VIJAY TRIPATHI
@shuats.edu.in
Assistant Professor
SAM HIGGINBOTTOM UNIVERSITY OF AGRICULTURE TECHNOLOGY AND SCIENCES
RESEARCH, TEACHING, or OTHER INTERESTS
Agricultural and Biological Sciences, Molecular Biology, Water Science and Technology, Microbiology
Scopus Publications
Scopus Publications
Anugya Jaiswal, Aquib Khan, Akanksha Yogi, Sweta Singh, Arun Kumar Pal, Ramendra Soni, Pooja Tripathi, Jonathan A. Lal, and Vijay Tripathi
Springer Science and Business Media LLC
Shubham Yadav, Pallavi Kumari, Aditi Sinha, Vijay Tripathi, and Vaibhav Saran
Springer Science and Business Media LLC
Shubham Yadav, Vijay Tripathi, and Vaibhav Saran
Elsevier BV
Uttpal Anand, Tarun Pal, Niraj Yadav, Vipin Kumar Singh, Vijay Tripathi, Krishna Kumar Choudhary, Awadhesh Kumar Shukla, Kumari Sunita, Ajay Kumar, Elza Bontempi,et al.
Springer Science and Business Media LLC
AbstractGlobally, substantial research into endophytic microbes is being conducted to increase agricultural and environmental sustainability. Endophytic microbes such as bacteria, actinomycetes, and fungi inhabit ubiquitously within the tissues of all plant species without causing any harm or disease. Endophytes form symbiotic relationships with diverse plant species and can regulate numerous host functions, including resistance to abiotic and biotic stresses, growth and development, and stimulating immune systems. Moreover, plant endophytes play a dominant role in nutrient cycling, biodegradation, and bioremediation, and are widely used in many industries. Endophytes have a stronger predisposition for enhancing mineral and metal solubility by cells through the secretion of organic acids with low molecular weight and metal-specific ligands (such as siderophores) that alter soil pH and boost binding activity. Finally, endophytes synthesize various bioactive compounds with high competence that are promising candidates for new drugs, antibiotics, and medicines. Bioprospecting of endophytic novel secondary metabolites has given momentum to sustainable agriculture for combating environmental stresses. Biotechnological interventions with the aid of endophytes played a pivotal role in crop improvement to mitigate biotic and abiotic stress conditions like drought, salinity, xenobiotic compounds, and heavy metals. Identification of putative genes from endophytes conferring resistance and tolerance to crop diseases, apart from those involved in the accumulation and degradation of contaminants, could open new avenues in agricultural research and development. Furthermore, a detailed molecular and biochemical understanding of endophyte entry and colonization strategy in the host would better help in manipulating crop productivity under changing climatic conditions. Therefore, the present review highlights current research trends based on the SCOPUS database, potential biotechnological interventions of endophytic microorganisms in combating environmental stresses influencing crop productivity, future opportunities of endophytes in improving plant stress tolerance, and their contribution to sustainable remediation of hazardous environmental contaminants. Graphical Abstract
Nirdesh Kumar Ravi, Pawan Kumar Jha, Kriti Varma, Piyush Tripathi, Sandeep Kumar Gautam, Kirpa Ram, Manish Kumar, and Vijay Tripathi
Elsevier BV
Sweta Nidhi, Pooja Tripathi, and Vijay Tripathi
Springer Science and Business Media LLC
Saumya Tewari, Munish Kumar Mishra, Vijay Tripathi, and Vaibhav Saran
Diva Enterprises Private Limited
Abhijeet W. Singh, Ramendra Soni, Arun Kumar Pal, Pooja Tripathi, Jonathan A. Lal, and Vijay Tripathi
Elsevier
Tarun Pal, Uttpal Anand, Shreya Sikdar Mitra, Protha Biswas, Vijay Tripathi, Jarosław Proćków, Abhijit Dey, and José M. Pérez de la Lastra
Informa UK Limited
Since the end of February 2020, the world has come to a standstill due to the virus SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2). Since then, the global scientific community has explored various remedies and treatments against this virus, including natural products that have always been a choice because of their many benefits. Various known phytochemicals are well documented for their antiviral properties. Research is being carried out to discover new natural plant products or existing ones as a treatment measure for this disease. The three important targets in this regard are-papain like protease (PLpro), spike protein, and 3 chymotrypsin like proteases (3CLpro). Various docking studies are also being elucidated to identify the phytochemicals that modulate crucial proteins of the virus. The paper is simultaneously a comprehensive review that covers recent advances in the domain of the effect of various botanically derived natural products as an alternative treatment approach against Coronavirus Disease 2019 (COVID-19). Furthermore, the docking analyses revealed that rutin (inhibitor of the major protease of SARS-CoV-2), gallocatechin (e.g., interacting with 03 hydrogen bonds with a spike-like protein), lycorine (showing the best binding affinity with amino acids GLN498, THR500 and GLY446 of the spike-like protein), and quercetrin (inhabiting at its residues ASP216, PHE219, and ILE259) are promising inhibitors of SARS‑CoV‑2.Communicated by Ramaswamy H. Sarma.
