β) and microglial activation (CD11b). VD3 showed anti-dyskinetic effects behaviorally by attenuating abnormal involuntary movements, modulation of striatal oxidative stress, microglial responses, inflammation, and apoptotic signaling; without affecting dopamine metabolic enzymes. Its use in the management of dyskinesia is promising. More studies are required to further evaluate these findings. Keywords: Cholecalciferol; L-DOPA-Induced Dyskinesia; Parkinson’s Disease; Microglial; Oxidative stress; Inflammation
Pro-neurogenic and antioxidant efficacy of Nigella sativa oil reduced vulnerability cholinesterase dysfunction and disruption in amygdala-dependent behaviours in chlorpyrifos exposure Journal of Krishna Institute of Medical Sciences University, 2018
Exogenous administration of l-arginine enhances the anti-inflammatory activity of nigella sativa (Blackseed) oil in wistar rats Pharmacologyonline, 2014
ADAM17 and its proteolytic targets in disease pathogenesis A Amin, M Badenes The FEBS Journal , 2026 2026
iTAP/FRMD8 is required for ADAM17-mediated functions in inflammatory diseases M Badenes, E Burbridge, I Oikonomidi, É de Carvalho, A Amin, P Faísca, ... Revista Lusófona de Ciência e Medicina Veterinária 20, 7-7 , 2026 2026
Direct suppression of host gluconeogenesis by Trypanosoma brucei L Figueiredo, A Amin, J Colaço, H Machado, H Nunes-Cabaço, ... 2026
Intranasal Dexamethasone Selectively Impairs Exploratory and Learning Behaviour While Sparing Peripheral Metabolic and Oxidative Homeostasis in Adult Mice A Amin, WI Abdulmajeed, AB Nafiu, O Akinola, AL Oyewole, FF Olagunju, ... Nigerian journal of physiological sciences: official publication of the … , 2025 2025
Zinc Supplementation Reverses Lead-Induced Anxiety-Like Behaviour and Social Deficits in Male Wistar Rats WI Abdulmajeed, AA Suleiman, SA Ismail, FO Ajadi, TM Sanni, ... Nigerian journal of physiological sciences: official publication of the … , 2025 2025
EMBO Workshop Host–Parasite Relationship 2025: cutting-edge science from the shores of Les Embiez NB Marzook, E Silvester, D Sparvoli, P Faral-Tello, G Wendt, ... Trends in Parasitology , 2025 2025
Vitamin E-valproate co-therapy attenuated oxidative stress, neuroinflammation, related cognitive deficits and neuronal damage in Cypermethrin exacerbated seizure A Imam, AM Tunde, A Amin, WI Abdulmajeed, AG Attai, AA Akorede, ... BMC Pharmacology and Toxicology 26 (1), 1-13 , 2025 2025 Citations: 2
How pathogens drive adipose tissue loss in the host A Amin, DV Ferreira, LM Figueiredo Current Opinion in Microbiology 85, 102597 , 2025 2025 Citations: 4
Glucagon in glucose homeostasis and metabolic disease: from physiology to therapeutics A Amin, TM Salman Journal of basic and clinical physiology and pharmacology 36 (2-3), 139-146 , 2025 2025 Citations: 1
A critical role for the ER Membrane Complex (EMC) in lipid droplet homeostasis E de Carvalho, A Amin, R Little, KF Silva, C Gaspar, M Badenes, ... bioRxiv, 2025.03. 10.642408 , 2025 2025
Optimization of Parkinson's disease therapy with plant extracts and nutrition’s evolving roles PO Abolarin, A Amin, AB Nafiu, OM Ogundele, BV Owoyele IBRO Neuroscience Reports 17, 1-12 , 2024 2024 Citations: 17
iRhom2/ADAM17 deletion protects from obesity associated to increased adipocyte thermogenesis and differentiation and reduced adipocyte Semaphorin 4B shedding M Badenes, A Amin, I González-García, J Tüshaus, I Félix, E Burbridge, ... Revista Lusófona de Ciência e Medicina Veterinária 15, 10-10 , 2024 2024
