Dr. Aishat Omobolanle OLATUNJI, is a lecturer I staff of University of Ilorin in the Department of Veterinary Pharmacology and Toxicology, Faculty of Veterinary Medicine, with seven years of teaching, research, clinical and administrative experience. She has been served in many administrative capacities. Her areas of research interest include Pesticide, Neurobehavioral and Reproductive toxicity vis a vis Antioxidant Amelioration. She has over 20 Publications in highly rated journals and has successfully supervised several undergraduate student projects. Dr. Aishat is a member of the Veterinary Council of Nigeria and Nigerian Veterinary Medical association with up to date licenses.
EDUCATION
DVM, MSc. PhD(Veterinary Toxicology) AHMADU BELLO UNIVERSITY, ZARIA
RESEARCH, TEACHING, or OTHER INTERESTS
General Veterinary, Small Animals, Developmental Neuroscience, General Pharmacology, Toxicology and Pharmaceutics
FUTURE PROJECTS
Neurobehavioral studies in rats
Applications Invited
Developmental changes in pregnant female rats exposed to pesticides.
Applications Invited
Hormonal/Reproductive changes in rats exposed to pesticides
Cimetidine-induced Male Reproductive Defects in Piroxicam-induced Gastric Ulcerated Wistar Rats and Their Amelioration by Melatonin Afisu Basiru, Oluwatobi Adetunji, Ganiu Akorede, Abdulfatai Aremu, Abdullahi Ishola, et al. Iranian Journal of Veterinary Science and Technology, 2025 Cimetidine is a known reproductive toxicant due to its adverse effects on testicular function. Melatonin is an antioxidant that has a role in mitigating any disorders that could affect spermatogenesis. Therefore, this study evaluated the ameliorative potential of melatonin on the adverse reproductive effects of cimetidine in piroxicam-induced gastric ulcerated male rats. Thirty rats were randomly divided into six groups (n=5), including normal control (distilled water), ulcerated and non-treated, ulcerated and treated with cimetidine (200mg/kg day), ulcerated and treated with cimetidine and melatonin (10mg/kg), treated with cimetidine and melatonin without ulceration, and ulcerated rats treated with only melatonin. All treatments were done orally per day for 14 days. On the 15th day, rats were sacrificed, and blood samples were collected for hormone and antioxidant assays. Then, the sperm parameters were analyzed according to standard procedures. Co-administration of melatonin to piroxicam-ulcerated rats treated with cimetidine showed a significant increase (p < 0.05) in sperm count and epididymal glutathione peroxidase compared to piroxicam-ulcerated rats treated with only cimetidine. Melatonin increases the serum level of Testosterone, FSH, and LH. Melatonin ameliorates the adverse reproductive effects of cimetidine through its antioxidant properties. Therefore, co-administration of melatonin with cimetidine in male ulcer patients is recommended.
Co-administration of Hibiscus sabdariffa linn and Daflon-500® mitigates weight loss, hyperglycemia, hematological and oxidative changes in male rats with type-2 diabetes Aishat Omobolanle Olatunji, Root Oluwapelumi Alegbe, Suleiman Folorunsho Ambali, Muftau Shittu, Ganiu Jimoh Akorede, Abdulfatai Aremu, Afisu Basiru, Jamila Abdulhamid Atata, Kolawole Yusuf Suleiman, Charles Amoto Shuaibu Phytomedicine Plus, 2025 • The synergistic/comparative effects of Hibiscus sabdariffa Linn and Daflon-500® versus the conventional type-2 diabetes agent, metformin were evaluated in this study. • Co-Administration of Hibiscus sabdariffa Linn and Daflon-500® potentiated the effect of metformin by improving body weight and blood glucose from day 21-28. • Hibiscus sabdariffa Linn and Daflon-500® possess potent antioxidant and hemato-protective effects in type-2 diabetes patients. • The use of plant phenolics should be incorporated as an adjunct to treatment in type-2 diabetes patients. Diabetes mellitus is a complex metabolic disorder associated with persistent hyperglycemia and metabolic imbalance. Flavonoid compounds possess notable qualities in mitigating diabetes and its complications. Hibiscus sabdariffa linn and daflon-500® were assessed for their effects on body weight, blood glucose/indices, and oxidative changes in type-2 diabetes rats over 28 days. 35 male rats were randomly divided into seven groups (n=5). Diabetes mellitus was induced in groups 2-7 via a single intraperitoneal injection of streptozotocin (STZ; 55mg/kg). Group 1(DW) received distilled water (2mL/kg) only. Group 2 (STZ; untreated), group 3 {MET; metformin (200mg/kg)}, group 4 {HS; Hibiscus sabdariffa (400mg/kg)}, group 5 {DAF; daflon-500® (1000mg/kg)}, group 6 {DAF+HS; daflon-500® (1000mg/kg) and Hibiscus sabdariffa (400mg/kg)}, group 7 {DAF+MET+HS; daflon-500® (1000mg/kg), metformin (200mg/kg), and Hibiscus sabdariffa (400mg/kg)}. Body weight and blood glucose were assessed fortnightly. Blood and hepatic/pancreatic tissues were collected for hematological and antioxidant testing. Groups 2-7 revealed a significant (P<0.05) decrease in body weight on day 14 compared to the increased growth rate observed on day 28 (Group 7). Blood glucose levels significantly increased on days 1 and 14 in groups 2-7 but declined on day 28 in groups 4-7. Significantly higher packed cell volume, hemoglobin levels, red blood cell counts, lymphocytes, and mean corpuscular hemoglobin were observed in groups 5-7. Platelet counts were higher in Groups 2 and 5. Untreated group 2 exhibited considerably reduced catalase activity, glutathione, and malondialdehyde concentrations compared to the treated groups. Hibiscus sabdariffa linn and Daflon-500® expressed substantial hypoglycemic, antioxidant, and hemato-protective effects.