Deeksha Tiwari, Gaurava Srivastava, Omkar Indari, Vijay Tripathi, Mohammad Imran Siddiqi, and Hem Chandra Jha
Informa UK Limited
Recent reports suggest that persistent Epstein-Barr virus (EBV) infection and its recurrent reactivation could instigate the formation of proteinaceous plaques in the brain: a hallmark of Alzheimer's disease (AD). Interestingly, a major genetic risk factor of AD, the apolipoprotein E (ApoE), could also influence the outcome of EBV infection in an individual. The ApoE is believed to influence the proteinaceous plaque clearance from the brain, and its defective functioning could result in the aggregate deposition. The persistent presence of EBV infection in a genetically predisposed individual could create a perfect recipe for severe neurodegenerative consequences. Therefore, in the present study, we investigated the possible interactions between ApoE and various EBV proteins using computational tools. Our results showed possibly stable de-novo interactions between the C-terminal domain of ApoE3 and EBV proteins: EBV nuclear antigen-1 (EBNA1) and BamHI Z fragment leftward open reading frame-1 (BZLF1). The EBNA1 protein of EBV plays a crucial role in establishing latency and replication of the virus. Whereas BZLF1 is involved in the lytic replication cycle. The proposed interaction of EBV proteins at the ligand-binding site of ApoE3 on CTD could interfere with- its capability to sequester amyloid fragments and, hence their clearance from the brain giving rise to AD pathology. This study provides a new outlook on EBV's underexplored role in AD development and paves the way for novel avenues of investigation which could further our understanding of AD pathogenesis.Communicated by Ramaswamy H. Sarma[Figure: see text].
Nirdesh Kumar Ravi, Arun Kumar Pal, Ramendra Soni, Pooja Tripathi, Anjali Singhal, Pawan Kumar Jha, and Vijay Tripathi
IWA Publishing
Abstract Excessive anthropogenic activities play a significant role in the emergence and dissemination of antibiotic resistance in urban streams and river sediment. The objectives of the present study were to investigate the antibiotic susceptibility profile, molecular detection of antibiotic resistance genes (ARGs), and identification of multidrug-resistant bacterial isolates in the mainstream and tributaries of the Ghaghara River. The obtained data indicated that the majority of the isolates were identified as Bacillus spp. (40%) followed by Klebsiella quasipneumoniae (20%), Exiguobacterium undae (13.33%). Most of the bacterial isolates were resistant against penicillin G (P) (24%), cefuroxime (CXM) (20%), amoxicillin (AMX) (18%), and ampicillin (AMP) (17%) in sediments samples, whereas penicillin G (27%), cefuroxime (CXM) and erythromycin (E) was 13%, AMP and cefaclor both showed 12% in water samples respectively. This study provides insight into the prevalence of multiple antibiotic-resistant bacterial diversity in the Ghaghara River and provides the route to disseminate the multidrug-resistant pathogens in the human and animal population through the aquatic environment.