Semaphorin 4B is an ADAM17-cleaved adipokine that inhibits adipocyte differentiation and thermogenesis A Amin, M Badenes, J Tüshaus, É de Carvalho, E Burbridge, P Faísca, ... Molecular metabolism 73, 101731 , 2023 2023 Citations: 11
The ADAM17 sheddase complex regulator iTAP/Frmd8 modulates inflammation and tumor growth M Badenes, E Burbridge, I Oikonomidi, A Amin, É de Carvalho, L Kosack, ... Life Science Alliance 6 (4) , 2023 2023 Citations: 13
Cholecalciferol (VD3) attenuates L-DOPA-induced dyskinesia in parkinsonian mice via modulation of microglia and oxido-inflammatory mechanisms AA Bayo-Olugbami, AB Nafiu, A Amin, OM Ogundele, CC Lee, ... Nigerian journal of physiological sciences: official publication of the … , 2022 2022 Citations: 5
Semaphorin 4B is an ADAM17-cleaved inhibitor of adipocyte thermogenesis A Amin, M Badenes, J Tüshaus, É de Carvalho, E Burbridge, P Faísca, ... bioRxiv, 2022.10. 11.511765 , 2022 2022
Selenium reduces nociceptive response in acute 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP)-induced neurotoxicity PO Abolarin, AB Nafiu, AL Oyewole, A Amin, OM Ogundele, BV Owoyele IBRO neuroscience reports 12, 1-11 , 2022 2022 Citations: 10
The ADAM17 sheddase complex regulator iTAP modulates inflammation, epithelial repair, and tumor growth M Badenes, E Burbridge, I Oikonomidi, A Amin, É de Carvalho, L Kosack, ... BioRxiv, 2022.04. 11.487842 , 2022 2022 Citations: 6
Vitamin D attenuated 6-OHDA-induced behavioural deficits, dopamine dysmetabolism, oxidative stress, and neuro-inflammation in mice A Bayo-Olugbami, AB Nafiu, A Amin, OM Ogundele, CC Lee, BV Owoyele Nutritional neuroscience 25 (4), 823-834 , 2022 2022 Citations: 55
Role of the Metalloprotease Adam17 in Metabolic Regulation A Amin PQDT-Global , 2022 2022
MOST CITED SCHOLAR PUBLICATIONS
Honey prevents neurobehavioural deficit and oxidative stress induced by lead acetate exposure in male wistar rats-a preliminary study WI Abdulmajeed, HB Sulieman, MO Zubayr, A Imam, A Amin, ... Metabolic brain disease 31 (1), 37-44 , 2016 2016 Citations: 85
Hepatoprotective and pancreatoprotective properties of the ethanolic extract of Nigerian propolis IR Babatunde, A Abdulbasit, MI Oladayo, OI Olasile, FR Olamide, ... Journal of intercultural ethnopharmacology 4 (2), 102 , 2015 2015 Citations: 73
Current status of endoplasmic reticulum stress in type II diabetes S Mustapha, M Mohammed, AK Azemi, AI Jatau, A Shehu, L Mustapha, ... Molecules 26 (14), 4362 , 2021 2021 Citations: 66
Vitamin D attenuated 6-OHDA-induced behavioural deficits, dopamine dysmetabolism, oxidative stress, and neuro-inflammation in mice A Bayo-Olugbami, AB Nafiu, A Amin, OM Ogundele, CC Lee, BV Owoyele Nutritional neuroscience 25 (4), 823-834 , 2022 2022 Citations: 55
Two decades of neuroscience publication trends in Africa MB Maina, U Ahmad, HA Ibrahim, SK Hamidu, FE Nasr, AT Salihu, ... Nature communications 12 (1), 3429 , 2021 2021 Citations: 44
Deletion of iRhom2 protects against diet-induced obesity by increasing thermogenesis M Badenes, A Amin, I González-García, I Félix, E Burbridge, M Cavadas, ... Molecular Metabolism 31, 67-84 , 2020 2020 Citations: 33
