OLATUNJI AISHAT OMOBOLANLE

Dr. Aishat Omobolanle OLATUNJI, is a lecturer I staff of University of Ilorin in the Department of Veterinary Pharmacology and Toxicology, Faculty of Veterinary Medicine, with seven years of teaching, research, clinical and administrative experience. She has been serving as a level adviser for almost four years up till date and is the executive secretary to the Faculty Webring Officer. Her areas of research interest include Pesticide and Reproductive toxicity vis a vis Antioxidant Amelioration. She is currently carrying out her PhD research on neuro-behavioral and developmental changes in female rats exposed to pesticides. She has over 15 Publications in highly rated journals and has successfully supervised two undergraduate student projects. Dr. Aishat is a member of the Veterinary Council of Nigeria and Nigerian Veterinary Medical association with up to date licenses.

EDUCATION

DVM, MSc. PhD(in-view): AHMADU BELLO UNIVERSITY, ZARIA

RESEARCH, TEACHING, or OTHER INTERESTS

General Veterinary, Small Animals, Developmental Neuroscience, General Pharmacology, Toxicology and Pharmaceutics

FUTURE PROJECTS

Scopus Publications

Retraction note: Flavonoid fractions of diosmin and hesperidin mitigate lead acetate-induced biochemical, oxidative stress, and histopathological alterations in Wistar rats (Toxicological Research, (2021), 37, 4, (473-484), 10.1007/s43188-020-00084-9)
Ibrahim Yusuf Lamidi, Hudu Garba Mikail, Sani Adamu, Isaac Oluwatobi Akefe, Mohammed Bashir Tijjani, Sabo Isa Salihu, Aisha Omobolanle Olatunji, Abdussalam Hassan, Nubwa Daniel, and Victoria Aderonke Adegoke
Springer Science and Business Media LLC



Ameliorative potentials of diosmin and hesperidin fractions on chlorpyriphos-induced changes in reproductive hormones, sperm characteristics, and testicular glycogen in male Wistar rats
Aishat Omobolanle Olatunji, Joseph Olusegun Ayo, Mohammed Musa Suleiman, Suleiman Folorunsho Ambali, Muftau Shittu, Ganiu Jimoh Akorede, Abdulfatai Aremu, Ibrahim Yusuf Lamidi, Basiru Afisu, and Olubukola Tolulope Adenubi
Springer Science and Business Media LLC



Vitamin C Protects Against Blood and Thyroid Toxicities Induced by the Chronic Use of Carbamazepine in Rats
Ganiu Jimoh Akorede, , Suleiman Folorunsho Ambali, Aisha Omobolanle Olatunji, Abdulfatai Aremu, Akeem Olayiwola Ahmed, Afisu Basiru, Mistura Oyebisi Azeez, Fatima Sanusi, Rafiu Adebisi Kadir,et al.
Negah Scientific Publisher
Background: Drugs are the mainstay of the clinical management of epilepsy. Carbamazepine (CBZ) is commonly used for treating epilepsy and neuropathic pain. This drug has been reported to have toxic effects on the hematological system due to its induction of oxidative stress. This study aimed to investigate the protective effects of vitamin C against hematological and thyroid toxicities caused by the chronic use of carbamazepine in male Wistar rats. Methods: Thirty-two adult Wistar rats were categorized randomly into four groups of eight rats each and treated as follows: Group 1 received distilled water (2 mL/kg); group 2 was treated with vitamin C (100 mg/kg); group 3 received carbamazepine (20 mg/kg), and group 4 was pre-treated with vitamin C (100 mg/kg) and given carbamazepine (20 mg/kg) 30 min later. All treatments were administered via gavage once per day over fifteen consecutive weeks. The rats’ blood samples were tested for changes in hematological parameters while the sera were evaluated for liver biochemical enzymes and thyroid hormone levels. Results: The results revealed that pre-treatment with vitamin C protected against alterations in parameters associated with hematological and thyroid toxicities. Conclusion: Based on the study results, it was concluded that: a) The chronic use of CBZ caused hematological and thyroid toxicities, and b) Vitamin C protected against these toxicities. Therefore, it is highly likely that vitamin C has the potential to protect experimental animals against injuries induced by CBZ to the liver, blood cells, and hypothalamic-pituitary-thyroid axis in a Wistar rat model.