Denis Horgan, Rizwana Mia, Tosan Erhabor, Yosr Hamdi, Collet Dandara, Jonathan A. Lal, Joel Fokom Domgue, Oladimeji Ewumi, Teresia Nyawira, Salomé Meyer,et al.
MDPI AG
Tackling cancer is a major challenge right on the global level. Europe is only the tip of an iceberg of cancer around the world. Prosperous developed countries share the same problems besetting Europe–and the countries and regions with fewer resources and less propitious conditions are in many cases struggling often heroically against a growing tide of disease. This paper offers a view on these geographically wider, but essentially similar, challenges, and on the prospects for and barriers to better results in this ceaseless battle. A series of panels have been organized by the European Alliance for Personalised Medicine (EAPM) to identify different aspects of cancer care around the globe. There is significant diversity in key issues such as NGS, RWE, molecular diagnostics, and reimbursement in different regions. In all, it leads to disparities in access and diagnostics, patients’ engagement, and efforts for a better understanding of cancer.
Ramendra Soni, Arun Kumar Pal, Pooja Tripathi, Pawan Kumar Jha, and Vijay Tripathi
IWA Publishing
Abstract The inadequate practice of discharge of wastewater into receiving water bodies alters physicochemical parameters, which ultimately disturbs the livelihood of aquatic flora and fauna. The present study was focussed on the evaluation of the efficiencies of wastewater treatment plants based on different technologies through analysing the physicochemical parameters of wastewater collected from each treatment step including inlet, outlet and downstream Ganges River in Prayagraj, Varanasi and Kanpur (India) during winter and summer seasons. The removal efficiency of the MBBR technology of Prayagraj WWTP was observed to be better than that of the ASP and UASB technologies of Varanasi and Kanpur respectively for both seasons. Correlation analysis explained the strong negative correlation of pH and DO with nearly all the parameters of the study; whereas TDS, hardness, ammonia and BOD were highly correlated with each other in each city. The factor analysis suggested the best fit amongst the physicochemical parameters, with four factors elucidating 78.00% of the total variance, which further explained that DO, TDS, total alkalinity, nitrate, COD, and temperature were the major components for pollution. The results indicated that most of the samples were not appropriate for direct discharge into water bodies and irrigation purposes and thus needed further implementation of advanced technologies in their treatment procedure.
Uttpal Anand, Champa Keeya Tudu, Samapika Nandy, Kumari Sunita, Vijay Tripathi, Gary J. Loake, Abhijit Dey, and Jarosław Proćków
Elsevier BV
Raches Ella, Siddarth Reddy, William Blackwelder, Varsha Potdar, Pragya Yadav, Vamshi Sarangi, Vinay K Aileni, Suman Kanungo, Sanjay Rai, Prabhakar Reddy,et al.
Elsevier BV
Pradeep Kumar, Dipendra Kumar Mahato, Madhu Kamle, Rituraj Borah, Bharti Sharma, Shikha Pandhi, Vijay Tripathi, Hardeo Singh Yadav, Sheetal Devi, Umesh Patil,et al.
Wiley
Marijuana, or Cannabis sativa L., is a common psychoactive plant used for both recreational and medicinal purposes. In many countries, cannabis-based medicines have been legalized under certain conditions because of their immense prospects in medicinal applications. With a comprehensive insight into the prospects and challenges associated with the pharmacological use and global trade of C. sativa, this mini-review focuses on the medicinal importance of the plant and its legal status worldwide; the pharmacological compounds and its therapeutic potential along with the underlying public health concerns and future perspective are herein discussed. The existence of major compounds including Δ9 -tetrahydrocannabinol (Δ9 -THC), cannabidiol, cannabinol, and cannabichromene contributes to the medicinal effects of the cannabis plant. These compounds are also involved in the treatment of various types of cancer, epilepsy, and Parkinson's disease displaying several mechanisms of action. Cannabis sativa is a plant with significant pharmacological potential. However, several aspects of the plant need an in-depth understanding of the drug mechanism and its interaction with other drugs. Only after addressing these health concerns, legalization of cannabis could be utilized to its full potential as a future medicine.