Black seed oil ameliorated scopolamine-induced memory dysfunction and cortico-hippocampal neural alterations in male Wistar rats A Imam, MS Ajao, MI Ajibola, A Amin, WI Abdulmajeed, AZ Lawal, ... Bulletin of faculty of pharmacy, cairo university 54 (1), 49-57 , 2016 2016 Citations: 30
Cannabis-induced moto-cognitive dysfunction in wistar rats: ameliorative efficacy of nigella sativa A Imam, MS Ajao, A Amin, WI Abdulmajeed, A Ibrahim, OJ Olajide, ... The Malaysian journal of medical sciences: MJMS 23 (5), 17 , 2016 2016 Citations: 27
Oral Ingestion of Cannabis sativa : Risks, Benefits, and Effects on Malaria-Infected Hosts O Akinola, EO Ogbeche, HA Olumoh-Abdul, AO Alli-Oluwafuyi, ... Cannabis & Cannabinoid Research 3 (1), 219-227 , 2018 2018 Citations: 24
Glucocorticoid receptor activation selectively influence performance of Wistar rats in Y-maze A Abdulbasit, FS Michael, AS Onaopemipo, AO Abdulmusawwir, I Aminu, ... Pathophysiology 25 (1), 41-50 , 2018 2018 Citations: 24
Effect of Nigerian propolis on glycemia, lipid profile, and oxidative stress markers in alloxan-induced diabetic rats A Abdulbasit, M Oladayo, F Olamide, O Olasile, I Babatunde, B Gbolahan PHOL 2, 149-158 , 2013 2013 Citations: 20
Pro-Neurogenic and Antioxidant Efficacy of Nigella sativa Oil Reduced Vulnerability Cholinesterase Dysfunction and Disruption in Amygdala-Dependent Behaviours in Chlorpyrifos … A Imam, NA Sulaiman, AL Oyewole, A Amin, STT Shittu, MS Ajao Journal of Krishna Institute of Medical Sciences (JKIMSU) 7 (3) , 2018 2018 Citations: 19
− NMDA R/+ VDR pharmacological phenotype as a novel therapeutic target in relieving motor–cognitive impairments in Parkinsonism OM Ogundele, ET Nanakumo, AO Ishola, OM Obende, LA Enye, ... Drug and chemical toxicology 38 (4), 415-427 , 2015 2015 Citations: 19
Optimization of Parkinson's disease therapy with plant extracts and nutrition’s evolving roles PO Abolarin, A Amin, AB Nafiu, OM Ogundele, BV Owoyele IBRO Neuroscience Reports 17, 1-12 , 2024 2024 Citations: 17
Black seed oil reversed scopolamine-induced Alzheimer and corticohippocampal neural alterations in male Wistar rats A Imam, MS Ajao, MI Ajibola, A Amin, AI Abdulmajeed, AZ Lawal, ... Bull. Fac. Pharm. Cairo Univ 54 (1), 1-106 , 2016 2016 Citations: 16
Anti-androgenic and insulin-sensitizing actions of Nigella sativa oil improve polycystic ovary and associated dyslipidemia and redox disturbances AB Nafiu, S Alimi, A Babalola, AT Ogunlade, FD Muhammad, A Abioye, ... J Complement Med Res 10 (4), 186-199 , 2019 2019 Citations: 15
Neuroscience in Nigeria: the past, the present and the future WG Balogun, AE Cobham, A Amin Metabolic brain disease 33 (2), 359-368 , 2018 2018 Citations: 14
Repeated Acute Oral Exposure to Cannabis sativa Impaired Neurocognitive Behaviours and Cortico-hippocampal Architectonics in Wistar Rats. A Imam, MS Ajao, OB Akinola, MI Ajibola, A Ibrahim, A Amin, ... Nigerian journal of physiological sciences: official publication of the … , 2017 2017 Citations: 14
Black seed oil improves motor and anxiety-like behaviors and cerebellar cyto-architectonic in adult male wistar rats MS Ajao, A Imam, A Amin, WI Abdulmajeed, MI Ajibola, A Alli-Oluwafuyi, ... Niger J Neurosci 8 (1-2), 8-14 , 2016 2016 Citations: 14
Vitamin D3 receptor activation rescued corticostriatal neural activity and improved motor-cognitive function in− D2R Parkinsonian mice model AO Ishola, BJ Laoye, DE Oyeleke, OO Bankole, MU Sirjao, AE Cobham, ... J. Biomedical Science and Engineering, 1-15 , 2015 2015 Citations: 14