Effect of daflon-500^®, a flavonoid compound on chlorpyriphos-induced oxidative changes in the hypophysis and testes in adult male rats
Aishat O. Olatunji, Joseph O. Ayo, Mohammed M. Suleiman, Suleiman F. Ambali, Muftau Shittu, Ganiu J. Akorede, Lukman O. Raji, Jamila A. Atata, Khalid T. Biobaku, and Mistura O. Azeez
Springer Science and Business Media LLC



Mitigative potentials of methanol leaf extract of Moringa oleifera on chronic carbamazepine-induced haemo-biochemical and thyrotoxicity in male Wistar rats
Ganiu Jimoh Akorede, Suleiman Folorunsho Ambali, Aisha Omobolanle Olatunji, Abdulfatai Aremu, Afisu Basiru, Akeem Olayiwola Ahmed, Mistura Olabisi Azeez, Isiaku Abdulmajeed, and Rafiu Adebisi Kadir
Elsevier BV



Flavonoid fractions of diosmin and hesperidin mitigate lead acetate-induced biochemical, oxidative stress, and histopathological alterations in Wistar rats
Ibrahim Yusuf Lamidi, Hudu Garba Mikail, Sani Adamu, Isaac Oluwatobi Akefe, Mohammed Bashir Tijjani, Sabo Isa Salihu, Aisha Omobolanle Olatunji, Abdussalam Hassan, Nubwa Daniel, and Victoria Aderonke Adegoke
Springer Science and Business Media LLC



Melatonin mitigates thyroid dysfunction induced by gestational and lactational exposure to mixture of chlorpyriphos and cypermethrin in male Wistar rats
Muftau Shittu, Suleiman Folorunsho Ambali, Joseph Olusegun Ayo, Mohammed Umaru Kawu, and Aishat Omobolanle Olatunji
Springer Science and Business Media LLC



Anti-anaemic effect of ethanol leaf extract of Cnidosculus aconitifolius on cyclophosphomide-induced anaemia in rats
Jamila Abdulhamid Atata, Taiwo Oluwaseun Ayoola, Abdullateef Abiodun Ajadi, Sani Adamu, Aishat O. Olatunji, and Khalid Talha Biobaku
Walter de Gruyter GmbH
Abstract Background The folkloric claim that Cnidoscolus aconitifolius (Chaya) could ameliorate anaemia requires scientific revalidation in anaemic models. Objective The aim of this study is to investigate the anti-anaemic effect of Cnidoscolus aconitifolius on cyclophosphamide-induced anaemia in rats. Methods The leaves of Cnidoscolus aconitifolius were collected, dried and extracted with ethanol. Twenty five Wistar Albino rats weighing 120–180 kg were used. Anaemia was induced in groups 2, 3, 4 and 5 with a single injection of cyclophosphamide, while group 1 served as a negative control without anemia and was treated with 0.5 mL of normal saline, Group 2 rats were treated with 100 mg/kg body weight of Cnidoscolus aconitifolius. Group 3 rats were treated with 500 mg/kg body weight of Cnidoscolus aconitifolius. Group 4 served as the positive control rats and was treated with 0.5 mL of normal saline. Group 5 which served as the standard control rats and were treated with 5 mg/kg body weight of standard drug Chemiron. The treated lasted for two weeks during which blood samples were collected from each rat for haematological analysis. Results The result shows that hematological parameters were elevated in groups 2, 3 and 5 rats treated with 100 mg/kg and 500 mg/kg body weight of ethanol extract of Cnidoscolus aconitifolius and chemiron respectively. Conclusions Ethanol leaf extract of Cnidoscolus aconitifolius at a graded dose of 500 mg/kg body weight had higher ameliorative effect on the haematological parameters of cyclophosphamide-induced anemia in rats.

RECENT SCHOLAR PUBLICATIONS