Samarpita Banerjee, Uttpal Anand, Suchhanda Ghosh, Durga Ray, Puja Ray, Samapika Nandy, Ganpat Dewaji Deshmukh, Vijay Tripathi, and Abhijit Dey
Wiley
From ancient history, complementary and alternative medicines have played a significant role as holistic therapeutic treatments of various human diseases including cancer, diabetes, neurological diseases, and skin problems. One Indian medicinal plant (herb), Bacopa monnieri has been used in many parts of the world as such medicine, particularly for the treatment of various neurological disorders. It is well known as a potent “tonic for the human brain,” which serves as a memory enhancer. Multiple studies proved that this herb contains a plethora of potential bioactive, phytochemical compounds with synergistic properties. The main purpose of the present review is to shed light on the use of Bacopa monnieri and its active principles (bacosides) in the management of neurological disorders. Furthermore, the signaling pathways modulated by bacosides have been critically discussed in this review. Moreover, we have critically summarized the present knowledge of this perennial creeping herb based upon the literature mining from different scientific engines.
Uttpal Anand, Francesco Bianco, S. Suresh, Vijay Tripathi, Avelino Núñez-Delgado, and Marco Race
Elsevier BV
Bahare Salehi, Cristina Quispe, Monica Butnariu, Ioan Sarac, Ilias Marmouzi, Madhu Kamle, Vijay Tripathi, Pradeep Kumar, Abdelhakim Bouyahya, Esra Capanoglu,et al.
Wiley
Plants of the genus Brassica occupy the top place among vegetables in the world. This genus, which contains a group of six related species of a global economic significance, three of which are diploid: Brassica nigra (L.) K. Koch, Brassica oleracea L., and Brassica rapa L. and three are amphidiploid species: Brassica carinata A. Braun, Brassica juncea (L.) Czern., and Brassica napus L. These varieties are divided into oily, fodder, spice, and vegetable based on their morphological structure, chemical composition, and usefulness of plant organs. The present review provides information about habitat, phytochemical composition, and the bioactive potential of Brassica plants, mainly antioxidant, antimicrobial, anticancer activities, and clinical studies in human. Brassica vegetables are of great economic importance around the world. At present, Brassica plants are grown together with cereals and form the basis of global food supplies. They are distinguished by high nutritional properties from other vegetable plants, such as low fat and protein content and high value of vitamins, fibers along with minerals. In addition, they possess several phenolic compounds and have a unique type of compounds namely glucosinolates that differentiate these crops from other vegetables. These compounds are also responsible for numerous biological activities to the genus Brassica as described in this review.
Uttpal Anand, Shweta Jakhmola, Omkar Indari, Hem Chandra Jha, Zhe-Sheng Chen, Vijay Tripathi, and José M. Pérez de la Lastra
Frontiers Media SA
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is a highly pathogenic novel virus that has caused a massive pandemic called coronavirus disease 2019 (COVID-19) worldwide. Wuhan, a city in China became the epicenter of the outbreak of COVID-19 in December 2019. The disease was declared a pandemic globally by the World Health Organization (WHO) on 11 March 2020. SARS-CoV-2 is a beta CoV of the Coronaviridae family which usually causes respiratory symptoms that resemble common cold. Multiple countries have experienced multiple waves of the disease and scientific experts are consistently working to find answers to several unresolved questions, with the aim to find the most suitable ways to contain the virus. Furthermore, potential therapeutic strategies and vaccine development for COVID-19 management are also considered. Currently, substantial efforts have been made to develop successful and safe treatments and SARS-CoV-2 vaccines. Some vaccines, such as inactivated vaccines, nucleic acid-based, and vector-based vaccines, have entered phase 3 clinical trials. Additionally, diverse small molecule drugs, peptides and antibodies are being developed to treat COVID-19. We present here an overview of the virus interaction with the host and environment and anti-CoV therapeutic strategies; including vaccines and other methodologies, designed for prophylaxis and treatment of SARS-CoV-2 infection with the hope that this integrative analysis could help develop novel therapeutic approaches against COVID-19.