Vitamin C Protects Against Blood and Thyroid Toxicities Induced by the Chronic Use of Carbamazepine in Rats Ganiu Jimoh Akorede, , Suleiman Folorunsho Ambali, Aisha Omobolanle Olatunji, Abdulfatai Aremu, Akeem Olayiwola Ahmed, Afisu Basiru, Mistura Oyebisi Azeez, Fatima Sanusi, Rafiu Adebisi Kadir, Isiaku Abdulmajeed, , , , , , , , , and Iranian Journal of Toxicology, 2023 Background: Drugs are the mainstay of the clinical management of epilepsy. Carbamazepine (CBZ) is commonly used for treating epilepsy and neuropathic pain. This drug has been reported to have toxic effects on the hematological system due to its induction of oxidative stress. This study aimed to investigate the protective effects of vitamin C against hematological and thyroid toxicities caused by the chronic use of carbamazepine in male Wistar rats. Methods: Thirty-two adult Wistar rats were categorized randomly into four groups of eight rats each and treated as follows: Group 1 received distilled water (2 mL/kg); group 2 was treated with vitamin C (100 mg/kg); group 3 received carbamazepine (20 mg/kg), and group 4 was pre-treated with vitamin C (100 mg/kg) and given carbamazepine (20 mg/kg) 30 min later. All treatments were administered via gavage once per day over fifteen consecutive weeks. The rats’ blood samples were tested for changes in hematological parameters while the sera were evaluated for liver biochemical enzymes and thyroid hormone levels. Results: The results revealed that pre-treatment with vitamin C protected against alterations in parameters associated with hematological and thyroid toxicities. Conclusion: Based on the study results, it was concluded that: a) The chronic use of CBZ caused hematological and thyroid toxicities, and b) Vitamin C protected against these toxicities. Therefore, it is highly likely that vitamin C has the potential to protect experimental animals against injuries induced by CBZ to the liver, blood cells, and hypothalamic-pituitary-thyroid axis in a Wistar rat model.
Mitigative potentials of methanol leaf extract of Moringa oleifera on chronic carbamazepine-induced haemo-biochemical and thyrotoxicity in male Wistar rats Ganiu Jimoh Akorede, Suleiman Folorunsho Ambali, Aisha Omobolanle Olatunji, Abdulfatai Aremu, Afisu Basiru, Akeem Olayiwola Ahmed, Mistura Olabisi Azeez, Isiaku Abdulmajeed, Rafiu Adebisi Kadir Pharmacological Research Modern Chinese Medicine, 2022 Carbamazepine (CBZ) is commonly used for treating epilepsy and neuropathic pain. This present research was carried out to evaluate ameliorative potentials of methanol leaves extract of Moringa oleifera on chronic CBZ-induced haemotoxicity and thyrotoxicosis in male Wistar rats. 32 adult male Wistar rats were divided into four groups of 8 animals each and exposed to the following regimens: Group I (DW) was administered distilled water (2 ml/kg); group II (MO) was exposed M. oleifera (200 mg/kg); group III (CBZ) was given carbamazepine at 20 mg/kg, while group IV (CBZ+MO) was exposed to carbamazepine (20 mg/kg) then followed by M. oleifera (200 mg/kg) 30 minutes later. The regimens were given once daily for 15 weeks via gavage. Blood and serum samples were evaluated for haematological parameters, liver biochemical enzymes and thyroid hormone. The results revealed that M. oleifera leaves extract mitigate against alteration in parameters measuring haematological, biochemical and thyroid functions. The study concluded that amelioration against CBZ-evoked alteration in haematological indices, biochemical enzymes and thyroid function by M. oleifera leave extract was partly due to its nutritional values and phytochemical constituents that confer protection on blood vascular system, and hypothalamic-pituitary axis.