Uttpal Anand, Carlo Cabreros, Joyabrata Mal, Florencio Ballesteros, Mika Sillanpää, Vijay Tripathi, and Elza Bontempi
Elsevier BV
Kavindra Kumar Kesari, Ramendra Soni, Qazi Mohammad Sajid Jamal, Pooja Tripathi, Jonathan A. Lal, Niraj Kumar Jha, Mohammed Haris Siddiqui, Pradeep Kumar, Vijay Tripathi, and Janne Ruokolainen
Springer Science and Business Media LLC
AbstractWater scarcity is one of the major problems in the world and millions of people have no access to freshwater. Untreated wastewater is widely used for agriculture in many countries. This is one of the world-leading serious environmental and public health concerns. Instead of using untreated wastewater, treated wastewater has been found more applicable and ecofriendly option. Moreover, environmental toxicity due to solid waste exposures is also one of the leading health concerns. Therefore, intending to combat the problems associated with the use of untreated wastewater, we propose in this review a multidisciplinary approach to handle wastewater as a potential resource for use in agriculture. We propose a model showing the efficient methods for wastewater treatment and the utilization of solid wastes in fertilizers. The study also points out the associated health concern for farmers, who are working in wastewater-irrigated fields along with the harmful effects of untreated wastewater. The consumption of crop irrigated by wastewater has leading health implications also discussed in this review paper. This review further reveals that our current understanding of the wastewater treatment and use in agriculture with addressing advancements in treatment methods has great future possibilities.
Uttpal Anand, Bashir Adelodun, Alberto Pivato, S. Suresh, Omkar Indari, Shweta Jakhmola, Hem Chandra Jha, Pawan Kumar Jha, Vijay Tripathi, and Francesco Di Maria
Elsevier BV
Uttpal Anand, Bhaskar Reddy, Vipin Kumar Singh, Amit Kishore Singh, Kavindra Kumar Kesari, Pooja Tripathi, Pradeep Kumar, Vijay Tripathi, and Jesus Simal-Gandara
MDPI AG
The disposal of municipal solid waste (MSW) directly at landfills or open dump areas, without segregation and treatment, is a significant concern due to its hazardous contents of antibiotic-resistant bacteria (ARB), antibiotic resistance genes (ARGs), and metal resistance genes (MGEs). The released leachate from landfills greatly effects the soil physicochemical, biological, and groundwater properties associated with agricultural activity and human health. The abundance of ARB, ARGs, and MGEs have been reported worldwide, including MSW landfill sites, animal husbandry, wastewater, groundwater, soil, and aerosol. This review elucidates the occurrence and abundance of ARB, ARGs, and MRGs, which are regarded as emerging contaminants (ECs). Recently, ECs have received global attention because of their prevalence in leachate as a substantial threat to environmental and public health, including an economic burden for developing nations. The present review exclusively discusses the demands to develop a novel eco-friendly management strategy to combat these global issues. This review also gives an intrinsic discussion about the insights of different aspects of environmental and public health concerns caused due to massive leachate generation, the abundance of antibiotics resistance (AR), and the effects of released leachate on the various environmental reservoirs and human health. Furthermore, the current review throws light on the source and fate of different ECs of landfill leachate and their possible impact on the nearby environments (groundwater, surface water, and soil) affecting human health. The present review strongly suggests the demand for future research focuses on the advancement of the removal efficiency of contaminants with the improvement of relevant landfill management to reduce the potential effects of disposable waste. We propose the necessity of the identification and monitoring of potential environmental and human health risks associated with landfill leachate contaminants.